General agreement or collective opinion; the judgment arrived at by most of those concerned.
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Presentations of summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus--often with findings and recommendations--on a subject of interest. The Conference, consisting of participants representing the scientific and lay viewpoints, is a significant means of evaluating current medical thought and reflects the latest advances in research for the respective field being addressed.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Societies whose membership is limited to physicians.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Established cell cultures that have the potential to propagate indefinitely.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Proteins prepared by recombinant DNA technology.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Nucleic acid sequences involved in regulating the expression of genes.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Proteins found in any species of bacterium.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
The rate dynamics in chemical or physical systems.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
The relationships of groups of organisms as reflected by their genetic makeup.
Elements of limited time intervals, contributing to particular results or situations.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The functional hereditary units of BACTERIA.
Any method used for determining the location of and relative distances between genes on a chromosome.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
Deletion of sequences of nucleic acids from the genetic material of an individual.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Transport proteins that carry specific substances in the blood or across cell membranes.
Sequential operating programs and data which instruct the functioning of a digital computer.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Biochemical identification of mutational changes in a nucleotide sequence.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Computer-based representation of physical systems and phenomena such as chemical processes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Deoxyribonucleic acid that makes up the genetic material of fungi.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins obtained from ESCHERICHIA COLI.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Genotypic differences observed among individuals in a population.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Proteins found in any species of fungus.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Proteins found in any species of virus.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
The functional hereditary units of FUNGI.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
A sequential pattern of amino acids occurring more than once in the same protein sequence.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Two-dimensional separation and analysis of nucleotides.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
The sum of the weight of all the atoms in a molecule.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Several conservative sources sided with Trump to embrace and promote the Spygate conspiracy theory, including the Fox & Friends ... "Mueller Pick Meets a Rare Bipartisan Consensus". The Atlantic. Archived from the original on May 18, 2017. Retrieved May 18, ... "Rare bipartisan moment: Both sides embrace Robert Mueller as special counsel". USA Today. Archived from the original on May 18 ...
Mayer, Jane (May 2009). The Dark Side. New York: Anchor Books. ISBN 978-0-307-45629-8. Blum, Howard (December 1, 2017). "How ... "Mueller Pick Meets a Rare Bipartisan Consensus". The Atlantic. Archived from the original on May 18, 2017. Retrieved May 18, ... "Rare bipartisan moment: Both sides embrace Robert Mueller as special counsel". USA Today. Archived from the original on May 18 ... Mayer, Jane (2009). The Dark Side. New York: Anchor Books. ISBN 978-0307456298. Graff, Garrett (2011), The Threat Matrix: ...
ISBN 0-07-310218-0 "Working-Class Radicalism in the Gilded Age." In Conflict and Consensus in American History. 7th ed. Allen F ... ISBN 0-252-00953-3 "Was the American Labor Movement Radical?" In Taking Sides: Clashing Views on Controversial Issues in ...
The website's critical consensus reads, "A calm, charismatic performance from Robert De Niro nearly saves the movie, but ... DiOrio, Carl (2009-12-06). "'Blind Side' tops 'New Moon' at boxoffice". The Hollywood Reporter. Archived from the original on ... Retrieved 2009-12-10.{{cite web}}: CS1 maint: archived copy as title (link) Ryan, Tim (2009-11-03). "Critics Consensus: ... the critic's consensus praises Robert De Niro for having "intensity and presence that shines through even when he's not playing ...
There is no clear consensus on its authorship. It is said to possibly have been the work of a student of Raphael, and that he " ... A brown structure is on the right side of the landscape. The painting takes its name from having been in the Northbrook ...
Decisions are more well-rounded and humble, rather than one-sided and arrogant. Contemplation: members examine themselves. They ... They make decisions and reconcile their differences through consensus. Realism: members bring together multiple perspectives to ... Inclusivity Commitment Consensus Based on his experience with community building workshops, Peck says that community building ... and consensus: members accept and embrace each other, celebrating their individuality and transcending their differences. They ...
Hall, Mimi (March 25, 2010). "Both sides of abortion issue quick to dismiss order". USA Today. "DNC Platform Includes Historic ... Lucas, Fred (July 25, 2016). "Democratic Platform Topples Consensus on Abortion". The Daily Signal. Retrieved April 17, 2017. " ...
Meta-Analytics: Consensus Approaches and System Patterns for Data Analysis. Elsevier, 2018. ISBN 9780128146231 Mayer, Joceli; ... Fundamentals and Applications of Hardcopy Communication: Conveying Side Information by Printed Media. Springer, 2018. ISBN ...
Al Jazeera, 17 June 2015 Hamas Rejects 'One-sided' Dissolution of Palestinian Government. Haaretz, 17 June 2015 Abbas to ... Xinhua, 1 July 2015 New cabinet reshuffle on consensus government. Ma'an, 1 July 2015 (Webarchive template wayback links, ... "consensus government". Finance Minister of the Palestinian National Authority Foreign Affairs Minister of the Palestinian ...
... "both sides of the Taiwan Straits agree that there is only one China. However, the two sides of the Straits have different ... opinions as to the meaning of 'one China'." This would later known as the 1992 consensus. The council had already been out of ...
B-side is an instrumental version of "Election Day" "Election Day" (Consensus Mix) - 8:39 "Election Day" (Single version) - 4: ... Consensus Mix 8:39 - 12" and promo video version. "She's Moody and Grey, She's Mean and She's Restless" 4:28 - Instrumental B- ... It was released by Parlophone Records in October 1985 and subsequently hit the Top 10 on both sides of the Atlantic, peaking at ... side; the title comes from the song's first verse. Cryptic Cut/Fact and Story Mix 9:06 - Largely instrumental, featuring ...
Harvey Shepherd, "Vandals kick off referendum campaign; Ex-mayors on both Yes and No side," Montreal Gazette, 28 September 1995 ... "Monteregie commission can't reach consensus," Montreal Gazette, 23 March 1995, A18. ... he was the first mayor of a major city in Quebec to support the Parti Québécois and openly supported the Oui side in the 1980 ...
1999). The consensus building handbook: a comprehensive guide to reaching agreement. Thousand Oaks, CA: Sage Publications. ISBN ... Ury, William (2000) [1999]. The third side: why we fight and how we can stop (Revised ed.). New York: Penguin Books. ISBN ... Egan, Gerard (1994). Working the shadow side: a guide to positive behind-the-scenes management. San Francisco: Jossey-Bass. ...
Young Communist League Worley, Matthew (September 2012). "Shot By Both Sides: Punk, Politics and the End of 'Consensus'". ...
Current recommendations are based on consensus guidelines from around the world. Side effects can include allergic reactions ... Side effects can include allergic reactions such as anaphylaxis, infection, and lung injury. Bacterial infections are ...
The Church had merely sided with the scientific consensus of the time. Pope Urban VIII asked that his own views on the matter ... In such a case, we should not rush in headlong and so firmly take our stand on one side that, if further progress in the search ... A 2009 study from the Pew Research Center on Americans perceptions of science, showed a broad consensus that most Americans, ... Only on one issue does a significant portion of the public deny strong consensus for religious reasons: evolution. The ...
They move their arms side to side by means of ball-and-socket joints. Tropical species tend to contrast color from the ... There is currently no consensus as to the subdivision of the Ophiurida. The order has been divided into the following suborders ...
... the talks themselves ended without a consensus between the two sides. The talks finally collapsed but were regarded as both a ... Chin died of cancer at the age of 88 at a private hospital in Bangkok, with only his 50-year-old niece by his side, on the ... The book named Alias Chin Peng: My Side of History, was published in 2003. Another book, Dialogues with Chin Peng: New Light on ... Special Malaysian government troops going by the name "Senoi Praaq" prove to be a thorn in Chin Peng's side. 2 December 1989: A ...
