Simian immunodeficiency virus
Simian Acquired Immunodeficiency Syndrome
Macaca mulatta
HIV-1
SAIDS Vaccines
Virus Replication
Macaca nemestrina
HIV-2
Gene Products, gag
Macaca
Gene Products, env
HIV Infections
HIV
Molecular Sequence Data
Gene Products, nef
Cercocebus atys
Acquired Immunodeficiency Syndrome
Genes, nef
Viral Load
Immunodeficiency Virus, Feline
Cercopithecus
Genes, env
CD4-Positive T-Lymphocytes
Antigens, CD4
Amino Acid Sequence
HIV Envelope Protein gp120
nef Gene Products, Human Immunodeficiency Virus
Receptors, CCR5
AIDS Vaccines
Neutralization Tests
Mandrillus
Viral Regulatory and Accessory Proteins
tat Gene Products, Human Immunodeficiency Virus
Retroviridae Proteins
Macaca fascicularis
Base Sequence
Genes, gag
Cercocebus
CD8-Positive T-Lymphocytes
CD4 Lymphocyte Count
Anti-HIV Agents
Leukocytes, Mononuclear
Viral Envelope Proteins
Proviruses
Monkey Diseases
Virion
Feline Acquired Immunodeficiency Syndrome
HIV Antigens
Vaccinia virus
gag Gene Products, Human Immunodeficiency Virus
Vaccines, Attenuated
Lentivirus Infections
HIV Reverse Transcriptase
Reverse Transcriptase Inhibitors
Gene Products, tat
Receptors, Virus
Cercopithecus aethiops
HIV Core Protein p24
Gene Products, vpr
Zidovudine
Receptors, HIV
Lentiviruses, Primate
RNA-Directed DNA Polymerase
Encephalitis, Viral
HIV Long Terminal Repeat
Gene Products, pol
Colobus
HIV Envelope Protein gp41
Gene Products, vif
Human Immunodeficiency Virus Proteins
vpr Gene Products, Human Immunodeficiency Virus
Genetic Vectors
Virus Assembly
Polymerase Chain Reaction
Genes, pol
T-Lymphocytes
Genes, vpr
T-Lymphocytes, Cytotoxic
Gene Products, rev
Receptors, CXCR4
Antiviral Agents
Cells, Cultured
HIV Seropositivity
Vaccines, Synthetic
Lymph Nodes
Organophosphonates
DNA Primers
HeLa Cells
Pan troglodytes
Gene Expression Regulation, Viral
vif Gene Products, Human Immunodeficiency Virus
rev Gene Products, Human Immunodeficiency Virus
Viral Vaccines
env Gene Products, Human Immunodeficiency Virus
Genes, rev
Mutation
HIV Envelope Protein gp160
Vaccination
HIV Protease Inhibitors
Retroviruses, Simian
Vaccines, DNA
Genes, vpu
Genes, tat
Virus Integration
Giant Cells
Lymphoid Tissue
Primate Diseases
Macrophages
Fusion Proteins, gag-pol
Lymphocyte Activation
HIV Protease
Sequence Analysis, DNA
CD4-CD8 Ratio
Virulence
Disease Models, Animal
Drug Resistance, Viral
Administration, Rectal
Haplorhini
Mucous Membrane
Epitopes, T-Lymphocyte
AIDS Dementia Complex
Genes, vif
Species Specificity
Immunization, Secondary
Antiretroviral Therapy, Highly Active
AIDS-Related Opportunistic Infections
Cytopathogenic Effect, Viral
Immunity, Mucosal
Reassortant Viruses
Severe Combined Immunodeficiency
Histocompatibility Antigens Class I
Cell Fusion
Transfection
Sequence Homology, Amino Acid
Recombination, Genetic
Retroviridae Proteins, Oncogenic
Superinfection
Immunodeficiency Virus, Bovine
HIV Seronegativity
Virus Shedding
Antibodies, Neutralizing
Sequence Alignment
Immunodominant Epitopes
Immunization
Disease Progression
Flow Cytometry
Cyclophilin A
Infectious Disease Transmission, Vertical
Cercopithecidae
Cats
Amino Acid Substitution
Mutagenesis, Site-Directed
Enzyme-Linked Immunosorbent Assay
Lentivirus
Lymphocytes
Cross Reactions
Cloning, Molecular
Virus Latency
Viral Fusion Proteins
Defective Viruses
Disease Transmission, Infectious
Retroviridae
T-Lymphocyte Subsets
Membrane Fusion
Cercopithecinae
Erythrocebus patas
Lymphocyte Depletion
Binding Sites
Cameroon
Jurkat Cells
Evolution, Molecular
Administration, Intravaginal
Interferon-gamma
Cytidine Deaminase
RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques. (1/2811)
Primary infection of macaques with pathogenic isolates of simian immunodeficiency virus (SIV) (as a model of HIV infection in humans) represents a unique opportunity to study early lentivirus/host interactions. We sought to determine whether there is a temporal relationship linking SIV replication and dissemination and the expression of the chemokine RANTES (regulated upon activation normal T cell expressed and secreted) and the SIV/HIV coreceptor CCR5 in different tissues during acute SIV infection of macaques. Four cynomolgus macaques were inoculated intravenously with a pathogenic primary isolate of SIVmac251. RT-PCR was used to monitor the expression of RANTES and CCR5 mRNA in fresh isolated mononuclear cells from blood, lymph node, and bronchoalveolar lavages. These expressions were compared to those of IFN-gamma as an indicator of the development of the immune response and to another receptor for RANTES, CCR1, which is not described as a coreceptor for SIV/HIV-1 entry. An enhancement of CCR1/CCR5 mRNA expression was noticed during primary SIVmac251 infection of macaques, mainly in tissue. In the three different compartments investigated, IFN-gamma and RANTES overexpression was noticed by the time of systemic viral replication containment. Our results put CCR5 and RANTES mRNA expression back in the context of inflammatory and immune responses to SIV primary infection. (+info)Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function. (2/2811)
The simian immunodeficiency virus macC8 (SIVmacC8) variant has been used in a European Community Concerted Action project to study the efficacy and safety of live attenuated SIV vaccines in a large number of macaques. The attenuating deletion in the SIVmacC8 nef-long terminal repeat region encompasses only 12 bp and is "repaired" in a subset of infected animals. It is unknown whether C8-Nef retains some activity. Since it seems important to use only well-characterized deletion mutants in live attenuated vaccine studies, we analyzed the relevance of the deletion, and the duplications and point mutations selected in infected macaques for Nef function in vitro. The deletion, affecting amino acids 143 to 146 (DMYL), resulted in a dramatic decrease in Nef stability and function. The initial 12-bp duplication resulted in efficient Nef expression and an intermediate phenotype in infectivity assays, but it did not significantly restore the ability of Nef to stimulate viral replication and to downmodulate CD4 and class I major histocompatibility complex cell surface expression. The additional substitutions however, which subsequently evolved in vivo, gradually restored these Nef functions. It was noteworthy that coinfection experiments in the T-lymphoid 221 cell line revealed that even SIVmac nef variants carrying the original 12-bp deletion readily outgrew an otherwise isogenic virus containing a 182-bp deletion in the nef gene. Thus, although C8-Nef is unstable and severely impaired in in vitro assays, it maintains some residual activity to stimulate viral replication. (+info)Lentivirus vectors using human and simian immunodeficiency virus elements. (3/2811)
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells. Although high-titer HIV-1-derived vectors have been produced, concerns regarding safety still exist. Safety concerns arise mainly from the possibility of recombination between transfer and packaging vectors, which may give rise to replication-competent viruses with pathogenic potential. We describe a novel lentivirus vector which is based on HIV, simian immunodeficiency virus (SIV), and vesicular stomatitis virus (VSV) and which we refer to as HIV/SIVpack/G. In this system, an HIV-1-derived genome is encapsidated by SIVmac core particles. These core particles are pseudotyped with VSV glycoprotein G. Because the nucleotide homology between HIV-1 and SIVmac is low, the likelihood of recombination between vector elements should be reduced. In addition, the packaging construct (SIVpack) for this lentivirus system was derived from SIVmac1A11, a nonvirulent SIV strain. Thus, the potential for pathogenicity with this vector system is minimal. The transduction ability of HIV/SIVpack/G was demonstrated with immortalized human lymphocytes, human primary macrophages, human bone marrow-derived CD34(+) cells, and primary mouse neurons. To our knowledge, these experiments constitute the first demonstration that the HIV-1-derived genome can be packaged by an SIVmac capsid. We demonstrate that the lentivirus vector described here recapitulates the biological properties of HIV-1-derived vectors, although with increased potential for safety in humans. (+info)Early short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine treatment favorably alters the subsequent disease course in simian immunodeficiency virus-infected newborn Rhesus macaques. (4/2811)
Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study disease pathogenesis and to develop intervention strategies aimed at delaying disease. In the present study, we demonstrate that very early events of infection greatly determine the ultimate disease course, as short-term antiviral drug administration during the initial viremia stage significantly delayed the onset of AIDS. Fourteen newborn macaques were inoculated orally with uncloned, highly virulent SIVmac251. The four untreated control animals showed persistently high virus levels and poor antiviral immune responses; they developed fatal immunodeficiency within 15 weeks. In contrast, SIV-infected newborn macaques which were started on 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) treatment at 5 days of age and continued for either 14 or 60 days showed reduced virus levels and enhanced antiviral immune responses. This short-term PMPA treatment did not induce detectable emergence of SIV mutants with reduced in vitro susceptibility to PMPA. Although viremia increased in most animals after PMPA treatment was withdrawn, all animals remained disease-free for at least 6 months. Our data suggest that short-term treatment with a potent antiviral drug regimen during the initial viremia will significantly prolong AIDS-free survival for HIV-infected infants and adults. (+info)Protection of macaques against intrarectal infection by a combination immunization regimen with recombinant simian immunodeficiency virus SIVmne gp160 vaccines. (5/2811)
We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous virus E11S but that this protection was only partially effective against the uncloned virus, SIVmne. In the present study, we examine the protective efficacy of this immunization regimen against infection by a mucosal route. We found that the same gp160-based vaccines were highly effective against intrarectal infection not only with the E11S clone but also with the uncloned SIVmne. Protection against mucosal infection is therefore achievable by parenteral immunization with recombinant envelope vaccines. Protection appears to correlate with high levels of SIV-specific antibodies and, in animals protected against the uncloned virus, the presence of serum-neutralizing activities. To understand the basis for the differential efficacies against the uncloned virus by the intravenous versus the intrarectal routes, we examined viral sequences recovered from the peripheral blood mononuclear cells of animals early after infection by both routes. We previously showed that the majority (85%) of the uncloned SIVmne challenge stock contained V1 sequences homologous to the molecular clone from which the vaccines were made (E11S type), with the remainder (15%) containing multiple conserved changes (the variant types). In contrast to intravenously infected animals, from which either E11S-type or the variant type V1 sequences could be recovered in significant proportions, animals infected intrarectally had predominantly E11S-type sequences. Preferential transmission or amplification of the E11S-type viruses may therefore account in part for the enhanced efficacy of the recombinant gp160 vaccines against the uncloned virus challenge by the intrarectal route compared with the intravenous route. (+info)Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. (6/2811)
To determine the role of CD8(+) T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of CD8 cells in peripheral blood in six infected Macaca mulatta treated with OKT8F. The apparent CD8 depletion started 1 h after antibody administration, and low CD8 levels were maintained until day 8. An increase in plasma viremia of one to three orders of magnitude was observed in five of the six macaques. The injection of a control antibody to an infected macaque did not induce a sustained viral load increase, nor did it significantly reduce the number of CD8(+) T cells. These results demonstrate that CD8 cells play a crucial role in suppressing SIV replication in vivo. (+info)Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses. (7/2811)
To determine the role of viral burden in simian-human immunodeficiency virus (SHIV)-induced disease, cellular provirus and plasma viral RNA levels were measured after inoculation of rhesus monkeys with four different SHIVs. These SHIVs included SHIV-HXBc2 and SHIV-89.6, constructed with env, tat, rev, and vpu derived from either cell line-passaged or primary patient isolates of human immunodeficiency virus type 1; the viral quasispecies SHIV-89.6P derived after in vivo passage of SHIV-89.6; and a molecular clone, SHIV-KB9, derived from SHIV-89.6P. SHIV-HXBc2 and SHIV-89.6 are nonpathogenic in rhesus monkeys; SHIV-89.6P and SHIV-KB9 cause rapid CD4(+) T cell depletion and an immunodeficiency syndrome. Relative SHIV provirus levels were highest during primary infection in monkeys infected with SHIV-89.6P, the virus that caused the most rapid and dramatic CD4(+) T cell depletion. However, by 10 weeks postinoculation, provirus levels were similar in monkeys infected with the pathogenic and nonpathogenic chimeric viruses. The virus infections that resulted in the highest peak and chronic viral RNA levels were the pathogenic viruses SHIV-89.6P and SHIV-KB9. SHIV-89. 6P uniformly caused rapid and profound CD4(+) T cell depletion and immunodeficiency. Infection with the SHIV-KB9 resulted in very low CD4(+) T cell counts without seroconversion in some monkeys and a substantial but less profound CD4(+) T cell depletion and rapid seroconversion in others. Surprisingly, the level of plasma viremia did not differ between SHIV-KB9-infected animals exhibiting these contrasting outcomes, suggesting that host factors may play an important role in AIDS virus pathogenesis. (+info)Secretion of beta-chemokines by bronchoalveolar lavage cells during primary infection of macaques inoculated with attenuated nef-deleted or pathogenic simian immunodeficiency virus strain mac251. (8/2811)
Primary infection of macaques with simian immunodeficiency virus (SIV) as a model of human immunodeficiency virus (HIV) infection represents a unique opportunity to investigate early lentivirus-host interactions. In order to gain insight into immunopathogenic events taking place in the lung during lentiviral infection, we analysed lymphocyte expansion in the lung and chemokine secretion by mononuclear cells obtained by bronchoalveolar lavage (BALMCs) during primary infection by a pathogenic and a non-pathogenic SIV. Two groups of cynomolgus macaques were inoculated intravenously with a fully pathogenic isolate of SIVmac251 or with an attenuated, nef-deleted, molecular clone of SIVmac251. Spontaneous MIP-1alpha, MIP-1beta and RANTES production was assessed by ELISA in supernatants of short-term cultured BALMCs. Kinetics of haematological, virological and immunological parameters were investigated simultaneously. All 11 inoculated animals became infected. Monkeys inoculated with the nef-deleted SIV clone exhibited a significantly reduced plasma virus load and a less pronounced accumulation of lymphocytes in the lung compared to monkeys infected with the pathogenic SIVmac251 isolate. Compared to pre-infection levels, we observed an increase in the levels of RANTES, MIP1-alpha and MIP1-beta production in the two groups of monkeys, by the time of peak viraemia. Strikingly, a greater enhancement of RANTES and MIP-1alpha production was detected in monkeys infected with the attenuated virus. Given the potential influence of beta-chemokines on the immune response and virus replication, such results suggest that RANTES, MIP1-alpha and MIP1-beta could contribute to the singular features of the immune response elicited during infection of macaques with an attenuated SIV. (+info)Simian Acquired Immunodeficiency Syndrome (SAIDS) is a disease that affects primates, including monkeys and chimpanzees, and is caused by a virus similar to the human immunodeficiency virus (HIV). SAIDS is characterized by a weakened immune system, which makes the affected animals more susceptible to infections and diseases. The symptoms of SAIDS are similar to those of HIV in humans, including fever, weight loss, and swollen lymph nodes. SAIDS is transmitted through contact with bodily fluids, such as blood, semen, and vaginal fluids, and can be spread through sexual contact, sharing needles, or from mother to child during pregnancy or breastfeeding. SAIDS is a serious and often fatal disease, and there is currently no cure for it.
