A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.
A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
I'm sorry for any confusion, but "Brazil" is not a medical term or concept, it is a country located in South America, known officially as the Federative Republic of Brazil. If you have any questions related to health, medicine, or science, I'd be happy to help answer those!
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
An abnormal elevation of body temperature, usually as a result of a pathologic process.

Changing epidemiology of dengue hemorrhagic fever in Thailand. (1/325)

Dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) are reportable diseases, the third most common causes for hospitalization of children in Thailand. Data collected from the Ministry of Public Health were analysed for trends. Rates of DHF increased in Thailand until 1987 when the largest epidemic ever, 325/100000 population, was recorded. Whereas the disease used to be confined to large cities, the rate is now higher in rural (102.2 per 100000) than urban areas (95.4 per 100000 in 1997). The age of highest incidence has increased, and the age group most severely affected is now those 5-9 years old (679/100000 in 1997). The case fatality rate has decreased with improved treatment and is now only 0.28%.  (+info)

Impaired T cell proliferation in acute dengue infection. (2/325)

Decreased proliferative responses to mitogens and recall Ags have been observed in PBMC obtained during several acute human viral infections. To determine whether cell-mediated responses are altered during acute dengue infection, we examined the proliferative responses of PBMC from children enrolled in a prospective study of dengue infections in Thailand. All responses of PBMC during acute illness were compared with the same patients' PBMC obtained at least 6 mo after their infection. Proliferative responses to PHA, anti-CD3, tetanus toxoid, and dengue Ags were decreased significantly in PBMC obtained during the acute infection. The proliferative responses to PHA were restored by the addition of gamma-irradiated autologous convalescent or allogeneic PBMC. Cell contact with the irradiated PBMC was necessary to restore proliferation. Non-T cells from the acute PBMC of dengue patients did not support proliferation of T cells from control donors in response to PHA, but T cells from the PBMC of patients with acute dengue proliferated if accessory cells from a control donor were present. Addition of anti-CD28 Abs restored anti-CD3-induced proliferation of the PBMC of some patients. The percentage of monocytes was reduced in the acute sample of PBMC of the dengue patients. Addition of IL-2 or IL-7, but not IL-4 or IL-12, also restored proliferation of acute PBMC stimulated with anti-CD3. The results demonstrate that both quantitative and qualitative defects in the accessory cell population during acute dengue illness result in a depression of in vitro T cell proliferation.  (+info)

Evaluation of four methods for detection of immunoglobulin M antibodies to dengue virus. (3/325)

Dengue has become hyperendemic in many islands of the Caribbean region. The performance in a diagnostic laboratory of four commercial assays for detection of immunoglobulin M (IgM) antibodies was evaluated. Sera from 62 patients with dengue virus infection were studied. These included 18 patients from whom dengue virus type 2 was isolated in a 1997 outbreak (specimens collected a mean of 14 days after onset of symptoms), 8 patients with dengue hemorrhagic fever (mean time after onset, 11 days), and 36 patients in whom dengue was previously confirmed by serology (mean time after onset, 10 days). Thirty serum specimens from blood donors in a country where dengue is not endemic were used as negative controls. The methods evaluated were two IgM-capture enzyme-linked immunosorbent assays (ELISA) (MRL Diagnostics, Cypress, Calif., and PanBio, Queensland, Australia), a dot ELISA dipstick assay (Integrated Diagnostics, Baltimore, Md.), and a rapid immunochromatographic assay for dengue IgG and IgM (PanBio IC). IgG antibodies were also detected by an ELISA method (MRL Diagnostics). The sensitivities of the four assays were as follows: MRL Diagnostics IgM ELISA, 98.4%; PanBio IgM ELISA, 85.5%; Integrated Diagnostics IgM dot ELISA, 96. 8%; and PanBio IC, 83.9%. The specificities of all tests were 100%. Evidence of secondary dengue was found in all patients with dengue hemorrhagic fever and in 83% of the remaining patients. The MRL Diagnostics IgM ELISA appears to be more sensitive than the PanBio IgM ELISA, and this may be significant when IgM titers are low, particularly in patients with secondary dengue infections. The dot ELISA dipstick assay is equally sensitive and may be more appropriate for use in laboratories with lower workloads.  (+info)

Total immunoglobulin E levels and dengue infection on San Andres Island, Colombia. (4/325)

An evaluation of total immunoglobulin E (IgE) and dengue serostatus in 168 subjects from San Andres Island, Colombia, revealed altered levels of IgE in 89% of the population. IgE levels were higher in patients with a history of dengue or with a current secondary or current primary infection than in subjects with no exposure (P = 0. 01). Dengue infection accounted for 23% of the variation in IgE levels.  (+info)

Type-3 dengue viruses responsible for the dengue epidemic in Malaysia during 1993-1994. (5/325)

To characterize the dengue epidemic that recently occurred in Malaysia, we sequenced cDNAs from nine 1993-1994 dengue virus type-3 (DEN-3) isolates in Malaysia (DEN-3 was the most common type in Malaysia during this period). Nucleic acid sequences (720 nucleotides in length) from the nine isolates, encompassing the precursor of membrane protein (preM) and membrane (M) protein genes and part of the envelope (E) protein gene were aligned with various reference DEN-3 sequences to generate a neighbor-joining phylogenetic tree. According to the constructed tree, the nine Malaysian isolates were grouped into subtype II, which comprises Thai isolates from 1962 to 1987. Five earlier DEN-3 virus Malaysian isolates from 1974 to 1981 belonged to subtype I. The present data indicate that the recent dengue epidemic in Malaysia was due to the introduction of DEN-3 viruses previously endemic to Thailand.  (+info)

The first major outbreak of dengue hemorrhagic fever in Delhi, India. (6/325)

India An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHS/DSS) occurred in 1996 in India in and near Delhi. The cause was confirmed as dengue virus type 2, by virus cultivation and indirect immunofluorescence with type-specific monoclonal antibodies. This is the largest such outbreak reported from India, indicating a serious resurgence of dengue virus infection.  (+info)

Profile of transforming growth factor-beta 1 in patients with dengue haemorrhagic fever. (7/325)

The pathogenesis of dengue haemorrhagic fever (DHF) is incompletely understood but it has been suggested that various cytokines may have a role in the process. In this study the profile of the cytokine Transforming Growth Factor-beta 1 (TGF-beta1) was investigated in the sera of 79 patients with various grades of dengue illness and in 21 normal healthy controls. Also, TGF-beta1-specific mRNA was examined in their peripheral blood mononuclear cells (PBMC). The results showed that neither TGF-beta1 protein nor its mRNA were detected in healthy controls. In dengue patients, the TGF-beta1 protein and its mRNA were detected in 96%. However, among the patient groups, the levels of TGF-beta1 were lowest in patients with dengue fever (DF; mean value 315 +/- 95 pg/ml) and were highest in patients with DHF grade IV (mean value 1350 +/- 280 pg/ml; P = < 0. 001). The cytokine appeared during the first four days of illness (304 +/- 90 pg/ml) and gradually increased, reaching peak levels (1050 +/- 215 pg/ml) after the 9th day of the illness. Thus TGF-beta1 in the sera and TGF-beta1-mRNA in the PBMC were present in most of the patients with dengue (96%) but the cytokine levels were highest during the later periods of illness and in patients with DHF grade IV, suggesting a possible role of TGF-beta1 in the pathogenesis of DHF.  (+info)

A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995-1996. (8/325)

A prospective study on dengue (DEN) viruses was initiated in October 1995 in Gondokusuman kecamatan, Yogyakarta, Indonesia. This report presents data from the first year of the study. The studied cohort included all children 4-9 years of age living in the kecamatan. Blood samples for serology were collected from 1,837 children in October 1995 and again in October 1996. Blood samples for virus isolation and serology were collected from cohort children who were seen in municipal health clinics with febrile syndromes or admitted to hospitals with a provisional diagnosis of dengue hemorrhagic fever. Dengue serotype antibody prevalence and 1995-1996 infection rates were calculated using a single dilution (1:60) 70% plaque reduction endpoint neutralization test. Prevalence of dengue antibody at the beginning of the study was DEN 1 = 12%, DEN 2 = 16%, DEN 3 = 2%, DEN 4 = 4%, and two or more dengue infections = 22%. Total dengue antibody prevalence increased from 38% in 4-year-old children to 69% in 9-year-old children. During the observation period, primary dengue infection rates were DEN 1 = 4.8%, DEN 2 = 7.7%, DEN 3 = 4.2%, and DEN 4 = 3.4%, while two or more dengue infections occurred in 6.7% of the study population. The secondary dengue infection rate was 19.0%. From febrile cases, all four dengue viruses were isolated with DEN 3 predominating. Seven children were hospitalized, including one fatal case with a hospital diagnosis of dengue shock syndrome. Based upon presence of antibody in the initial cohort bleeding and the serologic response both weeks and several months following illness, all had secondary dengue infections. Neutralizing antibody patterns in the initial cohort bleeding and in late convalescent serum samples permitted recognition of dengue infection sequence in five patients: DEN 2-DEN 1 (3), DEN 2-DEN 4 (1), DEN 1-DEN 3 (1), and none in the sequence DEN 1-DEN 2. In the total cohort 6.5% of the observed secondary infections were of the sequence DEN 2-DEN 1, while 4.9% were DEN 1-DEN 2, a highly pathogenic sequence in previous studies. Reduced pathogenic expression of secondary DEN 2 with enhanced pathogenic expression of secondary DEN 1 infections was an unexpected finding. Further studies will be required to understand the respective contributions to pathogenicity of antibody from initial dengue infections versus the biological attributes of the second infecting dengue viruses.  (+info)

Severe dengue, also known as dengue hemorrhagic fever, is a severe and potentially fatal complication of dengue virus infection. The World Health Organization (WHO) defines it as follows:

"Dengue hemorrhagic fever is characterized by a high fever (40°C/104°F) that lasts for 2-7 days, with generalized pain and severe headache, bleeding manifestations (e.g., nose or gum bleed, skin rash with bruising, internal bleeding), plasma leakage leading to accumulation of fluid in the lungs or abdomen, and a rapid decrease in platelet count."

Severe dengue can be life-threatening if not diagnosed and treated promptly. It is important to seek medical attention immediately if you suspect you have dengue fever and are experiencing any of the symptoms associated with severe dengue.

Dengue is a mosquito-borne viral infection that is primarily transmitted by the Aedes aegypti and Aedes albopictus species of mosquitoes. It is caused by one of four closely related dengue viruses (DENV 1, DENV 2, DENV 3, or DENV 4). The infection can cause a wide range of symptoms, ranging from mild fever and headache to severe flu-like illness, which is often characterized by the sudden onset of high fever, severe headache, muscle and joint pain, nausea, vomiting, and skin rash. In some cases, dengue can progress to more severe forms, such as dengue hemorrhagic fever or dengue shock syndrome, which can be life-threatening if not treated promptly and appropriately.

