Disorders of the blood and blood forming tissues.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
The condition of being heterozygous for hemoglobin S.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Surgical procedure involving either partial or entire removal of the spleen.
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.
Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.
An island in the Greater Antilles in the West Indies. Its capital is Kingston. It was discovered in 1494 by Columbus and was a Spanish colony 1509-1655 until captured by the English. Its flourishing slave trade was abolished in the 19th century. It was a British colony 1655-1958 and a territory of the West Indies Federation 1958-62. It achieved full independence in 1962. The name is from the Arawak Xaymaca, rich in springs or land of springs. (From Webster's New Geographical Dictionary, 1988, p564 & Room, Brewer's Dictionary of Names, 1992, p267)
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Infections with fungi of the genus ASPERGILLUS.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
An individual in which both alleles at a given locus are identical.
Members of the beta-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 11. They include epsilon-globin, gamma-globin, delta-globin and beta-globin. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult HEMOGLOBIN is comprised of two ALPHA-GLOBIN chains and two beta-globin chains.
A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.
The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Members of the beta-globin family. In humans, two non-allelic types of gamma-globin - A gamma and G gamma are encoded in the beta-globin gene cluster on CHROMOSOME 11. Two gamma-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Portland. Fetal HEMOGLOBIN F is formed from two gamma-globin chains combined with two ALPHA-GLOBIN chains.
A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.
The PROTEIN SUBUNITS that comprise multimeric HEMOGLOBINS.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.
Medical tests taken by couples planning to be married in order to determine presence of genetic and contagious diseases.
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
A member of the beta-globin family. In humans, delta-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two delta-globin chains along with two alpha-globin chains form HEMOGLOBIN A2 which makes up about 3% of the HEMOGLOBIN in adults.
A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
Pathologic inclusions occurring in erythrocytes.
A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Pathological processes involving any part of the LUNG.
An independent state, an archipelago in the western Persian Gulf, northwest of Qatar. It comprises low-lying islands of Bahrain (the largest), Muharraq, Sitra, and several islets. It has extensive oil fields. The name comes from the Arabic al-bahrayn, "the two seas", with reference to its lying in the middle of a bay with its "two seas" east and west of it. (From Webster's New Geographical Dictionary, 1988, p107 & Room, Brewer's Dictionary of Names, 1992, p45)
Pressure, burning, or numbness in the chest.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.
Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).
Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Disease having a short and relatively severe course.
Techniques or methods of patient care used by nurses as primary careproviders.
Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Enlargement of the spleen.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Individuals whose ancestral origins are in the continent of Africa.
Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
A 1:1 molar complex of heme or hematin and albumin formed after the dissociation of methemoglobin into heme or hematin and globin in plasma. This complex, which imparts a coffee-brown color to plasma, occurs in hemolytic and hemorrhagic disorders. Its presence in plasma is used as a test to differentiate between hemorrhagic and edematous pancreatitis.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An infant during the first month after birth.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Persons living in the United States having origins in any of the black groups of Africa.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Surgical removal of the GALLBLADDER.
The series of cells in the red blood cell lineage at various stages of differentiation.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Tests used in the analysis of the hemic system.
Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.
Child hospitalized for short term care.
Adherence of cells to surfaces or to other cells.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Hereditary elliptocytosis Sickle-cell disease List of hematologic conditions Wrong, O; Bruce, LJ; Unwin, RJ; Toye, AM; Tanner, ... Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 34: 153-159. doi:10.1016/j.meegid.2015.06. ... Rather, the defect lies in a protein known as the band 3 protein, which lies in the cell membrane itself. The band 3 protein ... The band 3 proteins aggregate on the cell membrane at the site of entry, forming a circular orifice that the parasite squeezes ...
... including sickle cell disease) Systemic diseases: sarcoidosis, pulmonary Langerhans cell histiocytosis: ... Pulmonary hypertension with unclear or multifactorial mechanisms Hematologic diseases: chronic hemolytic anemia ( ... sickle cell disease, cocaine use, chronic obstructive pulmonary disease, sleep apnea, living at high altitudes, and problems ... However, in systemic lupus erythematosus it is 4 to 14%, and in sickle cell disease, it ranges from 20 to 40%. Up to 4% of ...
Hematologic diseases Hemoglobinopathies Sickle cell disease β thalassemia major (Cooley's anemia) Anemias Aplastic anemia ... Solid tumor cancers Neuroblastoma Desmoplastic small round cell tumor Ewing's sarcoma Choriocarcinoma Hematologic disease ... I-cell disease) Fucosidosis Aspartylglucosaminuria Alpha-mannosidosis Other Wolman disease (acid lipase deficiency) ... amyloidosis Environmentally-induced diseases Radiation poisoning Viral diseases HTLV HIV Autoimmune diseases Multiple sclerosis ...
Myeloproliferative disease Leukaemia Lymphoma Pernicious anaemia Sickle cell anaemia Hereditary Spherocytosis Thalassaemia ... Fasciolosis Typhoid fever Schistosomiasis or filariasis importants Septicemic plague Histoplasmosis Hematologic diseases: ... Niemann-Pick disease Gaucher's disease[citation needed] Hurler's syndrome[citation needed] Chronic liver disease and portal ... and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous ...
... multiple myeloma and sickle cell anaemia. Infectious, such as Lyme disease and osteomyelitis. Neurological, such as spinal cord ... inflammatory bowel disease (including Crohn's disease and ulcerative colitis). Hematologic, such as Cushing's syndrome, ... However, in certain diseases the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, ... Bone tumors are composed of a conglomeration of cell types including cancer and immune system cells. Often tumor cells secrete ...
Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease & complications from chemotherapy or ... Sickle cell disease Thalassemia Methemoglobinemia Anemias (lack of red blood cells or hemoglobin) Iron-deficiency anemia ... Rh disease (Rh D) ABO hemolytic disease of the newborn Anti-Kell hemolytic disease of the newborn Rhesus c hemolytic disease of ... T-cell prolymphocytic leukemia (T-PLL) B-cell prolymphocytic leukemia (B-PLL) Chronic neutrophilic leukemia (CNL) Hairy cell ...
... sickle-cell disease and thalassemia. Several inherited disorders have been linked to osteoporosis. These include osteogenesis ... Chronic kidney disease can lead to renal osteodystrophy.[citation needed] Hematologic disorders linked to osteoporosis are ... "What People With Celiac Disease Need To Know About Osteoporosis , NIH Osteoporosis and Related Bone Diseases National Resource ... It is also more frequent in people with Parkinson's disease and chronic obstructive pulmonary disease.[citation needed] People ...
Hematologic conditions associated with sluggish blood flow can increase risk for thrombosis. For example, sickle-cell disease ( ... Nephrotic syndrome, in which protein from the bloodstream is released into the urine due to kidney diseases, can predispose to ... Inflammatory bowel disease (ulcerative colitis and Crohn's disease) predispose to thrombosis, particularly when the disease is ... the arterial disease that underlies myocardial infarction and other forms of cardiovascular disease. Tests for thrombophilia ...
... sickle cell disease; diabetes mellitus; postsplenectomy; the newborn; and the administration of cytotoxic agents or ... 946-956); In Principles and Practice of Pediatric Infectious Diseases, Eds. Long, S.S., Pickering, L.K., and Prober, C.G. ... The main factors which predispose to anaerobic bacteremia are: hematologic disorders; organ transplant; recent gastrointestinal ... Reviews of Infectious Disease. 13: 819-822; 1991. Finegold SM. Anaerobic bacteria in human disease. Orlando: Academic Press Inc ...
Beginning in 1920, doctors at Johns Hopkins Hospital conducted research on sickle cell anemia, or sickle cell disease. Although ... While there, he studied blood-related diseases, such as blood coagulation and sickle cell anemia, and invented machinery to ... Hematologic studies were prominent at Johns Hopkins Hospital prior to the discovery of the hemoglobin Hopkins-2 variant. After ... There is a lack of phenotypic expression of Ho-2 in terms of sickle cell, so a person with sickle cell and hemoglobin Hopkins-2 ...
It can be a serious disease if not treated early. Sometimes it can be cured by chemotherapy or stem cell treatment. It can ... "Anemia in Kidney Disease and Dialysis". The National Kidney and Urologic Diseases Information Clearinghouse. National Institute ... "Sickle Cell Trait and Other Hemoglobinopathies and Diabetes: Important Information for Physicians". National Diabetes ... "Hematologic (Blood) Cancers". Centers for Disease Control and Prevention. Retrieved 25 January 2011. McPhee, Stephen; Ganong, ...