The DPP also denies that there ever was a consensus in 1992. Both sides supports opening of the three links with mainland China ... The strategy of both sides, as was the case in 2004, was to persuade voters that it can best maintain the status quo and ... "1992 Consensus" which presumes one China, different interpretations. During the campaign, Ma articulated a three noes policy, ... hopes to work together towards peaceful development of both sides of the Taiwan Strait) China likely to be pleased at outcome ...
Rare but serious side effects include a prolonged erection (priapism) that can lead to damage to the penis, vision problems, ... Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, Russell RO, Zusman RM (January 1999). "ACC/AHA expert consensus document. ... Common side effects include headaches, heartburn, and flushed skin. Caution is advised in those with cardiovascular disease. ... "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 11 July 2018. Peterson K ( ...
The No side, supported by the three major UK parties, secured a 55% to 45% majority for Scotland to remain part of the United ... P. J. McLoughlin finds the consensus of scholars is that it was a significant factor contributing to the development of the ... On the economic side of things, the value of the British pound declined sharply after the results of the election were made ... Her early tax policy reforms were based on the monetarist theories of Milton Friedman rather than the supply-side economics of ...
The dispute culminated in this case where the test was reformulated to reflect both sides of the dispute. The unanimous court, ... However, there remains a consensus on the purpose and approach, which he enumerates. First, the approach must not be mechanical ...
Only once did he find himself on the losing side in a constitutional case. In that case-Ogden v. Saunders in 1827-Marshall set ... Marshall regularly curbed his own viewpoints, preferring to arrive at decisions by consensus. ... is located on the east side of the park), and a third is situated on the grounds of the Philadelphia Museum of Art. Marshall, ...
It soon became clear that consensus lay on the side of the defence. Harcourt was disgusted by the public's sentiment and became ... The Attorney-General felt that a life sentence would not resist the attack of public consensus. He noted that the court had ...
On both the theoretical and the empirical sides, experts have not reached any consensus. Between 1877 and 1968, 700 people have ...
Second, the other side of the dialogue is Paul's conversion and calling to follow Christ in the early 30s. The most probable ... The scholarly consensus is that Paul wrote the Epistle to the Romans. C. E. B. Cranfield, in the introduction to his commentary ... Not all climbers have taken the same route up its sheer sides, and there is frequent disagreement on the best approach. What ... Lüdemann is the only serious challenge to the consensus of mid to late 50s.[incomplete short citation] There is strong, albeit ...
Consensus is growing that the script has essentially been deciphered. Coins from Side were first discovered in the 19th century ... S I.1.2 Apollonios bilingual from Side (1949). S3 & S4 = S I.2.1-2 Strategos dedications from Side (1964). S5 = S II.1.1 ... Since the 2010s consensus has grown with regard to the transliteration of the characters: The meaning of two-thirds of the ... In 1914, an altar came to light in Side with a Greek inscription and a Sidetic one, but the latter could not be deciphered. It ...
The pain can radiate to the left side of the jaw and into the left arm. Myocardial infarction can rarely present as referred ... Currently there is no definitive consensus regarding which is correct. The cardiac general visceral sensory pain fibers follow ... Referred pain is often experienced on the same side of the body as the source, but not always. There are several proposed ... where pain is often felt in the left side of neck, left shoulder, and back rather than in the thorax (chest), the site of the ...
On 23 September 2020, Bordin was signed by Serie C side Casertana on a season-long loan deal. Two weeks later, on 7 October, he ... In January 2022 he left the club by mutual consensus. On 9 August 2022, Bordin joined his hometown club Latina on a one-year ... Bordin was signed by Serie B side Perugia on a season-long loan deal. On 30 September he made his debut for Perugia in Serie B ...
... on the American side, the other members of North American Free Trade Area (Canada and Mexico); and on the European side, the ... However the agreement is negotiated as a whole, so no topic's text is finalised until full consensus is reached. Negotiations ... The European side has been pressing for the agreement to include a chapter on the regulation of financial services; but this is ... On the US side, the procedure is similar: only Senators and USTR negotiators may access the documents and must comply with ...
Instead, they apparently lived side by side in eastern Africa for almost half a million years". ... "Greater than 99% consensus on human caused climate change in the peer-reviewed scientific literature". Environmental Research ... A war involves the use of lethal weapons as both sides try to kill the other. It is estimated that during the 20th century, ...
Brand name:Lasix - Generic name: Furosemide Prescription Drug Information, Side Effects - PDRHealth ... American College of Veterinary Internal Medicine consensus statement.»։ Journal of Veterinary Internal Medicine / American ...
This COP15 Side Event will feature statements and input from the heads of UNDESA, UNDP, GEF, WIPO, UNIDO, UNEP, IRENA as well ... build consensus, make vigorous efforts and enhance co-operation."[128] India's environment minister, Jairam Ramesh, has been ... Side Event on Technology Transfer[edit]. The United Nations Industrial Development Organisation (UNIDO) and the Department of ... "DSD :: Areas of Work:: Technology - Meetings & Workshops - COP15 Side Event, December 2009". Un.org. Retrieved 19 December 2009 ...
The study of the achievement gap can be addressed from two standpoints-from a supply-side and a demand-side viewpoint of ... Scientific consensus tells us that there is no evidence for a genetic component behind differences in academic achievement ... In classrooms, students can communicate internally, or they can work side by side with others who are located thousands of ... Supply-side arguments focus on the provision of education and resources and the systemic structures in place that perpetuate ...
The website's critics consensus reads: "Hands of Stone's strong cast and fascinating real-life story aren't enough to ... In the film's epilogue, it states that Plomo was in Durán's side for each fight until Plomo's death in 2012; Leonard and Durán ... remembering how American troops took over the country by owning the Panama Canal-leading to conflict between the sides in 1964 ...
The inscription Jesus Christ in Greek: IC (Iesous) on the left side bar and XC (Xhristos) on the right side bar, with a sun on ... Holy tradition and the patristic consensus[edit]. "That faith which has been believed everywhere, always, and by all", the ... The Archdiocesan Cathedral of the Holy Trinity on New York City's Upper East Side is the largest Eastern Orthodox Christian ... In other cases, opinions differ, no consensus is forthcoming, and all are free to choose. With agreement among the Church ...
Several major atrocities were committed by both sides.[34] Civil war in Mandatory Palestine. Main article: 1947-1948 civil war ... They reached consensus that there should be no recognition, no peace, and no negotiations with the State of Israel, the so- ... The beliefs of the various sides and their ideas and views of the chosen people in their policies with regard to the "Promised ... As a result of Israel's victory in the 1948 Arab-Israeli War, any Arabs caught on the wrong side of the ceasefire line were ...
The sac is not implanted on the midline, but eccentrically (to one side of the uterine cavity line). ... Review of the Society of Radiologists in Ultrasound 2012 Consensus Panel Recommendations". RadioGraphics. 35 (7): 2135-2148. ...
Grace is, on one side, "the free act of God," and, on the other side, the effect of this act, the gratia infusa or gratia ... In that the will wills the end, it wills also the appropriate means, chooses freely and completes the consensus. Whether the ... Furthermore, Christ's human nature partook of imperfections, on the one side to make his true humanity evident, on another side ... But from another side God is the cause of all things, so he is efficacious also in sin as actio but not as ens. The devil is ...
Does not engage in consensus building: a. repeatedly disregards other editors' questions or requests for explanations ... Make a strong effort to see their side of the debate, and work on finding points of agreement. Do not confuse "hearing" with " ... If editor continues to ignore consensus of any decision reached at ANI: *Again, request assistance at Wikipedia:Administrators ... Any substantive edit to this page should reflect consensus. When in doubt, discuss first on the talk page. ...
