A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.
A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.
A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed & Black's Veterinary Dictionary, 17th ed)
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.
A characteristic symptom complex.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The segregation of patients with communicable or other diseases for a specified time. Isolation may be strict, in which movement and social contacts are limited; modified, where an effort to control specified aspects of care is made in order to prevent cross infection; or reverse, where the patient is secluded in a controlled or germ-free environment in order to protect him or her from cross infection.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Glycoproteins found on the membrane or surface of cells.
Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Proteins found in any species of virus.
Identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection. Contact tracing is a generally accepted method for the control of sexually transmitted diseases.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
A country spanning from central Asia to the Pacific Ocean.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The temporal sequence of events that have occurred.
Ribonucleic acid that makes up the genetic material of viruses.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The individuals employed by the hospital.
Established cell cultures that have the potential to propagate indefinitely.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
The lone species in the genus Nyctereutes, family CANIDAE. It is found in the woodland zone from southeastern Siberia to Vietnam and on the main islands of Japan.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A family of viruses, of the order NIDOVIRALES, containing spherical virions. In contrast to CORONAVIRIDAE, no protruding spikes are obvious on the surface.
Aspects of health and disease related to travel.
Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.
Programs of surveillance designed to prevent the transmission of disease by any means from person to person or from animal to man.
Substances elaborated by viruses that have antigenic activity.
A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Any infection which a patient contracts in a health-care institution.
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)
Supplying a building or house, their rooms and corridors, with fresh air. The controlling of the environment thus may be in public or domestic sites and in medical or non-medical locales. (From Dorland, 28th ed)
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)
Enzymes that act at a free C-terminus of a polypeptide to liberate a single amino acid residue.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The period of recovery following an illness.
The relationships of groups of organisms as reflected by their genetic makeup.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The sudden sensation of being cold. It may be accompanied by SHIVERING.
Infections caused by viruses of the genus ARTERIVIRUS.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
Semi-synthetic complex derived from nucleic-acid free viral particles. They are essentially reconstituted viral coats, where the infectious nucleocapsid is replaced by a compound of choice. Virosomes retain their fusogenic activity and thus deliver the incorporated compound (antigens, drugs, genes) inside the target cell. They can be used for vaccines (VACCINES, VIROSOME), drug delivery, or gene transfer.
Physicians or other qualified individuals responsible for implementing and overseeing the policies and procedures followed by a health care facility to reduce the risk of infection to patients and staff.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
Inflammation of the lung parenchyma that is caused by a viral infection.
The concept pertaining to the health status of inhabitants of the world.
Clothing designed to protect the individual against possible exposure to known hazards.
The activities and endeavors of the public health services in a community on any level.
Elements of limited time intervals, contributing to particular results or situations.
Diseases of domestic swine and of the wild boar of the genus Sus.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).
Events, characteristics, or other definable entities that have the potential to bring about a change in a health condition or other defined outcome.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)
Proteins prepared by recombinant DNA technology.
A severe form of acute INFLAMMATION of the PANCREAS characterized by one or more areas of NECROSIS in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. Massive pancreatic necrosis may lead to DIABETES MELLITUS, and malabsorption.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.
A PREDNISOLONE derivative with similar anti-inflammatory action.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
A weight-carrying structure for navigation of the air that is supported either by its own buoyancy or by the dynamic action of the air against its surfaces. (Webster, 1973)
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
Disease having a short and relatively severe course.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Diagnostic procedures involving immunoglobulin reactions.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.

Outbreak of severe acute respiratory syndrome--worldwide, 2003. (1/980)

Since late February 2003, CDC has been supporting the World Health Organization (WHO) in the investigation of a multicountry outbreak of atypical pneumonia of unknown etiology. The illness is being referred to as severe acute respiratory syndrome (SARS). This report describes the scope of the outbreak, preliminary case definition, and interim infection control guidance for the United States.  (+info)

Identification of severe acute respiratory syndrome in Canada. (2/980)

BACKGROUND: Severe acute respiratory syndrome (SARS) is a condition of unknown cause that has recently been recognized in patients in Asia, North America, and Europe. This report summarizes the initial epidemiologic findings, clinical description, and diagnostic findings that followed the identification of SARS in Canada. METHODS: SARS was first identified in Canada in early March 2003. We collected epidemiologic, clinical, and diagnostic data from each of the first 10 cases prospectively as they were identified. Specimens from all cases were sent to local, provincial, national, and international laboratories for studies to identify an etiologic agent. RESULTS: The patients ranged from 24 to 78 years old; 60 percent were men. Transmission occurred only after close contact. The most common presenting symptoms were fever (in 100 percent of cases) and malaise (in 70 percent), followed by nonproductive cough (in 100 percent) and dyspnea (in 80 percent) associated with infiltrates on chest radiography (in 100 percent). Lymphopenia (in 89 percent of those for whom data were available), elevated lactate dehydrogenase levels (in 80 percent), elevated aspartate aminotransferase levels (in 78 percent), and elevated creatinine kinase levels (in 56 percent) were common. Empirical therapy most commonly included antibiotics, oseltamivir, and intravenous ribavirin. Mechanical ventilation was required in five patients. Three patients died, and five have had clinical improvement. The results of laboratory investigations were negative or not clinically significant except for the amplification of human metapneumovirus from respiratory specimens from five of nine patients and the isolation and amplification of a novel coronavirus from five of nine patients. In four cases both pathogens were isolated. CONCLUSIONS: SARS is a condition associated with substantial morbidity and mortality. It appears to be of viral origin, with patterns suggesting droplet or contact transmission. The role of human metapneumovirus, a novel coronavirus, or both requires further investigation.  (+info)

A cluster of cases of severe acute respiratory syndrome in Hong Kong. (3/980)

BACKGROUND: Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder. METHODS: We abstracted data on the clinical presentation and course of disease in 10 epidemiologically linked Chinese patients (5 men and 5 women 38 to 72 years old) in whom SARS was diagnosed between February 22, 2003, and March 22, 2003, at our hospitals in Hong Kong, China. RESULTS: Exposure between the source patient and subsequent patients ranged from minimal to that between patient and health care provider. The incubation period ranged from 2 to 11 days. All patients presented with fever (temperature, >38 degrees C for over 24 hours), and most presented with rigor, dry cough, dyspnea, malaise, headache, and hypoxemia. Physical examination of the chest revealed crackles and percussion dullness. Lymphopenia was observed in nine patients, and most patients had mildly elevated aminotransferase levels but normal serum creatinine levels. Serial chest radiographs showed progressive air-space disease. Two patients died of progressive respiratory failure; histologic analysis of their lungs showed diffuse alveolar damage. There was no evidence of infection by Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila. All patients received corticosteroid and ribavirin therapy a mean (+/-SD) of 9.6+/-5.42 days after the onset of symptoms, and eight were treated earlier with a combination of beta-lactams and macrolide for 4+/-1.9 days, with no clinical or radiologic efficacy. CONCLUSIONS: SARS appears to be infectious in origin. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from which the syndrome derives its name. The microbiologic origins of SARS remain unclear.  (+info)

Update: Outbreak of severe acute respiratory syndrome--worldwide, 2003. (4/980)

CDC continues to support the World Health Organization (WHO) in the investigation of a multicountry outbreak of unexplained atypical pneumonia referred to as severe acute respiratory syndrome (SARS). This report includes summaries of the epidemiologic investigations and public health responses in several affected locations where CDC is collaborating with international and national health authorities. This report also describes an unusual cluster of cases associated with a hotel in Hong Kong and identifies the potential etiologic agent of SARS. Epidemiologic and laboratory investigations of SAPS are ongoing.  (+info)

Preliminary clinical description of severe acute respiratory syndrome. (5/980)

Severe acute respiratory syndrome (SARS) is a condition of unknown etiology that has been described in patients in Asia, North America, and Europe. This report summarizes the clinical description of patients with SARS based on information collected since mid-February 2003 by the World Health Organization (WHO), Health Canada, and CDC in collaboration with health authorities and clinicians in Hong Kong, Taiwan, Bangkok, Singapore, the United Kingdom, Slovenia, Canada, and the United States. This information is preliminary and limited by the broad and necessarily nonspecific case definition.  (+info)

A major outbreak of severe acute respiratory syndrome in Hong Kong. (6/980)

BACKGROUND: There has been an outbreak of the severe acute respiratory syndrome (SARS) worldwide. We report the clinical, laboratory, and radiologic features of 138 cases of suspected SARS during a hospital outbreak in Hong Kong. METHODS: From March 11 to 25, 2003, all patients with suspected SARS after exposure to an index patient or ward were admitted to the isolation wards of the Prince of Wales Hospital. Their demographic, clinical, laboratory, and radiologic characteristics were analyzed. Clinical end points included the need for intensive care and death. Univariate and multivariate analyses were performed. RESULTS: There were 66 male patients and 72 female patients in this cohort, 69 of whom were health care workers. The most common symptoms included fever (in 100 percent of the patients); chills, rigors, or both (73.2 percent); and myalgia (60.9 percent). Cough and headache were also reported in more than 50 percent of the patients. Other common findings were lymphopenia (in 69.6 percent), thrombocytopenia (44.8 percent), and elevated lactate dehydrogenase and creatine kinase levels (71.0 percent and 32.1 percent, respectively). Peripheral air-space consolidation was commonly observed on thoracic computed tomographic scanning. A total of 32 patients (23.2 percent) were admitted to the intensive care unit; 5 patients died, all of whom had coexisting conditions. In a multivariate analysis, the independent predictors of an adverse outcome were advanced age (odds ratio per decade of life, 1.80; 95 percent confidence interval, 1.16 to 2.81; P=0.009), a high peak lactate dehydrogenase level (odds ratio per 100 U per liter, 2.09; 95 percent confidence interval, 1.28 to 3.42; P=0.003), and an absolute neutrophil count that exceeded the upper limit of the normal range on presentation (odds ratio, 1.60; 95 percent confidence interval, 1.03 to 2.50; P=0.04). CONCLUSIONS: SARS is a serious respiratory illness that led to significant morbidity and mortality in our cohort.  (+info)

Identification of a novel coronavirus in patients with severe acute respiratory syndrome. (7/980)

BACKGROUND: The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS: Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS: A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent of the nucleotide sequence). On the basis of the obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS: The novel coronavirus might have a role in causing SARS.  (+info)

A novel coronavirus associated with severe acute respiratory syndrome. (8/980)

BACKGROUND: A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS: We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS: None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throat-swab specimen. Electron-microscopical examination revealed ultrastructural features characteristic of coronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment of the polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS: A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because of the death of Dr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.  (+info)

