Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.
A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.
The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group.
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.
The reduction or regulation of the population of noxious, destructive, or dangerous plants, insects, or other animals. This includes control of plants that serve as habitats or food sources for animal pests.
Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
The development and establishment of environmental conditions favorable to the health of the public.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
Process by which unwanted microbial, plant or animal materials or organisms accumulate on man-made surfaces.

Water traffic accidents, drowning and alcohol in Finland, 1969-1995. (1/316)

OBJECTIVE: To examine age- and sex-specific mortality rates and trends in water traffic accidents (WTA), and their association with alcohol, in Finland. MATERIALS AND METHODS: National mortality and population data from Finland, 1969-1995, are used to analyse rates and trends. The mortality rates are calculated on the basis of population, per 100000 inhabitants in each age group (<1, 1-4, 5-14, 15-24, 25-44, 45-64, > or = 65), and analysed by sex and age. The Poisson regression model and chi2 test for trend (EGRET and StatXact softwares) are used to analyse time trends. RESULTS: From 1969 through 1995 there were 3473 (2.7/100000/year; M:F= 20.4:1) WTA-related deaths among Finns of all ages. In 94.7% of the cases the cause of death was drowning. Alcohol intoxication was a contributing cause of death in 63.0% of the fatalities. During the study period the overall WTA mortality rates declined significantly (-4% per year; P < 0.001). This decline was observed in all age groups except > or = 65 year olds. The overall mortality rates in WTA associated with alcohol intoxication (1987-1995) also declined significantly (-6%; P = 0.01). CONCLUSIONS: In Finland, mortality rates in WTA are exceptionally high. Despite a marked decline in most age groups, the high mortality in WTA nevertheless remains a preventable cause of death. Preventive countermeasures targeted specifically to adult males, to the reduction of alcohol consumption in aquatic settings and to the use of personal safety devices should receive priority.  (+info)

Legionnaires' disease on a cruise ship linked to the water supply system: clinical and public health implications. (2/316)

The occurrence of legionnaires' disease has been described previously in passengers of cruise ships, but determination of the source has been rare. A 67-year-old, male cigarette smoker with heart disease contracted legionnaires' disease during a cruise in September 1995 and died 9 days after disembarking. Legionella pneumophila serogroup 1 was isolated from the patient's sputum and the ship's water supply. Samples from the air-conditioning system were negative. L. pneumophila serogroup 1 isolates from the water supply matched the patient's isolate, by both monoclonal antibody subtyping and genomic fingerprinting. None of 116 crew members had significant antibody titers to L. pneumophila serogroup 1. One clinically suspected case of legionnaires' disease and one confirmed case were subsequently diagnosed among passengers cruising on the same ship in November 1995 and October 1996, respectively. This is the first documented evidence of the involvement of a water supply system in the transmission of legionella infection on ships. These cases were identified because of the presence of a unique international system of surveillance and collaboration between public health authorities.  (+info)

A historical cohort mortality study of workers exposed to asbestos in a refitting shipyard. (3/316)

To investigate the risks of developing asbestos-related diseases we conducted a historical cohort mortality study on 249 ship repair workers (90 laggers and 159 boiler repairers) in a single U.S. Navy shipyard in Japan. We successfully identified the vital status of 87 (96.7%) laggers and 150 (94.3%) boiler repairers, and, of these, 49 (56.3%) and 65 (43.3%) died, respectively, during the follow-up period from 1947 till the end of 1996. Our in-person interviews with some of the subjects clarified that asbestos exposure was considered to be substantially high in the 1950-60s, decreased thereafter gradually but remained till 1979 in the shipyard. The laggers, who had handled asbestos materials directly, showed a significantly elevated SMR of 2.75 (95% C.I.: 1.08-6.48) for lung cancer. The risk developing the disease was greater in the laggers after a 20-year latency (SMR = 3.42). Pancreatic cancer yielded a greater SMR than unity (7.78, 90% C.I.: 2.07-25.19) in a longer working years group. Four laggers died from asbestosis. The boiler repairers, who had many chances for secondary exposure to asbestos and a few for direct exposure, showed no elevation of the SMR of lung cancer overall, but there was a borderline statistically significant SMR of 2.41 (90% C.I.: 1.05-5.45) in a longer working years group. One boiler repairer died from mesothelioma and four from asbestosis.  (+info)

Evaluation of exposure to ethylene glycol monoethyl ether acetates and their possible haematological effects on shipyard painters. (4/316)

OBJECTIVES: To evaluate exposure to mixed solvents containing ethylene glycol monoethyl ether acetate (EGEEA) in shipyard painters, to determine if EGEEA is toxic to the bone marrow. METHODS: An industrial hygiene survey was performed to identify exposure to EGEEA of two groups of shipyard painters, a low exposure group (n = 30) and a high exposure group (n = 27). Urinary ethoxyacetic acid and methyl hippuric acid as well as haemoglobin, packed cell volume, red cell indices, total and differential white blood cell counts (WBCs), and platelet count for the shipyard painters and the control subjects were measured. RESULTS: The mean (range) exposure concentration (ppm) to EGEEA in the high and low exposure groups were 3.03 (not detectable to 18.27), 1.76 (not detectable to 8.12), respectively. The concentrations of methyl hippuric acid and ethoxyacetic acid in the high exposure group were significantly higher than those in the control group. The mean WBCs in the high exposure group were significantly lower than in the control group, and a significant proportion, six (11%) of the 57 painters, were leucopenic; none of the controls were affected. CONCLUSION: The high rate of possible haematological effects among shipyard painters and a hygienic evaluation of their working environment in the present study suggests that EGEEA might be toxic to bone marrow.  (+info)

Health effects of solvent exposure among dockyard painters: mortality and neuropsychological symptoms. (5/316)

OBJECTIVES: To study mortality and prevalence of neuropsychological symptoms among a cohort of painters known to have been heavily exposed to organic solvents. METHODS: A mortality study of 1292 male painters who had worked in a dockyard in Scotland for > or = 1 year between 1950 and 1992 comprised a nested cross sectional study of 953 surviving painters from the cohort and 953 male non-painters randomly selected from the local population and a case-control study of those with high symptom scores. Mortality, symptoms, and risks associated with painting, adjusting for age, education, smoking, alcohol, and personality were measured. RESULTS: The proportional mortality ratio for all cancers was not increased significantly (110 (95% confidence interval (95% CI) 84 to 143), except for a possible excess of deaths from ischaemic heart disease (132, 105 to 164). Standardised mortality ratios were not significantly increased. Among the 260 surviving painters and 539 community controls who responded to the questionnaire there was a significant excess of symptoms among painters; adjusted relative risk (RR) increased significantly with increasing symptom score. These RRs suggested an exposure-response relation; for a high score (12-22) for all symptoms RR was 2.27 (1.20 to 4.30) for 1-4 years of exposure, 2.42 (1.18 to 4.95) for 5-9 years, 2.89 (1.42 to 5.88) for 10-14 years, and 3.41 (1.82 to 6.36) for 15-41 years, compared with controls. In multivariate analyses, painting exposure, and aging were associated with high symptom scores and there was again an increased risk relative to time worked as a painter. CONCLUSION: This study supports the hypothesis that heavy and prolonged exposure to paint solvents leads to neuropsychological ill health.  (+info)

Neuropsychological symptoms in Chinese male and female painters: an epidemiological study in dockyard workers. (6/316)