Critics have likened the song to West Side Story.[52][47] "This Hollywood Life" is one of the few rockers on the album. A ... Suede's manager Charlie Charlton made a final attempt to reach consensus between the two parties; however, during a tense phone ... Additional bonus material includes demos, all b-sides from the singles "Stay Together", "We Are the Pigs" and "The Wild Ones". ... b-side to "The Wild Ones". The album charted at no. 35 on Billboard's Heatseekers Albums chart 12 November.[76] And also ...
A type of infobox, a taxobox is a taxonomy table positioned at the right side of an entry for a species of organism (or for a ... Articles become featured articles when a FAC gets consensus for promotion.. FAC. Featured article candidate, an article that ... It can often be found on the quickbar (on the left side in most skins), and is a page that lists the collaboration of the week ... Any individual topic within Wikipedia; the web page without the top, bottom and side bars. Pages include articles, stubs, ...
Another official selected by the consensus of the local community was the kadkhoda, who functioned as a common law ... The Judge is seated at one end of the room having a writer and a man of law by his side. ... and consensus should be used as sources to derive verdicts (fatāwā). Unlike Usulis, Akhbari did and do not follow marjas who ... who were authorized to sit by his side on various occasions.[190] The Chief Physician (Hakim-bashi) was a highly considered ...
New insights into the evolution of neural crest cells, support the consensus that all vertebrates share these cells, which ... uniting to form a common aperture on the ventral side known as the branchial opening. The esophagus is also connected to the ... The dorsal and ventral muscles located towards the side of the hagfish body are connected to spinal nerves. The spinal nerves ... molecular data are almost unanimously in consensus of cyclostome monophyly, with more recent work being directed at shared ...
... is a generally moontainous kintra on the wastren side o central soothren Great Breetain.[63] It is aboot 170 mile (270 km ... industrial dissension an poleetical militancy haed began tae unnermine Leeberal consensus in the soothren coalfields.[42] In ...
The diversion of wealth from Portugal by the Habsburg monarchy to support the Catholic side of the Thirty Years' War also ... there is consensus among professional historians that the most adequate term is Hispanic monarchy ... and Spain the Pacific Ocean and both sides of Central and South America, while both shared the Atlantic Ocean space. ... took advantage of the fact that the Castilian troops were occupied in the other side of the peninsula. The rebels killed ...
The fort's main gate, located on the east side of the stockade, had not been closed by the garrison troops ... No sentries ... While the interpretation of this event varied from tribe to tribe, one consensus was universally accepted: the powerful ... Fears of land-hungry settlers and need for European manufactured goods led the Muscogee to side with the British, but like many ... During the American Revolution, the Upper Creeks sided with the British, fighting alongside the Chickamauga (Lower Cherokee) ...
Side effects[edit]. Overall, TENS has been found to be safe compared with pharmaceutical medications for treating pain.[4] ... "there is no consensus and it may be possible to safely deliver these modalities in a proper setting with device and patient ... "Transcutaneous Electrical Nerve Stimulation: Side Effects & Uses".. *^ Dac Teoli, Jason An (2019). Transcutaneous Electrical ... Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve.[33] ...
Consensus in many debates and discussions should ideally not be based upon number of votes, but upon policy-related points made ... පඹ රූකඩ (Strawman socks): Creating a separate account to argue one side of an issue in a deliberately irrational or offensive ... Meatpuppetry is the use of editors as proxies to sway consensus. While Wikipedia assumes good faith, especially for new users, ... or communities of people who agree with you for the purpose of coming to Wikipedia and supporting your side of a debate. If you ...
"International consensus conferences in intensive care medicine: Ventilator-associated Lung Injury in ARDS. This official ... For infants who require opioids for pain, the potential side effects of opioids include problems with feeding, gastric and ...
... the Unitin for Consensus group o the UN, an the Paceefic Alliance tred bloc. Bi 2050, Mexico coud potentially acome the warld's ... Drivin side. richt. Cawin code. +52. ISO 3166 code. MX. Internet TLD. .mx. ...
Please discuss this matter at this template's entry at templates for discussion to help reach a consensus. ... Please discuss this matter at this template's entry at templates for discussion to help reach a consensus. ... Please discuss this matter at this template's entry at templates for discussion to help reach a consensus. ... Please discuss this matter at this template's entry at templates for discussion to help reach a consensus. ...
Main articles: Wikipedia:Vandalism, Wikipedia:Dispute resolution, Wikipedia:Consensus, Wikipedia:Sock puppet, Wikipedia: ... You may also search for articles, using the search box on the left side of the screen. ... Wikipedia is written by consensus - an approach that has its pros and cons. Censorship or imposing "official" points of view is ... In reality, the process of reaching consensus may be long and drawn-out, with articles more fluid or changeable for a long time ...
Their consensus view was that the Franks, as the western Europeans were known, lived as a minority society that was largely ... The patriarchs of Alexandria, Antioch, and Jerusalem sided with the Ecumenical Patriarch against the Papacy, but the East-West ... As there was no consensus on what should happen if the boy king died, it would be for the pope, the Holy Roman Emperor, the ... The new consensus was the society was segregated with limited social and cultural interchange. Focusing on evidence of social, ...
The Bishops' Conference of Scotland Archived 11 May 2008 at the Wayback Machine uses both styles side by side. On diocesan ... There is general disagreement about the origin of the term, but a chief consensus that "cardinalis" is etymologically from the ... The coat of arms of a cardinal (who is a bishop) is indicated by a red galero (wide-brimmed hat) with 15 tassels on each side ( ... with Mary and John to each side. The ring includes the pope's coat of arms on the inside.[65] ...
When opened from the left cover the edition features bilingual text with side-by-side English/Aramaic translation. The margins ... apparently representing a consensus view. The rabbis recorded in the Mishnah are known as the Tannaim (literally, "repeaters," ... presents the Talmud and a summary of the halachic codes side by side, so as to enable the "collation" of Talmud with resultant ... A page number in the Vilna Talmud refers to a double-sided page, known as a daf, or folio in English; each daf has two amudim ...
The website's critical consensus reads, "Ocean's Thirteen reverts to the formula of the first installment, and the result is ... Side Effects (2013). *Behind the Candelabra (2013). *Logan Lucky (2017). *Unsane (2018) ...
In 2011, the American Urological Association released consensus-based guideline for the diagnosis and treatment of interstitial ... Advantages of this treatment approach include direct contact of the medication with the bladder and low systemic side effects ...
A Case Report on a Rare but Serious Debilitating Side-Effect of Fluoroquinolone Administration» (en anglès). J Investig Med ... Ferner, RE; Gutmann, DH «International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis» ( ... expert consensus proposal» (en anglès). Mod Pathol, 2018 Des; 31 (12), pp: 1770-1786. DOI: 10.1038/s41379-018-0110-y. PMC: ...
... despite Pingtung and Taipei being completely distinct areas on opposite sides of Taiwan, causing an uproar among Taiwanese ... Taiwan consensus. *Taiwan independence movement. *Theory of the Undetermined Status of Taiwan ...
CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative ... Predominant Right-Sided Heart Failure. Ascites, congestive hepatomegaly, and anasarca due to elevated right-sided heart ... Right-sided venous congestion is characterized by hepatosplenomegaly and, less frequently, with edema or ascites. Jugular ... Hepatomegaly is prominent in patients with chronic right-sided heart failure, but it may occur rapidly in acute heart failure. ...
Indian side violated bilateral agreements, important consensus, claims China. Written by Epilogue on 3rd September 2020. ... "The Indian side claims it `pre-empted Chinese military activity. Indias statements reveal the fact that the Indian troops ... India had said on Tuesday that it has taken up the matter of "recent provocative and aggressive actions" with the Chinese side ... The talks between the two sides have been going on for the last few months including five Lieutenant general-level talks. ...
