Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Kinetics: The rate dynamics in chemical or physical systems.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Side-Population Cells: A group of cells identified on FLOW CYTOMETRY profiles as distinct from the main group of cells by their ability to extrude the fluorescent dye Hoechst 33342, often a characteristic property of less differentiated progenitor and STEM CELLS.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Static Electricity: The accumulation of an electric charge on a objectCattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Bacterial Proteins: Proteins found in any species of bacterium.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.Histidine: An essential amino acid that is required for the production of HISTAMINE.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Lysine: An essential amino acid. It is often added to animal feed.Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Facial Asymmetry: Congenital or acquired asymmetry of the face.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Hemiplegia: Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Oligopeptides: Peptides composed of between two and twelve amino acids.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.Rotation: Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Arginine: An essential amino acid that is physiologically active in the L-form.Peptoids: Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Cholesterol Side-Chain Cleavage Enzyme: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.Pain, Postoperative: Pain during the period after surgery.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Cadaver: A dead body, usually a human body.Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Posture: The position or attitude of the body.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Molecular Dynamics Simulation: A computer simulation developed to study the motion of molecules over a period of time.Dimerization: The process by which two molecules of the same chemical composition form a condensation product or polymer.Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Biophysics: The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Automobiles: A usually four-wheeled automotive vehicle designed for passenger transportation and commonly propelled by an internal-combustion engine using a volatile fuel. (Webster, 1973)Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Xenopus laevis: The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Protein Structure, Quaternary: The characteristic 3-dimensional shape and arrangement of multimeric proteins (aggregates of more than one polypeptide chain).Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Body Patterning: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Ion Channel Gating: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Behavior, Animal: The observable response an animal makes to any situation.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Cell Line, Tumor: A cell line derived from cultured tumor cells.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Biophysical Phenomena: The physical characteristics and processes of biological systems.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Models, Structural: A representation, generally small in scale, to show the structure, construction, or appearance of something. (From Random House Unabridged Dictionary, 2d ed)Mastication: The act and process of chewing and grinding food in the mouth.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Equipment Design: Methods of creating machines and devices.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Hypertrichosis: Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.Spectrophotometry: The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Paresis: A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). "General paresis" and "general paralysis" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Crystallography: The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Earnest Albert Craft, lives on the west side of Nashville in Bellevue. John Majors. "College Football". Tennessee Historical ... His first major coaching decision came on August 6, 2010, when he hired Herb Hand, former offensive co-coordinator at the Tulsa ... for its first major intersectional victory, "the crowning feat of the Southern Intercollegiate Athletic Association season." ... Decorated in orange and black, their automobile began the parade at Twelfth and Broadway, weaving through the side streets to a ...
It lies at the southern side of the entrance to Willapa Bay. Leadbetter Point is located at 46°39′0″N 124°3′40″W / 46.65000°N ... Majors, Harry M. (1975). Exploring Washington. Van Winkle Publishing Co. p. 115. ISBN 978-0-918664-00-6. Merriam-Webster's ...
Biosynthesis is the major source of CoQ10. Biosynthesis requires at least 12 genes, and mutations in many of them cause CoQ ... One possible side effect of statins is decreased production of CoQ10, which may be connected to the development of myopathy and ... There are two major factors that lead to deficiency of CoQ10 in humans: reduced biosynthesis, and increased use by the body. ... The most common side effects are gastrointestinal symptoms (nausea, vomiting, appetite suppression, and stomachaches), rashes, ...
Utterson, Major Moir, Major Vulliamy, Cpt. Anderson, Cpt. Creed, Cpt. Hyslop, Cpt. Stewart Savile Guides Infantry 51st Sikhs ... Artillery opened fire at noon, with sources disagreeing which side began the formal hostilities. As the British rushed to bring ... Acton, Major Graeme, Major Seppings, Cpt. Spragge, Cpt. Lloyd, Quartermaster Murray 6th Jat Light Infantry 45th Sikhs Other ... Major. H. B. Pearson led signallers to hold the Sarkai ridge and set up heliographs to communicate with the troops left in ...
Boat-tailed grackle, Quiscalus major (RI). Wood-warblers[edit]. Chestnut-sided warbler ...