MERS is caused by a virus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which belongs to the Coronavirus family of viruses. MERS Virus belongs to the genus Betacoronavirus. Coronavirus family of viruses includes viruses that usually cause respiratory tract illnesses like the common cold in human beings, and also, these viruses cause a number of diseases in animals. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) causes Severe Acute Respiratory Syndrome (SARS).. Continue reading → ...
Severe Acute Respiratory Syndrome (SARS) Definition Severe acute respiratory syndrome (SARS) is the first emergent and highly transmissible viral disease to appear during the twenty-first century.
Lu P, Zhou B, et al. Chest x-ray imaging of patients with SARS. Chin Med J. 2003;116(7):972-975.. Severe acute respiratory syndrome. American Lung Association website. Available at: http://www.lung.org/lung-disease/severe-acute-respiratory-syndrome. Accessed December 22, 2014.. Severe acute respiratory syndrome (SARS). Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/sars. Updated April 16, 2013. Accessed December 22, 2014.. ...
Compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hope to provide some references for obstetric treatment and management. A total of 18 patients with COVID-19 treated at Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis. 1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to imaging examinations: 15 (83%) cases
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We therefore undertook an analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient ...
Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41±14 (range 18-83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates.
The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2 +) cells were widely distributed in the upper respiratory tract, and ACE2 + epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention. Copyright © 2011, American Society for Microbiology. All Rights Reserved ...
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein domains and host responses that contribute to rSARS-CoV-MA15-ΔE attenuation, several mutants (rSARS-CoV-MA15-E*) containing point mutations or deletions in the amino-terminal or the carboxy-terminal regions of E protein, respectively, were generated. Amino acid substitutions in the amino terminus, or deletion of domains in the internal carboxy terminal region of E protein led to viral attenuation. Attenuated viruses induced minimal lung injury and limited neutrophil influx to the lungs but, interestingly, increased CD4+ and CD8+ T cell counts in BALB/c mice. To analyze the host responses leading to rSARS-CoV-MA15-E* attenuation, the differential gene expression elicited by the native virus and the mutant ones in infected cells was analyzed. The
Severe acute respiratory syndrome (SARS) [1] was an atypical pneumonia.[2] It started in November 2002 in Guangdong Province, in the city of Foshan, of the Peoples Republic of China. The disease was caused by the SARS coronavirus (SARS CoV), a new coronavirus. It was also a part-time STD, it can be spread through both sexual and casual contact. SARS was first reported in Asia in February 2003. Over the next few months, the illness spread to more than 24 countries in Asia, North America, South America, and Europe before the SARS global outbreak of 2003 was contained. According to the World Health Organization (WHO), a total of 8098 people worldwide became sick with SARS during the 2003 outbreak; 774 of these died. After the Chinese government suppressed news of the SARS outbreak, the disease spread rapidly, reaching Hong Kong and Vietnam in late February 2003, and then to other countries via international travellers. The last case in this outbreak occurred in June 2003. There were a total of ...
Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB. Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. J Virol. 2015 Dec; 89(23):11820-33 ...
Severe acute respiratory syndrome (SARS) is the first emergent and highly transmissible viral disease to appear during the twenty-first century. Patients with SARS develop flu-like fever, headache, malaise, dry cough and other breathing difficulties. Many patients develop pneumonia, and in 5-10% of cases, the pneumonia and other complications are severe enough to cause death. SARS is caused by a virus that is transmitted usually from person to person-predominantly by the aerosolized droplets of virus infected material.. SARS cases provided a test of recent reforms in International Health Regulations designed to increase surveillance and reporting of infectious diseases-and to enhance cooperation in preventing the international spread of disease. Although not an act of bioterrorism, because the very same epidemiologic principles and isolation protocols might be used to both initially determine and initially respond to an act of bioterrorism, intelligence and public heath officials closely ...
The world is currently witnessing a major devastating pandemic of Coronavirus disease-2019 (COVID-19). This disease is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). It primarily affects the respiratory tract and particularly the lungs. The virus enters the cell by attaching its spike-like surface projections to the angiotensin-converting enzyme-2 (ACE-2) expressed in various tissues. Though the majority of symptomatic patients have mild flu-like symptoms, a significant minority develop severe lung injury with acute respiratory distress syndrome (ARDS), leading to considerable morbidity and mortality. Elderly patients with previous cardiovascular comorbidities are particularly susceptible to severe clinical manifestations. Currently, our limited knowledge of the pathologic findings is based on post-mortem biopsies, a few limited autopsies, and very few complete autopsies. From these reports, we know that the virus can be found in various organs but the
Dear Reader,. Thanks for the props! And glad to be of service.. SARS is a serious health concern, and it can be dangerous if you come into contact with it. However, you dont necessarily need to be concerned. The media grasped onto the sensationalized story of SARS because of its rapid spread made possible by the relatively new phenomenon of extensive and frequent world travel and the fast rate of transmission. Luckily the virus was quickly isolated and contained only months after its initial out-break.. SARS, which is an acronym for Severe Acute Respiratory Syndrome, is a contagious and sometimes fatal respiratory illness that is actually a severe form of pneumonia. It is caused by a strain of the coronavirus, which is also the family of viruses that causes the common cold. SARS first appeared in China in 2002, and within six weeks had spread worldwide. Within a month and a half, 8,000 people were infected and 800 had died. SARS dramatically taught us how rapidly world travel can spread ...
Severe acute respiratory syndrome (SARS-CoV-2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is characterized by severe ventilation perfusion mismatch leading to refractory hypoxemia. To date, there is no specific treatment available for 2019-nCoV. Nitric oxide is a selective pulmonary vasodilator gas used as a rescue therapy in refractory hypoxemia due to acute respiratory distress syndrome (ARDS). In has also shown in-vitro and clinical evidence that inhaled nitric oxide gas (iNO) has antiviral activity against other strains of coronavirus.. The primary aim of this study is to determine whether inhaled NO improves oxygenation in patients with hypoxic SARS-CoV2.. This is a multicenter randomized controlled trial with 1:1 individual allocation. Patients will be blinded to the treatment.. Intubated patients admitted to the intensive care unit with confirmed SARS-CoV-2 infection and severe hypoxemia will be randomized to receive inhalation of NO (treatment group) or not ...
Severe acute respiratory syndrome (SARS) is a highly contagious, serious and potentially life-threatening form of pneumonia. (SARS (Severe syndrome))
On March 21, 2003, this report was posted on the MMWR website (http://www.cdc.gov/mmwr). Severe acute respiratory syndrome (SARS) is a condition of unknown etiology that has been described in patients in Asia, North America, and Europe. This report summarizes the clinical description of patients with SARS based on information collected since mid-February 2003 by the World Health Organization (WHO), Health Canada, and CDC in collaboration with health authorities and clinicians in Hong Kong, Taiwan, Bangkok, Singapore, the United Kingdom, Slovenia, Canada, and the United States. This information is preliminary and limited by the broad and necessarily nonspecific case definition. As of March 21, 2003, the majority of patients identified as having SARS have been adults aged 25--70 years who were previously healthy. Few suspected cases of SARS have been reported among children aged ,15 years. The incubation period for SARS is typically 2--7 days; however, isolated reports have suggested an incubation ...
Severe Acute Respiratory Syndrome related to Coronavirus-2 (SARS-CoV-2), coronavirus disease-2019 (COVID-19) may cause severe illness in 20% of individuals. JAK inhibitors, corticosteroids, immunoglobulins, heparins, angiotensin-converting enzyme agonists and statins in severe COVID-19. In severe instances, COVID-19 with MAS happens in individuals with ARDS, sepsis and septic shock, and ultimately, multiorgan failure and death, linked to sustained IL-6 and IL-1 elevation. While slight medical forms only require symptomatic management, in moderate-severe forms in-hospital monitoring with general actions plus antivirus and/or HCQ administration is necessary. However, in more severe and life-threating instances, a high intensity pharmacological treatment is recommended. The pathogenesis of the acute pulmonary injury related to COVID-19 is very similar that happen in additional disorders that induce high hyperinflammatory state with a launch of high amounts of pro-inflammatory cytokine primarily, ...
The WHO Global Conference on Severe Acute Respiratory Syndrome (SARS), was held in the Sunway Lagoon Resort Hotel, Persiaran Lagoon, Bandar Sunway, 46150, Petaling Jaya, Selangor Darul Ehsan, Kuala Lumpur, Malaysia on 17-18 June 2003.. ...
Severe acute respiratory syndrome (SARS) was caused by a previously unrecognized animal coronavirus that exploited opportunities provided by wet markets in southern China to adapt to become a virus readily transmissible between humans. Hospitals and international travel proved to be amplifiers t …
In his second week of severe acute respiratory syndrome (SARS) illness, a patient developed an unusually complicated course of acute coronary syndrome. One day after initial stabilization of a non-ST-elevated anterior myocardial infarction (MI), he sustained an ST-elevated anterior MI. Eight hours a …
We estimated the incubation period of severe acute respiratory syndrome based on a subset of patients with available data on exposure periods and a separate subset of patients in a putative common source outbreak, and we found associations between shorter incubation period and greater severity in both groups after adjusting for potential confounders ...
Liu, E.H.,Koh, K.-F.,Chen, F.-G. (2004). Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13]. Anesthesiology 100 (6) : 1629-1630. [email protected] Repository ...
Liu, E.H., Koh, K.-F., Chen, F.-G. (2004-06). Outbreak of severe acute respiratory syndrome in Singapore and modifications in the anesthesia service [13]. Anesthesiology 100 (6) : 1629-1630. [email protected] Repository ...
Negative public reactions to emerging infectious diseases can adversely affect population health. We assessed whether social support was associated with knowledge of, worry about, and attitudes towards AIDS and severe acute respiratory syndrome. Our findings suggest that social support may be central to our understanding of public responses to emerging infectious diseases.
The global outbreak caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been declared a pandemic by the WHO. As the number of imported SARS-CoV-2 cases is on the rise in Brazil, we use incidence and historical air travel data to estimate the most important routes of importation into the country.
Most cases of severe acute respiratory syndrome (SARS) have occurred in close contacts of SARS patients. However, in Beijing, a large proportion of SARS cases occurred in persons without such contact. We conducted a case-control study in Beijing that compared exposures of 94 unlinked, probable SARS patients with those of 281 community-based controls matched for age group and sex. Case-patients were more likely than controls to have chronic medical conditions or to have visited fever clinics (clinics at which possible SARS patients were separated from other patients), eaten outside the home, or taken taxis frequently. The use of masks was strongly protective. Among 31 case-patients for whom convalescent-phase (>21 days) sera were available, 26% had immunoglobulin G to SARS-associated coronavirus. Our finding that clinical SARS was associated with visits to fever clinics supports Beijings strategy of closing clinics with poor infection-control measures. Our finding that mask use lowered the risk ...
Aim: This study describes the experiences of parents of hospitalized dying children during the SARS (severe acute respiratory syndrome) outbreak in southern Ontario, Cana..
While Toronto recovers from the lingering effects of its Severe Acute Respiratory Syndrome outbreak, health experts are worried the city is poised for an ...
Despite difficult challenges during responses to the terrorist attacks of September 11, 2001, Hurricane Katrina, and the 2009 Pandemic Influenza A/H1N1 and severe acute respiratory syndrome outbreaks, no North American emergency to date has overwhelmed intensive care unit (ICU) services on a widespread basis since the modern development of the field of critical care. However, planners have recognized that in a future public health emergency we may not be so fortunate. To deal with very large emergencies involving many patients whose survival depends on immediate access to intensive care, an international Task Force for Mass Critical Care proposed recommendations in January 2007 to extend critical care resources for the adult population, referred to as the Emergency Mass Critical Care (EMCC) approach (1-5).. The EMCC approach triples critical care capabilities for a period of up to 10 days in a very large public health emergency by focusing on immediately life-saving interventions, while delaying ...
We have systematically described the clinical characteristics of 96 patients with covid-19 and described the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) loads and disease progression in 3497 samples of multiple types, revealing the interaction between SARS-CoV-2 replication and clearance by host defence mechanisms. The median duration of virus in respiratory samples was 18 days, which was consistent with the median duration of 20 days for Middle East respiratory syndrome (MERS).12 Peak viral shedding in respiratory specimens of patients with severe acute respiratory syndrome (SARS) occurred after about 10 to 12 days from symptom onset,1314 which is similar to the peak observed for SARS-CoV-2 in our study. Consistent with earlier reports of SARS-CoV-2,15 we found differences in the viral load in patients with different disease severities, those with severe disease showing a significantly higher viral load than those with mild disease, which suggests that viral ...
SARS is mainly spread by close person-to-person contact. After two to seven days, SARS patients may develop a dry cough with most developing pneumonia.
this news reminded me a bit different thing. recently Japanese TV reported that theres growing number of pulmonary edema like symptom spreading widely in Japan, caused by spraying anti-rain coating chemical such as ScotchGuard in closed air space like inside of cars or houses. people here often use such chemicals spray on skiwears and shoes before going to ski, then get sudden breathing problem during skiing and then hospitalized. if theres no virus or bacterium found on this SARS case, Im curious to other type of chemicals in relation. BTW you can even make vapor that causes temporary breathing problems by just burning red pepper in oil. dont try this at home. (I accidentally did while cooking curry. it was horrible.). ...
