Sex determining region y protein. Medical search

A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.

An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.

The primary testis-determining gene in mammalians, located on the Y CHROMOSOME. It codes for a high mobility group box transcription factor (TRANSCRIPTION FACTORS) which initiates the development of the TESTES from the embryonic GONADS.

A subclass of SOX transcription factors that are expressed in neuronal tissue where they may play a role in the regulation of CELL DIFFERENTIATION. Members of this subclass are generally considered to be transcriptional activators.

Validation of the SEX of an individual by inspection of the GONADS and/or by genetic tests.

A family of low-molecular weight, non-histone proteins found in chromatin.

A phenolphthalein that is used as a diagnostic aid in hepatic function determination.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.

Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.

The totality of characteristics of reproductive structure, functions, PHENOTYPE, and GENOTYPE, differentiating the MALE from the FEMALE organism.

The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.

Linear SRY transcript in equine testis. (1/289)

Employing a combination of reverse transcription-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) techniques, the complete coding sequence of cDNA for the equine SRY gene was determined. We also attempted to make clear whether the equine SRY gene transcript is expressed in the adult testis, and whether the type of transcript is expressed as linear or circular RNA. As a result, in total a 1420 bp cDNA sequence was determined. Accomplishment of 3' RACE infers that equine SRY gene was expressed as a linear RNA transcript in testicular tissue just after puberty, in contrast to the situation in mice. (+info)

From head to toes: the multiple facets of Sox proteins. (2/289)

Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found throughout the animal kingdom. They are involved in the regulation of such diverse developmental processes as germ layer formation, organ development and cell type specifi-cation. Hence, deletion or mutation of Sox proteins often results in developmental defects and congenital disease in humans. Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other. (+info)

Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. (3/289)

We recently reported detection of a transient increase in circulating donor leukocytes (WBCs) in immunocompetent recipients 3 to 5 days posttransfusion (tx) (Blood 85:1207, 1995). We have now characterized survival kinetics of specific donor WBC subsets in additional tx populations. Eight female elective surgery patients (pts) were sampled pre-tx and on days 1, 3, 5, 7, and 14 post-tx. Ten female trauma pts transfused with a total of 4 to 18 U of relatively fresh red blood cells were sampled up to 1.5 years post-tx. WBC subsets from frozen whole blood were isolated using CD4, CD8 (T cell), CD15 (myeloid), and CD19 (B cell) antibody-coated magnetic beads. Donor WBCs were counted by quantitative polymerase chain reaction (PCR) of male-specific sex determining region (SRY) sequences. PCR HLA typing and mixed leukocyte reaction (MLR) between recipient and donor WBCs were performed on two of the trauma tx recipients who had long-term chimerism of donor cells post-tx. In 6 of 8 female surgery pts, circulating CD4(+) male donor cells peaked at day 3 or 5 (0.01 to 1 cell/microL), followed by clearance by day 14. In 7 of 10 female trauma pts, we observed multilineage persistence of male donor WBCs (CD4, CD8, CD15, CD19) for 6 months to 1.5 years post-tx at concentrations of 10 to 100 cells/microL. In 2 trauma recipients studied, MLR showed no, or very low, response to WBC of the single donor implicated as the source of microchimerism by HLA typing. Establishment of long-term multilineage chimerism in trauma recipients is probably caused by engraftment of donor stem cells and mutual tolerance between recipient and donor leukocytes. A better understanding of factors determining clearance versus chimerism of transfused leukocytes is critical to prevention of alloimmunization and transfusion-induced graft-versus-host disease, and, potentially, to induction of tolerance for transplantation. (+info)

Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding. (4/289)

NHP6A is a chromatin-associated protein from Saccharomyces cerevisiae belonging to the HMG1/2 family of non-specific DNA binding proteins. NHP6A has only one HMG DNA binding domain and forms relatively stable complexes with DNA. We have determined the solution structure of NHP6A and constructed an NMR-based model structure of the DNA complex. The free NHP6A folds into an L-shaped three alpha-helix structure, and contains an unstructured 17 amino acid basic tail N-terminal to the HMG box. Intermolecular NOEs assigned between NHP6A and a 15 bp 13C,15N-labeled DNA duplex containing the SRY recognition sequence have positioned the NHP6A HMG domain onto the minor groove of the DNA at a site that is shifted by 1 bp and in reverse orientation from that found in the SRY-DNA complex. In the model structure of the NHP6A-DNA complex, the N-terminal basic tail is wrapped around the major groove in a manner mimicking the C-terminal tail of LEF1. The DNA in the complex is severely distorted and contains two adjacent kinks where side chains of methionine and phenylalanine that are important for bending are inserted. The NHP6A-DNA model structure provides insight into how this class of architectural DNA binding proteins may select preferential binding sites. (+info)

The human SRY protein is present in fetal and adult Sertoli cells and germ cells. (5/289)

Sex determination in mammals is controlled by the Y chromosome located SRY gene. Despite recent advances towards understanding the mechanisms that regulate sex determination in mammals, the expression profile of the SRY protein in human tissues is unknown. To localize the SRY protein and determine its cellular distribution, we prepared monoclonal antibodies (mAb) against the recombinant SRY protein. One antibody, LSRY1.1, recognizes a SRY-specific epitope and was used to localize the protein in different cells and tissues. The mAb recognizes a protein of 27 kDa in total lysates of HeLa SRYB3 cells. Immunocytochemical staining showed a nuclear localization of the protein. Immunohistochemical studies performed on gonadal tissue of a fetus, a one month-old boy and an adult man, demonstrated the presence of SRY protein in the nucleus of Sertoli and germ cells. In addition two 46,XX SRY(+) males had the SRY protein in their gonadal tissues. All other samples were negative, including all female tissue studied and the testis of a 46,XX SRY(-) male. The presence of SRY protein in fetal and adult gonadal tissues including germ cells suggests that SRY may have other male-specific functions in addition to sex determinism. (+info)

Isolation and characterization of a mouse SRY-related cDNA, mSox7. (6/289)

SOX is a family of SRY-related genes, which encode transcriptional factors involved in development. In this study, we newly isolated and sequenced mouse cDNA clones for mSox7. The mSox7 gene encodes 380 amino acids containing an SRY-type HMG box. Genomic Southern analysis suggested that the mSox7 gene was a single-copy gene. Tissue specific expression of mSox7 was investigated by Northern analysis. The expression was restricted to the ovary and heart, and the size of the transcripts was estimated to be 3.6 knt. Electrophoretic mobility shift assay indicated that recombinant mSox7 polypeptide was capable of binding to a nucleotide sequence, AACAAT. Immunohistochemical study revealed that mSox7 protein was localized in oocytes in the mouse ovary. (+info)

Bone marrow as a potential source of hepatic oval cells. (7/289)

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability. (+info)

Mammalian Y chromosome evolution and the male-specific functions of Y chromosome-borne genes. (8/289)

All mammals have an XY chromosomal sex determining system, in which a small Y chromosome triggers male development, and contains genes required for spermatogenesis. The X and Y chromosomes were originally homologous, but diverged during evolution as the Y chromosome was degraded progressively. Comparisons among the sex chromosomes of different mammal groups indicate that the X and Y chromosomes received additions of material from other chromosomes. Genes on the Y chromosome originated from the ancient X-Y pair, or from these additions, or were copies of genes on one of the autosomes. Only genes with important male-specific functions, such as sex determination and spermatogenesis, are selected for and retained on the differential region of the Y chromosome. The mammalian sex determining gene, SRY, controls the testis determination pathway, which includes at least one related gene. Several candidate spermatogenesis genes have been identified, but so far the only one that is conserved on the Y chromosome of all therian mammals is RBM (RNA-binding motif gene, Y chromosome). (+info)

The Sex-Determining Region Y (SRY) protein is a transcription factor that plays a critical role in male sex determination. It is encoded by the SRY gene, which is located on the Y chromosome in humans and many other mammal species. The primary function of the SRY protein is to initiate the development of the testes during embryonic development.