Dengue is prevalent in many tropical and subtropical regions around the world, particularly in urban and semi-urban areas with poor sanitation and inadequate mosquito control. There is no specific treatment for dengue, and prevention efforts focus on reducing mosquito populations and avoiding mosquito bites. Vaccines are available in some countries to prevent dengue infection, but they are not widely used due to limitations in their effectiveness and safety.

Dengue virus (DENV) is a single-stranded, positive-sense RNA virus that belongs to the genus Flavivirus in the family Flaviviridae. It is primarily transmitted to humans through the bites of infected female mosquitoes, mainly Aedes aegypti and Aedes albopictus.

The DENV genome contains approximately 11,000 nucleotides and encodes three structural proteins (capsid, pre-membrane/membrane, and envelope) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). There are four distinct serotypes of DENV (DENV-1, DENV-2, DENV-3, and DENV-4), each of which can cause dengue fever, a mosquito-borne viral disease.

Infection with one serotype provides lifelong immunity against that particular serotype but only temporary and partial protection against the other three serotypes. Subsequent infections with different serotypes can increase the risk of developing severe dengue, such as dengue hemorrhagic fever or dengue shock syndrome, due to antibody-dependent enhancement (ADE) and original antigenic sin phenomena.

DENV is a significant public health concern in tropical and subtropical regions worldwide, with an estimated 390 million annual infections and approximately 100-400 million clinical cases. Preventive measures include vector control strategies to reduce mosquito populations and the development of effective vaccines against all four serotypes.

Antibody-Dependent Enhancement (ADE) is a phenomenon in which the presence of antibodies against a particular virus actually enhances the ability of the virus to infect and replicate within host cells, leading to increased severity of infection. This occurs when the antibodies bind to the virus but do not neutralize it, instead facilitating uptake of the virus into immune cells expressing Fc receptors, such as macrophages. The virus can then use these cells as a site for replication and evasion of the host's immune response. ADE has been observed in various viral infections, including dengue fever and respiratory syncytial virus (RSV) infection. It is a concern in the development of vaccines against these viruses, as non-neutralizing antibodies induced by vaccination could potentially enhance subsequent infection with a heterologous strain of the virus.

I'm sorry for any confusion, but "Indonesia" is not a medical term. It is a country located in Southeast Asia and Oceania, between the Indian and Pacific oceans. It is the world's largest island country, with more than thirteen thousand islands. If you have any questions about medical terms or concepts, I would be happy to help with those!

I'm sorry for any confusion, but "Thailand" is not a medical term. It is a country located in Southeast Asia. If you have any questions about medical terms or concepts, I would be happy to help answer those for you!

"Aedes" is a genus of mosquitoes that are known to transmit various diseases, including Zika virus, dengue fever, chikungunya, and yellow fever. These mosquitoes are typically found in tropical and subtropical regions around the world. They are distinguished by their black and white striped legs and thorax. Aedes aegypti is the most common species associated with disease transmission, although other species such as Aedes albopictus can also transmit diseases. It's important to note that only female mosquitoes bite and feed on blood, while males feed solely on nectar and plant juices.

A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.

Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.

It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

Dengue vaccines are designed to protect against dengue fever, a mosquito-borne viral disease that can cause severe flu-like symptoms and potentially life-threatening complications. Dengue is caused by four distinct serotypes of the virus (DENV-1, DENV-2, DENV-3, and DENV-4), and infection with one serotype does not provide immunity against the others.

The first licensed dengue vaccine, Dengvaxia (CYD-TDV), is a chimeric yellow fever-dengue tetravalent vaccine developed by Sanofi Pasteur. It is approved for use in several countries and has demonstrated efficacy against dengue fever caused by all four serotypes in clinical trials. However, the vaccine has raised concerns about the risk of severe disease in individuals who have not been previously exposed to dengue. As a result, it is recommended primarily for people with a documented past dengue infection or living in areas with high dengue prevalence and where the benefits outweigh the risks.

Another dengue vaccine candidate, Takeda's TAK-003 (also known as TDV), is a live attenuated tetravalent dengue vaccine that has shown efficacy against all four serotypes in clinical trials. It was granted approval by the European Medicines Agency (EMA) and several other countries for use in individuals aged 4-16 years old, living in endemic areas.

Research and development of additional dengue vaccine candidates are ongoing to address concerns about safety, efficacy, and accessibility, particularly for at-risk populations in low- and middle-income countries where dengue is most prevalent.

I apologize, but "Brazil" is not a medical term or condition. It is the largest country in both South America and Latin America by land area and population. If you have any questions related to medical terminology or health concerns, please provide more information and I will do my best to help.

Insect vectors are insects that transmit disease-causing pathogens (such as viruses, bacteria, parasites) from one host to another. They do this while feeding on the host's blood or tissues. The insects themselves are not infected by the pathogen but act as mechanical carriers that pass it on during their bite. Examples of diseases spread by insect vectors include malaria (transmitted by mosquitoes), Lyme disease (transmitted by ticks), and plague (transmitted by fleas). Proper prevention measures, such as using insect repellent and reducing standing water where mosquitoes breed, can help reduce the risk of contracting these diseases.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Hypotension is a medical term that refers to abnormally low blood pressure, usually defined as a systolic blood pressure less than 90 millimeters of mercury (mm Hg) or a diastolic blood pressure less than 60 mm Hg. Blood pressure is the force exerted by the blood against the walls of the blood vessels as the heart pumps blood.

Hypotension can cause symptoms such as dizziness, lightheadedness, weakness, and fainting, especially when standing up suddenly. In severe cases, hypotension can lead to shock, which is a life-threatening condition characterized by multiple organ failure due to inadequate blood flow.

Hypotension can be caused by various factors, including certain medications, medical conditions such as heart disease, endocrine disorders, and dehydration. It is important to seek medical attention if you experience symptoms of hypotension, as it can indicate an underlying health issue that requires treatment.

Fever, also known as pyrexia or febrile response, is a common medical sign characterized by an elevation in core body temperature above the normal range of 36.5-37.5°C (97.7-99.5°F) due to a dysregulation of the body's thermoregulatory system. It is often a response to an infection, inflammation, or other underlying medical conditions, and it serves as a part of the immune system's effort to combat the invading pathogens or to repair damaged tissues.

Fevers can be classified based on their magnitude:

* Low-grade fever: 37.5-38°C (99.5-100.4°F)
* Moderate fever: 38-39°C (100.4-102.2°F)
* High-grade or severe fever: above 39°C (102.2°F)

It is important to note that a single elevated temperature reading does not necessarily indicate the presence of a fever, as body temperature can fluctuate throughout the day and can be influenced by various factors such as physical activity, environmental conditions, and the menstrual cycle in females. The diagnosis of fever typically requires the confirmation of an elevated core body temperature on at least two occasions or a consistently high temperature over a period of time.

While fevers are generally considered beneficial in fighting off infections and promoting recovery, extremely high temperatures or prolonged febrile states may necessitate medical intervention to prevent potential complications such as dehydration, seizures, or damage to vital organs.

Severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage while all ... Climate change and infectious diseases#Dengue fever "Dengue and severe dengue Fact sheet N°117". WHO. May 2015. Archived from ... The 1997 classification divided dengue into an undifferentiated fever, dengue fever, and dengue hemorrhagic fever. Dengue ... "Dengue and severe dengue". www.who.int. Retrieved 15 December 2019. Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, ...
"Dengue and severe dengue". www.who.int. Retrieved 2022-10-28. Guha-Sapir, Debarati; van Panhuis, Willem Gijsbert (December 2009 ... "Emergence of Genotype I of Dengue Virus Serotype 3 during a Severe Dengue Epidemic in Sri Lanka in 2017". Japanese Journal of ... In the 2017 dengue epidemic in Sri Lanka, a rise in the number of dengue fever cases was reported on the island country of Sri ... 2022 has seen an economic crisis and severe food insecurity in Sri Lanka, the dengue outbreak would be a contributing factor. ...
... recommends that countries should consider vaccination with the dengue vaccine CYD-TDV only if the risk of severe dengue in ... Dengue vaccine is a vaccine used to prevent dengue fever in humans. Development of dengue vaccines began in the 1920s, but was ... The value of Dengavaxia is limited by the fact that it may increase the risk of severe dengue in those who have not previously ... In both trials vaccine reduced by about 80% the number of severe dengue cases. An analysis of both the Latin American and Asian ...
... dengue hemorrhagic fever and dengue shock syndrome are the severe forms. Dengue is found in tropical and subtropical climates ... "Dengue and severe dengue". World Health Organization (WHO). 17 March 2023. Retrieved 8 October 2023. DISTRICT OF COLUMBIA ... dengue shock syndrome). A common problem faced in dengue-endemic regions is when mothers become infected with dengue; after ... Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family ...
1 of 20 individuals who become ill with dengue will develop severe dengue. Severe dengue can lead to life-threatening condition ... Dengue fever sufferers have an approximate 1% chance of progressing to the more severe dengue hemorrhagic fever. ... Those infected experience flu-like symptoms such as severe headaches, fevers and joint pain. 1 of 4 people infected with dengue ... On 20 February, the Pan American Health Organization reported that eighty (80) cases of the more severe dengue hemorrhagic ...
"Dengue and severe dengue". World Health Organization (WHO). 2 March 2020. "WHO Director-General's opening remarks at the media ... Thousands hit by Brazil outbreak of dengue edition.cnn.com, accessed 16 February 2020 Cambodia suffers worst dengue epidemic, ... Koh, B. K.; Ng, L. C.; Kita, Y.; Tang, C. S.; Ang, L. W.; Wong, K. Y.; James, L.; Goh, K. T. (2008). "The 2005 dengue epidemic ... Dengue fever in Indonesia - update 4 11 May 2004 www.who.int, accessed 16 February 2020 "Ebola virus disease" (Press release). ...
"Dengue and severe dengue". World Health Organization. 24 October 2019. "Dengue and severe dengue". World Health Organization. ... Singapore Government dengue site that describes the mosquito "Aedes". NCBI Taxonomy Browser. 7158. (Articles with short ... including dengue fever, yellow fever, the Zika virus, and chikungunya, which are transmitted by species in the subgenus ...
"Dengue and severe dengue". www.who.int. Retrieved 25 April 2022. Vainio J, Cutts F, eds. (1998). Yellow Fever. WHO Division of ... Death occurs in up to half of those who get severe disease. In 2013, yellow fever was estimated to have caused 130,000 severe ... About 15% of people infected with yellow fever progress to a severe form of the illness, and up to half of those will die, as ... Among those who develop jaundice, the fatality rate is 20 to 50%, while the overall fatality rate is about 3 to 7.5%. Severe ...
"Dengue and severe dengue". World Health Organization. Fact sheet N°117. March 2014. Archived from the original on 2016-09-02. ... Ranjit S, Kissoon N (January 2011). "Dengue hemorrhagic fever and shock syndromes". Pediatric Critical Care Medicine. 12 (1): ... "Consensus document on the epidemiology of severe acute respiratory syndrome (SARS)" (PDF). Department of Communicable Disease ...
"Severe Dengue Fever Outbreak in Taiwan". The American Journal of Tropical Medicine and Hygiene. 94 (1): 193-197. doi:10.4269/ ... Dengue fever is caused by the dengue virus, and is common in tropical and sub-tropical climates. Outbreaks occur from time to ... Hsu, Jason C.; Hsieh, Chin-Lin; Lu, Christine Y. (2017-01-01). "Trend and geographic analysis of the prevalence of dengue in ... Taiwan experienced consecutive outbreaks of dengue fever in both 2014 and 2015. CECC was activated on 2 February 2016. In ...
With more severe cases being referred to the capital, Dhaka's hospitals struggle to control the situation. 2019 dengue outbreak ... In Bangladesh's ongoing 2023 dengue epidemic season, the country has been witnessing the deadliest outbreak of dengue fever ... Dengue Press Release - 11/10/2023, Health Emergency Operation Centre and Control Room, MIS, Directorate General of Health ... "ডেঙ্গুতে এবছর মৃত্যু আগের সব হিসাব ছাড়াল" [Deaths for dengue this year crosses all past records]. Bdnews24.com (in Bengali). 3 ...
Gutiérrez, Luis A. (2015-03-11). "PAHO/WHO Data - Dengue and Severe Dengue , PAHO/WHO". Pan American Health Organization / ... There was also a low incidence of classic dengue with 2,340 cases reported in total. Damage to the water and sanitation ... The consequences of flooding in the Caribbean are severe because of the exponential increase in urbanization of floodplains, ... Vector-borne diseases brought on by flooding include dengue fever and malaria. In addition, displacement and eventual ...
"Severe Dengue Epidemic, Sri Lanka, 2017 - Volume 26, Number 4-April 2020 - Emerging Infectious Diseases journal - CDC". ... The dengue pandemic in Sri Lanka is part of the tropical disease dengue fever pandemic. Dengue fever is caused by Dengue virus ... From 1989 onward, dengue fever has become endemic in Sri Lanka. Dengue outbreaks started to emerge in Sri Lanka in the 1960s, ... In 1990 dengue cases rose 1,350 of 54 deaths.[clarification needed] In the early 1990s, annual dengue cases were reported as ...
No treatment for either dengue or severe dengue exists beyond palliative care. The symptoms are high fever and flu-like ... resulting in a potentially fatal disease called severe dengue. Dengue fever is caused by a flavivirus which is spread mostly by ... Treatment is with medication, which may have severe side effects. There are 50-100 million dengue virus infections annually. ... Dengue fever is usually not fatal, but infection with one of four serotypes can increase later susceptibility to other ...
Silva MM, Gil LH, Marques ET, Calzavara-Silva CE (Sep 2013). "Potential biomarkers for the clinical prognosis of severe dengue ... and patients who showed clinical symptoms associated with severe Dengue. The study suggests that this gene expression panel may ... is differentially expressed between patients who developed clinical symptoms associated with the mild disease type of Dengue ... serve as biomarkers of clinical prognosis in Dengue hemorrhagic fever. Further studies also indicate a role for PMSB9, in a ...
A fifth person dies from dengue. The patient was a 66-year-old Chinese male who had multi-organ failure from severe dengue ... Dengue fever outbreaks (worldwide) Ng, Jun Sen (11 February 2020). "Dengue cases at four-year high". today. the dengue outbreak ... In the 2013 dengue outbreak in Singapore, a significant rise in the number of dengue fever cases was reported in Singapore. The ... "Dengue cases down for 4th week in a row". TODAY. 29 July 2013. "Singapore's dengue cases reach a record 22,403, surpassing 2013 ...
"Bangladesh: Nearly 1,000 people die of dengue in severe outbreak". BBC News. 2023-09-28. Retrieved 2023-09-29. "Architect ... 28 September: 2023 dengue outbreak in Bangladesh: Nearly 1,000 people have died of dengue fever in Bangladesh in recent weeks, ... in the country's most severe outbreak of the disease so far. 2 January - Mubasshar Hussein, 80, architect, educationist, sports ...
"APEC Conference on Severe Dengue Prevention and Strategies for Reducing Disease Burden". www.cdc.gov.tw. Retrieved 2020-04-13. ...
Also more than 2,000 people died in Karachi, Pakistan in June 2015 due to a severe heat wave with temperatures as high as 49 °C ... There were outbreaks of diseases like malaria, dengue, and other skin diseases. Flood runoff can wash soil contaminants like ... Due to an increase in heavy rainfall events, floods are expected to become more severe in future when they do occur.: 1155 ... Around 20-30 minutes after a thunderstorm, there is an increased risk for people with pollen allergies to experience severe ...
Dengue fever is an infectious disease also carried by mosquitoes and caused by any of four related dengue viruses. It is also ... However, it would not have much impact on higher altitude headwaters where the effects of decreasing snowpack are more severe ... Health experts have known about dengue fever for more than 200 years. An epidemic in Hawaii in 2001 was a reminder that many ... Worldwide, 50-100 million cases of dengue infection occur each year. This includes 100-200 cases in the United States, mostly ...
Dengue fever is mostly characterized by high fever, headaches, joint pain, and rash. However, more severe instances can lead to ... However, ongoing clinical research is in the works to find specific anti-dengue drugs. Dengue fever occurs via aedes aegypti ... Halstead, Scott B. (June 1990). "Dengue and dengue hemorrhagic fever". Current Opinion in Infectious Diseases. 3 (3): 434-438. ... "Dengue and dengue haemorrhagic fever". The Lancet. 352 (9132): 971-977. doi:10.1016/S0140-6736(97)12483-7. ISSN 0140-6736. PMID ...
Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes? Professor Seneviratne is a member of ... Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes?". Transactions of the Royal Society ...
... in severe dengue virus infections". Journal of Medical Virology. 76 (4): 547-52. doi:10.1002/jmv.20397. PMID 15977234. S2CID ...
The year ended with a total of 35,315 dengue fever cases, including 54 instances of dengue haemorrhagic fever, a more severe ... In the 2020 dengue outbreak in Singapore, a record-breaking number of dengue fever cases was reported in Singapore. This was ... "Dengue Cases Expected To Exceed Last Year's 16,000 Cases Unless All Stakeholders Take Immediate Concerted Action Against Dengue ... "Dengue surveillance data, Jan - Mar 2020" (PDF). National Environment Agency. "Dengue surveillance data, Apr - Jun 2020" (PDF ...
Severe dengue can be fatal, but with good treatment, fewer than 1% of patients die from dengue. Work published in 2012 from ... Dengue viruses are a significant health risk globally. Severe cases of dengue often require hospitalization and can be life- ... Warning signs of severe dengue infection include vomiting blood, bleeding from the gums or nose, and stomach tenderness/pain. ... "Dengue". www.cdc.gov. 2020-07-16. Archived from the original on 2020-09-17. Retrieved 2020-09-22. Muslu H, Kurt O, Özbilgin A ( ...
... dengue fever and severe influenza between 1908 and 1909. In 1907 there were 191 enrolled infants at the school, but by 1911, ...
Mosquito bites are responsible for the transmission of dengue fever and malaria. Leech bite A natural consequence of a bite is ... If major blood vessels are damaged, severe blood loss can occur. Pathogen organisms can be introduced into the bite. Some of ... Many diseases such as malaria and dengue are transmitted by mosquitoes. Human bites are the third most frequent type of bite ...
Some of these diseases, such as malaria, yellow fever, and dengue fever, can have potentially severe health consequences. ... Much like the common cold CoVs, the potential for severe disease will likely be present in those who lack a protective immune ... It is considered likely that the virus will eventually become endemic and, like the common cold, cause less severe disease for ... There are 3-5 million severe cases annually, with up to 650,000 respiratory-related deaths globally each year. The 1889-1890 ...
... and a person who has a second dengue infection involving a different type from the first one can suffer a severe illness. . " " ... and is perhaps best known in cases of Dengue fever when a person who has previously been infected with one serotype of Dengue ... According to the WHO, of the 28 patients who had survived their infections, 19 illnesses were severe and 9 were mild. The WHO ... This not only suggests greater exposure among elderly men but also a possible greater biological susceptibility to more severe ...