The number of SARS cases, and the number of countries reporting such cases, continues to increase worldwide. Transmission within hospitals and households continues in some areas, and transmission within communities (e.g., Hong Kong) continues to be reported. In the absence of a complete understanding of how SARS is transmitted, efforts to limit transmission in the United States have focused on early identification of potential cases through surveillance and implementation of infection-control measures in health-care settings and the community. CDC has developed interim infection-control guidelines for use in U.S. health-care and household settings (8). These recommendations are based on experience in the United States to date and will be revised as more information becomes available. Infection-control practitioners and clinicians providing medical care for patients with suspected SARS should consult these guidelines frequently to keep current with recommendations. Transmission in health-care ...
In the present study we investigated, for the first time, the susceptibility of primary human Mφ and DC and their subsequent responses to SARS-CoV infection by focusing on their phenotypic expression, secretion of inflammatory cytokines, phagocytic activity, and T cell-priming capacity. The findings of our studies are: 1) SARS-CoV could not productively infect Mφ and DC (Figs. 1⇑ and 2⇑); 2) incubation with SARS-CoV did not add to the spontaneous cell death of primary Mφ and DC; on the contrary, it enhanced their viability (Fig. 3⇑) independently of the presence of exogenous cytokines; 3) exposure to live SARS-CoV exerted a diverse effect on the biology of DC vs Mφ, in which it up-regulated the expression of MHC class II, CD40, CD83, and CD86, on the surface of DC but not Mφ. Consequently, it also greatly enhanced DC ability to stimulate the proliferation of allogeneic T cells (Figs. 4⇑ and 8⇑). In contrast, it impaired the phagocytic activity of Mφ (Fig. 7⇑); and 4) not only ...
During the 2003 severe acute respiratory syndrome (SARS) outbreak, a real-time quantitative polymerase chain reaction, which targets the nucleocapsid gene at the 3′-end of the viral genome, was established to detect and identify the SARS-associated coronavirus. We describe the use of this assay to screen |700 clinical samples.
The main findings of this study were: 1) residual pulmonary function defects were detected in half of the recovered SARS patients 3 months after hospital discharge, but the impairment was mild in almost all cases; and 2) 41% of the patients had impairment of exercise capacity not due to ventilatory limitation.. Abnormality in TL,CO was the most common cause of impairment in pulmonary function in the patients in the current study. This finding is consistent with a follow-up study 18 of 89 patients with SARS ranging 0.5-3.4 months during the convalescent period, in which mild-to-moderate abnormalities in pulmonary function were found in 48 patients (54%). TL,CO was impaired in 38 patients (43%); in seven patients (8%), lung function was restrictive defect combined with TL,CO impairment. However, direct comparison with other studies cannot be made as, unlike the present study, pulmonary function testing was not performed at uniform time-points in any of the previous studies on recovered SARS ...
The critical importance of TLR signaling programs is demonstrated by the key regulation of host immune responses by TLR adaptor proteins MyD88 and TRIF in controlling respiratory virus infections. In SARS-CoV-infected TRIF−/− mice, there is significantly increased mortality, weight loss, and viral titers (Fig. 3A and B), leading to expression of cytokines, chemokines, and ISGs (Fig. 6; see also Fig. S4 in the supplemental material) consistent with the aberrant cellular signaling programs seen in patients who succumbed to SARS or MERS disease (44, 45). Although MyD88−/− mice infected with SARS-CoV had mortality, weight loss, and viral loads comparable to those of TRIF−/− mice infected with SARS-CoV, the outcomes in downstream cellular signaling programs were very different (37). In MyD88−/− mice infected with SARS-CoV, there was an absence of induction of cytokine and chemokine signaling at days 2, 4, and 6 postinfection compared to wild-type mice; in contrast, TRIF−/− mice ...
In March of 2003, an outbreak of Severe Acute Respiratory Syndrome (SARS) occurred in Northern Vietnam. This outbreak began when a traveler arriving from Hong Kong sought medical care at a small hospital (Hospital A) in Hanoi, initiating a serious and substantial transmission event within the hospital, and subsequent limited spread within the community. We surveyed Hospital A personnel for exposure to the index patient and for symptoms of disease during the outbreak. Additionally, serum specimens were collected and assayed for antibody to SARS-associated coronavirus (SARS-CoV) antibody and job-specific attack rates were calculated. A nested case-control analysis was performed to assess risk factors for acquiring SARS-CoV infection. One hundred and fifty-three of 193 (79.3%) clinical and non-clinical staff consented to participate. Excluding job categories with |3 workers, the highest SARS attack rates occurred among nurses who worked in the outpatient and inpatient general wards (57.1, 47.4%,
Using the purified proteins as antigens in ELISA assays for antibodies in the sera of SARS patients we found that the assay using truncated S-N fusion protein has a clearly higher sensitivity than those using intact N protein or truncated S and N proteins, and virtually as high as the assay using whole SARSCoV lysate (Table 2). The results indicated the N and S protein were complementary in detecting SARS-specific antibodies. This is consistent with previous studies [28, 29]. Five positive sera to SARSCoV lysate antigen were all tested positive against SARSCoV N protein but negative against SARSCoV truncated N-S protein. These sera were also tested positive against N proteins of HCoV 229E and HCoV OC43 (data not shown), which could be reasonably explained partly by existence of other HCoV infections in these humans. The truncated S-N fusion protein was also subjected to ELISA with mice antisera against SARSCoV (BJ01), HCoV 229E and HCoV OC43. Only mice antiserum against SARSCoV(BJ01) tests ...
Severe acute respiratory syndrome (SARS) originated in southern China in November 2002, and soon spread to people on six continents, killing nearly 800 people all told. For the first time, researchers have identified a crucial SARS receptor in vivo that helps explain how and why SARS infection causes lung failure. The findings should help researchers treat other diseases that compromise lung function. Previous research using cell lines had identified ACE2, a protein involved in regulating blood pressure, as a potential SARS receptor. Now Josef Penninger of the Institute of Molecular Biotechnology (IMBA) in Vienna, Austria, and his colleagues have tested the hypothesis in mice. In a paper published online yesterday by Nature Medicine, they report that SARS infection, and specifically the SARS protein known as Spike, reduces ACE2 expression. As a result, blood vessels in the lungs become damaged and the lung becomes flooded as a result. In a second paper published in the current issue of the ...
SARS Case Study. You are the director of communicable diseases in a city health department, responsible for a large urban community. It is early spring in 2003. For the past two years, your department has been working to control the spread of the West Nile Virus and you are pleased with the progress so far. This morning you read about a suspected outbreak of a new disease called SARS which is suspected to have killed dozens of people in Hong Kong. While West Nile Virus is carried by birds, especially crows, SARS is transmitted among people.. When you get to the office and check your email you learn that the World Health Organization has placed a number of East Asian cities off limits for all but essential travel. You also learn that Canada has reported deaths they believe are due to SARS. You are now confronted with addressing a new and virulent contagious disease.. Based on your understanding of the SARS case study, answer the following questions:. ...
The risk factors for SARS are close contact within the previous 10 days with a probable case of SARS, recent travel within the previous 10 days to a reported affected area.
The lungs and gastrointestinal tract have been demonstrated to be the only major organ systems that support SARS-CoV replication. After establishment of infection, SARS-CoV causes tissue damage by (1) direct lytic effects on host cells and (2) indirect consequences resulting from the host immune response.
TY - JOUR. T1 - Quantitation of severe acute respiratory syndrome coronavirus genome by real-time polymerase chain reaction assay using minor groove binder DNA probe technology. AU - Lin, Hsi Hsun. AU - Wang, Shiow J.. AU - Liu, Yung Ching. AU - Lee, S. S J. AU - Hwang, Chun K.. AU - Chen, Yao Shen. AU - Wann, Shue R.. AU - Shih, Yi L.. PY - 2004/10. Y1 - 2004/10. N2 - The ability to rapidly recognize severe acute respiratory syndrome coronavirus (SARS-CoV) as a cause of infections is critical to quickly limiting further spread of the disease. A rapid, sensitive, and specific laboratory diagnostic test is needed to confirm outbreaks of SARS-CoV infection and distinguish it from other diseases that can cause similar clinical symptoms. An improved TaqMan technology using minor groove binder (MGB) probes was used to detect and quantify SARS-CoV in suspected patients. SARS-CoV primers and probe were designed based on the open reading frame 1b sequence, which encodes coronavirus replicase protein. A ...
The coronavirus disease 2019 (COVID-19) pandemic is associated with significant morbidity and mortality throughout the world, predominantly due to lung and cardiovascular injury. The virus responsible for COVID-19-severe acute respiratory syndrome coronavirus 2-gains entry into host cells via ACE2 (angiotensin-converting enzyme 2). ACE2 is a primary enzyme within the key counter-regulatory pathway of the renin-angiotensin system (RAS), which acts to oppose the actions of Ang (angiotensin) II by generating Ang-(1-7) to reduce inflammation and fibrosis and mitigate end organ damage. As COVID-19 spans multiple organ systems linked to the cardiovascular system, it is imperative to understand clearly how severe acute respiratory syndrome coronavirus 2 may affect the multifaceted RAS. In addition, recognition of the role of ACE2 and the RAS in COVID-19 has renewed interest in its role in the pathophysiology of cardiovascular disease in general. We provide researchers with a framework of best practices ...
1. PerlmanS, NetlandJ (2009) Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol 7: 439-450.. 2. RotaPA, ObersteMS, MonroeSS, NixWA, CampganoliR, et al. (2003) Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300: 1394-1399.. 3. DrostenC, GuntherS, PreiserW, van der WerfS, BrodtHR, et al. (2003) Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348: 1967-1976.. 4. PyrcK, BerkhoutB, van der HoekL (2007) The novel human coronaviruses NL63 and HKU1. J Virol 81: 3051-3057.. 5. ZakiAM, van BoheemenS, BestebroerTM, OsterhausAD, FouchierRA (2012) Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367: 1814-1820.. 6. DanielssonN, CatchpoleM (2012) Novel coronavirus associated with severe respiratory disease: case definition and public health measures. Euro Surveill 17: 20282.. 7. AssiriA, McGeerA, PerlTM, PriceCS, Al RabeeahAA, et al. ...
TY - JOUR. T1 - Emergency medical services utilization during an outbreak of severe acute respiratory syndrome (SARS) and the incidence of SARS-associated coronavirus infection among emergency medical technicians. AU - Chow-In Ko, Patrick. AU - Chen, Wen Jone. AU - Huei-Ming Ma, Matthew. AU - Chiang, Wen Chu. AU - Su, Chan Ping. AU - Huang, Chien Hua. AU - Lu, Tsung Chien. AU - Shih, Fuh Yuan. AU - Lin, Fang Yue. PY - 2004/9/1. Y1 - 2004/9/1. N2 - Objectives This was a study to evaluate the utilization of emergency medical services (EMS) systems during the outbreak of severe acute respiratory syndrome (SARS), and to assess the incidence of infection among emergency medical technicians (EMTs). Methods This was a prospective, observational study conducted in the EMS system of Taipei, Taiwan. Probable/suspect cases of SARS were defined by World Health Organization criteria. SARS-related transports were categorized into 1) requests from hospitals for probable/suspect cases of SARS, 2) quarantined ...
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-O-galloyl-beta-D-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 microM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of ...
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) emerged in 2002/2003, causing the deaths of almost a tenth of the 8000 individuals infected worldwide before it was controlled by public health measures. While the 2003 epidemic strain is likely extinct, the importance of coronaviruses as emergent zoonotic viruses was again realized with the emergence of a novel human coronavirus in Saudi Arabia in 2012. Despite a decade of research on SARS-CoV no approved vaccine or therapeutic yet exists, and development of broadly neutralizing and effective therapeutics for coronaviruses remains a priority. Neutralizing antibodies targeting the Spike glycoprotein (S) are both necessary and sufficient for protection against SARS-CoV, but the high genetic diversity and mutability of SARS-CoV in natural infections presents a challenge to both vaccine- and antibody-based therapeutics. Thus, an effective SARS-CoV therapeutic should provide S-specific immunity that is nonetheless broad enough to counter ...
The emerging pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge for healthcare systems globally. quickly underway to build up potential therapeutic real estate agents and vaccines (Antithrombotic Therapy, 2020; Coronavirus, 2020; Epidemiological, 2020; Lexicomp for Dentistry, 2020; Zhang et al., 2020). 8.1. Anti-viral real estate agents 8.1.1. Remdesivir Remdesivir was initially developed through the peak from XL413 the Ebola disease outbreak in 2016, and offers been proven to become the most guaranteeing therapy in dealing with COVID-19 (Ko et al., 2020; Sanders et al., 2020). It really is a broad-spectrum anti-viral agent that works as an inhibitor of RNA-dependent RNA polymerase, an enzyme necessary for viral replication (Fig. 1.) (Kupferschmidt, 2020). Although Remdesivir failed in medical tests for treatment of Ebola in 2014, it really is thought as a safe drug. Similar to the doses ...
As a contribution to the global efforts to track and trace the ongoing coronavirus pandemic, here we present the sequence, phylogenetic analysis, and modeling of nonsynonymous mutations for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome that was detected in a South African patient with coronavirus disease 2019 (COVID-19 ...
To the Editor Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged i
UNLABELLED: The receptor binding domain (RBD) of the spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) is a major target of protective immunity in vivo. Although a large number of neutralizing antibodies (nAbs) have been developed, it remains unclear if a single RBD-targeting nAb or two in combination can prevent neutralization escape and, if not, attenuate viral virulence in vivo. In this study, we used a large panel of human nAbs against an epitope that overlaps the interface between the RBD and its receptor, angiotensin-converting enzyme 2 (ACE2), to assess their cross-neutralization activities against a panel of human and zoonotic SARS-CoVs and neutralization escape mutants. We also investigated the neutralization escape profiles of these nAbs and evaluated their effects on receptor binding and virus fitness in vitro and in mice. We found that some nAbs had great potency and breadth in neutralizing multiple viral strains, including neutralization escape ...
TY - JOUR. T1 - Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. AU - Bloise, Enrrico. AU - Zhang, Jianhong. AU - Nakpu, Jittanan. AU - Hamada, Hirotaka. AU - Dunk, Caroline E.. AU - Li, Siliang. AU - Imperio, Guinever E.. AU - Nadeem, Lubna. AU - Kibschull, Mark. AU - Lye, Phetcharawan. AU - Matthews, Stephen G.. AU - Lye, Stephen J.. N1 - Funding Information: E.B. is supported by the Higher Education Personnel Improvement Coordination (Coordena??o de Aperfei?oamento Pessoal de N?vel Superior [CAPES]; finance code 001, CAPES-Print fellowship). S.J.L. is supported by a grant (FDN-143262) from the Canadian Institutes of Health Research (CIHR). S.G.M. is also supported by a grant (FDN-148368) from the CIHR. Funding Information: E.B. is supported by the Higher Education ...