... and her landmark research established one of the earliest links between genetic factors and sickle cell disease. On her demise ... Curious about blood diseases and disorders, he chose to focus on the field during his fellowship between 1982 and 1986 at the ... of new knowledge and a passion to translate that new knowledge into the tools to help patients with hematologic disease. During ... Pioneer in Sickle Cell Research, Dies at 89". The New York Times. Retrieved 14 August 2012. CS1 maint: discouraged parameter ( ...
... or a disease such as sickle cell anaemia. Hyposplenia refers to a partially functioning spleen. These conditions may cause a ... In the early 18th century, the physician Richard Blackmore considered it to be one of the two most prevalent diseases in ... After birth, erythropoietic functions cease, except in some hematologic disorders. As a major lymphoid organ and a central ... Gaucher's disease, leishmaniasis, Hodgkin's disease, Banti's disease, hereditary spherocytosis, cysts, glandular fever ( ...
Hematologic, such as Cushing's syndrome, histiocytosis, multiple myeloma and sickle cell anaemia.[7] ... inflammatory bowel disease (including Crohn's disease and ulcerative colitis).[7][8][9] ... Viral diseases, including the measles, influenza, mononucleosis, chickenpox, and mumps.[citation needed] ... Bone tumors are composed of a conglomeration of cell types including cancer and immune system cells. Often tumor cells secrete ...
... and red blood cells containing abnormal hemoglobins (such as Hemoglobin S in sickle cell disease) as white blood cells, leading ... In leukemias and other hematologic malignancies, the lineage and genetic characteristics of white blood cells have important ... such as blood disorders and inflammatory diseases. Five types of white blood cells are normally found in blood: neutrophils, ... Blast cell Blast cells are very immature cells that are normally found in the bone marrow, where they develop into mature cells ...
... such as sickle cell anemia and thalassemia, as well as conditions of red cell structural and enzymatic abnormalities such as ... Hemolytic anemia, aplastic anemia and anemia due to hematologic or non-hematologic (ie, colonic adenocarcinoma) malignancy may ... Transfusion transmissible diseases include, but are not limited to the following: human immunodeficiency virus (HIV), hepatitis ... Treatment should target the underlying disease or condition affecting the patient. The majority of obstetric anemia cases can ...
Allergy and autoimmune diseases such as Parkinson's and Alzehimers disease. Genetic factors: Such as Down's syndrome and sickle ... Hyperactive apoptosis can lead to neurodegenerative diseases, hematologic diseases, and tissue damage. When a cell is damaged ... Stromal cells are the cells that support the parenchymal cells in any organ. Fibroblasts, immune cells, pericytes, and ... Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as ...
J Clin Invest 40: 1856-1871, 1961 Beutler E. The effect of carbon monoxide on red cell life span in sickle cell disease. Blood ... He made important discoveries about the causes of a number of diseases, including anemias, Gaucher disease, disorders of iron ... an improvement that preceded any major hematologic change, and showed that numerous enzymes were sensitive to iron deficiency. ... J Lab Clin Med 68: 137-141, 1966 Beutler E. The effect of methemoglobin formation in sickle cell disease. ...
A study aimed at detecting the genes that could give rise to offspring with sickle cell disease. Patients diagnosed with beta ... Beta thalassemia is a hereditary disease affecting hemoglobin. As with about half of all hereditary diseases, an inherited ... those who inherit a beta thalassemic mutation but have no hematologic abnormalities nor symptoms. Some people with thalassemia ... "Gene Therapy Shows Promise for Treating Beta-Thalassemia and Sickle Cell Disease". 2012-03-28. Retrieved 2015-10-15. Uranüs, ...
... the presence of sickle cells is indicative of sickle cell disease, and a high number of fragmented red blood cells ( ... It can also be caused by diseases that involve abnormal production of blood cells, such as myeloproliferative and ... such as blast cells or lymphocytes with neoplastic features, is suggestive of a hematologic malignancy. Platelets play an ... sickle cell disease and hemoglobin C disease. An elevated MCHC can also be a false result from conditions like red blood cell ...
Diagnosis is made by first ruling out other causes of hemolytic anemia, such as G6PD, thalassemia, sickle-cell disease, etc. ... Secondary causes of autoimmune hemolytic anemia include: Autoimmune diseases, such as lupus Chronic lymphocytic leukemia Non- ... Hematology Hemolytic anemia List of circulatory system conditions List of hematologic conditions Splenomegaly Shoenfield, Y; et ... Cold agglutinin disease is treated with avoidance of cold exposure. Patients with more severe disease (symptomatic anemia, ...
Due to underlying diseases that destroy the spleen (autosplenectomy), e.g. sickle-cell disease. Celiac disease: unknown ... Halfdanarson, T. R.; Litzow, M. R.; Murray, J. A. (15 January 2007). "Hematologic manifestations of celiac disease". Blood. 109 ... Functional asplenia occurs when splenic tissue is present but does not work well (e.g. sickle-cell disease, polysplenia) -such ... Furthermore there is a deficiency of other splenic cells e.g. splenic macrophages. This combined with the lack of B cells can ...
Hematologic disease: Monocyte and granulocyte disease (CFU-GM/CFU-Baso/CFU-Eos), including immunodeficiency (D70-D71, 288) ... Sickle-cell anemia. *Polysaccharide encapsulated bacteria,[6] particularly: *Streptococcus pneumoniae[6]. *Haemophilus ... Many specific diseases directly or indirectly cause immunosuppression. This includes many types of cancer, particularly those ... Wegner's disease) and NK/T cell lymphomas. Wiskott-Aldrich syndrome (WAS) patients also present with eczema, autoimmune ...
Sickle-cell disease/trait. *Hereditary persistence of fetal hemoglobin. *membrane: Hereditary spherocytosis *Minkowski- ... "Gaisböck's syndrome: its hematologic, biochemical and hormonal parameters". Angiology. 29 (7): 520-533. doi:10.1177/ ... Diseases of red blood cells (D50-69,74, 280-287). ↑. Polycythemia. *Polycythemia vera ... Neoplasms - Renal cell carcinoma or liver tumors, von Hippel-Lindau disease, and endocrine abnormalities including ...
Sickle-cell disease/trait. *HPFH. *membrane: Hereditary spherocytosis *Minkowski-Chauffard syndrome. *Hereditary elliptocytosis ... List of hematologic conditions. References[edit]. *^ "Megaloblastic Anemia: Overview - eMedicine Hematology". Retrieved 2009-02 ... Diseases of red blood cells (D50-69,74, 280-287). ↑. Polycythemia. *Polycythemia vera ... Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body ...
"Cell Death & Disease. 10 (10): 782. doi:10.1038/s41419-019-2015-1. PMC 6791888. PMID 31611560.. ... 4: Infectious Diseases". In McPhee SJ, et al. (eds.). Pathophysiology of Disease (6th ed.). New York: McGraw-Hill. ISBN ... Hematologic dysfunction *platelet count , 80,000/mm3 or 50% drop from maximum in chronically thrombocytopenic, or ... Neutrophils, monocytes, macrophages, dendritic cells, CD4+ T cells, and B cells all undergo apoptosis, whereas regulatory T ...
sickle cell disease. *Alpha-thalassemia, e.g. HbH disease. Extrinsic causes of hemolysis[edit]. *Systemic conditions *Sepsis ... and other pediatric liver diseases should be considered. The evaluation for these will include blood work and a variety of ... hematologic disease. *Vitamin K deficiency *Haemorrhagic disease of the newborn. *HDN *ABO ... Red blood cell breakdown, liver disease, infection, hypothyroidism, metabolic disorders[2][1]. ...
Hereditary elliptocytosis Sickle-cell disease List of hematologic conditions Wrong, O; Bruce, LJ; Unwin, RJ; Toye, AM; Tanner, ... Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 34: 153-159. doi:10.1016/j.meegid.2015.06. ... Rather, the defect lies in a protein known as the band 3 protein, which lies in the cell membrane itself. The band 3 protein ... The band 3 proteins aggregate on the cell membrane at the site of entry, forming a circular orifice that the parasite squeezes ...
Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease & complications from chemotherapy or ... Sickle cell disease Thalassemia Methemoglobinemia Anemias (lack of red blood cells or hemoglobin) Iron-deficiency anemia ... Rh disease (Rh D) ABO hemolytic disease of the newborn Anti-Kell hemolytic disease of the newborn Rhesus c hemolytic disease of ... T-cell prolymphocytic leukemia (T-PLL) B-cell prolymphocytic leukemia (B-PLL) Chronic neutrophilic leukemia (CNL) Hairy cell ...
Splenectomy for hematologic disease. The UCLA experience with 306 patients. Jul 1, 1984·Annals of Surgery·G MusserR W Busuttil ... Splenectomy for hematological diseases: The Qatif Central Hospital experience. Feb 6, 2007·Annals of Saudi Medicine·A H Al- ... Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression ... Eight patients had sickle cell disease, 14 beta-thalassemia and 9 had sickle cell thalassemia. All patients received ...
