A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
Heterodimers of FLAVONOIDS bound to LIGNANS.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.
Materials in intermediate state between solid and liquid.
A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.

Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. (1/282)

Reduction in serum prostate-specific antigen (PSA) levels has been proposed as an endpoint biomarker for hormone-refractory human prostate cancer intervention. We examined whether a flavonoid antioxidant silibinin (an active constituent of milk thistle) decreases PSA levels in hormone-refractory human prostate carcinoma LNCaP cells and whether this effect has biological relevance. Silibinin treatment of cells grown in serum resulted in a significant decrease in both intracellular and secreted forms of PSA concomitant with a highly significant to complete inhibition of cell growth via a G1 arrest in cell cycle progression. Treatment of cells grown in charcoal-stripped serum and 5alpha-dihydrotestosterone showed that the observed effects of silibinin are those involving androgen-stimulated PSA expression and cell growth. Silibinin-induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin-dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in cyclin D1, CDK4, and CDK6 levels and an induction of Cip1/p21 and Kip1/p27 followed by their increased binding with CDK2. Silibinin treatment of cells did not result in apoptosis and changes in p53 and bcl2, suggesting that the observed increase in Cip1/p21 is a p53-independent effect that does not lead to an apoptotic cell death pathway. Conversely, silibinin treatment resulted in a significant neuroendocrine differentiation of LNCaP cells as an alternative pathway after Cip1/p21 induction and G1 arrest. Together, these results suggest that silibinin could be a useful agent for the intervention of hormone-refractory human prostate cancer.  (+info)

Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. (2/282)

The biochemical influence of flavonolignans from the milk thistle Silybum marianum has been tested on kidney cells of African green monkeys. Two nonmalignant cell lines were selected, with the focus of the work on the fibroblast-like Vero line. Proliferation rate, biosynthesis of protein and DNA, and the activity of the enzyme lactate dehydrogenase (as a measure of the cellular metabolic activity) were chosen as parameters for the effect of the flavonolignans. Silibinin and silicristin show remarkable stimulatory effects on these parameters, mainly in Vero cells; however, isosilibinin and silidianin proved to be inactive. In vitro experiments with kidney cells damaged by paracetamol, cisplatin, and vincristin demonstrated that administration of silibinin before or after the chemical-induced injury can lessen or avoid the nephrotoxic effects. The results warrant in vivo evaluations of the flavonolignan derivatives.  (+info)

Hepatitis C: epidemiology and review of complementary/alternative medicine treatments. (3/282)

Hepatitis C is emerging as a serious worldwide problem. In the United States the current mortality figures may triple in the next ten years, rivaling HIV. The disease has a latency of 10-30 years and symptoms or signs may not appear until cirrhosis is evident. Adequate diagnosis, including liver biopsy, is essential in assessing the current stage of the viral infection and the need for treatment. Hepatitis C may manifest as hepatic fibrosis, cirrhosis, hepatocellular carcinoma, lichen planus, glomerulonephritis, mixed cryoglobulinemia, or porphyria. The hepatic damage is due both to the cytopathic effect of the virus and the inflammatory changes secondary to immune activation. The use of the botanical components glycyrrhizin, catechin, silymarin and phytosterols, and the antioxidants N-acetylcysteine and vitamin E are reviewed for their efficacy in treating chronic hepatitis and affecting liver damage.  (+info)

Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. (4/282)

Polyphenolic antioxidants are being identified as cancer preventive agents. Recent studies in our laboratory have identified and defined the cancer preventive and anticarcinogenic potential of a polyphenolic flavonoid antioxidant, silymarin (isolated from milk thistle). More recent studies by us found that these effects of silymarin are due to the major active constituent, silibinin, present therein. Here, studies are done in mice to determine the distribution and conjugate formation of systemically administered silibinin in liver, lung, stomach, skin, prostate and pancreas. Additional studies were then performed to assess the effect of orally administered silibinin on phase II enzyme activity in liver, lung, stomach, skin and small bowel. For tissue distribution studies, SENCAR mice were starved for 24 h, orally fed with silibinin (50 mg/kg dose) and killed after 0.5, 1, 2, 3, 4 and 8 h. The desired tissues were collected, homogenized and parts of the homogenates were extracted with butanol:methanol followed by HPLC analysis. The column eluates were detected by UV followed by electrochemical detection. The remaining homogenates were digested with sulfatase and beta-glucuronidase followed by analysis and quantification. Peak levels of free silibinin were observed at 0.5 h after administration in liver, lung, stomach and pancreas, accounting for 8.8 +/- 1.6, 4. 3 +/- 0.8, 123 +/- 21 and 5.8 +/- 1.1 (mean +/- SD) microg silibinin/g tissue, respectively. In the case of skin and prostate, the peak levels of silibinin were 1.4 +/- 0.5 and 2.5 +/- 0.4, respectively, and were achieved 1 h after administration. With regard to sulfate and beta-glucuronidate conjugates of silibinin, other than lung and stomach showing peak levels at 0.5 h, all other tissues showed peak levels at 1 h after silibinin administration. The levels of both free and conjugated silibinin declined after 0.5 or 1 h in an exponential fashion with an elimination half-life (t((1/2))) of 57-127 min for free and 45-94 min for conjugated silibinin in different tissues. In the studies examining the effect of silibinin on phase II enzymes, oral feeding of silibinin at doses of 100 and 200 mg/kg/day showed a moderate to highly significant (P < 0.1-0.001, Student's t-test) increase in both glutathione S-transferase and quinone reductase activities in liver, lung, stomach, skin and small bowel in a dose- and time-dependent manner. Taken together, the results of the present study clearly demonstrate the bioavailability of and phase II enzyme induction by systemically administered silibinin in different tissues, including skin, where silymarin has been shown to be a strong cancer chemopreventive agent, and suggest further studies to assess the cancer preventive and anticarcinogenic effects of silibinin in different cancer models.  (+info)

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. (5/282)

Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) that has anti-inflammatory, cytoprotective, and anticarcinogenic effects. How silymarin produces these effects is not understood, but it may involve suppression of NF-kappa B, a nuclear transcription factor, which regulates the expression of various genes involved in inflammation, cytoprotection, and carcinogenesis. In this report, we investigated the effect of silymarin on NF-kappa B activation induced by various inflammatory agents. Silymarin blocked TNF-induced activation of NF-kappa B in a dose- and time-dependent manner. This effect was mediated through inhibition of phosphorylation and degradation of Iota kappa B alpha, an inhibitor of NF-kappa B. Silymarin blocked the translocation of p65 to the nucleus without affecting its ability to bind to the DNA. NF-kappa B-dependent reporter gene transcription was also suppressed by silymarin. Silymarin also blocked NF-kappa B activation induced by phorbol ester, LPS, okadaic acid, and ceramide, whereas H2O2-induced NF-kappa B activation was not significantly affected. The effects of silymarin on NF-kappa B activation were specific, as AP-1 activation was unaffected. Silymarin also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. Silymarin suppressed the TNF-induced production of reactive oxygen intermediates and lipid peroxidation. Overall, the inhibition of activation of NF-kappa B and the kinases may provide in part the molecular basis for the anticarcinogenic and anti-inflammatory effects of silymarin, and its effects on caspases may explain its role in cytoprotection.  (+info)

Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. (6/282)

Multidrug resistance pumps (MDRs) protect microbial cells from both synthetic and natural antimicrobials. Amphipathic cations are preferred substrates of MDRs. Berberine alkaloids, which are cationic antimicrobials produced by a variety of plants, are readily extruded by MDRs. Several Berberis medicinal plants producing berberine were found also to synthesize an inhibitor of the NorA MDR pump of a human pathogen Staphylococcus aureus. The inhibitor was identified as 5'-methoxyhydnocarpin (5'-MHC), previously reported as a minor component of chaulmoogra oil, a traditional therapy for leprosy. 5'-MHC is an amphipathic weak acid and is distinctly different from the cationic substrates of NorA. 5'-MHC had no antimicrobial activity alone but strongly potentiated the action of berberine and other NorA substrates against S. aureus. MDR-dependent efflux of ethidium bromide and berberine from S. aureus cells was completely inhibited by 5'-MHC. The level of accumulation of berberine in the cells was increased strongly in the presence of 5'-MHC, indicating that this plant compound effectively disabled the bacterial resistance mechanism against the berberine antimicrobial.  (+info)

Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. (7/282)

In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg prior to BPO resulted in a highly significant protection against BPO-induced tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin. The preventive effect of silymarin was evident in terms of a 70% reduction (P < 0.001) in tumor incidence, a 67% reduction (P < 0.001) in tumor multiplicity and a 44% decrease (P < 0.001) in tumor volume/tumor. In oxidative stress studies, topical application of BPO resulted in 75, 87 and 61% depletion in superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX) activities in mouse epidermis, respectively. These decreases in antioxidant enzyme activities were significantly (P < 0.005-0.001) reversed by pre-application of silymarin in a dose-dependent manner. The observed effects of silymarin were 18-66, 32-72 and 20-67% protection against BPO-induced depletion of SOD, catalase and GPX activity in mouse epidermis, respectively. Silymarin pre-treatment also resulted in a dose-dependent inhibition (35-87%, P < 0.05-0. 001) of BPO-induced lipid peroxidation in mouse epidermis. In inflammatory response studies, silymarin showed a strong inhibition of BPO-induced skin edema (62-85% inhibition, P < 0.001), myeloperoxidase activity (42-100% inhibition, P < 0.001) and interleukin-1alpha protein level in epidermis (36-81% inhibition, P < 0.001). These results, together with our other recent studies, suggest that silymarin could be useful in preventing a wide range of carcinogen and tumor promoter-induced cancers.  (+info)

Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation. (8/282)

Tacrine (THA), used in the treatment of Alzheimer's disease, is known to induce hepatotoxicity, the mechanisms of which remain to be fully established. We have previously shown that THA reduced intracellular glutathione concentration in rat hepatocytes in primary culture, thus pointing to a possible role for oxidative stress in THA toxicity. To test this, the effects of antioxidant molecules, namely, the flavonoids silibinin, silibinin dihydrogensuccinate, and silymarin, were evaluated on the toxicity of THA in cultured rat hepatocytes. This toxicity was investigated after a 24-h treatment over a concentration range from 0 to 1 mM, in the presence or absence of antioxidant (1 and 10 microM). We found that simultaneous treatment of hepatocytes with any of the antioxidants and THA remained ineffective on the lactate dehydrogenase release induced by THA. Then, the production of lipid-derived radicals (to estimate lipid peroxidation) was measured in THA (0.05-0.50 mM)-treated cells using a spin-trapping technique coupled to electron paramagnetic resonance (EPR) spectroscopy. No increase of the EPR signal was observed over the period of 30 min to 24 h. In contrast, treatment of cells with the spin label 12-doxyl stearic acid followed by EPR spectroscopy showed that THA (0.05 and 0.25 mM) rapidly increased hepatocyte membrane fluidity. Extracellular application of GM1 ganglioside (60 microM) both reversed this increase in fluidity and partially reduced lactate dehydrogenase release on THA exposure. In conclusion, this work indicates that early alterations of membrane fluidity, not resulting from lipid peroxidation, are likely to play an important role in the development of THA toxicity.  (+info)