In the absence of a functional SRY protein, the gonads will develop into ovaries. With a functional SRY protein, the gonads will develop into testes, which then produce androgens, including testosterone, that are necessary for the development of male secondary sexual characteristics. Mutations in the SRY gene can lead to sex reversal, where an individual with a Y chromosome develops as a female due to non-functional or absent SRY protein.

High Mobility Group AT-Hook 1 (HMGA1) is a non-histone chromosomal protein that belongs to the HMGA family. The HMGA proteins are characterized by their ability to bind to AT-rich regions in the minor groove of DNA and modulate the chromatin structure, thereby regulating gene transcription.

The HMGA1 protein exists in two isoforms, HMGA1a and HMGA1b, which differ in their amino acid sequences due to alternative splicing of the HMGA1 pre-mRNA. The HMGA1a isoform has 108 amino acids, while HMGA1b has 109 amino acids.

HMGA1 proteins play crucial roles in various cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of HMGA1 expression has been implicated in several human diseases, such as cancer, where it functions as a transcriptional regulator of genes involved in tumorigenesis.

"SRY" (Sex Determining Region Y) is not a gene itself but a specific region on the Y chromosome that contains the genetic information necessary to initiate male sex determination. The SRY region encodes a protein called the testis-determining factor (TDF), which plays a crucial role in the development of the male phenotype by triggering the differentiation of the gonadal ridge into testes.

The SRY gene is typically found only on the Y chromosome and is considered one of the primary genetic factors that distinguish males from females in many mammalian species, including humans. Mutations or abnormalities in the SRY region can lead to sex chromosome-related disorders of sexual development (DSDs), such as Swyer syndrome or XY female disorder of sex development, where individuals with a 46,XY karyotype develop female phenotypes due to the absence or dysfunction of the SRY protein.

SOXB1 transcription factors are a subgroup of the SOX (SRY-related HMG box) family of transcription factors, which are characterized by a conserved high mobility group (HMG) box DNA-binding domain. The SOXB1 subfamily includes SOX1, SOX2, and SOX3, which play crucial roles during embryonic development and in the maintenance of stem cells. They regulate gene expression by binding to specific DNA sequences and interacting with other transcription factors and cofactors. SOXB1 proteins have been implicated in various biological processes, such as neurogenesis, eye development, and sex determination. Dysregulation of SOXB1 transcription factors has been associated with several human diseases, including cancer.

Sex determination analysis is a medical or biological examination used to establish the genetic or phenotypic sex of an individual. This can be done through various methods, including:

1. Genetic testing: Examination of an individual's DNA to identify the presence of specific sex chromosomes (XX for females and XY for males). This is typically performed through a blood or tissue sample.
2. Chromosomal analysis: Microscopic examination of an individual's chromosomes to determine their number and structure. In humans, females typically have 46 chromosomes, including two X chromosomes (46,XX), while males typically have 46 chromosomes, including one X and one Y chromosome (46,XY).
3. Phenotypic analysis: Observation of an individual's physical characteristics, such as the presence or absence of certain sex organs or secondary sexual characteristics, to determine their phenotypic sex.

Sex determination analysis is used in various medical and research contexts, including prenatal testing, diagnosis of disorders of sex development (DSDs), forensic investigations, and population studies. It's important to note that while sex determination analysis can provide information about an individual's genetic or phenotypic sex, it does not necessarily reflect their gender identity, which is a personal sense of being male, female, or something else.

High mobility group proteins (HMG proteins) are a family of nuclear proteins that are characterized by their ability to bind to DNA and influence its structure and function. They are named "high mobility" because of their rapid movement in gel electrophoresis. HMG proteins are involved in various nuclear processes, including chromatin remodeling, transcription regulation, and DNA repair.

There are three main classes of HMG proteins: HMGA, HMGB, and HMGN. Each class has distinct structural features and functions. For example, HMGA proteins have a unique "AT-hook" domain that allows them to bind to the minor groove of AT-rich DNA sequences, while HMGB proteins have two "HMG-box" domains that enable them to bend and unwind DNA.

HMG proteins play important roles in many physiological and pathological processes, such as embryonic development, inflammation, and cancer. Dysregulation of HMG protein function has been implicated in various diseases, including neurodegenerative disorders, diabetes, and cancer. Therefore, understanding the structure, function, and regulation of HMG proteins is crucial for developing new therapeutic strategies for these diseases.

Sulfobromophthalein (BSP or bromsulphthalein) is not typically defined in a medical dictionary as it is a chemical compound. However, I can provide you with some information about its use in a medical context:

Sulfobromophthalein is a chemical compound primarily used for liver function tests. It is a dye that is injected into the patient's bloodstream, and then its clearance rate from the blood is measured to evaluate liver function. A healthy liver should quickly remove the dye from the blood and excrete it through the bile ducts into the digestive system. If the liver is not functioning properly, the clearance of sulfobromophthalein will be slower, leading to higher levels of the dye remaining in the bloodstream over time.

The test using sulfobromophthalein has largely been replaced by more modern and specific liver function tests; however, it was once widely used for assessing overall liver health and diagnosing conditions such as hepatitis, cirrhosis, and liver damage due to various causes.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

"Sex factors" is a term used in medicine and epidemiology to refer to the differences in disease incidence, prevalence, or response to treatment that are observed between males and females. These differences can be attributed to biological differences such as genetics, hormones, and anatomy, as well as social and cultural factors related to gender.

For example, some conditions such as autoimmune diseases, depression, and osteoporosis are more common in women, while others such as cardiovascular disease and certain types of cancer are more prevalent in men. Additionally, sex differences have been observed in the effectiveness and side effects of various medications and treatments.

It is important to consider sex factors in medical research and clinical practice to ensure that patients receive appropriate and effective care.

"Sex characteristics" refer to the anatomical, chromosomal, and genetic features that define males and females. These include both primary sex characteristics (such as reproductive organs like ovaries or testes) and secondary sex characteristics (such as breasts or facial hair) that typically develop during puberty. Sex characteristics are primarily determined by the presence of either X or Y chromosomes, with XX individuals usually developing as females and XY individuals usually developing as males, although variations and exceptions to this rule do occur.

In medical terms, "sex" refers to the biological characteristics that define males and females. These characteristics include chromosomes, hormone levels, reproductive/sexual anatomy, and secondary sexual traits. Generally, people are categorized as male or female based on their anatomical and genetic features, but there are also intersex individuals who may have physical or genetic features that do not fit typical binary notions of male or female bodies. It is important to note that while sex is a biological concept, gender is a social construct that refers to the roles, behaviors, activities, and expectations that a society considers appropriate for men and women.

The Y chromosome is one of the two sex-determining chromosomes in humans and many other animals, along with the X chromosome. The Y chromosome contains the genetic information that helps to determine an individual's sex as male. It is significantly smaller than the X chromosome and contains fewer genes.

The Y chromosome is present in males, who inherit it from their father. Females, on the other hand, have two X chromosomes, one inherited from each parent. The Y chromosome includes a gene called SRY (sex-determining region Y), which initiates the development of male sexual characteristics during embryonic development.

It is worth noting that the Y chromosome has a relatively high rate of genetic mutation and degeneration compared to other chromosomes, leading to concerns about its long-term viability in human evolution. However, current evidence suggests that the Y chromosome has been stable for at least the past 25 million years.