SAIDS Vaccines refer to vaccines that are designed to prevent or treat HIV/AIDS, the virus that causes Acquired Immune Deficiency Syndrome (AIDS). HIV is a highly infectious virus that attacks the immune system, leading to a weakened immune response and making individuals more susceptible to other infections and diseases. There are currently no vaccines that can completely prevent HIV infection, but there are several vaccines that are being developed and tested in clinical trials. These vaccines aim to stimulate the immune system to produce antibodies that can neutralize the virus and prevent it from infecting cells. Some of the most promising HIV vaccine candidates are based on a protein called gp120, which is found on the surface of the virus. These vaccines are designed to stimulate the production of antibodies that can recognize and bind to gp120, preventing the virus from entering cells. Other HIV vaccine candidates are based on viral vectors, which are modified viruses that are used to deliver genetic material into cells. These vaccines aim to stimulate the immune system to produce a broad range of antibodies that can recognize and attack different strains of the virus. While there is still much work to be done in the development of effective HIV vaccines, these vaccines hold great promise for preventing and treating this devastating disease.
In the medical field, "Gene Products, gag" refers to the proteins that are produced by the gag gene in retroviruses such as HIV. The gag gene encodes for several structural proteins that are essential for the replication and assembly of the virus. These proteins include the capsid protein (CA), the nucleocapsid protein (NC), and the matrix protein (MA). The capsid protein is responsible for forming the viral capsid, which encloses the viral RNA genome. The nucleocapsid protein helps package the viral RNA into the capsid and also plays a role in viral transcription and replication. The matrix protein is involved in the assembly of new virus particles and also helps the virus to bud from the host cell. The gag gene products are important for the replication and survival of the virus, and they are also targets for antiretroviral drugs used to treat HIV infection.
"Gene Products, env" is not a commonly used term in the medical field. It is possible that it may refer to a specific gene product or protein that is associated with the environment, but without more context, it is difficult to provide a more specific definition. It is important to note that gene products are the end products of genes, which are segments of DNA that code for specific proteins or RNA molecules. These gene products play important roles in various biological processes and can be influenced by environmental factors.
HIV (Human Immunodeficiency Virus) infections refer to the presence of the HIV virus in the body. HIV is a retrovirus that attacks and weakens the immune system, making individuals more susceptible to infections and diseases. HIV is transmitted through contact with infected bodily fluids, such as blood, semen, vaginal fluids, and breast milk. The most common modes of transmission include unprotected sexual contact, sharing needles or syringes, and from mother to child during pregnancy, childbirth, or breastfeeding. HIV infections can be diagnosed through blood tests that detect the presence of the virus or antibodies produced in response to the virus. Once diagnosed, HIV can be managed with antiretroviral therapy (ART), which helps to suppress the virus and prevent the progression of the disease to AIDS (Acquired Immune Deficiency Syndrome). It is important to note that HIV is not the same as AIDS. HIV is the virus that causes AIDS, but not everyone with HIV will develop AIDS. With proper treatment and management, individuals with HIV can live long and healthy lives.
In the medical field, "Gene Products, nef" refers to a protein encoded by the HIV-1 nef gene. The nef gene is a regulatory gene that is expressed in infected cells and plays a role in the pathogenesis of HIV-1 infection. The nef protein has several functions, including downregulation of CD4 and MHC class I molecules on the surface of infected cells, inhibition of apoptosis (programmed cell death), and modulation of immune responses. These functions contribute to the ability of HIV-1 to evade the immune system and persist in infected individuals. The nef protein has been implicated in the development of AIDS and is a target for the development of antiretroviral therapies.
Acquired Immunodeficiency Syndrome (AIDS) is a life-threatening condition caused by the human immunodeficiency virus (HIV). HIV is a virus that attacks the immune system, specifically the CD4 cells, which are responsible for fighting off infections and diseases. As the number of CD4 cells decreases, the body becomes more vulnerable to infections and diseases that it would normally be able to fight off. AIDS is typically diagnosed when a person's CD4 cell count falls below a certain level or when they develop certain opportunistic infections or cancers that are commonly associated with HIV. There is currently no cure for AIDS, but antiretroviral therapy (ART) can help to suppress the virus and prevent the progression of the disease. With proper treatment, people with AIDS can live long and healthy lives.
RNA, Viral refers to the genetic material of viruses that are composed of RNA instead of DNA. Viral RNA is typically single-stranded and can be either positive-sense or negative-sense. Positive-sense RNA viruses can be directly translated into proteins by the host cell's ribosomes, while negative-sense RNA viruses require a complementary positive-sense RNA intermediate before protein synthesis can occur. Viral RNA is often encapsidated within a viral capsid and can be further protected by an envelope made of lipids and proteins derived from the host cell. RNA viruses include a wide range of pathogens that can cause diseases in humans and other organisms, such as influenza, hepatitis C, and SARS-CoV-2 (the virus responsible for COVID-19).
Viremia is a medical term that refers to the presence of viruses in the bloodstream. It is a normal part of the viral replication cycle, during which the virus multiplies inside host cells and then enters the bloodstream. In some cases, viremia can be asymptomatic, meaning that the person infected with the virus does not experience any symptoms. However, in other cases, viremia can cause a range of symptoms, depending on the type of virus and the severity of the infection. Viremia is typically measured by detecting the viral particles or genetic material of the virus in a blood sample using laboratory tests. The level of viremia can be used to monitor the progression of the infection and to determine the effectiveness of antiviral treatments.
CD4 antigens, also known as CD4 molecules, are a type of protein found on the surface of certain cells in the immune system. These cells, called T cells, play a crucial role in the body's defense against infection and disease. CD4 antigens are specifically associated with helper T cells, which are a type of T cell that works to coordinate the immune response by activating other immune cells. Helper T cells express high levels of CD4 antigens on their surface, which allows them to bind to and activate other immune cells, such as B cells and macrophages. In the context of the human immunodeficiency virus (HIV), the virus specifically targets and destroys CD4+ T cells, leading to a weakened immune system and an increased susceptibility to opportunistic infections and certain types of cancer. Therefore, CD4+ T cell count is often used as a key indicator of HIV infection and disease progression.
HIV Envelope Protein gp120 is a glycoprotein that is found on the surface of the human immunodeficiency virus (HIV). It plays a critical role in the virus's ability to infect and infect cells. gp120 binds to specific receptors on the surface of immune cells, allowing the virus to enter and infect the cell. This protein is also a major target for the immune system, and antibodies against gp120 can help to prevent HIV infection. In addition, gp120 is a major component of the virus's structure, and it is involved in the formation of the viral envelope.
Antibodies, viral, are proteins produced by the immune system in response to a viral infection. They are also known as immunoglobulins or antibodies. Viral antibodies are specific to a particular virus and can help to neutralize and eliminate the virus from the body. They are typically detected in the blood or other bodily fluids using laboratory tests, such as enzyme-linked immunosorbent assays (ELISAs) or immunofluorescence assays. The presence of viral antibodies can be used as a diagnostic tool to confirm a viral infection or to determine the immune status of an individual.
The "nef Gene Products, Human Immunodeficiency Virus" refers to the proteins encoded by the nef gene of the human immunodeficiency virus (HIV). The nef gene is a regulatory gene that is expressed during the late stages of HIV replication and is thought to play a role in the pathogenesis of HIV infection. The nef gene products are multifunctional proteins that have been shown to modulate various cellular processes, including cell signaling, trafficking, and apoptosis. They have been implicated in the ability of HIV to evade the immune system, as well as in the development of certain HIV-related complications, such as cardiovascular disease and neurocognitive disorders. The nef gene products are not essential for the survival of HIV in vitro, but they have been shown to enhance viral replication and pathogenesis in vivo. As a result, they are considered to be important targets for the development of new antiretroviral therapies for the treatment of HIV infection.
Receptors, CCR5, are a type of cell surface receptor protein that are expressed on the surface of certain immune cells, such as T cells and macrophages. These receptors are part of the chemokine receptor family and are activated by certain chemokines, which are signaling molecules that help to regulate the movement and function of immune cells. The CCR5 receptor plays an important role in the immune response to HIV (human immunodeficiency virus), which targets and destroys CD4+ T cells, a type of immune cell that expresses CCR5 on its surface. HIV uses the CCR5 receptor to enter and infect these cells. As a result, individuals who lack functional CCR5 receptors (due to a genetic mutation) are resistant to HIV infection. In addition to its role in HIV infection, the CCR5 receptor has been implicated in a variety of other immune-related disorders, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. As such, the CCR5 receptor is an important target for the development of new therapies for these conditions.
In the medical field, "DNA, Viral" refers to the genetic material of viruses, which is composed of deoxyribonucleic acid (DNA). Viruses are infectious agents that can only replicate inside living cells of organisms, including humans. The genetic material of viruses is different from that of cells, as viruses do not have a cellular structure and cannot carry out metabolic processes on their own. Instead, they rely on the host cell's machinery to replicate and produce new viral particles. Understanding the genetic material of viruses is important for developing treatments and vaccines against viral infections. By studying the DNA or RNA (ribonucleic acid) of viruses, researchers can identify potential targets for antiviral drugs and design vaccines that stimulate the immune system to recognize and fight off viral infections.
HIV (Human Immunodeficiency Virus) antibodies are proteins produced by the immune system in response to the presence of the HIV virus. These antibodies are specific to the HIV virus and can be detected in the blood or other bodily fluids of an individual who has been infected with the virus. The presence of HIV antibodies in the blood is a diagnostic indicator of HIV infection. However, it is important to note that the presence of HIV antibodies does not necessarily mean that an individual is currently infected with the virus. It is possible for an individual to test positive for HIV antibodies if they have previously been infected with the virus, even if they are no longer infected. HIV antibodies can also be used to monitor the progression of HIV infection and the effectiveness of antiretroviral therapy (ART). As an individual with HIV receives ART, their HIV viral load (the amount of virus present in the blood) should decrease, and their CD4 T-cell count (a type of white blood cell that is important for fighting infections) should increase. These changes can be monitored through regular blood tests that measure HIV viral load and CD4 T-cell count, as well as through the detection of HIV antibodies.
AIDS vaccines are vaccines designed to prevent the acquisition of the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). These vaccines aim to stimulate the immune system to recognize and attack HIV, thereby preventing infection or reducing the severity of the disease if infection occurs. There are several types of AIDS vaccines being developed, including preventive vaccines that aim to prevent initial infection and therapeutic vaccines that aim to treat already infected individuals. Preventive vaccines typically use antigens from HIV to stimulate an immune response, while therapeutic vaccines aim to boost the immune system's ability to fight off the virus. Despite significant progress in the development of AIDS vaccines, no vaccine has yet been approved for widespread use. However, several vaccines are currently in clinical trials, and researchers continue to work on developing effective vaccines to prevent and treat HIV/AIDS.
Viral regulatory and accessory proteins are non-structural proteins that are produced by viruses during the course of their replication cycle. These proteins play a variety of roles in the virus life cycle, including regulating viral gene expression, modulating the host immune response, and facilitating viral assembly and release. Some examples of viral regulatory and accessory proteins include the viral protease, which is responsible for cleaving viral polyproteins into individual functional proteins, and the viral RNA-dependent RNA polymerase, which is responsible for replicating the viral genome. Other examples include proteins that help the virus evade the host immune system, such as viral interferon antagonists, or proteins that facilitate viral entry into host cells, such as viral attachment proteins. Viral regulatory and accessory proteins are important targets for antiviral drugs, as they are often essential for the virus to replicate and cause disease. By targeting these proteins, antiviral drugs can help to inhibit viral replication and reduce the severity of viral infections.
The tat gene products of the human immunodeficiency virus (HIV) are a group of proteins that play a critical role in the replication and spread of the virus. The tat gene is one of several regulatory genes found in the HIV genome, and its products are essential for the production of new virus particles. The tat protein is a small, basic protein that is produced by the tat gene and is incorporated into the HIV virion during the assembly process. Once inside a host cell, the tat protein binds to the host cell's transcription machinery and promotes the production of viral RNA, which is then used to produce new virus particles. In addition to its role in viral replication, the tat protein has been shown to have a number of other effects on the host cell, including the induction of cell proliferation, the inhibition of apoptosis (cell death), and the modulation of immune responses. As a result, the tat protein is thought to play a key role in the pathogenesis of HIV infection and the development of AIDS.
Retroviridae proteins are a group of proteins that are encoded by retroviruses, which are a type of virus that can integrate their genetic material into the host cell's genome. These proteins play important roles in the life cycle of retroviruses, including the replication of the viral genome, the assembly of new virus particles, and the infection of new host cells. Some of the key retroviral proteins include: * Reverse transcriptase: This enzyme is responsible for converting the viral RNA genome into DNA, which can then be integrated into the host cell's genome. * Integrase: This enzyme is responsible for integrating the viral DNA into the host cell's genome. * Protease: This enzyme is responsible for processing the viral polyproteins into their individual components, which are then used to assemble new virus particles. * Gag protein: This protein is involved in the assembly of new virus particles. * Env protein: This protein is involved in the attachment of the virus to the host cell and the fusion of the viral envelope with the host cell membrane. Retroviridae proteins are important targets for the development of antiretroviral drugs, which are used to treat HIV and other retroviral infections.
Viral envelope proteins are proteins that are found on the surface of enveloped viruses. These proteins play a crucial role in the viral life cycle, as they are involved in the attachment of the virus to host cells, entry into the host cell, and release of new virus particles from the host cell. There are several different types of viral envelope proteins, including glycoproteins, which are proteins that have attached carbohydrates, and matrix proteins, which help to stabilize the viral envelope. These proteins can be important targets for antiviral drugs, as they are often essential for the virus to infect host cells. In addition to their role in viral infection, viral envelope proteins can also play a role in the pathogenesis of viral diseases. For example, some viral envelope proteins can trigger an immune response in the host, leading to inflammation and tissue damage. Other viral envelope proteins can help the virus evade the host immune system, allowing the virus to persist and cause disease. Overall, viral envelope proteins are important components of enveloped viruses and play a critical role in the viral life cycle and pathogenesis of viral diseases.
Monkey diseases, also known as primate diseases, are infections or illnesses that are caused by viruses, bacteria, or parasites that are naturally found in non-human primates, such as monkeys, apes, and lemurs. These diseases can be transmitted to humans through direct contact with infected animals or their bodily fluids, or through the consumption of contaminated food or water. Some examples of monkey diseases that can be transmitted to humans include: 1. Ebola virus disease: This is a severe and often fatal illness that is caused by the Ebola virus, which is found in primates in Africa. 2. Marburg virus disease: This is another severe and often fatal illness that is caused by the Marburg virus, which is also found in primates in Africa. 3. Monkeypox: This is a viral infection that is caused by the monkeypox virus, which is found in primates in Africa and the Americas. 4. Lassa fever: This is a viral infection that is caused by the Lassa virus, which is found in rats and other small animals in West Africa. 5. Rabies: This is a viral infection that is caused by the rabies virus, which is found in a wide range of animals, including primates. 6. Cholera: This is a bacterial infection that is caused by the Vibrio cholerae bacterium, which is found in contaminated water and food. 7. Typhoid fever: This is a bacterial infection that is caused by the Salmonella typhi bacterium, which is found in contaminated food and water. It is important for healthcare workers and travelers to be aware of the risks of monkey diseases and to take appropriate precautions to prevent infection. This may include avoiding direct contact with wild animals, practicing good hygiene, and receiving appropriate vaccinations.