Elicitation with middle-viscous chitosan (30 mg/50 mL) significantly stimulated silymarin synthesis in Silybum marianum hairy root cultures. The root cultures established by infection with Agrobacterium rhizogenes AR15834 showed a potential for production of silymarin. Elicitation with medium molecular weight of chitosan (0, 5, 10, 20, and 30 mg/50 mL) was used in order to improve silymarin production. Total silymarin increased about 5.26-fold after 96 h of treatment with 30 mg/50 mL chitosan. Dry weight of the hairy roots reached the highest point (0.530 and 0.535 g) after 96 h in presence of 20 and 30 mg/50 mL chitosan, respectively. Five different flavonolignans were isolated; taxifolin, silychristin, silydianin, silybin and isosilybin) 0.133, 0.200, 0.120, 0.041 and 0.056 mg/g dry weight, respectively). 30 days old hairy roots were treated by 30 mg/50 mL chitosan in different times (12, 24, 48, 72, 96 and 120 h). The amount of silymarin accumulation significantly increased (0.705 mg/gDW) in hairy
Objective(s): Aspiration is a common cause of acute lung injury (ALI), which lacks an effective treatment. Inflammation and oxidative stress play key roles in ALI development. Silymarin is an active extract of Silybum marianum plant seeds (milk thistle). Silymarin has potent anti-inflammatory and antioxidant effects; however its role in aspiration induced ALI has not been investigated. The aim of this study is to investigate the role of silymarin in the treatment of hydrochloric acid (HCl) aspiration induced ALI and explores its mechanisms of action. Materials and Methods: The study included three groups of rats: Control non-treated group, ALI group (intra-tracheal HCl injected), and silymarin treated ALI group. White blood cells (WBCs) with differential count, oxidative stress parameters, B-cell lymphoma 2 (Bcl-2), transforming growth factor-beta (TGF-β), cyclooxygenase 2 (COX-2), nuclear factor erythroid 2-related factor-2 (Nrf-2), and heme oxygenase-1 (HO-1) were investigated. Lung tissue
Aim and Background: Inflammation is a multiphasic pathophysiological process in which many inflammatory mediators such as histamine, bradycin, prostaglandins, and inflammatory cytokines, such as tumor necrosis factor alpha and interleukins, are involved. In this study, the effects of silymarin on inflammatory factors of TNF-α and albumin-phase proteins in type 1 diabetic rats ...
Because silymarin exhibits anticarcinogenic, anti-inflammatory, and cytoprotective effects, we hypothesized that these effects of silymarin are mediated through suppression of NF-κB activation, an early mediator of the pleiotropic effects of TNF. Our results clearly demonstrate that silymarin is a potent inhibitor of NF-κB activation induced by a wide variety of inflammatory agents. The inhibition of NF-κB activation by silymarin correlated with suppression of IκBα phosphorylation and degradation, p65 nuclear translocation, and NF-κB-dependent reporter gene transcription. Silymarin also inhibited the activation of MEK and JNK and the apoptosis induced by TNF.. There are several possibilities for how silymarin might inhibit TNF-induced NF-κB activation. We showed that silymarin does not interfere with the binding of NF-κB to the consensus DNA binding site. NF-κB activation requires sequential phosphorylation, ubiquitination, and degradation of IκBα. Because silymarin blocks IκBα ...
Silymarin and green tea are the two most widely used botanical products used by patients with chronic hepatitis C virus (HCV) infection. A major limitation of prior clinical investigations that may account for lack of efficacy is their use of inadequate customary oral dose regimens. Ongoing Phase II studies utilizing higher than customary doses of silymarin are based on potential disease modifying effects resulting from the potent antioxidant properties of silymarin flavonolignans. Since patients often use more than one herbal product to self-treat their disease, the use of higher than customary doses of silymarin may change silymarins potential for herbal-herbal interactions. Pharmacokinetic interactions between silymarin and green tea catechins may change their safety/tolerability profiles, and may increase their antioxidant effects through additive or synergistic pharmacodynamic interactions. The objective of this double blind, active placebo controlled, randomized clinical trial is to ...
Silymarin and green tea are the two most widely used botanical products used by patients with chronic hepatitis C virus (HCV) infection. A major limitation of prior clinical investigations that may account for lack of efficacy is their use of inadequate customary oral dose regimens. Ongoing Phase II studies utilizing higher than customary doses of silymarin are based on potential disease modifying effects resulting from the potent antioxidant properties of silymarin flavonolignans. Since patients often use more than one herbal product to self-treat their disease, the use of higher than customary doses of silymarin may change silymarins potential for herbal-herbal interactions. Pharmacokinetic interactions between silymarin and green tea catechins may change their safety/tolerability profiles, and may increase their antioxidant effects through additive or synergistic pharmacodynamic interactions. The objective of this double blind, active placebo controlled, randomized clinical trial is to ...
Silymarin is a flavonoid compound derived from milk thistle that supports liver function and enhances detoxification pathways. It is also used to support the gallbladder, kidneys, and spleen. Silymarin prevents the depletion of the intracellular antioxidant, glutathione, within liver cells, thereby enhancing detoxification and protecting cells from free radical activity.. Due to its variety of functions, the Silymarin Forte formula makes a potent addition to any liver support and detoxification program. Silymarin has a well-established safety profile and a long history of medicinal use. The Silymarin Forte formula includes 200 mg milk thistle per capsule, standardized to 80% silymarin.. Suggested Use:. 1 capsule three times per day or as recommended by your health care professional. ...
In the present study, dietary administration of 500 ppm silymarin during the promotion phase of DMAB-induced prostatic carcinogenesis significantly inhibited the incidence of prostatic adenocarcinoma. Silymarin is known to inhibit chemically induced carcinogenesis in skin (13), tongue (23), urinary bladder (24), and colon (25). Furthermore, Singh et al. (30) reported that the preventive and therapeutic efficacy of dietary feeding of silibinin on human prostate carcinoma DU145 tumor xenograft in athymic nude mice. These results indicate that silymarin might be a candidate chemopreventive agent against carcinogenesis in multiple organs including prostate.. Several mechanisms by which chemopreventive agents exert their inhibitory effects on tumorigenesis could be considered. Cell proliferation plays an important role in multistage carcinogenesis and involves multiple genetic alterations (31, 32). Silymarin and silibinin are reported to suppress the growth of different cancer cells (17, 33-35). ...
In the present study, we evaluated the stage-specific efficacy of silibinin treatment against PCa growth and progression in TRAMP mice. Silibinin was fed to TRAMP mice at different stages of prostate tumor development, and then its inhibitory effect on tumor growth, progression, invasion, migration, and metastasis was evaluated together with the analyses of the molecules possibly involved with silibinin efficacy. Silibinin feeding to mice in 4-12-week group did not show any drastic effect; however, delayed the onset of neoplastic characteristics in some glands as observed by less percentage of glands involved in PIN compared with positive control group showing 100% glands with PIN characteristics. This observation was supported by a moderate decrease in proliferation index, and at molecular level, by inhibitory effect on the expression of some of the cell cycle regulatory molecules. In the 12-20-week group, it was anticipated that all mice would have developed PIN at the time of starting ...
TY - JOUR. T1 - The interaction of flavonoids with membranes. T2 - Potential determinant of flavonoid antioxidant effects. AU - Erlejman, A. G.. AU - Verstraeten, S. V.. AU - Fraga, C. G.. AU - Oteiza, P. I.. PY - 2004/12. Y1 - 2004/12. N2 - Twenty six phenolic substances including representatives of the families, flavanones, flavanols and procyanidins, flavonols, isoflavones, phenolic acids and phenylpropanones were investigated for their effects on lipid oxidation, membrane fluidity and membrane integrity. The incubation of synthetic phosphatidylcholine (PC) liposomes in the presence of these phenolics caused the following effects: (a) flavanols, their related procyanidins and flavonols were the most active preventing 2,2′-azo-bis (2,4-dimethylvaleronitrile) (AMVN)-induced 2-thiobarituric acid-reactive substances (TBARS) formation, inducing lipid ordering at the water-lipid interface, and preventing Triton X-100-induced membrane disruption; (b) all the studied compounds inhibited lipid ...
Thioacetamide (TAA) is one of the common fungicidal agents that induce liver injury varying from inflammation, necrosis, and fibrosis to cirrhosis. Many recent studies reported the beneficial effect of probiotics and silymarin on hepatotoxicity regardless the causative agents. Therefore, the present study aimed to evaluate the ameliorative role of probiotics and/or silymarin on TAA induced hepatotoxicity in rats via histological, and immunohistochemical methods. Twenty five male albino rats were used for this experiment and were divided into five groups (n=5 rats/group); group I acts as negative control, group II was orally administrated distilled water for six weeks, then injected with TAA (200 mg/kg b.wt./ 5 ml physiological saline/ I.P.) twice a week for another six weeks, group III was treated with probiotics at a dose of 135 mg/ kg b.wt. orally in drinking water daily for six weeks, then injected with TAA (dosage of group II), twice weekly for another six weeks, group IV was treated with ...
Studies have shown that silymarin is effective in improving the survival of patients with severe fatty liver disease and/or liver cirrhosis. One study subjected 170 patients to a thrice a day 140 mg silymarin regimen for 41 months. The study showed that those who received silymarin supplementation had a 58 percent 4-year survival rate while the placebo group only had 39 percent. This improvement in survival rates is even more apparent among those who had alcoholic cirrhosis. Silymarin moreover did not present any form of side effect. This particular study attests to the benefit and safety of the supplement for long-term treatments especially for alcoholic patients ...
Silibinin, a natural flavonolignan, induces apoptosis in human bladder transitional-cell papilloma RT4 cells both in vitro and in vivo; however, mechanisms of such efficacy are not completely identified. Here, we studied the mechanisms involved in silibinin-induced apoptosis of RT4 cells having intact p53. Silibinin increased p53 protein level together with its increased phosphorylation at serine 15, activated caspase cascade and caused Bid cleavage for apoptosis. Silibinin-caused p53 activation was mediated via ATM-Chk2 pathway, which in turn induced caspase 2-mediated apoptosis. Pifithrin-α, a p53 inhibitor, reversed silibinin-induced caspase activation including caspase 2; however, caspase 2 inhibitor also reversed p53 phosphorylation suggesting a bidirectional regulation between them. Further, silibinin caused a rapid translocation of p53 and Bid into mitochondria leading to increased permeabilization of mitochondrial membrane and cytochrome c release into the cytosol. JNK1/2 activation was ...
Endothelial dysfunction plays a pivot role in the initiation of the cascade of events leading to CVD [3]. ADMA is an eNOS inhibitor whose levels rise in a number of pathological conditions associated with endothelial dysfunction, including diabetes, dyslipidemia and obesity [9, 10]. In type 2 diabetes, ADMA levels are associated with macrovascular diseases independently of traditional cardiovascular risk factors [15] and ADMA pathway has been proposed as a link between inflammation and endothelial dysfunction [27].. In this study, we report, for the first time, the association of ADMA levels with endothelial dysfunction in db/db mice and demonstrated that silibinin, a worldwide-used flavolignan from milk thistle, favorably impacts on ADMA levels and improves endothelial dysfunction. We found that db/db mice exhibit, both in plasma and aorta, ADMA levels higher than db/m mice. In silibinin-treated db/db, the substantial reduction of plasma and vascular ADMA is associated with the improvement of ...