... including sickle cell disease, thalassemia and bone marrow failure. Learn how were improving hematopoietic cell ... Non-malignant bone marrow transplant for hematologic diseases. Our Blood and Marrow Transplant and Cellular Therapeutics team ... Diagnosis and Management of Sickle Cell Disease. The Hematology Program at Childrens Colorado is internationally recognized ... talks about the diagnosis and management of patients with sickle cell disease and briefly reviews new and emerging treatment ...
Griffin Rodgers spends most of his waking hours leading the National Institute of Diabetes and Digestive and Kidney Diseases ( ... Early Promise Observed With Lisaftoclax in Relapsed/Refractory CLL and Other Hematologic Malignancies - Targeted Oncology - ... stem-cell transplant regimen that is highly effective in reversing sickle cell disease in adults. The findings, based on a ... Rodgers grew up in New Orleans where he had three high school friends who became debilitated with sickle cell disease. Two of ...
Expert opinions for COVID-19 vaccination in patients with non-malignant hematologic diseases ... The fact that the majority of patients with Sickle Cell Disease and Thalassemia live in low resource settings these new ... 1st EHA European Sickle Cell Conference. 15th Annual Sickle Cell and Thalassemia & 1st EHA European Sickle Cell Conference. Mar ... The Abstract Book of the 15th Annual Sickle Cell and Thalassaemia, 1st EHA European Sickle Cell Conference, and 60th ...
Hematologic and Oncologic Emergencies. CHAPTER 103. Anemia. CHAPTER 104. Sickle Cell Disease ... Sexually Transmitted Diseases. SECTION 16. Dermatologic. CHAPTER 89. Petechiae and Purpura. CHAPTER 90. Superficial Bacterial, ... Thromboembolic Disease. SECTION 8. Nontraumatic Surgical Emergencies. CHAPTER 45. Late-Presenting Neonatal Surgical Emergencies ...
Sickle cell disease, hemophilia A & B, beta thalassemia. Source: Alliance for Regenerative Medicine ... non-small cell lung cancer, ovarian cancer, leukemia, lymphoma, skin cancer, brain cancer, hematologic malignancy, graft vs. ... For some diseases, it may be decades before we know if the clinical impact has been as profound and as durable as hoped for at ... Congestive heart failure, ischemic stroke, critical limb ischemia, ischemic heart disease, peripheral artery disease ...
Hematologic Diseases*Anemia. *Gaucher Disease. *Hemochromatosis. *Hemolytic-Uremic Syndrome. *Hemophilia. *Sickle Cell Disease ... All Rights Reserved,Home - About Us - Guidelines By Disease - Contact - Terms & Conditions ... Japanese Guidelines for Peptic Ulcer Disease. Japanese Society of Gastroenterology (JSGE) Evidence-based clinical practice ... for Gastrointestinal Endoscopy Guideline for the role of endoscopy in the management of patients with peptic ulcer disease - ...
... of a new gene therapy transplantation technique that could have future applications for treating neurodegenerative diseases. ... Immune cells defending the central nervous system (the so-called microglia) have a key role in many neurodegenerative diseases ... metabolic disease and might have future therapeutic applications for other neurodegenerative diseases in which microglia cells ... a heterogeneous group of hereditary metabolic diseases caused by a genetic mutation preventing cells from producing enzymes ...
Red blood cells from patient with sickle cell disease crispr therapeutics 2019 HIV ViaCyte, presented positive Phase. ... Francis Collins diseases using its proprietary CRISPR/Cas9 platform fetal. Therapies that it has helped pioneer -- CRISPR ( ... targeting CD70 for the treatment of solid tumors and hematologic malignancies. CRISPR… ... 2019, 8:22 … Crispr Therapeutics AG ... Red blood cells from patient with sickle cell disease crispr therapeutics 2019 HIV ViaCyte, presented positive Phase. ...
Hematologic Malignancies and Cellular Therapy. *Hematology. *Infectious Diseases. *Medical Oncology. *Nephrology. *Pulmonary, ... Phillips-Winn Memorial Medicine Grand Rounds: Sickle Cell Disease and the Science of Race. November 20, 2020 - 12:00pm to 1: ... His research examines the ways in which stigma impacts the illness experience of adults living with sickle cell disease, the ... Phillips-Winn Memorial Medicine Grand Rounds: Sickle Cell Disease and the Science of Race ...
Sedation & Analgesia: pharmacogenetics of codeine use in sickle cell disease, perioperative pain management after spinal ... hematologic, cardiovascular, and renal topics, plus ED management of children requiring critical care. Click the "Learn More" ... plus appropriate imaging modalities for select diseases and injuries.. $85.00 - Learn more & order: Pediatric Updates: Acute ... meningococcal disease, hepatitis A, B, and C, Marfan syndrome, deformational plagiocephaly, primary care for children with CHD ...
Sedation & Analgesia: pharmacogenetics of codeine use in sickle cell disease, perioperative pain management after spinal ... hematologic, cardiovascular, and renal topics, plus ED management of children requiring critical care. Click the "Learn More" ... plus appropriate imaging modalities for select diseases and injuries.. $85.00 - Learn more & order: Pediatric Updates: Acute ...
Sedation & Analgesia: pharmacogenetics of codeine use in sickle cell disease, perioperative pain management after spinal ... hematologic, cardiovascular, and renal topics, plus ED management of children requiring critical care. Click the "Learn More" ... plus appropriate imaging modalities for select diseases and injuries.. $85.00 - Learn more & order: Pediatric Updates: Acute ...
Sedation & Analgesia: pharmacogenetics of codeine use in sickle cell disease, perioperative pain management after spinal ... hematologic, cardiovascular, and renal topics, plus ED management of children requiring critical care. Click the "Learn More" ... plus appropriate imaging modalities for select diseases and injuries.. $85.00 - Learn more & order: Pediatric Updates: Acute ...
Sedation & Analgesia: pharmacogenetics of codeine use in sickle cell disease, perioperative pain management after spinal ... hematologic, cardiovascular, and renal topics, plus ED management of children requiring critical care. Click the "Learn More" ... plus appropriate imaging modalities for select diseases and injuries.. $85.00 - Learn more & order: Pediatric Updates: Acute ...
... of 5,230 general hospitals in a hospital and a college acceptance letter and you recently expanded one with sickle cell disease ... Trump administration has not yet overdosed but could potentially reduce chronic diseases, risky health behaviors, and ... and hematologic toxicities such as urgent end-of-life situations, clergy will be available in one sample collected and what ... Centers for Disease Control and Prevention (CDC) will provide an update on the coordinated federal effort to estimate the ...
Gamida Cell Presents Efficacy and Safety Results of Phase 3 Study of Omidubicel in Patients with Hematologic Malignancies at ... First in the nation, FDA-approved Phase II mesenchymal stem cell therapy for Parkinsons disease begins - Newswise - April 18th ... Novartis, Gates Foundation pursue a simpler gene therapy for sickle cell - STAT - February 17th, 2021 ... Zebrafish reveal regenerative protein that could inspire new treatments for muscle-wasting diseases and aging - FierceBiotech ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... New Insights in Inherited Hematologic Diseases. *Changing Workforce of Pediatric Hematology/Oncology ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ... 2019 Session , (2011) Gabapentin for Pain in Sickle Cell Disease: Results of a Randomized Phase II Clinical Trial ...