... (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene- ... "Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex- ... Sex-Determining+Region+Y+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) PDBe-KB provides an ... "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif". Nature. 346 ( ...

https://en.wikipedia.org/wiki/Sex-determining_region_Y_protein

SRY (sex determining region Y)-box 30 is a protein that in humans is encoded by the SOX30 gene. This gene encodes a member of ... The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may ... provided by RefSeq, Jul 2013]. "Entrez Gene: SRY (sex determining region Y)-box 30". Retrieved 2014-05-29. Koopman, P; Schepers ... Human proteins, All stub articles, Human chromosome 5 gene stubs). ...

https://en.wikipedia.org/wiki/SOX30

"Entrez Gene: SOX15 SRY (sex determining region Y)-box 15". Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co- ... The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. SOX genes ... Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene. This gene encodes a member of the SOX (SRY-related HMG ... 1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11". ...

https://en.wikipedia.org/wiki/SOX15

"Entrez Gene: SOX14 SRY (sex determining region Y)-box 14". Wilson M, Koopman P (August 2002). "Matching SOX: partner proteins ... The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in ... Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene. This intronless gene encodes a member of ...

https://en.wikipedia.org/wiki/SOX14

SOX gene family Sex-Determining Region Y Protein SOX1, SOX2, etc. TCF/LEF family (T cell factor/lymphoid enhancer factor family ... HMG-box proteins are found in a variety of eukaryotic organisms. They were originally isolated from mammalian cells, and named ... Antibodies to HMG proteins are found in patients with autoimmune diseases. The SRY gene on the Y Chromosome, responsible for ... The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain: HMGA - contains an AT- ...

https://en.wikipedia.org/wiki/High-mobility_group

The sex-determining region of the human Y chromosome encodes a finger protein Genealogies of mouse inbred strains Mutations in ... Fisher, Elizabeth M. C. (1987). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): ... Her early work looked at the male sex determining factor and then considered the genes responsible for Turner syndrome. Fisher ... She has investigated how the RNA-binding protein mutant FUS behaves in mouse models. Fisher serves as a Council Member at the ...

https://en.wikipedia.org/wiki/Elizabeth_Fisher_(neuroscientist)

"The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091-104. doi:10.1016/0092-8674( ... Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. This gene encodes ... Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and ... In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes ...

https://en.wikipedia.org/wiki/ZFY

"The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091-1104. doi:10.1016/0092-8674( ... "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif". Nature. 346 ( ... Despite a belief among geneticists that the Y chromosome contained few genes other than the sex-determining gene, Page ... Nature published his findings together with a paper from the British group that identified the sex-determining gene, which they ...

https://en.wikipedia.org/wiki/David_C._Page

"Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets". Diabetes. 49 (4): 555 ... "Entrez Gene: SOX13 SRY (sex determining region Y)-box 13". Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, ... The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also ... SOX13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...

https://en.wikipedia.org/wiki/SOX13

This gene encodes the testis-determining factor protein (also known as sex-determining region Y protein). Turner syndrome ... male sex-determining) Y chromosome. sSMC are, by definition, smaller in size than one of the smaller human chromosomes, ... This area, termed the PKS critical region, contains three genes, ING4, CHD4, and MFAP5 (also termed the MAGP2 gene), one or ... The exact genetic material in this sSMC that contributes to the development of the cited birth defects has not been determined ...

https://en.wikipedia.org/wiki/Small_supernumerary_marker_chromosome

This gene encodes the testis-determining factor protein (also known as sex-determining region Y protein). Turner syndrome ... All regions of the world and cultures are affected about equally. Generally people with Turner syndrome have a shorter life ... Turner syndrome (TS), also known as 45,X, or 45,X0, is a genetic disorder caused by a sex chromosome monosomy, compared to the ... Ford CE, Jones KW, Polani PE, De Almeida JC, Briggs JH (April 1959). "A sex-chromosome anomaly in a case of gonadal dysgenesis ...

https://en.wikipedia.org/wiki/Turner_syndrome

"A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif". Nature. 346 ( ... "A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed ... "How the Y Chromosome makes a male: Molecular genetic analysis of key sex-determining genes - UQ Researchers". researchers.uq. ... With a growing interest in human variations of sex development (alternatively known as DSD, differences or disorders of sex ...

https://en.wikipedia.org/wiki/Peter_Koopman

19 July 1990). "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif ... The genetic sex is determined by whether a Y bearing or next bearing sperm fertilizes the open; the presence or absence of a Y ... Female sex is determined by the absence of a Y chromosome. Some individuals are male who have the XX male syndrome and androgen ... Genetic sex determines whether the gonads will be testes or ovaries. In the developing embryo if the testes are developed, it ...

https://en.wikipedia.org/wiki/Male_reproductive_system

19 July 1990). "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif ... Having a testis determines maleness, not having a testis determines femaleness. The ovary is not sex-determining. It will not ... the sex of an individual is determined by a pair of sex chromosomes. In most cases, females have two of the same kind of sex ... sex-determining region of the Y chromosome). Sexual differentiation (human) Secondary sex characteristic (human) Y-chromosomal ...

https://en.wikipedia.org/wiki/XY_sex-determination_system

Fraser, JA, Heitman, J (September 2005). "Chromosomal sex-determining regions in animals, plants and fungi". Curr Opin Genet ... Hull, CM, Boily, MJ, Heitman, J (March 2005). "Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate ... "Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms". PLOS Biology. 2 (12): e384. doi ... Wang, X, Hsueh, YP, Li, W, Floyd, A, Skalskey, R, Heitman J (November 2010). "Sex-induced silencing defends the genome of ...

https://en.wikipedia.org/wiki/Joseph_Heitman

The other testis-specific circRNA, sex-determining region Y (Sry), also was found as a miR-138 sponge. About-mentioned examples ... Li, JH; Liu, S; Zhou, H; Qu, LH; Yang, JH (Jan 1, 2014). "starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA ... circRNA has also been shown in viral infection where it sequesters anti-viral protein to enhance viral replication. This ...

https://en.wikipedia.org/wiki/Circular_RNA_databases_and_resources

The main targets in the cffDNA analysis are the gene responsible for the sex-determining region Y protein (SRY) on the Y ... sex-determining region Y gene (SRY) and Y chromosome short tandem repeat "DYS14" in cffDNA from 511 pregnancies were analyzed ... The use of nested polymerase chain reaction (nested PCR) was evaluated to determine sex by detecting a Y chromosome specific ... When assessing the technique, no false positives or negatives were found when looking for cffDNA to determine fetal sex in ...

https://en.wikipedia.org/wiki/Cell-free_fetal_DNA

Differentiation of the gonads begins after the 6th week, which is determined by the sex-determining region Y (SRY) gene in the ... These processes are initiated and regulated by biological metabolites such as DNA, hormones and proteins. The initial steps of ... Hence, examination (typically at birth) is carried out where the sex of the patient will be determined through imaging and ... "Disorders of Sex Development Loci☆". Disorders of Sex Development Loci. Elsevier. doi:10.1016/B978-0-12-809633-8.06552-3. ISBN ...

https://en.wikipedia.org/wiki/Sexual_anomalies

The Y sex-determining transcription factor works to regulate BZW2 expression in the testis. Throughout the body, BZW2 is ... There are four major stem loops in the 5' untranslated and four in the 3' untranslated region that function in transcript-level ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2020-07-31. Koonin EV (August ... The protein rep is part of SARS-CoV-2 virus and inhibits translation of BZW2. BZW2 has been studied to determine its role in ...

https://en.wikipedia.org/wiki/Basic_leucine_zipper_and_W2_domain-containing_protein_2