The effect of silymarin on liver damage induced by acetaminophen (APAP) intoxication was studied. Wistar male rats pretreated (72 h) with 3-methylcholanthrene (3-MC) (20 mg kg-1 body wt. i.p.) were divided into three groups: animals in group 1 were treated with acetaminophen (APAP) (500 mg kg-1 body …
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Silybin P-64 specifications & features from suppliers/manufacturer Silibinin (Silybin, Silybine) CAS NO. : 22888-70-6Appearance: Similar to white powder, odorless, bitter in taste. Silybin is the main effective ingredient of Silymarin, it is extracted from the seeds of composite plant Silybum Marianum, including Sil
Silymarin is a natural compound called a flavonoid, which happens to have antioxidant and liver protecting activities. Over many years, it has been proposed as a complementary medicine to reduce the liver injury produced by other medications. Interestingly, it happens to have anti-inflammatory properties and the ability to kill some bacteria. This flavonoid, Silymarin, is found in Milk Thistle… as well as Cannabis..and it seems to have a significant therapeutic effect []administered alone, or in combination with chemotherapy, in [helping to treat] tuberculosis caused by drug-sensitive or drug-resistant strains[, findings represented here in both] in vitro and in vivo studies. For many years, Tuberculosis (TB) has been a devastating public health problem, internationally. The treatment of this bacteria has been very limited and loaded with challenges. There is a constant cat/mouse chase between nature and human medicine, as the bacteria continually evolves to out-compete new drugs that are ...
The potential benefits of silymarin in the clinical treatment of liver diseases remained a controversial issue. Our current studies provide in vivo evidence demonstrating that silymarin has therapeutic effects on the early stages of liver damage, involving the reversal of fatty changes and a regression of the liver morbid histopathology. Silymarin is composed mainly of silibinin and smaller amounts of a number of other steroisomers ( 16). The silymarin used in the present study contains 55.1% silibinin, as analyzed by high-performance liquid chromatography (data not shown). Previous studies have indicated comparable effects for silymarin and silybinin on the antioxidative properties and growth inhibition of cancer cells ( 17, 31, 32). It is not clear at present whether one, more than one, or various combinations of silymarin components are the active agent of the in vivo efficacy of the mixture. We are currently working on the purification of individual components that are not commercially ...
There is evidence that suggests that Silymarin might have anti fibrotic, anti inflammatory, anti proliferative and immunomodulating effects
Flavonoids are a group of plant compounds that we usually obtain from our diet as part of the vegetables and fruit we eat. These flavonoids are very important for our health because they are natural antioxidants and anti-inflammatories. Another good source of flavonoids is the bark of pine trees, which is why Enzogenol is extracted from the pine bark. Hence, Enzogenol is a highly concentrated mixture of these natural antioxidant and anti-inflammatory flavonoid compounds.. Diet and Health. Research has shown that a diet rich in fruits and vegetables has significant protective effects against many diseases including cancer, heart disease, Alzheimer and others. This is a well established fact that has been shown in over one hundred epidemiological studies on diet and health.. Flavonoids in Fruits and Vegetables. Much of the disease protection from eating lots of fruits and veggies is due to the plant nutrient compounds known as flavonoids.. There are many different flavonoids and their type and ...
Silymarin hepatoprotective effect of Carsil on laboratory animal models of liver intoxication, comparable to the human liver diseases, have been performed in order to prove effectiveness.
Silymarin, an extract of milk thistle commonly used to treat chronic liver disease by millions of people around the World, does not offer significant improvements for patients, according to a new study conducted by a nationwide group of researchers including faculty at the Perelman School of Medicine at the University of Pennsylvania.
Silymarin Benefits from Milk Thistle Extract. Uses for liver health, acne, skin, diabetes, alcohol detox plus dosages, reviews and side effects reported.
Futurebiotics Silymarin Plus 60 tabs Standardized Milk Thistle Extract with Co-Factors Nutritionally Supports Healthy Liver Function* ...
Epigallocatechin-3-gallate (EGCG) is a major ingredient of green tea (GT) and Silibinin, the active component of Silymarin presumably hold a potential to prevent pathogenomics. Prostate cancer aggressiveness is triggered by fusion transcripts formed because of genomic instability induced by juxtapositioning of two genes. An abolished ATM dynamics is incapable of safeguarding integrity of DNA. In agreement with this assumption ATM and DNA PK were impaired in LNCaP cell line to confirm a tight interaction of ATM and DNA PK with the expression profile of TMPRSS2-ERG. Abolished ATM proved instrumental to expression of the fusion transcript. Similarly blunting of DNA PK downregulated the expression of the fusion transcript giving a notion that it is involved in the chromosomal translocation. LNCaP cell lines were analyzed for the effect of EGCG and silibinin on the expression profile of TMPRSS2-ERG. In this particular unprecedented study treatment of the LNCaP cell line with EGCG and Silibilin ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Phase I/II Trials of Silymarin for Chronic Liver Diseases RFA-AT-05-006. NCCAM
Phytochemicals Online : Silymarin - Botanical Source Compound Types TCM Compounds Library Bulk Products CP Phytochemicals High Quality Extracts New products ,DSLR Camera Accessories
The high prevalence of liver diseases such as chronic hepatitis and cirrhosis underscores the need for efficient and cost-effective treatments. The potential benefit of silymarin (extracted from the...
Filipinos here and abroad are purchasing Liveraide Silymarin as part of their being health conscious. Health supplements do a lot for the well being of the body especially when accompanied by a healthy lifestyle - meaning no smoking, reduced alcohol drinking, limited fatty food intake and lots of exercise.. Proven scientific tests show that Silymarin helps to treat different kinds of liver diseases including Hepatitis, Psoriasis and Cirrhosis. Liveraide, whose main component is Silymarin protects the liver by keeping the outer membranes of liver cells healthy, thus preventing toxins from entering. Silymarin also acts to help regenerate and repair liver cells.. If you value a more natural approach in keeping health, then Liveraide is just one of the supplements you need. Liveraide is rich with antioxidants, a component that prevents cell destruction. Liveraide also helps flush away toxins that may damage cells in different organs of the body. Liveraide consumers testify in TV ads, printed media ...
Paper:Silymarin protects the histological pattern of rat liver against radiation toxicity , Author:Samir A. Nassar, Omar I. Ghonemy, Sabry S. El-Serafy, Hamid M. Roushdy and Amr M, Abd-El-Hady , Year:2008 , Faculty of Science ,Department of Zoology ,Benha University
Shop for Source Naturals Silymarin Plus Tablets - 30 Ea from Liver Health, Prostate. Browse other items form Source Naturals Liver Support
This study is the first examining the interplay between Slit2 -Robo1-CXCR4 proteins and silymarin in DU145 cells. We believe that our study will provide new insights for future studies....
Carsil Silymarin table of contents, mechanism of action, pharmacology and pharmacokinetics, clinical use of Carsil addressed. Administration and indications.
Background Melasma is an acquired increased pigmentation of the skin characterized by symmetrical and confluent grey-brown patches usually on the areas of the face exposed to the sun. Silymarin...
食品、饮料与营养保健品 (China Panjin Shengbo Silymarin Extracting Co., Ltd.) | 食品、饮料与营养保健品 一站式进行配方,数据表,物质安全数据表搜索,产品特性和样品申请 -- 免费使用
A05BA03 - Silymarin. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs classified in groups at five different levels.
Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.
IdB 1016 is a complex of silybin (the main active component of silymarin) and phosphatidylcholine, which in animal models shows greater oral bioavailability and therefore greater pharmacological activity compared with pure silybin and silymarin. In order to assess its pharmacokinetic profile in man, …
Treatment Hepatitis A usually clears up on its own and does not require treatment. Those individuals with hepatitis A should make sure to get plenty of rest and avoid drinking any alcohol and caffeine (to rest their liver) until they are fully recovered.. Over a period of months it is prudent to monitor liver function via LFTs to ensure that the body is healing appropriately.. While the following herbal and nutritional support are not necessarily for the treatment of hepatitis A, they can assist with maintaining and improving liver health.. Herbal and Nutritional Liver Support. St Marys Thistle is a well known liver tonic. The active constituent Silymarin protects the liver by strengthening the outer membranes of liver cells, preventing toxins from entering the cells. Silymarin also stimulates protein synthesis in liver cells, which helps to regenerate and repair the liver. Silymarin compounds are also strong antioxidants, and have been shown to reduce damage to liver cells.. Reishi Mushroom ...
Patient: My SGPT level was 108 and SGOT 36. I was advised the doctor to take Reheptin tabs for 15 days(twice each day) and Diacomb D3(once a day). I took the medicines and didnt take alcohol at all. I repeated the LFT yesterday and the report shows elevated levels as compared to before ( SGPT-128, SGOT-52). I was advised last year of fatty liver through an ultrasound report.. Doctor: Hello,Thank you for your medical query at AskTheDoctor.comI understand your concern.Since you have fatty liver, the liver enzymes continue to be deranged.Reheptin is useful, however you also need Silymarin syrup or capsules twice daily to reduce the impact on the liver.They are not very elevated, so the values will come back once you take Silymarin. Also, you will need to follow a bland diet mostly comprising of green leafy vegetables and fruits for the time being. Avoid any kind of meat, or spicy food, or junk food.Please get a prescription for Silymarin and continue for 2 weeks twice daily and let me know the ...
taxifolin. Medicinal uses. Uses supported by clinical data. Supportive treatment of acute or chronic hepatitis and cirrhosis induced by alcohol, drugs or toxins (21-34).. Uses described in pharmacopoeias and in traditional systems of medicine. Treatment of dyspeptic complaints and gallstones (7, 35).. Uses described in folk medicine, not supported by experimental or clinical data. Treatment of amenorrhoea, constipation, diabetes, hay fever, uterine haemorrhages and varicose veins (6).. Pharmacology. Most of the biochemical and pharmacological studies have been performed using a standardized silymarin preparation, or its major constituent, silybin.. Experimental pharmacology. Antioxidant activity. Silymarin and silybin have antioxidant activity in vitro: both react with oxygenfree radicals such as hydroxyl anions, phenoxy radicals and hypochlorous acid in various model systems such as human platelets, human fibroblasts, rat liver microsomes and mitochondria, and using enzymatically and ...
Premium grade flavonoid & bioflavonoid supplements from Natures Best UK. Discover the benefits of flavonoid antioxidant supplements!
