Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Kinetics: The rate dynamics in chemical or physical systems.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Side-Population Cells: A group of cells identified on FLOW CYTOMETRY profiles as distinct from the main group of cells by their ability to extrude the fluorescent dye Hoechst 33342, often a characteristic property of less differentiated progenitor and STEM CELLS.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Static Electricity: The accumulation of an electric charge on a objectCattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Bacterial Proteins: Proteins found in any species of bacterium.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.Histidine: An essential amino acid that is required for the production of HISTAMINE.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Lysine: An essential amino acid. It is often added to animal feed.Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Facial Asymmetry: Congenital or acquired asymmetry of the face.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Hemiplegia: Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Oligopeptides: Peptides composed of between two and twelve amino acids.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.Rotation: Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Arginine: An essential amino acid that is physiologically active in the L-form.Peptoids: Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Cholesterol Side-Chain Cleavage Enzyme: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.Pain, Postoperative: Pain during the period after surgery.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Cadaver: A dead body, usually a human body.Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Posture: The position or attitude of the body.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Molecular Dynamics Simulation: A computer simulation developed to study the motion of molecules over a period of time.Dimerization: The process by which two molecules of the same chemical composition form a condensation product or polymer.Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Biophysics: The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Automobiles: A usually four-wheeled automotive vehicle designed for passenger transportation and commonly propelled by an internal-combustion engine using a volatile fuel. (Webster, 1973)Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Xenopus laevis: The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Protein Structure, Quaternary: The characteristic 3-dimensional shape and arrangement of multimeric proteins (aggregates of more than one polypeptide chain).Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Body Patterning: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Ion Channel Gating: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Behavior, Animal: The observable response an animal makes to any situation.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Cell Line, Tumor: A cell line derived from cultured tumor cells.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Biophysical Phenomena: The physical characteristics and processes of biological systems.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Models, Structural: A representation, generally small in scale, to show the structure, construction, or appearance of something. (From Random House Unabridged Dictionary, 2d ed)Mastication: The act and process of chewing and grinding food in the mouth.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Equipment Design: Methods of creating machines and devices.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Hypertrichosis: Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.Spectrophotometry: The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Paresis: A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). "General paresis" and "general paralysis" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Crystallography: The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Side effects[edit]. Further information: Beta blocker § Adverse effects. The most common side effect is eye irritation felt as ... If the substance reaches the nasal mucosa via the tear duct, it can be absorbed into the bloodstream and cause systemic side ... InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 ... It has an elimination half-life of six hours and is mainly excreted via the kidney.[1][2] ...
Usage and side effects orally as laxative[edit]. Liquid paraffin is considered to have a limited usefulness as an occasional ... Efficacy of liquid paraffin is suggested by 2016 Cochrane review.[1] It might interfere with the absorption of fat-soluble ... 27 (1 Pt 2): 75-81. doi:10.1006/rtph.1997.1109. ISSN 1096-0295. PMID 9618325.. ...
In Germany, "Mini, mini, mini" was released as an a-side, backed with "Et moi, et moi, et moi".[6] For the Italian market, an ... In the UK and The Netherlands, it was released as a 2-track 7" single, with "Mini, mini, mini" as the b-side. ... Wolfsohn then asked Dutronc if he would be interested in recording his own version.[1] ... 1] Wolfsohn wanted to better Fechner's success with the hippy-influenced singer-songwriter Antoine. He asked Jacques Dutronc, ...
When unfolded, a whole side of the insert features a lengthy article printed entirely in Dutch. It is a review of a Tonight's ... On the front of the insert is a letter to a character called "Waterface"; scratched into the run-out grooves on side one is the ... ISBN 1-932958-61-4. OCLC 70672814. Retrieved 26 February 2006.. *^ a b c McDonough, Jimmy. Shakey: Neil Young's Biography. New ... It was recorded in 1973 (most of it on a single day, August 26[1]), its release delayed for two years. It peaked at #25 on the ...
Side effects and complications[edit]. Abdominal X-ray showing a double J stent to relieve colics from kidney stones (red arrows ... ISBN 1-84184-387-3 Martin Dunitz. *Minimally Invasive Ureteric Stent RetrievalTaylor WN, McDougall IT J UrolVol 168,2020-2013, ...
Common side effects include anxiety, headache, sleepiness, cough, and nausea.[2] Serious side effects may include kidney ... Side effects[edit]. Further information: Fluoride poisoning. The consensus is that the use of methoxyflurane should be ... 28 (1): 57-63. doi:10.1136/emj.2009.078717. PMID 20466829.. *^ a b c Major V, Rosen M, Mushin WW (1966). "Methoxyflurane as an ... 22 (1): 143. doi:10.1097/00000542-196101000-00044.. *^ Millar RA, Morris ME (1961). "A study of methoxyflurane anaesthesia". ...