Feline Acquired Immunodeficiency Syndrome (FIV) is a viral infection that affects cats. It is caused by the Feline Immunodeficiency Virus (FIV), which weakens the immune system of infected cats, making them more susceptible to other infections and diseases. FIV is transmitted through bites and scratches from infected cats, and it is most commonly found in wild and stray cats. The symptoms of FIV can vary, but they may include weight loss, fever, weakness, and anemia. FIV is not contagious to humans, and there is no cure for the virus. However, there are treatments available to help manage the symptoms and improve the quality of life for infected cats.
The gag gene products of human immunodeficiency virus (HIV) are a group of proteins that are encoded by the gag gene in the HIV genome. These proteins play important roles in the replication and survival of the virus. The gag gene products include the capsid protein (CA), the matrix protein (MA), the nucleocapsid protein (NC), and the protease (PR). The capsid protein forms the viral capsid, which protects the viral RNA genome and is essential for viral assembly. The matrix protein is involved in the budding of new virus particles from infected cells. The nucleocapsid protein helps package the viral RNA genome into the capsid. The protease is responsible for cleaving the viral polyproteins into their individual components, which are necessary for viral replication. HIV gag gene products are important targets for antiretroviral therapy, as they are essential for the survival and replication of the virus. Inhibitors of the protease can block the cleavage of the viral polyproteins, preventing the formation of functional virus particles.
In the medical field, "Vaccines, Attenuated" refers to vaccines that are made by weakening or attenuating a pathogen, such as a virus or bacteria, so that it can no longer cause disease in a healthy individual. This weakened pathogen is then introduced into the body to stimulate an immune response, which helps the body to recognize and fight off the pathogen if it is encountered again in the future. Attenuated vaccines are often used to prevent infectious diseases such as measles, mumps, rubella, polio, and yellow fever. They are typically made by growing the pathogen in a laboratory and then exposing it to conditions that weaken it, such as low temperatures or the absence of certain nutrients. The weakened pathogen is then injected into the body, where it triggers an immune response without causing the disease. Attenuated vaccines are generally considered to be safe and effective, and they are one of the most common types of vaccines used in the world. However, like all vaccines, they can cause side effects, such as fever, soreness at the injection site, and rare allergic reactions.
Lentivirus infections refer to a group of viral infections caused by lentiviruses, which are a type of retrovirus. Lentiviruses are characterized by their slow replication rate and ability to infect cells of the immune system, including CD4+ T cells, macrophages, and dendritic cells. Lentiviruses are responsible for several serious diseases, including HIV (human immunodeficiency virus), which causes acquired immunodeficiency syndrome (AIDS). Other lentiviruses include equine infectious anemia virus (EIAV) in horses, feline immunodeficiency virus (FIV) in cats, and simian immunodeficiency virus (SIV) in non-human primates. Lentivirus infections can be transmitted through various means, including sexual contact, blood transfusions, and mother-to-child transmission during pregnancy or breastfeeding. The symptoms of lentivirus infections can vary depending on the specific virus and the stage of the infection. In some cases, there may be no symptoms at all, while in others, symptoms can range from mild to severe and can include fever, fatigue, weight loss, and opportunistic infections. Treatment for lentivirus infections typically involves antiretroviral therapy (ART), which involves taking a combination of medications to suppress the virus and prevent the progression of the disease. In some cases, supportive care may also be necessary to manage symptoms and prevent complications.
HIV Reverse Transcriptase is an enzyme that is produced by the human immunodeficiency virus (HIV). It plays a critical role in the replication of the virus within infected cells. The enzyme converts the viral RNA genome into a complementary DNA (cDNA) molecule, which can then be integrated into the host cell's genome. This process is known as reverse transcription and is a key step in the viral life cycle. HIV Reverse Transcriptase inhibitors are a class of antiretroviral drugs that target this enzyme and are used in the treatment of HIV infection.
In the medical field, "Gene Products, tat" refers to the protein encoded by the HIV-1 tat gene. The tat gene is a regulatory gene that is essential for the replication and transcription of the HIV-1 virus. The tat protein acts as a transcriptional activator, binding to specific DNA sequences and promoting the synthesis of viral RNA. Tat is also involved in the regulation of viral gene expression and the production of viral proteins. In addition to its role in HIV-1 replication, tat has been implicated in a number of other cellular processes, including the regulation of gene expression, cell proliferation, and apoptosis.
Receptors, Virus are proteins on the surface of host cells that recognize and bind to specific viral proteins, allowing the virus to enter and infect the cell. These receptors play a crucial role in the viral life cycle and are often targeted by antiviral drugs and vaccines. Examples of viral receptors include the ACE2 receptor for SARS-CoV-2 (the virus that causes COVID-19) and the CD4 receptor for HIV.
HIV Core Protein p24 is a protein that is produced by the human immunodeficiency virus (HIV) during the early stages of infection. It is a component of the viral core, which is the innermost part of the virus that contains the genetic material. The p24 protein is an important marker for the presence of HIV in the blood and is often used in diagnostic tests to detect the virus. It is also used as an indicator of the level of virus replication and the effectiveness of antiretroviral therapy.
Gene Products, vpr is a protein that is produced by the human immunodeficiency virus (HIV). The vpr gene is one of several accessory genes found in the HIV genome, and it encodes a protein of the same name. The vpr protein plays a role in the pathogenesis of HIV infection by promoting the death of infected immune cells, particularly CD4+ T cells, which are crucial for the body's immune response. It also has the ability to disrupt the normal functioning of the cell cycle, leading to the accumulation of abnormal cells and potentially contributing to the development of certain cancers in people with HIV. In addition to its role in HIV infection, the vpr protein has been studied for its potential as a therapeutic target in the treatment of other diseases, such as multiple sclerosis and cancer.
Zidovudine, also known by its brand name AZT, is an antiretroviral medication used to treat HIV/AIDS. It works by inhibiting the activity of the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. Zidovudine is typically used in combination with other antiretroviral medications to help suppress the virus and prevent the progression of HIV/AIDS. It is usually taken orally in tablet form, and the dosage and duration of treatment will depend on the individual patient's condition and response to the medication. Zidovudine can cause side effects such as nausea, vomiting, headache, and fatigue. It may also interact with other medications, so it is important to inform your healthcare provider of all medications you are taking before starting treatment with zidovudine.
Receptors, HIV refers to the proteins on the surface of certain cells in the human immune system that are targeted by the human immunodeficiency virus (HIV). These receptors, known as CD4 receptors and chemokine receptors, play a crucial role in the entry and replication of HIV in the body. Once HIV binds to these receptors, it is able to enter the cell and use its genetic material to produce more copies of itself, leading to the destruction of immune cells and the progression of HIV infection to acquired immunodeficiency syndrome (AIDS).
RNA-directed DNA polymerase (RDDP) is an enzyme that synthesizes DNA using RNA as a template. It is also known as reverse transcriptase. This enzyme is primarily associated with retroviruses, which are viruses that have RNA genomes that are reverse transcribed into DNA before being integrated into the host cell's genome. In the medical field, RDDP is important because it plays a key role in the replication of retroviruses, such as HIV. HIV uses RDDP to convert its RNA genome into DNA, which is then integrated into the host cell's genome. This integration can lead to the development of AIDS, a life-threatening condition. RDDP is also used in medical research and diagnostics. For example, it is used in the development of antiretroviral drugs, which are used to treat HIV infection. It is also used in the detection of retroviral infections, such as HIV, by detecting the presence of RDDP activity in patient samples.
Encephalitis, viral refers to an inflammation of the brain caused by a viral infection. The virus can affect any part of the brain, but it most commonly affects the temporal lobe, which is responsible for memory and speech. Symptoms of viral encephalitis can include fever, headache, nausea, vomiting, confusion, seizures, and changes in behavior or personality. In severe cases, it can lead to coma or even death. Treatment typically involves antiviral medications, supportive care, and rehabilitation to help manage symptoms and improve outcomes.
"Gene Products, pol" refers to a group of proteins that are produced by the polymerase (pol) genes. These proteins are involved in various cellular processes, including DNA replication, repair, and transcription. In the medical field, the term "Gene Products, pol" may be used in the context of genetic disorders or diseases that are caused by mutations in the pol genes, such as certain types of cancer or inherited disorders that affect the immune system. Additionally, the term may be used in the context of gene therapy, where the goal is to replace or repair defective pol genes in order to treat or prevent these diseases.
HIV Envelope Protein gp41 is a protein that is found on the surface of the human immunodeficiency virus (HIV). It plays a critical role in the virus's ability to infect and infect cells of the immune system. The gp41 protein is responsible for fusion of the HIV viral envelope with the cell membrane, allowing the virus to enter and infect the cell. This process is essential for the virus's replication and spread within the body. Understanding the structure and function of the gp41 protein is important for the development of effective HIV treatments and vaccines.
Vif (Virus infectivity factor) is a protein encoded by the HIV-1 virus that is essential for the replication and survival of the virus. It is a small, unstable protein that is expressed late in the viral life cycle and is not present in the mature virion. Vif plays a critical role in the viral life cycle by counteracting the host's innate immune response, specifically the APOBEC3G (A3G) and APOBEC3F (A3F) proteins, which are cellular enzymes that can induce mutations in the viral genome and inhibit viral replication. Vif binds to A3G and A3F and targets them for degradation by the proteasome, preventing them from inhibiting viral replication. In addition to its role in counteracting the host's innate immune response, Vif also plays a role in the assembly and maturation of the HIV-1 particle. It interacts with the viral Gag protein and is necessary for the proper packaging of the viral RNA genome into the immature virion. Overall, Vif is a critical protein for the replication and survival of the HIV-1 virus and is an important target for the development of antiretroviral therapies.
Human Immunodeficiency Virus (HIV) proteins are the proteins that are produced by the HIV virus. These proteins play a crucial role in the replication and survival of the virus within the host's immune system. There are several types of HIV proteins, including: 1. Gag proteins: These proteins are involved in the assembly and maturation of new virus particles. 2. Pol proteins: These proteins are involved in the replication of the HIV genome. 3. Env proteins: These proteins are responsible for the attachment of the virus to host cells and the fusion of the viral envelope with the host cell membrane. 4. Tat and Rev proteins: These proteins regulate the expression of the HIV genome and the export of viral RNA from the host cell nucleus. Understanding the function of these HIV proteins is important for the development of effective treatments and vaccines against HIV.
The 'vpr Gene Products, Human Immunodeficiency Virus' refers to the proteins encoded by the vpr gene of the human immunodeficiency virus (HIV). The vpr gene is one of the regulatory genes of HIV and is expressed during the late stages of viral replication. The vpr protein is a small, basic protein that is involved in various cellular processes, including nuclear import, apoptosis, and transcriptional regulation. In HIV-infected cells, the vpr protein has been shown to play a role in the pathogenesis of the disease by promoting cell death, impairing immune function, and contributing to the development of neurological complications.
"Gene Products, rev" is not a commonly used term in the medical field. It is possible that it may refer to a specific medical test or procedure that is not widely recognized or used. Without more context or information, it is difficult to provide a more specific definition.
Receptors, CXCR4 are a type of protein found on the surface of certain cells in the human body. These proteins are known as chemokine receptors, and they play a role in regulating the movement of cells within the body. Specifically, CXCR4 receptors are activated by a chemical messenger called CXCL12, which is produced by cells in various tissues throughout the body. When CXCR4 receptors are activated by CXCL12, they trigger a signaling cascade within the cell that can lead to a variety of cellular responses, including changes in cell migration, proliferation, and survival. In the medical field, CXCR4 receptors and their interactions with CXCL12 are of interest because they have been implicated in a number of different diseases and conditions, including cancer, HIV infection, and cardiovascular disease.
HIV Seropositivity refers to the presence of antibodies against the Human Immunodeficiency Virus (HIV) in a person's blood. These antibodies are produced by the immune system in response to the presence of the virus in the body. A positive HIV serology test indicates that the person has been infected with HIV at some point in their life, but it does not necessarily mean that they are currently infected or that they have AIDS. HIV seropositivity is typically diagnosed through a blood test that detects the presence of HIV antibodies in the blood. This test is often used as part of a routine screening for sexually transmitted infections (STIs) or as part of a pre-employment or pre-marriage screening. If a person tests positive for HIV antibodies, they will need to undergo further testing to confirm the diagnosis and determine the stage of their infection.
In the medical field, "Vaccines, Synthetic" refers to vaccines that are made using synthetic or man-made methods, rather than being derived from natural sources such as live or attenuated viruses or bacteria. These vaccines are typically made using recombinant DNA technology, which involves inserting a small piece of genetic material from the pathogen into a harmless host cell, such as a yeast or bacteria, that is then grown in large quantities. The resulting protein is then purified and used to make the vaccine. Synthetic vaccines have several advantages over traditional vaccines, including the ability to produce vaccines quickly and efficiently, the ability to produce vaccines for diseases that are difficult to grow in the laboratory, and the ability to produce vaccines that are safe and effective for people with weakened immune systems or other health conditions. Some examples of synthetic vaccines include the hepatitis B vaccine, the human papillomavirus (HPV) vaccine, and the influenza vaccine.
Organophosphonates are a class of chemical compounds that contain a phosphorus atom bonded to an organic group. They are commonly used as insecticides, herbicides, and as a nerve agent in chemical warfare. In the medical field, organophosphonates are used as medications to treat conditions such as osteoporosis, Paget's disease, and certain types of cancer. They work by inhibiting the activity of an enzyme called alkaline phosphatase, which is involved in bone metabolism. Organophosphonates can also be used as a diagnostic tool to measure the activity of alkaline phosphatase in the body.
DNA primers are short, single-stranded DNA molecules that are used in a variety of molecular biology techniques, including polymerase chain reaction (PCR) and DNA sequencing. They are designed to bind to specific regions of a DNA molecule, and are used to initiate the synthesis of new DNA strands. In PCR, DNA primers are used to amplify specific regions of DNA by providing a starting point for the polymerase enzyme to begin synthesizing new DNA strands. The primers are complementary to the target DNA sequence, and are added to the reaction mixture along with the DNA template, nucleotides, and polymerase enzyme. The polymerase enzyme uses the primers as a template to synthesize new DNA strands, which are then extended by the addition of more nucleotides. This process is repeated multiple times, resulting in the amplification of the target DNA sequence. DNA primers are also used in DNA sequencing to identify the order of nucleotides in a DNA molecule. In this application, the primers are designed to bind to specific regions of the DNA molecule, and are used to initiate the synthesis of short DNA fragments. The fragments are then sequenced using a variety of techniques, such as Sanger sequencing or next-generation sequencing. Overall, DNA primers are an important tool in molecular biology, and are used in a wide range of applications to study and manipulate DNA.
The "vif Gene Products, Human Immunodeficiency Virus" refers to the viral infectivity factor (vif) gene and the proteins it encodes, which are produced by the human immunodeficiency virus (HIV). The vif gene is essential for the replication and survival of HIV in the host cell. It helps to counteract the host's antiviral defenses, particularly the cytosine deaminase enzyme, which is produced by a host protein called APOBEC3G. The vif protein binds to APOBEC3G and prevents it from binding to the viral genome, thereby allowing the virus to replicate and spread. The vif gene and its products are important targets for the development of antiretroviral therapies for HIV.