... also known as sex-determining region Y (SRY) protein that is found on the Y chromosome. He has founded two biotechnology ... "EXCERPT: 'How Sex Works'". ABC News. Miller, Jen A. "Review: 'How Sex Works: Why We Look, Smell, Taste, Feel, and Act the Way ... The SOX3 gene encodes a protein that is similar but distinct to the testis-determining factor (TDF), ... He is the author of the New York Times bestselling book Survival of the Sickest, as well as How Sex Works, Inheritance and The ...

https://en.wikipedia.org/wiki/Sharon_Moalem

... homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins ... "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12". Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008 ... SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription ... The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various ...

https://en.wikipedia.org/wiki/SOX12

... hmgb2 protein MeSH D12.776.660.235.400.600.800 - hmgb3 protein MeSH D12.776.660.235.400.700 - sex-determining region y protein ... hmga proteins MeSH D12.776.660.235.400.500.100 - hmga1a protein MeSH D12.776.660.235.400.500.200 - hmga1b protein MeSH D12.776. ... hmga2 protein MeSH D12.776.660.235.400.600 - hmgb proteins MeSH D12.776.660.235.400.600.300 - hmgb1 protein MeSH D12.776. ... MeSH D12.776.660.235.400.400 - hmgn proteins MeSH D12.776.660.235.400.400.200 - hmgn1 protein MeSH D12.776.660.235.400.400.300 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.660)

... sex-determining HMG box factors, and various homeobox/homeodomain binding sites. The TMEM247 gene codes for a single protein, ... Transmembrane protein 247 has two transmembrane domains. The three regions of the protein that remain are predicted to be ... Notable in the protein are two transmembrane regions near the c-terminus of the translated polypeptide. Transmembrane protein ... Protein kinases may modify transmembrane protein 247, and a variety of sites along the translated protein have been predicted ...

https://en.wikipedia.org/wiki/TMEM247

... screens Sall4 can also bind other important pluripotency proteins such as Nanog and sex determining region Y (SRY)-box 2 ... "The conserved glutamine-rich region of chick csal1 and csal3 mediates protein interactions with other spalt family members. ... metastasis-associated proteins (MTA), methyl-CpG-binding domain proteins (MBD2 or MBD3), and histone deacetylases (HDAC1 and ... protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells". The Journal ...

https://en.wikipedia.org/wiki/SALL4

A gene in the sex-determining region of the short arm of the Y, now referred to as SRY, has been found to direct production of ... a protein, testis determining factor, which binds to DNA, inducing differentiation of cells derived from the genital ridges ... Pokorná, Martina; Kratochvíl, Lukáš (2009-05-01). "Phylogeny of sex-determining mechanisms in squamate reptiles: are sex ... Sex determination is often distinct from sex differentiation; sex determination is the designation for the development stage ...

https://en.wikipedia.org/wiki/Sexual_differentiation

... a gene found in the sex determining region of the Y chromosome of the hoverfly C. piger. DmX is located in region 5D5/6-E1 of ... The motif is likely responsible for protein-protein interactions. In most WD-repeat proteins the motif is repeated four to ... Rabconnectin-3A belongs to the superfamily of WD-repeat proteins which consists of mainly regulatory proteins involved in a ... as indicated by its non-sex-specific expression. DmX encodes for the relatively large protein rabconnectin-3A, which consists ...

https://en.wikipedia.org/wiki/Rabconnectin-3A

IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the ... Jacobs, Patricia A.; Strong, John A. (January 31, 1959). "A case of human intersexuality having a possible XXY sex-determining ... In the wake of the establishment of the normal number of human chromosomes, 47,XYY was the last of the common sex chromosome ... 1982). Children with sex chromosome aneuploidy: follow-up studies. Birth defects original article series 18 (4). New York: Alan ...

https://en.wikipedia.org/wiki/XYY_syndrome

The promoter region of TEX55 has multiple SRY box-6 and SOX/SRY-sex/testis determining and related HMG box transcription factor ... Through function-region analysis, researchers found that this protein may act as an anchoring protein of cAMP-dependent type-II ... This indicates that the sex chromosomes may play a role in post-translational modification and expression. The TEX55 protein ... Analysis done by the Human Protein Atlas indicates that the TEX55 protein can be found not only in the testis, but also the ...

https://en.wikipedia.org/wiki/TEX55

... sex-determining region), ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), AMELY (amelogenin, Y-linked), ANT3Y ( ... Although the Y-chromosome is sex-determining in humans and some other species, not all genes that play a role in sex ... In guppies, Y-linked genes help determine sex selection. This is done indirectly by traits that allow the guppy to appear more ... The Y-chromosome, generally does not undergo genetic recombination and only small regions called pseudoautosomal regions ...

https://en.wikipedia.org/wiki/Y_linkage

... development of the male gonads is primarily controlled by the testis determining factor located on the sex-determining region ... StAR protein) which regulates steroid hormone production. 46,XY gonadal dysgenesis is characteristic of male hypogonadism with ... Bashamboo A, McElreavey K (2015). "Human sex-determination and disorders of sex-development (DSD)". Seminars in Cell & ... XY disorders of sex development (DSD) using a C57BL/6J-Y POS mouse model". Biology of Sex Differences. 9 (8): 8. doi:10.1186/ ...

https://en.wikipedia.org/wiki/Gonadal_dysgenesis

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene- ... "Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex- ... Sex-Determining+Region+Y+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) PDBe-KB provides an ... "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif". Nature. 346 ( ...

https://en.wikipedia.org/wiki/Sex-determining_region_Y_protein

Protein target information for Sex-determining region Y protein (white-tufted-ear marmoset). Find diseases associated with this ...

https://pubchem.ncbi.nlm.nih.gov/protein/P51501

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the ... A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif Nature. 1990 Jul ... This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining ... A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the ...

https://pubmed.ncbi.nlm.nih.gov/1695712/?dopt=Abstract

SRY: sex determining region Y. *ST3GAL5: ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... SYNE1: spectrin repeat containing nuclear envelope protein 1. *SYNGAP1: synaptic Ras GTPase activating protein 1 ...

https://medlineplus.gov/genetics/gene-s/

All astrocytes expressed functional markers including glial fibrillary acidic protein (GFAP), excitatory amino acid transporter ... recombinant monoclonal rabbit IgG sex determining region-1 (SOX1; 1:100; Abcam), monoclonal mouse IgG1 nestin (1:200; Abcam) or ... Revett TJ, Baker GB, Jhamandas J, Kar S . Glutamate system, amyloid β peptides and tau protein: functional interrelationships ... glial fate of embryonic stem cell-derived neural progenitors (ES-NPs) is determined by FGF2/EGF during proliferation. J Mol ...

https://www.nature.com/articles/cddis201789?error=cookies_not_supported&code=2c350866-c875-4518-96f8-000d6f83097d

In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related ... sex-determining region of the Y; Tas, T-associated sex reversal; ts, tail somite; WMISH, wholemount in situ hybridisation ... The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including ... 1990) A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically ...