OBJECTIVES: To study the prevalences of neuropsychological symptoms in male and female dockyard painters in China and to compare them with those in British dockyard painters. METHODS: All 116 painters were identified, active and retired, who had been employed in two Chinese dockyards for at least 1 year together with a matched random sample of 263 dockyard non-painters. Neuropsychological and personality questionnaires that we had used previously in a study of United Kingdom dockyard painters were used, translated into Chinese. Neuropsychological symptoms in painters and controls were compared, adjusting for age, educational level, smoking, alcohol intake, and personality. RESULTS: The response rate was 94% for painters and 97% for controls. Highly significant excesses of symptoms were found in painters, suggestive of neuropsychological dysfunction. Both male and female painters showed higher relative risks than were found in similar tradespeople in the United Kingdom. The relative risk increased with increasing score of both neurological and psychological symptoms. Relative risk of having a high symptom score, compared with controls and adjusted for confounders, was 6.61 (95% confidence interval (95% CI) 2.36 to 18.50) for 2-15 years exposure, 14.88 (5.74 to 38.56) for 16-22 years and 9.42 (3.97 to 22.36) for > or = 22 years. CONCLUSION: These results indicate that neuropsychological symptoms are associated with heavy exposure to painting work in China, and that the phenomenon is likely to be found worldwide wherever there is such exposure to solvent based paints. The high response rate in this study answers a possible criticism of the earlier United Kingdom study.  (+info)

Osler usque ad mare: the SS William Osler. (7/316)

William Osler's connections with the sea included a strong family history of seafaring, his own transatlantic crossings (of which there were at least 32) and the occasional use of nautical imagery in his inspirational writings. An unusual Oslerian connection with the sea emerged after his death in the form of a World War II Liberty ship. Through the SS William Osler and its sister ships, Osler was symbolically reunited with colleagues associated with the early days of the Johns Hopkins Hospital. The William Osler circumnavigated the globe in 1943 without engaging the enemy. She was then converted into an army hospital ship and renamed the USHS Wisteria.  (+info)

Preventing commercial fishing deaths in Alaska. (8/316)

OBJECTIVES: To evaluate the effectiveness of the United States Commercial Fishing Industry Vessel Safety Act of 1988 in reducing the high occupational death rate (200/100,000/year in 1991-2) among Alaska's commercial fishermen. METHODS: Comprehensive surveillance of deaths in commercial fishing was established by our office during 1991 and 1992 for Alaska. Demographic data and data on risk factors and incidents were compiled and analysed for trend. RESULTS: During 1991-8, there was a significant (p < 0.001) decrease in deaths in Alaska related to commercial fishing. Although drownings from fishermen falling overboard and events related to crab fishing vessels (often conducted far offshore and in winter) have continued to occur, marked progress (significant downward trend, p < 0.001) has been made in saving the lives of people involved in vessels capsizing and sinking. CONCLUSIONS: Specific measures tailored to prevent drowning associated with vessels capsizing and sinking in Alaska's commercial fishing industry have been successful. However, these events continue to occur, and place fishermen and rescue personnel at substantial risk. Additional strategies must be identified to reduce the frequency of vessels capsizing and sinking, to enable parallel improvements in the mortality among crab fishermen, and to prevent fishermen falling overboard and drownings associated with them.  (+info)

I'm sorry for any confusion, but "ships" is not a medical term. It is a common noun referring to large vehicles used for transportation on water. If you have any medical questions or terms you would like defined, I would be happy to help!

Phosphoric monoester hydrolases are a class of enzymes that catalyze the hydrolysis of phosphoric monoesters into alcohol and phosphate. This class of enzymes includes several specific enzymes, such as phosphatases and nucleotidases, which play important roles in various biological processes, including metabolism, signal transduction, and regulation of cellular processes.

Phosphoric monoester hydrolases are classified under the EC number 3.1.3 by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB). The enzymes in this class share a common mechanism of action, which involves the nucleophilic attack on the phosphorus atom of the substrate by a serine or cysteine residue in the active site of the enzyme. This results in the formation of a covalent intermediate, which is then hydrolyzed to release the products.

Phosphoric monoester hydrolases are important therapeutic targets for the development of drugs that can modulate their activity. For example, inhibitors of phosphoric monoester hydrolases have been developed as potential treatments for various diseases, including cancer, neurodegenerative disorders, and infectious diseases.

Naval medicine, also known as marine medicine or maritime medicine, is a branch of medicine that deals with the prevention and treatment of diseases and injuries that occur in naval or maritime environments. This can include conditions related to sea travel, such as motion sickness, decompression sickness, and infectious diseases spread through contaminated water or food. It also covers occupational health concerns for naval personnel, including hearing loss from exposure to loud noises, respiratory problems from inhaling fumes, and musculoskeletal injuries from heavy lifting. Additionally, naval medicine may address the unique mental health challenges faced by naval personnel, such as those related to isolation, stress, and combat.

SRC homology domains, often abbreviated as SH domains, are conserved protein modules that were first identified in the SRC family of non-receptor tyrosine kinases. These domains are involved in various intracellular signaling processes and mediate protein-protein interactions. There are several types of SH domains, including:

1. SH2 domain: This domain is approximately 100 amino acids long and binds to specific phosphotyrosine-containing motifs in other proteins, thereby mediating signal transduction.
2. SH3 domain: This domain is about 60 amino acids long and recognizes proline-rich sequences in target proteins, playing a role in protein-protein interactions and intracellular signaling.
3. SH1 domain: Also known as the tyrosine kinase catalytic domain, this region contains the active site responsible for transferring a phosphate group from ATP to specific tyrosine residues on target proteins.
4. SH4 domain: This domain is present in some SRC family members and serves as a membrane-targeting module by interacting with lipids or transmembrane proteins.

These SH domains allow SRC kinases and other proteins containing them to participate in complex signaling networks that regulate various cellular processes, such as proliferation, differentiation, survival, and migration.

Phosphatidylinositol phosphates (PIPs) are a family of lipid molecules that play crucial roles as secondary messengers in intracellular signaling pathways. They are formed by the phosphorylation of the hydroxyl group on the inositol ring of phosphatidylinositol (PI), a fundamental component of cell membranes.

There are seven main types of PIPs, classified based on the number and position of phosphate groups attached to the inositol ring:

1. Phosphatidylinositol 4-monophosphate (PI4P) - one phosphate group at the 4th position
2. Phosphatidylinositol 5-monophosphate (PI5P) - one phosphate group at the 5th position
3. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) - two phosphate groups at the 3rd and 4th positions
4. Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) - two phosphate groups at the 3rd and 5th positions
5. Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] - two phosphate groups at the 4th and 5th positions
6. Phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] - three phosphate groups at the 3rd, 4th, and 5th positions
7. Phosphatidylinositol 3-phosphate (PI3P) - one phosphate group at the 3rd position

These PIPs are involved in various cellular processes such as membrane trafficking, cytoskeleton organization, cell survival, and metabolism. Dysregulation of PIP metabolism has been implicated in several diseases, including cancer, diabetes, and neurological disorders.

IgG receptors, also known as Fcγ receptors (Fc gamma receptors), are specialized protein molecules found on the surface of various immune cells, such as neutrophils, monocytes, macrophages, and some lymphocytes. These receptors recognize and bind to the Fc region of IgG antibodies, one of the five classes of immunoglobulins in the human body.