Liporidex POS/T also has 1,000 mcg of resveratrol per serving.. If you like to drink red wine (which has plenty of health benefits), you may be familiar with this ingredient, because that drink has heaps of it.. Resveratrol is a flavonoid antioxidant which helps improve blood flow, boost cardiovascular health, reduce oxidative stress, decrease muscle wasting, and ward off free radicals. We rarely stumble upon a post-workout which has resveratrol. In fact, Liporidex POS/T is the only one weve seen so far.. Kudos to the manufacturer for taking the road less traveled. For the consumers part, its like he or she drinks a cardiologist-approved-glass-of-red-wine every day.. On the other hand, Liporidex POS/Ts 4:1:1 BCAA ratio features three grams of leucine and 750 milligrams each of isoleucine and valine per serving. We love the three grams of leucine per serving. Really.. Leucine is predominantly responsible for the synthetic impact on muscle protein, per the manufacturers official ...
An extract (silymarin) from the plant Silybum marianum (milk thistle) was shown to increase circulating concentrations of prolactin in cycling rats. A dose-response study was undertaken to determine if silymarin does have hyperprolactinemic properties in cycling swine. Forty-four weaned sows were allotted to four groups receiving 0, 1, 2 or 4 g d1 of silymarin over a period of 8 d. Blood samples were obtained on days 1 (first day of treatment starting 24 to 48 h after the onset of the standing estrus), 2, 3, and 9. Prolactin, progesterone, estradiol-17p and leptin concentrations were determined. Silymarin did not increase prolactin concentrations at any of the doses studied, nor did it affect concentrations of the other hormones (P , 0.1).. ...
A study published recently in Phytotherapy Research (DOI: 10.1002/ptr.1988) demonstrated that the extract from the seeds of Milk Thistle, Silybum marianum (silymarin) may help in reducing blood sugar among diabetes patients.. The data came from a randomized double-blind clinical trial involving 51 people who had had type II diabetes for at least 2 years. One group of 25 patients received 200 mg of silymarin three times a day for 4 months, while the remaining 26 received a placebo treatment. All of the patients continued to use conventional oral hypoglycaemic treatment during the trial.. At the end of the trial, the treatment group showed a significantly reduced fasting blood glucose levels and a reduction in glycosylated haemoglobin.. Silymarin extracts mechanism of action, however, remains unknown. It may be attributed to the antioxidants called flavolignans. To verify these data, large multi-center studies will have to be conducted, according to the researchers.. ...
NOW Silymarin Milk Thistle Extract 150 mg - 60 Veg Capsules Milk Thistle Extract With Turmeric A Dietary Supplement Vegetarian/Vegan Silymarin (Silybum marianum), also known as Milk Thistle, has been used by traditional herbalists for centuries. Scientific studies have indicated that constituents in Silymarin may help to support healthy liver function. This vegetarian formula also includes Turmeric for additional support. Suggested Usage: Take 2 capsules 1 to 3 times daily with food. Supplement Facts Serving Size: 2 Veg Capsules Servings Per Container: 60 Amount Per Serving % Daily Value* * Percent Daily Values are based on 2,000 calorie diet. + Daily Value not established. Calories 5 Total Carbohydrate 1 g |1%* Milk Thistle Extract (Silybum marianum) (Standardized to 80% Silymarin Flavonoids) (Fruit and Seeds) 300 mg + Turmeric (Curcuma longa) (Root) 700 mg + Other Ingredients: Cellulose (capsule), Rice Flour and Magnesium
NOW Silymarin Milk Thistle Extract 150 mg - 60 Veg Capsules Milk Thistle Extract With Turmeric A Dietary Supplement Vegetarian/Vegan Silymarin (Silybum marianum), also known as Milk Thistle, has been used by traditional herbalists for centuries. Scientific studies have indicated that constituents in Silymarin may help to support healthy liver function. This vegetarian formula also includes Turmeric for additional support. Suggested Usage: Take 2 capsules 1 to 3 times daily with food. Supplement Facts Serving Size: 2 Veg Capsules Servings Per Container: 60 Amount Per Serving % Daily Value* * Percent Daily Values are based on 2,000 calorie diet. + Daily Value not established. Calories 5 Total Carbohydrate 1 g |1%* Milk Thistle Extract (Silybum marianum) (Standardized to 80% Silymarin Flavonoids) (Fruit and Seeds) 300 mg + Turmeric (Curcuma longa) (Root) 700 mg + Other Ingredients: Cellulose (capsule), Rice Flour and Magnesium
Title:Silybum marianum seeds oil attenuates CCl4-induced hepatic fibrosis via regulation of inflammatory response and oxidative stress. VOLUME: 14 ISSUE: 3. Author(s):Qiang Zhang, Fangxue Xu, Yujuan Li, Mengmeng Zheng, Xiaozhi Xi and Chunchao Han*. Affiliation:School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355. Keywords:Carbon tetrachloride, inflammatory response, liver fibrosis, oxidative stress, Silybum marianum seeds oil, wistar rats.. Abstract:Background: Liver fibrosis is a serious health problem worldwide. Literature sources ...
Import Data And Price Of Milk Thistle 80 Silymarin , www.eximpulse.com Eximpulse Services will provide you the latest and relevant market intelligence reports of Milk Thistle 80 Silymarin Import Data. You can find live data of maximum number of ports of India which is based on updated shipment data of Indian Customs. Only previous two days data will be seen on website. You can use this Milk Thistle 80 Silymarin import data for multiple kinds of analysis; lets say Import price, Quantity, market scenarios, Price trends, Duty optimization and many more. You can go through some of the sample shipment records for Milk Thistle 80 Silymarin import data mentioned above. Here on Eximpulse Services you will get all kind of free sample as well as detailed reports of Export/ Import data as per your requirement. To get in touch for any kind of enquiry related to free sample or detailed report contact on +91-120-408-4957, +91-120-408-4958,+91-120-428-4019.. Data post 2012 as per Notification No.18/2012 - ...
Milk thistle is an extremely helpful herb for pets. The scientific name for Milk Thistle is Silybum marianum. (You want to be sure the milk thistle supplement you select is labeled with this technical name.) The parts of the milk thistle plant that contain the therapeutic constituents are the fruit, shells, seeds, and leaves. (You want to be sure that the supplement you use contains these, and only these plant parts.). Milk thistle is known to be hepatoprotective. That means that this amazing herb can protect the liver from toxic damage from medications and chemicals as well as damage from viruses and bacteria. A great use for milk thistle is to give it for a week after using medications such as flea/tick/heartworm medications. The herb can stop the damage such drugs may cause.. Milk thistle is also considered to be a cholagogue. A colagogue is a substance that helps the gallbladder contract and empty. Think of using this herb for the treatment of gallstone sludge that can sometimes gum up the ...
H E R B A L ~ M O N O G R A P H {Milk thistle ~ Silybum marianum} Taste // Pungent & Bitter Temperature // Warm Effective Qualities // Drying, decongesting, restoring & dissolving . Milk thistle is the number one plant we think of when it comes to treating the liver, and it definitely deserves this reputation!
The Mediterranean plant |i|Silybum marianum|/i| L., commonly known as milk thistle, has been used for centuries to treat liver disorders. The flavonolignan silibinin represents a natural antioxidant and the main bioactive ingredient of silymarin (silybin), a standard extract of its seeds. Mitochondrial dysfunction and the associated generation of reactive oxygen/nitrogen species (ROS/RNS) are involved in the development of chronic liver and age-related neurodegenerative diseases. Silibinin A (SIL A) is one of two diastereomers found in silymarin and was used to evaluate the effects of silymarin on mitochondrial parameters including mitochondrial membrane potential and ATP production with and without sodium nitroprusside- (SNP-) induced nitrosative stress, oxidative phosphorylation, and citrate synthase activity in HepG2 and PC12 cells. Both cell lines were influenced by SIL A, but at different concentrations. SIL A significantly weakened nitrosative stress in both cell lines. Low concentrations not only
The Mediterranean plant |i|Silybum marianum|/i| L., commonly known as milk thistle, has been used for centuries to treat liver disorders. The flavonolignan silibinin represents a natural antioxidant and the main bioactive ingredient of silymarin (silybin), a standard extract of its seeds. Mitochondrial dysfunction and the associated generation of reactive oxygen/nitrogen species (ROS/RNS) are involved in the development of chronic liver and age-related neurodegenerative diseases. Silibinin A (SIL A) is one of two diastereomers found in silymarin and was used to evaluate the effects of silymarin on mitochondrial parameters including mitochondrial membrane potential and ATP production with and without sodium nitroprusside- (SNP-) induced nitrosative stress, oxidative phosphorylation, and citrate synthase activity in HepG2 and PC12 cells. Both cell lines were influenced by SIL A, but at different concentrations. SIL A significantly weakened nitrosative stress in both cell lines. Low concentrations not only
21 Sonnenbichler J, Scalera F, Sonnenbichler I, et al. ADD TO CART *USA delivery only *Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease … That is to say, it helps take some of that heavy load off the kidney. Only a few conventional medications are available for this condition. They seem to be producing the same purifying benefits as they do with humans. Milk thistle … Silymarin - an extract from the milk thistle plant. Milk thistle comes both as pills and a liquid form. Use Milk Thistle supplements. For over 2,000 years, milk thistle has been used to cleanse and detox the kidneys, liver, and spleen, or as a natural treatment for liver and gallbladder disease [2]. Silymarin is an ingredient in milky thistle that works miracles with respect to the protection of the kidneys… Cancer is a Cellular … By lowering LDL bad cholesterol levels, milk thistle may lower the chance of developing heart ...
APG IV Classification: Domain: Eukaryota • (unranked): Archaeplastida • Regnum: Plantae • Cladus: angiosperms • Cladus: eudicots • Cladus: core eudicots • Cladus: superasterids • Cladus: asterids • Cladus: euasterids II • Ordo: Asterales • Familia: Asteraceae • Subfamilia: Carduoideae • Tribus: Cardueae • Genus: Silybum • Species: Silybum marianum (L.) Gaertn., 1791 ...
Silibinin (INN), also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin, and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the liver, and there is some clinical evidence for the use of silibinin as a supportive element in alcoholic and child grade A liver cirrhosis. Poor water solubility and bioavailability of silymarin led to the development of enhanced formulations. Silipide (trade name Siliphos), a complex of silymarin and phosphatidylcholine (lecithin), is about 10 times more bioavailable than silymarin. An earlier study had concluded Siliphos to have 4.6 fold higher bioavailability.[unreliable medical ...
Milk Thistle Extract Specifications: Silymarin 80% UV (Silybin & Isosilybin 30%) Silymarin 80% HPLC (Silybin & Isosilybin 40%) Silymarin70% UV (Extracted by Ethanol) .....
The milk thistle plant commonly grows from 2 to 7 feet in height, with spiny leaves and reddish-purple, thistle-shaped flowers. It has also been called wild artichoke, holy thistle, and Mary thistle. Native to Europe, milk thistle has a long history of use as both a food and a medicine. At the turn of the twentieth century, English gardeners grew milk thistle to use its leaves like lettuce (after cutting off the spines), the stalks like asparagus, the roasted seeds like coffee, and the roots (soaked overnight) like oyster plant. The seeds and leaves of milk thistle were used for medicinal purposes as well, such as treating jaundice and increasing breast milk production. German researchers in the 1960s were sufficiently impressed with the history and clinical effectiveness of milk thistle to begin examining it for active constituents. In 1986, Germanys Commission E approved an oral extract of milk thistle as a treatment for liver disease. However, the evidence that it really works remains incomplete
Save 34% Jarrow Formulas - Milk Thistle Extract 150 mg 200 Capsules Milk Thistle Extract 150 mg Standardized Silymarin Extract 30:1 Supports Liver Function* Gluten Free Non-GMO Jarrow Formulas® Milk Thistle (Silybum marianum) 30:1 extract is standardized to contain 80% total Milk Thistle seed flavonoids, including the important Silymarin fractions isosilybinins A and B, silybinins A and B, silychristin and silydianin. This particular group of flavonoids, collectively known as Silymarin, supports liver function by raising protective glutathione levels.* Suitable for Vegetarians/Vegans. Vegetarian Capsules.