  • Plastic bronchitis is related mainly to respiratory, cyanotic cardiac (post-Fontan), and hematologic (sickle cell anemia) diseases. (cdc.gov)
  • Gonadotoxic treatments are also provided before bone marrow transplantation to treat benign hematologic diseases such as thalassemia major, aplastic anemia or sickle cell disease. (uclouvain.be)
  • Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models. (iu.edu)
  • Wagner also specializes in Fanconi anemia and the use of stem cells in epidermolysis bullosa. (umn.edu)
  • Dedicated to advancing research on the biological underpinnings of cancer, stem cell biology, sickle cell anemia, endothelial cell biology, and tumor immunology. (umn.edu)
  • 14 - 17 Previously, transfusional hemosiderosis has been recognized to play a significant role in the development of chronic liver disease in thalassemias and sickle cell anemia. (aappublications.org)
  • HCT is effective for a number of diseases including various hematologic malignancies, non-cancerous diseases including aplastic anemia, thalassemia, sickle cell anemia, and severe combined immunodeficiency ( 2 ). (frontiersin.org)
  • 21 Anemia of Kidney Disease. (issuu.com)
  • Inherited genetic alterations are responsible for a range of devastating hematologic diseases, including sickle cell anemia and other hemoglobinopathies, as well as bleeding disorders due to abnormalities of coagulation and platelet function. (hematology.org)
  • Predisposing risk factors for immediate allergic-type reactions include a previous adverse reaction, atopy, asthma, dehydration, heart disease, existing renal disease, hematologic disease (e.g., sickle-cell anemia), age less than 1 year or more than 65 years, and use of β-blockers or non-steroidal anti-inflammatory drugs. (cmaj.ca)
  • The aim of the present study was to investigate caries prevalence and socioeconomic factors in children with sickle cell anemia. (scielo.br)
  • This study was conducted in 160 children with sickle cell anemia aged 3 to 12 years attending the Center for Hematology in Recife, Brazil. (scielo.br)
  • Sickle cell anemia is a genetic disorder characterized by a mutant type of hemoglobin, called hemoglobin S (HbS), that causes the sickling of red blood cells. (scielo.br)
  • 1 Sickle cell anemia is the most common hereditary disease in Brazil and worldwide. (scielo.br)
  • Given the peculiarities of sickle cell anemia and its sequelae in the oral cavity, this study examined caries and socioeconomic factors in children with this disease. (scielo.br)
  • This sample consisted of 160 patients with a clinical and laboratory diagnosis of sickle cell anemia treated at the HEMOPE in Recife, Brazil. (scielo.br)
  • Since the publication of the Stroke Prevention Trial in Sickle Cell Anemia in 1998 and introduction of TCD screening, prophylactic blood transfusions, and hydroxyurea, the incidence of stroke has decreased. (hindawi.com)
  • Archer N, Galacteros F, Brugnara C. 2015 Clinical trials update in sickle cell anemia. (medscape.com)
  • Hematologic oncology incorporates such diseases as iron inadequacy anemia, hemophilia, sickle cell disease, the thalassemia, leukemia and lymphomas, and in addition to these there are cancers of different organs. (omicsonline.org)
  • Despite current therapies, sickle cell patients still experience frequent anemia and vaso-occlusive crises yearly. (uspharmacist.com)
  • Recently, three novel agents were approved to reduce the incidence of vaso-occlusive pain crises and/or anemia in sickle cell patients. (uspharmacist.com)
  • Polymerization also reduces the life span of HgS and therefore leads to hemolysis and anemia in sickle cell patients. (uspharmacist.com)
  • Vaso-occlusive pain crises and anemia are hallmark complications associated with sickle cell disease. (uspharmacist.com)
  • Hydroxyurea and blood transfusions have been the mainstays in the prevention of anemia and vaso-occlusive crises in sickle cell disease. (uspharmacist.com)
  • Recently, three novel agents ( TABLE 1 ) have been approved as an advancement to current therapies to reduce the incidence of vaso-occlusive crises and the risk of anemia among sickle cell patients. (uspharmacist.com)
  • PlasmaTech said it has licensed an AAV gene therapy and IP from the University of Minnesota to treat patients with Fanconi anemia (FA) disorder and other rare blood diseases. (wallstreetpit.com)
  • Sickle cell disease describes a group of inherited blood disorders characterized by chronic anemia, painful events, and various complications due to associated tissue and organ damage. (encyclopedia.com)
  • The most common and best-known type of sickle cell disease is sickle cell anemia, which is also called meniscocytosis, sicklemia, or SS disease. (encyclopedia.com)
  • This results in chronic anemia characterized by low levels of hemoglobin and decreased numbers of red blood cells. (encyclopedia.com)
  • This leads to the many symptoms and medical problems affecting children and adults with sickle cell disease, including pain, anemia, and bone, kidney, lung and neurologic problems. (scinfo.org)
  • The double-blind trial evaluated the efficacy and safety of pharmaceutical-grade L-glutamine administered twice daily by mouth, as compared with placebo, in reducing the frequency of pain crises among patients with sickle cell anemia or sickle β 0 -thalassemia and a history of two or more pain crises during the previous year. (scinfo.org)
  • In addition to blood cell cancers, hematologic diseases include rare genetic disorders, anemia, conditions related to HIV, sickle cell disease, and complications from chemotherapy or transfusions. (nih.gov)
  • Common cases include lymphoma, leukemia, autoimmune hematologic disorders, and complications from sickle cell disease. (iu.edu)
  • These include common disorders, such as diabetes mellitus and alcoholic liver disease, and classic disorders of immunosuppression, including human immunodeficiency virus (HIV) infection. (oncologynurseadvisor.com)
  • By combining these approaches, Dr. Machado seeks to gain novel insights into the pathogenesis and treatment of these complex lung disorders, which would hopefully lead to an improvement in the morbidity and mortality associated with sickle cell disease and pulmonary hypertension. (iu.edu)
  • Data will focus on a range of disease areas, including breast cancer, lung cancer, melanoma and sickle cell disease, as well as leukemias, other hematologic disorders and solid tumors. (novartis.com)
  • The other hematologic disorders were lymphoproliferative disorders: macroglobulinemia, chronic lymphocytic lymphoma, other lymphomas (including low-grade B-cell and diffuse large B-cell lymphoma), and cutaneous T-cell lymphoma. (medscape.com)
  • In these pages, you will find updated information on hematopoietic stem cell disorders, multiple myeloma, bleeding disorders, hematologic issues in pregnancy, and other hematologic topics. (issuu.com)
  • Table of Contents Hematopoietic Stem Cells and Their Disorders Overview. (issuu.com)
  • Previous therapeutic approaches for these disorders have included transplantation to replace hematopoietic stem cells or gene therapy using viral vectors to express normal copies of the affected gene in hematopoietic cells. (hematology.org)
  • As an experimental tool, this system has tremendous power to help researchers develop and manipulate experimental models of benign and malignant hematologic disorders. (hematology.org)
  • Emerging data attest to the ability of the CRISPR/Cas9 system to correct hematologic disorders, with proof-of-principle data for correcting β-thalassemia in stem cells. (hematology.org)
  • Ideal targets for these gene correction strategies are hematologic disorders such as hemoglobinopathies and coagulation disorders such as hemophilia, since existing treatment approaches have shown that only partial restoration of gene function is required to ameliorate the disease, and hematopoietic progenitors that are corrected can be easily re-transfused into the patient. (hematology.org)
  • The gene correction strategies developed for inherited disorders will likely also be attractive for other hematologic diseases, including autoimmune disorders (e.g., lupus, rheumatoid arthritis, type I diabetes), as well as for transplant rejection (either hematopoietic stem cell or solid organ transplants). (hematology.org)
  • While genome editing technology represents a highly promising area to advance the future of therapy for hematologic disorders, critical questions must be addressed to effectively translate this approach into clinical use. (hematology.org)
  • The exclusion criteria were other systemic diseases, psychiatric or neurological disorders, or other factors that precluded oral examinations. (scielo.br)
  • Sickle cell disease (SCD) is one of the most prevalent hematological genetic disorders, which could affect multiple organ systems, including the central nervous system (CNS). (hindawi.com)
  • Given the importance of the intracellular redox state in determining a cell's fate, and the increasing evidence that perturbations in the redox state are associated with cancer and various inflammatory disorders as well as aging, FRET-based redox sensors offer significant promise for understanding molecular mechanisms underlying human health and disease. (innovations-report.com)
  • Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Altered redox status is a hallmark of many diseases ranging from neurological disorders, such as Alzheimer's Disease, to hematologic disorders such as Sickle Cell Disease. (innovations-report.com)
  • There are many diseases and disorders that disproportionately affect the health of underserved populations in the United States. (nih.gov)
  • The present invention also relates to purified preparations of embryonic stem cells and for uses of embryonic stem cells in treating a wide variety of conditions, diseases and disorders. (google.es)
  • This invention relates to the in vitro expansion of undifferentiated embryonic stem cells, to purified cultures of expanded embryonic stem cells, and to the use of embryonic stem cells in the treatment of a wide variety of diseases, conditions and disorders. (google.es)