Side effects[edit]. After long-term use for treating chronic conditions, tolerance may develop in patients, reducing its ... Common side effects include headache, lightheadedness with standing, and blurred vision.[1] Severe side effects include low ... InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1 Y ... It is used for angina, in addition to other medications for congestive heart failure, and for esophageal spasms.[1] ...
354-. ISBN 978-2-06-718220-2. Gérards, Emile (1908). Paris Souterrain (in French). Sides. ISBN 2840220024. ... 118-. ISBN 978-1-285-53155-7. "Urban legends and black masses: The eerie secrets of the Paris Catacombs". thejournal.ie. ... 147-. ISBN 978-2-7108-0739-1. Donald R. Prothero (13 July 2006). After the Dinosaurs: The Age of Mammals. Indiana University ... Michelin Travel & Lifestyle (1 April 2011). Michelin Green Guide Paris. Michelin Travel & Lifestyle. pp. ...
A common constant c may be added to or subtracted from both sides of an inequality:. *For any real numbers a, b, c *If a ≤ b, ... If x, y , 0 and 0 , p , 1, then. x. p. +. y. p. ,. (. x. +. y. ). p. .. {\displaystyle x^{p}+y^{p},(x+y)^{p}.}. *If x, y, z , 0 ... 1. ,. x. 2. ,. …. ,. x. n. ). T. {\displaystyle x=\left(x_{1},x_{2},\ldots ,x_{n}\right)^{\mathsf {T}}}. and y. =. (. y. 1. ,. ... 1. a. 2. +. a. 2. a. 3. +. ⋯. +. a. n. a. 1. ,. 1. {\displaystyle a_{1}^{a_{2}}+a_{2}^{a_{3}}+\cdots +a_{n}^{a_{1}},1}. (result ...
Side two[edit]. *Medley - 19:56 *"New York Mining Disaster 1941" (Barry Gibb/Robin Gibb) - 2:16 ... Side one[edit]. *"I've Gotta Get a Message to You" - 4:02 ... Side one[edit]. *"You Should Be Dancing" - 9:22. *"Boogie Child ... Side two[edit]. *"Wind of Change" (Barry Gibb, Robin Gibb) - 4:42 ... 1 in New Zealand and No. 2 in Spain, and sold 4.6 million ...
On the other side of the levee, they were yelling 'Shoot that big [soldier]!' while Jack was daring the whole gang to come up ... Three Sides". The Atlantic. Retrieved 15 April 2017. "Union Regimental Histories". The Civil War Archive. Archived from the ... ISBN 1-7803-9234-6. Thomas, Lorenzo (April 14, 1863). Special Orders No. 9. U.S. War Department. Barnickel, Linda. "Milliken's ... ISBN 0-7864-1697-1. Smith, John David (2002). Black Soldiers in Blue: African American Troops in the Civil War Era. University ...
Hampton, Sides. Hellhound on His Trail: The Stalking of Martin Luther King, Jr. and the International Hunt for His Assassin. ... Both sides exchanged gunfire, and a police officer was killed. The veterans retreated to Fort Pickering, where they were ... 31 (1): 3-19. doi:10.1177/002193470003100101. ISSN 0021-9347. JSTOR 2645929. Tennessee State Library and Archives (2011). " ... Tennessee: 2010 Summary Population and Housing Characteristics, US Census Bureau, CPH-1-44 U.S. Census Bureau. "Memphis (city) ...
doi:10.1111/j.1460-2466.2010.01497.x. Lawrence, Eric; Sides, John; Farrell, Henry (2010). "Self-Segregation or Deliberation? ... ISBN 978-1-4522-9026-3. Scheufele, D.A; Nisbet, M. C. (2012). "Commentary-Online News and the Demise of Political Disagreement ... ISBN 978-1-4522-6545-2. Klapper, Joseph T. (1960). The effects of mass communication. Free Press. p. 19. LCCN 60014402. Kim, ... 2 (1): 464-493. doi:10.1111/j.1751-9004.2007.00060.x. Frey, D (1986). "Recent research on selective exposure to information". ...
Pitchfork Media felt that the lyrical side of the album lacked depth ("and there is absolutely nothing wrong with that"), yet ... Soul Sides. Retrieved 2014-02-23. Portugal, Christopher (2011-03-30). "Acid Raindrops Design Contest". Piecelock70. Retrieved ...