The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)in China threatened humankind worldwide. The coronaviruses contains the largest RNA genome among all other known RNA viruses, therefore the disease etiology can be understood by analyzing the genome sequence of SARS-CoV-2. In this study, we used an ab-intio based computational tool VMir to scan the complete genome of SARS-CoV-2 to predict pre-miRNAs. The potential pre-miRNAs were identified by ViralMir and mature miRNAs were recognized by Mature Bayes. Additionally, predicted mature miRNAs were analysed against human genome by miRDB server to retrieve target genes. Besides that we also retrieved GO (Gene Ontology) terms for pathways, functions and cellular components. We predicted 26 mature miRNAs from genome of SARS-CoV-2 that targets human genes involved in pathways like EGF receptor signaling, apoptosis signaling, VEGF signaling, FGF receptor signaling. Gene enrichment tool analysis and substantial literature
Shi, Y.; Yi, Y.; Li, P.; Kuang, T.; Li, L.; Dong, M.; Ma, Q.; Cao, C., 2003: Diagnosis of severe acute respiratory syndrome (SARS) by detection of SARS coronavirus nucleocapsid antibodies in an antigen-capturing enzyme-linked immunosorbent assay
LOCUS MW040663 29809 bp RNA linear VRL 27-SEP-2020 DEFINITION Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/FL-BPHL-1453/2020 ORF1ab polyprotein (ORF1ab), ORF1a polyprotein (ORF1ab), surface glycoprotein (S), ORF3a protein (ORF3a), envelope protein (E), membrane glycoprotein (M), and ORF6 protein (ORF6) genes, complete cds; ORF7a protein (ORF7a) and ORF7b (ORF7b) genes, partial cds; and ORF8 protein (ORF8), nucleocapsid phosphoprotein (N), and ORF10 protein (ORF10) genes, complete cds. ACCESSION MW040663 VERSION MW040663.1 KEYWORDS . SOURCE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORGANISM Severe acute respiratory syndrome coronavirus 2 Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus. REFERENCE 1 (bases 1 to 29809) AUTHORS Schmedes,S. and Blanton,J. TITLE Direct Submission JOURNAL Submitted (25-SEP-2020) BPHL, FLDOH, 1217 N Pearl St, ...
Only a minority of probable SARS cases caused transmission. We assess if any epidemiological or clinical factors in SARS index patients were associated with increased probability of transmission. We used epidemiological and clinical data on probable SARS patients admitted to Tan Tock Seng Hospital. Using a case-control approach, index patients who had probable SARS who subsequently transmitted the disease to at least one other patient were analysed as cases against patients with no transmission as controls, using multivariate logistic regression analysis. 98 index patients were available for analysis (22 with transmission, 76 with no transmission). Covariates positively associated with transmission in univariate analysis at p | 0.05 included delay to isolation (Day 7 of illness or later), admission to a non-isolation facility, pre-existing chronic respiratory disease and immunosuppressive disease, need for oxygen, shortness of breath, vomiting, and higher lactate dehydrogenase levels and higher
Severe acute respiratory syndrome (SARS) is a viral illness. It is very contagious and can spread quickly. It can cause mild illness, severe illness, or death.
In this study, we have examined the function of the SARS-CoV S protein and the contribution of other viral membrane proteins to virus fusion and entry. We suggest that, of these gene products, the S glycoprotein is necessary and sufficient for viral gene delivery. Although the origin of SARS-CoV is unknown, recent studies have suggested that it may have been transmitted from animals to humans (6, 7, 13). During the course of the SARS-CoV epidemic, molecular evolution throughout the SARS-CoV genome was detected. In addition to mutations in several regions of SARS-CoV, specific changes that involved the deletion of a 29-nucleotide region or insertion of an 82-nucleotide region in ORF8 were observed, and it is hypothesized that these changes may have facilitated the spread of the disease (7). It is possible that SARS-CoV has arisen from recombination between different coronaviruses, although the direct antecedents of the present strain are not yet defined (15, 20, 33, 36). While SARS-CoV is not ...
SARS coronavirus (SARS-CoV) encodes several unique group-specific open reading frames (ORFs) relative to other known coronaviruses. To determine the significance of the SARS-CoV group-specific ORFs in virus replication in vitro and in mice, we systematically deleted five of the eight group-specific ORFs, ORF3a, OF3b, ORF6, ORF7a, and ORF7b, and characterized recombinant virus replication and gene expression in vitro. Deletion of the group-specific ORFs of SARS-CoV, either alone or in various combinations, did not dramatically influence replication efficiency in cell culture or in the levels of viral RNA synthesis. The greatest reduction in virus growth was noted following ORF3a deletion. SARS-CoV spike (S) glycoprotein does not encode a rough endoplasmic reticulum (rER)/Golgi retention signal, and it has been suggested that ORF3a interacts with and targets S glycoprotein retention in the rER/Golgi apparatus. Deletion of ORF3a did not alter subcellular localization of the S glycoprotein from ...
The first known infections from the SARS-CoV-2 strain were discovered in Wuhan, China.[7] The original source of viral transmission to humans and when the strain became pathogenic remains unclear.[32][33][34] Because many of the first individuals found to be infected by the virus were workers at the Huanan Seafood Market,[35][36] it has been suggested that the strain might have originated from the market.[34][37] However, other research indicates that visitors may have introduced the virus to the market, which then facilitated rapid expansion of the infections.[32][38]. Research into the natural reservoir of the virus strain that caused the 2002-2004 SARS outbreak has resulted in the discovery of many SARS-like bat coronaviruses, most originating in the Rhinolophus genus of horseshoe bats, and two viral nucleic acid sequences found in samples taken from Rhinolophus sinicus show a resemblance of 80% to SARS-CoV-2.[9][39][40] A third viral nucleic acid sequence from Rhinolophus affinis, collected ...
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC. ...
CHILDREN below the age of five could be major carriers of the coronavirus as compared to adults, a new study has found.. By Michael Gwarisa According to the study Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19), which was published in JAMA Pediatrics and led by Dr. Taylor Heald-Sargent, a pediatric infectious diseases expert at the Ann and Robert H. Lurie Childrens Hospital of Chicago, children are susceptible to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but generally present with mild symptoms compared with adults.. Children drive spread of respiratory and gastrointestinal illnesses in the population, but data on children as sources of SARS-CoV-2 spread are sparse. Early reports did not find strong evidence of children as major contributors to SARS-CoV-2 spread,3 but school closures early in pandemic responses thwarted ...
A real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was developed to rapidly detect the severe acute respiratory syndrome-associated coronavirus (SARS-CoV). The assay, based on multiple primer and probe sets located in different regions of the SARS-CoV genome, could discriminate SARS-CoV from other human and animal coronaviruses with a potential detection limit of ...
කොවිඩ්-19 එසේත් නැත්නම් කොරෝනා වෛරස් රෝගය 2019 (ඉංග්‍රීසි: Coronavirus disease 2019, COVID-19) යනු severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) වෛරසය මගින් ඇතිකරනු ලබන බෝවන රෝගයකි.[8] මෙම රෝගය මුල්වරට චීනයේ වූහාන් නුවර දී හඳුනා ගත් අතර ඉන් අනතුරුව ලොව පුරා පැතිරගොස් 2019-20 coronavirus pandemic නමින් හැඳින්වෙන ගෝලීය වසංගතය බවට වර්ධනය විය.[9][10] සාමාන්‍ය රෝග ලක්ෂණ වනුයේ උණ (fever), කැස්ස (cough) සහ හුස්ම ගැනීමේ අපහසුව (shortness of breath) වේ. මස්පිඩු වේදනාව sputum production සහ sore throat ද ...
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available. We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations. Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition
3V3M: Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease.
A new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged to cause a human pandemic. Although molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated serologic assays are needed for contact tracing, identifying the viral reservoir, and epidemiologic studies. We developed serologic assays for detection of SARS-CoV-2 neutralizing, spike protein-specific, and nucleocapsid-specific antibodies. Using serum samples from patients with PCR-confirmed SARS-CoV-2 infections, other coronaviruses, or other respiratory pathogenic infections, we validated and tested various antigens in different in-house and commercial ELISAs. We demonstrated that most PCR-confirmed SARS-CoV-2-infected persons seroconverted by 2 weeks after disease onset. We found that commercial S1 IgG or IgA ELISAs were of lower specificity, and sensitivity varied between the 2 assays; the IgA ELISA showed higher sensitivity. Overall, ...
Table 2 listed on pages 703-15 summarizes finalized data, as of June 30, 2014, from the National Notifiable Diseases Surveillance System (NNDSS) for 2013. These data will be published in more detail next year in the Summary of Notifiable Diseases - United States, 2013 (1). Because no cases were reported in the United States during 2013, the following diseases do not appear in these early release tables: anthrax; diphtheria; eastern equine encephalitis, nonneuroinvasive disease; poliovirus infection, nonparalytic; severe acute respiratory syndrome-associated coronavirus disease (SARS-CoV); smallpox; St.. ...
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
This study demonstrates that B6 mice can be productively infected by SARS-CoV in the bronchial and bronchiolar epithelium of the respiratory tract, and that virus is rapidly cleared through a mechanism independent of NK cells, NK-T cells, and T and B lymphocytes. Virus is able to spread to the brain at late time points when it has already been cleared by the lung, and may spread to multiple other organs. SARS-CoV induces dramatic up-regulation of a subset of inflammatory chemokines and the chemokine receptor CXCR3, but interestingly this occurs without detectable expression of classic proinflammatory and immunoregulatory cytokines and without evoking marked leukocyte infiltration of the lung. Overall, infected B6 mice do not develop overt disease, but their weight gain is slowed relative to mock-infected controls.. The work confirms our previously published finding that BALB/c mice can be productively and transiently infected in the terminal bronchioles. The susceptibility of the two strains to ...
Human coronaviruses were first identified in the mid-1960s.2 They are a group of diverse, enveloped, positive-sense single-stranded RNA viruses that cause respiratory, enteric, hepatic, and neurologic diseases of varied severity in a range of animals, including humans. In fact, approximately 20% of common colds are caused by coronaviruses. Most people get infected with one or more of these viruses during their lifetime.3 COVID-19 is caused by one of the three known human coronaviruses that lead to severe acute respiratory issues: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because this virus is new in humans, the research community has gained all their experience with it over the past 8 months or so. Thus, most current knowledge of how to battle SARS-CoV-2 is informed by the etiology and epidemiology of two other coronaviruses known to cause serious human disease: severe acute respiratory syndrome (SARS-CoV; SARS), which caused an outbreak in 2003 and Middle East respiratory ...
Posted on 03/18/2020 2:06:03 PM PDT by Hojczyk. Check out this 2007 article in Clinical Microbiology Reviews, titled Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection. It begins: Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is a novel virus that caused the first major pandemic of the new millennium (89, 180, 259). The rapid economic growth in southern China has led to an increasing demand for animal proteins including those from exotic game food animals such as civets. Large numbers and varieties of these wild game mammals in overcrowded cages and the lack of biosecurity measures in wet markets allowed the jumping of this novel virus from animals to human (353, 376). Its capacity for human-to-human transmission, the lack of awareness in hospital infection control, and international air travel facilitated the rapid global dissemination of this agent. Sounds familiar. The article concludes: Coronaviruses are well known to undergo ...
Severe acute respiratory syndrome (SARS). *Sick building syndrome. See also: Toxicology and List of allergies ...
a) = acronym, e.g.: SARS - (a) severe acute respiratory syndrome. (i) = initialism, e.g.: CD - (i) compact disc. (p) = pseudo- ... acronym = an abbreviation pronounced as if it were a word, e.g., SARS = severe acute respiratory syndrome, pronounced to rhyme ...
"Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak". Archived from the original on 7 December 2008. Retrieved ... severe acute respiratory syndrome (SARS) and measles. Chest radiographs (X-ray photographs) often show a pulmonary infection ... "Primary atypical pneumonia" at Dorland's Medical Dictionary Commission on Acute Respiratory Diseases, Fort Bragg, North ... Despite general symptoms and problems with the upper respiratory tract (such as high fever, headache, a dry irritating cough ...
... discoverer of Severe Acute Respiratory Syndrome (SARS) virus; proposed the Cytokine storm theory of avian influenza[45] ...
The SARS conspiracy theory began to emerge during the severe acute respiratory syndrome (SARS) outbreak in China in the spring ... "Update: Outbreak of Severe Acute Respiratory Syndrome --- Worldwide, 2003". Morbidity and Mortality Weekly Report, U.S. Centers ... Centers for Disease Control has explained that anybody with fever and a respiratory symptom who had traveled to an affected ... area was included as a SARS patient in the U.S., even though many of these were found to have had other respiratory illnesses.[ ...
"SARS , Home , Severe Acute Respiratory Syndrome , SARS-CoV Disease , CDC". www.cdc.gov. Retrieved 25 October 2020. Rittenberg ...
Severe acute respiratory syndrome (i) = initialism, e.g.: CD - (i) Compact disc (p) = pseudo-blend, e.g.: UNIFEM - (p) United ... severe acute respiratory syndrome, pronounced to rhyme with cars initialism = an abbreviation pronounced wholly or partly using ... HyperKinetic Syndrome hL - (s) Hectolitre HL - (i) Holding Line HLA - (i) High Level Architecture (simulation) - Human ...
Hui DS, Memish ZA, Zumla A (May 2014). "Severe acute respiratory syndrome vs. the Middle East respiratory syndrome". Current ... Early reports[7] compared the virus to severe acute respiratory syndrome (SARS), and it has been referred to as Saudi Arabia's ... "Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV); Fifteenth update, 8 March ... a person with a fever, respiratory infection, and evidence of pneumonia or acute respiratory distress syndrome. and. testing ...
"WHO , SARS (Severe Acute Respiratory Syndrome)". WHO. Retrieved 7 May 2020. Yang, Jun; Chen, Jinhong; Liu, Huiliang; Zheng, ... "China braces for "severe" flooding on Yangtze River". Reuters. 2 April 2016. Retrieved 8 May 2020. "Why China's massive floods ... "the most severe setback to [the] socialist cause since [1949]". In June 1981, the Chinese government's condemnation of the ...
Severe acute respiratory syndrome (SARS), often referred to as a severe form of pneumonia, is a highly contagious zoonotic ... "WHO , SARS (Severe Acute Respiratory Syndrome)". WHO. Retrieved 2019-04-18. "Monkeypox". www.who.int. Retrieved 2019-04-22. " ... respiratory illness causing extreme breathing difficulties. Factors attributing to widespread dispersal include the destruction ...
"SARS (severe acute respiratory syndrome)". nhs.uk. 2017-10-19. Retrieved 2017-12-14. "How Sleep Loss Affects Immunity". WebMD. ... Severe acute respiratory syndrome: Wikipedia's article on SARS for further information on the symptoms, diagnosis, treatments, ... "Update: Severe Acute Respiratory Syndrome --- Toronto, Canada, 2003". www.cdc.gov. Retrieved 2017-11-07. Canada, Public Health ... The rapid spread of severe acute respiratory syndrome (SARS) in healthcare workers (HCW)-most notably in Toronto hospitals- ...
... the severe acute respiratory syndrome (SARS) Coronavirus outbreak, the Middle Eastern Respiratory Syndrome (MERS) Coronavirus ... Lau YL, Peiris JS (2005). "Pathogenesis of severe acute respiratory syndrome". Curr. Opin. Immunol. 17 (4): 404-10. doi:10.1016 ... 2003). "Coronavirus as a possible cause of severe acute respiratory syndrome". Lancet. 361 (9366): 1319-25. doi:10.1016/S0140- ... Malik Peiris was the first to isolate the severe acute respiratory syndrome (SARS) virus that caused international alarm when ...