Possibly native near the coast of southeast England, it has been widely introduced outside its natural range, for example into North America, Iran, Australia and New Zealand where it is considered an invasive weed. Cultivated fields for the production of raw material for the pharmaceutical industry exist on a larger scale in Austria (Waldviertel region), Germany, Hungary, Poland, China and Argentina. In Europe it is sown yearly in March-April. The harvest in two steps (cutting and threshing) takes place in August, about 2-3 weeks after the flowering.[citation needed]. Exkursionsflora Fuer Kreta by Jahn & Schoenfelder (1995, page 326) states that the distribution is mediterranean-near east. They quote it as a native plant of Crete, Greece. Milk thistle (Silybum marianum) is a thorny plant presenting decorative leaves with a white pattern of veins and purple flower heads. The plant originates from mountains of the Mediterranean region, where it forms scrub on a rocky base. The plant is sometimes ...
Being a member of a family called Silybum and owing a biological name of Silybum Marianam, it is milk thistle that we are talking about. The plant is usually seen bearing pink to purple flowers. The plant of milk thistle can grow up to a height of 30 to 200 cm that bears somewhat hairy fruits. Benefits of Milk Thistle Liver cirrhosis: Liver cirrhosis is mainly a disease of the liver in which a person may experience symptoms such as nausea, vomiting, may also lose their appetite. It is the inflammation of the liver which causes liver cirrhosis. Milk thistle is one such thing that can treat liver cirrhosis easily. The natural ingredient called silymarin acts like magic. Hepatitis and other problems: One of the multiple uses of milk thistle has this one also in list which is its curing properties. Milk thistle can easily cure chronic problems such as hepatitis, autoimmune diseases and alcohol abuse. Milk thistle can also cure a damaged liver by some toxins that are present in the air especially in the air
Silybum marianum is a medicinal plant belonging to Asteraceae family. The magnetic field is an abiotic stress and is used for the growth and secondary meta ...
ماریتیغال (Silybum marianum L.) گیاهی است یک‌ساله، از خانواده گل ستاره‌ای‌ها که خاک‌های سبک و حاصلخیز را ترجیح می‌دهد. مهمترین ترکیبی که از دانه‌های این گیاه استخراج می‌شود سیلی‌مارین نام دارد که در درمان امراض کبدی، هپاتیت، سیروز کبدی و پیشگیری از سرطان کبد کاربرد دارد. در سیستم‌های کشاورزی متداول هدف استفاده از کودهای مختلف و تلفیق آنها، بدست آوردن بیشترین عملکرد دانه و کیفیت مواد مؤثره است. به‌منظور بررسی تأثیر کودهای مختلف و تلفیق آنها بر برخی خصوصیات کمّی و کیفی ماریتیغال، در سال زراعی 1393-1392 طرح کرت‌های خرد شده در پایه طرح بلوک‌های کامل تصادفی با سه
Help Your Liver Cleanse Your Body of Toxins With Potent Milk Thistle Helps ensure healthy liver and prostate function Your liver is the organ responsible for detoxing your body of the nearly 900 chemicals a day it encounters! Silymarin, a compound found in milk thistle, has long been used to support liver health. 60 vegetarian capsules Powerful Antioxidant and Prostate Health Support Milk Thistle Extract has long been used as both a potent antioxidant and a way to support healthy liver function. Recent extraction technology has made it possible to isolate the silymarin constituents isosilybin A and B as well as silibinins to benefit from their antioxidant support. This triple, standardized Milk Thistle Extract formula offers broad-spectrum support for healthy liver function and also supports prostate health. FAQs How does this formula differ from commercial silymarin supplements? It is the first milk thistle extract to contain standardized concentrations of isosilybin A and B as well as ...
Save 33% Lindberg - Milk Thistle Extract 175 mg 60 Capsules Milk Thistle Extract 175 mg Silybum marianum Standardized to 80% Silymarin Promotes Normal Liver Function* Milk Thistle Extract supports normal liver function. Silymarin, the active flavonoid complex, includes the subcomponents silychristin, silydianin, silybin A and B and isosilybin A and B. These compounds help exert a protective effect against substances that may be potentially harmful to the liver.* Vegetarian Capsules.
PURE ACTIVE INGREDIENT: Silymarin is considered one of the healthiest and most beneficial supplement and is renowned for its numerous health and wellness benefits. The vegetarian supplement provides 400mg of Silymarin Milk Thistle extract standardized to 80% Silymarin without any additives. FEATURES POWERFUL ANTI-OXIDA
Plant Extract Silymarin Milk Thistle Extract Products Made In China, China Trading Company. ~ Product name Milk thistle extract Latin Name Silybum marianum CAS no. 65666-07-1 Molecular Formula: C25H22O10 Molecular Weight: 482.44 Appearance Light sand yellow fine
Milk thistle is an extremely helpful herb for pets. The scientific name for Milk Thistle is Silybum marianum. (You want to be sure the milk thistle supplement you select is labeled with this technical name.) The parts of the milk thistle plant that contain the therapeutic constituents are the fruit, shells, seeds, and leaves. (You want to be sure that the supplement you use contains these, and only these plant parts.). Milk thistle is known to be hepatoprotective. That means that this amazing herb can protect the liver from toxic damage from medications and chemicals as well as damage from viruses and bacteria. A great use for milk thistle is to give it for a week after using medications such as flea/tick/heartworm medications. The herb can stop the damage such drugs may cause.. Milk thistle is also considered to be a cholagogue. A colagogue is a substance that helps the gallbladder contract and empty. Think of using this herb for the treatment of gallstone sludge that can sometimes gum up the ...
Page 1 of 4 - The Official Milk Thistle / Silymarin Thread - posted in Supplements: As a mechanism to distract myself from my studies, I did a little digging into our heretofore lightly discussed friend, milk thistle (active constituent blend: silymarin, most studied single constituent: silibinin). WOW. Theres been an explosion of research on this herb over the past decade. It seems to protect against just about any toxin you can think of, partly by upregulating endogenous antioxidant...
Since the evolution of mankind, humans are experimenting, examining and bringing to use as many as extracts and nutrients which are naturally grown by the plants as well as animals. Time and ages have now proven that natural enzymes work better and longer than any of their synthetic substitutes.. Milk Thistle, a plant commonly found in Mediterranean region is known for its ability to heal and prevent various liver diseases and cholesterol levels. The plant is now grown worldwide for its therapeutic uses. The plant is also known by the names Scotch Thistle, Mediterranean Milk Thistle, Blessed Milk Thistle, Mary Thistle.. What is Milk Thistle and what makes it the source of rich nutrients?. Milk Thistle plant grows in a conical shape with wide shoot at the bottom and a tapering shoot bearing purple flower/fruit. The leaves represent milky white veins and the name milk due to a white fluid that oozes out when the leaves are plucked. Milk Thistle or Silybum Marianum (scientific name) is a powerhouse ...
Milk Thistle or also known as Saint Marys thistle, blessed milk thistle, Mediterranean milk thistle, and Scotch thistle, belongs to the annual plant family of Asteraceae. The milk thistle plant often has red or purple flowers along with shiny but pale green leaves that have white veins. Experts believe that the milk ... Read more
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Order Pharmgrade Liv Clean Liver Detox With N- Acetyl Cysteine ( Nac ) & Silymarin Milk Thistle - 60 Tablets online & get upto 60% OFF on PharmEasy. Check out Pharmgrade Liv Clean Liver Detox With N- Acetyl Cysteine ( Nac ) & Silymarin Milk Thistle - 60 Tablets benefits and specifications. Also, get doorstep delivery PAN India.
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Summary: The healing power of silymarin has been known since ancient times (Theophrastus; 4th century BC). Silymarin is extracted from the milk thistle (Silybum marianum). Eighty percent of the plant extract are represented by Silibinin. Silymarin prevents liver damage and helps maintain normal liver function, possibly due to its antioxidant and membrane-stabilizing properties. Silymarin (Carsil -- Sopharma) increases intracellular gluthation and prevents the oxidative stress in hepatocytes by decreasing toxic superoxide radicals and nitric oxide production. This alleviates liver damage caused by hepatotoxins and prevents the progression of liver damage, including liver damage caused by alcohol consumption, into liver cirrhosis. Silymarin has been found to protect hepatocytes against a number of hepatotoxic drugs, including acetaminophen, dilantin, phenothiazine, halothan, and methotrexate. It can be used effectively as an antidote if applied in high doses (3400 mg/daily) up to the 48th hour ...
Milk thistle seed might protect liver cells from toxic chemicals and drugs. It also seems to have antioxidant and anti-inflammatory effects. Milk thistle plant extract might enhance the effects of estrogen. - WebMD
Now Foods Silymarin promotes overall liver health. It aids with liver detox, production of new liver cells, and help repair pre-existing damage to the liver cells. Silymarin is derived from the milk thistle herb.
Jarrow Formulas Milk Thistle (Silybum marianum) 30:1 concentrate is standardized to contain 80% total Milk Thistle seed flavonoids, including the important
Milk thistle is a member of the sunflower family native to a narrow area of the Mediterranean. It has since been naturalized throughout Europe and can commonly be found in Oregon and California where it is considered a common garden weed. Despite this unsavory reputation, milk thistle has quite a striking appearance, noted by the large pink or purple flower growing atop its solitary stem. The edible thistles were given the name silybum by Dioscorides, a Greek physician who served in the Roman Army over 1,900 years ago. The thistle with white mottling on its leaves became known as the milk thistle. In Catholic Germany, its usefulness was said to be second only to calling on Mother Mary, and the white mottling on the leaf is said to be the touch of the Virgin Marys milk, hence the species name marianum.. About Milk Thistle. The leaves of the milk thistle are edible and can be consumed as a potherb. Because the thorns must be snipped off before preparation as a food item, commercial ...
Milk thistle: (Silybum marianum). The medicinal utility of milk thistle flower seeds dates back to Pliny the Elder, a Roman naturalist, who described its use in treating liver disease. A hepatoprotective effect is imparted through the flavonoid active ingredient, silymarin. Silymarin alters hepatocyte cell membranes, thereby blocking the toxin-binding sites. Additionally, glutathione, which aids in the detoxification function of the liver, is increased by silymarin. Numerous changes have been detected in the liver of patients with psoriasis, including steatosis, periportal inflammation, fibrosis, necrosis, and cirrhosis. The value of silymarin in the treatment of psoriasis may be due to its ability to improve endotoxin removal by the liver, inhibit cAMP phosphodiesterase, and inhibit leukotriene synthesis. Abnormally high levels of cAMP and leukotrienes have been observed in patients with psoriasis and normalization of these levels may improve the condition (T. Steele, 2007 ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Milke thistle and its active ingredient silymarin have been used traditionally for liver disorders and science is now backing this use up. Silymarin is a potent antioxidant, an anti-inflammatory, and can protect liver cells from toxins and help them regenerate.
Shop for Silymarin Milk Thistle 1000 Mg Natural Whole Herb Softgels, Concentrated Herb By Natures Bounty - 50 Ea from Liver Health, Prostate. Browse other items form Milk Thistle Extract
Milk Thistle Extract specifications & features from suppliers/manufacturer Product Name:Milk Thistle ExtractLatin Name:Silybum Marianum(L.)Gaertn.Part Used:SeedsAppearance:Yellow Fine PowderSpecification:NLT80% SilymarinExtract Solvents: Acetone and EthanolIntroduction:Milk thistle, also known as the Marian, St. Marys, or