"Rev Gene Products, Human Immunodeficiency Virus" refers to the regulatory protein encoded by the Rev gene of the Human Immunodeficiency Virus (HIV). The Rev protein plays a crucial role in the replication of HIV by facilitating the export of unspliced and partially spliced viral transcripts from the nucleus to the cytoplasm of infected cells. This is necessary for the production of infectious HIV particles. The Rev protein binds to specific sequences in the viral RNA and interacts with cellular factors to mediate the export of viral transcripts. Dysregulation of the Rev protein can lead to impaired HIV replication and may contribute to the pathogenesis of HIV infection.
Viral vaccines are a type of vaccine that use a weakened or inactivated form of a virus to stimulate the immune system to produce an immune response against the virus. This immune response can provide protection against future infections with the virus. There are several different types of viral vaccines, including live attenuated vaccines, inactivated vaccines, and subunit vaccines. Live attenuated vaccines use a weakened form of the virus that is still able to replicate, but is not strong enough to cause disease. Inactivated vaccines use a killed form of the virus that is no longer able to replicate. Subunit vaccines use only a small part of the virus, such as a protein or a piece of genetic material, to stimulate an immune response. Viral vaccines are used to prevent a wide range of viral diseases, including influenza, measles, mumps, rubella, polio, hepatitis A and B, and human papillomavirus (HPV). They are typically given by injection, but can also be given by mouth or nose in some cases. Viral vaccines are an important tool in preventing the spread of viral diseases and reducing the number of cases and deaths caused by these diseases. They are generally safe and effective, and are an important part of public health efforts to control the spread of viral diseases.
The env gene products of human immunodeficiency virus (HIV) refer to the envelope glycoproteins that are encoded by the env gene in the HIV genome. These proteins are responsible for the attachment and entry of the virus into host cells. The env gene encodes for three proteins: gp120, gp41, and gp37. Gp120 is the primary receptor-binding protein, while gp41 is responsible for fusion of the viral envelope with the host cell membrane. Gp37 is a minor protein that may play a role in viral assembly. The env gene products are highly variable, which allows the virus to evade the host immune system and establish chronic infection. This variability is due to the high rate of mutation in the env gene, as well as the recombination of genetic material between different HIV strains. The env gene products are also the target of the immune response in HIV infection. Antibodies against gp120 and gp41 can neutralize the virus and prevent infection, and are the basis for many HIV vaccines and therapeutic strategies.
HIV Envelope Protein gp160 is a glycoprotein that is found on the surface of the human immunodeficiency virus (HIV). It is a key component of the virus's envelope, which is the outer layer of the virus that surrounds its genetic material. The gp160 protein is composed of two subunits, gp120 and gp41, which are held together by disulfide bonds. The gp160 protein plays a critical role in the virus's ability to infect host cells, as it allows the virus to attach to and fuse with the host cell membrane. Understanding the structure and function of the gp160 protein is important for the development of effective HIV vaccines and antiretroviral therapies.
DNA vaccines are a type of vaccine that uses a small piece of genetic material, usually DNA, to stimulate an immune response in the body. This genetic material is designed to encode a specific protein that is found on the surface of a pathogen, such as a virus or bacteria. When the DNA is introduced into the body, it is taken up by cells and used to produce the protein. The immune system recognizes the protein as foreign and mounts an immune response against it, which can provide protection against future infections by the pathogen. DNA vaccines are still in the experimental stage and have not yet been widely used in humans. However, they have shown promise in preclinical studies and are being investigated as a potential way to prevent a variety of infectious diseases, including influenza, HIV, and malaria. One advantage of DNA vaccines is that they can be easily and quickly produced, and they do not require the use of live or attenuated pathogens, which can be more difficult to work with and may pose a risk of causing disease.
Primate diseases refer to illnesses and infections that are specific to primates, which are a group of mammals that includes humans, monkeys, apes, and lemurs. These diseases can be caused by a variety of agents, including viruses, bacteria, fungi, and parasites. Some examples of primate diseases include: 1. Ebola virus disease: A highly contagious and often fatal viral hemorrhagic fever that affects humans and non-human primates. 2. Monkeypox: A viral infection that is similar to smallpox but is less severe. It is primarily found in primates but can also be transmitted to humans. 3. Cholera: A bacterial infection that causes severe diarrhea and dehydration. It is commonly found in primates in the wild but can also affect humans. 4. Plague: A bacterial infection that is transmitted by fleas and can cause severe illness and death in humans and primates. 5. Leishmaniasis: A parasitic infection that is transmitted by sandflies and can cause skin ulcers, fever, and other symptoms in humans and primates. Primate diseases are of particular concern because they can pose a risk to human health, especially in areas where primates and humans live in close proximity. Additionally, some primate diseases can be difficult to diagnose and treat, making them a significant challenge for healthcare professionals.
Fusion proteins, gag-pol, are a type of protein that are produced by the human immunodeficiency virus (HIV). The gag-pol gene is a single open reading frame that encodes two different proteins: the Gag protein and the Pol protein. The Gag protein is responsible for packaging the viral RNA and other components into a protective capsid, which is the outer shell of the virus. The Pol protein, on the other hand, is responsible for several functions, including reverse transcription of the viral RNA into DNA, integration of the viral DNA into the host cell's genome, and the production of new viral proteins. During the replication cycle of HIV, the gag-pol gene is transcribed into a single mRNA molecule, which is then translated into the Gag and Pol proteins. The Gag and Pol proteins are then cleaved by cellular proteases to produce the individual proteins. Fusion proteins, gag-pol, are of interest in the medical field because they are involved in the replication and pathogenesis of HIV. Understanding the structure and function of these proteins can help researchers develop new treatments for HIV and other viral infections.
Retroviridae infections refer to a group of viral infections caused by retroviruses, which are a type of virus that use an RNA genome to replicate. Retroviruses can infect a wide range of hosts, including humans, animals, and plants. Some common retroviruses that can cause infections in humans include HIV (human immunodeficiency virus), HTLV (human T-cell leukemia virus), and the gammaretroviruses that cause certain types of cancer in cats and dogs. Retroviruses can cause a variety of diseases in their hosts, depending on the specific virus and the host's immune system. For example, HIV can cause acquired immunodeficiency syndrome (AIDS), a condition in which the immune system becomes severely weakened and the body becomes vulnerable to a wide range of infections and cancers. Retroviruses are typically transmitted through contact with bodily fluids, such as blood, semen, or breast milk. They can also be transmitted through sexual contact, sharing needles or other injection equipment, or from mother to child during pregnancy, childbirth, or breastfeeding. Treatment for retroviral infections typically involves antiretroviral therapy (ART), which involves taking a combination of medications to suppress the virus and prevent it from replicating. In some cases, retroviral infections can be cured or managed with appropriate treatment.
HIV protease is an enzyme that is produced by the human immunodeficiency virus (HIV) during the replication of the virus. It plays a crucial role in the maturation of the virus by cleaving specific proteins into smaller, functional units. This process is necessary for the virus to assemble and infect new cells. HIV protease inhibitors are a class of antiretroviral drugs that work by blocking the activity of the enzyme, thereby preventing the virus from maturing and spreading. These drugs are an important part of combination antiretroviral therapy (cART), which is the standard treatment for HIV infection. By inhibiting HIV protease, cART can help to suppress the virus to undetectable levels in the blood, reducing the risk of transmission and slowing the progression of the disease to acquired immunodeficiency syndrome (AIDS).
Adenine is a nitrogenous base that is found in DNA and RNA. It is one of the four nitrogenous bases that make up the genetic code, along with guanine, cytosine, and thymine (in DNA) or uracil (in RNA). Adenine is a purine base, which means it has a double ring structure with a six-membered ring fused to a five-membered ring. It is one of the two purine bases found in DNA and RNA, the other being guanine. Adenine is important in the function of DNA and RNA because it forms hydrogen bonds with thymine (in DNA) or uracil (in RNA) to form the base pairs that make up the genetic code.
In the medical field, "Disease Models, Animal" refers to the use of animals to study and understand human diseases. These models are created by introducing a disease or condition into an animal, either naturally or through experimental manipulation, in order to study its progression, symptoms, and potential treatments. Animal models are used in medical research because they allow scientists to study diseases in a controlled environment and to test potential treatments before they are tested in humans. They can also provide insights into the underlying mechanisms of a disease and help to identify new therapeutic targets. There are many different types of animal models used in medical research, including mice, rats, rabbits, dogs, and monkeys. Each type of animal has its own advantages and disadvantages, and the choice of model depends on the specific disease being studied and the research question being addressed.
AIDS Dementia Complex (ADC) is a neurological disorder that occurs in people with advanced HIV/AIDS. It is characterized by a gradual decline in cognitive function, memory loss, confusion, and changes in personality. ADC is caused by the damage to the brain and nervous system that occurs as a result of HIV infection and the immune system's response to the virus. The symptoms of ADC can range from mild to severe and can affect a person's ability to perform daily activities. Treatment for ADC typically involves managing the underlying HIV infection and addressing the specific symptoms of the disorder.
Membrane glycoproteins are proteins that are attached to the cell membrane through a glycosyl group, which is a complex carbohydrate. These proteins play important roles in cell signaling, cell adhesion, and cell recognition. They are involved in a wide range of biological processes, including immune response, cell growth and differentiation, and nerve transmission. Membrane glycoproteins can be classified into two main types: transmembrane glycoproteins, which span the entire cell membrane, and peripheral glycoproteins, which are located on one side of the membrane.
AIDS-Related Opportunistic Infections (AROIs) are infections that occur when the immune system is weakened due to HIV/AIDS. The immune system is responsible for fighting off infections and diseases, but when it is weakened, it is unable to effectively fight off these infections. As a result, people with HIV/AIDS are more susceptible to a variety of infections that would not normally cause illness in people with a healthy immune system. These infections are called opportunistic infections because they take advantage of the weakened immune system to cause illness. Some common AROIs include pneumonia, tuberculosis, and yeast infections. Treatment for AROIs typically involves antiretroviral therapy (ART) to control the HIV infection and medications to treat the specific infection.
Viral proteins are proteins that are synthesized by viruses during their replication cycle within a host cell. These proteins play a crucial role in the viral life cycle, including attachment to host cells, entry into the cell, replication of the viral genome, assembly of new viral particles, and release of the virus from the host cell. Viral proteins can be classified into several categories based on their function, including structural proteins, non-structural proteins, and regulatory proteins. Structural proteins are the building blocks of the viral particle, such as capsid proteins that form the viral coat. Non-structural proteins are proteins that are not part of the viral particle but are essential for viral replication, such as proteases that cleave viral polyproteins into individual proteins. Regulatory proteins are proteins that control the expression of viral genes or the activity of viral enzymes. Viral proteins are important targets for antiviral drugs and vaccines, as they are essential for viral replication and survival. Understanding the structure and function of viral proteins is crucial for the development of effective antiviral therapies and vaccines.
Severe Combined Immunodeficiency (SCID) is a rare genetic disorder that affects the immune system. It is characterized by a severe and combined deficiency of both T cells and B cells, which are essential components of the immune system that help the body fight off infections and diseases. SCID can be caused by mutations in one of several genes that are involved in the development and function of the immune system. These mutations can result in the inability of the body to produce functional T cells and B cells, leaving the individual vulnerable to infections that would normally be easily fought off by a healthy immune system. Symptoms of SCID can include recurrent and severe infections, failure to thrive, and delayed development. Without treatment, SCID can be life-threatening, but it can be managed with bone marrow transplantation or gene therapy.
Histocompatibility antigens class I (HLA class I) are a group of proteins found on the surface of almost all cells in the human body. These proteins play a crucial role in the immune system by presenting pieces of foreign substances, such as viruses or bacteria, to immune cells called T cells. HLA class I antigens are encoded by a group of genes located on chromosome 6. There are several different HLA class I antigens, each with a unique structure and function. The specific HLA class I antigens present on a person's cells can affect their susceptibility to certain diseases, including autoimmune disorders, infectious diseases, and cancer. In the context of transplantation, HLA class I antigens are important because they can trigger an immune response if the donor tissue is not a close match to the recipient's own tissue. This immune response, known as rejection, can lead to the rejection of the transplanted tissue or organ. Therefore, matching HLA class I antigens between the donor and recipient is an important consideration in transplantation.
Retroviridae Proteins, Oncogenic refers to proteins encoded by retroviruses that have the ability to cause cancer in infected cells. Retroviruses are a type of virus that use RNA as their genetic material and reverse transcribe their RNA genome into DNA, which is then integrated into the host cell's genome. Oncogenic retroviruses can cause cancer by inserting their DNA into the host cell's genome at a specific location, called a viral integration site, which can disrupt the normal functioning of cellular genes and lead to uncontrolled cell growth and division. Examples of oncogenic retroviruses include the human immunodeficiency virus (HIV) and the avian leukosis virus (ALV).
Superinfection is a medical term used to describe the occurrence of a secondary infection in a patient who is already infected with a primary pathogen. This can happen when the immune system is weakened or compromised, making it easier for a new pathogen to enter the body and establish an infection. Superinfections can occur in a variety of ways, including through exposure to a new pathogen, through the use of antibiotics or other medications that disrupt the normal balance of microorganisms in the body, or through the spread of a pathogen from one part of the body to another. Superinfections can be serious and may require prompt medical attention. They can also complicate the treatment of the primary infection, as the new pathogen may be resistant to the same medications that are effective against the primary pathogen.
Recombinant proteins are proteins that are produced by genetically engineering bacteria, yeast, or other organisms to express a specific gene. These proteins are typically used in medical research and drug development because they can be produced in large quantities and are often more pure and consistent than proteins that are extracted from natural sources. Recombinant proteins can be used for a variety of purposes in medicine, including as diagnostic tools, therapeutic agents, and research tools. For example, recombinant versions of human proteins such as insulin, growth hormones, and clotting factors are used to treat a variety of medical conditions. Recombinant proteins can also be used to study the function of specific genes and proteins, which can help researchers understand the underlying causes of diseases and develop new treatments.
Antibodies, neutralizing are proteins produced by the immune system in response to the presence of a foreign substance, such as a virus or bacteria. Neutralizing antibodies are a specific type of antibody that can bind to and neutralize the harmful effects of a pathogen, preventing it from infecting cells or causing damage to the body. Neutralizing antibodies are an important part of the immune response and are often used in medical treatments to help the body fight off infections.
Monoclonal antibodies (mAbs) are laboratory-made proteins that can mimic the immune system's ability to fight off harmful pathogens, such as viruses and bacteria. They are produced by genetically engineering cells to produce large quantities of a single type of antibody, which is specific to a particular antigen (a molecule that triggers an immune response). In the medical field, monoclonal antibodies are used to treat a variety of conditions, including cancer, autoimmune diseases, and infectious diseases. They can be administered intravenously, intramuscularly, or subcutaneously, depending on the condition being treated. Monoclonal antibodies work by binding to specific antigens on the surface of cells or pathogens, marking them for destruction by the immune system. They can also block the activity of specific molecules involved in disease processes, such as enzymes or receptors. Overall, monoclonal antibodies have revolutionized the treatment of many diseases, offering targeted and effective therapies with fewer side effects than traditional treatments.