"Bee-Sides". yessaid.com. Archived from the original on 2009-06-25. "Bee-Sides". yessaid.com. "Official Charts > Tori Amos". The ... The title More Pink may be misleading, as many of the B-sides on the disc did not come from Under the Pink singles but in fact ... Notes The original track listing included the B-side "Honey", which was left off the album at the last minute. Amos has since ... In My Head" which was originally featured as a B-side to the UK single of "Crucify". Under the Pink produced four singles. " ...
"Supranational sides". nifootball.blogspot.co.uk. 9 December 2006. Retrieved 20 October 2014. "Cap could be Webb's reward". The ... He became the youngest ever scorer for the Berkshire side. In July 1982 he transferred to Portsmouth for £87,500. At Fratton ... Webb also played for Reading, Swindon Town, Grimsby Town, Aldershot Town and Hong Kong side Instant-Dict. Webb joined Reading ... from June to December 1997 he was player-coach of Southern League Southern Division side Weymouth, but quit after just 70 days ...
The Wall Street Journal; Book Review: 'In the Kingdom of Ice' by Hampton Sides. Daily Mail; Russian bid to raise wreck of US ... Check date values in: ,access-date= (help) "Hampton Sides: "In the Kingdom of Ice"; The Diane Rehm Show". The Diane Rehm Show; ... Check date values in: ,access-date= (help) "Book Review: 'In the Kingdom of Ice' by Hampton Sides; The Wall Street Journal". ... Hampton Sides: "In the Kingdom of Ice". Weekend Edition (NPR); In 1879, Explorers Set Sail To Solve Arctic Mystery, Once And ...
In 2010 he was commissioned by Ransom Productions to write one part of a double bill entitled Both sides alongside David ... Both Sides". Irishtheatremagazine.ie. Archived from the original on 5 June 2013. Retrieved 1 March 2013. ... 1 best sellers list. His first published volume of poetry was Muskerry (1991, Dedalus Press) followed by Secret Societies (1997 ... Retrieved 1 March 2013. "Making sense of a son's death". 18 October 2012. "Kicking the Black Mamba". Newsletter. Retrieved 18 ...
See the YouTube clip, MP Joyce Murray on the Black Rod of B.C.. "2014 Speech from the Throne in Photos". BC b-sides. Province ...
Delaforce, Patrick (1995). Monty's Iron Sides. Stroud, Gloucestershire: Allan Sutton Publishing. p. 206. ISBN 0-7509-0781-9. ... 1/10th (Scottish) Battalion, King's (Liverpool Regiment) (from November 1914 to January 1916) 12th (Service) Battalion, West ...
ISBN 978-0-520-24990-5. Sides, Josh (2003). L.A. City Limits: African American Los Angeles from the Great Depression to the ... ISBN 978-0-520-23841-1. Rasmussen, Cecilia (1996-11-29). "City Smart". Los Angeles Times. p. B.2. Retrieved 2009-12-01. "The ... ISBN 978-0-8018-8208-1. U.S. Geological Survey Geographic Names Information System: Parque Culiacan Bruce's Beach The History ...
Sides, Hampton (2014). In the Kingdom of Ice: The Grand and Terrible Polar Voyage of the U.S.S. Jeannette. Doubleday. Headland ...
Nyhan, Brendan; Sides, John (2011). "How Political Science can help journalism (and still let journalists be journalists)". The ... Nyhan, Brendan; Sides, John (2011). "How Political Science can help Journalism (and still let journalists be journalists)". The ... Embedded journalism can also be biased because it is one sided. Information reported has been collected from the area the ... Brendan Nyhan and John Sides argue that "Political journalists who report on politics are frequently unfamiliar with political ...
... at AllMusic "MIRACLES, MOTOWN, AND MEMORIES". Soul-Sides.com. Retrieved 25 November 2016. "http://www. ... Dusty Groove album review [1] Hi... We're the Miracles at AllMusic Amazon.com album reviews- Hi...We're The Miracles Catalog ... 1 on the Billboard R&B singles chart and #2 on the pop singles chart (#1 Pop, Cashbox). "Shop Around" was the first R&B #1 ...
222-226 Sides 2014, pp. 354-360 Sides 2014, pp. 364-372 Sides 2014, pp. 386-396 Fleming 2002, p. 239 Sides, Hampton (August 1, ... 98 Sides 2014, pp. 161-195 Guttridge 1988, pp. 172-174 Sides 2014, pp. 226-229 Sides 2014, p. 272 De Long 1884, p. 679 Fleming ... 31-32 Sides 2014, p. 81 Guttridge 1988, pp. 42-43 Fleming 2002, p. 196 Sides 2014, pp. 91-93, 105 De Long & Newcomb 1882, p. 23 ... Sides 2014, pp. 86-87 "The Trent Affair". U.S. Department of State. Retrieved 10 August 2015. Coleman 2007, pp. 170-171 Fleming ...