IgG receptors play a crucial role in immune responses by mediating different effector functions, including:

1. Antibody-dependent cellular cytotoxicity (ADCC): IgG receptors on natural killer (NK) cells and other immune cells bind to IgG antibodies coated on the surface of virus-infected or cancer cells, leading to their destruction.
2. Phagocytosis: When IgG antibodies tag pathogens or foreign particles, phagocytes like neutrophils and macrophages recognize and bind to these immune complexes via IgG receptors, facilitating the engulfment and removal of the targeted particles.
3. Antigen presentation: IgG receptors on antigen-presenting cells (APCs) can internalize immune complexes, process the antigens, and present them to T cells, thereby initiating adaptive immune responses.
4. Inflammatory response regulation: IgG receptors can modulate inflammation by activating or inhibiting downstream signaling pathways in immune cells, depending on the specific type of Fcγ receptor and its activation state.

There are several types of IgG receptors (FcγRI, FcγRII, FcγRIII, and FcγRIV) with varying affinities for different subclasses of IgG antibodies (IgG1, IgG2, IgG3, and IgG4). The distinct functions and expression patterns of these receptors contribute to the complexity and fine-tuning of immune responses in the human body.

SHC (Src homology 2 domain containing) signaling adaptor proteins are a family of intracellular signaling molecules that play a crucial role in the transduction of signals from various cell surface receptors, including receptor tyrosine kinases (RTKs). These proteins contain several conserved domains, including Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which enable them to bind to specific phosphorylated tyrosine residues on activated receptors or other signaling molecules.

Once bound to the activated receptor, SHC proteins recruit and interact with various downstream signaling proteins, such as growth factor receptor-bound protein 2 (Grb2) and son of sevenless (SOS), thereby initiating intracellular signaling cascades that ultimately regulate diverse cellular processes, including proliferation, differentiation, survival, and migration. There are three main isoforms of SHC proteins in humans: p66Shc, p52Shc, and p46Shc, which differ in their structural organization and functional properties.

Abnormal regulation of SHC signaling adaptor proteins has been implicated in various pathological conditions, including cancer, diabetes, and neurodegenerative diseases. Therefore, understanding the molecular mechanisms underlying SHC-mediated signaling pathways may provide valuable insights into the development of novel therapeutic strategies for these disorders.

I'm sorry for any confusion, but "pest control" is not a term typically used in medical definitions. Pest control refers to the regulation or management of species considered to be pests, which can include insects, rodents, and other organisms that can cause damage to crops, transmit diseases, or otherwise negatively impact human activities.

In a medical context, you might be looking for information on "pesticide exposure" or "insect-borne diseases." Pesticide exposure refers to the contact with pesticides, which are substances used to control pests. These exposures can occur through inhalation, ingestion, or skin contact and may lead to a variety of health effects depending on the type and amount of pesticide involved. Insect-borne diseases are illnesses transmitted to humans through the bite of infected insects, such as mosquitoes, ticks, or fleas. Examples include malaria, Lyme disease, and Zika virus infection.

Cholestanes are a type of steroid compound that are derived from cholesterol. They are characterized by a fully saturated steroid nucleus, which means that all of the double bonds in the cholesterol molecule have been reduced to single bonds through a process called hydrogenation.

Cholestanes are important intermediates in the biosynthesis of other steroids, such as bile acids and steroid hormones. They can also be found in some natural sources, including certain plants and fungi.

It's worth noting that cholestanes themselves do not have any specific medical significance, but they are important for understanding the biochemistry of steroids and their role in human health and disease.

1. Receptors: In the context of physiology and medicine, receptors are specialized proteins found on the surface of cells or inside cells that detect and respond to specific molecules, known as ligands. These interactions can trigger a variety of responses within the cell, such as starting a signaling cascade or changing the cell's metabolism. Receptors play crucial roles in various biological processes, including communication between cells, regulation of immune responses, and perception of senses.

2. Antigen: An antigen is any substance (usually a protein) that can be recognized by the adaptive immune system, specifically by B-cells and T-cells. Antigens can be derived from various sources, such as microorganisms (like bacteria, viruses, or fungi), pollen, dust mites, or even components of our own cells (for instance, in autoimmune diseases). An antigen's ability to stimulate an immune response is determined by its molecular structure and whether it can be recognized by the receptors on immune cells.

3. B-Cell: B-cells are a type of white blood cell that plays a critical role in the adaptive immune system, particularly in humoral immunity. They originate from hematopoietic stem cells in the bone marrow and are responsible for producing antibodies, which are proteins that recognize and bind to specific antigens. Each B-cell has receptors on its surface called B-cell receptors (BCRs) that can recognize a unique antigen. When a B-cell encounters its specific antigen, it becomes activated, undergoes proliferation, and differentiates into plasma cells that secrete large amounts of antibodies to neutralize or eliminate the antigen.

Sanitation is the provision of facilities and services for the safe disposal of human feces and urine, and the cleaning of homes, workplaces, streets, and other spaces where people live and work. This includes the collection, transport, treatment, and disposal or reuse of human waste, as well as the maintenance of hygienic conditions in these areas to prevent the spread of diseases.

The World Health Organization (WHO) defines sanitation as "the use of toilets or latrines that safely dispose of human waste, as well as the safe management of human waste at the household, community, and national levels." Sanitation is an essential component of public health and is critical for preventing the spread of infectious diseases such as cholera, typhoid, hepatitis A, and polio.

Poor sanitation can have serious consequences for individuals and communities, including increased risk of disease and death, decreased productivity, reduced economic growth, and negative impacts on social and mental well-being. Providing access to safe sanitation is a key target of the United Nations Sustainable Development Goals (SDGs), with a goal to ensure that everyone has access to adequate and equitable sanitation by 2030.

Phosphorylation is the process of adding a phosphate group (a molecule consisting of one phosphorus atom and four oxygen atoms) to a protein or other organic molecule, which is usually done by enzymes called kinases. This post-translational modification can change the function, localization, or activity of the target molecule, playing a crucial role in various cellular processes such as signal transduction, metabolism, and regulation of gene expression. Phosphorylation is reversible, and the removal of the phosphate group is facilitated by enzymes called phosphatases.

Phosphatidylinositol 3-Kinases (PI3Ks) are a family of enzymes that play a crucial role in intracellular signal transduction. They phosphorylate the 3-hydroxyl group of the inositol ring in phosphatidylinositol and its derivatives, which results in the production of second messengers that regulate various cellular processes such as cell growth, proliferation, differentiation, motility, and survival.

PI3Ks are divided into three classes based on their structure and substrate specificity. Class I PI3Ks are further subdivided into two categories: class IA and class IB. Class IA PI3Ks are heterodimers consisting of a catalytic subunit (p110α, p110β, or p110δ) and a regulatory subunit (p85α, p85β, p55γ, or p50γ). They are primarily activated by receptor tyrosine kinases and G protein-coupled receptors. Class IB PI3Ks consist of a catalytic subunit (p110γ) and a regulatory subunit (p101 or p84/87). They are mainly activated by G protein-coupled receptors.

Dysregulation of PI3K signaling has been implicated in various human diseases, including cancer, diabetes, and autoimmune disorders. Therefore, PI3Ks have emerged as important targets for drug development in these areas.

Signal transduction is the process by which a cell converts an extracellular signal, such as a hormone or neurotransmitter, into an intracellular response. This involves a series of molecular events that transmit the signal from the cell surface to the interior of the cell, ultimately resulting in changes in gene expression, protein activity, or metabolism.

The process typically begins with the binding of the extracellular signal to a receptor located on the cell membrane. This binding event activates the receptor, which then triggers a cascade of intracellular signaling molecules, such as second messengers, protein kinases, and ion channels. These molecules amplify and propagate the signal, ultimately leading to the activation or inhibition of specific cellular responses.

Signal transduction pathways are highly regulated and can be modulated by various factors, including other signaling molecules, post-translational modifications, and feedback mechanisms. Dysregulation of these pathways has been implicated in a variety of diseases, including cancer, diabetes, and neurological disorders.