  • ABSTRACT: Sickle cell disease is a group of inherited blood disorders in which patients are born with sickled hemoglobin. (uspharmacist.com)
  • Sickle cell disease is a group of inherited red blood cell disorders in which patients inherit two defective hemoglobin genes. (uspharmacist.com)
  • Sickle cell disease encompasses a group of disorders in which at least one HgS allele is present. (uspharmacist.com)
  • 3 Other common disorders include sickle-hemoglobin C disease and sickle beta thalassemia, both of which are caused when a patient inherits one HgS allele and another abnormal beta-globin chain mutation. (uspharmacist.com)
  • He also served as a research fellow with CHOP's Center for Fetal Research for four years, investigating the role of in utero bone marrow and stem cell transplantation for the management of congenital hematologic disorders such as sickle cell disease. (chop.edu)
  • however, they stated further workup should be pursued to investigate for underlying vascular, metabolic, hematologic, and immunologic disorders. (mdedge.com)
  • Because sickle cell diseases are characterized by the rapid loss of red blood cells as they enter the circulation, they are classified as hemolytic disorders, "hemolytic" referring to the destruction of the cell membrane of red blood cells resulting in the release of hemoglobin. (encyclopedia.com)
  • Hematologic diseases, disorders of the blood and blood-forming organs, afflict millions of Americans. (nih.gov)
  • An open label, prospective, randomized cross-over phase II study in up to 60 sickle cell patients who are either homozygous for Hb S or have HbSB0 thalassemia. (clinicaltrials.gov)
  • This disease, in addition to thalassemia, is responsible for 3.4% of all deaths of children under five years of age. (scielo.br)
  • These data are promising for patients living with beta-thalassemia major and severe sickle cell disease, two devastating, genetically-based hematologic diseases that have a profound impact on both quality of life and life expectancy," said Professor Cavazzana. (businesswire.com)
  • We are excited that the promising early results for LentiGlobin in beta-thalassemia major are now extending to the first treated patient with severe sickle cell disease. (businesswire.com)
  • These data are promising for patients living with beta-thalassemia major and severe sickle cell disease, two devastating, genetically-based hematologic diseases that have a profound impact on both quality of life and life expectancy," stated Professor Cavazzana, Marina Cavazzana, M.D., Ph.D., lead investigator of the HGB-205 study. (wallstreetpit.com)
  • My area of special interest is solid tumors, especially germ cell tumors and rare cancers and hemoglobinopathies including sickle cell disease and thalassemia. (yalecancercenter.org)
  • The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). (broadinstitute.org)
  • In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that predict prognosis and response to therapies in MDS patients, characterized a pre-malignant state of hematopoietic cells, and derived the molecular ontogeny of genetic lesions in myeloid malignancies. (broadinstitute.org)
  • In addition to human genetic studies, the lab has elucidated the biological basis of transformation of hematopoietic cells by these somatic mutations and developed novel in vivo models to study myeloid malignancies. (broadinstitute.org)
  • The lab employs genetic and small molecule screens to identify novel therapeutic targets and small molecules for the treatment of hematologic malignancies and sickle cell disease. (broadinstitute.org)
  • 5 , 11 - 13 Recently, a secondary iron overload has also been reported to be a contributing factor to liver disease in the treatment of hematologic malignancies and after allogeneic or autologous bone marrow transplantation. (aappublications.org)
  • Apart from hematologic malignancies such as leukemia, lymphoma, and myeloma, HCT showed positive yet limited effects in patients taking chemotherapeutic regimens for solid tumors. (frontiersin.org)
  • A lot of our scientists are studying the immune regulation of viral infections, there are thromboses in patients with COVID-19, convalescent plasma has emergency use authorization, and then of course we have a large population of immunocompromised patients - people with hematologic malignancies or sickle cell disease , and patients [who have undergone] stem cell transplant," Lee said. (healio.com)
  • Children with sickle cell disease may have their quality of life affected by oral alterations. (scielo.br)
  • This is a prospective pilot study of matched-related donor allogeneic stem cell transplantation in adults with severe sickle cell disease using a matched-sibling PBSC graft with a non-myeloablative conditioning regimen (Alemtuzumab). (clinicaltrials.gov)
  • Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease. (springer.com)
  • The steady rise and high-level of HbA T87Q production in our patient with severe sickle cell disease is cause for optimism as we expect levels of anti-sickling hemoglobin of 30 percent or more could significantly improve and potentially eliminate the serious and life-threatening complications associated with sickle cell disease. (businesswire.com)
  • With the treatment of the first patient with severe sickle cell disease in the HGB-206 study, we look forward to gaining increasing clarity on the potential clinical benefit of LentiGlobin for patients with severe sickle cell disease. (businesswire.com)
  • Patients with intact immune systems generally have asymptomatic or self-limited acute disease and do not develop severe manifestations, such as transient aplastic crisis or chronic infection. (clinicaladvisor.com)
  • Severe cold agglutinin disease and cryoglobulinemia secondary to a monoclonal anti-Pr2 IgM lambda cryoagglutinin. (medscape.com)
  • Homozygous disease (HbSS), usually called sickle cell anaemia (SCA), is the most common and severe type of disease in most populations. (bmj.com)
  • 2 Numbers are increasing, and sickle cell disease is thought to be the most common severe genetic disease in the United Kingdom and France, with 10 000-15 000 patients in each country. (bmj.com)
  • HSCT was found to have an 87% curative rate among sickle cell patients with severe disease. (uspharmacist.com)
  • Several factors such high cost, severe side effects post-transplantation, risk of death, and the requirement for an exact donor match limit use among sickle cell patients. (uspharmacist.com)
  • Hematologic oncology is determination, treatment and anticipation of blood diseases (hematology) and cancer (oncology) and research into them. (omicsonline.org)
  • Safe neutraceuticals are of major importance to the sickle cell community," said Elliott Vichinsky , MD, Director of Hematology/Oncology at the Northern California Sickle Center at UCSF Benioff Children's Hospital Oakland. (scinfo.org)
  • Lee acknowledged the interactions between hematology and SARS-CoV-2, and the prominent role of the disease in research presented at the ASH meeting. (healio.com)
  • NIDDK-supported hematology researchers work in many different areas, from developing drugs to support people who receive multiple blood transfusions, to laboratory research to better understand the normal and abnormal function of blood cells. (nih.gov)
  • The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of SHP655 in participants with baseline health sickle cell disease (SCD) and SCD with acute vaso-occlusive crisis (VOC). (clinicaltrials.gov)
  • Red cell storage time and physical changes in blood are associated with acute transfusional changes in endothelial function. (bloodjournal.org)
  • Common cases include acute and chronic hepatitis, complications of cirrhosis, end-stage liver disease, and acute liver failure. (iu.edu)
  • Acute lymphoblastic leukemia (ALL) was a fatal disease until the early to mid-1960s. (aspho.org)
  • Liver disease associated with acute lymphoblastic leukemia (ALL) has been studied intensively in recent decades. (aappublications.org)
  • Sickle cell disease is characterised by unpredictable episodes of acute illness, progressive organ damage, and a lack of effective treatments. (bmj.com)
  • The combination of a bone scan and a bone marrow scan has been used to differentiate acute osteomyelitis from bone infarcts in patient with sickle cell, since the clinical presentation of these 2 conditions may be very similar. (medscape.com)
  • De D. Acute nursing care and management of patients with sickle cell. (medscape.com)
  • This work demonstrates a simple method for extending AFM mechanical property measurements to nonadherent cells and characterizes properties of human leukemia cells that may contribute to leukostasis, a complication associated with acute leukemia. (jove.com)
  • Acute lymphoblastic and acute myeloid leukemia cells were incubated with standard induction chemotherapy, and individual cell stiffness was tracked with atomic force microscopy. (jove.com)
  • All types of sickle cell disease are caused by a genetic change in hemoglobin, the oxygen-carrying protein inside the red blood cells. (encyclopedia.com)
  • Lenalidomide and related drugs modulate the function of an E3 ubiquitin ligase, inducing drug-dependent degradation of specific substrates that are essential for the survival of multiple myeloma and MDS cells, representing the first drugs that bind and modulate the function of an E3 ubiquitin ligase. (broadinstitute.org)
  • Dr. Machado's laboratory focuses on the study of pulmonary hypertension and pulmonary complications of sickle cell disease. (iu.edu)
  • Dr. Machado's clinical interests include pulmonary hypertension and pulmonary complications of sickle cell disease. (iu.edu)
  • Diagram showing the pathophysiology and some of the major clinical complications of sickle cell disease. (bmj.com)
  • Current treatment options and these novel agents can be used to successfully manage these two major complications of sickle cell disease. (uspharmacist.com)
  • 5 Despite the efficacy of current therapeutic options, sickle cell patients experience an average of three pain crises yearly, and 96% of hospitalizations of sickle cell patients are due to vaso-occlusive crisis. (uspharmacist.com)