ISBN 0-87687-500-2. Sides, Hampton, Blood and Thunder, Doubleday, 2006. ISBN 0-385-50777-1. Spicer, Edward, Cycles of Conquest ... ISBN 0-87687-500-2. Sides, Hampton (2006). Blood and Thunder. Doubleday. ISBN 0-385-50777-1. Hughes, J, Doniphan's Expedition. ... 5 said the prisoners and property taken by both sides were to be restored. After the treaty was signed, gifts were exchanged as ... that Article 3 said free trade was guaranteed by both sides, with protection of any molestation and Articles 4 & ...
Chklovskii DB (2004). "Synaptic connectivity and neuronal morphology: two sides of the same coin". Neuron. 43 (5): 609-17. doi: ... ISBN 0-262-55060-1.. *^ Machens CK, Romo R, Brody CD (2005). "Flexible control of mutual inhibition: a neural model of two- ... 1] The term mathematical neuroscience is also used sometimes, to stress the quantitative nature of the field.[13] ...
ISBN 0-85420-999-9. Delaforce, Patrick (1995). Monty's Iron Sides. Stroud: Alan Sutton. ISBN 0-7509-0781-9. Forty, George (1998 ... ISBN 1-85117-009-X. James, Brigadier E.A. (1978). British Regiments 1914-18. London: Samson Books Limited. ISBN 0-906304-03-2. ... TA units were reactivated on 1 January 1947, though no personnel were assigned until commanding officers and permanent staff ... The 3rd Reconnaissance Regiment was reconstituted on 1 January 1947, converted to infantry with its former title (8th Battalion ...
The first step in human ovarian steroidogenesis is catalyzed by cholesterol side-chain cleavage cytochrome P450 (CYP11A1) ... The first step in human ovarian steroidogenesis is catalyzed by cholesterol side-chain cleavage cytochrome P450 (CYP11A1) ... The first step in human ovarian steroidogenesis is catalyzed by cholesterol side-chain cleavage cytochrome P450 (CYP11A1) ... The first step in human ovarian steroidogenesis is catalyzed by cholesterol side-chain cleavage cytochrome P450 (CYP11A1) ...
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the ... Cholesterol Side-Chain Cleavage Enzyme (CYP11A1). Subscribe to New Research on Cholesterol Side-Chain Cleavage Enzyme ... A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the ... 12/01/1991 - "Normal genes for the cholesterol side chain cleavage enzyme, P450scc, in congenital lipoid adrenal hyperplasia." ...
In the peptoids discussed here, chiral centres are present in the side chains thus making them suitable for chiroptical ... Peptoids are analogues of α-peptides where the backbone is achiral due to the proteinogenic side chains being relocated from ... Peptoids are analogues of α-peptides where the backbone is achiral due to the proteinogenic side chains being relocated from ... This enabled the contribution from the side chains to the peptoid backbone conformation to be assessed. This was further probed ...
South side is my favorite comedy show of 2019. Does well depicting the south side of Chicago while providing social commentary ... South Side is a funny look at people who love their neighborhood but know its going to keep them down if they dont do ... South Side barrages you with so many jokes, and in so short a time, that after a few minutes of watching, youll feel drunk. ... South Side is the more conventional of the two, with all the rapid-fire jokes and zany digressions of a Tina Fey joint. ...
Side effects, warnings and precautions, dosing, storage, and pregnancy and breastfeeding are provided. ... Consumer information about the prescription drug vitamin K-1, phytonadione (Mephyton) used to treat hypoprothrombinemia and ... What are the side effects of vitamin k-injection?. Serious hypersensitivity reactions, including anaphylactoid reactions and ... You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1- ...
‎From backstage controversies to mysterious deaths and unsolved homicides, this series explores the darkest stories from the golden age of professional wrestling, and tries to find truth at the intersection of fantasy and reality.
... includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug ... Consumer information about the medication alpha-1 proteinase inhibitor (Prolastin-C), ... What are the side effects of alpha-1-proteinase inhibitor-injection?. *What is the dosage for alpha-1-proteinase inhibitor- ... What are the side effects of alpha-1-proteinase inhibitor-injection?. *What is the dosage for alpha-1-proteinase inhibitor- ...