Tyrosine is an non-essential amino acid, which means that it can be synthesized by the human body from another amino acid called phenylalanine. Its name is derived from the Greek word "tyros," which means cheese, as it was first isolated from casein, a protein found in cheese.

Tyrosine plays a crucial role in the production of several important substances in the body, including neurotransmitters such as dopamine, norepinephrine, and epinephrine, which are involved in various physiological processes, including mood regulation, stress response, and cognitive functions. It also serves as a precursor to melanin, the pigment responsible for skin, hair, and eye color.

In addition, tyrosine is involved in the structure of proteins and is essential for normal growth and development. Some individuals may require tyrosine supplementation if they have a genetic disorder that affects tyrosine metabolism or if they are phenylketonurics (PKU), who cannot metabolize phenylalanine, which can lead to elevated tyrosine levels in the blood. However, it is important to consult with a healthcare professional before starting any supplementation regimen.

Biofouling is the accumulation of microorganisms, algae, plants, and animals on wet surfaces, such as the hulls of ships, pier pilings, and buoys. This growth can have negative impacts on the performance and efficiency of equipment and infrastructure, leading to increased maintenance costs and potential environmental damage. In the medical field, biofouling can also refer to the undesirable accumulation of microorganisms or biomolecules on medical devices, which can lead to infection or device failure.