Predominant Right-Sided Heart Failure. Ascites, congestive hepatomegaly, and anasarca due to elevated right-sided heart ... CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative ... Right-sided venous congestion is characterized by hepatosplenomegaly and, less frequently, with edema or ascites. Jugular ... Hepatomegaly is prominent in patients with chronic right-sided heart failure, but it may occur rapidly in acute heart failure. ...
Analyst consensus points to a buy rating. The range between the target price high and the target price low is between 65 and 22 ... Synchrony Financial - Consensus indicates 51.5% upside potential. Andrew Miller May 22, 2022. ... The potential market capitalization would be $24,662 million based on market consensus. ...
Lawless, John (November 22, 2016). "Special Cs side trip to Louisville". Bluegrass Today. Retrieved July 11, 2017. Stuart, ... Special Consensus was a state where spiritual and physical good things physically came together. Plus, a band is a consensus of ... Official website The Special Consensus at AllMusic The Special Consensus discography at Discogs (Articles with short ... Special Consensus tours frequently across the U.S. Every other year, the band has also toured Ireland and the United Kingdom, ...
A killed whole-cell vaccine could be considered if it passed phases I, II, and III clinical studies; had minimal side effects; ... Limmathurotsakul D, Dance DA, Wuthiekanun V, Kaestli M, Mayo M, Warner J, Systematic review and consensus guidelines for ... Consensus on the Development of Vaccines against Naturally Acquired Melioidosis On This Page ... Consensus on the Development of Vaccines against Naturally Acquired Melioidosis. Volume 21, Number 6-June 2015 ...
The dark side of consensus in Tunisia: Lessons from 2015-2019. Sharan Grewal and Shadi Hamid ...
This Side of Peace: A Personal Account. 04 Aug, 1995. Consensus Rule Processes. 13 Aug, 1998 ...
Worley, M. (2012) Shot by both sides: Punk, politics and the end of "Consensus". Contemporary British History, 26 (3). pp. 333- ... Punk, Consensus, Youth, Fascism, Communism. Additional Information:. Special Issue: Youth Culture, Popular Music and the End of ... consensus in the 1970s, the far left and far rights focus on cultural expression cut across the basic foundations on which ...
NIH Consensus Statement. Phenylketonuria: Screening and Management. October 16-18, 2000. Pediatrics 2001;108:972-82. View ... Side Effects. Tyrosine is LIKELY SAFE when taken by mouth in food amounts and POSSIBLY SAFE when taken by adults short-term in ... Stay on the safe side and avoid use.. Overactive thyroid (hyperthyroidism) or Graves disease: The body uses tyrosine to make ... Some people experience side effects such as nausea, headache, fatigue, heartburn, and joint pain. ...
SIDE EVENT Friday 3 June 17:15-18:30 CEST Stockholmsmässan, Room 3 Organizers: EAT, The Lancet, Stockholm Resilience Centre, ... SIDE EVENT. Friday 3 June. 17:15-18:30 CEST. Stockholmsmässan, Room 3. Organizers: EAT, The Lancet, Stockholm Resilience Centre ... Global Kick-off of the EAT-Lancet 2.0 Commission: Building consensus and setting clear food system targets for people and ... Focused on building scientific consensus among a diversity of food system actors-from production to consumption-this event will ...
... these latest embody probably the largest consensus, and while perhaps not the most practical, are possibly the most erudite. ... Continued attention to side effects.. Prof. Mancia emphasized that because many patients will need to take more than 1 drug ... ESH 07: New Consensus Hypertension Guidelines From the European Society of Hypertension/European Society of Cardiology (ESH/ ... Cite this: ESH 07: New Consensus Hypertension Guidelines From the European Society of Hypertension/European Society of ...
Side 1:. Pass out 3 x 5 cards to all participants to write on. Then ask the question:. What is the worst possible outcome of ... The talking circle is the centerpiece of the consensus process because it encourages respectful listening. If you can only ... Side 2:. What are the best possible outcomes of this workshop?. (After asking the question, wait, in silence, until all are ... The consensus community. There are two kinds of groups that I work with. Most groups are in a conflict common to them all, ...
Thats where a pipeline at defensive side is hard to pick on consensus right now. Im not sure what consensus says for 2023 ... It did get a readout from the U.S. side as well as the Chinese side. It seems like the one agreement is nobody wants war. But ... So let me bring you the US side. And I imagine well get the Chinese side of things a little bit later this morning as well. ... Thats why I think expectations are fairly managed on both sides, certainly on the Chinese side. I think on the U.S. and global ...
Consensus. Revisions. Funds. Summary. Most relevant. All News. Analyst Reco.. Other languages. Press Releases. Official ... Arbitral Tribunal Sides With Bayer in Breach of Contract Case from BASF. ...
Nowhere is it mentioned that this is not the scientific consensus; only one side is presented, the anti-vaccine side. ... Indeed, the consensus in the field is that while there is overwhelming evidence that autism is mostly, perhaps entirely, ... However, the situation has now degenerated - on one side are hysterical corporate promoters, on the other are hysterical autism ... To the knowledgeable reader or reviewer, a botched up introduction section that misrepresents the scientific consensus and the ...
Just a little side note here about motorola. The general consensus is that motorola is screwing up. Motorola tends to use ... On my side, Im more than happy with my iBook with its G3 running at 700Mhz. In term of productivity, Ive got the right tools ... On the flip side, Windows has been improving, and it truely is getting better. Microsoft is making my work and my life easier ...
Special Consensus. Jacklene. Scratch Gravel Road / Compass Records. The Spinney Brothers. Cabin On The Mountain. ... Sunny Side Up with Bruce. Sun Jun 03, 2012 9am - 11:30am ... Country Side Of Bluegrass / New Music Deals. Akira Otsuka. ...
Consensus boilerplate Unknown RFC Editor Note (None) IESG IESG state RFC 1980 (Historic) ... 2. Client-Side Image Map Extension 2.1 Syntax Adding a USEMAP attribute to an IMG element indicates that it is a client-side ... either a client-side or server-side image map. The argument to USEMAP specifies which map to use with the image, by specifying ... An document can be written so that a client-side image map can have three different fallback behaviors. First, the document can ...
... cancelled the contract for Bjorn Lomborgs Consensus Centre on May 8 after a passionate emotional reaction to the plan. In a ... Our side is - and always will be - that of the 99%.. Our goal is not only to expose the lies, hypocrisy and bias of the ... Read more about Bjorn Lomborg and his Concensus Centre here. Federal Education Minister Christopher Pyne tweeted: "What a sad ... The University of Western Australia (UWA) cancelled the contract for Bjorn Lomborgs Consensus Centre on May 8 after a " ...
The Ukrainian side either remains silent or speaks in different voices. Why is there no consensus among Ukraines political ... Lytvyn, who in your opinion has provoked this problem, this scandal? The Ukrainian side or Russia? Many now say that Russia is ... To shout out my own statements without knowing the essence of talks and without knowing what the Ukrainian side proposes would ... we dont need to sign a document that could resemble a surrender of one of the sides. ...
There is a strong scientific consensus forming around this approach. A new paper signed by more than 11,000 scientists argues ... The dark side of the Nordic model. Scandinavian countries may top every ranking on human development, but they are a disaster ...
P values of consensus motifs generated by HOMER29 using one-sided binomial test. f, KEGG and GO enrichment analysis of YTHDF1 ... Mean ± s.e.m., two-sided unpaired Students t-test (a, c, e, g-i); two-sided log-rank (Mantel-Cox) test (b). ... Mean ± s.e.m., two-sided unpaired Students t-test (a-c, f) or one-sided unpaired Students t-test (d). ... Mean ± s.e.m., two-sided unpaired Students t-test (e) or one-sided unpaired Students t-test (f). ...