Liang, W. (2004). "Severe Acute Respiratory Syndrome, Beijing, 2003". Emerging Infectious Diseases. 10 (1): 25-31. doi:10.3201/ ... Bowen, John T.; Laroe, Christian (2006). "Airline Networks and the International Diffusion of Severe Acute Respiratory Syndrome ... "Progress in Global Surveillance and Response Capacity 10 Years After Severe Acute Respiratory Syndrome". medscape.com. ... "Transmission of the Severe Acute Respiratory Syndrome on Aircraft". New England Journal of Medicine. 349 (25): 2416-2422. doi: ...
Coronavirus as a possible cause of severe acute respiratory syndrome; J. S. M. Peiris u. a. - Der Erreger von SARS ist ... Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome; T. Kuiken u. a. - Bestätigung PMID ... Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial ... Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1; ISIS-1 ...
"Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS)". The Cochrane Database of Systematic ... "Causes and Outcomes of Acute Liver Failure in China". PLoS ONE. 8 (11): e80991. doi:10.1371/journal.pone.0080991. PMC 3838343 ... Cold (寒, pinyin: hán): cold sensations, aversion to cold, relief of symptoms by warmth, watery/clear excreta, severe pain, ... The bile is extracted through a permanent hole in the abdomen leading to the gall bladder, which can cause severe pain. This ...
Tento článok je čiastočný alebo úplný preklad článku Severe acute respiratory syndrome na anglickej Wikipédii. ... SARS (severe acute respiratory syndrome) [online]. UK National Health Service, 3 October 2014. Dostupné online. ... Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) [online]. WHO, 2003, [cit. 2021-04-08]. ... SARS (severe acute respiratory syndrome) [online]. 19 October 2017. Dostupné online. (po anglicky). ...
"Severe acute respiratory syndrome (SARS) outbreak, 2003 , Infopedia". eresources.nlb.gov.sg. Archived from the original on 2019 ...
"Severe acute respiratory syndrome (SARS) outbreak, 2003". NLB. Archived from the original on 30 June 2019. Retrieved 15 July ... 1 March to 16 July - An outbreak of severe acute respiratory syndrome (SARS) occurs in Singapore. 1 March - The first SARS ...
"Severe Acute Respiratory Syndrome: Lessons from Singapore". Emerging Infectious Diseases. 9 (10): 1294-8. doi:10.3201/ ... Severe Acute Respiratory Disease (SARS), infection control in hospital settings especially as it relates to multi-drug- ... Among many other papers on MRSA, in 2013 he published "Sustained MRSA control in a hyper-endemic tertiary acute care hospital ... In addition, all patients with respiratory complaints or chest x-ray abnormalities would be isolated, screened for SARS ...
Schabas, Richard (2004). "Severe acute respiratory syndrome: Did quarantine help?". The Canadian Journal of Infectious Diseases ...
ICTV approved it as Severe acute respiratory syndrome coronavirus in 2004, and renamed it Severe acute respiratory syndrome- ... Zoonotic species such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome- ... "ICTV Taxonomy history: Severe acute respiratory syndrome-related coronavirus". International Committee on Taxonomy of Viruses ( ... On 2 March 2020, ICTV published the formal description and gave the official name as Severe acute respiratory syndrome-related ...
Tong, Tomy R. (2006). "Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)". In Edward Tabor (ed.). Emerging Viruses in ...
Severe acute respiratory syndrome coronavirus 2, the virus causing the 2019-2020 outbreak ...
... such as severe acute respiratory syndrome (SARS). Lactoferrin and lactoferricin inhibit in vitro growth of Trichophyton ... "Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome". BMC Immunol. 6: 2. doi:10.1186 ... Lactoferrin levels in tear fluid have been shown to decrease in dry eye diseases such as Sjögren's syndrome. A rapid, portable ... Respiratory tract antimicrobial defense system GRCh38: Ensembl release 89: ENSG00000012223 - Ensembl, May 2017 GRCm38: Ensembl ...
... a rare cause of severe acute respiratory distress syndrome". Intensive Care Medicine. 26 (2): 215-217. doi:10.1007/ ... and description of the hematologic syndrome". Am J Hematol. 46 (2): 147-50. doi:10.1002/ajh.2830460217. PMID 8172183.. ...
SARS (Severe Acute Respiratory Syndrome) SARS coronavirus Scabies Sarcoptes scabiei Scarlet fever Group A Streptococcus species ... Middle East respiratory syndrome (MERS) Middle East respiratory syndrome coronavirus Melioidosis (Whitmore's disease) ... Respiratory system/. acute viral nasopharyngitis/. viral pneumonia. DNA virus. *Epstein-Barr virus *EBV infection/Infectious ... Common cold (Acute viral rhinopharyngitis; Acute coryza) usually rhinoviruses and coronaviruses Creutzfeldt-Jakob disease (CJD ...
In this capacity she was operational lead of the response to the severe acute respiratory syndrome (SARS) and Influenza A virus ... "Identification of Severe Acute Respiratory Syndrome in Canada". New England Journal of Medicine. 348 (20): 1995-2005. doi: ... "Public Health Measures to Control the Spread of the Severe Acute Respiratory Syndrome during the Outbreak in Toronto". New ... for the general public to take special precautions beyond the usual measures recommended to prevent other common respiratory ...
6 June 2013). "Prone Positioning in Severe Acute Respiratory Distress Syndrome". New England Journal of Medicine. 368 (23): ... June 2006). "A Multicenter Trial of Prolonged Prone Ventilation in Severe Acute Respiratory Distress Syndrome". American ... August 15, 2017). "Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis". Annals of ... April 2010). "Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic ...
It causes severe acute respiratory syndrome in bats. Isolates have not been found in humans. The Miniopterus bat is a bent- ... Common bent-wing bat Murinae Severe acute respiratory syndrome (SARS) Zoonosis Chu DK, Poon LL, Chan KH, Chen H, Guan Y, Yuen ...
Inflammatory reaction (e.g. acute respiratory tract infections, chronic sinusitis, rhinitis or environmental irritants) ... Hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), a rare disease that runs in families ... Sometimes in more severe cases, the blood can come up the nasolacrimal duct and out from the eye. Fresh blood and clotted blood ...
Acute respiratory distress syndrome (ARDS), alveolar hemorrhage, and allergic reactions (usually expressed in first 30 minutes ... For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse ... and hepatic VOD has lately been referred to as sinusoidal obstruction syndrome (SOS). Severe cases of SOS are associated with a ... Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ...
"Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine". Proceedings of ... anthrax and respiratory syncytial virus.[41] Korean scientists are looking at using the tomato to express a vaccine against ...
... especially with respect to acute coronary syndrome admissions.[72][73] However, other studies came to the conclusion that ... and respiratory diseases, and that "More comprehensive laws were associated with larger changes in risk."[67] The senior author ... "Treatment protocols of the lupus nephritis collaborative study of plasmapheresis in severe lupus nephritis. The Lupus ... "significant reduction in acute MI [myocardial infarction] risk", but noted that "studies with smaller population in the United ...
Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A (May 1988). "Fatal adult respiratory distress syndrome in a ... such as diverticulitis and acute coronary syndrome.[36][106] Diagnosis of late-stage Lyme disease is often complicated by a ... severe headaches with neck stiffness, or heart palpitations, among others.[1] Months to years later, repeated episodes of joint ... Garin-Bujadoux syndrome, Bannwarth syndrome, Afzelius's disease,[255] Montauk Knee or sheep tick fever. Since 1976 the disease ...
Chronic prostatitis/chronic pelvic pain syndrome, chronic bacterial prostatitis, acute (sudden) bacterial prostatitis, and ... "Diagnosis and treatment of severe hematochezia. The role of urgent colonoscopy after purge". Gastroenterology. 95 (6): 1569- ... for the diagnosis of appendicitis or other examples of an acute abdomen (i.e. acute abdominal symptoms indicating a serious ... "We found the DRE to have a limited role in the diagnosis of acute, undifferentiated abdominal pain and acute appendicitis.";[10 ...
... pulmonya ay maaaring magdulot ng hindi paggana ng paghinga sa pamamagitan ng pagdudulot ng acute respiratory distress syndrome ... Rello, J (2008). "Demographics, guidelines, and clinical experience in severe community-acquired pneumonia". Critical care ( ... Garenne M; Ronsmans C, Campbell H (1992). "The magnitude of mortality from acute respiratory infections in children under 5 ... malubhang respiratory distress syndrome (kawalan ng kakayahan ng baga para umalsa), sepsis (impeksiyon sa dugo), at paglala ng ...
Cushing's syndrome. References[edit]. *^ a b Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 10: Neural and Neuroendocrine ... Clinical Medicine: Circulatory, Respiratory, and Pulmonary Medicine. 2: 35-44. PMC 2990232. PMID 21157520. Retrieved 14 ... Atrophy of the hippocampus in humans and animals exposed to severe stress is believed to be caused by prolonged exposure to ... Douglas AJ (March 2005). "Central noradrenergic mechanisms underlying acute stress responses of the Hypothalamo-pituitary- ...
The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ... Severe obesity: Investigating the socio-demographics within the extremes of body mass index. Obesity Research & Clinical ... The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies. CMAJ. 2006-04, 174 (9): 1293 ... 肥胖是幾個症候群的主要特徵,比如說普瑞德威利症候群(俗稱小胖威利症候群)、巴德-畢德氏症
Severe acute respiratory syndrome. *V: Orthomyxoviridae: Influenzavirus A/B/C/D *Influenza/Avian influenza ... Respiratory system/. acute viral nasopharyngitis/. viral pneumonia. DNA virus. *Epstein-Barr virus *EBV infection/Infectious ... ultimately causing severe cerebellar atrophy.[14] This syndrome, called JCV granule cell layer neuronopathy (JCV GCN), is ... Other strains and novel pathological syndromes[edit]. Although JC virus infection is classically associated with white matter ...
Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... Mortality associated with severe sepsis remains high at 30-50%. When shock is present, mortality is reported to be even higher ... Using bundles in health care simplifies the complex processes of the care of patients with severe sepsis. A bundle is a ...
Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac disease, severe acute ... They are rare in the blood, but numerous in the mucous membranes of the respiratory, digestive, and lower urinary tracts.[9] ... Immune dysfunction - arthritis, systemic lupus erythematosus, Sjögren syndrome, myasthenia gravis, systemic vasculitis, Behcet- ... Treatment is also aimed at the underlying cause of the neutropenia.[17] One severe consequence of neutropenia is that it can ...
George L. Waldbott, an American allergist, first described a new disease he named "smoker's respiratory syndrome" in the 1953 ... they decrease acute exacerbations in those with either moderate or severe disease.[143] By themselves, they have no effect on ... acute. Acute bronchitis. chronic. COPD Chronic bronchitis. Acute exacerbation of COPD). Asthma (Status asthmaticus. Aspirin- ... Palange P (2013). ERS Handbook of Respiratory Medicine. European Respiratory Society. p. 194. ISBN 978-1-84984-041-5. .. ...
2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... Severe exposure may result in changes in upper and lower airways resulting in an acute lung injury, which may not be present ... 2011) The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 6:147-63. [2] Johnson ER, Matthay ... Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ...
... and OSA is fairly common in acute cases of severe infectious mononucleosis. Temporary spells of OSA syndrome may also occur in ... "American Journal of Respiratory and Critical Care Medicine. 191 (11): 1295-1309. doi:10.1164/rccm.201501-0169OC. PMC 4476519. ... Some use the terms obstructive sleep apnea syndrome or obstructive sleep apnea-hypopnea syndrome to refer to OSA which is ... The hallmark symptom of OSA syndrome in adults is excessive daytime sleepiness. Typically, an adult or adolescent with severe ...
Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake]" [Acute ... along with unusually severe myalgia (muscle pain).[5][6][7] ... Toxic oil syndrome. References[edit]. *^ Bolton P, Lindgren CE ... The initial, acute phase of EMS, which last for three to six months, presents as trouble with breathing and muscle problems, ... Eosinophilia-myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary ...
Acute alcohol intoxication/. Alcohol intoxication Harmful use of alcohol Alcohol dependence syndrome Alcohol withdrawal ... F43) Reaction to severe stress, and adjustment disorders *(F43.0) Acute stress reaction ... Diseases of the respiratory system XI K00-K93 Diseases of the digestive system ... F23) Acute and transient psychotic disorders *(F23.0) Acute polymorphic psychotic disorder without symptoms of schizophrenia ...
Severe diseaseEdit. The standard treatment for severe GPA is to induce remission with immunosuppressants such as rituximab or ... In general, rhinitis is the first sign in most people.[11][12] Involvement of the upper respiratory tract, such as the nose and ... Granulomatosis with polyangiitis is part of a larger group of vasculitic syndromes called systemic vasculitides or necrotizing ... The use of plasmapheresis in those with GPA and acute kidney failure (renal vasculitis) reduces progression to end-stage kidney ...
Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic ... The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack ... a potential mechanism underlying adult respiratory distress syndrome". The American Journal of Pathology. 173 (4): 915-26. doi: ... Overexpression of SOD1 has been linked to the neural disorders seen in Down syndrome.[38] In patients with thalassemia, SOD ...
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bats, pangolins, felines, minks respiratory transmission 2019 ... Severe acute respiratory syndrome SARS coronavirus bats, civets close contact, respiratory droplets ... Middle East respiratory syndrome MERS coronavirus bats, camels close contact Monkeypox Monkeypox virus rodents, primates ...
Shortages of healthcare providers, poor intra-partum and newborn care, diarrheal diseases and acute respiratory infections also ... This results in a very high financial burden on families in case of severe illness. Though, the 12th plan document express ... This may be attributed to a genetic predisposition to metabolic syndrome and adverse changes in coronary artery vasodilation. ... Breast Cancer : One of the most severe and increasing problems among women in India, resulting in higher mortality rates. ...
Tourette syndrome and tics can also affect speech. Various congenital and acquired tongue diseases can affect speech as can ... Paul Broca identified an approximate region of the brain in 1861 which, when damaged in two of his patients, caused severe ... Diseases and disorders of the lungs or the vocal cords, including paralysis, respiratory infections (bronchitis), vocal fold ... which is characterized by relatively normal syntax and prosody but severe impairment in lexical access, resulting in poor ...
慢性阻塞性肺病急性發作(英语:Acute exacerbation of chronic obstructive pulmonary disease). 肺氣腫). 哮喘(急性重症哮喘(英语:Acute severe asthma). 阿司匹林誘發哮喘( ... 類風濕塵肺綜合症(英语:Caplan's syndrome). 石末肺(英语:Chalicosis). 煤礦工人肺塵病(英语:Coalworker's pneumoconiosis). 鐵肺病(英语:Siderosis). 矽肺病. 滑石肺(英语: ... 呼吸系統病理學(J,460-519(英语:List of ICD-9 codes 460-519: diseases
Severe radiologic signs (pneumoperitoneum). *Additional laboratory changes (metabolic and respiratory acidosis, disseminated ... Some children may suffer from short bowel syndrome if extensive portions of the bowel had to be removed. ... A Cochrane review in 2014 found that supplementation of probiotics enterally "prevents severe NEC as well as all-cause ... Complications may include short-gut syndrome, intestinal strictures, or developmental delay.[2] ...
Examples include flail arm syndrome, flail leg syndrome, and isolated bulbar ALS. Flail arm syndrome and flail leg syndrome are ... Respiratory onset[edit]. Respiratory-onset ALS is a rare variant that accounts for about 3% of all cases of ALS,[11] in which ... A 2015 review found that moderate to severe traumatic brain injury is a risk factor for ALS, but whether mild traumatic brain ... Additional names for flail arm syndrome include the scapulohumeral form of ALS, Vulpian-Bernart syndrome, hanging arm syndrome ...