... or biggest ships may refer to: List of longest ships List of largest ships by gross tonnage This disambiguation ... page lists articles associated with the title Largest ships. If an internal link led you here, you may wish to change the link ...
During its operation, it also operated a number of ships. "Great Central Railway". Simplon Postcards. Retrieved 28 March 2011. ... Lists of ships of the United Kingdom, London and North Eastern Railway). ...
... website Official Sinking Ships myspace Sinking Ships interview at REDEFINE Magazine, September 2006 Sinking Ships ... Sinking Ships Records, 2007) Split [w/ My Love & As We Let Go] (Alliance Trax, 2008) Sinking Ships (Sinking Ships Records, 2008 ... Sinking Ships was an American hardcore punk band from Seattle, Washington, formed in 2004. In 2005, the band released their ... In the spring and summer of 2008, Sinking Ships played Rainfest (May 8) and Sound And Fury (July 8) This was to be their final ...
ISBN 978-0-521-82992-2. Viking Ship Museum. "The five Viking ships - The Skuldelev Ships". Vikinges Kibs Museet. Archived from ... of the original ship has been preserved. Skuldelev 1 has been replicated as the Viking ship Ottar by the Roskilde Viking Ship ... Ships preserved in museums, Viking ships, Archaeological sites in Denmark, Danish Culture Canon, 11th-century ships). ... Roskilde Viking Ship Museum has replicated Skuldelev 3 as the Viking ship replica Roar Ege. Skuldelev 5 is a small warship of ...
"Danielson - Ships". AllMusic. Schreiber, Ryan (May 10, 2006). "Danielson Famile: Ships". Pitchfork. Retrieved April 9, 2019. ... "Ship the Majestic Suffix" - 2:54 "Cast It at the Setting Sail" - 3:30 "Bloodbook on the Halfshell" - 4:50 "Did I Step on Your ... Ships is the seventh full-length album by New Jersey indie rock band Danielson. The album was a massive collaboration among ... "Review: Danielson - Ships". Tiny Mix Tapes. Retrieved April 9, 2019. v t e v t e (Articles with short description, Short ...
For Handling Ships, Halas and Batchelor used stop motion animation of three-dimensional ship models, along with schematic ... instead serving as a precise guide to manoeuvring and navigating ships, along with aspects of general ship handling and control ... Handling Ships is a 1945 British stop motion animated film made by Halas and Batchelor. The 70-minute film was created at the ... "Handling Ships - main". British Film Institute site. Archived from the original on 13 February 2009. Retrieved 20 December 2008 ...
The Nemi ships were two ships, of different sizes, built under the reign of the Roman emperor Caligula in the 1st century AD on ... From the size of the ships it was long held that they were pleasure barges, though, as the lake was sacred, no ship could sail ... Before the recovery of the Nemi ships, scholars often ridiculed the idea that the Romans were capable of building a ship as big ... Together it leaves little doubt as to when the ships were built or for whom. Suetonius describes two ships built for Caligula ...
Later in 1922, other intellectuals were transported by train to Riga in Latvia or by ship from Odessa to Istanbul. Vladimir ... The main load was handled by two German ships, the Oberbürgermeister Haken and the Preussen, which transported more than 200 ... The philosophers' ships or philosopher's steamers (Russian: Философский пароход) were steamships that transported intellectuals ...
The ship's 350-member crew included Mercy Ships founders Don and Deyon Stephens, who lived on board the ship with their four ... Dake, Shawn, Mercy Ships: First 25 Years, Mercy Ships. "Sierra Leone: Nation Honors Mercy Ships Founder". Concord Times. ... The Mercy Ships 2013 field service in Pointe Noire marked the first visit by a Mercy Ship to the Republic of Congo. Mercy Ships ... The Mercy Ships 2012 field service in Conakry marked the third visit by a Mercy Ship to Guinea, which was also visited by the ...
"Wooden Ships". Wooden Ships (liner notes). 1991. "Paul Kantner's Wooden Ships - Blows Against The Empire: Hi Jack / Have You ... "The wooden ships/were just a hippie dream" which is later altered to "The wooden ships are a hippie dream/capsized in excess/if ... "Wooden Ships" was written at the height of the Vietnam War, a time of great tension between the United States and the Soviet ... "Wooden Ships" is a song written and composed by David Crosby, Paul Kantner, and Stephen Stills, of which versions were ...
The album title references the song "I Saw Three Ships", which states, "I saw three ships come sailing in, on Christmas day in ... "Jon Anderson: Three Ships: AllMusic Review". AllMusic. Retrieved 19 November 2016. " - Jon Anderson - 3 Ships" ( ... fans would do well to let Three Ships sail by." Side One "Save All Your Love" 1:25 "Easier Said Than Done" 4:12 "3 Ships" 3:44 ... "Three Ships - Jon Anderson , AllMusic". Retrieved 20 August 2011. Fielder, Hugh (1985) "Jon Anderson '3 Ships'", ...
In the age of sail, arming or victualling a war ship, or war vessel had the meaning of equipping the ships with all the ... that list the variety of items needed to arm a ship. 1283. Ramon Muntaner often talks about arming galleys and other ships. E ... In the Mediterranean there are many important and famous places where ships were built, armed and victualled, especially those ...
... is a studio album by American jazz pianist Andrew Hill featuring performances recorded in 1969 for the Blue Note ... Passing Ships-Releases on Discogs". Jurek, T. Allmusic Review accessed September 30, 2010 Cook, Richard; Morton, Brian (2008). ... "Passing Ships" - 7:08 "Plantation Bag" - 8:32 "Noon Tide" - 9:49 "The Brown Queen" - 6:22 "Cascade" - 6:27 "Yesterday's ...
"Merchant Ships discography - RYM/Sonemic". "Merchant Ships". Sputnikmusic. Retrieved 26 November 2015. "Merchant Ships - I.W.T. ... Merchant Ships was an American post-hardcore band from South Bend, Indiana. Merchant Ships was formed in 2008 by singer Jack ... "Merchant Ships - For Cameron". Sputnikmusic. Retrieved 26 November 2015. Shotwell, James. "Merchant Ships call it quits, give ... In May 2009, Merchant Ships parted ways for the first time. In the summer of the same year, Senff and Stutsman formed Midwest ...
"45cat - Ian Hunter - Ships / Wild East - Chrysalis - UK - CHS 2346". 45cat. Retrieved 24 January 2022. "Ships by Ian Hunter". ... "Ships (original)" on YouTube Barry Manilow "Ships (cover)" on YouTube v t e (Articles with hAudio microformats, Articles with ... "Ships" was later recorded by singer Barry Manilow for his sixth studio album, One Voice. It was the first of three singles ... Manilow's rendition of "Ships" peaked at number 9 on the Billboard Hot 100 and number 4 on the Adult Contemporary chart. His ...
... and Shipping. London: Leicester University Press, ISBN 978-0-7185-0117-4 S. McGrail: "Medieval boats, ships, ... Columbus's ship, the Santa María was a famous example of a carrack. The ships commanded by Vasco da Gama as the São Gabriel, ... Medieval ships were the vessels used in Europe during the Middle Ages. Like ships from antiquity, they were moved by sails, oar ... These late hulks could be as large as contemporary great ships. Jesus of Lübeck of 1544 was a ship of 700 long tons (780 short ...
According to the invisible ships (or ships not seen) myth, when European explorers' ships approached either North America, ... The large sailing ships did not resemble the smaller canoe-like ships that were more familiar. Philosopher J. R. Hustwit wrote ... The movie goes on to add a shaman to the narrative, who began to see ripples in the water and eventually could see the ship. ... This passage is also preceded by his observation that ten people had gone up to a hill to see the ship. Contrary to the myth, ...
The steam-powered ships, a mere four boats are enough to make us lose sleep at night. Kurofune ("The Black Ships") is also the ... The Black Ships (in Japanese: 黒船, romanized: kurofune, Edo period term) was the name given to Western vessels arriving in Japan ... The ships were Mississippi, Plymouth, Saratoga, and Susquehanna of the Expedition for the opening of Japan, under the command ... The surprise and fear inspired by the first visit of the Black Ships are described in this famous kyōka (a humorous poem in 31- ...
V.Ships is a ship management company, part of V.Group Holdings Limited which is registered in Monaco but headquartered in ... In February 2022, it was announced that all ships owned by Crystal Cruises and Dream Cruises would now be managed by V.Ships as ... V Group Limited was formed in 1984 and supplies ship management and related marine services to the global shipping industry. V. ... V.Group are one of the largest ship management companies in the world. In November 2016, two large ship management companies ...
... the lengthy refueling or coaling required by steam ships brought considerable additional risk to the ship and hardship to the ... His ship, the Borodino-class battleship Knyaz Suvorov, found all neutral ports closed, leaving it the choice of either coaling ... "Coaling Ship" . New International Encyclopedia. 1905. "The life of a stoker in the Royal Navy". Excellent description of the ... These problems were sufficiently serious for the Royal Navy to build HMS Queen Elizabeth as an oil-fired ship despite an ...
Ships of CP Ships, Defunct shipping companies of Canada, Defunct shipping companies of the United Kingdom, Military history of ... On October 19, 2005, CP Ships and TUI AG jointly announced that 89.1% of CP Ships shareholders had accepted Ship Acquisition ... Canadian Pacific provided ships to carry troops in both World Wars. CP lost 18 ships in the war. In World War I, some ships ... The ship began to list too far, and additional life rafts were not able to be launched. The ship rolled to its side ten minutes ...
... is an accessory for the Advanced Dungeons & Dragons fantasy role-playing game. Lost Ships is a Spelljammer ... SJR1 Lost Ships was written by Ed Greenwood, with a cover by Brom, and was published by TSR in 1990 as a 96-page book. Schick, ... supplement which describes a region of space where derelict ships and strange creatures congregate. ...