Japanese and Korean Soups and Side Dishes. January 14, 2023 @ 10:30 am - 12:30 pm ... Introduction to Consensus Decision-Making for Groups. April 19, 2016 @ 5:30 pm - 7:00 pm. ... Learn about consensus decision making - its effective, empowering, and vibrant. Get away from being either the dominator or ... https://www.eventbrite.com/e/introduction-to-consensus-decision-making-for-groups-tickets-21595095512. ...
If either side fails, the group that has traveled the furthest wins. ... Overwatch 2 , Critical Consensus The follow up to the 2016 hero shooter is here but critics debate whether it feels like a full ...
Consensus. Islanda, quando il popolo sconfigge leconomia globale.. Il Giorno Fuori dal Tempo, Il significato energetico del 25 ... Lipitor: Side Effects And Natural Remedy. AIDS: No Gold Standard For HIV Testing. Lipitor: Side Effects And Natural Remedy. ... Lipitor: Side Effects And Natural Remedy. Serious side effects have been reported for Lipitor and other cholesterol-lowering ... She has been having many side-effects and the doctors just give her more drugs to cover up these side-effects. I did some ...
Road to Consensus: Latashá. CoinDesk via Yahoo Finance· 8 months ago. And theyre like, "I was so worried about that thing at ... one point, but now Im not so worried about it anymore." But then on the other side, we have... ...
What do you think about the pre-consensus topic? What side do you agree with and why? Let us know your thoughts on this subject ... Also Read: Bitcoin Cash Developers Debate an Idea Called Pre-Consensus. Bitcoin Cash and the Pre-Consensus Idea. Not long ago ... pre-consensus. Some developers believe pre-consensus could help with block time speeds, zero-confirmation transactions, and ... Other BCH Proponents Bolster Séchets Pre-Consensus Idea Although, there are a lot of people who support Séchets idea of ...
  • This all follows on from Naomi Oreskes' investigation into the existence of a consensus in the literature basically on the question as to whether the future holds an unusual amount of climate disruption. (blogspot.com)
  • Authors of seven climate consensus studies - including Naomi Oreskes , Peter Doran , William Anderegg , Bart Verheggen , Ed Maibach , J. Stuart Carlton , and John Cook - co-authored a paper that should settle this question once and for all. (skepticalscience.com)
  • On 3 December 2004, Science published an article entitled "The scientific consensus on climate change" by Naomi Oreskes (Vol 306, Issue 5702, 1686). (populartechnology.net)
  • The Special Consensus is an acoustic bluegrass group led by banjoist Greg Cahill. (wikipedia.org)
  • They began playing house parties, but in 1975 Cahill and bassist Marc Edelstein decided to pursue a music career for a few years as Special Consensus. (wikipedia.org)
  • Special Consensus was a state where spiritual and physical good things physically came together. (wikipedia.org)
  • As of 2021, the Special Consensus membership has included 18 guitarists, 12 bass players, 18 mandolin players, and two fiddlers. (wikipedia.org)
  • Special Consensus tours frequently across the U.S. Every other year, the band has also toured Ireland and the United Kingdom, through at least 2017. (wikipedia.org)
  • In 1984, The Special Consensus initiated the Traditional American Music (TAM) Program, in which they introduce students and teachers to bluegrass in schools across the country. (wikipedia.org)
  • Special Consensus has also been involved with IBMA's Bluegrass In The Schools (BGIS) program. (wikipedia.org)
  • In addition, Special Consensus provided the instrumentation for a Discover Bluegrass DVD. (wikipedia.org)
  • In 2016, Special Consensus was awarded the IBMA Instrumental Recorded Performance of the Year for their version of "Fireball. (wikipedia.org)
  • Every five years, current and past members of the Special Consensus gather for and perform in an anniversary concert, often at Old Town School of Folk Music in Chicago. (wikipedia.org)
  • For instance , "In the United States, for example, the National Institutes of Health promotes about five to six consensus panels per year, and organizes this knowledge by means of a special Consensus Development Program, managed by the NIH's Office of Disease Prevention (ODP). (blogspot.com)
  • According to some analysts, however, the outstanding issues between the two sides are not likely to be resolved soon as the JI refused to call off its protest and conditioned it with certain changes in the local government law. (dawn.com)
  • The analysts have set a $175 price objective, which compares with a much higher consensus target of $194.35. (247wallst.com)
  • The consensus among sell-side analysts is that the U.S. defense budget has entered a new up-cycle. (aviationweek.com)
  • Sell-side analysts anticipate that Fate Therapeutics will post -3.4 earnings per share for the current fiscal year. (etfdailynews.com)
  • The company reported ($1.32) earnings per share for the quarter, missing analysts' consensus estimates of ($1.04) by ($0.28). (reporter.am)
  • Sell-side analysts forecast that Alteryx will post -2.75 EPS for the current year. (reporter.am)
  • On 12 October 2022, a high-level side event will be held to discuss institutionalizing participatory governance in the Eastern Mediterranean Region. (who.int)
  • La información en esta página debería ser considerada como ejemplos de información de antecedentes para la temporada de influenza 2021-2022 para la práctica médica respecto del uso de medicamentos antivirales contra la influenza. (cdc.gov)
  • Since the election was called, two points of consensus emerged from political experts on both sides of the aisle. (columbian.com)
  • In a time when bipartisanship may seem a relic from days past, there's an enormous opportunity for wise heads on both sides of the aisle to put aside political differences on this particular issue. (kff.org)
  • History tells us that when such a political consensus emerges on both sides of the aisle, we may be moving toward a cultural and political tipping point. (yesmagazine.org)
  • Any erosion of support should concern Israel's friends on both sides of the political aisle, and we call in particular on leaders and donors in Senator Paul's party to repudiate his comments and ensure that American leadership around the world is not threatened by this irresponsible proposal,' the statement issued by J Street read. (eurasiareview.com)
  • Individuals and families, insurance companies, doctors and doctors' groups like the American Medical Association (AMA), businesses large and small, members of Congress on both sides of the aisle , and a determined president are all advocating sweeping changes. (neighborhoodlink.com)
  • The fundamental way out of impasses in China-US relations is to seriously implement the consensus reached by the leaders of both countries. (globaltimes.cn)
  • The early claims of 97% 'consensus': In 1992, former Vice President Al Gore reassured his listeners, "Only an insignificant fraction of scientists deny the global warming crisis. (climatedepot.com)
  • Ms Tsai has refused to adhere to the 1992 Consensus, angering people on both sides of the Strait. (straitstimes.com)
  • Scientists change their minds on the basis of the evidence, and a consensus emerges over time. (skepticalscience.com)
  • Perhaps that's why so many of them get so angry about openly partisan journalism from the other side. (theatlantic.com)
  • At a time when Congress has been torn by partisan battles, 24 ideologically disparate leaders representing the health care industry, corporations and unions, and conservative and liberal groups have been meeting secretly for months to seek a consensus on proposals to provide coverage for the growing number of people with no health insurance," writes Robert Pear for The New York Times . (galen.org)
  • To reinforce this process the national media provides the left and right versions of an issue in an effort to have a "balanced" discussion no matter how fake each partisan side is. (prospect.org)
  • A consensus has been transformed into a partisan squabble with both sides using bumper sticker talking points as their arguments. (centralmaine.com)
  • In an era of strident polarization - and just in time for the midterm elections - a new study tests an approach for building political consensus and reducing partisan animosity. (stanford.edu)
  • In this era of strident polarization - and just in time for the midterm elections - the new study proposes a straightforward approach for building political consensus and reducing partisan animosity, which research has shown can hinder the government's ability to respond to pressing issues, such as the COVID-19 pandemic. (stanford.edu)
  • 1 2 The Zurich Consensus statement is designed to build on the principles outlined in the original Vienna and Prague documents and to develop further conceptual understanding of this problem using a formal consensus-based approach. (bmj.com)
  • This should all come as something of a shock to people interested in public health, where a formal consensus process has long been the mechanism of interaction between science and policy. (blogspot.com)