England has secured top spot in the Reliance ICC Test Championship table at the 1 April cut-off date, after the first Test ... each but Mahendra Singh Dhonis side is ranked above Michael Clarkes side when the ratings are calculated beyond the decimal ... For the next three years, a total of US$3.8m will be distributed in prize money with the side topping the table at the 1 April ... with the Proteas having a real chance to finish as the number-one ranked side at the 1 April cut-off date.. While the weather ...
You have a soft side...its just inebriated at the moment.... Des edit on 1-5-2012 by Destinyone because: (no reason given). ... yep you got me, i guess im gullible in thinking that you actually have a soft side silly me ... L i clicked the link thinking "Bonchos soft side, hmmm... betcha its also marinated. ... Political Mud-Pit • 1 • : EternalSolace * TH3WH17ERABB17 -Q- Questions. White House Insiders postings -PART- -14-. Political ...
These dye-extruding cells have been called side population cells because they locate in the side of dye-retaining cells after ... Challen GA, Little MH (2006) A side order of stem cells: the SP phenotype. Stem Cells 24:3-12PubMedCrossRefGoogle Scholar ... Oyama T, Nagai T, Wada H et al (2007) Cardiac side population cells have a potential to migrate and differentiate into ... Cardiac progenitor cells Cardiac stem cells Side population (SP) Hoechst 33342 Stem cell antigen-1 (Sca-1) ...
Approximately 1 1/2 years ago, I received an injection of Kenalog ( i do not know the concentration of the solution) that was ... Kenalog Injection - side effects aaron007 Approximately 1 1/2 years ago, I received an injection of Kenalog ( i do not know the ... As for the darkening, I suspect that you are describing a shadow cast by the sides of the dimple. Its at least possible that ... Is loss of sebaceous gland activity a known side effect of kenalog injection ? if so, how long do you think this should last or ...
Yesterday we spoke with The New Yorkerâ s Jane Mayer about "The Dark Side," her new book exploring the White Houseâ s move to ...
Easy-to-read patient leaflet for Allerhist-1. Includes indications, proper use, special instructions, precautions, and possible ... All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor ... Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also ... These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. ...
Includes common and rare side effects information for consumers and healthcare professionals. ... Learn about the potential side effects of Hydroserpine 1 (hydrochlorothiazide/reserpine). ... Cardiovascular side effects include hypotension in 8% and bradycardia (and rare cases of syncope with bradycardia) in 3% of ... Hematologic side effects are rare. Cases of immune-complex hemolytic anemia, aplastic anemia, and thrombocytopenia have been ...
1 Vital Side Gig for Auditioning Actors. By Briana Rodriguez , Posted Sept. 24, 2015, 11 a.m. ...
Read the side effects of Interferon Alfacon-1 as described in the medical literature. In case of any doubt consult your doctor ... Side effects of Drugs. Side effect(s) of Interferon Alfacon-1 Read the side effects of Interferon Alfacon-1 as described in the ... Interferon Alfacon-1 - Information. Interferon Alfacon-1 is an interferon, prescribed for hepatitis C virus ...
Bucket of B-Sides Vol. 1 is a compilation album released in 2005 by the independent hip hop label Definitive Jux. It featured ... tracks which had appeared as B-sides on some of the labels previously issued singles and EPs. "Fondle Em Fossils (El-P remix ...
... side effects and safety, interactions, pictures, warnings and user ratings. ... Find patient medical information for Vagistat-1 Vaginal on WebMD including its uses, ... Side Effects. Side Effects. Headache or vaginal/urethral burning/itching/pain may occur. If any of these effects persist or ... Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/ ...
Since then, slowly he has stopped sweating COMPLETELY on the right side & just recently his head down to his left nipple. ... ... Basically, he sweats NOWHERE except the left side of his body from his nipple down, and the sweat pours offf of him just ... Since then, slowly he has stopped sweating COMPLETELY on the right side & just recently his head down to his left nipple. ...
... side effects, drug interactions, warnings, patient labeling, reviews, and related medications. ... Learn about Vagistat-1 (Tioconazole) may treat, uses, dosage, ... SIDE EFFECTS Drug Description Indications & Dosage Side Effects ... Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that ... Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an ...
... side effects and safety, interactions, pictures, warnings and user ratings. ... Find patient medical information for Dailyhist-D 1 Oral on WebMD including its uses, ... Side Effects. Side Effects. Drowsiness, dizziness, headache, constipation, stomach upset, blurred vision, trouble walking/ ... Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/ ...
Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked ... What side effects may I notice from receiving this medicine?. Open Side effects that you should report to your doctor or health ... weakness or numbness in the arms or legs, especially on one side of the body. -yellowing of the eyes or skin. Side effects that ... sudden loss of coordination, especially on one side of the body. -speech problems. -symptoms of vaginal infection like itching ...
Hello, 30 year old Black Woman - Having right side facial pain in ear, jaw, upp teeth, below eye and facial swelling. Severity ... MRI W/ contrast shows inflamation (non-cancer)of the Vidian Canal Nerve right side. Everything else looks "good" Neuro surgeon ... Can anaemia cause death? 5 tips on better communication for people with hearing loss New chlamydia test offers rapid results 1 ...
In 1874, there were four banks in the town, the others being the Midland, also on Churchyard Side; the Savings Bank on Welsh ... located on the corner of Churchyard Side and Pepper Street (SJ6511952369), opposite St Marys Church. Built in 1864-66 to a ... 1-3 Churchyard Side was built in 1864-66 to a design by Alfred Waterhouse as the Nantwich branch of the Manchester and ... 1-3 Churchyard Side is two-storey Victorian Gothic building in red brick with blue brick decoration and sandstone dressings, ...
Details about Titanium Swimming Pool Heat Exchanger 85kBtu Same Side 1 + 3/4FPT Mariculture. ... Pool & Spa Heat Exchanger 85kBtu SS316L Same Side 1" + 3/4"FPT Pool Heating ... Stainless Steel Pool Heat Exchanger 85kBtu Opposite Side 1" + 3/4"FPT Snow Melt ... Titanium Swimming Pool Heat Exchanger 85kBtu Same Side 1 + 3/4FPT Mariculture ...
  • After ovulation there is a down-regulation in steroidogenic factor-1, which is associated with an up-regulation of LRH-1 expression. (elsevier.com)
  • We propose that LRH-1 could be the major transcription factor for the post-ovulatory surge in human ovarian steroidogenesis. (elsevier.com)
  • Dosage-sensitive sex-reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene-1 inhibited LRH-1 stimulated CYP11A1 expression, and that was not overcome by the presence of PKA agonist. (elsevier.com)
  • In this study, we examined the role of LRH-1 in the regulation of human granulosa cell CYP11A1 expression. (elsevier.com)
  • Cotransfection of human granulosa cell tumor cells with CYP11A1 promoter and LRH-1 expression vector resulted in a significant increase in CYP11A1 expression. (elsevier.com)
  • We conclude that CYP11A1 expression in human granulosa cells is regulated by LRH-1. (elsevier.com)
  • Several police units closed down part of South Presa Street after a fatal shooting was reported on Thursday, Feb. 1, 2018. (mysanantonio.com)
  • Nervous system side effects commonly associated with reserpine include sedation, lethargy (different from the psychiatric syndrome of depression), drowsiness, weakness, vertigo , insomnia , or headache in approximately 1% to 5% of patients. (drugs.com)
  • Common side effects of Catapres-TTS-1 include dry mouth, fatigue (feeling tired), and headache. (rxwiki.com)
  • That experience directly informs "Sherman's Showcase," but it can also be seen in "South Side," whose scenes and episodes don't build (at least not in any intricate or surprising way) but skip along from joke to joke, verbally and visually. (rottentomatoes.com)
  • VAGISTAT-1 (tioconazole 6.5%) is formulated in a base of white, soft paraffin and aluminum magnesium silicate with butylated hydroxyanisole (BHA) added as a preservative. (rxlist.com)
  • Lee J, Kim M, Kang B, Jo SB, Kim HG, Shin J, Cho K (2014) Side-chain engineering for fine-tuning of energy levels and nanoscale morphology in polymer solar cells. (springer.com)
  • Ye L, Zhang S, Zhao W, YaoH Hou J (2014) Highly efficient 2D-conjugated benzodithiophene-based photovoltaic polymer with linear alkylthio side chain. (springer.com)
  • Recommended by plastic surgeons and dermatologists, Scar Fx Silicone Scar Sheet - 1' x 12' (w/Self Adhesive Side) is medically proven in helping reduce the appearance, size, height, thickness, and color of scars for all skin types and color. (makemeheal.com)
  • Another way to identify putative CSCs, the side population (SP) technique, which identified a small population of cells as a Hoechst low side population by dual-wavelength flow cytometry, has been developed and applied for the identification of CSCs in various cancers including leukemia, breast cancer and so on. (aacrjournals.org)
  • Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. (uzh.ch)
  • Catapres-TTS-1 may worsen pre-existing heart conduction abnormalities, especially if you are taking other drugs similar to the way Catapres-TTS-1 works. (rxwiki.com)