Dengue virus group Dengue virus (DENV) Kedougou virus (KEDV) Japanese encephalitis virus group Cacipacore virus (CPCV) Koutango ... These may come into wide use to effectively prevent this severe disease in the huge populations of Asia-North, South and ... Henderson BR, Saeedi BJ, Campagnola G, Geiss BJ (2011). Jeang K (ed.). "Analysis of RNA binding by the Dengue virus NS5 RNA ... They were originally identified within the genome of Dengue virus and are found adjacent to each other within the 3'UTR. They ...
... like dengue, an antibody response to one infection can counterintuitively make the next infection more severe." Jon Cohen. "How ... The immune system's response to a few diseases, such as dengue, counterproductively worsens the next infection (antibody- ...
Dengue fever is a benign, acute febrile syndrome occurring in tropical regions. ... Dengue has been called the most important mosquito-transmitted viral disease in terms of morbidity and mortality. ... encoded search term (Severe Dengue Infection) and Severe Dengue Infection What to Read Next on Medscape ... Severe dengue infection diagnosis criteria include the following: [2, 15] * Severe plasma leakage leading to shock and/or fluid ...
... complicate the search for a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. ... A new study finds that people who have antibodies to the mosquito-borne Zika virus are more vulnerable to developing dengue ... more severe dengue infection. In addition, when a person had two sequential dengue infections, the type of dengue virus that ... one of the more severe of the four flavors, or serotypes, of dengue, and the first major outbreak of dengue since the Zika ...
... February 8, 2019. Article ... Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if ... Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus ... Results of the study, Dengue virus immunity increases Zika virus-induced damage during pregnancy, were published in the ...
Access Severe Dengue case definitions; uniform criteria used to define a disease for public health surveillance. ...
Treating a pregnant dengue-infected patient presents many unique challenges, especially regarding hemostasis, as seen in this ... Management of Severe Dengue Hemorrhagic Fever and Bleeding Complications in a Primigravida Patient. A Case Report. ... She tested positive for both immunoglobulin G and immunoglobulin M dengue serology indicating she had secondary dengue ... presented to our intensive care unit due to acute pulmonary edema secondary to massive plasma leakage caused by severe dengue. ...
About symptoms presented by dengue virus infection and how to treat at home and when to go to the emergency room. ... Severe dengue is a medical emergency.. Severe dengue. *About 1 in 20 people who get sick with dengue will develop severe dengue ... Symptoms of severe dengue. Warning signs of severe dengue Watch for signs and symptoms of severe dengue. Warning signs usually ... Severe dengue can result in shock, internal bleeding, and even death.. *If you have had dengue in the past, you are more likely ...
Lesions generally more severe in cerebral cortex. Vascular endothelium changes noted. No prominent perivascular infiltration (9 ...
Dengue fever, dengue hemorrhagic fever, and severe dengue. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM ...
Dengue virus infections §. Diphtheria. Ehrlichiosis and Anaplasmosis. Dengue. Dengue-like illness. Severe dengue. Anaplasma ...
Dengue. Dengue-like illness. Severe dengue. Current week. Previous 52 weeks Max †. Cum YTD 2022 †. Cum YTD 2021 †. Current week ...
Severe dengue progression beyond enhancement The immune response to dengue virus infection is a well-coordinated balancing act ... is associated with progression to severe disease. ...
The World Health Organization (WHO) is building a better future for people everywhere. Health lays the foundation for vibrant and productive communities, stronger economies, safer nations and a better world. Our work touches lives around the world every day - often in invisible ways. As the lead health authority within the United Nations (UN) system, we help ensure the safety of the air we breathe, the food we eat, the water we drink and the medicines and vaccines that treat and protect us. The Organization aims to provide every child, woman and man with the best chance to lead a healthier, longer life.
Dengue fever is a mosquito-borne infection that causes severe flu-like symptoms. It can be fatal. There is no cure, but there ... Symptoms range of dengue fever from mild to severe. Severe symptoms can indicate. dengue shock syndrome (DSS) and dengue ... Dengue and severe dengue. (2022).. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. ... Severe symptoms. Between 0.5% and 5% of cases. of dengue fever become severe. If this happens, it can be life threatening. ...
Pakistan facing severe dengue emergency: Sherry Rehman. September 25, 2022. September 25, 2022. by Covert ... Islamabad: There is at least a 50 per cent increase in dengue fever cases following recent rains in the country, especially in ... "Karachi is seeing an outbreak of dengue while 584,246 people in camps throughout the country, health crisis could wreak havoc ... Warning about worsening situation in Sindh due to outbreaks of water and vector-borne diseases including dengue and cholera, ...
Severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage while all ... Climate change and infectious diseases#Dengue fever "Dengue and severe dengue Fact sheet N°117". WHO. May 2015. Archived from ... The 1997 classification divided dengue into an undifferentiated fever, dengue fever, and dengue hemorrhagic fever. Dengue ... "Dengue and severe dengue". www.who.int. Retrieved 15 December 2019. Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, ...
ACIP analysis of the Dengvaxia Dengue Vaccine for persons 9-16 years of age with laboratory-confirmed previous dengue infection ... No dengue vaccination. Outcomes. Protection against virologically confirmed dengue, severe dengue, and hospitalization for ... severe dengue, and hospitalization among children ages 9-16 yrs with confirmed previous dengue infection, CYD-TDV Dengue ... vaccine and have not been previously infected with a dengue virus may be at risk of developing severe dengue if they get dengue ...
Dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, Aedes mosquitoes, DHF, DF, DSS ... Dengue can be life threatening. Severe dengue requires hospitalization.. About the Dengue Vaccine. *A dengue vaccine, Dengvaxia ... In children who have not already had dengue before, the dengue vaccine increases the risk of severe illness and hospitalization ... Dengue Vaccineplus icon*For Healthcare Providers: A Dengue Vaccine Can Protect Your Patientsplus icon*Vaccine Eligibility & ...
Dengue and Severe Dengue Fact Sheet. This web page contains key facts, information about the global burden of dengue, including ... More Trending Topic Dengue Resources. *Dengue and Severe Dengue Fact Sheet. *Dengue Virus: What You Need to Know ...
The cumulative number of dengue cases in the State is 2,788 out ... There was a considerable drop in the number of new dengue cases ... The cumulative number of dengue cases in the State is 2,788 out of which 2,505 patients have recovered. Out of the 21 cases ... Out of the 16 dengue patients who have died so far, 13 died in Dehradun district while three deaths were reported in Nainital ... There was a considerable drop in the number of new dengue cases reported in the State on Monday. The Health department reported ...
Severe dengue is of two types, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), both of which are life- ... Severe Dengue Complicated By Acute Pancreatitis. Author: Dr. Adnan Bashir Bhatti, Dr. Farhan Ali, Dr. Siddique Akbar Satti, ... The need of the hour is to know in depth the pathogenesis of acute pancreatitis in severe dengue, so that specific management ... A 16 year old female had presented with severe dengue with shock and acute pain in abdomen because of pancreatitis. The ...
Dengue Death Toll Tops 1000 21 hours ago. Obese women experience severe menopausal symptoms ...
Storms heading to Texoma on Wednesday, but how severe? Local News / 2 hours ago. .cls-3{fill:#fff;fill-rule:evenodd}. ... Dengue outbreak in Bangladesh sparks alarm after 364 people die this year and infections rise by: JULHAS ALAM, Associated Press ... Dengue causes flu-like symptoms that most people recover from, but also can rapidly lead to internal bleeding, organ failure ... In the first 10 days of August, more than 23,000 people were diagnosed with dengue, compared to 43,854 cases during all of July ...
Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria ... Malaria infection and severe disease risks in Africa * Feasibility study of a field survey to measure antimicrobial usage in ... Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam 2018 * Antimalarial drugs for treating and preventing ... Guidelines should not pool evidence from uncomplicated and severe COVID-19 * G6PD Variants and Haemolytic Sensitivity to ...
Results The range in which the proportion of the number of people infected with severe dengue is included with respect to the ... Conclusion A mathematical spatial-temporal self-organization was found in the proportion of severe dengue with respect to the ... the proportion of cases of severe dengue was calculated with respect to the total for each year. Probability spaces were ... Objective To establish a new predictive methodology to determine the proportion of severe dengue with respect to the annual ...
Sequential infections put people at greater risk for severe dengue. Although dengue in Timor-Leste is not unexpected, the ... In previous outbreaks between 2005 and 2012, two co-circulating serotypes, dengue virus 1 (DENV-1) and dengue virus 3 (DENV-3 ... There is no specific treatment for dengue. Early recognition of dengue virus infection and appropriate clinical management can ... 142 were severe dengue cases and 20 fatalities were reported (case fatality ratio 1.6%). The majority of the cases who ...
p>In the second infection of dengue by different serotypes than the previous, antibodies do not prevent cell entry of pathogens ... In the second infection of dengue by different serotypes than the previous, antibodies do not prevent cell entry of pathogens ... Moreover, sequential infections increase the risk of developing severe dengue. Severe dengue is a life-threatening complication ... ADE can lead to more severe forms of the disease, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). ...
  • Genetic studies with DENV-3 strains from progress to a life-threatening disease known as dengue Sri Lanka demonstrated that viruses isolated before and hemorrhagic fever (DHF). (cdc.gov)
  • In a small proportion of cases, the virus causes increased vascular permeability that leads to a bleeding diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). (medscape.com)
  • The WHO estimates that 50-100 million cases of dengue infection occur annually, with approximately 500,000 of those cases resulting in dengue hemorrhagic fever (DHF), with an estimated 22,000 deaths per year, mostly in children. (medscape.com)
  • The incidence of dengue hemorrhagic fever is increasing among the adult population living in endemic areas. (medscape.com)
  • Fever, thrombocytopenia, and hemoconcentration are the classical symptoms of dengue hemorrhagic fever observed in adult, pediatric, and obstetric populations. (medscape.com)
  • In conclusion, an important principle in the management of dengue hemorrhagic fever in pregnancy is to prioritize maternal well-being prior to addressing fetal issues. (medscape.com)
  • Dengue fever, dengue hemorrhagic fever, and severe dengue. (medlineplus.gov)
  • Severe symptoms can indicate dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF). (medicalnewstoday.com)
  • In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • Dengue is a mosquito borne viral hemorrhagic fever which is endemic in the tropical countries and adjacent subtropics. (journalcra.com)
  • Severe dengue is of two types, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), both of which are life-threatening. (journalcra.com)
  • ADE can lead to more severe forms of the disease, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). (onlinekhabar.com)
  • Dengue hemorrhagic fever is a severe and fatal complication of dengue. (answers.com)
  • Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
  • Gubler, D.J. (1987) Dengue and Dengue Hemorrhagic Fever in the Americas. (scirp.org)
  • Gubler, D.J. (1997) Dengue and Dengue Hemorrhagic Fever: Its History and Resurgence as a Global Public Health Problem. (scirp.org)
  • Gubler, D.J. (2001) The Global Pandemic of Dengue/Dengue Hemorrhagic Fever: Current Status and Prospects for the Future. (scirp.org)
  • Gubler, D.J. and Trent, D.W. (1994) Emergence of Epidemic Dengue/Dengue Hemorrhagic Fever as a Public Health Problem in the Americas. (scirp.org)
  • WHO (1997) Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. (scirp.org)
  • A more serious version of the disease, called dengue hemorrhagic fever, causes bleeding and can be deadly. (msdmanuals.com)
  • Dengue hemorrhagic fever is a much more severe type of dengue. (msdmanuals.com)
  • Go to the hospital right away if you have symptoms of dengue hemorrhagic fever. (msdmanuals.com)
  • Dengue fever is a benign, acute febrile syndrome occurring in tropical regions. (medscape.com)
  • Dengue fever is not contagious through person-to-person contact. (medscape.com)
  • Mild symptoms of dengue can be confused with other illnesses that cause fever, aches and pains, or a rash. (cdc.gov)
  • See a healthcare provider if you develop a fever or have symptoms of dengue. (cdc.gov)
  • Dengue fever, or breakbone fever, results from a viral infection carried by Aedes mosquitoes. (medicalnewstoday.com)
  • Four different viruses can cause dengue fever. (medicalnewstoday.com)
  • Symptoms range of dengue fever from mild to severe. (medicalnewstoday.com)
  • For most people, the best way to prevent dengue fever is to take steps to avoid mosquito bites. (medicalnewstoday.com)
  • There is no cure for dengue fever. (medicalnewstoday.com)
  • This article looks at the symptoms and causes of dengue fever and who is at risk. (medicalnewstoday.com)
  • Symptoms of dengue fever will depend on the severity of the disease. (medicalnewstoday.com)
  • Around 75% of people with dengue fever will not experience symptoms. (medicalnewstoday.com)
  • Between 0.5% and 5% of cases of dengue fever become severe. (medicalnewstoday.com)
  • Here are some images that may help identify dengue fever. (medicalnewstoday.com)
  • A person can have dengue fever more than once . (medicalnewstoday.com)
  • A person is at risk of dengue fever if they live or travel in an area where dengue occurs and mosquitoes that can carry it live. (medicalnewstoday.com)
  • The signs and symptoms of dengue fever are similar to some other diseases such as influenza and malaria . (medicalnewstoday.com)
  • Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. (wikipedia.org)
  • Paracetamol (acetaminophen) is recommended instead of nonsteroidal anti-inflammatory drugs (NSAIDs) for fever reduction and pain relief in dengue due to an increased risk of bleeding from NSAID use. (wikipedia.org)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • Therefore, travelers returning from endemic areas are unlikely to have dengue fever if symptoms start more than 14 days after arriving home. (wikipedia.org)
  • Children often experience symptoms similar to those of the common cold and gastroenteritis (vomiting and diarrhea) and have a greater risk of severe complications, though initial symptoms are generally mild but include high fever. (wikipedia.org)
  • The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. (wikipedia.org)
  • An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. (wikipedia.org)
  • Defervescence (the abatement of fever to body temperature below 38.0 ° C or 100.4 ° F) marks the beginning of the critical phase, which is when progression to severe dengue can occur and lasts 1 to 2 days. (cdc.gov)
  • The virus is primarily transmitted by Aedes Aegypti mosquitoes and should be suspected when 2 of the fol owing symptoms are accompanied by a high-grade fever of 40°C for 2-7 days: severe headache, retro-orbital pain, myalgia and arthralgia, vomiting, nausea, lymphadenopathy, or rash (2). (who.int)
  • Clinical presentation of infected patients is extensive and may differ from asymptomatic infection to alarming complications such as dengue haemorrhagic fever, dengue shock syndrome, marked bleeding, coagulopathy, encephalitis, and intracranial bleed (2). (who.int)
  • In Pakistan, dengue fever is a year-round, nationwide hazard with most cases being reported between September and December. (who.int)
  • cases of dengue fever in 2017, around 3200 in 2018, 24 547 cases in 2019, 3442 cases in 2020, and a total of 48 906 cases with 183 deaths countrywide in 2021 (3). (who.int)
  • In the medical literature, a large number of atypical presentations of dengue fever have been documented till now. (journalcra.com)
  • However, we are reporting a rare and deadly complication of dengue fever in the form of acute pancreatitis. (journalcra.com)
  • Dengue can cause a range of symptoms , from mild fever and headache to severe bleeding and shock. (onlinekhabar.com)
  • Severe dengue usually manifests after the fever subsides, and requires immediate medical attention and hospitalisation. (onlinekhabar.com)
  • Some also use non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin to relieve pain and fever, which can worsen the bleeding tendency in dengue patients. (onlinekhabar.com)
  • The common symptoms of dengue include high fever (40°C/104°F), severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands and rash. (onlinekhabar.com)
  • Late diagnosis and inadequate medical care can contribute to the progression of dengue to its severe forms, such as dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS). (hindustantimes.com)
  • It is an illness that affects infants, young children, and adults, with symptoms ranging from mild fever to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. (paho.org)
  • The infection may be asymptomatic, or it may present with symptoms ranging from a moderate fever to a disabling high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rashes. (paho.org)
  • The virus that causes dengue fever is transmitted by the bite of Aedes Aegypti mosquito, recognised by black and white markings on its legs. (hindustantimes.com)
  • People may also experience severe abdominal pain, persistent vomiting, rapid breathing, bleeding from gums or nose, fatigue or restlessness even after they recover from the fever. (hindustantimes.com)
  • Severe cases can lead to dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS), which can be life-threatening. (hindustantimes.com)
  • Unfortunately for the many millions of people diagnosed with sub-severe dengue fever each year, Khatri's painful symptoms are typical enough. (gavi.org)
  • Dengue fever is an infectious disease caused by dengue virus that comes from the bite of Aedes aegypti mosquito. (answers.com)
  • Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
  • A significant surge in dengue fever cases has gripped Bangladesh, the UN World Health Organization (WHO) reported on Friday, calling for efforts to control the mosquito vector population and minimize individual exposure such as using mosquito repellents and wearing long-sleeved clothes. (globalissues.org)
  • Severe dengue symptoms often come after the fever has gone away and may include severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums or nose, fatigue, restlessness, blood in vomit or stool, being very thirsty, pale and cold skin, and feeling weak. (globalissues.org)
  • How is Dengue Fever spread? (proprofs.com)
  • Dengue Fever is primarily spread through mosquito bites. (proprofs.com)
  • Which of the following is NOT a symptom of Dengue Fever? (proprofs.com)
  • Loss of hearing is not a symptom of Dengue Fever. (proprofs.com)
  • Dengue Fever is a viral infection transmitted by mosquitoes. (proprofs.com)
  • Common symptoms include high fever, severe headache, muscle and joint pains, and loss of appetite. (proprofs.com)
  • However, loss of hearing is not typically associated with Dengue Fever. (proprofs.com)
  • Breathlessness is not a symptom of Dengue Fever. (proprofs.com)
  • Common symptoms include high fever, severe headache, joint and muscle pain, and a rash. (proprofs.com)
  • It is important to seek medical attention if any of these symptoms occur, as severe cases of Dengue Fever can lead to complications. (proprofs.com)
  • High Fever is a symptom of Dengue Fever. (proprofs.com)
  • The most common symptom of Dengue Fever is a sudden onset of high fever, typically lasting for 2-7 days. (proprofs.com)
  • However, coughing up blood, hallucinations, and increased stress are not typically associated with Dengue Fever. (proprofs.com)
  • How many people were found to be infected with Dengue Fever in Singapore in the first 3 weeks of January 2009? (proprofs.com)
  • How can you prevent the spread of Dengue Fever? (proprofs.com)
  • Clearing stagnant water is an effective way to prevent the spread of Dengue Fever. (proprofs.com)
  • By getting rid of stagnant water, the mosquito population decreases, reducing the risk of Dengue Fever transmission. (proprofs.com)
  • It occurs in two forms: Dengue Fever and Dengue Haemorrhagic Fever (DHF). (apollohospitals.com)
  • Dengue Fever is a severe, flu-like illness. (apollohospitals.com)
  • Dengue Haemorrhagic Fever (DHF) is a more severe form of disease, which may cause death. (apollohospitals.com)
  • This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course. (fiocruz.br)
  • Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. (fiocruz.br)
  • Discussion: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. (fiocruz.br)
  • In some patients, endothelial cell and platelet dysfunction lead to life-threatening hemorrhagic dengue fever or dengue shock syndrome. (gabriel-network.org)
  • The proteomes of virion-enriched fractions purified from plasma pools of patients with dengue fever or severe dengue were compared. (gabriel-network.org)
  • Both dengue fever and severe dengue viral-enriched fractions contained identifiable viral envelope proteins and host cellular proteins. (gabriel-network.org)
  • Some host proteins were over- or under-represented in plasma from patients with severe dengue compared to patients with dengue fever. (gabriel-network.org)
  • ELISAs were used to validate differential expression of a selection of identified host proteins in individual plasma samples of patients with dengue fever compared to patients with severe dengue. (gabriel-network.org)
  • Dengue fever is a viral infectious disease. (css.ch)
  • One of the most prominent medicinal benefits of papaya leaf is its potential to treat certain symptoms associated with dengue fever . (healthline.com)
  • Dengue is a mosquito-borne virus that can be transmitted to humans and cause flu-like symptoms, such as fever, fatigue, headaches, nausea, vomiting, and skin rashes ( 1 ). (healthline.com)
  • Studies have found that papaya leaf extract can improve blood platelet levels in people with dengue fever. (healthline.com)
  • The mosquito-borne virus causes fever, severe headaches and extreme joint and muscle pain. (foxnews.com)
  • Guha-Sapir, D. and Schimmer, B. (2005) Dengue Fever: New Paradigms for a Changing Epidemiology. (scirp.org)
  • Bandyopadhyay, S., Lum, L.C. and Kroeger, A. (2006) Classifying Dengue: A Review of the Difficulties in Using the WHO Case Classification for Dengue Haemorrhagic Fever. (scirp.org)
  • Take dengue - sometimes known as "break-bone fever", which gives you some idea of its symptoms - which has exploded over the past few decades. (channelnewsasia.com)
  • Chikungunya , a viral infection that causes symptoms such as fever and severe joint pain. (medlineplus.gov)
  • In more severe cases, people may feel weak for several weeks, but it's rare to die from dengue fever. (msdmanuals.com)
  • [ 3 ] Secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for the development of DHF. (medscape.com)
  • Thrombocytopenia and hemoconcentration are consistent findings in dengue infection. (medscape.com)
  • There is no specific pharmacologic treatment for dengue infection. (medscape.com)
  • Patients with suspected dengue infection who are maintaining adequate hydration orally and have no warning signs/symptoms may be treated on an outpatient basis with appropriate anticipatory guidance and outpatient follow-up within 24 hours for reassessment. (medscape.com)
  • Dengue vaccine was approved by the FDA in 2019 for prevention of dengue disease caused by dengue virus serotypes 1, 2, 3, and 4 in individuals aged 9-16 years with laboratory-confirmed previous dengue infection who live in endemic areas. (medscape.com)