Common side effects include nausea, diarrhea, and pain at the site of injection.[1] Other side effects may include Clostridium ... The most common side effects of imipenem are diarrhea, nausea, vomiting, skin rash, pruritus, and injection-site reactions. ... Major side effects requiring medical attention:[9] *Diarrhea. *Rash. *Fever. *Facial swelling ...
The major long-term complications relate to damage to blood vessels. Diabetes doubles the risk of cardiovascular disease[27] ... "GLUCAGON - INJECTION (Glucagon) side effects, medical uses, and drug interactions". MedicineNet. Retrieved 2018-02-05.. ... Major clinical trials. The Diabetes Control and Complications Trial (DCCT) was a clinical study conducted by the United States ... Inhalable insulin has been developed.[121] The original products were withdrawn due to side effects.[121] Afrezza, under ...
The MLS side, Tampa Bay Mutiny were the winners. In 2011 the stadium was repaired and improved to accommodate the new tenant ... Alan Gould (1936-02-11). "Majors' Spring Training Under Way Officially". The Meriden Daily Journal. p. 4. Retrieved 2011-03-06 ...
Majors, Harry M. (1975). Exploring Washington. Van Winkle Publishing Co. p. 115. ISBN 978-0-918664-00-6. History from Pacific ... Oysterville is located on the east side of the (north-south running) peninsula, on the shallow and sheltered Willapa Bay. ...
Major Interim Recommendations of Western GHats Task Force Western Ghats Task Force Dept. of Forest & Environment. Government of ... Rock engravings are found at Gavali, Udupi made during the megalithic period of a side view of a humped bull. Kasbekar, Durgesh ... Mhaskar, Major; Madhav, Vishweshwar; Dongre, Vrushal. Bhimgad a forest worth saving. Bhimgad site. Retrieved 2011-11-11. The ...
Towards the east side of the campus is the junior parking lot (tennis courts in the area were removed to expand the junior ... Scroggin, Joshua D. "Cal Poly's Haniger taken by Milwaukee in the Major League Baseball draft , Cal Poly". SanLuisObispo.com. ... The school is located near highway 280, and is bordered by Lawrence Expressway on one side and Queen of Apostles School on the ... Major League Baseball. Retrieved 9 January 2015. "Brandi Chastain - Awards And Accomplishments". Retrieved 9 January 2015. " ...
Major League Baseball paid the Orioles $75 million for a 10% stake in MASN, with the team maintaining a controlling interest of ... Robert J. Terry (July 25, 2005). "Judge sides with Orioles over Comcast in sports network feud". Baltimore Business Journal. " ... As with all Major League Baseball broadcasts, MASN-produced games are available for streaming out of the teams' respective ... Major League Baseball. August 4, 2006. "Not all getting O's new network". The Roanoke Times. November 10, 2008. Archived from ...
McCarthy, Kyle (4 June 2011). "Spain overpower experimental US side in 4-0 romp". Major League Soccer. Retrieved 28 May 2012. ... He made his first appearance for the B-side in Segunda División B as a second-half substitute, took part in the playoffs to ... On 4 June 2011 Valero made his debut for the full side, against the United States in Foxborough, Massachusetts. He replaced ...
"Sporting KC's Kamara loaned out to EPL side Norwich City". Major League Soccer. Retrieved 30 January 2013. "KAMARA GRANTED VISA ... Kei Kamara at Major League Soccer Kei Kamara Website Kei Kamara at National-Football-Teams.com Kei Kamara at Soccerbase. ... Seattle". Major League Soccer. Retrieved 6 May 2013. "Sporting KC loses Kei Kamara to Middlesbrough FC". kansascity.com. ... As part of the deal, Kamara's contract with Major League Soccer was extended. Norwich City announced on 5 February that Kamara ...
"Real Salt Lake officially unveil USL PRO side Real Monarchs SLC, in talks about possible NWSL team". www.mlssoccer.com. Major ... NASL side Indy Eleven, led by ex-Chicago-Red-Stars GM Peter Wilt, expressed interest in an NWSL side in 2015, contingent on ... FC Indiana is one of the strongest WPSL sides, and had competed in WPSL Elite along with eventual NWSL sides Boston, Chicago, ... USL side Sacramento Republic FC has also commented on Twitter several times in 2015 and 2016 that adding an NWSL side is part ...