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000196

Evaluation of sex-determining region Y box 6 and heart development protein with EGF-like domain 1 in differentiating ... The role of heat shock protein 70 and glypican 3 expression in early diagnosis of hepatocellular carcinoma. Mohamed, Said A.; ...

https://journals.lww.com/ejpathology/pages/currenttoc.aspx

Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex ... determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-related HMG-box gene 2 ... SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 ... Recombinant fragment of human SOX2 protein. The antigen corresponds to amino acid range 1-50 of the target protein. View ...

https://www.thermofisher.com/antibody/product/SOX2-Embryonic-Stem-Cell-Marker-Antibody-clone-SOX2-4267R-Recombinant-Monoclonal/6657-RBM7-P1

Protein Aliases: SOX 9; SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-Box 9 ... HF, terminally differentiated fibroblasts; HSerCs, human Sertoli cells; NT2, NT2d1 cells; SOX9, SRY (sex determining region Y)- ... protein kinase activity protein binding beta-catenin binding protein kinase A catalytic subunit binding enhancer binding bHLH ... protein kinase B signaling negative regulation of myoblast differentiation positive regulation of protein catabolic process ...

https://www.thermofisher.com/antibody/product/SOX9-Antibody-clone-1B11-Monoclonal/MA5-17177

DAX1 also appears to function as an antitestis gene by acting antagonistically to the sex-determining region (SRY). [14] In ... Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein ... dosage-sensitive sex reversal adrenal hypoplasia congenita critical region of the X chromosome, also called the NR0B1 gene) on ... and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: ...

https://emedicine.medscape.com/article/918967-overview

The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon ... The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers.. The ... are found in the sex-determining region of the mouse Y chromosome. One or both genes may serve as the primary sex-determining ... located in the sex-determining region of the human Y chromosome, appears to encode a zinc-finger protein. Two homologous genes ...

https://www.wikigenes.org/e/ref/e/2493989.html

OMIM:114290: Campomelic dysplasia with autosomal sex reversal. Sex-determining region Y protein (Q05066) (SMART). OMIM:480000: ... sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [ (PUBMED: ... Three highly conserved regions within each of the known HMG-I proteins is closely related to the consensus sequence T-P-K-R-P-R ... We have determined the domains of the mammalian high mobility group (HMG)I chromosomal proteins necessary and sufficient for ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=HMG&START=1378&END=1448&E_VALUE=2.87e-13&TYPE=SMART&BLAST=KRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDG

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=HMG&START=260&END=326&E_VALUE=1.1e-14&TYPE=SMART&BLAST=PTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLE

Hippocampal NPCs express glial fibrillary acid protein (GFAP), sex determining region Y-box 2 (SOX2; Figure 1), brain lipid- ... They differ in the expression of transcription factors and plasma membrane proteins. They can be used as NPC markers for ... binding protein (BLBP), and nestin (PMID: 21549330). Proliferative NPCs are characterized by the expression of SOX2 and paired ... and microtubule-associated protein 2 (MAP2; Figure 5) (PMID: 26931327). ...

https://www.sanbio.nl/resources/blogs/blog-about-npcs-nscs

SRY (sex determining region Y)-box 9 antibody. *SRY (sex-determining region Y)-box 9 protein antibody ... Country/Region selector. Your country/region is currently set to: If incorrect, please enter your country/region into the box ... The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein ... SRY (sex determining region Y) box 9 antibody. * ... SRY (sex determining region Y) box 9 (campomelic dysplasia ...

https://www.abcam.com/products/primary-antibodies/alexa-fluor-488-sox9-antibody-epr14335-ab196450.html

... sex-determining region Y SRY-box transcription factors 5, 6, and 9; SOX5, SOX6, and SOX9; aggrecan; biglycan; type II, type IX ... monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory proteins-1 (MIP-1α, MIP-1β), regulated upon activation, normal ... The ideal volume of required BMA or BMAC for the treatment of a specific defect volume remains to be determined. ... Fibrin is formed by polymerization through the clotting cascade, generating a mesh of long strands of insoluble protein that ...

https://www.hindawi.com/journals/sci/2017/1609685/

... and the relationship between SOX2 expression and two classical marker proteins of the EMT was analyzed. ... Sex determining region Y-box 2 (SOX2) is a promoter of squamous cell carcinoma (SCC), and high expression of SOX2 is related to ... Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma. ... Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma ...

https://wjgnet.com/2307-8960/articlehighlights/v10/i27/9657.htm

Because only one gene, MID, is present in the male version of the sex-determining region in Eudorina, Hamaji and colleagues ... the evolution of males in volvocine algae might have resulted from altered function of the sex-determining protein MID or its ... That paper showed that the sex-determining region of anisogamous Eudorina is, surprisingly, considerably smaller than the ... Last week, I wrote about Takashi Hamajis new paper characterizing the mating-type/sex-determining loci in Eudorina and ...

https://freethoughtblogs.com/fierceroller/?p=4208

... which then produces a single Sry protein. The Sry protein is also called the testis-determining factor (TDF), a protein that ... The Sry protein is a transcription factor that can bind to regions of testis-specific DNA, bending specific DNA and activating ... The Sry gene, located on the short branch of the Y chromosome, initiates male embryonic development in the XY sex determination ... The Sex-determining Region Y (Sry in mammals but SRY in humans) is a gene found on Y chromosomes that leads to the development ...

https://embryo.asu.edu/pages/sex-determining-region-y-mammals

... homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and ... Protein, Protein Expression, Research, Respiratory, Ribonucleic Acid, RNA, SARS, SARS-CoV-2, Severe Acute Respiratory, Severe ... In the cortical regions of the hemorrhagic specimens, blood vessels situated proximal to erythrocyte clusters showed ... Next, the team examined the counts of cleaved caspase-3+ cells to determine whether the older or recent hemorrhages were ...

https://www.news-medical.net/news/20230125/Study-suggests-cortical-hemorrhage-in-fetal-brain-may-be-associated-with-COVID-19.aspx

Gene ontology (GO) analysis showed that these protein-coding genes were enriched for transcriptional regulation-related terms. ... Genomic analysis identified 250 protein-coding genes located near (≤ 10 kb) 194 of the loci encoding testis-specific ... Spermatogenesis associated glutamate (E)-rich protein 4e. Sry:. Sex determining region of Chr Y ... Table S5. Nearby protein-coding genes located within genomic regions 10 kb up- and downstream of the testis-specific lincRNAs ...

https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4931-3

... sex-determining region Y-box 2 (Sox2) and c-Myc (table 2). At the higher concentration, LIF increased the expression of Sox1 ... qPCR revealed that spheres treated with 5 and 20 ng/ml of LIF had increased expression of Klf4, F-box protein 15 (Fbx15), Nanog ... sex-determining region Y-box 1 (Sox1) and Sox2 primers according to the manufacturers protocol were utilized for quantitative ... To determine the developmental potential of these eight subpopulations, sorted cells were plated onto poly-d-lysine and laminin ...

https://karger.com/dne/article/34/5/449/107578/Leukemia-Inhibitory-Factor-Is-Essential-for

Sex-determining Region Y in Mammals. The Sex-determining Region Y (Sry in mammals but SRY in humans) is a gene found on Y ... Enzymes are types of proteins that can catalyze reactions inside cells, and the figure shows that each enzyme controls a stage ... Sex Determination in Humans. In humans, sex determination is the process that determines the biological sex of an offspring and ... Biological Sex and Gender in the United States. In the United States, most people are assigned both a biological sex and gender ...

https://embryo.asu.edu/search?text=The%20Marine%20Biological%20Laboratory-Woods%20Hole%20Oceanographic%20Institution%20Library&%3Bamp%3Bf%5B0%5D=dc_description_type%3A30&%3Bamp%3Bf%5B1%5D=dc_subject_embryo%3A20&%3Bf%5B0%5D=dc_subject_embryo%3A44&f%5B0%5D=dc_subject_embryo%3A51

Forkhead box protein L2, R-spondin1, Doublesex mab3-related transcription factor 1, and Sex-determining Region on Y chromosome- ... How the physical signal of temperature is transduced into a biological signal that ultimately results in determining gonad sex ... My thesis research focuses on five candidate sex determining genes: cyp19a1 (aromatase), ... Recruitment of modified histone proteins, H3K4me3 and H3K27me3, at the aromatase promoter is FPT-specific during gonad ...