  • We are not aware of any formal exercise by which a consensus has been reached or conflicts in the issues related to health policy have been assessed. (who.int)
  • Other areas of consensus identified were: setting up a formal channel of interaction with the private health sector, instituting cost recovery systems in the government sector, setting up a technology assessment commission and bringing accountability into the system. (who.int)
  • In 2020, the authors of the Stanford study surveyed 523 Americans - 52% Democrats, 48% Republicans - and found that more than 85% of them viewed cross-party relations, such as having members of the other party as friends, building consensus, and supporting bipartisan cooperation, as valuable. (stanford.edu)
  • And clearly they didn't mince their words: "Senator Paul's proposal would undermine the decades-long bipartisan consensus on U.S. support for Israel. (eurasiareview.com)
  • But whether there is, as is commonly claimed a "97%" consensus depends crucially on who you include as a scientist, what question you are asking, and how you go about asking it. (blogspot.com)
  • Meanwhile, on the Indian side too, a clear lack of consensus is noticeable. (opendemocracy.net)
  • Not surprisingly, there continues to be a lack of consensus to willfully adopt mask wearing nationwide. (cbssports.com)
  • How should non-scientists respond when told about this consensus? (climatedepot.com)
  • Science achieves a consensus when scientists stop arguing. (skepticalscience.com)
  • In the scientific field of climate studies - which is informed by many different disciplines - the consensus is demonstrated by the number of scientists who have stopped arguing about what is causing climate change - and that's nearly all of them. (skepticalscience.com)
  • 1) Depending on exactly how you measure the expert consensus, it's somewhere between 90% and 100% that agree humans are responsible for climate change , with most of our studies finding 97% consensus among publishing climate scientists. (skepticalscience.com)
  • most people defer to the expert consensus of climate scientists. (skepticalscience.com)
  • One objection against consensus messaging is that scientists should be talking about evidence, rather than consensus. (skepticalscience.com)
  • It generally means that overwhelmingly scientists agree on something, but does not imply that the consensus is total. (millennialstar.org)
  • Bob creates an environment of listening with respect, in which the participants develop a belief that consensus is possible. (managingwholes.com)
  • When it says failing to "present both sides of a political or ideological belief" is conduct unbecoming of a teacher, does that mean we can't teach history anymore? (ohiohouse.gov)
  • Consensus," according to Merriam-Webster, means both "general agreement" and "group solidarity in sentiment and belief. (climatedepot.com)
  • Public perception of the scientific consensus has been found to be a gateway belief, affecting other climate beliefs and attitudes including policy support. (skepticalscience.com)
  • Studies in 2011 and 2013 found that perception of scientific consensus is a gateway belief that has a flow-on effect to a number of other beliefs and attitudes. (skepticalscience.com)
  • Amid the border tensions in Eastern Ladakh, China on Wednesday claimed that Indian side has violated "bilateral agreements and important consensus. (epilogue.in)
  • India's statements reveal the fact that the Indian troops were the first to have illegally crossed the LAC, changed the status quo in the border areas, and violated bilateral agreements and important consensus," Chinese Foreign Ministry spokesperson said. (epilogue.in)
  • China and Afghanistan reached a 'new important consensus' on Tuesday on combating the East Turkistan Islamic Movement as Afghanistan's new president arrived in Beijing for his first state visit since being sworn in. (china.org.cn)
  • The two sides reached a new important consensus on joint efforts in that regard,' Kong said. (china.org.cn)
  • The economic impact, the potential social and legal landscape, even the split between the pro and con sides in the squabble over the initiative on the Nov. 2 ballot to legalize marijuana for recreational use in California - they're all about as clear as smoke from a bong. (sfchronicle.com)
  • Of course we're concentrating only on the Anthropogenic (human-made) side of things. (millennialstar.org)
  • The article suggested that for the first time, empirical evidence was presented that appeared to show a unanimous, scientific consensus on the anthropogenic causes of recent global warming. (populartechnology.net)
  • The consensus format outlined in his learning manuals creates the opportunity for the stakeholders to learn how to seek consensus while resolving conflict. (managingwholes.com)
  • Altmaier added that there was a broad consensus between representatives of the government and associations on the need to reform the EEG. (pv-magazine.com)
  • Though there are significant differences of opinion in how the system should be overhauled, this moment of broad consensus is rare. (neighborhoodlink.com)
  • Expert consensus results on the question of human-caused global warming among the previous studies published by the co-authors of Cook et al. (skepticalscience.com)
  • Expert consensus is a powerful thing. (skepticalscience.com)
  • That's why those who oppose taking action to curb climate change have engaged in a misinformation campaign to deny the existence of the expert consensus. (skepticalscience.com)
  • Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. (bmj.com)
  • The EFL said in a statement: "The need for continued unity across the membership base was fundamental to discussions across all three divisions, and therefore there was a strong consensus that any rescue package must meet the requirements of all 72 Clubs before it can be considered in full. (sky.com)
  • As a Libertarian, not a member of either major party, I have the ability to accept the best ideas of each side and work for consensus and compromise that benefits the state as a whole," he wrote. (reason.com)
  • I see her picking Pennington apart from the outside with her kickboxing en route to a unanimous decision win. (mmanews.com)
  • As of the end of August 2016, the Sell Side indicator was pointing to 12-month total returns of roughly this magnitude over the next 12 months, per that earlier CNBC report. (investopedia.com)
  • So why doesn't climate science have such a consensus process? (blogspot.com)
  • There's a strong correlation between consensus and climate science expertise. (skepticalscience.com)
  • There are several contributors to this "consensus gap", including mainstream media's tendency to give contrarian voices equal weight with the climate science community . (skepticalscience.com)
  • Continued attention to side effects. (medscape.com)
  • The use of these drugs is associated with serious side effects, most prominent is a degeneration of the muscular tissue and debilitating pain that comes with it. (newmediaexplorer.org)
  • Quite apart from the damning information in the articles themselves, you will see that literally hundreds of readers have added accounts of their personal experiences of the side effects of the statin drugs they are taking. (newmediaexplorer.org)
  • Very few primary care physicians are familiar with the association of statin drug use with ALS and most are disinclined to use warnings from websites such as mine about statin drug side effects, saying they are anecdotal. (newmediaexplorer.org)
  • Bitter orange, taken by itself or with stimulants such as caffeine or caffeine -containing herbs, might increase the risk for high blood pressure , fainting , heart attack , stroke , and other serious side effects. (webmd.com)
  • What are the possible side effects of Vicodin ES? (rxlist.com)
  • These are not all the possible side effects of Vicodin ES. (rxlist.com)
  • Call your doctor for medical advice about side effects. (rxlist.com)
  • You may report side effects to FDA at 1-800-FDA-1088. (rxlist.com)
  • Written by the IMF Nurse Leadership Board, made up of experienced specialty oncology nurses, these are the first comprehensive guidelines for managing side effects from lenalidomide, thalidomide, and bortezomib used in the treatment of multiple myeloma. (myeloma.org)
  • To achieve the maximum potential of novel agents, healthcare professionals must adequately address day-to-day details of side effects. (myeloma.org)
  • The IMF believes that nurses play an essential role in managing patient care and recognizes the need for specific information concerning the use of novel antimyeloma agents as well as management of their associated side effects. (myeloma.org)
  • Depending on their severity, the side effects can have a negative impact on patients' medical treatment and quality of life by interrupting or reducing therapy and causing life-threatening complications. (myeloma.org)