Disease progression refers to the worsening or progression of a disease over time. It is a natural course of events that occurs in many chronic illnesses, such as cancer, heart disease, and diabetes. Disease progression can be measured in various ways, such as changes in symptoms, physical examination findings, laboratory test results, or imaging studies. In some cases, disease progression can be slowed or stopped through medical treatment, such as medications, surgery, or radiation therapy. However, in other cases, disease progression may be inevitable, and the focus of treatment may shift from trying to cure the disease to managing symptoms and improving quality of life. Understanding disease progression is important for healthcare providers to develop effective treatment plans and to communicate with patients about their condition and prognosis. It can also help patients and their families make informed decisions about their care and treatment options.
Cyclophilin A (CypA) is a protein that is found in many different types of cells in the human body. It is a member of the cyclophilin family of proteins, which are named for their ability to bind to cyclosporine, a drug that is used to prevent organ rejection in transplant patients. CypA plays a number of important roles in the body. One of its main functions is to help regulate the immune system. It does this by interacting with other proteins and helping to control the activity of immune cells. CypA is also involved in the process of cell division and the formation of new blood vessels. In the medical field, CypA is of interest because of its potential role in a number of different diseases. For example, some studies have suggested that CypA may be involved in the development of certain types of cancer, such as breast cancer and prostate cancer. It has also been linked to the progression of HIV infection and the development of kidney disease. Overall, CypA is a complex and multifaceted protein that plays a number of important roles in the body. Further research is needed to fully understand its functions and potential therapeutic applications.
Viral fusion proteins are a class of proteins that are expressed on the surface of enveloped viruses, such as influenza, HIV, and Ebola. These proteins play a critical role in the viral life cycle by facilitating the fusion of the viral envelope with the host cell membrane, allowing the virus to enter the cell and initiate infection. Viral fusion proteins are typically composed of two subunits, a highly conserved heptad repeat region (HR) and a variable ectodomain. The HR region is responsible for mediating the interaction between the viral and host cell membranes, while the ectodomain is responsible for recognizing and binding to specific receptors on the host cell surface. The process of viral fusion involves the conformational change of the viral fusion protein, which leads to the formation of a six-helix bundle structure that brings the viral and host cell membranes into close proximity. This allows the viral envelope to fuse with the host cell membrane, creating a pore through which the viral genome can enter the cell. Viral fusion proteins are a target for antiviral drugs, as they are essential for viral entry and infection. Inhibitors of viral fusion proteins can prevent the virus from entering the cell and can be effective in treating a wide range of viral infections.
In the medical field, a virus disease is a condition caused by a virus, which is a tiny infectious agent that can only replicate inside living cells. Viruses can infect a wide range of organisms, including humans, animals, plants, and even bacteria. When a virus enters the body, it attaches to and invades host cells, taking over the cell's machinery to produce more copies of itself. This can cause damage to the host cells and trigger an immune response, which can lead to symptoms such as fever, cough, sore throat, and fatigue. Some common examples of virus diseases in humans include the common cold, influenza, herpes simplex virus (HSV), human immunodeficiency virus (HIV), and hepatitis B and C. These diseases can range from mild to severe and can be treated with antiviral medications, vaccines, or supportive care.
Interferon-gamma (IFN-γ) is a type of cytokine, which is a signaling molecule that plays a crucial role in the immune system. It is produced by various immune cells, including T cells, natural killer cells, and macrophages, in response to viral or bacterial infections, as well as in response to certain types of cancer. IFN-γ has a wide range of effects on the immune system, including the activation of macrophages and other immune cells, the inhibition of viral replication, and the promotion of T cell differentiation and proliferation. It also plays a role in the regulation of the immune response, helping to prevent excessive inflammation and tissue damage. In the medical field, IFN-γ is used as a therapeutic agent in the treatment of certain types of cancer, such as Hodgkin's lymphoma and multiple myeloma. It is also being studied as a potential treatment for other conditions, such as autoimmune diseases and viral infections.
Cytidine deaminase is an enzyme that plays a crucial role in the metabolism of nucleosides and nucleotides in the body. It catalyzes the conversion of cytidine, a nucleoside found in DNA and RNA, into uridine, another nucleoside. This reaction is an important step in the synthesis of deoxyribonucleotides, which are the building blocks of DNA. Cytidine deaminase is encoded by the CDA gene and is found in many tissues throughout the body, including the liver, spleen, and bone marrow. It is also expressed in certain types of cancer cells, where it can contribute to the development and progression of the disease. In the medical field, cytidine deaminase is of interest because it is involved in the metabolism of several drugs and is a potential target for the development of new therapies. For example, some drugs that are used to treat certain types of cancer, such as gemcitabine and cytarabine, are nucleoside analogs that are activated by cytidine deaminase. By inhibiting this enzyme, it may be possible to increase the effectiveness of these drugs or reduce their toxicity. In addition, cytidine deaminase has been implicated in the development of certain genetic disorders, such as adenosine deaminase deficiency and Cockayne syndrome. In these conditions, mutations in the CDA gene can lead to a deficiency in the enzyme, which can result in a range of symptoms, including developmental delays, neurological problems, and an increased risk of infections.
Recombinant fusion proteins are proteins that are produced by combining two or more genes in a single molecule. These proteins are typically created using genetic engineering techniques, such as recombinant DNA technology, to insert one or more genes into a host organism, such as bacteria or yeast, which then produces the fusion protein. Fusion proteins are often used in medical research and drug development because they can have unique properties that are not present in the individual proteins that make up the fusion. For example, a fusion protein might be designed to have increased stability, improved solubility, or enhanced targeting to specific cells or tissues. Recombinant fusion proteins have a wide range of applications in medicine, including as therapeutic agents, diagnostic tools, and research reagents. Some examples of recombinant fusion proteins used in medicine include antibodies, growth factors, and cytokines.
In the medical field, a peptide fragment refers to a short chain of amino acids that are derived from a larger peptide or protein molecule. Peptide fragments can be generated through various techniques, such as enzymatic digestion or chemical cleavage, and are often used in diagnostic and therapeutic applications. Peptide fragments can be used as biomarkers for various diseases, as they may be present in the body at elevated levels in response to specific conditions. For example, certain peptide fragments have been identified as potential biomarkers for cancer, neurodegenerative diseases, and cardiovascular disease. In addition, peptide fragments can be used as therapeutic agents themselves. For example, some peptide fragments have been shown to have anti-inflammatory or anti-cancer properties, and are being investigated as potential treatments for various diseases. Overall, peptide fragments play an important role in the medical field, both as diagnostic tools and as potential therapeutic agents.
Didanosine, also known by its brand name Videx, is an antiretroviral medication used to treat HIV/AIDS. It is a nucleoside reverse transcriptase inhibitor (NRTI), which means it works by blocking the enzyme reverse transcriptase, which is essential for the replication of the HIV virus. Didanosine is typically used in combination with other antiretroviral medications to help control the virus and prevent the progression of HIV to AIDS. It is usually taken orally in the form of tablets or capsules. Common side effects of didanosine include nausea, vomiting, diarrhea, and headache.
Common Variable Immunodeficiency (CVID) is a rare primary immunodeficiency disorder characterized by low levels of antibodies (immunoglobulins) in the blood. CVID affects the immune system's ability to fight off infections, making individuals with the condition more susceptible to recurrent infections, particularly of the respiratory and gastrointestinal tracts. CVID is caused by mutations in genes that are involved in the production of antibodies. These mutations can affect the development and function of B cells, a type of white blood cell that produces antibodies. As a result, individuals with CVID have a reduced ability to produce antibodies in response to infections or vaccinations. Symptoms of CVID can vary widely and may include recurrent infections, fatigue, and swollen lymph nodes. Treatment for CVID typically involves regular infusions of immunoglobulin replacement therapy to boost the levels of antibodies in the blood and prevent infections. Other treatments may include antibiotics to treat infections and immunosuppressive medications to control inflammation.
Organophosphorus compounds are a class of chemicals that contain a phosphorus atom bonded to one or more organic groups, such as alkyl, aryl, or alkoxy groups. These compounds are widely used in agriculture as pesticides, in the manufacturing of plastics, and as solvents. In the medical field, organophosphorus compounds are primarily used as nerve agents, which are toxic chemicals that interfere with the nervous system by inhibiting the enzyme acetylcholinesterase. This inhibition leads to an accumulation of acetylcholine, a neurotransmitter, in the synapses, causing overstimulation of the nervous system and potentially leading to death. Organophosphorus compounds are also used as medications to treat certain medical conditions, such as myasthenia gravis, a disorder that causes muscle weakness. However, they can also have toxic effects on the body, including nausea, vomiting, diarrhea, dizziness, and respiratory distress.
In the medical field, capsid proteins refer to the proteins that make up the outer shell of a virus. The capsid is the protective layer that surrounds the viral genome and is responsible for protecting the virus from the host's immune system and other environmental factors. There are two main types of capsid proteins: structural and non-structural. Structural capsid proteins are the proteins that make up the visible part of the virus, while non-structural capsid proteins are involved in the assembly and maturation of the virus. The specific function of capsid proteins can vary depending on the type of virus. For example, some capsid proteins are involved in attaching the virus to host cells, while others are involved in protecting the viral genome from degradation. Understanding the structure and function of capsid proteins is important for the development of antiviral drugs and vaccines, as well as for understanding the pathogenesis of viral infections.
Protein precursors are molecules that are converted into proteins through a process called translation. In the medical field, protein precursors are often referred to as amino acids, which are the building blocks of proteins. There are 20 different amino acids that can be combined in various ways to form different proteins, each with its own unique function in the body. Protein precursors are essential for the proper functioning of the body, as proteins are involved in a wide range of biological processes, including metabolism, cell signaling, and immune function. They are also important for tissue repair and growth, and for maintaining the structure and function of organs and tissues. Protein precursors can be obtained from the diet through the consumption of foods that are rich in amino acids, such as meat, fish, eggs, and dairy products. In some cases, protein precursors may also be administered as supplements or medications to individuals who are unable to obtain sufficient amounts of these nutrients through their diet.
AIDS-Related Complex (ARC) is a term that was used in the past to describe a group of symptoms and infections that are similar to those seen in people with AIDS (Acquired Immunodeficiency Syndrome), but do not meet the criteria for a diagnosis of AIDS. People with ARC have a weakened immune system, but their CD4 T-cell count is still above 200 cells/mm3, which is the threshold for a diagnosis of AIDS. Symptoms of ARC can include fever, night sweats, weight loss, fatigue, and recurrent infections such as oral thrush, shingles, and pneumonia. People with ARC may also develop Kaposi's sarcoma, a type of cancer that is common in people with AIDS. ARC was first described in the 1980s, when the AIDS epidemic was just beginning, and it was thought that people with ARC would eventually develop AIDS if they did not receive treatment. However, with the development of antiretroviral therapy (ART), the number of people with ARC has decreased significantly, and most people with ARC are now able to control their symptoms and infections with ART.
Immunologic Deficiency Syndromes (IDS) are a group of disorders that affect the immune system, which is the body's natural defense against infections and diseases. In individuals with IDS, the immune system is either absent or not functioning properly, making them more susceptible to infections and diseases that would not normally pose a threat to healthy individuals. IDS can be classified into primary and secondary immunodeficiencies. Primary immunodeficiencies are genetic disorders that affect the immune system from birth or early childhood, while secondary immunodeficiencies are acquired later in life due to other medical conditions or treatments such as chemotherapy or radiation therapy. Some common examples of IDS include: * Severe Combined Immunodeficiency (SCID): a rare genetic disorder in which the immune system is severely impaired, making individuals highly susceptible to infections. * Common Variable Immunodeficiency (CVID): a primary immunodeficiency characterized by low levels of antibodies in the blood, making individuals prone to recurrent infections. * Wiskott-Aldrich Syndrome (WAS): a primary immunodeficiency characterized by low levels of platelets and recurrent infections. * X-linked Agammaglobulinemia (XLA): a primary immunodeficiency characterized by low levels of antibodies and recurrent infections. Treatment for IDS typically involves immunoglobulin replacement therapy, antibiotics, and other supportive care to manage infections and complications. In some cases, bone marrow transplantation or gene therapy may be considered as a potential cure.
Zalcitabine, also known by its brand name Hivid, is a medication used to treat HIV/AIDS. It is a nucleoside reverse transcriptase inhibitor (NRTI), which means it works by blocking the enzyme reverse transcriptase, which is essential for the replication of the HIV virus. Zalcitabine is typically used in combination with other antiretroviral medications to help control the virus and prevent the progression of HIV/AIDS. It is usually taken by mouth, although it can also be given by injection. Zalcitabine can cause side effects such as nausea, vomiting, diarrhea, headache, and fatigue. It can also increase the risk of certain types of cancer, including liver cancer and certain types of leukemia. Therefore, it is important to carefully monitor patients taking zalcitabine and to follow the recommended dosage and monitoring guidelines.
In the medical field, "Ape Diseases" refers to infectious diseases that are naturally occurring in non-human primates, such as chimpanzees, gorillas, and orangutans. These diseases can be transmitted to humans through direct contact with infected animals or their bodily fluids, or through the consumption of contaminated food or water. Some examples of Ape Diseases include Ebola virus, Marburg virus, and Monkeypox. These diseases can cause a range of symptoms, from mild flu-like illness to severe hemorrhagic fever, and can be fatal in some cases. The study of Ape Diseases is important for public health, as it helps to identify potential threats to human health and to develop strategies for preventing and controlling the spread of these diseases. It is also important for conservation efforts, as the loss of non-human primate populations can have a significant impact on the ecosystem and on the spread of infectious diseases.
Immunoglobulin G (IgG) is a type of protein that is produced by the immune system in response to the presence of foreign substances, such as bacteria, viruses, and toxins. It is the most abundant type of immunoglobulin in the blood and is responsible for the majority of the body's defense against infections. IgG is produced by B cells, which are a type of white blood cell that plays a key role in the immune response. When a B cell encounters a foreign substance, it produces IgG antibodies that can recognize and bind to the substance, marking it for destruction by other immune cells. IgG antibodies can also be transferred from mother to child through the placenta during pregnancy, providing the baby with some protection against infections during the first few months of life. In addition, some vaccines contain IgG antibodies to help stimulate the immune system and provide protection against specific diseases. Overall, IgG is an important component of the immune system and plays a critical role in protecting the body against infections and diseases.
HIV Integrase is an enzyme that plays a critical role in the replication of the human immunodeficiency virus (HIV). It is responsible for integrating the viral genetic material into the host cell's DNA, allowing the virus to evade the host's immune system and continue to replicate. The HIV Integrase enzyme is a dimer, meaning it consists of two identical subunits. It binds to the viral DNA and the host cell's DNA, and then catalyzes the integration of the viral genetic material into the host cell's genome. This process is essential for the survival and replication of the virus, and is a key target for antiretroviral therapy (ART) used to treat HIV infection. HIV Integrase inhibitors are a class of antiretroviral drugs that target this enzyme, preventing the integration of the viral genetic material into the host cell's DNA. These drugs are often used in combination with other antiretroviral drugs to treat HIV infection and to suppress viral replication.
In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.