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So, do you know if the Chinese herbs had the 280 mg per day of Milk Thistle/Dandelion with the at least 70% silymarin? And ... I find myself hoping youll say, Oh, no not nearly enough! If you did 280mg with 70% silymarin for then youd instantly be HG- ... 2. I have found milk thistle (standardized to contain at least 70% - 80% silymarin) to be invaluable in preventing morning ... silymarin) is of great benefit to aid the livers functions. Recommened amount: 280 mg per day. Dandelion is a gentler liver ...
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  • In this study, the protective effect of silymarin (SN) against cardiotoxicity induced by ACR in mice was evaluated. (hindawi.com)
  • Protective effect of silymarin during coronary artery bypass grafting surgery. (greenmedinfo.com)
  • To investigate the effect of silymarin, derived from the milk thistle plant, Silybum marianum, in preventing and reversing the complications of chronic infection with hepatitis C virus and/or clearing hepatitis C infections. (clinicaltrials.gov)
  • The objective of this exploratory project is to assess the feasibility of investigating the effect of silymarin, derived from the milk thistle plant, Silybum marianum, in preventing and reversing the complications of chronic infection with HCV and/or clearing HCV infections, thereby generating preliminary results to serve as the basis of a more definitive study. (clinicaltrials.gov)
  • Indeed, the anti-oxidant and anti-inflammatory effect of silymarin is oriented towards the reduction of virus-related liver damages through inflammatory cascade softening and immune system modulation. (nih.gov)
  • It is important to point out that this effect of silymarin administration did not alter the glutathione redox state of the liver, as the GSH/GSSG ratio was not modified by the treatment. (chiro.org)
  • however, effect of silymarin on spontaneous HCC has not been studied. (aacrjournals.org)
  • The protective effect of silymarin was attributed to its antioxidant and free radicals scavenging properties. (digitalnaturopath.com)
  • Radioprotective effect of silymarin against radiation induced hepatotoxicity. (digitalnaturopath.com)
  • Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis carried out at two medical centers. (digitalnaturopath.com)
  • In this report, we investigated the effect of silymarin on NF-κB activation induced by various inflammatory agents. (jimmunol.org)
  • Short communication: Effect of silymarin (Silybum marianum) treatment on prolactin concentrations in cyclic sows, 93(2), 227-230. (gc.ca)
  • the aim of this study was to evaluate the effect of silymarin and the influence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant on the response to treatment in patients with NAFLD in a pilot study. (isciii.es)
  • In this study, we investigated the anticarcinogenic effect of silymarin and associated molecular mechanisms, using human breast carcinoma cells MDA-MB 468. (aacrjournals.org)
  • RESULTS: The clinical evidence ofa therapeutic effect of silymarin in toxic liver diseases is scarce. (uzh.ch)
  • The objective of the present study was to evaluate the hematobiochemical effects tempted by ochratoxin A (OTA) in White Leghorn (WL) cockerels and to evaluate the effect of silymarin (SL), vitamin E (VE) and their combination against OTA persuaded pathological alterations in cockerels. (fao.org)
  • Formulated especially for oily and blemish-prone skin, this breakthrough formula combines 0.5% silymarin (milk thistle extract), 15% l-ascorbic acid, 0.5% ferulic acid and 0.5% salicylic acid to deliver advanced environmental protection, as well as reduce oiliness, refine skin texture, and visibly improve skin clarity and fine lines. (dermstore.com)
  • Silymarin, an extract of milk thistle commonly used to treat chronic liver disease by millions of people around the World, does not offer significant improvements for patients, according to a new study conducted by a nationwide group of researchers including faculty at the Perelman School of Medicine at the University of Pennsylvania. (news-medical.net)
  • Silymarin is a standardised extract from the seeds and fruits of the milk thistle Silybum marianum and contains, as its main constituents, the flavonolignans silybin, isosilybin, silydianin and silychristin. (springer.com)
  • Silymarin is a standardized extract from the dried seeds of the milk thistle ( Silybum marianum L. Gaertn. (hindawi.com)
  • The milk thistle extract used in traditional herbal medicine comes from the seeds and typically contains four to six percent silymarin. (xtend-life.com)
  • Modern milk thistle extract is more highly refined and is usually standardized to about 80 percent silymarin, with various fatty acids comprising the remaining portion. (xtend-life.com)
  • The active compound in milk thistle is Silymarin Milk Thistle Liver Detox uses a standardized extract that yields 80% Silymarin. (puritan.com)
  • The extract of the seed-like fruit (achene) of the milk thistle plant ( Silybum marianum ) is known as silymarin. (diagnose-me.com)
  • An average dose is 200mg of an extract standardized for 70-80% silymarin. (diagnose-me.com)
  • Source Naturals Europure Silymarin contains a unique high quality European milk thistle seed extract. (vitasprings.com)
  • The milk thistle used for this silymarin extract is grown and processed according to strict European Union guidelines to meet our high standards of quality. (vitasprings.com)
  • Milk thistle extract, known scientifically as silymarin, is a member of the daisy family. (thewayup.com)
  • Now Foods Silymarin provides 350 mg of Milk Thistle Extract in each serving. (evitamins.com)
  • Silymarin is the extract of Silybum marianum , or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. (nih.gov)
  • Pure Encapsulations Silymarin 250 mg 120 vcaps is a milk thistle extract that nutritionally supports liver function. (integrativepsychiatry.net)
  • Silymarin is a highly concentrated milk thistle extract that supports healthy liver functioning through a number of mechanisms. (integrativepsychiatry.net)
  • This milk thistle extract is standardized to 80% silymarin. (nutritionexpress.com)
  • 1. Silymarin extract is widely used in medicine, health products, food and cosmetics. (alibaba.com)
  • Silymarin is a milk thistle extract that is designed to nutritionally support liver function. (bayho.com)
  • Silymarin Plus TM combines Milk Thistle extract, standardized for 80% silymarin, with six other supportive herbs and nutrients including Dandelion root and Beet root. (vitaglo.com)
  • Silymarin Plus TM contains 525 mg of Milk Thistle seed extract, standardized for 80% {420 mg} Silymarin per daily dose. (vitaglo.com)
  • Certified European Milk Thistle is the first milk thistle extract to contain standardized, premium-quality potencies of silymarin, silibinins, isosilybin A and isosilybin B, providing the full spectrum of milk thistle compounds that promote a healthy liver and prostate. (makemeheal.com)
  • NOW® Extra Strength Silymarin has three times the Milk Thistle Extract (450 mg per softgel) as in our regular strength product (150 mg per capsule). (vitanetonline.com)
  • Silymarin / Milk Thistle Capsules from Douglas Labs provide 150 mg of Milk Thistle extract. (ovitaminpro.com)
  • Silymarin/Milk Thistle Extract has been extensively researched in Europe for over 30 years. (vitaglo.com)
  • A study published recently in Phytotherapy Research (DOI: 10.1002/ptr.1988) demonstrated that the extract from the seeds of Milk Thistle, Silybum marianum (silymarin) may help in reducing blood sugar among diabetes patients. (biotech-weblog.com)
  • Silymarin is the major active compound from milk thistle extract ( Silybum marianum ) and offers powerful antioxidant support for the liver. (lifeextension.com)
  • Metabolic Maintenance's Silymarin capsules provide 300 mg of silymarin from standardized milk thistle (silybum marianum) extract. (swansonvitamins.com)
  • An extract (silymarin) from the plant Silybum marianum (milk thistle) was shown to increase circulating concentrations of prolactin in cycling rats. (gc.ca)
  • DESCRIPTION Silymarin/Milk Thistle capsules, provided by Douglas Laboratories, contain 150 mg of milk thistle extract, standardized to contain a minimum of 80% of the flavonoid silymarin (120mg). (supervits.com)
  • Silymarin, the collective name for an extract from the milk thistle [ Silybum marianum (L.) Gaertneri], is a naturally occurring polyphenolic flavonoid antioxidant. (aacrjournals.org)
  • BACKGROUND: The potential benefit of silymarin (special extract from the fruits of Silybum marianum) in the treatment of liver diseases remains a controversial issue. (uzh.ch)
  • Silymarin is an extract derived from the seed of the milk thistle plant with potent liver detoxifying properties and famous liver tonic. (tasmanhealth.co.nz)
  • NOW ® Double Strength Silymarin has twice the milk thistle extract (300 mg per capsule) as in our regular strength product (150 mg per capsule). (fruitfulyield.com)
  • Many studies have been conducted on in vitro effects of silymarin on different types of cells, which reveal anti-cancer and antioxidant effects of this plant extract [ 9 - 11 ]. (alliedacademies.org)
  • New products raw material Milk Thistle P.E. powder Silymarin Extract 80% Silybin uses imported high-quality stainless steel materials, exquisite workmanship, sturdiness and durability. (digit-life.com)
  • Background and Aims: Silymarin, an extract from the seeds of the milk thistle plant Silybum marianum, has been used for centuries for the treatment of chronic liver diseases. (uncg.edu)
  • The potential benefit of silymarin (extracted from the seeds of Silybum marianum or milk thistle) in the treatment of liver diseases remains a controversial issue. (springer.com)
  • Silymarin, which derived from the milk thistle plant (silybum marianum), has been used for centuries as a natural remedy for diseases of the liver and biliary tract. (greenmedinfo.com)
  • Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum . (dovepress.com)
  • Silymarin (Silybum marianum)‚ also known as Milk Thistle‚ is an herb that is well-documented in early traditional herbal medicine. (pureformulas.com)
  • Silymarin (Silybum marianum), also known as Milk Thistle, has been used by traditional herbalists for centuries. (totaldiscountvitamins.com)
  • Silymarin is a group of lignan flavonoids unique to Milk Thistle (Silybum marianum) that research has shown helps protect the liver from free radicals, supports normal liver function and is a hepatoprotectant that can help protect the liver from the damaging effects of toxins. (vitaglo.com)
  • Silymarin, derived from the milk thistle plant Silybum marianum (L.) Gaertn] is a natural polyphenolic flavonoid. (springer.com)
  • The silymarin compound comes from milk thistle ( Silybum marianum ). (lifeextension.com)
  • Silymarin is a polyphenolic flavonoid derived from milk thistle ( Silybum marianum ) that has anti-inflammatory, cytoprotective, and anticarcinogenic effects. (jimmunol.org)
  • One of these, silymarin, is a polyphenolic flavanoid isolated from the fruits and seeds of the milk thistle (also called artichoke) (Silybum marianum) (for references, see Ref. 2 ). (jimmunol.org)
  • Silymarin complex, particularly the silybum component, appears to help support the liver through antioxidant activity and stabilization of the cell membranes. (swansonvitamins.com)
  • The effect of some environmental factors on the quantity and quality of Silymarin and seed oil of Silybum marianum L. (magiran.com)
  • The medical part of milk thistle (silybum marianum), with the therapeutic silymarin, is beneficial in reducing blood cholesterol. (alliedacademies.org)
  • Finally, some initial laboratory studies have shown that silymarin and some other active constituents of milk thistle have anti-cancer activity. (ei-resource.org)
  • Studies in patients with liver disease have shown that silymarin increases Superoxide dismutase (SOD) activity of lymphocytes and erythrocytes, as well as the expression of SOD in lymphocytes. (springer.com)
  • It was also shown that silymarin had no effects on body weight, food intake, and liver transaminase. (greenmedinfo.com)
  • Studies have shown that silymarin acts as a free radical scavenger to support the body's own antioxidant defense system. (vitasprings.com)
  • Studies have shown that silymarin antioxidant effects protect liver cells [ 7 ]. (alliedacademies.org)
  • Animal and human studies have shown that silymarin even has some ability to reverse the deadly effects of the "death cap" mushroom - the lethal Amanita phalloides (responsible for 90 percent of all mushroom poisonings). (naturalhealth365.com)
  • Be the First to Review Milk Thistle (Silymarin) Standardized Extact Capsules! (nutritionaltree.com)
  • Therefore, we sought to assess and compare the pharmacokinetic properties and bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules and conventional silymarin tablets in healthy Mexican volunteers. (springer.com)
  • Silymarin has potent antioxidant and anti-inflammatory properties and helps to protect liver cells from damage that would normally result from toxins such as alcohol. (ei-resource.org)
  • Participants will be randomly assigned to receive silymarin or a vitamin supplement (below antioxidant levels). (clinicaltrials.gov)
  • The antioxidant properties of silymarin (a mixture of at least 4 closely related flavonolignans, 60 to 70% of which is a mixture of 2 diastereomers of silybin) have been demonstrated in vitro and in animal and human studies. (springer.com)
  • Silymarin is considered a liver protectant, a choleretic (moving bile ), and a liver-specific antioxidant . (diagnose-me.com)
  • Studies since the 1930s, conducted mainly in Germany, researched that the silymarin found in the herb works to stabilize liver cell membranes and act as an antioxidant to protect liver cells from free radical damage . (diagnose-me.com)
  • In this respect, silymarin would share with (+)-cyanidanol-3, an antioxidant mechanism of action acting as free radical scavengers. (chiro.org)
  • Silymarin also provides antioxidant protection and stimulates protein synthesis on a cellular level. (bayho.com)
  • Silymarin prevents the depletion of the intracellular antioxidant, glutathione, within liver cells, thereby enhancing detoxification and protecting cells from free radical activity. (orthomolecularproducts.com)
  • Silymarin been found to increase a powerful antioxidant called glutathione (crucial for liver detoxification), and may also help to regenerate liver cells. (bodykind.com)
  • In in vitro studies, silymarin demonstrated antioxidant activity and the ability to inhibit lipid peroxidation of cellular membranes. (vitaglo.com)
  • Life Extension's Silymarin supplement contains high-quality silymarin, a compound extracted from milk thistle to support healthy liver function, provide antioxidant support and more. (lifeextension.com)
  • Various studies indicate that silymarin exhibits strong antioxidant activity ( 3 , 4 , 5 ), increases cellular glutathione content ( 6 ), and induces superoxide dismutase (SOD) 3 ( 4 ). (jimmunol.org)
  • Because silymarin has been described to be an antioxidant with anti-inflammatory, cytoprotective, and anticarcinogenic effects, we tested the hypothesis that these effects are mediated through its modulation of activation of NF-κB, members of the MAPK, and caspase-mediated apoptosis. (jimmunol.org)
  • In chronic liver diseases caused by oxidative stress (alcoholic and non-alcoholic fatty liver diseases, drug- and chemical-induced hepatic toxicity), the antioxidant medicines such as silymarin can have beneficial effect. (wonderlabs.com)
  • Silymarin further protects the liver as an important component of the liver's antioxidant defense. (supervits.com)
  • Recently, we showed that silymarin, a flavonoid antioxidant isolated from milk thistle, possesses exceptionally high to complete protective effects against experimentally induced tumor-igenesis. (aacrjournals.org)
  • Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2′-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats. (aacrjournals.org)
  • Silymarin, a flavonoid antioxidant isolated from milk thistle, exerts exceptionally high to complete anticarcinogenic effects in tumorigenesis models of epithelial origin. (aacrjournals.org)