https://repositories.lib.utexas.edu/items/f07906cb-97f9-4ebb-acd9-451c6f0aa9b9

... sex determining region Y)-box 9, Scleraxis, Patched 1, Parathyroid hormone-related protein (PTHrP) and Indian Heddegog (Ihh) ... The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model. J Shoulder ... Adenoviral-mediated gene transfer of human bone morphogenetic protein-13 does not improve rotator cuff healing in a rat model. ... For example, the amount of mineral deposit in the mature enthesis could be determined by the presence of osteogenic factors ...

https://www.wjgnet.com/1948-0210/full/v7/i4/691.htm

BMP2, bone morphogenetic protein 2; SOX9, sex determining region Y-box 9; PPARG, peroxisome proliferator-activated receptor ... d Protein (cytokine) concentrations (pg/mL) in the conditioned media (CM) of 2D and 3D BMSC normalized to corresponding DNA ... For protein-level characterization, conditioned media (CM) from 2D (2D-CM) and 3D BMSC (3D-CM) were collected after culturing ... PLATMC scaffolds were 3D-printed with a pore size of 350-400 μm and total porosity of 53.96% ± 2.91% as determined by µCT. ...

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02642-w

... encodes a 47-kDa protein that is a member of the sex-determining region Y-related high-mobility group-box transcription factor ... To determine cell cycle distribution, 1×106/well MDA-MB-231 or MCF7 cells were collected by trypsinization and fixed in ice- ... RT-qPCR was used to determine the expression levels of miR-320 in the breast cancer cell lines MCF7, T47D, MDA-MB-231 and MDA- ... Specific proteins were detected using an ECL kit (Millipore; Merck KGaA).. Bioinformatic prediction of miR-320 potential ...

https://www.spandidos-publications.com/10.3892/ol.2017.7087

do not confuse entry term SRY SEX-DETERMINING REGION PROTEIN with SRY (SEX DETERMINING REGION Y)-BOX PROTEINS see SOX ... 2006; SEX-DETERMINING REGION Y PROTEIN was indexed under DNA-BINDING PROTEINS & NUCLEAR PROTEINS & TRANSCRIPTION FACTORS 1990- ... Proteins [D12.776] * DNA-Binding Proteins [D12.776.260] * SOX Transcription Factors [D12.776.260.719] * Sex-Determining Region ... SRY Sex-Determining Region Protein Testis-Determining Factor Registry Number. 0. See Also. Genes, sry. Public MeSH Note. ...

https://meshb-prev.nlm.nih.gov/record/ui?ui=D051876

... protein 53; p-Erk, phospho-extracellular signal-regulated kinase; Sox2, SRY (sex determining region Y)-box 2; X-gal, 5-bromo-4- ... Western blot analysis of mammary gland protein lysates shows highly reduced protein levels of E-cad in both Ncad.k.i. and Ncad. ... Western blot analysis of mammary gland protein lysate reveals a approximate 50% decrease of p53 protein level in Ncad.k.i.:p53 ... Additional file 2: Protein expression levels of Ecad and Ncad in Ncad.k.i. and Ncad.k.i.:p53 mammary glands. ...

https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3046

Monotremes lack SRY and some of their sex chromosomes share homology with bird sex chromosomes. (wikipedia.org)
The Sex-determining Region Y ( Sry in mammals but SRY in humans) is a gene found on Y chromosomes that leads to the development of male phenotypes, such as testes. (asu.edu)
Studies by University of Kansas zoologist Clarence Erwin McClung in Lawrence, Kansas at the turn of the twentieth century helped researchers focus on the roles of chromosomes for sex determination. (asu.edu)
In the United States, most people are assigned both a biological sex and gender at birth based on their chromosomes and reproductive organs. (asu.edu)
Humans typically develop as either male or female, primarily depending on the combination of sex chromosomes that they inherit from their parents. (asu.edu)
To understand that, we need to pursue their PSR (paternal sex ratio) chromosomes, perhaps by mutating regions of the PSR chromosome to determine which genes are essential for its functionality. (naturalnews.com)
The Y chromosome is one of two sex chromosomes ( allosomes ) in mammals, including humans , and many other animals. (iiab.me)
Most therian mammals have only one pair of sex chromosomes in each cell. (iiab.me)
Many ectothermic vertebrates have no sex chromosomes. (iiab.me)
The X and Y chromosomes are thought to have evolved from a pair of identical chromosomes, [11] [12] termed autosomes, when an ancestral animal developed an allelic variation, a so-called "sex locus" - simply possessing this allele caused the organism to be male. (iiab.me)
Within the spectrum of DSD, there are varying degrees of discordant genitalia to sex chromosomes. (medscape.com)

SRY is an intronless sex-determining gene on the Y chromosome. (wikipedia.org)
However, there are complications to this hypothesis, because WT1 also is responsible for expression of an antagonist of male development, DAX1, which stands for dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1. (wikipedia.org)
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
In mammals, whether an individual develops as a male or female depends on its sex chromosome constitution: those with a Y chromosome become males because of the development of the embryonic gonad into a testis. (plos.org)
An X-linked form (OMIM 300200) is caused by a mutation or deletion of the DAX1 gene (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region of the X chromosome, also called the NR0B1 gene) on the X chromosome. (medscape.com)
The Sry gene, located on the short branch of the Y chromosome, initiates male embryonic development in the XY sex determination system. (asu.edu)
In humans the first step in the development of an organism's sex is the inheritance of an X chromosome from the mother, and either an X or Y chromosome from the father. (asu.edu)
Based upon her research on sex determination in insect species, Stevens concluded that the Y chromosome carries the genetic material that leads to male development. (asu.edu)
Stevens's work identified the Y chromosome as a heritable structure that somehow caused sex determination in the embryo. (asu.edu)
My thesis research focuses on five candidate sex determining genes: cyp19a1 (aromatase), Forkhead box protein L2, R-spondin1, Doublesex mab3-related transcription factor 1, and Sex-determining Region on Y chromosome-box 9. (utexas.edu)
The SRY-box 4 (SOX4) gene, which is located on chromosome 6p22.3, encodes a 47-kDa protein that is a member of the sex-determining region Y-related high-mobility group-box transcription factor family and has functions in embryonic development and cell differentiation ( 3 , 4 ). (spandidos-publications.com)
Y is normally the sex-determining chromosome in many species, since it is the presence or absence of Y that typically determines the male or female sex of offspring produced in sexual reproduction . (iiab.me)
The Y chromosome was identified as a sex-determining chromosome by Nettie Stevens at Bryn Mawr College in 1905 during a study of the mealworm Tenebrio molitor . (iiab.me)
She realized that the previous idea of Clarence Erwin McClung, that the X chromosome determines sex, was wrong and that sex determination is, in fact, due to the presence or absence of the Y chromosome. (iiab.me)
In those with a Y chromosome, the SRY gene signals the differentiation of primitive sex cords into testes by first signaling the development of Sertoli cells[5]. (loriamedical.com)
Sex-limited inheritance is distinct from X-linked inheritance, which refers to traits carried on the X chromosome. (msdmanuals.com)