Cubs , 08/03/16". Major League Baseball. Retrieved 2016-08-03. "Two homers, Kyle Hendricks lead Cubs to win". Major League ... Witz, Billy (2016-10-12). "Cubs Oust Giants to Reach N.L.C.S., for Once on Good Side of a Big Rally". The New York Times. ISSN ... Schwarber tore his ACL and LCL in his left knee on the play and was side-lined for the remainder of the regular season. April ... June 1 - Major League Baseball announced results of early All Star Game voting. The Cubs had five players in starting positions ...
In the American major leagues, Rule 1.10(a) states: The bat shall be a smooth, round stick not more than 2.61 inches in ... Manufacturers position each bat's label over the mechanically weaker side of the wood. To reduce chance of fracture, and maybe ... Since the bat regulations were set, there have not been many major design changes in the bats. Baseball bats are made of either ... According to Rule 1.10(c) of the Major League Baseball Rulebook, it is not allowed more than 18 inches up from the bottom ...
This command is not formally defined in an RFC, but is recognized by most major IRC daemons. Syntax: USER (RFC 1459) USER (RFC ... Adds or removes a user to a client's server-side friends list. More than one nickname may be specified in a space-separated ... This command is not formally defined in an RFC, but is used by most[which?] major IRC daemons. Syntax: SERVER The server ... This command is not formally defined in an RFC, but is in use by most major IRC daemons. Syntax: INFO [. ] Returns information ...
Lovell, Darrell (10 January 2013). "Dynamo confirm Hainault's exit to SPL side Ross County". mlssoccer.com. Major League Soccer ... "Defender leaves Staggies to join fellow SPL side". Inverness Courier. 25 May 2012. Retrieved 25 May 2012. "Bairns Confirm ...
Louis Browns in his first major league start (also not his first major league game). This game would prove to be one of only ... Toney retired the side in the bottom of the tenth and recorded a ten-inning no-hitter. This game was long considered a "double ... Three pitchers have thrown a no-hitter in their first major league starts; two others have done it in their second major league ... Ted Breitenstein pitched a no-hitter in his first Major League start on October 4, 1891, however, it was not his first Major ...
"Opinions vary over naming the growing Asian community on Houston's southwest side." (Archive). Alternate version without ... "Main Branch 6901 Corporate Drive Houston, Texas 77036." "Map Major Roads." Greater Sharpstown Management District. Retrieved on ... Opinions vary over naming the growing Asian community on Houston's southwest side." Houston Chronicle. Wednesday May 9, 2007. ...
... so Murphy was called up to the majors. In his first major league at bat, against three-time All-Star Roy Oswalt, Murphy hit a ... Murphy had a strained muscle on his right side during spring training. He returned to training on February 20, said he didn't ... Murphy was named to his first Major League Baseball All-Star Game in 2014 as the backup to starter Chase Utley. His roster ... In March 2015, Major League Ambassador for Inclusion Billy Bean visited the Mets spring training clubhouse. Murphy made ...
... loan him to Mexican side Zacatepec". Major League Soccer. "Canada selects 21 for the FIFA U-17 World Cup UAE 2013". October 3, ... He also played seven games for the Vancouver U-23 PDL side, scoring four goals. Bustos made his professional debut for ... Bustos made his debut for the senior side on October 13 as a substitute, replacing fellow debutante Charlie Trafford. Marco ... where he scored a goal for Canada against Russia's U-21 side. In January 2015 Bustos made the Canadian team for the 2015 ...
Finley signed with USL club Charlotte Independence on March 25, 2015.[dead link] Finley signed with Swedish side Ängelholms FF ... As of September 15, 2013 "Ryan Finley". Major League Soccer. Retrieved September 15, 2013. "Ryan Finley". Notre Dame. Retrieved ... "Columbus Crew 2, Houston Dynamo 0 , MLS Match Recap". Major League Soccer. Retrieved September 15, 2013. "Crew acquires ...
Major, J Kenneth (1977). The Windmills of John Wallis Titt. The International Molinological Society. pp. 8, 30. "THE HUNDRED OF ... "WINDMILL, MOOR LANE (north side), CROSBY, SEFTON, MERSEYSIDE". English Heritage. Retrieved 19 November 2008. de Little, Rodney ... Major, J Kenneth; Watts, Martin (1977). Victorian and Edwardian Windmills and Watermills from old photographs. London: Batsford ... Postcard published by Knowsley Library Service "WINDMILL, CRAGGS ROW (east side), PRESTON, PRESTON, LANCASHIRE". English ...