  • Sickle cell disease (SCD) is a single gene defect resulting from a point mutation in the β-globin gene, causing hemoglobin (Hb) to polymerize when deoxygenated. (bloodjournal.org)
  • Immature red blood cells produce globin proteins, key components of hemoglobin, which carry oxygen in red blood cells from the lungs to the rest of the body. (nih.gov)
  • Identification of looping factors such as Ldb1 and delineation of the various components required for proper β-globin transcription may help the development of new ways to treat hematologic diseases, such as sickle cell disease, by reactivating dormant hemoglobin genes. (nih.gov)
  • Sickle cell disease is caused by a mutation in which glutamine is replaced with valine at the sixth position of the beta globin gene (HBB) and is characterized by the production of sickled hemoglobin (HgS). (uspharmacist.com)
  • Upon deoxygenation of hemoglobin, HgS undergoes polymerization, which damages the blood cell. (uspharmacist.com)
  • The red blood cells of affected individuals contain a predominance of a structural variant of the usual adult hemoglobin. (encyclopedia.com)
  • This variant hemoglobin, called sickle hemoglobin, has a tendency to polymerize into rod-like structures that alter the shape of the usually flexible red blood cells. (encyclopedia.com)
  • Sickle hemoglobin is the result of a genetic change in the beta globin component of normal adult hemoglobin. (encyclopedia.com)
  • As a result of this change, sickle hemoglobin has unique properties in comparison to the usual type of adult hemoglobin. (encyclopedia.com)
  • These individuals make both the usual adult hemoglobin and sickle hemoglobin in roughly equal proportions, so they do not experience any health problems as a result of having the trait. (encyclopedia.com)
  • It is hereditary haemolytic anaemia in which the red blood cell is oval-shaped. (wikipedia.org)
  • Unlike those with the Leach phenotype of common hereditary elliptocytosis (see above), there is a clinically significant reduction in both disease severity and prevalence of malaria in those with SAO. (wikipedia.org)
  • Our hope in sharing the results of this data from the New England Journal of Medicine is to increase awareness of sickle cell disease, a lifelong hereditary blood disorder which commonly affects those of African descent, as well those from Central and South America and people of Middle Eastern, Asian, Indian and Mediterranean descent. (scinfo.org)
  • Underlying conditions were classified according to the 2012 Report of the Committee on Infectious Diseases and 2013 recommendations by the Advisory Committee on Immunization Practices. (aappublications.org)
  • Graphic icons highlight new and emerging infectious diseases, important clinical alerts, health and safety tips, newsworthy developments and research, and the evidence behind certain facts. (r2library.com)
  • Despite promising data that have emerged on COVID-19 vaccine candidates, a return to normal "carefree" life is likely years out, according to Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases. (healio.com)
  • Endari, is the first approved treatment for sickle cell disease in pediatric patients 5 years of age and older and the first in nearly 20 years for adults," said study co-author Yutaka Niihara, MD, CEO and founder of Emmaus, which produces the product. (scinfo.org)
  • Hydroxyurea and blood transfusions have been the gold standard of therapy for the management of sickle cell disease. (uspharmacist.com)
  • Hydroxyurea is an antimetabolite proven to reduce the incidence of vaso-occlusive pain crises and the need for blood transfusions in sickle cell patients. (uspharmacist.com)
  • The study showed that whether administered alone or with hydroxyurea, L-glutamine reduced the frequency of sickle cell pain crises by 25 percent (a median of three events per patient in the L-glutamine group and four in the placebo group) and hospitalizations by 33 percent (a median of two hospitalizations in the L-glutamine group and three in the placebo group). (scinfo.org)
  • Studies have shown that up to 98 percent of patients with Sickle Cell Disease have a vitamin D deficiency, defined as a 25-hydroxyvitamin D level (25(OH)D) less than or equal to 20 ng/mL. (clinicaltrials.gov)
  • Thus, the main purpose of this study is to find the amount of nutritional vitamin D that needs to be taken by patients with sickle cell disease in order to correct vitamin D deficiency. (clinicaltrials.gov)
  • This is an observational cohort study to follow vitamin D levels over time in patients with sickle cell disease receiving doses of vitamin D as part of their clinical care for vitamin D deficiency. (clinicaltrials.gov)
  • This non-myeloablative therapy uses doses of chemotherapy and radiation to weaken (but not destroy) the patients bone marrow and immune system, while still allowing their body to accept the donor's stem cells. (clinicaltrials.gov)
  • Patients will then be assessed for discharge either to home or admitted to the hospital for further treatment depending on their disease severity. (clinicaltrials.gov)
  • Young hepatologists will gain expertise on the clinical assessment of chronic liver disease and how to manage and treat these patients. (cpduk.co.uk)
  • In patients with pulmonary hypertension due to lung disease or left heart disease, treatment should focus on optimizing comorbid conditions. (aafp.org)
  • Use of vasodilator therapies in patients with pulmonary hypertension due to lung disease or left heart disease is potentially harmful and not recommended. (aafp.org)
  • PROCRIT is contraindicated in patients with uncontrolled hypertension or with known hypersensitivity to albumin (human) or mammalian cell-derived products. (bio-medicine.org)
  • We specialize in the evaluation and treatment of patients referred for blood and marrow stem cell transplants. (moffitt.org)
  • There were no statistically significant differences in the total scores of the Child Perceptions Questionnaires or domain scores comparing sickle cell disease patients to control subjects. (scielo.br)
  • This study will examine whether the drug sildenafil can lower blood pressure in the pulmonary artery (the blood vessel that leads from the heart to the lungs) in patients with sickle cell disease and pulmonary hypertension (high blood pressure in the lungs). (unt.edu)
  • Patients 12 years of age and older with sickle cell disease and pulmonary hypertension may be eligible for this study. (unt.edu)
  • His research has contributed to the discovery of pulmonary hypertension as a major risk factor for death in adult patients with sickle cell disease. (iu.edu)
  • Committed to providing the highest quality care based on cutting edge research to patients with cancer or non-malignant hematologic diseases such as sickle cell disease. (umn.edu)
  • Chemical and genetic inhibition of NLK increases erythroid expansion in mouse and human progenitors, including bone marrow cells from DBA patients. (stanford.edu)
  • Hematopoietic cell transplantation (HCT) is a proven therapeutic approach for patients suffering from various hematologic and immunologic diseases ( 1 ). (frontiersin.org)
  • 7,8 Dentists play an important role in preventing complications and improving the quality of life of patients with sickle cell disease 9 because these patients are more susceptible to infections and periodontal disease. (scielo.br)
  • Most patients with the disease have been shown to have mutations in the HFE gene with the predominant mutation being a missense mutation, C282Y. (nih.gov)
  • This review aims to provide an evidence based update on how to manage patients with this disease in the community. (bmj.com)
  • DOXIL is indicated for the treatment of patients with ovarian cancer whose disease has progressed or recurred after prior platinum based therapy. (bio-medicine.org)
  • However, areas of marrow proliferation, which are common in patients with sickle cell, would also demonstrate increased activity on 111 In WBC scans. (medscape.com)
  • Olujohungbe A, Howard J. The clinical care of adult patients with sickle cell disease. (medscape.com)
  • Imaging of musculoskeletal manifestations in sickle cell disease patients. (medscape.com)
  • Mauriello A, Giacobbi E, Saggini A, Isgrò A, Facchetti S, Anemona L. Histological features of bone marrow in paediatric patients during the asymptomatic phase of early-stage Black African sickle cell anaemia. (medscape.com)
  • For example, the number of embryonic stem cells used for treating patients according to the practice of the instant invention requires the use of a single fetus per patient as a source of the cells. (google.es)
  • By contrast, expanding a population of embryonic stem cells while maintaining the cells in an undifferentiated and pluripotent state would allow several thousand patients to be treated with cells isolated from a single fetus. (google.es)
  • This includes the evaluation of new patients, those presenting for chemotherapy, those presenting for complications of their disease, as well as those patients presenting for routine follow-up or long-term follow-up. (iu.edu)
  • it occurs when a patient inherits both HgS alleles and accounts for 60% to 70% of patients with sickle cell disease. (uspharmacist.com)
  • Hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for patients with sickle cell disease. (uspharmacist.com)
  • This licensing transaction expands our commitment to building a leadership position in the gene therapy space, with a focus on developing therapies for patients with rare diseases," said in a press release Steven Rouhandeh, Executive Chairman of PlasmaTech. (wallstreetpit.com)
  • We plan to leverage the unique capabilities of the CRISPR-Cas9 gene editing platform technology to build a robust product pipeline to address the unmet needs of patients that may have one of a variety of blood diseases. (wallstreetpit.com)
  • CSF Benioff Children's Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease (SCD). (scinfo.org)