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). (wikipedia.org)
Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype. (wikipedia.org)
SRY is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. (wikipedia.org)
SRY is a quickly evolving gene, and its regulation has been difficult to study because sex determination is not a highly conserved phenomenon within the animal kingdom. (wikipedia.org)
while the core of the gene, the high-mobility group (HMG) box, is conserved between species, other regions of the gene are not. (wikipedia.org)
Deletion of the gene resulted in complete sex reversal. (wikipedia.org)
This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF. (nih.gov)
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY . (plos.org)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
Analysis of embryonic XY gonads suggests that sex reversal is caused by delayed and reduced expression of the sex-determining gene SRY . (plos.org)
DAX1 also appears to function as an antitestis gene by acting antagonistically to the sex-determining region (SRY). (medscape.com)
Many of these proteins are regulators of gene expression. (embl.de)
1069\663\AAR10362.1\Arctocephalus gazella\Arctocephalus gazella sex determining region Y protein (SRY) gene,complete cds. (or.jp)
It's somewhat surprising that a single gene can cause Volvox to switch sexes, but at least Volvox MID evolved side-by-side with the genes whose expression it controls. (freethoughtblogs.com)
the DNA encoding the gene is transcribed into messenger RNA, which then produces a single Sry protein. (asu.edu)
These techniques enabled researchers to describe the mechanisms that underlie developmental pathways, including the role of SRY gene in sex determination. (asu.edu)
The scientists claimed that the gene would encode for the testis-determining factor (TDF), a protein responsible for causing testis to develop in embryos. (asu.edu)
The gene, designated the Sex-determining region Y, provided a candidate for expression of the TDF. (asu.edu)
Robin Lovell-Badge and her team at the National Institute for Medical Research later confirmed Sry gene's role in sex determination in an experiment where researchers injected Sry gene sequences into chromosomally female (XX) mice embryos during early embryonic development, and the embryos developed into males. (asu.edu)
Gene ontology (GO) analysis showed that these protein-coding genes were enriched for transcriptional regulation-related terms. (biomedcentral.com)
Molecular characterization included genotyping by sequencing variable regions of the PorA protein gene, ( 2 ), multilocus sequence typing (MLST) ( 3 ), and FetA protein variable region gene characterization ( 4 ). (cdc.gov)
The NT gene (NTS) was sequenced for potential functional variants, evaluating its entire genomic and potentially regulatory regions, in DNA from 28 individuals, stratified by low and high pro-NT levels. (lu.se)
A total of seven sequence variations across the NTS gene, none of them located in coding regions, were identified. (lu.se)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
Sex-limited inheritance, perhaps more correctly called sex-influenced inheritance, refers to special cases in which sex hormones and other physiologic differences between males and females alter the expressivity and penetrance of a gene. (msdmanuals.com)

SRY has little in common with sex determination genes of other model organisms, therefore, mice are the main model research organisms that can be utilized for its study. (wikipedia.org)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
One or both genes may serve as the primary sex-determining signal in mice. (wikigenes.org)
the evolution of males in volvocine algae might have resulted from altered function of the sex-determining protein MID or its target genes. (freethoughtblogs.com)
Genomic analysis identified 250 protein-coding genes located near (≤ 10 kb) 194 of the loci encoding testis-specific lincRNAs. (biomedcentral.com)
However, although numerous studies have investigated the protein-coding genes that show tissue-specific expression and play important roles during spermatogenesis, no previous study has comprehensively identified and characterized the mouse testis-specific lncRNAs. (biomedcentral.com)
The Human Genome Project has revealed that protein-coding genes represent less than 2% of the total genome sequence [ 7 ], and the remaining greater portion of human genomes are regarded as "junk DNAs", for they do not encode any protein. (oncotarget.com)
Whole exome sequencing of patients who experienced severe influenza reveals several genes, including scaffold protein AHNAK, with predicted loss-of-function variants that are also identified in our proteomic analyses. (cdc.gov)

When complexed with the (SF-1) protein, SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. (wikipedia.org)
Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
SOX9 has a role in sex determination and differentiation of Sertoli cells. (thermofisher.com)

Even within marsupials and placentals, which use SRY in their sex determination process, the action of SRY differs between species. (wikipedia.org)
Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. (plos.org)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
In humans, sex determination is the process that determines the biological sex of an offspring and, as a result, the sexual characteristics that they will develop. (asu.edu)
Recruitment of modified histone proteins, H3K4me3 and H3K27me3, at the aromatase promoter is FPT-specific during gonad determination. (utexas.edu)

We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)

On the C57BL/6J background, embryos homozygous for byg exhibit consistent XY gonadal sex reversal. (plos.org)
We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)

Mutations in this region result in sex reversal, where the opposite sex is produced. (wikipedia.org)
Mutations of SF1 can lead to sex reversal, and deletion can lead to incomplete gonad development. (wikipedia.org)
An additional copy of DAX1 in mice leads to sex reversal. (wikipedia.org)
Finally, we provide evidence that haploinsufficiency for Map3k4 accounts for T-associated sex reversal ( Tas ). (plos.org)
Excess expression of DAX1 in the male mouse results in reversal of phenotypic sex. (medscape.com)
In contrast to DAX1 mutations, however, the phenotype in SF1 defects extends to XY sex reversal (ie, XY karyotype and female external genital appearance), persistence of müllerian structures in XY individuals, and failure of gonadal development (streak gonads). (medscape.com)

Although lncRNAs cannot encode any functional protein, they are involved in diverse biological processes, playing essential roles in maintaining cell growth, differentiation and proliferation [ 13 - 15 ]. (oncotarget.com)
Sex differentiation of the external genitalia occurs between the 7th and 17th weeks of gestation. (loriamedical.com)
External genital differentiation into the male sex begins in the 7th week of gestation and is completed by 16-17 weeks[1,2,3]. (loriamedical.com)

It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)

Recombinant fragment of human SOX2 protein. (thermofisher.com)
Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. (thermofisher.com)
SARS-CoV-2 spike (S) expression was sparse in cortical microtubule-associated protein 2 (MAP2)-positive and HuC/D-positive neurons and the nestin-positive and Hopx (homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and subventricular zone progenitor cells. (news-medical.net)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
How the physical signal of temperature is transduced into a biological signal that ultimately results in determining gonad sex is not known. (utexas.edu)

We created recombinant proteins corresponding to the five non-synonymous mutations encountered and found that the Ser268Pro (rs150625869) mutation lead to loss of M-ficolin production. (nih.gov)

A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (bvsalud.org)

However, there is an important distinction between biological sex and gender. (asu.edu)
We will use our established experimental models of obesity to determine how microglia in specific regions of the brain change with high fat diet, including interrogation of protein pathways and biological sex. (edu.au)

It's been shown that binding of three transcription factors, steroidogenic factor 1 (SF1), specificity protein 1 (Sp1 transcription factor) and Wilms tumor protein 1 (WT1), to the human promoter sequence, influence expression of SRY. (wikipedia.org)
WT1 is transcription factor that has four C-terminal zinc fingers and an N-terminal Pro/Glu-rich region and primarily functions as an activator. (wikipedia.org)
The Sry protein is a transcription factor that can bind to regions of testis-specific DNA, bending specific DNA and activating or enhancing its abilities to promote testis formation, marking the first step towards male, rather than female, development in the embryo. (asu.edu)

The only conserved group in mice and other mammals is the HMG box region that is responsible for DNA binding. (wikipedia.org)
The Sry protein is also called the testis-determining factor (TDF), a protein that initiates male development in humans, placental mammals, and marsupials. (asu.edu)

Therefore, an improved understanding of the functions and the underlying molecular mechanisms of these proteins, particularly in epithelial-mesenchymal transition, may provide novel insights into the breast tumorigenesis and progression, and enable the development of effective anti-cancer therapeutics. (spandidos-publications.com)
Fetuin-A may provide novel insights into mechanisms underlying sex differences in glucose homeostasis and diabetes risk in old age. (diabetesjournals.org)

The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)

The aim of this study was to determine the possible genetic regulation of plasma pro-NT. (lu.se)

The Act further directs that where feasible, ATSDR shall develop methods to determine the health effects of substances in combination with other substances with which they are commonly found. (cdc.gov)