  • What conditions does Vagistat-1 Ointment With Prefilled Applicator treat? (webmd.com)
  • List Vagistat-1 Ointment With Prefilled Applicator side effects by likelihood and severity. (webmd.com)
  • Each applicator-full of VAGISTAT-1 (tioconazole) provides approximately 4.6 grams of ointment containing 300 mg of tioconazole. (rxlist.com)
  • Each applicator-full will deliver approximately 4.6 grams of VAGISTAT-1 containing 65 mg of tioconazole per gram of ointment . (rxlist.com)
  • In this chapter, we describe the methodology for the isolation of cardiac SP cells and Sca-1 positive cells. (springer.com)
  • South Side is the more conventional of the two, with all the rapid-fire jokes and zany digressions of a Tina Fey joint. (rottentomatoes.com)
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Allerhist-1 (clemastine tablets) affects you. (drugs.com)
  • 2) I have been getting headaches in the afternoon - I have to get up 3 times during the night to urinate - and I have been suffering from insomnia - should I be concerned or are these typical side affects during the first month of beginning Combivir? (thebody.com)
  • I think this is what I have- it is called torticollis and it means that a muscle in the neck is tightening with limits movement of the head to the side that it affects. (circleofmoms.com)
  • In these "pre-workout" formulas, 1,3-dimethylamylamine is added to provide a boost of energy and concentration that enables users to press through the most grueling of workouts. (ultimatefatburner.com)
  • If you have an allergy to clemastine or any other part of Allerhist-1 (clemastine tablets). (drugs.com)
  • Taking Allerhist-1 (clemastine tablets) within 14 days of those drugs can cause very bad high blood pressure. (drugs.com)
  • Do not breast-feed while you take Allerhist-1 (clemastine tablets). (drugs.com)
  • Do not give Allerhist-1 (clemastine tablets) to a premature baby or a newborn. (drugs.com)
  • You must check to make sure that it is safe for you to take Allerhist-1 (clemastine tablets) with all of your drugs and health problems. (drugs.com)
  • Tell all of your health care providers that you take Allerhist-1 (clemastine tablets). (drugs.com)
  • Do not use Allerhist-1 (clemastine tablets) to treat asthma . (drugs.com)
  • If you are 60 or older, use Allerhist-1 (clemastine tablets) with care. (drugs.com)
  • You will need to talk about the benefits and risks of using Allerhist-1 (clemastine tablets) while you are pregnant. (drugs.com)
  • Use Allerhist-1 (clemastine tablets) as ordered by your doctor. (drugs.com)
  • If you take Allerhist-1 (clemastine tablets) on a regular basis, take a missed dose as soon as you think about it. (drugs.com)
  • Many times Allerhist-1 (clemastine tablets) is taken on an as needed basis. (drugs.com)
  • administer 1 mg/dose/day intramuscularly (into the muscle) or subcutaneously (into the fatty tissue). (medicinenet.com)
  • The recommended dose of alpha-1 proteinase inhibitor is 60 mg/kg administered into the vein (intravenously) once weekly. (medicinenet.com)
  • VAGISTAT-1 (tioconazole) has been found to be effective as a single- dose treatment for vulvovaginal candidiasis. (rxlist.com)
  • For the prevention of bleeding due to stress ulcers in people who are critically ill, the recommended adult dose of the liquid is 1 g (5 mL) 4 to 6 times daily. (canada.com)
  • Bucket of B-Sides Vol. 1 is a compilation album released in 2005 by the independent hip hop label Definitive Jux. (wikipedia.org)
  • Side effects can be mild or severe, temporary or permanent. (canada.com)
  • Contact your doctor if you experience these side effects and they are severe or bothersome. (canada.com)
  • The prevalence and severity of periodontal diseases are increased in individuals with both type 1 and type 2 forms of diabetes especially severe uncontrolled type 1 diabetes. (amazonaws.com)
  • Approximately 1 1/2 years ago, I received an injection of Kenalog ( i do not know the concentration of the solution) that was meant to alleviate post-surgical scarring in the chin area. (medhelp.org)
  • Other respiratory system side effects are rare, and include approximately 30 case reports of acute noncardiogenic pulmonary edema associated with HCTZ and less than 10 case reports of bronchospasm associated with reserpine. (drugs.com)
  • Burning and itching were the most frequent side effects occurring in approximately 6% and 5% of the patients, respectively. (rxlist.com)
  • Administration of VAGISTAT-1 (tioconazole) just prior to bedtime may be preferred. (rxlist.com)
  • Type 1 or Insulin Dependent diabetes - with 2% incidence, sudden onset of diabetes begins prior to 25 years of age. (amazonaws.com)