  • The novel immunomodulatory drugs lenalidomide and thalidomide and the novel proteasome inhibitor bortezomib can cause gastrointestinal side effects, including constipation, diarrhea, nausea, and vomiting, which can have a deleterious effect on quality of life and interfere with optimal therapy. (myeloma.org)
  • These side effects are manageable with appropriate medical interventions. (myeloma.org)
  • In recognition of the need for specific recommendations on managing key side effects of steroid therapy for patients with myeloma, the International Myeloma Foundation's Nurse Leadership Board developed this consensus statement for the management of steroid-associated side effects to be used by healthcare providers in any medical setting. (myeloma.org)
  • One of the side effects of last month's coronavirus-caused labor agreement between Major League Baseball and its players was the shortening of the annual MLB draft , which will now be somewhere between 5-10 rounds instead of its usual 40. (masslive.com)
  • The consensus report compares the two types of immunotherapy examining side effects, dosing and how effective they are. (allergicliving.com)
  • For subcutaneous therapy for environmental allergies, side effects were found to range from local and mild to systemic. (allergicliving.com)
  • By comparison, the sublingual immunotherapy side effects were generally mild. (allergicliving.com)
  • The most common side effects were local reactions, including itching and minor swelling. (allergicliving.com)
  • These side effects usually only occurred near the beginning of the treatment, and tended to resolve on their own as treatment continued. (allergicliving.com)
  • It has also been suggested that in receptor "unknown cases", it is beneficial to prescribe Tamoxifen, since 75% of breast cancers are likely to be estrogen receptor positive and side effects can be minimized with planned vigilance. (scirp.org)
  • The study looked retrospectively at management with steroids in the first week following presentation with visual acuity and side effects used as outcome measures. (bmj.com)
  • Chinese consensus on management of tyrosine kinase inhibitor-associated side effects in gastrointestinal stromal tumors. (cdc.gov)
  • These drugs can have side effects. (medlineplus.gov)
  • A nonsteroidal immunosuppressive agent should be initially used in conjunction with corticosteroids especially when the long-term risk for steroid side effects is high on the basis of medical comorbidities. (medscape.com)
  • and whether aspirin was stopped due to side effects. (cdc.gov)
  • The guide includes information on TB signs and symptoms, adult dosing, drug-drug interactions, side effects, and patient counseling points. (cdc.gov)
  • Although there is no consensus single treatment paradigm, MG is a treatable neurologic disorder. (medscape.com)
  • Meanwhile, conservatives are more likely to reject the scientific consensus. (skepticalscience.com)
  • In the present review, 31 papers (6% of the sample) explicitly or implicitly reject the consensus. (populartechnology.net)
  • In consensus-based democracies , in contrast, voting is not necessarily used to determine an issue, settle controversies or reach an agreement. (modernghana.com)
  • But factions build consensus and reach agreements amenable to both sides. (modernghana.com)
  • Several other protected areas have been delayed as the member countries failed to reach a consensus. (theguardian.com)
  • We hope the two sides will soon reach a consensus for the larger interest of the people. (dawn.com)
  • Instead, it represents a political block against the People's Alliance that can reach consensus on a common denominator. (duvarenglish.com)
  • Negotiators meeting under the Ad Hoc Working Group on the Durban Platform for Enhanced Action (ADP) here were unable to reach consensus on a stripped-down negotiating text that emerged early Saturday morning as least-developed countries objected to the removal of loss-and-damage provisions. (ecosystemmarketplace.com)
  • In normal years, amateur scouts work hard to build rapport with amateur players and their families in hopes that the sides can reach a financial arrangement when the draft comes. (masslive.com)
  • Over 50 mutually beneficial agreements will be inked during the visit and the two sides will reach new consensus in such areas as energy, high-speed rail and finance. (chinadaily.com.cn)
  • They weren't arguing against the existence of a consensus, but whether we should be communicating the consensus. (skepticalscience.com)
  • As with most legislative efforts around Workers' Compensation, SB 1160 is the product of negotiations involving stakeholders on all sides of the issue. (calaborfed.org)
  • No matter how well founded a scientific consensus, there's someone who thinks it's all hokum. (climatedepot.com)
  • Do we have to trust whatever we're told is based on a scientific consensus unless we can study the science ourselves? (climatedepot.com)
  • But here's a checklist to decide when you can, even should, doubt a scientific "consensus," whatever the subject . (climatedepot.com)
  • Scientific consensus on human-caused global warming as compared to the expertise of the surveyed sample. (skepticalscience.com)
  • The paper found a 97% consensus that humans were causing global warming in relevant scientific papers . (skepticalscience.com)
  • But this is just the latest chapter in over two decades of manufactured doubt on the scientific consensus about climate change . (skepticalscience.com)
  • Consensus messaging recognises the fact that people rely on expert opinion when it comes to complex scientific issues. (skepticalscience.com)
  • Scientific Consensus vs. Manufactured Consensus - Is AGW a Conspiracy? (millennialstar.org)
  • Another anti-AGW argument I hear a lot is that the existing scientific consensus, that global warming is human caused, is "manufactured. (millennialstar.org)
  • It admits that there is indeed a scientific consensus on AGW. (millennialstar.org)
  • A scientific consensus is a code word only used if there is a certain level of consensus. (millennialstar.org)
  • Rather than being a consensus based on scientific merit, it's based on political whim, conspiracy, misinformation, and desire to get lucrative grants. (millennialstar.org)
  • This argument misses one major fact: that all scientific consensus outside of the SUPERB theories falls more or less into this description. (millennialstar.org)
  • During the course of our conversation, when we touched on the subject of the science behind the debate over whether or not GMOs are "safe" (me arguing that there's no scientific consensus ) Enright said, "Then you must not believe in climate change, either. (organicconsumers.org)
  • Harmonization is achieved through the development of ICH guidelines via a process of scientific consensus with regulatory and industry experts working side-by-side. (who.int)
  • That compares to the Wall Street consensus target of $82.20. (247wallst.com)
  • That compares with a much higher consensus target of $126.96. (247wallst.com)
  • 35% of the respondents were on either side of the divide. (who.int)
  • The talks between the two sides have been going on for the last few months including five Lieutenant general-level talks. (epilogue.in)
  • An interesting development took place on Sunday, when after the talks between the two sides, the provincial minister asked the participants about the fate of their protest. (dawn.com)
  • A few days ago news.Bitcoin.com reported on the debate between Bitcoin Cash ( BCH ) developers and community members concerning an idea called 'pre-consensus. (bitcoin.com)
  • I've even heard a story about using this technique for blackmailing the company referenced in the negative article, and pretending to 'switch sides' in the editorial debate on the talk page once the money had been paid (it's DMOZ all over again! (softpanorama.org)
  • Journalists don't feel obligated to report both sides of this debate, just the side in the sphere of consensus. (vox.com)
  • In my last post , I started my sordid tale of my attempt to make sense of the global warming debate and gave two examples, one for each side of the debate, of how both sides use deception to advance their beliefs. (millennialstar.org)
  • Proposals reflect the consensus reached, following two years of meetings and debate, by a CIOMS Working Group representing 12 pharmaceutical companies and 10 regulatory agencies. (who.int)
  • People tend to use so-called democratic tenets to justify their actions even if logical reasoning dictates the use of a human face and consensus to deal with some situations. (modernghana.com)
  • But no one on the Democratic side wants the government to shut down. (wuwm.com)
  • There was no new consensus reached, and nobody would expect that such a complicated issue as democratic reform in Hong Kong could be resolved in one meeting," stated Tong. (voanews.com)
  • This consensus statement focuses on the management of acute severe PH in the paediatric intensive care unit and provides an according treatment algorithm for clinical practice. (bmj.com)