Major topics[edit]. Research in computational neuroscience can be roughly categorized into several lines of inquiry. Most ... Chklovskii DB (2004). "Synaptic connectivity and neuronal morphology: two sides of the same coin". Neuron. 43 (5): 609-17. doi: ... One of the major problems in neurophysiological memory is how it is maintained and changed through multiple time scales. ...
"The Other Side" is a single by Canadian country music artist Charlie Major. Released in 1994, it was the fourth single from ... Majors debut album The Other Side. The song reached #1 on the RPM Country Tracks chart in August 1994. RPM Country Tracks "Top ...
Major) - 3:24 "Walk Away" (Major) - 4:20 "The Other Side" (Major) - 3:07 "Ill See You in My Dreams" (Major) - 3:23 allmusic. ... Major, Brown) - 3:34 "It Cant Happen to Me" (Major) - 3:58 "Im Here" (Major, Brown) - 3:32 "Running in the Red" (Major, ... The Other Side is the debut album of Canadian country music artist Charlie Major. All six singles released from the album went ... "Im Gonna Drive You Out of My Mind" (Charlie Major, Barry Brown) - 4:07 "Im Somebody" ( ...
Is it side effects of coming of the drug or is it depression? I really dont know. I dont want to be dependent on drugs, but, ... SSRIs do have major dependancy issues. I know because I went off Cipramil cold turkey under the instruction of a doctor (who ... He has read up on prozac and it seems like it is technically the safest but nobody knows what the long term side effects are ... I was on and off Prozac for more than 10 years and my only apparent side effect was sexual dysfunction. Not a small thing, but ...
Wesley Reisz talks to Charity Majors, cofounder and CEO of honeycomb.io. They discuss the social side of debugging and her ... InfoQ Homepage Podcasts Charity Majors on Honeycomb.io, the Social Side of Debugging and Testing in Production ... Charity Majors on Honeycomb.io, the Social Side of Debugging and Testing in Production ... They discuss the social side of debugging and her Strange Loop talk "Observability for Emerging Infra: What got you Here Wont ...
Side effects of vitamin D-3 may include fatigue, hives or itching, cough, difficulty swallowing, fast heartbeat, skin rash, ... Are there any side effects to bathing with Epsom salts?. A: The side effects of soaking in Epsom salts (magnesium sulfate) ... What are the side effects of Omega 3 fatty acid supplements?. A: Side effects of omega-3 fatty acid fish oil supplements ... What are side effects of taking cholecalciferol?. A: Possible side effects of taking cholecalciferol include skin rash, ...
... display-buffer-in-major-side-window was renamed without an alias., Phil Sainty ,= *bug#31194: 26.1; `display-buffer-in-major- ... bug#31194: 26.1; `display-buffer-in-major-side-window was renamed without an alias., Phil Sainty, 2018/04/17. *bug#31194: 26.1 ... bug#31194: 26.1; `display-buffer-in-major-side-window was renamed without an alias., Phil Sainty, 2018/04/17. *bug#31194: 26.1 ... bug#31194: 26.1; `display-buffer-in-major-side-window was renamed without an alias., Phil Sainty, 2018/04/18. *bug#31194: 26.1 ...
Home Life and Science Health and Education Medical Professionals File Major Federal Health Care Lawsuit Against Virginia ... Right Side News stands out among news sites, offering the right news from sources you can trust. Find out what the real news is ... Right Side News is your online newspaper, publishing accurate information about threats against Western civilization. ... question posed by a coalition of medical professionals who today joined forces with the Institute for Justice to file a major ...
But they must read side effects associated with testosterone boosters. ... What are the Major Side Effects of Testosterone Boosters?. Many potential side effects result from taking testosterone boosters ... Know Here the Major Side Effects of Using Testosterone Boosters. Reprinting this article:. Non-commercial use OK, cite ... One of the major potential side effects that are associated with testosterone boosters is kidney failure. Several studies have ...