  • Its findings confirm earlier suspicions that some antibodies to the Zika virus, which usually serve to protect the body from infection, may actually interact with dengue viruses in ways that can make dengue infection worse. (sciencedaily.com)
  • The key thing that our study establishes is that prior Zika infection does significantly increase your risk of both symptomatic and more severe forms of dengue disease," said study first author Leah Katzelnick, who performed the research as postdoctoral scholar at the University of California, Berkeley's School of Public Health. (sciencedaily.com)
  • The first question was, 'How will prior dengue virus infection affect Zika? (sciencedaily.com)
  • Using data from the cohort, Harris published a 2019 study showing that prior dengue virus infection can grant a small amount of protection against Zika, and other studies now support this conclusion. (sciencedaily.com)
  • By mid-autumn, the researchers had enough evidence to prove that having a prior Zika infection made a person more likely to have a symptomatic dengue infection. (sciencedaily.com)
  • The research team led by Jean Lim, PhD, associate professor of microbiology and co-director of microbiology multidisciplinary training in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, transferred dengue virus-specific antibodies into mice prior to infection with Zika virus during pregnancy. (infectioncontroltoday.com)
  • Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy,' said Dr. Lim. (infectioncontroltoday.com)
  • She tested positive for both immunoglobulin G and immunoglobulin M dengue serology indicating she had secondary dengue infection, which placed her at risk for an exaggerated cytokine response as was evident clinically. (medscape.com)
  • The immune response to dengue virus infection is a well-coordinated balancing act. (nature.com)
  • New research shows that an imbalanced response - driven partially by the productive infection of antigen-presenting cells - is associated with progression to severe disease. (nature.com)
  • Subsequent infection with a different type increases the risk of severe complications. (wikipedia.org)
  • The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection. (cdc.gov)
  • In May 2019, Dengvaxia® was approved by the U.S. Food and Drug Administration (FDA) in the United States for use in children 9-16 years old living in an area with endemic dengue with laboratory confirmed prior dengue virus infection. (cdc.gov)
  • Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
  • To prevent dengue infection, travelers to dengue-endemic areas should protect themselves against mosquito bites by using EPA-registered insect repellent , wearing long-sleeved shirts and long pants, and taking other protective measures while traveling. (cdc.gov)
  • In 2019, the U.S. Food and Drug Administration approved Dengvaxia for use in children 9-16 years old with laboratory evidence of a previous dengue infection and living in areas where dengue is common. (cdc.gov)
  • Children 9-16 years old with laboratory-confirmed previous dengue infection and living in areas where dengue occurs frequently. (cdc.gov)
  • Your child must test positive for a previous dengue infection before being vaccinated. (cdc.gov)
  • Therefore, to reduce the risk of vaccinating children who have never had dengue, a blood test can check for a previous dengue infection. (cdc.gov)
  • Dose 1 can be given after confirming that your child had a prior dengue infection. (cdc.gov)
  • Why second infection from dengue is more severe than the first infection? (onlinekhabar.com)
  • Dengue is a viral infection that spreads from mosquitoes to people. (onlinekhabar.com)
  • Severe dengue is a life-threatening complication that occurs when the immune system overreacts to the second or subsequent infection by a different serotype. (onlinekhabar.com)
  • But in the second infection of dengue by different serotypes than the previous, antibodies do not prevent cell entry of pathogens but rather increase the ability of the virus to enter cells and cause worsening disease through a mechanism called ADE. (onlinekhabar.com)
  • Dengue is the most common viral infection that is caused due to mosquito bites. (hindustantimes.com)
  • Co-circulation of multiple strains can lead to more severe cases due to the phenomenon known as antibody-dependent enhancement (ADE), where exposure to one strain increases the risk of severe disease upon subsequent infection with another strain. (hindustantimes.com)
  • In some cases, a history of dengue infection can weaken the immune system's response, making individuals more susceptible to severe forms of the virus upon subsequent infections. (hindustantimes.com)
  • By avoiding the production of antibodies, something vaccines ordinarily induce, the immunization sidesteps the problem of antibody-dependent enhancement, which can amplify infection by a similar virus and is known to occur with dengue and Zika. (the-scientist.com)
  • Indeed, a past infection with Zika increases the severity of a subsequent infection with dengue, and even vaccines against certain dengue serotypes-there are four in all-can worsen infections with others. (the-scientist.com)
  • Following infection with one serotype, subsequent infection with a different serotype increases a person's risk of severe dengue and death. (paho.org)
  • Compared to 26 dengue cases in the entire month of August, 27 people have contracted the infection in just 11 days of September, as per health authorities in Chandigarh. (hindustantimes.com)
  • The infection can progress from mild to severe. (hindustantimes.com)
  • After the confirmation of dengue infection, my platelet count decreased to 82,000," Khatri recalls. (gavi.org)
  • The increase in temperature is the main reason for the spread of dengue infection in the mountains. (gavi.org)
  • A literature search for studies reporting risk factors of severe dengue among individuals with dengue virus infection was conducted in PubMed, Scopus and Web of Science database from inception to December 31, 2020. (biomedcentral.com)
  • Our meta-analysis identified children, secondary infection, diabetes and renal disease(s) as important predictors of severe dengue. (biomedcentral.com)
  • Dengue is an arboviral infection caused by a dengue virus (DENV) belonging to the Flaviviridae family. (biomedcentral.com)
  • Only adults aged 9-45 years living in an area of ≥ 70% dengue prevalence, and whose serostatus is positive for past dengue infection are recommended for immunization [ 6 ]. (biomedcentral.com)
  • Dengue infection is endemic in many countries along the tropical and subtropical belt, with more than 100 million cases and 24,000 deaths annually worldwide. (annals.edu.sg)
  • Hepatic dysfunction is common in dengue infection, and is attributed to a direct viral effect on liver cells or as a consequence of dysregulated host immune responses against the virus. (annals.edu.sg)
  • Clinical diagnosis of Dengue is conducted by laboratory testing on human serum and plasma tested for DENV SubT and dengue NS-1 (DENG NS-1), dengue IgG and IgM to confirm the presence of infection. (answers.com)
  • Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
  • Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
  • Dengue, a viral infection that transmits through mosquito bites, has long plagued tropical and sub-tropical regions. (globalissues.org)
  • It can only be given to kids ages 9 to 16 who have had prior dengue infection. (npr.org)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • Dengue virus infection is more and more acknowledged as one of the world's major escalating problems. (scirp.org)
  • According to the World Health Organization 5 , almost two million people in the Americas suffered from dengue virus infection in 2019, and more recent data showed that four billion people suffer from dengue and related viruses such as Zika and Chikungunya in 128 countries worldwide 6 . (nature.com)
  • Is dengue and malaria co-infection more severe than single infections? (bvsalud.org)
  • Doctors suspect dengue based on your symptoms and if you've been in an area where mosquitoes carry the infection. (msdmanuals.com)
  • Getting sick with the mosquito-borne Zika virus makes people more vulnerable to developing dengue disease later on, and to suffering from more severe symptoms when they do get sick from dengue, finds a new study published online today (Thursday, Aug. 27) in the journal Science . (sciencedaily.com)
  • Dengue disease is caused by not one but four closely related types of flaviviruses, each of which can strike with a slightly different set of symptoms and severity. (sciencedaily.com)
  • For people who get sick with dengue, symptoms can be mild or severe. (cdc.gov)
  • Symptoms of dengue typically last 2-7 days. (cdc.gov)
  • Treat the symptoms of dengue and see your healthcare provider. (cdc.gov)
  • Symptoms of dengue can become severe within a few hours. (cdc.gov)
  • Watch for signs and symptoms of severe dengue. (cdc.gov)
  • Anyone with severe symptoms needs immediate medical attention. (medicalnewstoday.com)
  • Severe signs and symptoms can indicate DSS or DHF. (medicalnewstoday.com)
  • Treatment for dengue involves managing the symptoms. (medicalnewstoday.com)
  • Patients with symptoms consistent with dengue can be tested with nucleic acid amplification tests (NAAT) AND IgM antibody tests within 7 days of symptom onset. (cdc.gov)
  • Dengue causes flu-like symptoms that most people recover from, but also can rapidly lead to internal bleeding, organ failure and even death. (texomashomepage.com)
  • Many people do not recognise the symptoms of dengue and delay seeking care. (onlinekhabar.com)
  • Therefore, it is important to educate people about the signs and symptoms of dengue and advise them to use paracetamol instead of NSAIDs. (onlinekhabar.com)
  • The diagnosis of dengue is based on clinical symptoms and laboratory tests. (onlinekhabar.com)
  • While dengue symptoms continue to be mild in most people, in many others it can be fatal. (hindustantimes.com)
  • Dengue symptoms can range from mild to severe depending on the strain and how the disease is being managed. (hindustantimes.com)
  • After being bitten by a mosquito carrying the virus, the incubation period ranges from three to 15 (usually five to eight) days before the signs and symptoms of dengue appear. (answers.com)
  • Most people with dengue have mild or no symptoms and get better within two weeks. (globalissues.org)
  • People with these severe symptoms should seek medical care right away. (globalissues.org)
  • Other symptoms may include severe headache, joint and muscle pain, rash, and mild bleeding. (proprofs.com)
  • Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. (fiocruz.br)
  • While there's currently no cure for dengue, several treatments are available for managing its symptoms - one of which is papaya leaf. (healthline.com)
  • What are the most commonly associated symptoms that could be associated with the onset of Dengue ? (ndtv.com)
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
  • Dengue is a disease spread by mosquitoes through bites. (cdc.gov)
  • These mosquitoes thrive in urban and semi-urban environments and are responsible for transmitting the dengue virus to humans. (hindustantimes.com)
  • Dengue is primarily transmitted by Aedes mosquitoes, especially Aedes aegypti. (hindustantimes.com)
  • Viruses of the flavivirus family, such as Zika and dengue, both transmitted to humans via the bites of infected mosquitoes, are particularly adept at this antibody exploitation. (the-scientist.com)
  • Dengue, which is spread by Aedes mosquitoes, has traditionally been considered a bug of lower-lying and tropical climates. (gavi.org)
  • Dr Chuman Lal Das, Director of the EDCD, says, "Diseases that occur in low-altitude areas like dengue have now started to be found in hilly and mountainous districts as the habitat of mosquitoes has shifted to higher altitudes. (gavi.org)
  • When mosquitoes make a home in the mountains, dengue isn't the only threat they bring with them. (gavi.org)
  • It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
  • Aedes aegypti mosquitoes are one of primary vectors for dengue. (globalissues.org)
  • Doctors state that the breeding of dengue mosquitoes depends upon humidity and temperature. (ndtv.com)