  • The paper, "A Phase 3 Trial of L-Glutamine in Sickle Cell Disease," documented the effects of taking Endari™, a prescription-grade, pharmaceutical form of L-glutamine, as compared to placebo, for 230 patients aged 5 to 58 years of age with sickle cell disease. (scinfo.org)
  • This study validated research on the safety of pharmaceutical grade L-glutamine which has antioxidant properties that improves the NAD redox potential in sickle cell patients. (scinfo.org)
  • It is important for patients to know that they have a treatment option for this debilitating disease. (scinfo.org)
  • Immunocompromising conditions (32.7%) and chronic respiratory diseases (22.4%) were most common. (aappublications.org)
  • 1. Chronic disease - epidemiology. (who.int)
  • 2. Chronic disease - therapy. (who.int)
  • 3. Chronic disease - prevention and control. (who.int)
  • 2.2 Effect of chronic disease on psychosocial development. (who.int)
  • Among children, and especially among adolescents, increased life expectancy due to improvements in nutrition, hygiene and control of infec- tious diseases are producing an epidemiological transition in which noncommunicable diseases includ- ing chronic diseases and disability are emerging as major health problems. (who.int)
  • Sickle cell disease in children: chronic complications and search of predictive factors for adverse outcomes. (mdedge.com)
  • 4. Leukemia stem cell (LSC) fate choice and development of chemical probe to target LSC as therapeutics. (uic.edu)
  • Force Microscopy of Nonadherent Cells: a Comparison of Leukemia Cell Deformability Biophysical Journal. (jove.com)
  • We apply this technique to compare the deformability of human myeloid and lymphoid leukemia cells and neutrophils at low deformation rates, and we find that the cells are well described by an elastic model based on Hertzian mechanics. (jove.com)
  • Chemotherapy Exposure Increases Leukemia Cell Stiffness Blood. (jove.com)
  • Here we report the effect of chemotherapy on leukemia cell mechanical properties. (jove.com)
  • AUR is most often caused by bladder outflow obstruction, which commonly occurs in aging men due to benign prostatic hyperplasia (BPH) and accounts for the observed epidemiologic pattern of disease. (auanet.org)
  • The term benign hematologic disease describes a variety of noncancerous blood diseases. (uhhospitals.org)
  • The NIDDK also supports research in the biology of adult blood stem cells, which are needed for bone marrow transplants and may have broader application in gene therapy research. (nih.gov)
  • The diagnoses are further categorized into hematologic, infectious, genodermatoses, and autoimmune etiologies to help the dermatologist deduce the accurate diagnosis in this unique patient population. (mdedge.com)
  • The primary defect in SAO differs significantly from other forms of elliptocytosis in that it is a defect in the gene coding for a protein that is not directly involved in the cytoskeleton scaffolding of the cell. (wikipedia.org)
  • The inheritance of one sickle cell gene from each parent (SS) is the most common and the severest form of the disease, affecting around 280,000 newborns per year. (scielo.br)
  • Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. (medscape.com)
  • Using erythroid precursor cells (cells that develop into normal red blood cells) to study the β-globin gene locus transcription process, researchers showed for the first time that the protein Ldb1 is a key looping factor involved in long-range regulation of gene transcription. (nih.gov)
  • However, great progress has been made in addressing these issues, and current gene transfer methods have demonstrated improved safety and long-term efficacy in correcting a number of monogenic diseases. (hematology.org)
  • In a CF mouse model, a modifier gene was detected on mouse chromosome 7 that contributed to fatal intestinal disease. (nih.gov)
  • The identification of this modifier gene could lead to better understanding of the factors underlying the clinical heterogeneity in CF. Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common Mendelian diseases in humans and a major cause of renal failure. (nih.gov)
  • Sickle cell disease is a recessive condition, caused by a mutation in the β globin gene, which changes the sixth amino acid from glutamic acid to valine. (bmj.com)
  • Parallel with this advance is the emerging recognition that the intracellular redox environment exerts a profound influence on the normal cellular processes of DNA synthesis, enzyme activation, selective gene expression, cell cycle progression, proliferation, differentiation, and apoptosis. (innovations-report.com)
  • In utero gene editing for monogenic lung disease. (chop.edu)
  • Carriers of the sickle cell gene are said to have sickle cell trait. (encyclopedia.com)
  • The sickle cell form of the beta globin gene results from the substitution of a single DNA nucleotide, or genetic building-block. (encyclopedia.com)
  • Individuals who have sickle cell trait (called sickle cell carriers) have one normal beta globin gene and one sickle cell gene. (encyclopedia.com)
  • Participant has a diagnosis of osteonecrosis and a hematologic malignancy or sickle cell disease. (stjude.org)
  • Tricuspid regurgitant (TR) jet velocity and its relationship to pulmonary hypertension has been controversial in sickle cell disease (SCD). (bloodjournal.org)
  • FMD is strongly correlated with tricuspid regurgitant (TR) jet velocity, cardiac index, and myocardial performance index in children with primary pulmonary hypertension, reinforcing its role in pulmonary vascular disease. (bloodjournal.org)
  • His efforts have led to the identification of novel genetic modifiers and biochemical and molecular biomarkers in sickle cell disease and pulmonary hypertension. (iu.edu)
  • His laboratory also utilizes animal models of sickle cell disease and pulmonary hypertension to investigate the role of the pulmonary vascular endothelium in regulating vasomotor tone, permeability, vascular proliferation and apoptosis. (iu.edu)
  • To determine whether response to propranolol therapy is associated with polymorphisms in genes encoding the proteins involved in the upregulation of Sickle Red Blood Cell (SS RBC) adhesion by epinephrine. (clinicaltrials.gov)
  • Furthermore key opinion leaders in the field will discuss and define emerging challenges rare and frequent liver diseases, in special situations or medical therapy. (cpduk.co.uk)
  • It is a major advance in therapy for sickle cell disease and offers families safe, new therapeutic options. (scinfo.org)
  • Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapeutic approach for various hematologic and immunologic ailments. (frontiersin.org)
  • The stickiness of SS RBC will be evaluated by a well-established in vitro assay of adhesion of SS RBCs to cultured endothelial cells using a flow chamber. (clinicaltrials.gov)
  • Estrogen stimulates von Willebrand factor production by cultured endothelial cells. (springer.com)
  • Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death. (iu.edu)
  • In hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome (HUS), pathological biophysical interactions among blood cells, endothelial cells, and soluble factors lead to microvascular occlusion and thrombosis. (jci.org)
  • Cystic Fibrosis is one of the most common, life-limiting genetic diseases in children. (nih.gov)
  • Stem cell transplantation recipients will be given Alemtuzumab, which is a non-myeloablative pre-transplant conditioning regimen. (clinicaltrials.gov)
  • Alemtuzumab will be given 7 days prior to stem cell infusion at 0.03 mg/kg IV, 6 days prior to stem cell infusion at 0.1 mg/kg IV, and 5 thru 3 days prior to stem cell infusion at 0.3 mg/kg IV. (clinicaltrials.gov)
  • Sickle cell patient receives sibling donor peripheral blood stem cell transplant with non-myeloablative pre-transplant conditioning. (clinicaltrials.gov)
  • Evaluating reversal of Hb S % to that of the donor's phenotype, in recipients of HLA matched-sibling peripheral blood - hematopoietic stem cell transplantation (HSCT) with NMA conditioning regimen. (clinicaltrials.gov)
  • 2. Cord blood stem cell expansion using epigenetic modifier to understand biology of stem cell fate. (uic.edu)
  • Dating back to the world's first successful bone marrow transplant in 1968, the University of Minnesota Medical School has been, and continues to be, a leader in stem cell research and regenerative medicine-a field of innovative therapies that enable the body to heal itself. (umn.edu)
  • As the first such institute in the nation, our Stem Cell Institute is a national leader in the field of stem cell research. (umn.edu)
  • Researchers and faculty explore the science of stem cell biology, respond to the medical needs of today, and educate the researchers of tomorrow. (umn.edu)
  • 9 Hematopoietic Stem Cell Transplantation. (issuu.com)
  • Although human embryonic stem cells can be isolated from aborted fetuses and/or embryos produced by in vitro fertilization techniques on an as-needed basis, alternate sources, such as cultured embryonic stem cell lines, are preferred both for ethical and economic reasons. (google.es)
  • Treatment appears to reduce the likelihood of progression to pneumonia and death in risk groups like pregnant women, and in severely immunocompromised hosts, including hematopoietic stem cell (HSCT) and solid organ transplant recipients. (renalandurologynews.com)
  • The chemotherapy protocols for childhood ALL have intensified, indicating the need for more frequent red blood cell (RBC) transfusions, which can predispose to iron overload and liver siderosis. (aappublications.org)
  • Genetic modifiers for severity of the renal disease have been mapped in two animal models of PKD but have not been yet been studied in humans. (nih.gov)
  • For example, few studies have examined the increased prevalence of caries in individuals with sickle cell disease. (scielo.br)
  • High bone mineral density in sickle cell disease: Prevalence and characteristics. (medscape.com)
  • 2 Sickle cell disease also has a global impact, with a high prevalence among people of sub-Saharan Africa, South America, the Caribbean, Central America, Saudi Arabia, India, and the Mediterranean. (uspharmacist.com)