No major side-effects of HCQ, should be continued as preventive treatment for COVID-19: ICMR PTI New Delhi, May 26, 2020 18:34 ... No major side-effects of hydroxychloriquine have been found in studies in India and its use should be continued in preventive ... No major side-effects of HCQ, should be continued as preventive treatment for COVID-19: ICMR ... "We found there were no major side affects except for nausea, vomiting, palpitation occasionally. Hence in our advisory we have ...
... Member Center ... SPECIAL REPORT: Dangerous bacterial disease causes major concern with pet owners. 2017-04-28T15:28:28Z. 2017-05-02T20:22:18Z. ...
... but the treatment can result to some risk and side effects.Know how it can cause hearing loss. ... One of the major botox injection side effects is hearing loss. As it is essential in offering essential treatment options, it ... In addition, we have to know how it is administered, how it works and the possible botox side effects that come as a result of ... You will find that one of the botox side effects is that it can cause hearing impairment, tinnitus or complete hearing loss. ...
GEOMAR researchers show limitations and side effects of large-scale climate intervention With global greenhouse gas emissions ... 84 thoughts on "Study: Climate Engineering: minor potential to reduce warming, major side effects" * SteveB. says: ... The major side effects to climate engerneering is weather modification = climate change. Temperature = electric potential at ... "Study: Climate Engineering: minor potential to reduce warming, major side effects". File this under Dispatches from the desk ...
Research to reduce side effects of treatments for major diseases receives £300,000 prize from IET. ... She was chosen due to her outstanding contributions to biomedical engineering and her research into the treatment of major ... Professor Strides targeted drug delivery research concerns the treatment of major diseases such as cancer and stroke, where ... The key motivation is to reduce serious side effects and increase the number of patients eligible for treatment. ...
Inc side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Major Pharmaceuticals, Inc ... Get up-to-date information on Major Pharmaceuticals, ... Major Pharmaceuticals, Inc manufacturers the following brands: ...
A major asthma drugmaker has been quietly investing in coal on the side. The pharmaceutical company that just months ago was ... On Thursday morning, the Supreme Court handed down two major rulings on gerrymandering and the census, and yet, only a few ... The comments represented the first time Democratic candidates spoke about issues facing the trans community on a major debate ...
... are there any major organs on the left side of your body, major organs on the left side of the body, major organs on the left ... side of your body, what major organs are located on the left side of your body ... See more about Major Organs On The Left Side Of Your Body, ... Major Organs On The Left Side Of Your Body - ... "Major Organs On The Left Side Of Your Body". Major Organs On The Left Side Of Your Body Major Organs On The Left Side Of Your ...
The first of a two-part series that talks about the side effects of chemotherapy, and what measures doctors take to help ... The 9 Major Side Effects of Chemotherapy -Part I. This is the first of a two-part series that talks about the side effects of ... Neutropenia is the lowering of your white blood cell count, which is a major side effect of chemo drugs. White blood cells play ... The 9 Major Side Effects of Chemotherapy - Part II. How to Cope. ... But that is only one of the possible side effects.. Effects in ...
Side Hero Ad. #php_widget-131, #php_widget-140 { padding: 0px; margin: 0px; } #php_widget-104, .today-on-the-show-content { ... Just a few days ago, I explained that the IMF, the UN, the BIS And Citibank were all warning that a major economic crisis could ... As you will see below, money is fleeing emerging markets at a blistering pace, major global banks are stuck with huge loans ... The following is an excerpt from an article that was just published in a major British news source entitled "The world economic ...
Side Hero Ad. #php_widget-131, #php_widget-140 { padding: 0px; margin: 0px; } #php_widget-104, .today-on-the-show-content { ... Alex Jones: ANTIFA Uprising A Major FAIL For Soros. Protests attended by snowflakes and unicorns. The Alex Jones Show - ... Alex Jones joins the Nov 4th broadcast to watch in real time as ANTIFA and Soros suffer a major FAIL. ...
The Forest Side restaurant, Grasmere - review Riding Napas Silverado Trail: 10 wineries to visit ...
It is likely that current dental services are coping better to prevent tooth loss than in the past but major efforts are needed ... Untreated tooth decay or cavities in permanent teeth - also known as dental caries - was the most common of all 291 major ... The Global Burden of Diseases, Injuries, and Risk Factors Study commenced in the spring of 2007 and was a major effort ... Drugs - Side Effects. *How to Take Drugs. * *Drugs by Specialty. *Health Conditions Due to Drugs ...