  • In a WHO press conference at the start of April about the worrying dengue and chikungunya (a related virus spread by the same mosquitoes) epidemics there, Raman Velyayudhan, head of the WHO global programme on the control of neglected tropical diseases, said that trend could continue around the world this year. (channelnewsasia.com)
  • The study, which drew on data from two cohorts of Nicaraguan children who lived through a Zika epidemic in 2016 and a dengue epidemic in 2019, is the first to investigate the impacts of Zika immunity on dengue disease in humans. (sciencedaily.com)
  • In 2019, the Food and Drug Administration (FDA) approved a vaccine for children ages 9-16 years who have had dengue in the past and live in areas where dengue is common. (medicalnewstoday.com)
  • In May 2019 , the FDA approved the first dengue vaccine. (medicalnewstoday.com)
  • This is the largest dengue outbreak in Nepal's history, surpassing the previous record of 18,000 cases and six deaths in 2019. (onlinekhabar.com)
  • Dengue incidence has increased in the Americas over the past four decades, from 1.5 million cumulative cases in the 1980s to 16,2 million in the decade 2010-2019. (paho.org)
  • In 2019, 17,992 dengue cases were reported in 68 districts. (gavi.org)
  • The incidence of dengue has surged dramatically with an eightfold increase over the last two decades, from 505 430 cases in 2000 to over 2.4 million in 2010, and 4.2 million in 2019 [ 3 ]. (biomedcentral.com)
  • A vaccine to prevent dengue (CYD-TDV, Dengvaxia®) is licensed and available in 20 countries for people ages 9-45 years old. (cdc.gov)
  • It's a vaccine to prevent dengue. (npr.org)
  • How can I prevent dengue? (msdmanuals.com)
  • In 20-30% of DHF cases, the patient develops shock, known as the dengue shock syndrome (DSS). (medscape.com)
  • BACKGROUND: Dengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. (ox.ac.uk)
  • 35,000) living in dengue-endemic areas. (medscape.com)
  • The approval of QDENGA is based on results through three years after vaccination from the ongoing Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial that enrolled over 20,000 healthy children and adolescents ages four to 16 years living in dengue-endemic areas in Asia and Latin America. (newswire.co.kr)
  • particularly interesting because before 1989 all 4 sero- types were present and many repeat infections occurred, Dengue viruses (DENVs) are mosquito-borne fl avivi- but few cases of DHF were documented ( 8 , 9 ). (cdc.gov)
  • Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
  • DHAKA,Bangladesh (AP) - Bangladesh is struggling to deal with higher casualties and infections from dengue this year, with officials warning that the death toll this month could break records. (texomashomepage.com)
  • Moreover, sequential infections increase the risk of developing severe dengue. (onlinekhabar.com)
  • The severity of dengue virus infections is influenced by multiple factors, with global warming playing a significant role in creating conducive conditions for mosquito breeding, viral replication, and altered transmission dynamics. (hindustantimes.com)
  • The severity of dengue virus infections can be influenced by a variety of factors, and global warming is indeed playing a role in exacerbating some of these factors," says Dr Pasha. (hindustantimes.com)
  • A total of 76 dengue infections have been reported in Chandigarh so far this year. (hindustantimes.com)
  • Background: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. (fiocruz.br)
  • Furthermore, all 4 serotypes of new clades of DENV-3 in 1989 and 2000 coincided with of DENV can cause DHF, but within each serotype some abrupt increases in the number of reported dengue cases, genotypes or clades within genotypes are linked to severe implicating this serotype in severe epidemics. (cdc.gov)
  • The two arrived at the very beginning of what would become a massive epidemic of dengue virus Type 2, one of the more severe of the four flavors, or serotypes, of dengue, and the first major outbreak of dengue since the Zika epidemic in 2016. (sciencedaily.com)
  • There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
  • The 4 dengue serotypes are serologically and genetically distinct, although they share several of their structural antigens. (cdc.gov)
  • One of the reasons why Nepal faces such a large number of dengue cases each year is the presence of all four serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, DENV-4) in the country. (onlinekhabar.com)
  • The four dengue serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) circulate throughout the Americas, and in some countries simultaneously. (paho.org)
  • It is transmitted by the bite of a mosquito infected with one of the four serotypes of dengue virus. (paho.org)
  • This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
  • While there has been no definitive association of the distinct DENV types with clinical course of disease, there are reports suggesting that DENV-2 and DENV-3 cause severe disease more frequently than the other serotypes and that DENV-4 causes a milder illness [ 23 , 24 ]. (hindawi.com)
  • QDENGA® (TAK-003) is a dengue vaccine that is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four dengue virus serotypes and is designed to protect against any of these serotypes. (newswire.co.kr)
  • In the last 15 years, specific regions of Pakistan have seen 10 times increase in the reported cases of dengue (4). (who.int)
  • The cases of dengue and chikungunya are expected to witness a surge in Europe too due to climate change European Union officials said. (hindustantimes.com)
  • But Rawal has been alarmed to see that this year, Mugu has recorded 12 cases of dengue - an unprecedented surge for this dilutely populated, famously isolated district. (gavi.org)
  • Persons not previously infected are at an increased risk of severe dengue disease when vaccinated and subsequently infected with dengue virus. (medscape.com)
  • Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report. (infectioncontroltoday.com)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • There is no specific medicine to treat dengue. (cdc.gov)
  • Infected people are overwhelming hospitals across the country, but some doctors and nurses are not sufficiently experienced, or trained, in how to treat dengue cases, experts say. (texomashomepage.com)
  • How do doctors treat dengue? (msdmanuals.com)
  • In the Americas, Aedes aegypti is the mosquito vector that is the main source of dengue transmission. (paho.org)
  • Dengue is a flu-like viral disease that is spread by the bite of an infected mosquito (Aedes mosquito). (answers.com)
  • Dengue is a viral disease it is transmitted by the infective bite of the Aedes Aegypti mosquito. (apollohospitals.com)
  • We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)
  • Getting sick with one type of dengue virus can increase the likelihood that a person will develop a second, more severe illness when infected with a separate type of dengue virus. (sciencedaily.com)
  • Others have more severe illness (5%), and in a small proportion it is life-threatening. (wikipedia.org)
  • Clinical disease varies from a mild, undifferentiated febrile illness to severe disease with shock, hemorrhage and/or severe organ impairment such as hepatitis and encephalitis. (cdc.gov)
  • Because most dengue cases reported in the continental United States occur in travelers, CDC is advising clinicians to consider dengue in patients with a febrile illness who have traveled to dengue-endemic areas in the 2 weeks before symptom onset. (cdc.gov)
  • Dengue is usually a mild illness. (cdc.gov)
  • In children who have not already had dengue before, the dengue vaccine increases the risk of severe illness and hospitalization if the child gets dengue after vaccination. (cdc.gov)
  • The illness can evolve to severe dengue, characterized by shock, respiratory distress, severe bleeding, and/or serious organ impairment. (paho.org)
  • BARNABY LO: Manufacturer Sanofi warned that the vaccine could trigger severe illness. (npr.org)
  • Method/Design: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. (fiocruz.br)
  • In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for "Integrated Management of Childhood Illness" used in dengue-endemic countries. (fiocruz.br)
  • QDENGA demonstrated continued overall protection against dengue illness and hospitalization three years after vaccination, regardless of an individual's previous dengue exposure. (newswire.co.kr)
  • Patients were randomized 2:1 to receive either the vaccine or saline placebo and monitored for symptomatic virologically confirmed dengue (VCD) starting at day 0. (medscape.com)
  • Protection against virologically confirmed dengue, severe dengue, and hospitalization for dengue. (cdc.gov)
  • Zika virus outbreaks were first found to be associated with birth defects including microcephaly, in which the baby is born with an abnormally small head and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic. (infectioncontroltoday.com)
  • The Centers for Disease Control and Prevention (CDC) is monitoring ongoing dengue outbreaks occurring in several regions around the world. (cdc.gov)
  • The increase in dengue incidence has been associated with explosive outbreaks and geographical expansion to new areas [ 3 ]. (biomedcentral.com)
  • With nations in South America battling some of the worst outbreaks of mosquito-borne disease in decades, the case of a British woman who caught dengue while on holiday in France last summer has sparked warnings about similar outbreaks in countries where insect-carried pestilence hasn't previously been endemic. (channelnewsasia.com)
  • Nowadays, about 140 countries deal with outbreaks of dengue regularly. (channelnewsasia.com)
  • And those outbreaks are getting larger and more severe. (channelnewsasia.com)
  • One such project is E-Dengue in Vietnam, designed to help health systems prepare for dengue outbreaks up to two months in advance by collating local data. (channelnewsasia.com)
  • Our team liaises with experts at CDC to produce content and trainings that cover a host of emergency preparedness and response topics, such as influenza, severe weather and natural disasters, and infectious disease outbreaks. (medscape.com)
  • 1997, most reported dengue cases were in children. (cdc.gov)
  • In the wake of these calamitous floods, reported dengue cases continued to increase throughout the country, including in Karachi where the public blames the government for the city's poor sanitary conditions and for not carrying out timely fumigation campaigns (7). (who.int)
  • Where the mosquito is, the virus is likely to follow: Sudan has reported dengue cases in the capital city for the first time, and France saw a chain of locally transmitted cases last summer. (channelnewsasia.com)
  • Dengue has emerged in many after emergence of DHF belonged to 2 distinct clades regions of the world and the number of cases and the range (DENV-3, genotype IIIA and IIIB, respectively), indicat- of the virus continue to increase every year ( 1 ). (cdc.gov)
  • It is caused by the dengue virus (DENV) that has four strains, namely DENV-1, DENV-2, DENV-3, and DENV-4. (hindustantimes.com)
  • Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
  • Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
  • There is no specific treatment for dengue, and prevention depends on reducing mosquito breeding and avoiding mosquito bites. (onlinekhabar.com)
  • While there is currently no specific treatment for dengue, early detection and appropriate healthcare for case management can significantly reduce mortality. (globalissues.org)
  • This web page contains key facts, information about the global burden of dengue, including transmission, characteristics, treatment, immunization and prevention and control. (thecompassforsbc.org)
  • The WHO estimates that Asia represents around 70% of the global burden of dengue, posing significant health and economic hazards to the South-East Asia Region (2). (who.int)
  • Vaccination will offer health care providers in Indonesia a welcomed advancement in dengue prevention, along with vector control, allowing us to reduce the burden of dengue and protect the broader population. (newswire.co.kr)
  • Sources have informed that apart from dengue, 66 cases of chikungunya and 45 cases of malaria have been reported in Chandigarh. (ndtv.com)
  • Warmer, wetter conditions mean tropical diseases like dengue and chikungunya are spreading, says Lara Williams for Bloomberg Opinion. (channelnewsasia.com)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • Emergence factor for severe disease ( 3 , 4 ). (cdc.gov)
  • Dengue has been called the most important mosquito-transmitted viral disease in terms of morbidity and mortality. (medscape.com)