  • Given the importance of enhanced oxidative stress in the incidence of tissue damage by nanoparticles and the role of silymarin in reducing oxidative stress index, this study was conducted to evaluate the protective and antioxidant effects of silymarin on male rats treated with gold nanoparticles. (alliedacademies.org)
  • Scientists have learned that the most biologically active compounds in milk thistle are a group of flavonoids, silibinin, silidianin, and silicristin, collectively called silymarin. (ei-resource.org)
  • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. (dogcancerblog.com)
  • Studies were conducted in the sensitive and multidrug resistant human breast cancer cell lines MCF-7 and MDA435/LCC6 and examined the effects of the flavonoids biochanin A, morin, phloretin, and silymarin on daunomycin (DNM) accumulation and doxorubicin cytotoxicity. (aspetjournals.org)
  • Biochanin A and phloretin stimulated, whereas morin and silymarin inhibited P-gp ATPase activity, confirming that these flavonoids interact with P-gp. (aspetjournals.org)
  • This particular group of flavonoids, collectively known as Silymarin, support liver function by raising protective glutathione levels. (vitadigest.com)
  • The effects of silymarin on NF-κB activation were specific, as AP-1 activation was unaffected. (jimmunol.org)
  • Overall, the inhibition of activation of NF-κB and the kinases may provide in part the molecular basis for the anticarcinogenic and anti-inflammatory effects of silymarin, and its effects on caspases may explain its role in cytoprotection. (jimmunol.org)
  • Because silymarin exhibits anticarcinogenic, anti-inflammatory, and growth-modulatory effects, much as TNF does, we hypothesized that these effects of silymarin are mediated through suppression of NF-κB activation, the mediator of many of the TNF effects. (jimmunol.org)
  • The inhibitory effects of silymarin on cell growth and proliferation were associated with a G1 arrest in cell cycle progression concomitant with an induction of up to 19-fold in the protein expression of cyclin-dependent kinase (CDK) inhibitor Cip1/p21. (aacrjournals.org)
  • ABSTRACT To investigate the effects of silymarin on follicular development, we enrolled 40 healthy women undergoing in vitro fertilization (IVF) due to male factor infertility in this trial. (who.int)
  • The major component of silymarin is silybin (which is a mixture of 2 diastereomers), which constitutes between 60 and 70% of the drug and is the major active component. (springer.com)
  • Silymarin is actually a combination of the flavonolignans silybin, silydianin, and silychristin. (diagnose-me.com)
  • Furthermore, silymarin/silybin use has important biological effects in non-alcoholic fatty liver disease. (nih.gov)
  • Therefore, the aim of this review is to examine scientific studies concerning the effects derived from silymarin/silybin use in chronic liver diseases, cirrhosis and hepatocellular carcinoma. (nih.gov)
  • Seeds of the dried milk thistle flower are rich in silymarin, a bioflavonoid complex of three flavonolignins: silybin, silydianin, and silychristin. (supervits.com)
  • Several studies have demonstrated that many natural products and herbal medicines have activity against liver fibrosis, and extracts of milk thistle such as silymarin and silybin are the natural compounds most commonly prescribed for liver diseases. (springer.com)
  • Fasting participants received either 45 mg silybin-phosphatidylcholine complex or 70 mg silymarin to assess which formulation provided better bioavailability of silybin. (springer.com)
  • In a double-blind, randomized, placebo-controlled multicenter trial involving 179 participants and published in Free Radical Biology and Medicine , patients with NAFLD were given silybin (a form of silymarin) daily for a year - while a similar group received placebo. (naturalhealth365.com)
  • Past research has highlighted the ability of silymarin and silybin to stop nonalcoholic fatty liver disease from progressing to nonalcoholic steatohepatitis (NASH), a more dangerous form of the condition that can lead to liver scarring, liver cancer , liver failure and death. (naturalhealth365.com)
  • The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. (hindawi.com)
  • The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µ g/mL for all strains. (hindawi.com)
  • Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line. (hindawi.com)
  • The active bioflavonoid complex in milk thistle, silymarin, and its sub-component silibinin, are powerful antioxidants in the liver and exert a protective detox effect against substances that may be potentially harmful to the liver. (nutritionexpress.com)
  • As a mechanism to distract myself from my studies, I did a little digging into our heretofore lightly discussed friend, milk thistle (active constituent blend: silymarin, most studied single constituent: silibinin). (longecity.org)
  • silymarin is comprised of silibinin and its other stereoisomers, including isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. (rti.org)
  • Silymarin and silibinin (50-100 microg/ml) inhibited cell proliferation, induced cell death, and caused G1 and G2-M cell cycle arrest in a dose/time-dependent manner. (rti.org)
  • The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity. (rti.org)
  • Chk2-specific small interfering RNA largely attenuated the silymarin and silibinin-induced G2-M arrest. (rti.org)
  • These findings indicate that silymarin and silibinin modulate G1 phase cyclins-CDKs-CDKIs for G1 arrest, and the Chk2-Cdc25C-Cdc2/cyclin B1 pathway for G2-M arrest, together with an altered subcellular localization of critical cell cycle regulators. (rti.org)
  • Overall, we observed comparable effects for both silymarin and silibinin at equal concentrations by weight, suggesting that silibinin could be a major cell cycle-inhibitory component in silymarin. (rti.org)
  • However, other silibinin stereoisomers present in silymarin also contribute to its efficacy, and could be of interest for future investigation. (rti.org)
  • Silymarin and silibinin, which is the major active constituent of silymarin, can inhibit the growth of human prostate carcinoma LNCaP, PC-3, and DU145 cells in culture ( 15 - 17 ). (aacrjournals.org)
  • Moreover, silymarin and silibinin inhibit cell growth and induce apoptosis in rat prostate cancer cell lines ( 18 ). (aacrjournals.org)
  • METHODS: For this systematic review electronic databases identified 65 papers for the search terms silymarin, silibinin, silicristin or milk thistle and clinical trial. (uzh.ch)
  • Silymarin milk thistle , it is a kind of ingredients of silibinin, a plant that belongs to the sunflower family, has ancient origins in the Mediterranean. (digit-life.com)
  • The administration of silymarin to fed rats resulted in no changes in the basal lipid peroxidative rate of the liver. (chiro.org)
  • Administration of silymarin as oral or IV doses caused significant protection against liver damage. (digitalnaturopath.com)
  • According to open studies the long-term administration of silymarin significantly increased survival time of patients with alcohol induced liver cirrhosis. (wonderlabs.com)
  • The aim of the present study was to find a method to increase oral bioavailability of silymarin, that is to say, by the preparation of silymarin proliposome and to compare the pharmacokinetic characteristics and bioavailability after oral administration of silymarin proliposome and silymarin in beagle dogs. (ovid.com)
  • The concentrations of silymarin in plasma of beagle dogs and its pharmacokinetic behaviors after oral administration of silymarin liposome suspensions and silymarin were studied by RP-HPLC. (ovid.com)
  • Also, dietary administration of silymarin increased apoptotic index in prostatic adenocarcinoma by measuring immunohistochemically positive nuclei for ssDNA. (aacrjournals.org)
  • These data suggest that administration of silymarin in IVF patients concomitantly with gonadotropin results in reduction of granolusa cell apoptosis but does not have any effect in promotion of follicular development, oocyte retrieval or endometrial thickness. (who.int)
  • Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD. (nih.gov)
  • Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin. (dogcancerblog.com)
  • In addition to an optimal 80% stan-dardization of the main active compounds, silymarin flavonolignans, this formula is further standardized to three highly active isomers - silibinins and isosilybin A and B. (makemeheal.com)
  • 1-3 Silymarin, a mixture of flavonolignans extracted from the milk thistle, helps inhibit oxidative stress, which supports healthy liver function. (lifeextension.com)
  • Pure Encapsulations Silymarin (milk thistle) offers support for the liver, cells and colon. (ovitaminpro.com)
  • The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. (nih.gov)
  • Pharmacological studies indicate that silymarin is not toxic even at high doses ( 12 ). (jimmunol.org)
  • Our results indicate that silymarin exerts chemopreventive ability against chemically induced prostatic carcinogenesis through apoptosis induction and modification of cell proliferation. (aacrjournals.org)
  • The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as α-amanitin. (springer.com)
  • The mechanisms of action of silymarin involve different biochemical events, such as increasing the synthesis of ribosomal RNA (rRNA) species through stimulatio of polymerase I and rRNA transcription (thereby increasing the synthetic rate of structural and functional proteins), blockage of the uptake of toxins such as α-amanitin from Amanita phalloides (the deathcap mushroom), and protecting the cell membrane from osmotic stress and radical-induced damage. (springer.com)
  • Silymarin, derived from the milk thistle plant, has been used as a natural remedy for the treatment of a number of liver diseases as well as in the protection of the liver from potential toxins. (sigmaaldrich.com)
  • Milk Thistle contains antioxidants renowned for protecting the liver from toxins (including alcohol) called silymarin and silbyn. (bodykind.com)
  • By binding to the outer cell membrane, silymarin prevents harmful toxins from entering the cell. (supervits.com)
  • As a potent detoxicant, silymarin also inhibits the binding of toxins to cells. (naturalhealth365.com)
  • Silymarin is a flavonoid compound derived from milk thistle that supports liver function and enhances detoxification pathways. (orthomolecularproducts.com)
  • Silymarin nutritionally supports healthy liver function. (vitaglo.com)
  • These data show that even higher-than-normal doses of silymarin don't significantly reduce ALT levels for patients with HCV,' said Reddy, noting that the doses used in the trial were three and five times higher than the customary dose. (news-medical.net)
  • Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis. (greenmedinfo.com)
  • However, upon subanalysis, silymarin 420 mg/day had a significantly beneficial effect on patient survival rate (compared with patients receiving placebo) in 1 randomised, double-blind trial in patients with alcoholic cirrhosis. (springer.com)
  • Two studies showed that silymarin 420 mg/day significantly increased the SOD activity of lymphocytes and erythrocytes, as well as SOD expression in lymphocytes of patients with histologically proven micronodular cirrhosis. (springer.com)
  • In 2 further studies, silymarin 10 mg/L significantly increased SOD expression in lymphocytes from patients with liver cirrhosis. (springer.com)
  • Silymarin 420 mg/day has also been shown to significantly increase serum levels of glutathione and glutathione peroxidase and SOD activity of erythrocytes and lymphocytes compared with placebo in patients with chronic alcoholic liver disease. (springer.com)
  • Furthermore, silymarin 800 mg/day significantly reduced serum levels of malondialdehyde, the end-product of linoleic acid oxidation in cell membranes, in a double-blind, placebo-controlled trial involving 60 patients who had been taking psychotropic drugs for at least 5 years. (springer.com)
  • Silymarin significantly increased the hepatic content of both GSH and GSSG, thus enhancing by 32% the content of total GSH equivalents (GSH + 2GSSG) of the liver, when compared to control rats given CMC. (chiro.org)
  • Although silymarin did not affect HBx expression, intracellular reactive oxygen species levels were decreased, cell proliferation was stimulated, and hepatocyte ultrastructure was found to significantly recover. (aacrjournals.org)
  • Silymarin strongly prevents photocarcinogenesis, and significantly prevented melanin production. (springer.com)
  • Silymarin also blocked NF-κB activation induced by phorbol ester, LPS, okadaic acid, and ceramide, whereas H 2 O 2 -induced NF-κB activation was not significantly affected. (jimmunol.org)
  • Based on the results of studies using methods of molecular biology, silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. (wonderlabs.com)
  • Morin and silymarin significantly inhibited [ 3 H]azidopine photoaffinity labeling of P-gp, suggesting a direct interaction with P-gp substrate binding. (aspetjournals.org)
  • Silymarin treatment resulted in a significantly high to complete inhibition of both anchorage-dependent and anchorage-independent cell growth in a dose- and time-dependent manner. (aacrjournals.org)
  • Silymarin 80 from Metagenics is designed as a dietary supplement to support healthy liver function. (evitamins.com)
  • Studies abroad and in the U.S. have indicated that contituents in Silymarin may help to support healthy liver function. (pureformulas.com)
  • Scientific studies have indicated that constituents in Silymarin may help to support healthy liver function. (totaldiscountvitamins.com)
  • Silymarin, a flavonoid complex extracted from milk thistle seeds, is an important contributor to the support of healthy liver function. (vitaglo.com)
  • Our Silymarin is formulated with the same ingredients as clinical studies to help support healthy liver function. (lifeextension.com)
  • Silymarin Milk Thistle is optimized for fast absorption to support healthy liver function. (wonderlabs.com)
  • Silymarin has been shown to support and enhance normal, healthy liver function through three primary actions. (supervits.com)
  • Silymarin milk thistle herbal supplement concentrated herb soft gels to help and maintain healthy liver function. (myotcstore.com)
  • Primary efficacy data from 3 trials which examined the therapeutic potential of silymarin in patients with cirrhosis, and included patient survival as an endpoint, demonstrated that silymarin had no significant beneficial effect on patient mortality. (springer.com)
  • Although silymarin has low oral absorption, oral dosages of 420 mg/day have shown some therapeutic potential, with good tolerability, in the treatment of alcoholic cirrhosis. (springer.com)
  • Considering the therapeutic potential to liver disease, we tested efficacy of silymarin on hepatic steatosis with a high fat diet (HFD)-induced mouse model of non-alcoholic fatty liver disease (NAFLD), and investigated possible effects on lipid metabolic pathways. (greenmedinfo.com)
  • Our data indicated that silymarin has therapeutic effects on the early stages of liver damage, reversing fatty changes and recovering liver histopathology in a dose-dependent manner. (aacrjournals.org)
  • In recent years, silymarin has also been used in Asia as a therapeutic agent for liver diseases ( 6 ). (aacrjournals.org)
  • In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). (nih.gov)
  • It is hypothesized that silymarin will not lead to clearance of HCV infections but can prevent progression of liver disease in participants with chronic HCV hepatitis and, in some cases, reverse hepatic lesions that are already present, as well as improving the quality of life in individuals who use this dietary supplement. (clinicaltrials.gov)
  • Silymarin could attenuate hepatic steatosis in a mouse model of NAFLD through regulation of lipid metabolism and oxidative stress. (greenmedinfo.com)
  • In our study, silymarin could attenuate the hepatic steatosis, which was proved by both Oil Red O staining and hepatic triglyceride (TG) level determination. (greenmedinfo.com)
  • Taken together, silymarin could attenuate hepatic steatosis in a mouse model of NAFLD through regulation of lipid metabolism and oxidative stress, and benefit to the circulation system. (greenmedinfo.com)
  • The mechanism of silymarin-induced enhancement of hepatic glutathione content is currently under study in our laboratory. (chiro.org)