While there is a proven correlation between mold exposure and the development of upper and lower respiratory syndromes, there ... The lawsuit asserted that a child in the home suffered from severe respiratory problems for several years as a result of the ... August 1998). "Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi". Arch ... Other problems are respiratory and/or immune system responses including respiratory symptoms, respiratory infections, ...
"The species Severe acute respiratory syndrome related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2" (PDF). ...
Acute side effects[edit]. Nausea and vomiting. This is not a general side effect of radiation therapy, and mechanistically is ... If the head and neck area is treated, temporary soreness and ulceration commonly occur in the mouth and throat.[12] If severe, ... The reaction may become more severe during the treatment and for up to about one week following the end of radiation therapy, ... Lee VH, Ng SC, Leung TW, Au GK, Kwong DL (2012). "Dosimetric predictors of radiation-induced acute nausea and vomiting in IMRT ...
Hypopnea syndrome, abnormally shallow breathing or slow respiratory rate while sleeping.. *Idiopathic hypersomnia, a primary, ... Not a disorder unless severe. Often seen as part of narcolepsy.. *Sleepwalking or somnambulism, engaging in activities normally ... In one particular study, participants (18 years or older) who had experienced acute or chronic sleep disorders were put in a ... Restless Leg Syndrome[edit]. According to one meta-analysis, the mean prevalence rate for North America and Western Europe is ...
Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a coronavirus called SARS-associated ... A select agent is a bacterium, virus or toxin that has the potential to pose a severe threat to public health and safety. ... Content source: National Center for Immunization and Respiratory Diseases, Division of Viral Diseases ...
Severe Acute Respiratory Syndrome - Press briefing 25 March 2003. Severe Acute Respiratory Syndrome - Press briefing 21 March ... Severe Acute Respiratory Syndrome - Press briefing 2 April 2003. Severe Acute Respiratory Syndrome - Press briefing 1 April ... Severe Acute Respiratory Syndrome - Press briefing, Beijing, China. 28 March 2003. Severe Acute Respiratory Syndrome - Press ... Severe Acute Respiratory Syndrome - Virtual Press Briefing. 23 April 2003. Severe Acute Respiratory Syndrome - Teleconference ...
... On April 22, 2003, the Taiwan Department of Health (DOH) was notified of ... Severe acute respiratory syndrome---Singapore, 2003. MMWR 2003;52:405--11. * Booth CM, Matukas LM, Tomlinson GA, et al. ... Control measures for severe acute respiratory syndrome (SARS) in Taiwan. Emerg Infect Dis 2003. Available at http://www.cdc.gov ... seven cases of severe acute respiratory syndrome (SARS) among health-care workers (HCWs) at a large municipal hospital in ...
Severe acute respiratory syndrome is an infectious disease in humans that was first recognised in south east Asia in late ... Severe acute respiratory syndrome revisited Coronavirus may be responsible, but new information arrives every day ... Severe acute respiratory syndrome revisited. BMJ 2003; 326 doi: https://doi.org/10.1136/bmj.326.7394.831 (Published 19 April ... Enteric, Respiratory and Neurological Virus Laboratory, Health Protection Agency, London NW9 5HT. ...
2003)‎. Severe acute respiratory syndrome (‎SARS)‎. World Health Organization. https://apps.who.int/iris/handle/10665/78337 ... Protocol for the investigation of acute respiratory illness outbreaks of unknown etiology  ...
Infection with the SARS virus causes acute respiratory distress (severe breathing difficulty), and sometimes death. ... Severe acute respiratory syndrome (SARS) is a serious form of pneumonia. ... Severe acute respiratory syndrome (SARS) is a serious form of pneumonia. Infection with the SARS virus causes acute respiratory ... Perlman S, McIntosh K. Coronaviruses, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome ( ...
Mechanically ventilated patients with COVID-19 can be managed like patients with acute respiratory distress syndrome, according ... Cite this: Severe COVID-19 Resembles Acute Respiratory Distress Syndrome - Medscape - May 08, 2020. ... Mechanically ventilated patients with COVID-19 can be managed like patients with acute respiratory distress syndrome (ARDS), ... Some reports have suggested that a significant proportion of COVID-19 respiratory failure is not the typical ARDS and warrants ...
Severe Acute Respiratory Syndrome-associated Coronavirus Disease (SARS-CoV) , 2003 Case Definition Revised Jul 1, 2003 (https ... Severe Acute Respiratory Syndrome-associated Coronavirus Disease * 2003 Case Definition Revised Jul 1, 2003 ... wwwn.cdc.gov/nndss/conditions/severe-acute-respiratory-syndrome-associated-coronavirus-disease/case-definition/2003/07/) ...
Severe acute respiratory syndrome (SARS) is a respiratory disease caused by the SARS-associated coronavirus (SARS-CoV). ... Coronaviruses are a large family of viruses that cause illness in humans, ranging from the common cold to severe respiratory ... Both viruses are coronaviruses and both can cause severe respiratory disease. MERS-CoV, however, does not appear to spread as ... People should follow these tips to help prevent respiratory illnesses of any kind:. *Wash your hands often with soap and water ...
... Ver/. Abrir. Prevention and Control of Severe Acute ... 2003)‎. Prevention and Control of Severe Acute Respiratory Syndrome (‎SARS)‎.. New Delhi: WHO Regional Office for South-East ...
Symptoms are like any other respiratory illnesses or flu such as dry coughing, fever and breathing problems. ... Severe acute respiratory syndrome (SARS) is the result of coronavirus. ... Treating Tips For Acute Respiratory Distress Syndrome (ARDS). Adult respiratory distress syndrome is also known as acute ... Understand that SARS, which first hit around the year 2002, is Severe acute respiratory syndrome, which is the result of a kind ...
Severe Acute Respiratory Syndrome. SARS: Overview. SARS (Severe Acute Respiratory Syndrome) is a viral respiratory disease. ... SARS- Severe Acute Respiratory Syndrome. ROMERO HOUSE. SARS: Overview. During its 2003 outbreak, SARS infected upwards of 8500 ... A select agent is a bacterium, virus or toxin that has the potential to pose a severe threat to public health and safety. - ... SARS- Severe Acute Respiratory Syndrome. No description by Sean S. on 11 November 2015 ...
Severe Acute Respiratory Syndrome (SARS) is a respiratory infection that was first identified in a 2003 outbreak. ... Severe Acute Respiratory Syndrome (SARS) is a respiratory infection that was first identified in a 2003 outbreak. ... Severe acute respiratory syndrome. American Lung Association website. Available at: http://www.lung.org/lung-disease/severe- ... acute-respiratory-syndrome. Accessed December 22, 2014.. Severe acute respiratory syndrome (SARS). Centers for Disease Control ...
SARS is caused by a type of coronavirus, which can cause mild to moderate upper respiratory illness, such as the common cold. ... is a respiratory illness that first infected people in parts of Asia, North America, and Europe in late 2002 and early 2003. ... Severe Acute Respiratory Syndrome (SARS). Topic Overview. What is SARS?. Severe acute respiratory syndrome (SARS) is a ... 2003). The severe acute respiratory syndrome. New England Journal of Medicine, 349(25): 2431-2441. ...
Insciences is a non-profit organization based in Switzerland and hosted by nextron. Insciences is an international, free-access sciences news website dedicated solely to experts in science fields such as researchers, professors, doctors, lecturers and PhD students from all around the world.. ...
An outbreak of severe acute respiratory syndrome (SARS) has recently been reported from Hong Kong.1 A novel coronavirus has ... Identification of severe acute respiratory syndrome in Canada. N Engl J Med 2003; 348: 1995-2005. ... A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003; 348: 1986-94. ... A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-66. ...
Stories about Severe acute respiratory syndrome coronavirus 2. Follow. Subscribe to Severe acute respiratory syndrome ...
encoded search term (Severe Acute Respiratory Syndrome (SARS)) and Severe Acute Respiratory Syndrome (SARS) What to Read Next ... Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome. JAMA. 2003 Jul 16. 290(3 ... Severe Acute Respiratory Syndrome (SARS) Treatment & Management. Updated: Mar 13, 2019 * Author: David J Cennimo, MD, FAAP, ... Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax. 2004 May. 59(5):414-20. [ ...
... on clinical features and treatment for patients with Severe Acute Respiratory Syndrome (SARS) (1). Their discussion, organised ... Clinical descriptions of Severe Acute Respiratory Syndrome (SARS). Euro Surveill. 2003;7(13):pii=2194. https://doi.org/10.2807/ ... Clinical descriptions of Severe Acute Respiratory Syndrome (SARS) * Eurosurveillance editorial team * * View Citation Hide ...
Acute respiratory distress syndrome, OR. *Autopsy findings consistent with pneumonia or acute respiratory distress syndrome ... Severe Acute Respiratory Syndrome-associated Coronavirus Disease (SARS-CoV). 2003 Case Definition Revised Jul 1, 2003 ... Severe Acute Respiratory Syndrome-associated Coronavirus Disease * 2003 Case Definition Revised Jul 1, 2003 ... 2003). Revised U.S. Surveillance Case Definition for Severe Acute Respiratory Syndrome (SARS) and Update on SARS Cases - United ...
Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its ... Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Clin Exp Immunol. 2004 Apr;136(1):95-103. doi ... Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its ... Severe Acute Respiratory Syndrome / blood* * Severe Acute Respiratory Syndrome / drug therapy * T-Lymphocytes, Helper-Inducer ...
... ». Joi. Mar 16, 2003 - 05:07 UTC » Categories:. *Health and Medicine ... Joi Ito - "Severe Acute Respiratory Syndrome (SARS) Spreads Worldwide" by Joi Ito is licensed under a Creative Commons ... Severe Acute Respiratory Syndrome (SARS) Spreads Worldwide. ----------------------. 15 March 2003 , GENEVA -- During the past ... WHO has received reports of more than 150 new suspected cases of Severe Acute Respiratory Syndrome (SARS), an atypical ...
... the family of viruses that causes the common cold SARS is a rapidly progressive respiratory illness that is spread from person ... Learn About Severe Acute Respiratory Syndrome (SARS). Severe acute respiratory syndrome (SARS) is an infectious condition that ... Severe Acute Respiratory Syndrome (SARS) *Learn About Severe Acute Respiratory Syndrome (SARS) ... www.lung.org > Lung Health and Diseases > Lung Disease Lookup > Severe Acute Respiratory Syndrome (SARS) ...
WHO had named this disease as Severe Acute Respiratory Syndrome, also known as SARS. ... sore throat and acute respiratory distress syndrome. Four days later, he died after his condition deteriorating and many of the ... of breath.It should be severe enough to hospitalization and chest X-ray changes show pneumonia or respiratory distress syndrome ... Large respiratory droplets and direct or indirect contact with bodily fluids are the most important routes of transmission from ...
Severe acute respiratory syndrome (SARS) is a life-threatening respiratory disease that probably originated in Guangdong ... Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Boyd Yount, Kristopher M ... Abbreviations: CoV, coronavirus; SARS, severe acute respiratory syndrome; icSARS, infectious clone SARS; E64-d, (2S,3S)- ... A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). ...
Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/WA-... Severe acute respiratory syndrome ... Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/WA-UW-6327/2020, complete genome. GenBank: ...
Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/MN-... Severe acute respiratory syndrome ... Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/MN-CDC-6566/2020, complete genome. GenBank: ...
... Mena Alrais Dellarocca, PharmD, RPh. Adjunct Instructor ... ABSTRACT: At the end of 2019, a novel coronavirus now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was ... Of over 6.8 million doses administered nationally, there have been six reported cases of a rare and severe type of blood clot ... were reported as severe, with severe solicited adverse reactions being more frequent after dose 2 than after dose 1 and ...
  • NEW YORK (Reuters Health) - Mechanically ventilated patients with COVID-19 can be managed like patients with acute respiratory distress syndrome (ARDS), according to a new report. (medscape.com)
  • Cite this: Severe COVID-19 Resembles Acute Respiratory Distress Syndrome - Medscape - May 08, 2020. (medscape.com)
  • Adult respiratory distress syndrome is also known as acute respiratory distress syndrome. (home-remedies-for-you.com)
  • On February 26 of the same year, an American businessman in Vietnam was hospitalized because of fever, dry cough, muscle ache, sore throat and acute respiratory distress syndrome. (gov.tw)
  • The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). (clinicaltrials.gov)
  • This international multicenter, randomized, open trial will evaluate the impact of Extracorporeal Membrane Oxygenation (ECMO), instituted early after the diagnosis of acute respiratory distress syndrome (ARDS) not evolving favorably after 3-6 hours under optimal ventilatory management and maximum medical treatment, on the morbidity and mortality associated with this disease. (clinicaltrials.gov)
  • A severe blow to the concept of venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome in the form of a well-executed randomized controlled trial. (ctsnet.org)
  • For a case to be considered probable, a chest X-ray must be indicative for atypical pneumonia or acute respiratory distress syndrome. (wikipedia.org)
  • Pneumonia or Acute Respiratory Distress Syndrome (ARDS) which lead to fatalities. (myhealth.gov.my)
  • It is well known that survivors of severe illness associated with lung injury, such as acute respiratory distress syndrome (ARDS), have persistent morbidity from lung function impairment 2 . (ersjournals.com)
  • Hafiz Mahboob, Robert Richeson III, and Robert McCain, "Zinc Chloride Smoke Inhalation Induced Severe Acute Respiratory Distress Syndrome: First Survival in the United States with Extended Duration (Five Weeks) Therapy with High Dose Corticosteroids in Combination with Lung Protective Ventilation," Case Reports in Critical Care , vol. 2017, Article ID 7952782, 8 pages, 2017. (hindawi.com)
  • As the disease progresses, about 20 percent to 30 percent of patients develop pneumonia or acute respiratory distress syndrome and require hospitalization. (nyhq.org)
  • Smoke induced severe acute respiratory distress syndrome (ARDS) is often fatal and there are no standard treatment guidelines. (americanelements.com)
  • For patients with severe acute respiratory distress syndrome from COVID-19, how do you prevent delirium when you cannot provide a sedation vacation or spontaneous breathing trial? (sccm.org)
  • 8, 9 In those patients who deteriorate, the radiological changes progress to bilateral involvement and resemble adult respiratory distress syndrome. (bmj.com)
  • Objectives A recent update of the definition of acute respiratory distress syndrome (ARDS) proposed an empirical classification based on ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO 2 /FiO 2 ) at ARDS onset. (bmj.com)
  • A person was classified as under investigation as a probable case if they met the criteria to be under investigation as a suspect case and had evidence of pneumonia by chest x-ray or acute respiratory distress syndrome or was positive for SARS coronavirus by one or more assays. (cancerscreening.gov.au)
  • 50 years) and those with cardiac and respiratory disorder, it may progress to pneumonia, acute respiratory distress syndrome, and multi organ failure. (physiciansweekly.com)
  • Distinct alterations in inflammation were present in TRIF −/− mice infected with SARS-CoV, including excess infiltration of neutrophils and inflammatory cell types that correlate with increased pathology of other known causes of acute respiratory distress syndrome (ARDS), including influenza virus infections. (asm.org)
  • In our paper, we use detailed patient-level data to show that oxygenation and lung mechanics in our patients with COVID-19 respiratory failure exist on a spectrum, are squarely consistent with 'typical' ARDS, and respond as expected to standard therapies, including prone ventilation," Dr. Jehan Alladina of Massachusetts General Hospital, in Boston, told Reuters Health by email. (medscape.com)
  • Some reports have suggested that a significant proportion of COVID-19 respiratory failure is not the typical ARDS and warrants alternative management. (medscape.com)