  • the need for red blood cell (RBC) transfusion. (bio-medicine.org)
  • Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. (stjude.org)
  • Sickle cell disease (SCD) is an inherited autosomal recessive blood disease. (scielo.br)
  • 3 , 4 Repeated Hb polymerization also damages the red blood cell (RBC) structural integrity by mechanical and oxidative stress, lowering RBC deformability and increasing RBC adhesion properties. (bloodjournal.org)
  • The Medical School's blood and marrow transplant research has a legacy of changing perspectives around what is medically possible for children battling some of the world's most complex, life-threatening diseases. (umn.edu)
  • TIS correlated most significantly positively with serum ferritin (r S = 0.899), transferrin iron saturation (r S = 0.764), and the amount of transfused red blood cells (r S = 0.783). (aappublications.org)
  • Two studies have advanced our understanding of the transcriptional regulation of a set of red blood cell genes call globin genes, and of how these genes are turned on and off. (nih.gov)
  • Production of globin proteins is a highly regulated process to ensure that these genes are turned on ("expressed") or off at appropriate times during the development of red blood cells from their precursors in the bone marrow. (nih.gov)
  • Indium-111 ( 111 In) white blood cell (WBC) scanning is useful to diagnose osteomyelitis, which appears as an area of increased activity within bone. (medscape.com)
  • For example, hematopoietic stem cells will give rise to red blood cells, white blood cells, and platelets, while neuronal stem cells will give rise to the various types of nerve cells. (google.es)
  • 4 As a result, a more rigid, adhesive HgS is produced that sticks to other blood cells and endothelium and in turn occludes small blood vessels. (uspharmacist.com)
  • Sickle cells have a shorter life span than normally shaped red blood cells. (encyclopedia.com)
  • Sickle cells are also less flexible and stickier than normal red blood cells, and can become trapped in small blood vessels preventing blood flow. (encyclopedia.com)
  • In fact, sickle cell trait is protective against malaria, a disease caused by blood-borne parasites transmitted through mosquito bites. (encyclopedia.com)
  • Although traces of blood in the urine and difficulty in concentrating the urine can occur, neither represents a significant health problem as a result of sickle cell trait. (encyclopedia.com)
  • Sickle cell disease is a genetic blood disorder that causes a distortion in the shape of red blood cells. (scinfo.org)
  • Pubmed ID: 17179225 Deformability of blood cells is known to influence vascular flow and contribute to vascular complications. (jove.com)
  • Medications for hematologic diseases have the potential to modulate these complications if they alter blood cell deformability. (jove.com)
  • In addition, NIDDK responds to questions and provides health information about blood diseases to people with blood diseases and to their families, health professionals, and the public. (nih.gov)
  • It does not consider sickle cell trait, which is largely asymptomatic. (bmj.com)
  • Unlike sickle cell disease, sickle cell trait does not cause health problems. (encyclopedia.com)
  • According to a widely accepted theory, the genetic mutation associated with the sickle cell trait occurred thousands of years ago. (encyclopedia.com)
  • As populations migrated, so did the sickle cell trait. (encyclopedia.com)
  • Today, approximately one in 12 African Americans has sickle cell trait. (encyclopedia.com)
  • and genetic kidney diseases such as polycystic kidney disease. (nih.gov)
  • The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) seeks research to improve understanding of the causes of high priority diseases in the United States and to develop and test more effective interventions for reducing/eliminating health disparities. (nih.gov)
  • The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) seeks research to improve understanding of the causes of disparities in health and disability in the United States and to develop and test more effective interventions for reducing/eliminating health disparities directly related to the scientific areas within the mission of the NIDDK http://www2.niddk.nih.gov/Research/ScientificAreas/default.htm . (nih.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Of the oral alterations, there was a significant difference in the oral health-related quality of life between adolescents with sickle cell disease and controls only in relation to malocclusion. (scielo.br)
  • Under controlled flow conditions, the model enabled quantitative investigation of how biophysical alterations in hematologic disease collectively lead to microvascular occlusion and thrombosis. (jci.org)
  • However, some people will develop osteoporosis, meaning the bone cells that are dissolved won't be replaced [8] . (kidspot.com.au)
  • Osteoporosis is dubbed the 'silent disease' because bone loss occurs gradually and normally without symptoms [10] . (kidspot.com.au)
  • Tuna IS, Tarhan B, Escobar M, Albayram MS. T2-blackout effect on DWI as a sign of early bone infarct and sequestration in a patient with sickle cell disease. (medscape.com)
  • Alghamdi A. Recurrent orbital bone sub-periosteal hematoma in sickle cell disease: a case study. (medscape.com)
  • 1 . A method for accelerating the healing of a bone fracture, the method comprising the step of injecting embryonic stem cells into the subperiostium of the fractured bone. (google.es)
  • Striking variations are seen in clinical expression of genetic diseases, presumably due to differences in the genetic makeup and environmental exposure of the individual. (nih.gov)
  • Investigators described approaches to identifying genetic modifiers and presented the clinical evidence for the presence of significant modifiers for several genetic diseases. (nih.gov)
  • Additional information on the presentations can be found in the abstracts at http://www.niddk.nih.gov/fund/other/genetic/gmmt/abstract-book.pdf Many genetic diseases within the mission of NIDDK have evidence for clinically significant genetic modifiers. (nih.gov)
  • Embryonic stem cells have no antigenicity and thus are well-suited for therapies involving introduction of stem cells into the human body. (google.es)
  • 10 There has been a desperate need for additional therapies to increase life expectancy and to reduce complications associated with sickle cell disease. (uspharmacist.com)
  • An AE can therefore be any unfavorable and unintended sign (including a clinically significant laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not causality is suspected (ICH Guidance E2A 1995). (clinicaltrials.gov)
  • Since cancer treatments can damage the SGS, our laboratory is currently developing an artificial neoplastic cell free testis. (uclouvain.be)
  • Most of the currently used therapeutic regimens for GVHD are based on inhibiting the allogeneic T cell response or T-cell depletion (TCD). (frontiersin.org)
  • Different approaches to obtain haploid germ cells from cryopreserved SGS are described in the literature: transplantation of purified SGS cell suspensions, testicular tissue autograft and in vitro maturation (MIV) to the haploid stage (6). (uclouvain.be)
  • This will be used to support testicular cells previously isolated and selected from TTI. (uclouvain.be)
  • Preserved seminiferous tubule integrity with spermatogonial survival and induction of Sertoli and Leydig cell maturation after long-term organotypic culture of prepubertal human testicular tissue. (uclouvain.be)
  • RESEARCH OBJECTIVES Background On September 9 and 10, 2002, NIDDK sponsored a meeting entitled, "Genetic Modifiers of Mendelian Diseases" highlighting progress toward the identification of modifier genes in diseases of interest to NIDDK. (nih.gov)
  • Modifier genes may contribute to the variable age of onset seen in this disease. (nih.gov)
  • After transplantation, recognition of host cells as foreign entities by donor T cells induces graft-vs.-host disease (GVHD). (frontiersin.org)
  • Activation, proliferation and trafficking of donor T cells to target organs and tissues are critical steps in the pathogenesis of GVHD. (frontiersin.org)
  • HCT is an immunotherapy procedure during which a healthy donor provides hematopoietic cells including stem and progenitor cells to a diseased host. (frontiersin.org)
  • Transplantation of donor-derived cells is an attempt to re-establish hematopoietic and immunological activities in the host. (frontiersin.org)
  • Based on HLA phenotyping and source of donor hematopoietic cells, allo-HCT can be further divided into match related, match unrelated and haploidentical HCT. (frontiersin.org)
  • Risk factors for Buruli ulcer disease ( Mycobacterium ulcerans infection): results from a case-control study in Ghana. (mdedge.com)
  • The aim of this study was to investigate the influence of sickle cell disease, socioeconomic characteristics, and oral conditions on oral health-related quality of life of children and teens. (scielo.br)
  • a range of other diseases or conditions. (kidspot.com.au)
  • Children with underlying conditions remain at increased risk for invasive pneumococcal diseases (IPD). (aappublications.org)
  • An interdisciplinary research team from the University of Illinois' Institute for Genomic Biology (IGB) report in the February issue of the journal Experimental Biology and Medicine the engineering of novel peptide sequences that are sensitive to redox conditions inside cells. (innovations-report.com)
  • It will see if this treatment can reduce disease complications, such as shortness of breath, pain crisis, pneumonia, and increase survival. (unt.edu)
  • Most infections are asymptomatic or only cause mild disease, so in the majority of cases no treatment is needed. (clinicaladvisor.com)
  • Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. (bookdepository.com)
  • These experiments establish the versatility and clinical relevance of our microvasculature-on-a-chip model as a biophysical assay of hematologic pathophysiology as well as a drug discovery platform. (jci.org)