Both ships were used for ship burials here around AD 700-750 in the Nordic Iron Age and contained the remains of 41 warriors ... The Salme ships are two clinker-built ships of Scandinavian origin discovered in 2008 and 2010 near the village of Salme on the ... The second ship was discovered in 2010. There is some indirect evidence pointing to the possibility that at least one more ship ... the irregular rows of strong rivets found on the bottom of the ship also indicate that the ship used sails. This makes it the ...
Among these ships was the Rouse Simmons, a Christmas tree ship which sank in Lake Michigan in 1912. Christmas tree shipping ... Ships laden with Christmas gifts for distribution were also referred to as "Christmas ships" in the early twentieth century, ... Every night, Christmas Ships ferry the merry. Seattle Times, December 7, 2011. Christmas ships in the night. The Columbian, ... Google Books CHRISTMAS SHIPS SAIL; The Oceanic and St. Paul Due in England Dec. 24.. New York Times, December 18, 1902. Doris ...
... Select Three Ships 5 Year Old Premium Select Three Ships 10 Year Old Single Malt Three Ships Bourbon Cask Finish ... "Three Ships 5 Year Old Select Whisky". "Three Ships 10 Years Old". "Three Ships Whisky ... In 2015, Three Ships 10 Year Old Single Malt won Best African Single Malt. Official website "Three Ships 10 Year Old". Master ... The Three Ships range includes blended and single malt whiskies. Three Ships is owned by Distell, a multinational brewing and ...
... or ship husbandry is all aspects of maintenance, cleaning, and general upkeep of the hull, rigging, and ... "Underwater Ship Husbandry". SUPSALV. Washington, DC: Naval Sea Systems Command. Retrieved 17 March 2017. "Underwater Ship ... and reduces the time a ship is required to stay in dry-dock. Underwater ship husbandry includes the following operations, ... Underwater ships husbandry can be financially advantageous when it eliminates the need for dry-dock repairs or extends the ...
"Stellar Ships" or "Star Ships" (Russian name "Zvezdnye Korabli", Russian: Звёздные корабли) is a short story by the Soviet ...
... with cruise ships, an aircraft carrier, fishing boats, dredgers and various types of cargo ships, naval and specialist ships ... "Discovery Channel Highlights Africa Mercy in Mighty Ships Program". Mercy Ships. Archived from the original on ... Mighty Cruise Ships is a spin-off series focusing on cruise ships which began to air in late 2014. A typical episode follows ... A second season of Mighty Cruise Ships aired on the Discovery Channel and repeated on the quest channel in the UK. Ships ...
... long Kvalsund ship Ladby ship Myklebust Ship Roskilde 6 [da]: found during the expansion of the Viking Ship Museum and the ... The average speed of Viking ships varied from ship to ship but lay in the range of 5 to 10 knots (9 to 19 km/h), and the ... Birlinn Galley Salme ships Ships in Norse mythology "Eldar Heide (2014). The early Viking Ship types (Sjøfartshistorisk årbok ... The most notable of these few ships include: Gokstad ship: overall length - approximately 23.3 m (76 ft) Oseberg ship: overall ...
If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship ... This article includes a list of ships with the same or similar names. ...
Cruise Ship Medical Capabilities. Medical facilities on cruise ships can vary widely depending on ship size, itinerary, cruise ... Cruise ship medical centers deal with a wide variety of illnesses and injuries; ≈10% of conditions reported to cruise ship ... Although cruise ships do not have public health authority, to reduce the risk of introducing communicable diseases, some ships ... Cruise ship COVID-19 outbreaks can tax onboard medical and public health resources. Ship-to-shore medical evacuations to ...
During its operation, it also operated a number of ships. "Great Central Railway". Simplon Postcards. Retrieved 28 March 2011. ... Lists of ships of the United Kingdom, London and North Eastern Railway). ...
"By requiring cruise ships to connect to shore power, this law will limit harmful emissions and mitigate pollution, noise, and ... Cruise ships docked at the Citys terminals often run dirty diesel engines while idling, generating harmful emissions that ... Shore power allows ships to shut down engines and plug into electrical grid power while stationary. ... New York City Council Votes to Require Cruise Ships to Connect to Shore Power When Docked at Terminals. March 7, 2024 ...
... streamlines printing of shipping labels, automates tracking of the shipments. ... Purchase shipping label in a single click. *Bulk purchase and download of consolidated shipping labels PDF file for multiple ... Estimates ChitChats shipping rates in the cart, lets customers to choose shipping method, allows to track shipments as well as ... Flexible shipping rate adjustment rules. Configure how quoted shipping rates should be adjusted, which is useful if your store ...
L.L.Bean offers free regular shipping with $75 purchase. ... Free Ship-to-Store Delivery Most available items can be shipped ... Please note: Free Standard Shipping is offered on orders of $75 or more shipped to a single U.S. address. If you are shipping ... Free Standard Shipping is valid on orders of $75 or more (after promotions and discounts are applied) shipped to a single US ... Shipping and handling charges plus a delivery date will be listed for all available shipping methods. See the chart below for ...
Posted in Updates , Tagged bicycle, brown, buying, eBay, selling, Sheldon, sheldonbrown, shipping, value , Comments Off on ... Tag Archives: shipping Selling Bicycles and Components. Posted on March 11, 2020 by John ... There is a new section about shipping. This article holds all the basic information you need on where to post an advertisement ...
Mercy Ships (903) 939-7000 P.O. Box 1930 Garden Valley, TX 75771 ... By submitting, I consent to receive content from Mercy Ships in ...
... (SOR/2010-203). Full Document: *HTMLFull Document: Certain Ships Remission Order, 2010 ( ... XMLFull Document: Certain Ships Remission Order, 2010 [4 KB] , *PDFFull Document: Certain Ships Remission Order, 2010 [154 KB] ...
Expand navigation for Ships named for Individual Sailors Ships named for Individual Sailors * Ships named for Individual ... Expand navigation for Specifications for Ship and Motor Boat Bells Specifications for Ship and Motor Boat Bells * General ... Ship Name. Person Named For. Command at Pearl Harbor. Award. Post-. humous. ... Ships Sunk and Damaged in Action during the Korean Conflict * A Short Account of the Several General Duties of Officers, of ...
Find frequently asked shipping with Xlibris questions and answers. ... General shipping information. All shipping transit times quoted herein are to be counted in business days, not calendar days. ... Shipping Options. Orders sent with USPS Regular Mail are not trackable or insured. Expedited shipping is available for an ... International Shipping. International shipping is any order not destined for the United States, Canada, Great Britain, or ...
C has no chance of success unless aviation and shipping pay for the pollution they cause ... Aircraft and ships must not be exempt from emissions cuts. The deal to limit global warming to 1.5 °C has no chance of success ... Ships and aircraft are getting a free ride.. Following on from Rio, the Kyoto protocol of 1997 - the first serious ... A deal that proposes to limit warming to well below 2 °C but fails to mention ships and aircraft is farcical. They both ...
Its called the Oasis of the Seas, and its the largest cruise ship ever built - five times the size of the Titanic, with a ... Its part cruise ship, part theme park. For many cruisers, its the ship, not the Caribbean ports it visits, that will be the ... Its called the Oasis of the Seas, and its the largest cruise ship ever built - five times the size of the Titanic, with a ... Gigantic Cruise Ship Buoys Companys Hopes Were headed into the years biggest travel week, and theres not much bigger than ...
Israel says it intercepted a container ship carrying weapons in the Mediterranean and indicated they included missiles destined ... Israeli Navy Intercepts Arms Ship Off Coast JERUSALEM (Reuters) -- Israel says it intercepted a container ship carrying weapons ... In February, Ukraines military said it had destroyed the Tsezar Kunikov, one of the largest Russian landing ships, also off ... In addition, he noted that Huthi rebels in Yemen backed by Iran have targeted international shipping in the Red Sea and there ...
... reduced sea ice cover is increasingly allowing ships to sail across the Arctic Ocean without support from icebreaker ships. ... And ships are still encountering plenty of ice as they sail closer to the North Pole and in waters that are not well charted. ... The impacts on shipping cargo by boat could be significant. Water levels can drop such that rivers can become too shallow to ... Over the seven-year span, the mean center of shipping activity moved 300 kilometers north and east-closer to the North Pole. ...
The ACCC investigates complaints from parties adversely affected by a shipping conference agreement. We can also start our own ... The ACCC can investigate complaints from parties adversely affected by a shipping conference agreement. ...
... ship Marjata from the port of Kirkenes, which is eight kilometers from the Russian border, to Harstad The new home port for ... The Norwegian ELINT ships have been prime sources of details on how the Russian jammers and other EW equipment works when ... The Russians still have an opportunity to use their EW systems on Marjata but only when the ship is in the Barents Sea seeking ... ELINT operations, like those of the two Norwegian ELINT ships (and those of other NATO nations as well as ELINT aircraft), are ...
Shipping Policy. If not indicated otherwise, we ship via GLS. Please see below the price list for shipping costs and delivery ...
1264 Shipping & Freight /index.php/site_content/item/1264-nvocc-shipping-freight ... Shipping and Freight Resource fully supports this initiative of the IMB which sets out the standards for the issuance of NVOCC ... Safeguard against shipping and freight fraudThis supports banks in relation to their compliance procedures to prevent fraud, ... At the most basic level, an NVOCC enters into volume-based ocean freight arrangements with the various shipping lines operating ...