  • By inhibiting lipid peroxidation, silymarin protects against hepatic toxicity induced by a wide variety of agents ( 7 , 8 , 9 , 10 , 11 ). (jimmunol.org)
  • Silymarin has also been shown to increase patient serum levels of glutathione and glutathione peroxidase. (springer.com)
  • ii) Silymarin pretreatment exhibited a novel effect on the glutathione status of the liver cell, not observed in experiments using (+)-cyanidanol-3. (chiro.org)
  • Furthermore, silymarin enhances levels of glutathione and superoxide dismutase, two primary antioxidants in the liver. (supervits.com)
  • 1] [2] A preparation of silymarin complexed with phosphatidylcholine was reported to help sufferers of chronic viral hepatitis. (diagnose-me.com)
  • Methods: Freshly isolated PBMC and T cells from HCV-infected and uninfected subjects were tested in vitro for responses to nonspecific and antigenic stimulation in the presence and absence of a standardized preparation of silymarin (MK001). (uncg.edu)
  • Silymarin, the main bioflavonoid complex found in milk thistle seeds, has been used to support gallbladder and liver function and to promote healthy detoxification function. (orthomolecularproducts.com)
  • The main bioflavonoid complex found in milk thistle seeds, silymarin has been widespread in use for thousands of years to improve bile transport and support the liver, spleen and kidneys. (orthomolecularproducts.com)
  • All subject receive silymarin at dose of 420mg or placebo in three dose for 65 consecutive day, urine NGAL concentration will be measured. (knowcancer.com)
  • They underwent ovulation induction and on a random and blind basis, patients were assigned to receive silymarin (70 mg × 3/day) or placebo from the beginning of the induction cycle. (who.int)
  • The primary active constituent in milk thistle is silymarin. (xtend-life.com)
  • silymarin (the chemical constituent thought to be responsible for milk thistle's medical benefits) does not dissolve well in water, so the teas are very weak. (diagnose-me.com)
  • Among the compounds tested, a silymarin constituent called isosilybin B proved to be the most efficient in maintaining healthy cell division. (makemeheal.com)
  • Milk thistle - and its active constituent, silymarin - has excited interest among researchers because it has two properties that combine to make it a sort of "Holy Grail" of natural liver remedies. (naturalhealth365.com)
  • In this study, we assessed whether silymarin inhibits erbB1 activation and associated downstream events and modulates cell cycle regulatory proteins and progression, leading to growth inhibition of human prostate carcinoma DU145 cells. (aacrjournals.org)
  • Silymarin inhibits tumor promoter-caused induction of ornithine decarboxylase activity and mRNA expression in mouse epidermis ( 20 ). (aacrjournals.org)
  • Silymarin inhibits mRNA expression of endogenous tumor promoter tumor necrosis factor-α ( 21 ). (aacrjournals.org)
  • Furthermore, compared with INT-747, a potent and selective FXR agonist, silymarin could preserve plasmatic high-density lipoprotein cholesterol (HDL-C) to a higher level and low-density lipoprotein cholesterol (LDL-C) to a lower level, which benefited more to the circulation system. (greenmedinfo.com)
  • Due to its variety of functions, the Silymarin Forte formula makes a potent addition to any liver support and detoxification program. (orthomolecularproducts.com)
  • Besides its hepatoprotective principle, silymarin is a potent chemopreventive agent ( 13 , 14 , 15 ). (jimmunol.org)
  • Our results demonstrate that silymarin is a potent inhibitor of NF-κB activation. (jimmunol.org)
  • Silymarin has been shown to be a potent anticarcinogenic agent. (aacrjournals.org)
  • Silymarin acts as a potent anticarcinogenic agent against in vitro and in vivo carcinogenesis experiments ( 12 - 14 ). (aacrjournals.org)
  • This means that silymarin offers potent ammunition against metabolic syndrome - a linked cluster of unhealthy conditions that includes excess abdominal fat, elevated blood sugar levels, elevated blood pressure, elevated LDL cholesterol and high triglycerides. (naturalhealth365.com)
  • By all indications, silymarin is no more effective at treating hepatitis C related chronic liver disease, in those who failed standard therapy with interferon, than a placebo,' said K. Rajender Reddy, MD, professor of Medicine and medical director of Liver Transplantation at Penn Medicine, and senior author of the study. (news-medical.net)
  • Participants were randomly assigned to receive 420mg silymarin, 700mg silymarin or a matching placebo administered three times/week for 24 weeks, a standard duration of treatment. (news-medical.net)
  • One group of 25 patients received 200 mg of silymarin three times a day for 4 months, while the remaining 26 received a placebo treatment. (biotech-weblog.com)
  • There is no evidence of a favourable influence on the evolution of viral hepatitis, particularly hepatitis C. In alcoholic liver disease, comparing with placebo, aspartate aminotransferase was reduced in the silymarin-treated groups (p = 0.01) while alkaline phosphatase was not. (uzh.ch)
  • In liver cirrhosis, mostly alcoholic, total mortality was 16.1% with silymarin vs. 20.5% with placebo (n.s. (uzh.ch)
  • liver-related mortality was 10.0% with silymarin vs. 17.3% with placebo(p = 0.01). (uzh.ch)
  • Ces patientes ont été soumises à une induction d'ovulation et ont reçu, sur la base d'une répartition aléatoire et en aveugle, de la silymarine (70 mg × 3 fois par jour) ou un placebo, dès le début du cycle d'induction. (who.int)
  • In conclusion, silymarin exerts beneficial effects on the early stages of liver pathogenesis, preventing and delaying liver carcinogenesis. (aacrjournals.org)
  • Besides anticarcinogenic effects, silymarin also exerts anti-inflammatory action in vivo ( 20 ). (jimmunol.org)
  • Silymarin, the active flavonoid complex, includes compounds that help exert a protective effect against substances that may be potentially harmful to the liver. (nutritionexpress.com)
  • Recent years have seen an explosion of scientific papers that deal with drugs from the fruits of milk thistle and its active substances silymarin (standardized mixture of flavonolignanes), thus justifying an updated systematic review. (longecity.org)
  • Unfortunately, natural (cancer cell killing) substances like, silymarin have been largely ignored by the mainstream media and Western medicine. (naturalhealth365.com)
  • Therefore, the objective of this review is to assess the clinical efficacy and safety of silymarin by application of systematic approach. (springer.com)
  • Silymarin has metabolic and cell-regulating effects at concentrations found in clinical conditions, namely carrier-mediated regulation of cell membrane permeability, inhibition of the 5-lipoxygenase pathway, scavenging of reactive oxygen species (ROS) of the R-OH type and action on DNA-expression, for example, via suppression of nuclear factor (NF)-κB. (springer.com)
  • Although there were no clinical end-points in the four trials considered in patients with alcoholic liver disease, histological findings were reported as improved in two out of two trials, improvement of prothrombin time was significant (two trials pooled) and liver transaminase levels were consistently lower in the silymarin-treated groups. (springer.com)
  • In numerous clinical studies, silymarin has been shown to have positive effects in treating virtually every type of liver disease including cirrhosis , hepatitis , jaundice , and chemical- or alcohol-induced fatty liver . (diagnose-me.com)
  • This RFA is a one-time solicitation to request for applications to perform multi-site Phase I/II clinical trials of silymarin for liver diseases. (nih.gov)
  • The National Center for Complementary and Alternative Medicine (NCCAM), in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health, of the U.S Department of Health and Human Services is seeking applications to perform Phase I/II clinical trials with silymarin for chronic liver diseases. (nih.gov)
  • Silymarin (SIL) prevents fatty liver disease in the clinical setting and in models of liver damage induced chemically. (ovid.com)
  • In clinical trials, the silymarin-phosphatidylcholine complex has worked better than silymarin by itself for treating liver disorders. (digitalnaturopath.com)
  • 4-10 Pre-clinical evidence suggests that silymarin can also promote a healthy inflammatory response at the cellular level. (lifeextension.com)
  • Clinical study of Silymarin in the prevention and treatment of liver diseases, PMID: 21466434. (wonderlabs.com)
  • Three compounds: silymarin, quercetin and kaempferol were evaluated for their in vitro antiviral activities against CHIKV using a CHIKV replicon cell line and clinical isolate of CHIKV of Central/East African genotype. (k-state.edu)
  • CONCLUSIONS: Based on the available clinical evidence it can be concluded - concerning possible risks /probable benefits - that it is reasonable to employ silymarin as a supportive element in the therapy of Amanita phalloides poisoning but also (alcoholic and grade Child 'A') liver cirrhosis. (uzh.ch)
  • In clinical trials, this new drug alone has done better than silymarin in the treatment of liver disorders [ 2 - 6 ]. (alliedacademies.org)
  • Milk thistle possesses a variety of compounds which are known as Silymarin. (vitanetonline.com)
  • Silymarin (the flavonoid extracted from milk thistle) and silymarin-derived compounds have been considered hepatoprotective (protecting the liver from damage) since the plant was first described in ancient times. (diagnose-me.com)
  • Hepato-protective compounds such as silymarin are beneficial not only for the liver but also for the overall health and vitality of the body. (lifeextension.com)
  • The active ingredient in milk thistle is silymarin, which is responsible for most of milk thistle`s beneficial properties - including liver support lowering cholesterol. (bodykind.com)
  • We conclude that available evidence suggests that silymarin may play a role in the therapy of (alcoholic) liver cirrhosis. (springer.com)
  • Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. (dogcancerblog.com)
  • Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway. (dogcancerblog.com)
  • Through real-time PCR analysis, we clarified a vital protective role of silymarin in mRNA regulation of genes involved in lipid metabolism and oxidative stress. (greenmedinfo.com)
  • With respect to alcohol abuse, silymarin is able to increase cellular vitality and to reduce both lipid peroxidation and cellular necrosis. (nih.gov)
  • Possible mechanisms which may be responsible for the inhibition of ethanol-induced liver lipid peroxidation by silymarin pretreatment include the following. (chiro.org)
  • Thus, by trapping oxygen-related free radicals, silymarin could hinder their interaction with polyunsaturated fatty acids and would abolish the enhancement of lipid peroxidative processes leading to MDA formation and light emision. (chiro.org)
  • Silymarin suppressed the TNF-induced production of reactive oxygen intermediates and lipid peroxidation. (jimmunol.org)
  • Preliminary research indicates that silymarin also stimulates RNA and DNA transcription in liver cells, which supports protein synthesis and cellular regeneration. (vitasprings.com)
  • In addition to its protective functions, silymarin stimulates damaged liver cells to regenerate. (supervits.com)
  • However promising results are being seen in treating Melasma with a cosmeceutical skin cream which contains Silymarin which is the active ingredient in the Milk Thistle plant. (sbwire.com)
  • They then introduce a new cosmeceutical skin cream which contains as its active ingredient Silymarin which is extracted from the common Milk Thistle plant. (sbwire.com)
  • Silymarin is the active ingredient in the milk thistle herb, which has been traditionally used for centuries to support liver functions. (tasmanhealth.co.nz)
  • Fortunately, silymarin - the active ingredient in milk thistle - is showing potential in preventing health issues like, liver disease. (naturalhealth365.com)
  • The available trials in patients with toxic (e.g. solvents) or iatrogenic (e.g. antispychotic or tacrine) liver diseases, which are mostly outdated and underpowered, do not enable any valid conclusions to be drawn on the value of silymarin. (springer.com)
  • Conclusions: Data presented here do not solve the question about the complex mechanism(s) of action of the medicinal herbal drug silymarin. (longecity.org)
  • Several studies using 'in vitro' and 'in vivo' cancer models suggest a potential of silymarin in such diseases. (longecity.org)
  • RÉSUMÉ Pour étudier les effets de la silymarine sur le développement folliculaire, nous avons recruté 40 femmes en bonne santé subissant une fécondation in vitro (FIV) en raison d'une infertilité masculine. (who.int)
  • The goal of this study was to determine if silymarin has in vitro effects on immune function that might have implications for its potential effect on HCV-induced liver disease. (uncg.edu)
  • How silymarin mediates its anticarcinogenic effects is not fully understood, but it has been shown that some of the effects are mediated through inhibition of receptor tyrosine kinases ( 16 ), cyclin-dependent kinases ( 17 , 18 ), TNF mRNA expression ( 19 ), and ornithine decarboxylase activity ( 13 ). (jimmunol.org)
  • Taken together, these results suggest that silymarin may exert a strong anticarcinogenic effect against PCA and that this effect is likely to involve impairment of erbB1-SHC-mediated signaling pathway, induction of CDKIs, and a resultant G 1 arrest. (aacrjournals.org)
  • The new study was designed to measure the potential benefit of increasing doses of silymarin in patients with chronic HCV. (news-medical.net)
  • In additional studies, treatment of cells grown in 10% serum with anti-epidermal growth factor receptor monoclonal antibody clone 225 or different doses of silymarin also resulted in significant inhibition of constitutive tyrosine phosphorylation of both erbB1 and SHC but no change in their protein levels. (aacrjournals.org)
  • This review does not aim to replace future prospective trials aiming to provide the 'final' evidence of the efficacy of silymarin. (springer.com)
  • A dose-response study was undertaken to determine if silymarin does have hyperprolactinemic properties in cycling swine. (gc.ca)
  • Contemporary research found that Silymarin has strong antioxidants that prevent free radicals from damaging liver cells. (tasmanhealth.co.nz)
  • Antioxidants such as silymarin and quercetin stabilize the membrane gangliosides and thus make biological membranes durable and increase cell viability. (alliedacademies.org)
  • According to studies, these mechanisms of action of Silymarin are effective for the prevention of hepatitis, cirrhosis, jaundice, and other liver health disorders. (tasmanhealth.co.nz)
  • They have been subjected to numerous scientific studies for decades to directly identify the link between silymarin and liver health support. (tasmanhealth.co.nz)
  • In addition, Silymarin Plus TM provides Beet root and Dandelion root, which are traditional botanicals often used to provide liver support and detoxification. (vitaglo.com)
  • In spite of some positive results in patients with acute viral hepatitis, no formally valid conclusion can be drawn regarding the value of silymarin in the treatment of these infections. (springer.com)
  • The purpose of this study is to determine the safety and tolerability of different dosages of silymarin on subjects with Hepatitis C or Non-Alcoholic Fatty Liver Disease. (clinicaltrials.gov)
  • Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metab Dispos. (clinicaltrials.gov)
  • LiverMarin has Silymarin and Sodium Ascorbate that may help prevent over-production of insulin, manage SGPT/SGOT levels, prevent liver diseases such as liver cirrhosis and can even help prevent the liver from Hepatitis A and B. If you feel like it's hard to get this product, do what I did. (starmometer.com)
  • Silymarin for the treatment of acute viral hepatitis? (digitalnaturopath.com)
  • In Europe, Silymarin is being recommended to control the symptoms and promote liver healing in cirrhosis, hepatitis, and jaundice. (tasmanhealth.co.nz)
  • Silymarin in non alcoholic fatty liver disease. (nih.gov)

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