  • The vaccine was approximately 76% effective in preventing symptomatic VCD disease among patients aged 9-16 years who were seropositive for dengue at baseline. (medscape.com)
  • A new study finds that people who have antibodies to the mosquito-borne Zika virus are more vulnerable to developing dengue disease. (sciencedaily.com)
  • That finding raises the questions: Could a vaccine only targeted at Zika actually put people at increased risk of more severe dengue disease? (sciencedaily.com)
  • However, after a person has been infected with two types of dengue viruses, they usually gain some degree of immune protection against future dengue disease severity. (sciencedaily.com)
  • Since 2004, Harris and her colleagues in Nicaragua have monitored a cohort of approximately 3,800 children living in Managua, the country's capital, tracking any signs of dengue disease and collecting annual blood samples to test for the virus and its antibodies. (sciencedaily.com)
  • But the inverse question, whether Zika antibodies protect against future dengue disease, or potentially enhance it, remained a mystery. (sciencedaily.com)
  • However, in about 5% of cases, it can progress to severe disease with associated shock, severe bleeding, or organ impairment. (cdc.gov)
  • Dengue is a nationally notifiable disease in the United States. (cdc.gov)
  • Management of hospitalized dengue patients requires frequent monitoring of vital signs and hematocrit levels to determine disease progression and appropriate response to fluid replacement therapy. (cdc.gov)
  • Dengue is caused by positive, single-stranded RNA viruses of the Flaviviridae family, and it is the most rapidly spreading arboviral disease. (who.int)
  • Another factor that contributes to the high incidence of dengue in Nepal is the lack of awareness and knowledge about the disease among the public and health workers. (onlinekhabar.com)
  • The researchers of a study found that global warming could be possibly changing the disease dynamics of dengue. (hindustantimes.com)
  • The disease can evolve into severe dengue, characterized by shock, shortness of breath, severe bleeding and / or complications in the organs. (paho.org)
  • PAHO/WHO provides advice and technical support for dengue prevention and control based on a regional strategy adopted by PAHO / WHO member States in 2016, called the " Strategy for arboviral disease prevention and control " (CD55.R6). (paho.org)
  • Classically a disease of lower-lying areas, dengue cases have this year surged in the hill zones of the Himalayan state. (gavi.org)
  • Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
  • Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. (fiocruz.br)
  • Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. (fiocruz.br)
  • We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. (fiocruz.br)
  • Background: Dengue is the most widespread mosquito-borne viral disease of public health concern. (gabriel-network.org)
  • OSAKA, JAPAN & CAMBRIDGE, MASS.--( Business Wire / Korea Newswire ) August 23, 2022 -- Takeda (TSE:4502/NYSE:TAK) today announced the company's dengue vaccine, QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003), was approved by the Indonesia National Agency for Drug and Food Control, Badan Pengawas Obat dan Makanan (BPOM), for the prevention of dengue disease caused by any serotype in individuals six years to 45 years of age. (newswire.co.kr)
  • Dengue is a mosquito-borne viral disease that poses a significant global public health threat, with prevalence in over 125 countries. (newswire.co.kr)
  • 2] In recent years, Indonesia has experienced almost half of the dengue disease burden within Southeast Asia and continues to suffer from one of the highest burdens of dengue in the world. (newswire.co.kr)
  • As a doctor, I have seen firsthand the burden dengue disease places on the patients and communities I serve in Indonesia. (newswire.co.kr)
  • There is an ongoing fear of an outbreak and contracting the disease, experiencing the physical setbacks dengue can cause as well as the potential financial impacts," said Dr. Anggraini Alam, Sp.A(K), pediatric infectious disease consultant. (newswire.co.kr)
  • In Indonesia, QDENGA is indicated for the prevention of dengue disease caused by any dengue virus serotype in individuals six years to 45 years of age and should be administered subcutaneously as a 0.5 mL dose at a two-dose (0 and 3 months) schedule pursuant to approved dosing regimen. (newswire.co.kr)
  • Dr Gaurav Aggarwal, anti-malaria officer, UT health department, told HT that though dengue cases are recorded throughout the year, peak season of the vector-borne disease is from September to November. (ndtv.com)
  • Dengue is a mosquito-borne viral disease caused by one of the many closely related dengue viruses. (ndtv.com)
  • Dengue disease presents highly complex pathophysiological, economic and ecologic problems. (ndtv.com)
  • This phenomenon, known as antibody-dependent enhancement (ADE), occurs when a person who has had dengue before is infected with a different dengue virus serotype. (onlinekhabar.com)
  • Thus, the recent heavy flooding, fol owed by an enormous spike in dengue cases, has caused serious calamity in the country. (who.int)
  • However, this year, Nepal has also witnessed a spike in dengue cases in October, especially in Kathmandu valley. (onlinekhabar.com)
  • It mainly affects children younger than 10 in areas where dengue is common. (msdmanuals.com)
  • The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
  • The higher incidence of dengue is taking place in the context of an unusual episodic amount of rainfall, combined with high temperatures and high humidity, which have resulted in an increased mosquito population throughout Bangladesh," WHO said . (globalissues.org)
  • The compensatory reserve index predicts recurrent shock in patients with severe dengue. (ox.ac.uk)
  • It is approved only in individuals previously infected by any dengue virus serotype or in whom this information is unknown. (medscape.com)
  • the main vector of dengue, has proved highly difficult to control, and continues to expand its geographic range. (cdc.gov)
  • Efforts to mitigate the impact of dengue and other vector-borne diseases should include addressing the climate change-related factors that contribute to their spread," says Dr. Ather Pasha - Consultant, General Medicine, CARE Hospitals, Banjara Hills, Hyderabad. (hindustantimes.com)
  • is the vector mosquito for dengue and is widely distributed in the Americas. (paho.org)
  • Only Canada and continental Chile are free from dengue and its vector. (paho.org)
  • In mountainous countries including Nepal, not only dengue but also malaria, Japanese encephalitis and other vector-borne diseases have been observed in high altitudes," says Dr Meghnath Dhimal, chief of the NHRC's research section. (gavi.org)
  • The mosquito becomes a vector after it has bitten an dengue infected carrier - usually another Human. (answers.com)
  • Severe dengue requires hospitalization. (cdc.gov)
  • In many Asian countries, severe dengue is the leading cause of hospitalization among children and the case fatality rate (CFR) is about 5% on average [ 5 ]. (biomedcentral.com)
  • Dengue can affect anyone living in or traveling to endemic areas - regardless of age, health and socio-economic circumstances," said Gary Dubin, president of Takeda's Vaccine Business Unit. (newswire.co.kr)
  • When Zika first emerged in Latin America in late 2015, many speculated whether the flavivirus, a close cousin to the dengue viruses, might interact with the dengue viruses in a similar way. (sciencedaily.com)
  • 1 in 4: About one in four people infected with dengue will get sick. (cdc.gov)
  • In 2022, Pakistan experienced the most severe flooding in recent years, triggered by the unusual torrential monsoon rains. (who.int)
  • As of 15 September 2022, an estimated 3830 dengue cases had been reported in Sindh and at least 9 lives had succumbed to the virus (5). (who.int)
  • In 2022, 62,382 people were infected and 281 people died of dengue, according to government figures. (texomashomepage.com)
  • Mosquito fogging is done to prevent a dengue outbreak in Kathmandu, on August 28, 2022. (onlinekhabar.com)
  • 3,4] In the first half of 2022 alone, Indonesia reported over 63,000 dengue cases and nearly 600 deaths spread across 455 cities in 34 provinces. (newswire.co.kr)
  • The need of the hour is to know in depth the pathogenesis of acute pancreatitis in severe dengue, so that specific management strategies can be devised for this critical complication. (journalcra.com)
  • The pathogenesis of severe dengue has not been fully elucidated, and the role of host proteins associated with viral particles has received little exploration. (gabriel-network.org)
  • Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
  • Dengue prevention and control must be intersectoral and involve the family and the community. (paho.org)
  • Dung Phung, the lead scientist on the project, said that currently dengue prevention and control is mostly reactive, limiting the effectiveness of measures to combat its spread. (channelnewsasia.com)
  • The majority of those were excluded as describing different live attenuated dengue vaccines or not including primary trial data. (cdc.gov)
  • The US Advisory Committee on Immunization Practices (ACIP) Dengue Vaccine Work Group reviewed Dengvaxia ® safety and efficacy data in a systematic literature review in 2018. (cdc.gov)
  • Results of the study, 'Dengue virus immunity increases Zika virus-induced damage during pregnancy,' were published in the February issue of Immunity, a journal published by Cell Press. (infectioncontroltoday.com)
  • Historic data reveal that increases in dengue cases significantly correlate with the amount of rainfal (6). (who.int)
  • Dengue cases tend to surge during the rainy season (June-September) when the mosquito population increases due to stagnant water and poor sanitation. (onlinekhabar.com)
  • The epidemiology of dengue in Sri Lanka is gence of severe dengue epidemics in Sri Lanka. (cdc.gov)
  • A man attends to his wife who is being treated for dengue at Mugda Medical College and Hospital in Dhaka, Bangladesh, Thursday, Aug. 10, 2023. (texomashomepage.com)
  • Dengue primarily prevails in tropical and subtropical regions, in both urban and suburban areas. (who.int)
  • Dengue is prevalent in most tropical and subtropical countries. (scirp.org)
  • The harms considered critical outcomes were serious adverse events, hospitalizations, severe dengue and deaths. (cdc.gov)
  • Out of the 16 dengue patients who have died so far, 13 died in Dehradun district while three deaths were reported in Nainital district. (dailypioneer.com)
  • According to the World Health Organization (WHO ), Nepal has reported over 42,000 confirmed cases and 51 confirmed deaths due to dengue this year, affecting all seven provinces and 77 districts. (onlinekhabar.com)
  • There were 37,692 severe cases and 1,280 deaths in the hemisphere. (paho.org)
  • Due to the challenges associated with the need to collect information on the burden and seroprevalence profiles of the local population, and the recent reports of vaccine-related severe dengue and deaths, the use of the dengue vaccines is not widespread [ 9 ]. (biomedcentral.com)
  • Military studies have shown that immediate control of severe bleeding significantly decreased preventable deaths on the battlefield. (health.mil)
  • There is no specific treatment and the dengue vaccine [CYD-TDV (Dengvaxia ® )] is licensed only in 20 countries [ 6 ]. (biomedcentral.com)
  • MARA CEPEDA: Suspends the sale of the controversial Dengvaxia dengue vaccine for a year. (npr.org)
  • because everyone in Latin America, to some degree or another, is eventually dengue immune and has dengue antibodies," said study senior author Eva Harris, a professor of infectious diseases and vaccinology at UC Berkeley. (sciencedaily.com)
  • Changes in climate, such as changes in rainfal patterns, flooding, catastrophic storms, severe fires, extreme precipitations, and intense droughts are exacerbating human pathogenic diseases and making the distribution of microbial species to surge drastical y (1). (who.int)
  • The floods swept away entire vil ages and destroyed rural communities, displacing around 33 mil ion people and exposing them to increased risks of drowning, malnutrition and water-borne diseases, especial y dengue (5). (who.int)
  • The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. (ndtv.com)