  • Of these patients, 56 (85%) met Berlin criteria for ARDS, with most having mild to moderate ARDS, the authors report in the American Journal of Respiratory and Critical Care Medicine. (medscape.com)
  • 38 plus indications of lower respiratory tract infection (cough, dyspnea) Severe Illness: ≥1 of radiographic evidence, presence of ARDS, autopsy findings in late patients. (wikipedia.org)
  • Mortality and ventilator-free days: there is medium-quality evidence that mechanical ventilation utilising a low tidal volume of 6 mL/kg of predicted body weight in patients with acute lung injury (ALI) or ARDS seems to be more effective compared with conventional or high tidal-volume mechanical ventilation at reducing duration of ventilation and mortality in the longer term. (bmj.com)
  • Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction associated with septic shock. (clinicaltrials.gov)
  • Whether hydrocortisone can effectively prevent disease progression and death in severe sepsis/septic shock patients who complicated with ALI/ARDS has not been proven. (clinicaltrials.gov)
  • We report the first survival of smoke induced severe ARDS in the United States (US) with prolonged use of high dose steroids (five weeks) and lung protective ventilation alone. (americanelements.com)
  • PaO 2 /FiO 2 ≤200) and severe (PaO 2 /FiO 2 ≤100) ARDS and followed until hospital discharge. (bmj.com)
  • Results At ARDS onset, 173 patients had a PaO 2 /FiO 2 ≤100 but only 38.7% met criteria for severe ARDS at 24 h under SVS. (bmj.com)
  • Repeated daily trials in the prone position should be considered in the management of ARDS patients with severe hypoxemia. (ovid.com)
  • have outlined an important limitation of our study, although the indication for EWO was unquestionnable-severe ARDS with lung hyperdensities involving 50% of the lung parenchyma, low respiratory compliance, and profound hypercarbia with acid-base compromise resulting in increased pulmonary artery pressure [3] -the technical conditions of EWO administration were not optimized. (asahq.org)
  • that our study should not bias intensivists against the use of EWO in patients with severe ARDS. (asahq.org)
  • Unsuspecting hospital workers admitted the Hong Kong man infected by Jianlun to a general ward at the Prince of Wales Hospital because it was assumed he had a typical severe pneumonia - a fairly routine admission. (encyclopedia.com)
  • Severe acute respiratory syndrome (SARS) is a serious form of pneumonia . (medlineplus.gov)
  • GENEVA -- During the past week, WHO has received reports of more than 150 new suspected cases of Severe Acute Respiratory Syndrome (SARS), an atypical pneumonia for which cause has not yet been determined. (ito.com)
  • ABSTRACT: At the end of 2019, a novel coronavirus now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases in Wuhan, China. (uspharmacist.com)
  • Some days later, pneumonia becomes manifest, which in some cases progresses to produce fatal respiratory failure (overall death rate has been about 10%, but exceeded 50% for patients aged over 60 years). (europa.eu)
  • It causes an often severe illness and is marked initially by systemic symptoms of muscle pain, headache, and fever, followed in 2-14 days by the onset of respiratory symptoms, mainly cough, dyspnea, and pneumonia. (wikipedia.org)
  • Severe acute respiratory syndrome (SARS) is a potentially fatal type of pneumonia caused by an unidentified organism. (vic.gov.au)
  • Severe acute respiratory syndrome (SARS) is a type of pneumonia, or infection of the lungs, that can cause illness or death. (vic.gov.au)
  • Early cases of SARS appeared to have originated in southern China (Guangdong province) as an unusual epidemic of severe pneumonia in November 2002. (bmj.com)
  • Several hundred cases of severe atypical pneumonia of unknown etiology were reported in Guangdong Province of the People's Republic of China beginning in late 2002. (sciencemag.org)
  • It is a severe pneumonia-like (i.e. lung) disease. (pharmasave.com)
  • It is a severe pneumonia-like respiratory disease first seen in Southeast Asia in late February 2003 that spreads through close contact with an infected person. (pharmasave.com)
  • The severe acute respiratory syndrome (SARS) coronavirus (CoV) was identified as the etiological agent of an acute respiratory disease causing atypical pneumonia and diarrhea with high mortality. (csic.es)
  • If you develop severe pneumonia, you might need to go to hospital and have artificial ventilation in an intensive care unit. (healthdirect.gov.au)
  • On 12 March 2003, the World Health Organization (WHO) issued a global alert about cases of a new, highly infectious severe atypical pneumonia referred to as severe acute respiratory syndrome (SARS). (cancerscreening.gov.au)
  • Unaware of the problems in China, Urbani's report drew increased attention among epidemiologists when coupled with news reports in mid-March that Hong Kong health officials had also discovered an outbreak of an acute respiratory syndrome among health care workers. (encyclopedia.com)
  • Severe Acute Respiratory Syndrome (SARS) is a respiratory infection that was first identified in a 2003 outbreak. (denverhealth.org)
  • An outbreak of severe acute respiratory syndrome (SARS) has recently been reported from Hong Kong. (bmj.com)
  • 800 deaths ( www.who.int/csr/sars/en ) before aggressive infection control measures successfully contained the scope of the outbreak. (pnas.org)
  • An outbreak of severe acute respiratory syndrome (SARS) began in Canada in February 2003. (cmaj.ca)
  • Barboza P , Quatresous I . Severe Acute Respiratory Syndrome (SARS) - update on the international outbreak, 8 April 2003. (eurosurveillance.org)
  • The situation of the international outbreak of Severe Acute Respiratory Syndrome (SARS) was summarized by the International Department at the Institut de veille sanitaire in France as of 1900 hours Central European time, 8 April 2003, as follows. (eurosurveillance.org)
  • The syndrome caused the 2002-2004 SARS outbreak. (wikipedia.org)
  • Epidemiological data from the 2002-2003 SARS epidemic and recent Middle East respiratory syndrome outbreak indicate that there may be sex-dependent differences in disease outcomes. (jimmunol.org)
  • http://www.who.int/csr/sars/country/table2004_04_21/en/ Most of what is known about the disease has been provided by this 2003 outbreak. (bmj.com)
  • The summary below is from the full report titled An Outbreak of Severe Acute Respiratory Syndrome among Hospital Workers in a Community Hospital in Hong Kong. (annals.org)
  • A 43 year old woman, working as a health care assistant in a medical ward designated for the care of severe acute respiratory syndrome (SARS) patients during the outbreak in 2003, was admitted because of fever, dry cough, diarrhoea, chills, and rigor for two days. (bmj.com)
  • There were some hospitals that quickly ran out of respirators, of oxygen and available medical expertise, and the increased availability of critical medical supplies needs to be kept in mind with an outbreak of respiratory infections. (psychiatryadvisor.com)
  • The outbreak of severe acute respiratory syndrome (SARS), 3 an acute and highly contagious pulmonary illness that spreads primarily via the respiratory route, has had a devastating social, economic, and medical impact worldwide ( 1 ). (jimmunol.org)
  • Human coronavirus infections typically cause only mild or moderate diseases ( 19 , 43 ), so the revelation that the newly identified severe acute respiratory syndrome (SARS) coronavirus (SCoV) is the etiologic agent for the global outbreak of life-threatening SARS in the winter of 2002/2003 was surprising ( 7 , 17 , 18 , 34 ). (asm.org)
  • The conference discussed lessons learned since the 2003 Severe Acute Respiratory Syndrome outbreak, and such recent events as the appearance in Saudi Arabia of the MERS-coronavirus . (hku.hk)
  • IMPORTANCE Bats (order Chiroptera, suborders Megachiroptera and Microchiroptera) are reservoirs for a wide range of viruses that cause diseases in humans and livestock, including the severe acute respiratory syndrome coronavirus (SARS-CoV), responsible for the global SARS outbreak in 2003. (asm.org)
  • The outbreak of severe acute respiratory syndrome (SARS) in Toronto and other cities in 2003 showed a heightened sensitivity of places in the global economy to rapid changes brought on by the acceleration of social and ecological relationships. (repec.org)
  • SARS-CoV is most easily spread from person to person through close contact with an infected person, particularly through respiratory droplets produced when a person coughs or sneezes. (virginia.gov)
  • Like most respiratory illnesses, SARS is spread mainly through contact with infected saliva or droplets from coughing. (cigna.com)
  • SARS is highly contagious and is transmitted by respiratory droplets or contact with other bodily fluids. (lung.org)
  • The primary route of transmission for SARS-CoV is contact of the mucous membranes with respiratory droplets or fomites. (wikipedia.org)
  • Keeping children with symptoms home from school Simple hygiene measures Isolating oneself as much as possible to minimize the chances of transmission of the virus Many public health interventions were made to try to control the spread of the disease, which is mainly spread through respiratory droplets in the air, either inhaled or deposited on surfaces and subsequently transferred to a body's mucous membranes. (wikipedia.org)
  • SARS is spread by close person-to-person contact, most readily by respiratory droplets. (who.int)
  • When a person with SARS coughs or sneezes without covering his or her mouth, respiratory droplets containing living virus can spray up to 3 feet and invade the mucous membranes of another person. (nyhq.org)
  • The virus that causes SARS is thought to be transmitted most readily by respiratory droplets, in the air or on surfaces, produced when an infected person coughs or sneezes. (nc.gov)
  • Infection with the SARS virus causes acute respiratory distress (severe breathing difficulty), and sometimes death. (medlineplus.gov)
  • On February 21 of 2003, a nephrologist in Canton had the symptom of respiration infection and died of respiratory failure. (gov.tw)
  • SARS-CoV infection is associated with overall case fatality rates thought to approach ≈14-15%, with selected populations being at increased risk ( www.who.int/csr/sars/archive/2003_05_07a/en ). (pnas.org)
  • Since February 2003 the world has been hit by a highly contagious respiratory infection which frequently results in rapidly progressive respiratory failure. (bmj.com)
  • With increasing recognition of this unusual infection, the US Centers for Disease Control and Prevention termed the condition "severe acute respiratory syndrome" (SARS). (bmj.com)
  • His symptoms of a respiratory tract infection had apparently started almost 1 week before his arrival in Hong Kong. (bmj.com)
  • Severe Acute Respiratory Syndrome is also known as severe acute respiratory syndrome, sars, sars-cov infection. (novusbio.com)
  • A Saudi man and a child have died from the MERS virus, bringing the number of deaths from the respiratory infection in the kingdom to 38, the health ministry said on Sunday. (medicalxpress.com)
  • To investigate the relationship between maximal exercise capacity measured before severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hospitalization due to coronavirus disease 2019 (COVID-19). (medworm.com)
  • After being epidemic in China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection has rapidly spread in many countries as a global pandemic, with the number of affected cases dramatically increasing worldwide on a daily basis. (medworm.com)
  • Severe acute respiratory syndrome (SARS) is an acute respiratory illness caused by infection with a new coronavirus (SARS-CoV) 1 . (ersjournals.com)
  • Much of what has been learned about SARS, including its causation and clinical manifestations, has been derived from studies done and observations made during the acute infection. (ersjournals.com)
  • How have lessons learned from the severe acute respiratory syndrome and H1N1 pandemics impacted infection control? (psychiatryadvisor.com)
  • There is always uncertainty initially about optimal infection control measures to implement, since the virulence, case reproduction rate, and transmission characteristics of the new respiratory agent are unclear. (psychiatryadvisor.com)
  • What are the conclusions from clinical trials or meta-analyses regarding severe acute respiratory syndrome and H1N1 that guide infection control practice and policies? (psychiatryadvisor.com)
  • 20 Today and starting in 2019, a severe infection associated with a coronavirus, COVID‑19, has emerged. (dentalcare.com)
  • 21 Infection with SARS‑CoV‑2 primarily causes respiratory illness ranging from mild disease to severe disease and death, and some people infected with the virus never develop symptoms. (dentalcare.com)
  • Symptoms are much like other respiratory illnesses or flu symptoms such as dry coughing, fever (look for one that is above 100.4 F) and problems breathing. (home-remedies-for-you.com)
  • 38°C), a chest radiograph or a computed tomographic image of the thorax showing evidence of consolidation with or without respiratory symptoms, and a history of close contact with a person in whom SARS had been diagnosed. (bmj.com)
  • [ 62 , 63 ] However, the outcome of the subgroup that received lopinavir/ritonavir as rescue therapy after receiving pulsed methylprednisolone treatment for worsening respiratory symptoms was not better than that for the matched cohort. (medscape.com)
  • Respiratory symptoms including a dry cough and increasing shortness of breath, developing within 2 to 7 days. (lung.org)
  • He developed progressive respiratory symptoms and bilateral pulmonary infiltrates during the second week of his illness. (hkmj.org)
  • Some people had mild respiratory symptoms at the outset. (nc.gov)
  • Severe acute respiratory syndrome is an infectious disease in humans that was first recognised in south east Asia in late February 2003. (bmj.com)
  • Severe acute respiratory syndrome (SARS) is the first emergent and highly transmissible viral disease to appear during the twenty-first century. (encyclopedia.com)
  • Both viruses are coronaviruses and both can cause severe respiratory disease. (virginia.gov)
  • SARS (Severe Acute Respiratory Syndrome) is a viral respiratory disease. (prezi.com)
  • Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. (nih.gov)
  • WHO had named this disease as Severe Acute Respiratory Syndrome, also known as SARS. (gov.tw)
  • Severe acute respiratory syndrome (SARS) is a life-threatening respiratory disease that probably originated in Guangdong Province, China, in the fall of 2002 ( 1 , 2 ). (pnas.org)
  • They have not been compared directly, but they are all highly effective and have been shown to reduce the risk of COVID-19, especially severe/critical disease. (uspharmacist.com)
  • However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). (unboundmedicine.com)
  • Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), the first identified strain of the SARS coronavirus species severe acute respiratory syndrome-related coronavirus (SARSr-CoV). (wikipedia.org)
  • Transmission of SARS-CoV occurs mainly during the second week of illness which corresponds to the peak of virus excretion in respiratory secretions and stool and when cases with severe disease start to deteriorate clinically. (myhealth.gov.my)
  • The first cases of disease in humans are believed to have occurred in Guangdong province, China, in November 2002, but the syndrome was only recognised three months later. (europa.eu)
  • Authors: Yepes-Pérez AF, Herrera-Calderon O, Sánchez-Aparicio JE, Tiessler-Sala L, Maréchal JD, Cardona-G W Abstract COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. (medworm.com)
  • Severe acute respiratory syndrome (SARS) is an emerging infectious disease with both pulmonary and extra-pulmonary manifestations. (bmj.com)
  • Severe acute respiratory syndrome (SARS) caused by a novel human coronavirus (CoV), designated SARS-CoV, is a highly contagious respiratory disease with the lungs as a major target. (jimmunol.org)
  • SARS is a highly contagious and life-threatening respiratory disease with the lower respiratory tract (e.g., the lungs) as its main target of the pathogenic process ( 3 , 8 , 9 ). (jimmunol.org)
  • Immunopathological examination of postmortem lung tissues from SARS patients revealed diffuse alveolar damage with prominent pneumocytic hyperplasia and accumulation of alveolar and interstitial macrophages (Mφ), as well as other pathological manifestations characteristic of acute respiratory disease syndrome resulting from massive inflammatory responses in the lungs. (jimmunol.org)
  • Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters. (umassmed.edu)
  • Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. (umassmed.edu)
  • Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19 (COVID-19) is a worldwide emerging situation, which was initially reported in December 2019 in Wuhan, China. (wjgnet.com)
  • Severe acute respiratory syndrome is a new disease that is highly contagious and is spreading in the local community and worldwide. (hkmj.org)
  • This new human emergent infectious disease is dominated by severe lower respiratory illness and is aetiologically linked to a new coronavirus (SARS-CoV). (bmj.com)
  • 1 The disease represents a new human emergent infectious disease dominated by severe lower respiratory tract illness. (bmj.com)
  • The method by which surveillance for SARS was rapidly established provided an opportunity to examine Australia's planning and preparedness for future respiratory disease epidemics such as influenza. (cancerscreening.gov.au)
  • The emergence and rapid spread of novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a potentially fatal disease is swiftly evolving public health crises worldwide. (physiciansweekly.com)
  • The novel coronavirus has thus been named 'severe acute respiratory syndrome coronavirus 2' (SARS-CoV-2), while coronavirus disease associated with it is now referred to as COVID-19. (europa.eu)
  • During the next few days, the patient had progressive respiratory failure and was intubated on April 22. (cdc.gov)
  • Death from progressive respiratory failure occurs in about 3% to nearly 10% of cases ( 1 - 4 ). (sciencemag.org)
  • SARS is suspected if the person has a high fever, one or more respiratory problems (such as shortness of breath), and has either been in contact with someone diagnosed with SARS or else has travelled to an area with known cases of SARS in the last two weeks. (vic.gov.au)
  • However, two-thirds have persistent fever, increasing shortness of breath, worsening of respiratory problems, and the onset of diarrhea. (nyhq.org)
  • Epidemiologists subsequently determined that, Jianlun passed on the SARS virus to other guests at the Metropole Hotel where he stayed - including an American businessman en route to Hanoi , three women from Singapore , two Canadians, and a Hong Kong resident. (encyclopedia.com)
  • Hundreds of people in Vietnam, Hong Kong and China have been stricken by a mysterious respiratory illness that has killed at least six people and left all the others with severe breathing difficulties from which they have yet to fully recover, worried officials of the World Health Organization said today. (ito.com)
  • A cluster of cases of severe acute respiratory syndrome in Hong Kong. (bmj.com)
  • Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. (bmj.com)
  • After similar cases were detected in patients in Hong Kong, Vietnam, and Canada during February and March 2003, the World Health Organization (WHO) issued a global alert for the illness, designated "severe acute respiratory syndrome" (SARS). (sciencemag.org)
  • In mid-March 2003, SARS was recognized in health care workers and household members who had cared for patients with severe respiratory illness in Hong Kong and Vietnam. (sciencemag.org)
  • A two-and-a-half-day conference sponsored by the JMSC kicked off Wednesday at Hong Kong University to mark the tenth anniversary of the Severe Acute Respiratory Syndrome (SARS) pandemic. (hku.hk)
  • Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a coronavirus called SARS-associated coronavirus (SARS-CoV). (cdc.gov)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavi. (nih.gov)
  • SARS-CoV was detected in nasopharyngeal swabs in 33 (32.4%) of 102 patients, in stool specimens in 19 (63.3%) of 30 patients, and in specimens from the lower respiratory tract in 10 (58.8%) of 17 patients. (cmaj.ca)
  • Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. (unboundmedicine.com)
  • Both SARS-CoV and MERS-CoV may cause severe respiratory failure and extrapulmonary features such as diarrhoea, whereas mild or asymptomatic cases also occur in both conditions. (nih.gov)
  • In December 2019, another strain of SARS-CoV was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (wikipedia.org)
  • Severe acute respiratory syndrome (SARS) has been documented to be caused by a novel coronavirus (SARS-CoV) 1 - 3 , which satisfied the Koch's postulations for causation 4 , 5 . (ersjournals.com)
  • Severe Acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1) is a strain of virus that causes severe acute respiratory syndrome (SARS). (wikipedia.org)
  • This virus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative pathogen of the ongoing COVID-19 pandemic. (wikipedia.org)
  • Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome-CoV, cause acute respiratory illness. (jimmunol.org)
  • Pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV and newly identified SARS- and MERS-like CoVs pose a significant threat to public health ( 1 - 7 ). (jimmunol.org)
  • SARS-CoV and MERS-CoV infect airway and alveolar epithelial cells and cause acute respiratory illnesses ( 8 , 9 ). (jimmunol.org)
  • In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). (sciencemag.org)
  • SARS-CoV RNA has frequently been detected in respiratory specimens, and convalescent-phase serum specimens from SARS patients contain antibodies that react with SARS-CoV. (sciencemag.org)
  • The case offers proof that 'SARS-CoV-2 can also infect ocular tissues in addition to the respiratory system,' the doctors reported in the Oct. 8 online edition of the journal JAMA Ophthalmology. (medworm.com)
  • 3V3M: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor. (rcsb.org)
  • The severe acute respiratory syndrome coronavirus (SARS-CoV) encodes proteins required for RNA transcription and genome replication as large polyproteins that are proteolytically processed by virus-encoded proteinases to produce mature replicase proteins. (asm.org)
  • The etiologic agent of severe acute respiratory syndrome (SARS) has been shown to be a new human coronavirus (SARS-CoV) ( 18 , 21 , 23 , 25 ). (asm.org)
  • The 3'proximal one-third of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes the structural proteins and eight accessory proteins, including 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b, varying in length from 39 to 274. (csic.es)
  • SARS‑CoV‑2 is a zoonotic human coronavirus (CoV) closely related to those coronaviruses that previously caused severe acute respiratory syndrome (SARS‑CoV) and Middle East respiratory syndrome (MERS‑CoV). (dentalcare.com)
  • Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A global pandemic and treatments strategies. (physiciansweekly.com)
  • Diagnosis of SARS-CoV-2 is recommended in respiratory secretions by special molecular tests like PCR, chest scan and common laboratory diagnosis. (physiciansweekly.com)
  • A new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged to cause a human pandemic. (eur.nl)
  • Using serum samples from patients with PCR-confirmed SARS-CoV-2 infections, other coronaviruses, or other respiratory pathogenic infections, we validated and tested various antigens in different in-house and commercial ELISAs. (eur.nl)
  • The emergence of highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) is a concern for global public health, as there is a lack of efficacious vaccine platforms and antiviral therapeutic strategies. (asm.org)
  • Search, find, compare suppliers for anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Nucleocapsid Protein antibody, protein, ELISA kits. (linscottsdirectory.com)
  • Nevertheless, until the epidemiology and pathogenesis of a newly emerging respiratory pathogen are defined, the use of masks, gowns, and gloves, combined with assiduous hand hygiene and increased environmental disinfection are warranted. (psychiatryadvisor.com)
  • Contact, as with so many respiratory diseases, is what you need to be worried about. (home-remedies-for-you.com)
  • The coronaviruses (order Nidovirales , family Coronaviridae , genus Coronavirus ) are a diverse group of large, enveloped, positive-stranded RNA viruses that cause respiratory and enteric diseases in humans and other animals. (sciencemag.org)
  • Coronaviruses commonly cause mild to moderate upper-respiratory illness in humans, but can cause respiratory, gastrointestinal, liver, and neurologic diseases in animals. (nyhq.org)
  • SARS can be difficult to recognize because it mimics other respiratory diseases, such as influenza. (nyhq.org)
  • Coronaviruses (order Nidovirales , family Coronaviridae , subfamily Coronavirinae ) infect a wide range of vertebrates and cause respiratory, enteric, or less frequently, neurological diseases ( 1 , 2 ). (asm.org)
  • This report published in Communicable Diseases Intelligence, Volume 28, Number 2 describes the epidemiological features of severe acute respiratory syndrome cases reported by Australian states and territories to the Australian Government Department of Health and Ageing between 17 March and 31 July 2003. (cancerscreening.gov.au)
  • In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. (pnas.org)
  • SOURCE: https://bit.ly/3bdCatp American Journal of Respiratory and Critical Care Medicine, online April 29, 2020. (medscape.com)
  • Understand that SARS, which first hit around the year 2002, is Severe acute respiratory syndrome, which is the result of a kind of coronavirus. (home-remedies-for-you.com)
  • Severe acute respiratory syndrome (SARS) is a respiratory illness that first infected people in parts of Asia, North America, and Europe in late 2002 and early 2003. (cigna.com)
  • It was discovered in Chinese patients who had fever and severe breathing problems. (annals.org)
  • SARS is a highly contagious, infectious process that can advance to significant hypoxemic respiratory failure requiring ICU monitoring and support. (sccm.org)
  • WHO coordinated virtual conference (http://www.who.int/csr/sars/cliniciansconference/en/) On 26 March 80 clinicians from 13 countries participated in an electronic "grand rounds" on clinical features and treatment for patients with Severe Acute Respiratory Syndrome (SARS) (1). (eurosurveillance.org)
  • This review compares the clinical features, laboratory aspects and treatment options of severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). (nih.gov)
  • Although there are some similarities in the clinical features, MERS progresses to respiratory failure much more rapidly than SARS. (nih.gov)
  • The summary below is from the full report titled "A Clinical Prediction Rule for Diagnosing Severe Acute Respiratory Syndrome in the Emergency Department. (annals.org)
  • Diagnosis of Reiter's syndrome or Reactive arthritis is very important for treating Reiter's syndrom. (home-remedies-for-you.com)
  • The aim of this study was to investigate pulmonary function and exercise capacity in a group of survivors of the severe acute respiratory syndrome (SARS). (ersjournals.com)
  • In conclusion, pulmonary function defects were detected in half of the recovered severe acute respiratory syndrome patients 3 months after hospital discharge, but the impairment was mild in almost all cases. (ersjournals.com)
  • A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). (pnas.org)
  • The pandemics of severe acute respiratory syndrome (SARS) and influenza H1N1 are recent memories that have heightened the sense of concerns by health care epidemiologists for rapid responses to new and emerging pathogens. (psychiatryadvisor.com)
  • Severe acute respiratory syndrome (SARS) is an infectious condition that can cause serious respiratory illness or death. (lung.org)
  • SARS is a serious respiratory illness that frequently runs a rapidly progressive downhill course. (bmj.com)
  • The 2003 severe acute respiratory syndrome (SARS) epidemic and recent emergence of Middle East respiratory syndrome highlight the potential lethality of zoonotic coronavirus infections in humans. (pnas.org)
  • Dr. Alladina and colleagues describe the respiratory pathophysiology of 66 patients with COVID-19 who were intubated and admitted to the ICU. (medscape.com)
  • A little sensitivity when coming into contact with SARS patients is important since one won't get the respiratory illness with simple casual and short exposure. (home-remedies-for-you.com)
  • Objectives To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). (bmj.com)
  • Serologic test results of convalescent samples were positive in 50 (96.2%) of 52 patients for whom paired serum samples were collected during the acute and convalescent phases of the illness. (cmaj.ca)
  • In patients with SARS, specimens taken from the lower respiratory tract and stool samples test positive by means of RT-PCR more often than do samples taken from other areas. (cmaj.ca)
  • Patients with impending or established respiratory failure should be admitted to ICU or an intermediate care unit. (bmj.com)
  • A cluster of patients with severe acute respiratory syndrome in a chest ward in southern Taiwan. (bmj.com)
  • Critically ill patients with severe acute respiratory syndrome. (bmj.com)
  • Some recent studies would suggest protecting the eyes and mucous membranes when taking care of patients with a novel respiratory pathogen and double gloving instead of wearing a set of single gloves. (psychiatryadvisor.com)
  • In addition, half of the patients with preexisting pain conditions experienced a persistent exacerbation of their previous syndromes. (aau.dk)
  • Coronaviruses are a large family of viruses that cause illness in humans, ranging from the common cold to severe respiratory illness. (virginia.gov)
  • Coronaviruses most often cause mild to moderate upper-respiratory illness. (ahealthyme.com)
  • Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, and severe acute respiratory syndrome coronaviruses (SARS-CoVs). (asm.org)
  • Interest in coronaviruses was largely focused on their impact on domestic porcine and avian husbandry and their utility in animal models of virus-induced demyelination ( 5 ) until the emergence of severe acute respiratory syndrome (SARS) in 2003 ( 6 ). (asm.org)
  • A newly identified acute respiratory syndrome caused by a new virus, the SARS coronavirus, which is believed to recently have crossed the species barrier from animals to humans. (greenfacts.org)
  • Spontaneous pneumomediastinum (SP) unrelated to assisted ventilation is a newly recognised complication of severe acute respiratory syndrome (SARS). (ersjournals.com)
  • In the face of a newly emerging respiratory pathogen, there are theoretical arguments for the use of N-95 masks over the standard surgical masks. (psychiatryadvisor.com)
  • New estimates of the transmissibility of the Middle East respiratory syndrome coronavirus in humans suggest that it does not yet have pandemic potential, according to research published in The Lancet. (medicalxpress.com)
  • A MEDLINE search was performed using the following terms: severe acute respiratory syndrome and SARS virus. (sccm.org)
  • Severe acute respiratory syndrome coronavirus (SCoV) 7a protein is one of the viral accessory proteins. (asm.org)
  • SARS is caused by a type of coronavirus, which can cause mild to moderate upper respiratory illness, such as the common cold. (cigna.com)
  • It can cause mild illness, severe illness, or death. (ahealthyme.com)
  • More severe cases (i.e., those presenting with or developing acute respiratory failure) should be admitted to the ICU or an intermediate care unit under airborne transmission precautions. (bmj.com)
  • Survey of sedation practices during noninvasive positive-pressure ventilation to treat acute respiratory failure. (umassmed.edu)
  • On April 22, 2003, the Taiwan Department of Health (DOH) was notified of seven cases of severe acute respiratory syndrome (SARS) among health-care workers (HCWs) at a large municipal hospital in Taipei (hospital A). Subsequent cases at eight hospitals have been associated with exposures at hospital A. Previously, all reported cases had been associated with persons recently returning to Taiwan from SARS-affected regions. (cdc.gov)
  • Severe acute respiratory syndrome (SARS) is a serious, sometimes fatal, illness caused by a virus called a coronavirus. (annals.org)
  • World Health Organization, Cumulative number of reported probable cases of severe acute respiration syndrome. (ajtmh.org)
  • In March 2003, the World Health Organization (WHO) issued a global alert recommending active worldwide surveillance for severe acute respiratory syndrome (SARS). (cancerscreening.gov.au)
  • SARS is a rapidly progressive respiratory illness that is spread from person to person. (lung.org)
  • Severe cases often evolve rapidly to respiratory distress and require intensive care. (who.int)