I feel like I have one foot on the ship and one foot here, she says. I never really belonged anywhere except the ship, and I ... Her mother, Susan, is an executive assistant on the ship, while Parker (whose first name means mercy) attended the ships ... Growing up on a hospital ship, I really saw the hands and feet of Jesus. To witness the blind see, the lame walk, and the ... Parker, 19, is the first person to have been raised entirely on a Mercy Ships vessel, and one of three to have completed high ...
The Port of San Diego has asked cargo and cruise ships to reduce their speed when traveling in and out of San Diego Bay. KPBS ... Ships Reduce Speeds For Cleaner Air. The Port of San Diego has asked cargo and cruise ships to reduce their speed when ... The Port of San Diego has asked cargo and cruise ships to reduce their speed when traveling in and out of San Diego Bay. KPBS ... John Pasha says a review determined the ship could maintain its delivery schedule even at slower speeds. ...
Download thousands of free icons of shipping and delivery in SVG, PSD, PNG, EPS format or as ICON FONT ...
French maritime giant plans on extending its business alliance with Asian shipping giants Cosco, Evergreen and OOCL until 2032. ... French, Asian shipping giants extend alliance. French maritime giant plans on extending its business alliance with Asian ... French maritime shipping giant CMA CGM said Tuesday it was extending the sectors biggest operational alliance with Chinese ... CMA CGM, the worlds third biggest shipping company, said in a statement that the Ocean Alliance, in place since 2017, enables ...
XMLFull Document: Ship Station (Radio) Technical Regulations, 1999 [1 KB] , *PDFFull Document: Ship Station (Radio) Technical ... Ship Station (Radio) Technical Regulations, 1999 (SOR/2000-265). Full Document: *HTMLFull Document: Ship Station (Radio) ... Ship Station (Radio) Technical Regulations, 1999 [Repealed, SOR/2020-216, s. 428] ...
Tall Ship Grace OMalley Arrives in Cork Harbour Tall ship Grace OMalley arriving in Cork Harbour this evening for a weekend ... The new ship is a replica of a famous 19th-century wooden ship The Lady Ellen. A successful Swedish industrialist who had seen ... Displaying items by tag: Tall Ships. 5th February 2024 Dublin Lord Mayor Hosts 2024 Tall Ships Voyages Awards Ceremony ... The ship is a civilian square-rigger offering tall ship voyages, regardless of previous experience, from her home port of ...
... and shipping info.  Available sizes 7-inch Softcover: Minimum 20 pages, maximum 140 pages ... Shipping options. Important: Priority shipping doesnt support delivery to PO boxes. You can use economy shipping instead. ... Details on shipping. *If you live in the U.S. or Canada, you can only ship within the country where you bought the photo book. ... Check photo book product & shipping info. Choose a country from the list below to find product and shipping info. ...
The photogenic Tall Ships sailed into Boston this weekend, where they will stay until Thursday. Here are the best Instagram ... Fifty-six ships took part in a Parade of Sail Saturday morning, and now each of them are available to board (for free!) on ... Its a rare opportunity to see so many Tall Ships in one place up close, and for those with the eye for it, its a great chance ... The Tall Ships sailed into Boston this weekend, bringing crowds of spectators to ogle their huge, elegant majesty. ...
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Otis Marine products serve all marine segments, including cruise ships, ferries, commercial ships, offshore platforms and naval ... Elevators and escalators on cruise ships are subject to heavy traffic. On average, passenger lifts record 2,000 runs per day. ... In heavy rolling seas, the elevators on ships are programed to detect excessive motions and park automatically on pre- ... Every detail on a ship contributes to that impression. Otis builds in aesthetics during project development and the elevators ...
Learn about our fast and reliable shipping options for your footwear and apparel orders. Experience hassle-free delivery with ... Shipping. Shipping Guidelines:. All orders ship and deliver during business days Monday - Friday (not Including ... Sample Shipping Timing for Express Shipping. Orders placed on Monday will ship out on Tuesday and will be delivered between ... Do you offer Expedited Shipping?. We have expedited shipping options available depending on shipping address. ...
  • 10% of conditions reported to cruise ship medical centers are an emergency or require urgent care. (
  • Before travel, to help limit the introduction and spread of communicable diseases on cruise ships, prospective cruise ship travelers and their clinicians should consult the Centers for Disease Control and Prevention (CDC) Travelers' Health website for updates on outbreaks and destination-specific travel health notices. (
  • When is a ship sanitation certificate required? (
  • Ships in international traffic must have a valid ship sanitation certificate confirming that there are no infectious agents or other hazardous substances on board. (
  • The master of the ship must be able to present a ship sanitation certificate to the Swedish Coast Guard or Swedish Customs upon arrival at the first Swedish port. (
  • The CDC Vessel Sanitation Program (VSP) helps the cruise ship industry prevent and control GI illnesses on cruise ships. (
  • Mercy Ships is a 501 (c)(3) organization. (
  • By submitting, I consent to receive content from Mercy Ships in accordance with their Privacy Policy . (
  • For 27 years, Parker's father, Gary, has been an oral and maxillofacial surgeon for Mercy Ships, the maritime ministry that spun off from Youth With a Mission in 2003. (
  • Parker, 19, is the first person to have been raised entirely on a Mercy Ships vessel, and one of three to have completed high school on the ship. (
  • CDC and federal regulations require the master of a ship sailing from a non-US port destined to a US port to immediately report any death or certain illnesses among the ship's passengers or crew, including travelers who have disembarked or were removed from the ship due to illness or death. (
  • Are you located in Canada and looking to offer competitive trackable shipping rates to your Canadian, USA and International customers? (
  • The Port of New York, which encompasses the cruise terminals in Red Hook and in Midtown Manhattan, is the third largest cruise market in the U.S. and one of the busiest cruise and shipping ports in the nation. (
  • For many cruisers, it's the ship, not the Caribbean ports it visits, that will be the destination. (
  • In fact, only a handful of ports in the Caribbean are large enough to handle the Oasis and its sister ship, Allure of the Seas, set for delivery next year. (
  • CMA CGM, the world's third biggest shipping company, said in a statement that the Ocean Alliance, in place since 2017, enables its members to provide fast transit times and a broad range of ports. (
  • Prévention des accidents à bord des navires en mer et dans les ports. (
  • Trainees recognised for their exceptional contributions to Sail Training Ireland's Tall Ships voyages in 2023 were honoured at the Annual Awards Ceremony at the Mansion House in Dublin. (
  • The 534 trainees who sailed on the tall ships last year were eligible for the awards, with the winners selected for their outstanding achievements. (
  • Dublin City Council and Dublin Port Company have been jointly supporting the charity since the Tall Ships Race Festival in 2012. (
  • The Tall Ships sailed into Boston this weekend, bringing crowds of spectators to ogle their huge, elegant majesty. (
  • It's a rare opportunity to see so many Tall Ships in one place up close, and for those with the eye for it, it's a great chance to get some premium Instagram pics. (
  • The Parade of Tall Ships! (
  • Because travelers at sea might need to rely on a ship's medical capabilities for an extended period, potential cruise passengers with preexisting medical needs should prepare accordingly by calling the cruise line's customer service center to learn what type and level of health care services are (and are not) available on specific ships. (
  • For information on how to report travelers who become ill with suspected communicable diseases after they return home from a cruise, see Sec. 8, Ch. 8, Airplanes & Cruise Ships: Illness & Death Reporting & Public Health Interventions . (
  • Although no agency officially regulates medical practice aboard cruise ships, the American College of Emergency Physicians (ACEP) published consensus-based guidelines for cruise ship medical facilities in 1995, and updated the guidelines in 2013. (
  • Another innovation, according to Royal Caribbean Vice President Ken Muskat, is a design concept that creates seven different "neighborhoods" aboard the ship. (
  • The Port of San Diego has asked cargo and cruise ships to reduce their speed when traveling in and out of San Diego Bay. (
  • Results of search for 'su:{Ships. (
  • Its aim is to let trainees practice the skills they are likely to use in a live ship inspection and to determine how they will apply the Ship Sanitation Inspection knowledge and skills within their own work environment. (
  • Rather, home is a 500-foot-long hospital ship that sails along the west coast of Africa, treating those with little or no medical care. (
  • The eLearning course aims at introducing the key competencies, with a focus on knowledge and skills, required to perform Ship Sanitation Inspections. (
  • The Public Health Agency of Sweden has appointed 53 municipalities that are entitled to issue ship sanitation certificates following inspections. (
  • Williams was one of the travel agents on board for a complimentary outing last week before the ship sets sail with paying passengers next month. (
  • He said: "Sail Training Ireland promotes education and youth development through adventure, shared experiences, and challenge by introducing young people to life on a Tall Ship as a platform for personal development. (