The month of May saw major announcements in breakthrough therapies by companies working on the Beta-Thalassemia curatives - ... The month of May saw major announcements in breakthrough therapies by companies working on the Beta-Thalassemia curatives - ... the standard protocol for treatment of Beta-Thalassemia major is lifelong blood transfusions along with regular iron chelation ... Drugs - Side Effects. *How to Take Drugs. * *Drugs by Specialty. *Health Conditions Due to Drugs ...
5 yr old Calico male cat has major swelling in his abdomen on the sides and the bottom.. All questions. Answered questions. ...
A major review, led by BHF Professor Sir Rory Collins, suggests the benefits of statins have been underestimated and their ... When is a side effect not a side effect? Read our Medical Directors blog on the new review. ... Major review of statins evidence by BHF Professor shows benefits of drug 8 September 2016 BHF Press Office Category: Research ... Exaggerated side effects. Professor Collins and his colleagues felt the potential harms of statins had been exaggerated after ...
The Illinois House today approved a major change in the state pension system that could save an estimated $100 billion by ... Illinois House approves major pension reform bill News Posted: Mar 21, 2013 / 02:35 PM CDT. / Updated: Mar 21, 2013 / 04:56 PM ... The Illinois House today approved a major change in the state pension system that could save an estimated $100 billion by ... have for years debated how to deal with the nations most underfunded public employee pension system without taking major ...
  • The key motivation is to reduce serious side effects and increase the number of patients eligible for treatment. (theiet.org)
  • This is the first of a two-part series that talks about the side effects of chemotherapy, and what measures doctors take to help patients cope with them. (hope4cancer.com)
  • The review concluded that lowering cholesterol by 2 mmol/L with an effective low-cost statin therapy for five years in 10,000 patients would prevent major cardiovascular events, such as heart attacks or strokes, in 1000 people with pre-existing cardiovascular disease. (bhf.org.uk)
  • For primary prevention, where people are at increased risk because they have cardiovascular disease risk factors, such as diabetes or high blood pressure , the researchers found that lowering cholesterol by 2mmol/L for five years in 10,000 patients would prevent major events in 500 people. (bhf.org.uk)
  • Exclusive GPs face a major upheaval to the way they assess patients for statin treatment, after the Joint British Societies decided to ditch 10-year risk prediction in favour of the QRisk Lifetime Score. (pulsetoday.co.uk)
  • Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4 [see CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • Colon cancer arising on the left side versus the right side of the colon portrays different outcomes, emerging PTL as an important characteristic in understanding the outcomes for patients with colorectal cancer. (springer.com)
  • Patients with right-sided tumors have a worse prognosis than those with left-sided tumors. (springer.com)
  • Overall, for patients who can be treated with docetaxel and similar drugs the data provide an indication of a major added benefit of nivolumab over the appropriate comparator therapy. (eurekalert.org)
  • Update: an an interesting side issue is that it appears that nearly 10% of the patients in the trial appear not to have been actually complying with the drug dosing, according to the blood work. (sciencemag.org)
  • Researchers from the University of Illinois at Chicago looked at how many prescriptions are being issued to this age group, how many medications they were taking at one time, as well as major drug interactions. (go.com)
  • Among those using multiple medications, one in 12 was at risk for a major drug interaction, and the vast majority of these potential interactions involved antidepressants. (go.com)
  • According to the findings, there is an indication of major added benefit of nivolumab over the appropriate comparator therapy docetaxel for under-75-year-olds in relatively good general condition, and a hint of a non-quantifiable added benefit for over-75-year-olds in relatively good general condition. (iqwig.de)
  • Their median survival time was 9.5 months, which is 3.5 months longer than in the docetaxel arm of the study (6 months): an indication of major added benefit. (iqwig.de)
  • Although no benefit in overall survival (OS) has been demonstrated, available data up to now can endorse the use of an anti-EGFR in right-sided RAS wild-type advanced colorectal cancer if the therapy goal is tumor shrinkage (given the higher objective response rate). (springer.com)
  • Location of colon cancer (right-sided versus left-sided) as a prognostic factor and predictor of benefit from cetuximab in NCIC CO.17. (springer.com)
  • According to the findings, there is an indication of a major added benefit of nivolumab over docetaxel. (eurekalert.org)