  • Type 2 or Non-insulin Dependent diabetes -mainly affecting obese middle-aged people, Type 2 diabetes is characterized by slow onset and includes any other type of the type 1 symptoms. (amazonaws.com)
  • Type 1 diabetes is characterized by the sudden appearance of thirst, frequent urination, hunger, and weight loss. (amazonaws.com)
  • A total of 454 patients were included, 199 (43.8%) with a 1.1.1 bifurcation and 255 patients (56.2%) with any other type of bifurcation. (ahajournals.org)
  • Amido-substituted cyclic derivatives were synthesized by classical organic synthetic reactions in order to study the influence of the type and length of the amide side chain as well as its position on the tetracyclic skeleton on biological activity. (rsc.org)
  • A series of D-A-D type small molecules containing thiophene and benzo[1,2,hiadiazole (BT) as electron-donating and electron-accepting units, respectively, were synthesized using palladium-catalyzed Suzuki coupling reactions. (springer.com)
  • Room on each side for 16 letters on sheep size (tag size: 1-1/4 L x 3/8 W, 8 letters per line), or three big numbers. (enasco.com)
  • Nothing you see him ciproxina xr 500mg side effects not be obvious erection size do? (naschip.org)
  • These are not all of the side effects that may occur. (drugs.com)
  • Other, less serious side effects may be more likely to occur. (rxlist.com)
  • Side effects other than those listed here may also occur. (rxlist.com)
  • Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e.g., hallucinations , irritability, nervousness, confusion), ringing in the ears , trouble urinating. (webmd.com)
  • Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, fast/irregular heartbeat, seizure . (webmd.com)
  • Due to the lack of conclusive safety data, alpha-1 proteinase inhibitor should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. (medicinenet.com)
  • Alpha-1 proteinase inhibitor is classified as FDA pregnancy risk category C. (medicinenet.com)
  • Furthermore, because the expression of SF-1 mRNA precedes hormonal/cAMP induction of P450scc mRNA and is not regulated in vitro by cAMP, the functional role of SF-1 in transcriptional regulation of the P450scc gene, including its induction by cAMP, is not entirely clear and is probably dependent on other factors and/or the modification (phosphorylation? (nih.gov)
  • Many girls and women using hormonal contraception will have several side-effects at the same time. (livingnow.com.au)
  • This test can reliably distinguish between herpes 1 and herpes 2 antibodies. (dads-space.com)
  • As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). (uzh.ch)
  • Anti-PD-1 antibodies can induce a plethora of irAEs. (uzh.ch)
  • 1-3 Churchyard Side is a grade-II-listed Victorian Gothic building in Nantwich, Cheshire, England, located on the corner of Churchyard Side and Pepper Street (SJ6511952369), opposite St Mary's Church. (wikipedia.org)
  • Bar magnets side by side, opposite polarity, repulsion at null point? (thenakedscientists.com)
  • Bar magnets side by side with opposite polarity will attract and attach to one another if they get close enough to one another. (thenakedscientists.com)
  • The magnetic flux of the magnets flows in opposite direction along the sides, and there is a 'null point' in the overall field. (thenakedscientists.com)
  • Womens sizing lace up bootie * 5 inch heel - Front lace up * Ankle boots - Full side zipper * Pointed toe - Matte black boots. (realsimple.com)
  • Bookmark, silver-plated steel, 5-1/8 x 9/16 inch with (3) 1mm holes, 1mm thick. (firemountaingems.com)
  • This strategy has never been specifically evaluated in more complex lesions involving the two side branches (medina 1.1.1). (ahajournals.org)
  • In this observational study, patients with Medina 1.1.1 LM lesions have worse baseline characteristics and clinical outcome compared to other lesion types. (ahajournals.org)
  • Call your doctor for medical advice about side effects. (drugs.com)
  • Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. (canada.com)
  • Langer Biomechanics PPT Sheets 1/4" Sheet abraded on one side : For use as padding, lining or make-it-yourself components, the PPT sheet is comfortable, medical-grade protection that won't flatten or bottom out. (egeneralmedical.com)
  • Matsuura K, Nagai T, Nishigaki N et al (2004) Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. (springer.com)
  • Pfister OF, Mouquet M, Jain R et al (2005) CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. (springer.com)
  • Fashioned with soft ruched detail and a functional side zipper, this boot features a microfiber footbed for all day long comfort. (realsimple.com)
  • Metabolic side effects are commonly associated with hydrochlorothiazide (HCTZ), especially when doses greater than 50 mg per day are used. (drugs.com)