Receptors, Cytokine are proteins that are present on the surface of cells and are responsible for binding to specific cytokines, which are signaling molecules that play a crucial role in regulating immune responses, cell growth, and differentiation. Cytokine receptors are typically found on the surface of immune cells, such as T cells and B cells, as well as on other cell types, such as endothelial cells and fibroblasts. When a cytokine binds to its specific receptor, it triggers a signaling cascade within the cell that can lead to a variety of cellular responses, such as the activation or suppression of immune cells, the promotion of cell growth or differentiation, or the regulation of inflammation. Dysregulation of cytokine signaling can contribute to a variety of diseases, including autoimmune disorders, cancer, and infectious diseases. Therefore, understanding the function and regulation of cytokine receptors is an important area of research in the medical field.
Receptors, Chemokine are proteins found on the surface of cells that bind to specific chemokines, which are small signaling molecules that play a role in immune cell trafficking and inflammation. These receptors are involved in the regulation of immune cell migration and are important for the recruitment of immune cells to sites of infection or injury. There are several different types of chemokine receptors, each of which is specific to a particular chemokine or group of chemokines. Dysregulation of chemokine receptors has been implicated in a variety of diseases, including cancer, autoimmune disorders, and infectious diseases.
Chemokine CCL4, also known as macrophage inflammatory protein 1β (MIP-1β), is a small protein that plays a role in the immune system. It is a type of chemokine, which are a group of signaling molecules that help to direct the movement of immune cells to specific areas of the body in response to infection or injury. CCL4 is produced by a variety of cells, including macrophages, monocytes, and T cells. It is involved in the recruitment of immune cells to sites of inflammation and is also thought to play a role in the development of certain types of cancer. In the medical field, CCL4 is often studied as a potential target for the treatment of diseases such as cancer, autoimmune disorders, and viral infections. It is also used as a diagnostic marker for certain conditions, such as HIV infection and liver disease.
Indinavir is an antiretroviral medication that is used to treat HIV/AIDS. It is a protease inhibitor, which means that it works by blocking the enzyme HIV uses to replicate itself. This helps to slow the progression of the disease and reduce the amount of virus in the body. Indinavir is typically used in combination with other antiretroviral medications to provide a more effective treatment regimen. It is usually taken orally in the form of tablets.
Macrophage Inflammatory Proteins (MIPs) are a family of small proteins that are produced by macrophages, a type of white blood cell. These proteins play a role in the immune response by promoting inflammation and attracting other immune cells to the site of infection or injury. MIPs are also involved in the regulation of angiogenesis, the formation of new blood vessels, and in the development of certain types of cancer. There are several different types of MIPs, including MIP-1α, MIP-1β, and MIP-2, each with its own specific functions and effects on the immune system.
Dideoxynucleotides are modified nucleotides that lack a hydroxyl group at the 3' carbon of the deoxyribose sugar. They are used as chain terminators in DNA sequencing reactions. In these reactions, dideoxynucleotides are incorporated into the growing DNA strand instead of the regular deoxynucleotides. Since they cannot be extended further, they act as chain terminators, allowing the sequence of the DNA to be determined by identifying the order of the incorporated dideoxynucleotides. Dideoxynucleotides are also used in the treatment of certain viral infections, such as HIV, by inhibiting viral DNA replication.
Hepatitis C is a viral infection that affects the liver. It is caused by the hepatitis C virus (HCV), which is transmitted through contact with infected blood or body fluids. The virus can be transmitted through sharing needles or other equipment used to inject drugs, sexual contact, or from mother to child during childbirth. Hepatitis C can cause a range of symptoms, including fatigue, nausea, abdominal pain, and jaundice. In some cases, the virus can cause chronic liver disease, which can lead to liver failure, cirrhosis, and liver cancer. There are several different strains of the hepatitis C virus, and the severity of the infection can vary depending on the strain and the individual's immune system. Treatment for hepatitis C typically involves antiviral medications, which can help to eliminate the virus from the body and prevent further liver damage. In some cases, a liver transplant may be necessary for people with severe liver damage.
Chemokine CCL5, also known as RANTES (regulated on activation, normal T cell expressed and secreted), is a small protein that plays a role in the immune system. It is a type of chemokine, which are signaling molecules that help to direct the movement of immune cells to specific areas of the body in response to infection or injury. CCL5 is produced by a variety of cells, including immune cells such as T cells, macrophages, and dendritic cells, as well as non-immune cells such as endothelial cells and fibroblasts. It acts on specific receptors on the surface of immune cells to attract them to the site of infection or injury. CCL5 has been implicated in a number of different diseases and conditions, including asthma, chronic obstructive pulmonary disease (COPD), and certain types of cancer. It is also involved in the recruitment of immune cells to sites of inflammation, and has been shown to play a role in the development of autoimmune diseases such as rheumatoid arthritis. Overall, CCL5 is an important molecule in the immune system that helps to regulate the movement of immune cells and plays a role in the body's response to infection and injury.
In the medical field, peptides are short chains of amino acids that are linked together by peptide bonds. They are typically composed of 2-50 amino acids and can be found in a variety of biological molecules, including hormones, neurotransmitters, and enzymes. Peptides play important roles in many physiological processes, including growth and development, immune function, and metabolism. They can also be used as therapeutic agents to treat a variety of medical conditions, such as diabetes, cancer, and cardiovascular disease. In the pharmaceutical industry, peptides are often synthesized using chemical methods and are used as drugs or as components of drugs. They can be administered orally, intravenously, or topically, depending on the specific peptide and the condition being treated.
In the medical field, a syndrome is a set of symptoms and signs that occur together and suggest the presence of a particular disease or condition. A syndrome is often defined by a specific pattern of symptoms that are not caused by a single underlying disease, but rather by a combination of factors, such as genetic, environmental, or hormonal. For example, Down syndrome is a genetic disorder that is characterized by a specific set of physical and intellectual characteristics, such as a flattened facial profile, short stature, and intellectual disability. Similarly, the flu syndrome is a set of symptoms that occur together, such as fever, cough, sore throat, and body aches, that suggest the presence of an influenza virus infection. Diagnosing a syndrome involves identifying the specific set of symptoms and signs that are present, as well as ruling out other possible causes of those symptoms. Once a syndrome is diagnosed, it can help guide treatment and management of the underlying condition.
Nucleocapsid proteins are a group of proteins that are found in the core of the virus particle, specifically in the nucleocapsid. They play a crucial role in the replication and transcription of the viral genome. In the context of medical research, nucleocapsid proteins are often studied as potential targets for antiviral drugs, as well as for the development of diagnostic tests for viral infections. They are also used as markers for the presence of the virus in infected cells.
Cytosine deaminase is an enzyme that catalyzes the conversion of cytosine, a nitrogenous base found in DNA and RNA, to uracil. This enzyme is commonly used in genetic engineering and gene therapy to introduce specific genetic changes into cells. In these applications, cytosine deaminase is often used in combination with a substrate that is toxic to cells, such as 5-fluorocytosine, which is converted to 5-fluorouracil by the enzyme. The accumulation of 5-fluorouracil inside the cell leads to DNA damage and cell death, allowing researchers to selectively kill or modify specific cells.
Viral structural proteins are proteins that make up the physical structure of a virus. They are essential for the virus to function properly and are involved in various stages of the viral life cycle, including attachment to host cells, entry into the cell, replication, and assembly of new virus particles. There are several types of viral structural proteins, including capsid proteins, envelope proteins, and matrix proteins. Capsid proteins form the protective shell around the viral genetic material, while envelope proteins are found on the surface of enveloped viruses and help the virus enter host cells. Matrix proteins are found in the interior of the viral particle and help to stabilize the structure of the virus. Viral structural proteins are important targets for antiviral drugs and vaccines, as they are essential for the virus to infect host cells and cause disease. Understanding the structure and function of viral structural proteins is crucial for the development of effective antiviral therapies and vaccines.
Dideoxynucleosides are modified nucleosides that lack a hydroxyl group at the 3' position of their sugar moiety. They are used as inhibitors of DNA synthesis in the treatment of various viral infections, including HIV and hepatitis B and C. The most commonly used dideoxynucleoside is zidovudine (AZT), which is a component of many antiretroviral drug combinations used to treat HIV infection. Other dideoxynucleosides include stavudine (d4T), didanosine (ddI), and lamivudine (3TC). These drugs work by incorporating into the growing DNA chain and terminating the synthesis process, thereby inhibiting viral replication.
The "pol gene products, human immunodeficiency virus" refers to the proteins encoded by the pol gene of the human immunodeficiency virus (HIV). The pol gene encodes three enzymes that are essential for the replication of the HIV virus: reverse transcriptase, protease, and integrase. Reverse transcriptase is an enzyme that converts the viral RNA genome into DNA, which can then integrate into the host cell's genome. Protease is an enzyme that cleaves the viral polyproteins into individual proteins, which are necessary for the assembly and maturation of new virus particles. Integrase is an enzyme that integrates the viral DNA into the host cell's genome. The pol gene products are therefore critical for the replication and spread of the HIV virus, and are important targets for antiretroviral therapy, which is used to treat HIV infection.
Heterocyclic compounds are organic compounds that contain at least one ring composed of atoms other than carbon. In the medical field, heterocyclic compounds are often used as pharmaceuticals due to their ability to interact with biological targets and produce therapeutic effects. Examples of heterocyclic compounds used in medicine include: 1. Pyrimidines: These are a class of heterocyclic compounds that include thymine, cytosine, and uracil. They are important components of DNA and RNA and are used in the development of antiviral and anticancer drugs. 2. Purines: These are another class of heterocyclic compounds that include adenine and guanine. They are also important components of DNA and RNA and are used in the development of antiviral and anticancer drugs. 3. Imidazoles: These are heterocyclic compounds that contain a nitrogen atom and a carbon atom in a six-membered ring. They are used in the development of antifungal and anti-inflammatory drugs. 4. Quinolines: These are heterocyclic compounds that contain a nitrogen atom and two carbon atoms in a six-membered ring. They are used in the development of antimalarial and antituberculosis drugs. Overall, heterocyclic compounds play an important role in the development of new drugs and therapies in the medical field.
Lamivudine is an antiviral medication that is used to treat HIV/AIDS and chronic hepatitis B virus (HBV) infections. It works by inhibiting the activity of the reverse transcriptase enzyme, which is essential for the replication of both HIV and HBV. Lamivudine is usually taken orally in the form of tablets or capsules, and it is often used in combination with other antiviral medications to increase its effectiveness and reduce the risk of drug resistance. Common side effects of lamivudine include nausea, headache, and fatigue. In rare cases, it can also cause more serious side effects such as liver damage or allergic reactions. Lamivudine is an important medication in the treatment of HIV/AIDS and chronic HBV infections, and it has been shown to be effective in reducing viral load and preventing the progression of these diseases. However, it is important to take the medication as prescribed and to monitor for any potential side effects.
Cytokines are small proteins that are produced by various cells of the immune system, including white blood cells, macrophages, and dendritic cells. They play a crucial role in regulating immune responses and inflammation, and are involved in a wide range of physiological processes, including cell growth, differentiation, and apoptosis. Cytokines can be classified into different groups based on their function, including pro-inflammatory cytokines, anti-inflammatory cytokines, and regulatory cytokines. Pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), promote inflammation and recruit immune cells to the site of infection or injury. Anti-inflammatory cytokines, such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta), help to dampen the immune response and prevent excessive inflammation. Regulatory cytokines, such as interleukin-4 (IL-4) and interleukin-13 (IL-13), help to regulate the balance between pro-inflammatory and anti-inflammatory responses. Cytokines play a critical role in many diseases, including autoimmune disorders, cancer, and infectious diseases. They are also important in the development of vaccines and immunotherapies.
In the medical field, viral core proteins refer to the internal proteins that are essential for the replication and survival of a virus. These proteins are typically found within the viral capsid, which is the protein shell that surrounds the viral genome. The viral core proteins play a crucial role in the viral life cycle by facilitating the replication of the viral genome and the assembly of new virus particles. They may also be involved in protecting the viral genome from degradation or preventing the host immune system from recognizing and eliminating the virus. Examples of viral core proteins include the core protein of the hepatitis B virus, which is essential for the replication of the viral genome, and the core protein of the human immunodeficiency virus (HIV), which plays a role in the assembly of new virus particles. Understanding the structure and function of viral core proteins is important for the development of antiviral drugs and vaccines, as well as for understanding the pathogenesis of viral infections.
Receptors, CCR3 are a type of cell surface receptor that belongs to the chemokine receptor family. They are primarily expressed on immune cells, such as eosinophils, basophils, and mast cells, and play a role in the recruitment and activation of these cells in response to certain chemical signals, such as chemokines. CCR3 receptors are involved in a variety of physiological processes, including inflammation, allergic responses, and the immune response to parasites. They are also implicated in the development of certain diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and certain types of cancer. In the medical field, CCR3 receptors are often targeted in the development of new drugs for the treatment of these conditions. For example, drugs that block CCR3 receptors can help to reduce inflammation and allergic responses, and may be useful in the treatment of asthma and COPD.
Interleukin-2 (IL-2) is a cytokine, a type of signaling molecule that plays a crucial role in the immune system. It is produced by activated T cells, a type of white blood cell that plays a central role in the body's defense against infection and disease. IL-2 has several important functions in the immune system. It promotes the growth and differentiation of T cells, which helps to increase the number of immune cells available to fight infection. It also stimulates the production of other cytokines, which can help to amplify the immune response. IL-2 is used in the treatment of certain types of cancer, such as melanoma and kidney cancer. It works by stimulating the immune system to attack cancer cells. It is typically given as an injection or infusion, and can cause side effects such as fever, chills, and flu-like symptoms. In addition to its use in cancer treatment, IL-2 has also been studied for its potential role in treating other conditions, such as autoimmune diseases and viral infections.
Oligodeoxyribonucleotides (ODNs) are short chains of DNA or RNA that are synthesized in the laboratory. They are typically used as tools in molecular biology research, as well as in therapeutic applications such as gene therapy. ODNs can be designed to bind to specific DNA or RNA sequences, and can be used to modulate gene expression or to introduce genetic changes into cells. They can also be used as primers in PCR (polymerase chain reaction) to amplify specific DNA sequences. In the medical field, ODNs are being studied for their potential use in treating a variety of diseases, including cancer, viral infections, and genetic disorders. For example, ODNs can be used to silence specific genes that are involved in disease progression, or to stimulate the immune system to attack cancer cells.
Encephalitis is a medical condition characterized by inflammation of the brain. It can be caused by a variety of factors, including viral or bacterial infections, autoimmune disorders, or exposure to certain toxins. Symptoms of encephalitis can vary widely and may include fever, headache, confusion, seizures, and changes in behavior or personality. In severe cases, encephalitis can lead to long-term neurological damage or even death. Treatment for encephalitis typically involves addressing the underlying cause of the inflammation and providing supportive care to manage symptoms and prevent complications.
Central Nervous System (CNS) infections refer to infections that affect the brain and spinal cord. These infections can be caused by bacteria, viruses, fungi, or parasites, and can result in a range of symptoms, including fever, headache, nausea, vomiting, seizures, and changes in mental status or behavior. CNS infections can be classified into two main categories: primary and secondary. Primary CNS infections occur when the pathogen directly enters the brain or spinal cord, while secondary CNS infections occur when the pathogen enters the bloodstream and spreads to the brain or spinal cord. Some common examples of primary CNS infections include meningitis (inflammation of the protective membranes surrounding the brain and spinal cord), encephalitis (inflammation of the brain), and brain abscess (a localized collection of pus in the brain). Secondary CNS infections can be caused by a variety of pathogens, including bacteria (such as Streptococcus pneumoniae or Staphylococcus aureus), viruses (such as herpes simplex virus or varicella-zoster virus), and fungi (such as Cryptococcus neoformans). Treatment for CNS infections typically involves the use of antibiotics, antiviral drugs, or antifungal medications, depending on the specific pathogen causing the infection. In some cases, surgery may also be necessary to remove infected tissue or drain abscesses. Early diagnosis and treatment are crucial for preventing complications and improving outcomes.