  • In the outcome category "side effects", there was a hint of lesser harm from nivolumab in each case for treatment discontinuations due to adverse events and for severe adverse events. (iqwig.de)
  • Only qualitative interpretation was possible of the data on specific side effects because of the different observation durations in the study arms: There was a hint of lesser harm from nivolumab in each of the non-severe specific adverse events "myalgia", "peripheral neuropathy" and "alopecia", and an indication of lesser harm in blood and lymphatic system disorders. (iqwig.de)
  • Nivolumab also has advantages over docetaxel with regard to several outcomes from the category "side effects" (severe and serious adverse events, discontinuation due to adverse events, alopecia, and blood and lymphatic system disorders). (eurekalert.org)
  • Not every known side effect, adverse effect, or drug interaction is in this database. (psychcentral.com)
  • I've found this slideshow on another site that claims to have 10 streches to cover all your major muscle groups. (exrx.net)
  • The month of May saw major announcements in breakthrough therapies by companies working on the Beta-Thalassemia curatives - LentiGlobin BB305 and Luspatercept. (medindia.net)
  • The major breakthrough as far as philosophy and the ancient sciences are concerned occurred from the mid-eighth to the first third of the ninth centuries under the Abbasid dynasty (750 - 1258). (encyclopedia.com)
  • There is a great necessity to improve our understanding of the molecular and histological variability in left versus right-sided colon cancer and its impact on future targeted therapy. (springer.com)
  • 5 yr old Calico male cat has major swelling in his abdomen on the sides and the bottom. (deltarescue.org)
  • The abdomen is made up of four major muscle groups: rectus abdominis, internal and external obliques, and the transverse abdominis, which is the deepest abdominal layer of muscle. (livestrong.com)
  • Untreated tooth decay or cavities in permanent teeth - also known as dental caries - was the most common of all 291 major diseases and injuries assessed by the GBD 2010 study, affecting 35 per cent of the world population. (medindia.net)
  • The Global Burden of Diseases, Injuries, and Risk Factors Study commenced in the spring of 2007 and was a major effort involving nearly 500 scientists carrying out a complete systematic assessment of global data on all diseases and injuries. (medindia.net)
  • The tasks of the Chang'e-4 include astronomical observation, surveying the moon's terrain, landform and mineral makeup, and measuring the neutron radiation and neutral atoms to study the environment of its far side. (reuters.com)
  • Axia3 ( http://www.Axia3.com ), the fast acting, all natural treatment for heartburn, proudly announces its selection as the preferred antacid among a majority of participants in a major, independent blind study concerning various prescription and over-the-counter remedies for this chronic ailment. (prweb.com)
  • The major course work provides an overview of the entire field of astronomy, more detailed work in specific areas of astronomical importance, and the solid background in physics and mathematics that is needed to pursue graduate study. (benedictine.edu)
  • Two leading South African HIV experts reflect on the future of new ARVs dolutegravir and TAF, following the publication of findings from a major new trial conducted in Johannesburg. (aidsmap.com)
  • As you will see below, money is fleeing emerging markets at a blistering pace, major global banks are stuck with huge loans that will never be repaid, and it looks like a very significant worldwide credit crunch has begun. (infowars.com)
  • One of the most common side effects of constipation, high toxicity in the blood, or poor dietary habits is skin inflammation, manifesting as spots, pimples, acne, rashes or discoloration. (educared.net)
  • The major muscle groups in the upper body are the deltoid muscles in the shoulders, the biceps and triceps in the arms, the pectoral muscles in the chest, and the back muscles. (livestrong.com)
  • The shoulder stretch (8) appears to be a cross of the side deltoid and the rear deltoid stretch. (exrx.net)
  • BEIJING (Reuters) - A Chinese space probe successfully touched down on the far side of the moon on Thursday, China's space agency said, hailing the event as a historic first and a major achievement for the country's space program. (reuters.com)
  • At least five people were killed on Sunday when Taliban suicide attackers targeted a major US base in Jalalabad, Afghanistan, highlighting the country's security challenges ahead of the 2014 NATO troop pullout. (france24.com)
  • Suicide attackers detonated bombs and fired rockets outside a major U.S. base in Afghanistan on Sunday, killing five people in a brazen operation that highlighted the country's security challenges ahead of the 2014 NATO combat troop pullout. (france24.com)