  • India had said on Tuesday that it has taken up the matter of "recent provocative and aggressive actions" with the Chinese side and has urged them to control their frontline troops. (epilogue.in)
  • IMSEAR at SEARO: Consensus and conflicts in health sector reforms in India: a Delphi study. (who.int)
  • Although, there are a lot of people who support Séchet's idea of bringing pre-consensus to the upgrade table, and have bolstered the concept. (bitcoin.com)
  • It's a pretty narrow two-way street with free car parking on both sides that benefits a minority of people. (streetsblog.org)
  • the Buds Live sat naturally in the folds of the concha for people with medium- and large-sized ears without any help, and the wingtips - two sizes come in the box - helped keep them in place inside ears on the tiny side. (theverge.com)
  • While people have differing opinions about social acceptance and political measures, there is often consensus on the technical side. (bfh.ch)
  • Some of our people who have sold themselves to Northern hegemony for filthy lucre will definitely be on the wrong side of history. (sunnewsonline.com)
  • Many people have extreme perceptions of what the other side believes, so it's really about unfreezing those views and getting people to open up to the other side," Santos said. (stanford.edu)
  • Everyone, including the Federal Reserve, is on the opposite side of that trade. (forbes.com)
  • JQ and many others argue one side, but there seem to be plenty of sceptics out there arguing the opposite. (johnquiggin.com)
  • We urge the Indian side to strictly discipline its border troops, stop all provocations, immediately withdraw all personnel who illegally trespassed across the LAC, and stop taking any actions that may escalate tensions or complicate matters," the spokesperson said. (epilogue.in)
  • Indian Army spokesperson had said on Monday that on the night of August 29/30, PLA troops violated the previous consensus arrived at during military and diplomatic engagements during the ongoing standoff in Eastern Ladakh and carried out provocative military movements to change the status quo. (epilogue.in)
  • The talking circle is the centerpiece of the consensus process because it encourages respectful listening. (managingwholes.com)
  • A detailed description of the consensus process is outlined at the end of this document. (bmj.com)
  • Your best bet is to look at the process that produced, defends and transmits the supposed consensus. (climatedepot.com)
  • What if there had been a consensus process of just this sort in place for decades, and nobody noticed. (blogspot.com)
  • Methods The authors developed a framework to classify PSPs by identifying and synthesising existing conceptual frameworks, evaluating the draft framework by asking a group of experts to use it to classify a diverse set of PSPs and revising the framework through an expert-panel consensus process. (bmj.com)
  • This gives both the writers and their readers a false sense of what "mainstream consensus" is. (theatlantic.com)
  • On Wednesday, the EPA is hosting a public meeting on the proposed supplemental biofuel rule in Ypsilanti, Mich., where officials are sure to get an earful from both sides of the issue. (politico.com)
  • Count me on Roberts's side of this one, but I want to take issue with that last "the tribe is too far gone" remark. (coreyrobin.com)
  • Chrome has already addressed the issue and the fix on the browser side is quite simple and elegant. (sans.edu)
  • Another argument against consensus messaging is that public understanding of the climate issue has moved on from fundamental issues such as the consensus. (skepticalscience.com)
  • Is there a meaningful consensus on this kind of issue today either way? (newrepublic.com)
  • This side event, with the support of the Government of Tunisia, seeks to share suggested priority actions from WHO's regional health systems governance team and mobilize political support for institutionalizing participatory governance in health decision-making in countries of the Region. (who.int)
  • The minister said he would lead the government side in the talks along with provincial information minister Saeed Ghani. (dawn.com)
  • Including the Zacks Rank, Zacks Industry Rank, Style Scores, the Price, Consensus & Surprise chart, graphical estimate analysis and how a stocks stacks up to its peers. (zacks.com)
  • The biopharmaceutical company reported ($0.79) earnings per share (EPS) for the quarter, beating the consensus estimate of ($0.86) by $0.07. (etfdailynews.com)
  • The firm had revenue of $18.55 million for the quarter, compared to the consensus estimate of $13.42 million. (etfdailynews.com)
  • The company had revenue of $180.62 million during the quarter, compared to the consensus estimate of $160.90 million. (reporter.am)
  • Madagascar also joined the meeting which aimed at building consensus towards the effective implementation of the SIDS Pooled Procurement Program in line with the Seychelles Declaration of September 2017 wherein Health Ministers expressed interest to implement a Pooled Procurement mechanism. (who.int)
  • The Strategy and Operational Plan for Pooled Procurement developed by WHO, were discussed on the side-lines of the Sixty-Eighth Session of the WHO Regional Committee for Africa held in Dakar in August 2018. (who.int)
  • There is order and disorder in our world today, competition and coordination, conflict and consensus - all going on at the same time. (foreignpolicy.com)
  • Many democracies, whether conservative or liberal, show signs of growing intolerance and the reduced use of consensus in reaching agreements or settling disputes. (modernghana.com)
  • That's the growing consensus from all sides of the political spectrum. (statnews.com)
  • In fact, they mainly reflect the rightwing side of the political spectrum, which currently dominates. (ynetnews.com)
  • What is less well known is that the progression of this muscle wasting side effect may lead to a diagnosis of amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease or motor neurone disease, described as a chronic, progressive, almost invariably fatal neurological disease. (newmediaexplorer.org)
  • This paper presents the U-BIOPRED international consensus on the definition and diagnosis of severe asthma, aligning the latest concepts in adults as well as in children. (bmj.com)
  • The ministry said Indian side is firmly committed to resolve all outstanding issues along the LAC in the Western Sector through peaceful dialogue. (epilogue.in)
  • The 2020 Ghanaian election , for example, revealed a conspicuous lack of resolve to build consensus. (modernghana.com)
  • Inter-Korean tension has been high between the sides since the Lee rolled back a decade of engagement and linked provision of aid to denuclearization steps by the North. (koreatimes.co.kr)
  • Following back-to-back 6-6 weeks for the consensus, here are 14 fresh takes and 11 new consensus picks for Week 8. (bleacherreport.com)
  • There's now only enough consensus to pull it back to 25 percent , not the 28 percent Biden proposed. (prospect.org)
  • With no consensus, the text was sent back to Pulgar-Vidal shortly before 1:30pm. (ecosystemmarketplace.com)
  • Tried to time the departure of fog with the onset of slightly stronger winds on the back side of the surface trough. (noaa.gov)
  • I love the stereo controls on the back side of the spokes, and the back-up camera helps a ton! (viperclub.org)
  • Right away Nchain's chief scientist Craig Wright explained that he thinks pre-consensus is a horrible idea and "no hash goes to this crap. (bitcoin.com)
  • Their advice was sought on the establishment of a consensus 'platform' which could serve as a basis for wideranging discussions with ACP representatives. (nzdl.org)
  • The paint has started to chip and literally fall off the body panels near the rear wheel well edges on both sides of the vehicle! (rangerovers.net)
  • new accumulator and relay fixed the hvac display finally after MANY attempts fixed the broken mounting tabs that where the woood trim attached to the side panels on the center console. (rangerovers.net)
  • Some developers believe pre-consensus could help with block time speeds, zero-confirmation transactions, and consensus in general. (bitcoin.com)
  • What's the general consensus on vipers now anyway? (newschoolers.com)
  • Is there a general consensus that you're reading? (bitrebels.com)
  • The general consensus is that Conor McGregor must finish Donald Cerrone early or he risks being stopped via TKO or submission in the later rounds. (mmanews.com)
  • This coalition of interests, in a sense, mirrors the consensus-based approach of Javanese society. (livemint.com)
  • A consensus based approach would have resulted in a far more peaceful acceptance of the election results and avoided the chaotic scenes in parliament. (modernghana.com)
  • Leadership is more moderate in consensus democracy than it is in pendulum democracy, where power can swing from one side to another. (modernghana.com)