Pregnancy complications, infectious refers to medical conditions that arise during pregnancy due to infections. These infections can be caused by bacteria, viruses, fungi, or parasites and can have serious consequences for both the mother and the developing fetus. Some common infectious complications of pregnancy include: 1. Urinary tract infections (UTIs): These infections can cause discomfort and pain, but with prompt treatment, they usually do not cause harm to the fetus. 2. Group B streptococcus (GBS) infection: This is a type of bacteria that can cause serious infections in newborns, including meningitis and pneumonia. Women who are pregnant or have recently given birth are screened for GBS and treated with antibiotics if they are found to be carrying the bacteria. 3. Toxoplasmosis: This is an infection caused by the parasite Toxoplasma gondii, which can be transmitted to the fetus through the placenta. It can cause miscarriage, stillbirth, or serious birth defects if left untreated. 4. Rubella (German measles): This is a viral infection that can cause serious birth defects if a pregnant woman is infected during the first trimester of pregnancy. 5. Syphilis: This is a bacterial infection that can be transmitted to the fetus through the placenta and cause serious birth defects if left untreated. Prompt diagnosis and treatment of infectious complications of pregnancy are crucial to ensure the health and well-being of both the mother and the developing fetus.
Saquinavir is an antiretroviral medication used to treat HIV/AIDS. It is a protease inhibitor, which means it works by blocking the enzyme HIV uses to replicate itself. Saquinavir is typically used in combination with other antiretroviral medications to help control the virus and prevent the progression of HIV/AIDS. It is usually taken orally in the form of tablets or capsules. Saquinavir can cause side effects such as nausea, diarrhea, and stomach pain, but these are usually mild and can be managed with medication.
Stavudine, also known by its brand name Zerit, is an antiretroviral medication used to treat HIV/AIDS. It is a nucleoside reverse transcriptase inhibitor (NRTI), which means it works by blocking the enzyme reverse transcriptase, which is essential for the replication of HIV. By inhibiting this enzyme, stavudine slows down the replication of HIV and helps to control the virus in the body. Stavudine is typically used in combination with other antiretroviral medications to provide a more effective treatment for HIV/AIDS. It is usually taken orally in the form of tablets, although it can also be given by injection. Stavudine can cause a range of side effects, including nausea, vomiting, headache, dizziness, and fatigue. It can also cause more serious side effects, such as liver damage, pancreatitis, and peripheral neuropathy (nerve damage). Because of these potential side effects, stavudine is typically only prescribed to people with HIV/AIDS who have not responded to other antiretroviral medications or who have certain other medical conditions that make them unable to tolerate other treatments.
Disease susceptibility refers to an individual's increased risk of developing a particular disease or condition due to genetic, environmental, or lifestyle factors. Susceptibility to a disease is not the same as having the disease itself, but rather an increased likelihood of developing it compared to someone who is not susceptible. Genetic factors play a significant role in disease susceptibility. Certain genetic mutations or variations can increase an individual's risk of developing certain diseases, such as breast cancer, diabetes, or heart disease. Environmental factors, such as exposure to toxins or pollutants, can also increase an individual's susceptibility to certain diseases. Lifestyle factors, such as diet, exercise, and smoking, can also impact disease susceptibility. For example, a diet high in saturated fats and sugar can increase an individual's risk of developing heart disease, while regular exercise can reduce the risk. Understanding an individual's disease susceptibility can help healthcare providers develop personalized prevention and treatment plans to reduce the risk of developing certain diseases or to manage existing conditions more effectively.
Tumor virus infections refer to the presence of viruses that can cause cancer in infected individuals. These viruses are also known as oncoviruses or tumor-inducing viruses. They can infect various types of cells in the body and alter their normal functioning, leading to the development of tumors. There are several types of tumor viruses, including human papillomavirus (HPV), hepatitis B and C viruses (HBV and HCV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV). These viruses can cause various types of cancers, such as cervical cancer, liver cancer, nasopharyngeal cancer, and Kaposi's sarcoma, respectively. Tumor virus infections can be transmitted through various means, including sexual contact, blood transfusions, and mother-to-child transmission. Diagnosis of tumor virus infections typically involves the detection of viral antigens or antibodies in the blood or other bodily fluids. Treatment for tumor virus infections depends on the type of virus and the stage of cancer. In some cases, antiviral medications may be used to control the virus and prevent further spread. In other cases, surgery, radiation therapy, or chemotherapy may be necessary to treat the cancer. Vaccines are also available for some tumor viruses, such as HPV, to prevent infection and reduce the risk of cancer.
RNA, Transfer, Lys refers to a specific type of transfer RNA (tRNA) molecule that is involved in the process of protein synthesis in cells. The "lys" in the name refers to the amino acid lysine, which is one of the 20 different amino acids that are used to build proteins. Transfer RNAs are small RNA molecules that act as adaptors between the genetic code stored in messenger RNA (mRNA) and the amino acids used to build proteins. Each tRNA molecule has a specific sequence of nucleotides that allows it to recognize and bind to a specific codon (a sequence of three nucleotides) on the mRNA molecule. The tRNA molecule then carries the corresponding amino acid to the ribosome, where it is added to the growing protein chain. RNA, Transfer, Lys is a specific tRNA molecule that is responsible for carrying the lysine amino acid to the ribosome during protein synthesis. This molecule is essential for the proper functioning of cells, as lysine is a key component of many proteins and is involved in a variety of cellular processes.
Substance abuse, intravenous refers to the use of drugs or other substances that are injected directly into a vein, typically for the purpose of achieving a high or altering one's state of consciousness. This method of administration can be highly addictive and can lead to a range of health problems, including infections, blood-borne diseases, and overdose. Substance abuse, intravenous is a serious medical condition that requires professional treatment and support.
Ritonavir is an antiretroviral medication used to treat HIV/AIDS. It is a protease inhibitor, which means it works by blocking the enzyme HIV uses to replicate itself in the body. Ritonavir is often used in combination with other antiretroviral drugs to increase their effectiveness and reduce the risk of drug resistance. It is typically taken orally in the form of tablets or capsules. Ritonavir can also be used to treat other viral infections, such as hepatitis C, and to prevent organ transplant rejection.
Nelfinavir is an antiretroviral medication used to treat HIV/AIDS. It is a protease inhibitor, which means it works by blocking the enzyme HIV uses to replicate itself. Nelfinavir is typically used in combination with other antiretroviral medications to help control the virus and prevent the progression of HIV/AIDS. It is usually taken orally in the form of tablets or capsules. Nelfinavir can cause side effects such as nausea, diarrhea, and liver problems, and it may interact with other medications. It is important to take nelfinavir exactly as prescribed by a healthcare provider to ensure its effectiveness and to minimize the risk of side effects.
Nucleoside deaminases are enzymes that catalyze the hydrolysis of nitrogenous bases from nucleosides, resulting in the formation of a free base and a deaminated nucleoside. These enzymes play important roles in various biological processes, including DNA synthesis, RNA metabolism, and the regulation of gene expression. In the medical field, nucleoside deaminases have been studied for their potential therapeutic applications. For example, some nucleoside deaminases have been shown to be involved in the development of certain types of cancer, and inhibitors of these enzymes have been investigated as potential cancer treatments. Additionally, nucleoside deaminases have been used as targets for the development of antiviral drugs, as many viruses rely on the deamination of nucleosides to replicate their genetic material.
In the medical field, "DNA, Recombinant" refers to a type of DNA that has been artificially synthesized or modified to contain specific genes or genetic sequences. This is achieved through a process called genetic engineering, which involves inserting foreign DNA into a host organism's genome. Recombinant DNA technology has revolutionized the field of medicine, allowing scientists to create new drugs, vaccines, and other therapeutic agents. For example, recombinant DNA technology has been used to create insulin for the treatment of diabetes, human growth hormone for the treatment of growth disorders, and vaccines for a variety of infectious diseases. Recombinant DNA technology also has important applications in basic research, allowing scientists to study the function of specific genes and genetic sequences, and to investigate the mechanisms of diseases.
Lectins, C-Type are a type of carbohydrate-binding proteins that are found in a variety of plants, animals, and microorganisms. They are characterized by the presence of a conserved cysteine residue in their carbohydrate recognition domain, which is responsible for their binding specificity to specific carbohydrate structures. C-Type lectins are involved in a wide range of biological processes, including immune response, cell adhesion, and cell signaling. They are also used in medical research and have potential therapeutic applications, such as in the treatment of cancer, infectious diseases, and inflammatory disorders. In the medical field, C-Type lectins are often studied for their ability to bind to specific carbohydrate structures on the surface of cells, which can be used to target and modulate cellular processes. They are also used as diagnostic tools to detect specific carbohydrate structures in biological samples, such as in the diagnosis of certain diseases or to monitor the progression of a disease.
In the medical field, an acute disease is a condition that develops suddenly and progresses rapidly over a short period of time. Acute diseases are typically characterized by severe symptoms and a high degree of morbidity and mortality. Examples of acute diseases include pneumonia, meningitis, sepsis, and heart attacks. These diseases require prompt medical attention and treatment to prevent complications and improve outcomes. In contrast, chronic diseases are long-term conditions that develop gradually over time and may persist for years or even decades.
Hemagglutinin glycoproteins, also known as HA glycoproteins, are a type of protein found on the surface of influenza viruses. These proteins play a crucial role in the ability of the virus to infect host cells. HA glycoproteins are responsible for binding to receptors on the surface of host cells, allowing the virus to enter the cell and replicate. There are 18 different subtypes of HA glycoproteins, which are classified based on their antigenic properties. Each subtype has a unique structure, which allows the immune system to recognize and respond to the virus. HA glycoproteins are also the target of the influenza vaccine, which is designed to stimulate the immune system to produce antibodies against the virus. By recognizing and binding to the HA glycoproteins, these antibodies can prevent the virus from infecting host cells and protect against influenza. In summary, HA glycoproteins are a key component of the influenza virus and play a critical role in its ability to infect host cells. They are also the target of the influenza vaccine and are an important area of research in the development of new treatments for influenza.
Oligonucleotide probes are short, synthetic DNA or RNA molecules that are designed to bind specifically to a target sequence of DNA or RNA. They are commonly used in medical research and diagnostic applications to detect and identify specific genetic sequences or to study gene expression. In medical research, oligonucleotide probes are often used in techniques such as polymerase chain reaction (PCR) and in situ hybridization (ISH) to amplify and visualize specific DNA or RNA sequences. They can also be used in gene expression studies to measure the levels of specific mRNAs in cells or tissues. In diagnostic applications, oligonucleotide probes are used in a variety of tests, including DNA sequencing, genetic testing, and infectious disease diagnosis. For example, oligonucleotide probes can be used in PCR-based tests to detect the presence of specific pathogens in clinical samples, or in microarray-based tests to measure the expression levels of thousands of genes at once. Overall, oligonucleotide probes are a powerful tool in medical research and diagnostic applications, allowing researchers and clinicians to study and understand the genetic basis of disease and to develop new treatments and diagnostic tests.
Immunoglobulin A (IgA) is a type of antibody that plays a crucial role in the body's immune system. It is the most abundant antibody in the mucous membranes, which line the surfaces of the respiratory, gastrointestinal, and genitourinary tracts. IgA is produced by plasma cells in the bone marrow and is secreted into the bloodstream and mucous membranes. It is particularly important in protecting against infections in the respiratory and gastrointestinal tracts, where it helps to neutralize and eliminate pathogens such as bacteria, viruses, and fungi. IgA can also be found in tears, saliva, and breast milk, where it provides protection against infections in the eyes, mouth, and digestive tract. In addition, IgA plays a role in the immune response to certain types of cancer and autoimmune diseases. Overall, IgA is a critical component of the body's immune system and plays a vital role in protecting against infections and diseases.
Nevirapine is an antiretroviral medication used to treat HIV/AIDS. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by blocking the enzyme reverse transcriptase, which is essential for the replication of HIV. Nevirapine is typically used in combination with other antiretroviral drugs to help suppress the virus and prevent the progression of HIV to AIDS. It is usually taken as a pill once a day, although the dosage and frequency may vary depending on the individual and the specific regimen being used.
Immune sera refers to a type of blood serum that contains antibodies produced by the immune system in response to an infection or vaccination. These antibodies are produced by B cells, which are a type of white blood cell that plays a key role in the immune response. Immune sera can be used to diagnose and treat certain infections, as well as to prevent future infections. For example, immune sera containing antibodies against a specific virus or bacteria can be used to diagnose a current infection or to prevent future infections in people who have been exposed to the virus or bacteria. Immune sera can also be used as a research tool to study the immune response to infections and to develop new vaccines and treatments. In some cases, immune sera may be used to treat patients with severe infections or allergies, although this is less common than using immune sera for diagnostic or preventive purposes.
In the medical field, coinfection refers to the simultaneous presence of two or more infections in an individual's body. These infections can be caused by different types of microorganisms, such as bacteria, viruses, fungi, or parasites. Coinfections can occur when an individual is already infected with one pathogen and then becomes infected with another pathogen, or when two or more pathogens enter the body at the same time. Coinfections can complicate the diagnosis and treatment of infections because the symptoms of one infection may mask or overlap with the symptoms of another infection. In some cases, coinfections can also increase the severity of the illness and the risk of complications. For example, coinfection with HIV and tuberculosis can increase the risk of death from tuberculosis. Doctors may use diagnostic tests to identify coinfections, such as blood tests, cultures, or imaging studies. Treatment for coinfections typically involves treating each infection separately, using antibiotics or antiviral medications as appropriate. In some cases, doctors may also prescribe medications to prevent the spread of infection or to manage symptoms.
Chemokine CCL3, also known as macrophage inflammatory protein 1α (MIP-1α), is a type of chemokine protein that plays a role in the immune system. It is produced by various cells, including macrophages, monocytes, and dendritic cells, in response to infection or inflammation. CCL3 functions as a chemoattractant, drawing immune cells to the site of infection or injury. It also has other functions, such as promoting the activation and differentiation of immune cells, and regulating the inflammatory response. In the medical field, CCL3 is often studied in the context of various diseases, including HIV/AIDS, cancer, and autoimmune disorders. For example, high levels of CCL3 have been associated with poor outcomes in HIV/AIDS, and it has been proposed as a potential therapeutic target for the disease. Additionally, CCL3 has been implicated in the development and progression of certain types of cancer, such as breast cancer and lung cancer.
Monomeric GTP-binding proteins, also known as small GTPases, are a family of proteins that play important roles in various cellular processes, including signal transduction, cell motility, and vesicle trafficking. These proteins are characterized by their ability to bind and hydrolyze guanosine triphosphate (GTP), a nucleotide that serves as a molecular switch to regulate the activity of the protein. Monomeric GTP-binding proteins exist in two states: an inactive state in which they are bound to guanosine diphosphate (GDP) and an active state in which they are bound to GTP. The switch between these two states is regulated by a variety of factors, including the binding of ligands, the activity of other proteins, and the presence of specific post-translational modifications. In the active state, monomeric GTP-binding proteins can interact with and regulate the activity of other proteins, often by recruiting them to specific cellular locations or by modulating their activity. This makes these proteins important mediators of cellular signaling pathways and allows them to play a role in a wide range of cellular processes.