  • French maritime giant plans on extending its business alliance with Asian shipping giants Cosco, Evergreen and OOCL until 2032. (
  • French maritime shipping giant CMA CGM said Tuesday it was extending the sector's biggest operational alliance with Chinese group Cosco Shipping, Taiwan's Evergreen and Hong Kong-based OOCL until 2032. (
  • This page does not include information related to COVID-19 reporting for cruise ships. (
  • For information on COVID-19 reporting for cruise ships, see Guidance for Cruise Ships on the Mitigation and Management of COVID-19 . (
  • For oversized items that ship by freight, you'll see an estimate of the delivery time on the product page, as well as a pop-up window with complete information about freight delivery. (
  • Please see below the price list for shipping costs and delivery times. (
  • John Pasha says a review determined the ship could maintain its delivery schedule even at slower speeds. (
  • Priority shipping doesn't support delivery to PO boxes. (
  • The most frequently reported cruise ship outbreaks involve GI infections (e.g., norovirus), respiratory infections (e.g., coronavirus disease 2019 [COVID-19], influenza), and other vaccine-preventable diseases (VPDs), such as varicella. (
  • The 126 meter (400 foot) long Marjata entered service in 2016 and was the fourth Norwegian ELINT ship with that name. (
  • Learn more about CDC's new recommendations concerning specimen storage and ship. (
  • At the most basic level, an NVOCC enters into volume-based ocean freight arrangements with the various shipping lines operating across the various trade lanes. (
  • Safeguard against shipping and freight fraudThis supports banks in relation to their compliance procedures to prevent fraud, money laundering and sanctions breaches, especially since banks are not obligated or have no resources to verify if the goods have been shipped on board. (
  • The Public Health Agency of Sweden's regulations and general guidelines contain information about the municipalities with the power to issue ship sanitation certificates, the certificate's formulation, when a ship must present such a certificate, and which authority must receive the certificate. (
  • By altering EDC's cruise terminal operating contracts, the bill intends to reduce emissions from ships at berth while addressing community impacts through traffic mitigation plans. (
  • Although cruise ships do not have public health authority, to reduce the risk of introducing communicable diseases, some ships conduct medical screening during embarkation to identify ill passengers, prevent them from boarding, or require isolation if permission to board is given. (
  • When GRASP services are requested, staff build a 3D image of the ship and plot outbreak data, including cabins of ill passengers and crew members. (
  • Orders sent with standard shipping are not eligible for replacements if lost in transit or if damaged. (
  • The municipality can then conduct an inspection to ensure that the ship is free of substances that pose a threat to human health. (
  • JERUSALEM (Reuters) -- Israel says it intercepted a container ship carrying weapons in the Mediterranean and indicated they included missiles destined for Lebanon's Hizballah guerrilla group. (
  • Military sources said naval commandos stormed the ship in international waters and the Defense Ministry said the vessel was boarded near Cyprus. (
  • Medical facilities on cruise ships can vary widely depending on ship size, itinerary, cruise duration, and passenger demographics. (
  • Example of typical shipping papers used for ground transport of Category A substances. (
  • Guide de soins médicaux d' urgence à donner en cas d' accidents dus à des marchandises dangereuses (GSMU : supplément du Guide médical international de bord (substances chimiques. (
  • The Learning Programme is designed for ship inspectors who are in charge of inspection of ships and issuance of Ship Sanitation Certificates under the IHR (2005). (
  • Ship sanitation certificates are used to prevent, detect and manage international threats to human health. (
  • Municipalities must use the official form that can be found on page 129-130 (annex 1) in WHO:s handbook for the inspection of ships and issuance of ship sanitation certificates. (
  • Municipalities can also use the evidence report form found on page 141-142 (annex 8) in Handbook for the inspection of ships and issuance of ship sanitation certificates. (
  • WooCommerce Chit Chats Shipping plugin is a feature rich WordPress / WooCommerce extension that helps you to automate Chit Chats shipping by packing items into boxes and displaying precise real-time shipping rates in the cart and checkout pages. (
  • Based on the products in the cart, box dimensions they can fit into and address of the customer, it fetches real-time shipping rates from Chit Chats service and displays them in the cart, and checkout pages. (
  • Shipping time isn't guaranteed. (
  • The Oasis is the first ship to offer two-story, loft-style cabins priced as high as $34,000 per week. (
  • Estimates ChitChats shipping rates in the cart, lets customers to choose shipping method, allows to track shipments as well as create shipping labels right from the WP Admin order page. (
  • If you are shipping to multiple locations, each address must have an order total of $75 or more to receive Free Shipping. (
  • If you would like to ship an order to a store, please call us to place an order at 1-800-441-5713. (
  • To ship to multiple addresses, you'll need to place a separate order for each address. (
  • You'll receive an e-mail on the day your order is shipped. (
  • When selecting the expedited option, you understand your order will ship after the book(s) has/have been printed. (
  • International shipping is any order not destined for the United States, Canada, Great Britain, or Australia. (
  • Please double check all shipping/billing addresses, quantities, and shipping options before submitting your order. (
  • Then go back to your shopping bag and click the "Shipping to" dropdown menu, selecting the nickname for the address you set up in your account. (
  • Accident prevention on board ship at sea and in port. (
  • This plugin offers integration with third-party services (ChitChats) that may charge fees for various services including, but not limited to, live shipping rates, address validation, and printing labels. (
  • If you live in the U.S. or Canada, you can only ship within the country where you bought the photo book. (
  • With our air and water at stake, I remain committed to putting community health needs over the corporate greed of the cruise ship industry and last mile polluters. (
  • ChitChats is the unique shipping service provider that offers possibility to ship your e-commerce and personal packages via USA as if you were physically there. (
  • All shipping timelines and service levels are based on the date your books leave the printing warehouse. (
  • Book copies purchased during free shipping special promotions are delivered via Unites States Postal Service Priority Mail. (
  • The previous Marjata, which entered service in 1992, remained in service but renamed the Eger and the two ELINT ships often operate together. (
  • Each year, millions of people travel on cruise ships to enjoy a variety of unique experiences. (
  • The largest weapons-smuggling ship intercepted by the Israeli Navy was the 'Karin A,' a vessel boarded in 2002 that carried tons of weapons that Israel said Iran had sent to Palestinians in the Gaza Strip. (
  • Support for shore power capacity would greatly lower emissions, reduce the carbon footprint, and create an advantage to the ship operator by reducing the overall costs in the field. (
  • Norway is moving its ELINT (electronic intelligence) ship Marjata from the port of Kirkenes, which is eight kilometers from the Russian border, to Harstad. (
  • All shipping transit times quoted herein are to be counted in business days, not calendar days. (
  • VSP archives records for ships that are no longer sailing in the United States. (
  • It means that you will be able to offer shipping methods such as USPS First Class, USPS Priority, UPS Mail Innovation and other shipping methods with tracking for the rates similar to your USA competitors, so your customers won't even noticed any differences of ordering from you vs other USA located companies. (
  • As with all of our shipping methods, tracking information will be forwarded to the e-mail address provided during registration. (
  • Cruise ship travel presents a unique combination of health concerns. (
  • Enhance the abilities of competent authorities to protect public health by achieving greater compliance from ship operators with the SSC provisions under the IHR (2005). (
  • Information on international shipping can be found here . (
  • Chit Chats Shipping plugin provides easy access to the tracking information , automatically emails customer their tracking number and then follow up emails with the progress of the shipment. (
  • In most cases, this variation will decrease shipping times as the orders have less distance to travel to reach you. (
  • Backordered items, as well as some items that require special handling (such as furniture, boats and gift cards), cannot be shipped to a store. (
  • Code of safety for special purpose ships. (
  • Your books can be shipped from a variety of printing warehouses. (
  • Free Standard Shipping is valid on orders of $75 or more (after promotions and discounts are applied) shipped to a single US address. (
  • Free Standard Shipping is offered on orders of $75 or more shipped to a single U.S. address. (
  • It is the customer's responsibility to keep Xlibris UK updated with the most current and accurate shipping address prior to the placement of orders. (
  • Unless stated otherwise, shipping charges must be shouldered by the buying party for regular book orders. (
  • It's called the Oasis of the Seas, and it's the largest cruise ship ever built - five times the size of the Titanic, with a price tag of $1.5 billion. (