  • However, it is important to be aware of these minor side effects to decide whether you are willing to experience them in order to get the expected results. (consumerhealthdigest.com)
  • And, discover the importance of different types of college classes including those from the core curriculum, electives, and major/minor ones. (collegesurfing.com)
  • however, there were still major differences between 2 years and adults whom exhibited the lowest interindividual diversity. (wiley.com)
  • Most testosterone supplements really work, but that every testosterone booster has some side effects, including even the finest products in the market. (consumerhealthdigest.com)
  • Therefore, the most important thing is to consults your doctor to enable you get effective testosterone boosters with less testosterone booster side effects. (consumerhealthdigest.com)
  • It has significant levels of vitamin C and vitamin E, both of which act as antioxidants in the body to eliminate free radicals, which means that burdock is a major booster of our immune system. (educared.net)
  • She was chosen due to her outstanding contributions to biomedical engineering and her research into the treatment of major diseases. (theiet.org)
  • It is likely that current dental services are coping better to prevent tooth loss than in the past but major efforts are needed to prevent the occurrence and development of gum diseases and tooth decay. (medindia.net)
  • A major review suggests the benefits of statins have been underestimated and their potential harms exaggerated, due to failings in acknowledging the evidence from randomised trials and the limitations of other types of studies. (bhf.org.uk)
  • However, like all drugs, they can have side effects, and this class of medication does pose a risk of addiction for some. (everydayhealth.com)
  • Despite the implementation of national programs focusing on medication safety, side effects related to medications remain a leading cause of injuries and death among children and adolescents in the United States. (go.com)
  • Maintenance of petroleum process plant systems as a source of major accidents? (bibsys.no)
  • The prevention of hydrocarbon leaks is of great importance as they are the most critical precursor events that may lead to major accidents on petroleum facilities. (bibsys.no)
  • Maintenance of process components on offshore and onshore petroleum facilities is therefore crucial in order to avoid major accidents, such as Piper Alpha and Texas City. (bibsys.no)
  • This comprehensive review reiterates the life saving benefits of statins, which vastly outweigh the rare side effects associated with the medicine. (bhf.org.uk)
  • Major Organs On The Left Side Of Your Body - May 25, 2018 by Catrina. (corpbancacentrocultural.com)
  • WASHINGTON, D.C. - Food waste, digital and online innovations, and consumer values are expected to drive some of the major food and nutrition trends in 2018, according to the International Food Information Council (IFIC) Foundation. (foodinsight.org)
  • No major side-effects of hydroxychloriquine have been found in studies in India and its use should be continued in preventive treatment for COVID-19 , the Indian Council of Medical Research (ICMR) said on Tuesday. (thehindu.com)
  • Nadolol has low lipophilicity as determined by octanol/ water partition coefficient, a characteristic of certain beta-blocking agents that has been correlated with the limited extent to which these agents cross the blood-brain barrier, their low concentration in the brain, and low incidence of CNS-related side effects. (drugs.com)
  • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. (springer.com)
  • Even though it can be quite poisonous in nature, it has been proven that usage in small and regulated quantities can result in major health improvements. (consumerhealthdigest.com)
  • Eating too many jujube fruits is bad for our health, and in this article, we will know about the major side effects of consuming too many jujubes , but first, let's take a look at the below-mentioned nutrition chart of jujube. (goodhealthall.com)
  • Although dietary fibers are good for our digestive health, it is recommended to be on the safe side and enjoy the fruit in moderation. (goodhealthall.com)
  • The Better Sleep Pillow is created with a center & side recess, which easily accommodates stomach, side and back sleepers, perfectly contouring the upper body while in any sleeping position. (allegromedical.com)
  • Great Northern Highway is the major road connection through the region, with sealed roads spurring off it to connect to population centres, and unsealed roads offering an alternative route between Derby and Wyndham. (wikipedia.org)
  • Taken together, the major age-affiliated population shift within gut microbiota suggests that there are important mechanisms for transmission and persistence of gut bacteria that remain unknown. (wiley.com)
  • Just a few days ago, I explained that the IMF, the UN, the BIS And Citibank were all warning that a major economic crisis could be imminent . (infowars.com)