Gender is a category created to demonstrate that the an agreement between the nutritional status evaluation vast majority of differences between the sexes are socially criteria, and the mementos that can be used for clinical and culturally constructed from differentiated social roles, research and follow-up of children in the Brazilian and that in the patriarchal order, poles of domination and Amazon region13. (bvsalud.org)

This study evaluated the sex-specific association of plasma fetuin-A levels with prevalent and incident type 2 diabetes in community-dwelling older adults. (diabetesjournals.org)
There were significant interactions of fetuin-A by sex for prevalent ( P = 0.007) and incident ( P = 0.020) diabetes. (diabetesjournals.org)

CD44 is a multifunctional cell surface adhesion molecule that acts as an integral cell membrane protein and plays a role in cell-cell and cell-matrix interactions. (biomedcentral.com)
Review: Evaluation of pancreatic cancer stem cells-related markers CD133, CD44, Oct4, and Nestin proteins in PANC-1 and SW1990 cells by western blotting. (cusabio.com)

[ 13 ] DAX1 appears to suppress expression of the SF1- regulated steroidogenic acute regulatory (StAR) protein promoter. (medscape.com)

Understanding its regulation is further complicated because even between mammalian species, there is little protein sequence conservation. (wikipedia.org)

Last week, I wrote about Takashi Hamaji's new paper characterizing the mating-type/sex-determining loci in Eudorina and Yamagishiella . (freethoughtblogs.com)
That paper showed that the sex-determining region of anisogamous Eudorina is, surprisingly, considerably smaller than the mating-type loci of isogamous Chlamydomonas , Gonium , or Yamagishiella . (freethoughtblogs.com)

They differ in the expression of transcription factors and plasma membrane proteins. (sanbio.nl)
Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. (cusabio.com)
Other factors which determine whether policies are adopted include public perceptions of the risks and benefits involved, the extent to which risks are distributed, and the degree of inequality as to outcomes. (who.int)
3 in determining the outcomes and factors indicative of outcomes for patients with COVID-19. (who.int)
Any other risk factors determined at the discretion of the investigators. (who.int)

Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. (wikipedia.org)

We already knew that MID is necessary and sufficient for male development: genetically male Volvox carteri colonies that have MID expression turned off produce eggs, and genetically female colonies transformed with MID produce sperm packets (" Sex change (in Volvox )") . (freethoughtblogs.com)
4.Healthy male and female participants at enrollment who are determined by medical history, PE, and clinical judgment of the investigator to be eligible for inclusion in the study. (who.int)

In vitro studies of human SRY promoter have shown that a region of at least 310 bp upstream to translational start site are required for SRY promoter function. (wikipedia.org)
The promoter region has two Sp1 binding sites, at -150 and -13 that function as regulatory sites. (wikipedia.org)
The promoter region also has two WT1 binding sites at -78 and -87 bp from the ATG codon. (wikipedia.org)
Four of those polymorphisms were located in the promoter region and exon 1 and were in high linkage disequilibrium (r(2)≥0.91). (nih.gov)

Even more unusual is the breed of goats that have been genetically engineered by Wyoming scientists to produce a spider silk protein in their milk. (naturalnews.com)
If they have different sexes, sex is determined environmentally rather than genetically. (iiab.me)

Octamer-binding protein 4 (Oct-4) is a molecular marker for stem cells that plays an essential role in maintaining pluripotency and self-renewal processes in various types of benign and malignant tissues. (biomedcentral.com)

Figure 1), brain lipid-binding protein (BLBP), and nestin (PMID: 21549330). (sanbio.nl)
We will employ transgenic approaches to specifically manipulate microglia and determine how this alters whole-body metabolic homeostasis and insulin sensitivity in both peripheral organs and the brain before weight gain and during established obesity. (edu.au)
It is expressed at relatively low levels compared with other Fos family proteins in response to acute stimuli, but accumulates to high levels in brain after chronic stimulation because of its unique stability ( Nestler, 2008 ). (jneurosci.org)
See Pediatric Concussion and Other Traumatic Brain Injuries , a Critical Images slideshow, to help identify the signs and symptoms of TBI, determine the type and severity of injury, and initiate appropriate treatment. (medscape.com)

This new technology would allow the team to inject components such as proteins and RNA into an organism . (naturalnews.com)

Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for each compound. (who.int)

High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases. (cdc.gov)

Accordingly, increasing evidence suggests that ΔFosB induction in this region increases an animal's sensitivity to the rewarding effects of drugs of abuse and may also increase motivation to obtain them. (jneurosci.org)

Oral lymphangiomas do not express Wilms tumor 1 protein (WT1), which is consistent with the finding that oral lymphangiomas are not true neoplasms. (medscape.com)

The antigen corresponds to amino acid range 1-50 of the target protein. (thermofisher.com)

If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (abcam.com)

We found an increased expression of Nestin and GAP43 (growth associated protein 43) in treated cells. (cusabio.com)

Anatomy1

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes6

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Health Care1

Linear SRY transcript in equine testis. (1/289)

From head to toes: the multiple facets of Sox proteins. (2/289)

Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. (3/289)

Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding. (4/289)

The human SRY protein is present in fetal and adult Sertoli cells and germ cells. (5/289)

Isolation and characterization of a mouse SRY-related cDNA, mSox7. (6/289)

Bone marrow as a potential source of hepatic oval cells. (7/289)

Mammalian Y chromosome evolution and the male-specific functions of Y chromosome-borne genes. (8/289)

Sex-Determining Region Y Protein

HMGA1a Protein

Genes, sry

SOXB1 Transcription Factors

Sex Determination Analysis

High Mobility Group Proteins

Sulfobromophthalein

Molecular Sequence Data

Base Sequence

Amino Acid Sequence

Sex Factors

Sex Characteristics

Sex

Y Chromosome

Linear SRY transcript in equine testis. (1/289)

From head to toes: the multiple facets of Sox proteins. (2/289)

Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. (3/289)

Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding. (4/289)

The human SRY protein is present in fetal and adult Sertoli cells and germ cells. (5/289)

Isolation and characterization of a mouse SRY-related cDNA, mSox7. (6/289)

Bone marrow as a potential source of hepatic oval cells. (7/289)

Mammalian Y chromosome evolution and the male-specific functions of Y chromosome-borne genes. (8/289)

Sex-determining region Y protein

SOX30

SOX15

SOX14

High-mobility group

Elizabeth Fisher (neuroscientist)

ZFY

David C. Page

SOX13

Small supernumerary marker chromosome

Turner syndrome

Peter Koopman

Male reproductive system

XY sex-determination system

Joseph Heitman

Circular RNA databases and resources

Cell-free fetal DNA

Sexual anomalies

Basic leucine zipper and W2 domain-containing protein 2

Sharon Moalem

SOX12

List of MeSH codes (D12.776.660)

TMEM247

SALL4

Sexual differentiation

Rabconnectin-3A

XYY syndrome

TEX55

Y linkage

Gonadal dysgenesis

Sex-determining region Y protein - Wikipedia

Sex-determining region Y protein (white-tufted-ear marmoset) | Protein Target - PubChem

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

MedlinePlus: Genes: S

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WikiGenes

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SMART: HMG domain annotation

Markers of neuronal precursor cells / neural stem cells | blog by Sanbio

Alexa Fluor® 488 Anti-SOX9 antibody [EPR14335] (ab196450) | Abcam

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Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma

Origins of the sexes: more on MID

Sex-determining Region Y in Mammals

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

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Search | The Embryo Project Encyclopedia

Genetic networks and epigenetic mechanisms of temperature-dependent sex determination in the red-eared slider turtle, Trachemys...

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MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4

MeSH Browser