Murine Acquired Immunodeficiency Syndrome (MAIDS) is a disease that affects laboratory mice and is caused by a retrovirus called the mouse retrovirus (MRV). It is similar to the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS) in humans. MAIDS is characterized by a gradual decline in the immune system, leading to increased susceptibility to infections and tumors. The virus infects and destroys CD4+ T cells, which are a type of white blood cell that plays a critical role in the immune response. As the number of CD4+ T cells decreases, the immune system becomes weaker, making the animal more vulnerable to infections and diseases. MAIDS is used as a model for studying HIV/AIDS in humans because it shares many similarities with the human disease, including the mechanism of viral infection and the progression of immunodeficiency. Research using MAIDS has contributed to our understanding of the pathogenesis of HIV/AIDS and the development of new treatments for the disease.
Deltaretrovirus infections refer to a group of viral infections caused by viruses belonging to the deltaretrovirus family. These viruses are retroviruses, which means that they use an RNA genome that is reverse transcribed into DNA by the virus's reverse transcriptase enzyme. Deltaretroviruses are known to cause a variety of diseases in humans and animals, including acquired immunodeficiency syndrome (AIDS) in humans and leukaemia in cats. The most well-known member of the deltaretrovirus family is the human immunodeficiency virus (HIV), which is the virus that causes AIDS. Deltaretrovirus infections are typically transmitted through contact with infected bodily fluids, such as blood, semen, vaginal fluids, and breast milk. The viruses can also be transmitted through contaminated needles or other medical equipment. Diagnosis of deltaretrovirus infections typically involves detecting the presence of the virus's genetic material or antibodies to the virus in the patient's blood or other bodily fluids. Treatment for these infections may involve antiretroviral therapy (ART) to suppress the virus's replication and slow the progression of the disease.
Simian immunodeficiency virus
Bonobo
Monkey
Host switch
Chlorocebus
APOBEC3C
CXCR6
GPR15
APOBEC3B
Andrew McMichael
Tshaka Cunningham
Human virome
Western lowland gorilla
T-cell depletion
Inflammation
Todd M. Allen
Nef (protein)
Agile mangabey
Moustached guenon
Structure and genome of HIV
Vanessa M. Hirsch
Orthoretrovirinae
Central chimpanzee
Sooty mangabey
Hanneke Schuitemaker
UC Davis School of Veterinary Medicine
Importin α
Viral infectivity factor
Zuzana Kečkéšová
CCR5
Divergent HIV and Simian Immunodeficiency Virus Surveillance, Zaire - Volume 11, Number 9-September 2005 - Emerging Infectious...
Table 4 - Novel Multiplexed HIV/Simian Immunodeficiency Virus Antibody Detection Assay - Volume 17, Number 12-December 2011 -...
Central African Hunters Exposed to Simian Immunodeficiency Virus
Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody...
Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas :: MPG.PuRe
Balancing trained immunity with persistent immune activation and the risk of simian immunodeficiency virus infection in infant...
"Human Immunodeficiency Virus-1/Simian Immunodeficiency Virus Infection" by Anna Maria Gorska, Maribel Donoso et al.
Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus...
Evaluation of -2 RANTES vaginal microbicide formulations in a nonhuman primate simian/human immunodeficiency virus (SHIV)...
1H magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model. - The Kennedy...
About HIV/AIDS | HIV Basics | HIV/AIDS | CDC
Perspectives in Disease Prevention and Health Promotion Guidelines t
Perspektiven f r die Entwicklung einer HIV-Vakzine
HIV: From Biology to Prevention and Treatment
HIV Prophylaxis in Sexual Assault: Background, Indications, Contraindications
US20120157377A1 - Methods to enhance night vision and treatment of night blindness - Google Patents
Frontiers | Whole-Genome Metagenomic Analysis of the Gut Microbiome in HIV-1-Infected Individuals on Antiretroviral Therapy
Have COVID-19 lockdowns affected our immune systems?
CD8 Intracellular Cytokine Detection Kit Anti-Hu-IFN-γ/CD69/CD8/CD3
Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an...
How We Create--Then Blame--A Viral Underclass
Gun Meme of the Day: Politically Incorrect Edition - The Truth About Guns
WikiGenes
Brain | Worthington Biochemical
Timing of HIV transmission during breastfeeding
B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques | PLOS Pathogens
Topical application of antiretroviral drug combination prevents transmission of (S)HIV - ScienceBlog.com
Despite Countless Changes, Original HIV Infection Lurks Within | URMC Newsroom
Book - Frontiers in HIV Research
| Bentham Science
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Infection15
- Recent HIV infection or divergent HIV or simian immunodeficiency virus (SIV) strains may be responsible for Western blot-indeterminate results on 70 serum samples from Zairian hospital employees that were reactive in an enzyme immunoassay. (cdc.gov)
- Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. (duke.edu)
- Utilizing an infant rhesus macaque model, we have previously shown that this attenuated M. Tuberculosis (AMtb)-simian immunodeficiency virus (SIV) vaccine is immunogenic, and although the vaccine did not prevent oral SIV infection, a subset of vaccinated animals was able to partially control virus replication. (elsevierpure.com)
- Human Immunodeficiency Virus-1/Simian Immunodeficiency Virus Infection" by Anna Maria Gorska, Maribel Donoso et al. (touro.edu)
- To determine the contribution of Panx-1 channels to the pathogenesis of NeuroHIV, we used a well-established model of simian immunodeficiency virus (SIV) infection in macaques (Macaca mulatta) in the presence of and absence of a Panx-1 blocker to later examine the synaptic/axonal compromise induced for the virus. (touro.edu)
- Blocking Panx-1 channels after SIV infection prevented the synaptic and axonal compromise induced by the virus, especially by maintaining the more complex synapses. (touro.edu)
- Methods: The present study used a model of chronic intragastric alcohol administration initiated 3 months before intravenous simian immunodeficiency (SIV) inoculation and continued thereafter throughout the course of SIV infection, to investigate the impact of chronic alcohol binge-like consumption during the initial 10-month asymptomatic phase of SIV infection in nonhuman primate rhesus macaques. (psu.edu)
- Infection with human immunodeficiency virus (HIV) commonly results in neurologic disease called the AIDS dementia complex. (ox.ac.uk)
- The simian immunodeficiency virus (SIV)-infected macaque is an excellent animal model for HIV infection, but neuronal loss has not been demonstrated. (ox.ac.uk)
- In 10-30% of infected subjects, antibodies capable of neutralizing not only the autologous virus but also heterologous viruses are generated, usually following several years of infection [ 2 , 5 , 7 - 13 ]. (plos.org)
- Scientists have been surprised to learn that, despite thousands of changes that viruses like HIV undergo in rapid fashion to evade the body's immune system, the original version that caused the infection is still present in the body months later. (rochester.edu)
- Rather, within two or three weeks of infection, the onslaught of immune cells puts the virus on the run to such an extent that the virus must mutate rapidly to evade the body's defenses. (rochester.edu)
- In the monkeys, those who received a primer vaccine followed by multiple booster shots over the course of a year had a 79% lower per-exposure risk of infection by simian-human immunodeficiency virus (SHIV) than unvaccinated monkeys. (healthday.com)
- Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
- Monkey bites, usually restricted in the US to animal laboratory workers, carry a small risk of herpes simian B virus ( Herpesvirus simiae ) infection, which causes vesicular skin lesions at the inoculation site and can progress to encephalitis, which is often fatal. (msdmanuals.com)
Acquired Immunode3
- If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). (cdc.gov)
- Simian immunodeficiency virus (SIV) belongs to the family Retroviridae (subfamily Lentivirinae) and is closely related to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), the etiologic agents of acquired immunodeficiency syndrome (AIDS). (cdc.gov)
- 1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)
Macaque model2
- 1H magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model. (ox.ac.uk)
- Research on the pigtailed macaque model is particularly relevant because of its similarities with the human menstrual cycle, vaginal architecture and vaginal microbiome, and the ability to conduct efficacy studies with simian-human immunodeficiency virus. (scienceblog.com)
Rhesus macaque2
- Scholars@Duke publication: Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression. (duke.edu)
- Originally reported in 1985, the first isolate from a rhesus macaque was called simian T-lymphotropic virus III (STLV-III) (1). (cdc.gov)
SHIV2
- Evaluation of -2 RANTES vaginal microbicide formulations in a nonhuman primate simian/human immunodeficiency virus (SHIV) challenge model. (bvsalud.org)
- SHIV was used in the research because non-human primates are not susceptible to the HIV-1 virus that infects humans, the researchers explained. (healthday.com)
Macaques3
- Acute damage to the CD4+ T cell and CD20+ B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20-30% of infected animal cohorts. (duke.edu)
- An accelerated model of human immunodeficiency virus central nervous system disease was developed in which more than 90% of infected macaques develop typical simian immunodeficiency virus (SIV) encephalitis with neuronal dysfunction by postinoculation (pi) day 84. (eurekamag.com)
- One week after the first pod-IVR insertion, the macaques received the first of 16 vaginal exposures to 50 TCID50 of SHIV162p3, a chimeric SIV/HIV virus that infects macaques. (scienceblog.com)
Retroviruses2
Lymphotropic virus type1
- Also, SIV is distinct from simian T-cell lymphotropic virus type I (STLY-I) which shares extensive genomic sequences with human T-lymphotropic virus type I and is associated with T-cell lymphomas in nonhuman primates (12). (cdc.gov)
Nonhuman primates2
- Limited data exist concerning the presence or concentration of virus in semen, cervical secretions, saliva, urine, breast milk, and amniotic fluids of experimentally or naturally infected nonhuman primates. (cdc.gov)
- Ling's own basic-science group was seeking to analyze RNA sequencing data while studying simian immunodeficiency virus (SIV) in nonhuman primates, a similar virus to HIV in humans, but was struggling to find a tool capable of analyzing associations between the gut microbiome and disease simultaneously. (embs.org)
Infects1
- The research, which was conducted by scientists at the University of Rochester Medical Center, is based on an analysis of more than 100,000 genetic snippets of a virus known as SIV, or simian immunodeficiency virus, which infects monkeys and is a close cousin of HIV. (rochester.edu)
Primates1
- HIV has probably originated from multiple zoonotic transmissions of Simian Immunodeficiency Virus (SIV) from non-human primates to humans in West and Central Africa. (benthamscience.com)
Infections1
- Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. (elsevierpure.com)
Humans1
- Despite decades of research, there are still no HIV vaccines for humans that can induce the body to make the broadly neutralizing antibodies viewed as capable of conferring protective immunity against the virus. (pennmedicine.org)
Microbiome2
- Correlations were observed between the degree of immunodeficiency and gut microbiome in terms of microbiota composition and metabolic pathways. (frontiersin.org)
- The microbiome has a prominent impact on human health, but with microbiomes each comprising trillions of microorganisms such as bacteria, viruses, protozoa, and fungi, and microbes differing from one person to another, much is left to learn. (embs.org)
Body's immune system2
- HIV (human immunodeficiency virus) is a virus that attacks the body's immune system. (cdc.gov)
- We know that the virus confronts such a strong response from the body's immune system that the virus evolves quickly to cope with it. (rochester.edu)
Vaccine2
- In the NIAID study, experiments in mice and rhesus monkeys showed that the vaccine triggered antibody and cellular immune responses against an HIV-like virus. (healthday.com)
- Importantly, the Env proteins generated in the mice looked very similar to those seen in whole virus, much more so than was seen in prior attempts to produce an effective HIV vaccine, the research team said. (healthday.com)
Monkeys3
- Limited studies of wild-caught African green monkeys from Central Africa indicate a seroprevalence of approximately 30%-50%, apparently without associated immunodeficiency disease. (cdc.gov)
- In the proposed new work, Shaw and his team will seek to induce broadly neutralizing antibodies in rhesus monkeys via laboratory-created simian - human immunodeficiency viruses. (pennmedicine.org)
- It addressed a major problem with SHIVs: the only HIV envelopes that would allow SHIVs to infect rhesus monkeys were artificially adapted to bind to the rhesus CD4 molecule, the primary receptor for the virus. (pennmedicine.org)
Antigens1
- Applications include studies of T-cell responses to antigens, such as herpes viruses, HIV, and tumor antigens. (bdbiosciences.com)
Understood1
- The respective roles of cell-free and cell-associated virus in breast-milk transmission are not known, nor is the association between plasma and milk virus levels understood. (nzdl.org)
Vaccines1
- Instead of the classical types of vaccines such as live and inactivated viruses, several novel immunogens including protein subunit and DNA vaccines as well as viral and bacterial vectors are currently being examined. (aerzteblatt.de)
Progression1
- However, primate studies indicate that prophylactic immunization may slow down progression of immunodeficiency. (aerzteblatt.de)
Viral1
- When you were thinking about writing The Viral Underclass and trying to get to the intersection of how viruses like HIV and COVID have a devastating effect on people of color, the disabled, the impoverished, and so on, when did you come to this eureka idea that you should devote a lot of effort to this? (medscape.com)
Chronic1
- SIV isolates are clearly distinct from Type D primate retrovirus (i.e., simian retrovirus 1)that also causes a form of chronic wasting immunodeficiency disease in several primate species (ll). (cdc.gov)
Serum1
- Low virus-binding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20+ B cells. (duke.edu)
Hepatitis1
- Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers. (bdbiosciences.com)
Bacteria1
- According to MIT Medical , by the time a person reaches adulthood, their immune system has already had exposure to plenty of bacteria and viruses and is able to mount an attack against these invaders. (medicalnewstoday.com)
Infant1
- The portal of entry for the virus via the infant mucosa also merits further investigation. (nzdl.org)
Replication1
- Contributors explore the origins and evolution of HIV, the HIV replication cycle, host-virus interactions, host immune responses, and HIV transmission. (cshlpress.com)
Establish1
- Yet, the virus is able to establish a reservoir somewhere in the body, where it continues to reproduce and does not have to respond to the threat from the immune system," Dewhurst added. (rochester.edu)
Salivary1
- However, HIV transmission is unlikely because the concentration of HIV in saliva is much lower than in blood and salivary inhibitors render the virus ineffective. (msdmanuals.com)
Cytomegalovirus1
- Asanuma H, Sharp M, Maecker HT, Maino VC, Arvin AM. Frequencies of memory T cells specific for varicella-zoster virus, herpes simplex virus, and cytomegalovirus determined by intracellular detection of cytokine expression. (bdbiosciences.com)
Transmission1
- HIV-1 and HIV-2 are believed to be the result of cross-species transmission from simian immunodeficiency virus (SIV)-infected chimpanzees and sooty mangabeys, respectively, which represent 2 (SIVcpz and SIVsm) of the 6 major lentiviral phylogenetic lineages ( 1 , 2 ). (cdc.gov)
Population1
- Background: Alcohol abuse has been reported to have a high prevalence in the human immunodeficiency virus (HIV)-infected population. (psu.edu)
Partially1
- The cell tropism of SIV in culture depends partially on the strain of virus propagated and conditions of cell culture. (cdc.gov)
Cell1
- 1994) by applying cell-free virus on the mucosa. (nzdl.org)
Cells1
- They found that the original portions of the virus degrade 400 times faster in response to CD8 cells than they would have if those cells weren't a factor - what scientists call significant "selective pressure" on the virus. (rochester.edu)