Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.
The five-carbon building blocks of TERPENES that derive from MEVALONIC ACID or deoxyxylulose phosphate.
SESQUITERPENES cyclized to one 10-carbon ring.
A plant genus of the family SANTALACEAE which is the source of sandalwood oil.
A plant genus of the family RANUNCULACEAE. Members contain ACONITINE and other diterpenoid alkaloids.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A plant genus of the family ASTERACEAE. Members contain germacrane and sesquiterpene LACTONES.
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
A hemoflagellate subspecies of parasitic protozoa that causes Gambian or West African sleeping sickness in humans. The vector host is usually the tsetse fly (Glossina).
A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
An ancient country in western Asia, by the twentieth century divided among the former USSR, Turkey, and Iran. It was attacked at various times from before the 7th century B.C. to 69 B.C. by Assyrians, Medes, Persians, the Greeks under Alexander, and the Romans. It changed hands frequently in wars between Neo-Persian and Roman Empires from the 3d to 7th centuries and later under Arabs, Seljuks, Byzantines, and Mongols. In the 19th century Armenian nationalism arose but suffered during Russo-Turkish hostilities. It became part of the Soviet Republic in 1921, with part remaining under Turkey. (Webster's New Geographical Dictionary, 1988)
The species Panthera tigris, a large feline inhabiting Asia. Several subspecies exist including the Siberian tiger and Sumatran tiger.
Any of the various plants of the genus Lactuca, especially L. sativa, cultivated for its edible leaves. (From American Heritage Dictionary, 2d ed)
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
A plant genus in the LAURACEAE family. Lindera benzoin is a source of a balsamic resin called benzoin which is up to 1/3 BENZOIC ACID. This should not be confused with the chemical BENZOIN or the plant STYRAX BENZOIDES.
Societies whose membership is limited to physicians.
Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
Enzymes that catalyze the cleavage of a carbon-carbon bond by means other than hydrolysis or oxidation. This subclass contains the DECARBOXYLASES, the ALDEHYDE-LYASES, and the OXO-ACID-LYASES. EC 4.1.
The process of embryo initiation in culture from vegetative, non-gametic, sporophytic, or somatic plant cells.
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.
A plant genus of the family MORACEAE. It is the source of the familiar fig fruit and the latex from this tree contains FICAIN.
The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.
A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.
Heterodimers of FLAVONOIDS bound to LIGNANS.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
A cell line derived from cultured tumor cells.

Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes. (1/2267)

Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.  (+info)

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (2/2267)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria. (3/2267)

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.  (+info)

Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. (4/2267)

6-Hydroxymethylacylfulvene (MGI-114) is a semisynthetic analogue of the toxin illudin S, a product of the Omphalotus mushroom. MGI-114 induces cytotoxicity in a variety of solid tumors in vivo, including the refractory HT29 human colon cancer xenograft. In this study, the potential application of MGI-114 in the treatment of colon cancer was further explored by evaluating the activity of MGI-114 in combination with irinotecan (CPT-11) and 5-fluorouracil (5FU). Groups of 9 nude mice bearing HT29 xenografts were treated with either single agent MGI-114, CPT-11, or 5FU, or MGI-114 in combination with CPT-11 or 5FU. MGI-114 was administered at doses of 3.5 and 7 mg/kg i.p. daily on days 1 through 5, and CPT-11 and 5FU were administered at doses of 50 and 100 mg/kg i.p. on days 1, 12, and 19. In the single agent studies, MGI-114, CPT-11, and 5FU all resulted in decreased final tumor weights compared with vehicle-treated controls (P<0.05), but only MGI-114 at 7 mg/kg produced partial responses. When MGI-114 at 3.5 mg/kg was combined with CPT-11, significant decrements in final tumor weights occurred compared with monotherapy with the same doses of MGI-114 and CPT-11 (P< or =0.001). Also, administration of the low-dose combination (MGI-114 at 35 mg/kg and CPT-11 at 50 mg/kg) resulted in final tumor weights similar to those achieved after administration of high-dose MGI-114 as a single agent. Moreover, the combination of MGI-114 and CPT-11 produced partial responses in nearly all of the animals, with some animals achieving complete responses. The outcome with the combination of MGI-114 and 5FU was less striking, with fewer partial responses and no complete responses. These results suggest enhanced activity when MGI-114 is combined with CPT-11, and clinical trials to further evaluate this combination regimen are planned.  (+info)

A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. (5/2267)

CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002). However, CGP 56697 was more effective than mefloquine in parasite clearance time (43 hr versus 66 hr; P < 0.001) fever clearance time (32 hr versus 54 hr; P < 0.005), and gametocyte clearance time (152 hr versus 331 hr; P < 0.001). This study revealed that CGP 56697 is effective against multidrug-resistant Plasmodium falciparum malaria in Thailand, but higher doses will probably be needed to improve the cure rate.  (+info)

The pharmacokinetics of artemisinin after administration of two different suppositories to healthy Vietnamese subjects. (6/2267)

Eight healthy Vietnamese male subjects received 400 mg artemisinin formulated into fatty suppositories (FS), and six different subjects received 500 mg of artemisinin formulated in polyethylene glycol suppositories (PEGS). Plasma concentrations were measured by high-performance liquid chromatography with electrochemical detection; concentration versus time curves were analyzed with nonparametric methods. No statistically significant differences were found between the two formulations. The maximum concentration (Cmax) was 100 +/- 102 microg/L (mean +/- SD, range = 24-330) microg/L (FS), the pharmacokinetic lag time (Tlag) was 1.3 +/- 1.0 hr (range = 0-3) (FS), and the time of the maximum concentration (Tmax) was 7.1 +/- 2.1 hr (range = 3-10) hr (FS). Because artemisinin is not available for intravenous dosage, absolute bioavailability cannot be assessed. However, compared with a previous study on oral artemisinin in healthy Vietnamese subjects, bioavailability relative to oral administration was estimated to be approximately 30%. We conclude that therapeutic blood concentrations of artemisinin can be reached after rectal dosage. The dose after rectal administration should probably be higher than after oral administration; doubling or tripling the oral dose might be necessary, which would imply a rectal dose of at least 20 mg/kg of body weight given twice a day.  (+info)

Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. (7/2267)

AIM: To compare the effects of huperzine A (Hup A), tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The miniature end-plate potentials (MEPP), the mean quantal content of end-plate potentials (EPP), and the resting membrane potentials of muscle fiber were recorded. RESULTS: Hup A, tacrine, and E2020 at the concentration of 1.0 mumol.L-1 increased the amplitude, time-to-peak, and half-decay time of MEPP in the potencies of E2020 > Hup A > tacrine. Hup A did not significantly change the frequency of MEPP, the appearance of giant MEPP or slow MEPP, the resting membrane potentials, and the mean quantal content of EPP. CONCLUSION: Hup A is a selective and potent cholinesterase inhibitor, by which activity it facilitates the cholinergic transmission at mouse neuromuscular junction, and devoid of pre- and post-synaptic actions.  (+info)

Effect of artemether on glucose uptake and glycogen content in Schistosoma japonicum. (8/2267)

AIM: To study the effect of artemether (Art) on glucose uptake and glycogen content in schistosomes. METHODS: Schistosomes recovered from mice treated intragastrically with Art 300 mg.kg-1 for 24-48 h, were incubated in the drug-free medium containing [U-14C]glucose 11.1 MBq.L-1. The glycogen content, [U-14C]glucose uptake, and incorporation of [U-14C]glucose into worm glycogen in both male and female worms were determined. RESULTS: When above-mentioned schistosomes were exposed to drug-free medium containing [U-14C]glucose for 1-24 h, the glycogen contents of male and female worms decreased 27%-61% and 39%-78%, respectively. Only 3 out of 6 male worm groups showed 23%-35% decrease in glucose uptake, while much less glucose uptake was found in female worms in all groups with reduction rates of 18%-38%. Apart from 2 male groups no apparent change in the incorporation of [U-14C]glucose into the worm glycogen was seen. CONCLUSIONS: Art-induced glycogen reduction in schistosomes was related to an inhibition of glycolysis rather than an interference with glucose uptake.  (+info)

TY - JOUR. T1 - Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.. AU - Emanuele, Sonia. AU - Lauricella, Marianna. AU - Di Fiore, Riccardo. AU - DAnneo, Antonella. AU - Vento, Renza. AU - Carlisi, Daniela. AU - Buttitta, Giuseppina. AU - Vento, Renza. AU - Tesoriere, null. AU - Tesoriere, Giovanni. PY - 2013. Y1 - 2013. N2 - The sesquiterpene lactone parthenolide (PN) has recently attracted considerable attention because of its anti-microbial, anti-inflammatory and anticancer effects. However, the mechanism of its cytotoxic action on tumor cells remains scarcely defined. We recently provided evidence that the effect exerted by PN in MDA-MB-231 breast cancer cells was mediated by the production of reactive oxygen species (ROS). The present study shows that PN promoted the phosphorylation of EGF receptor (phospho-EGFR) at Tyr1173, an event which was observed already at 1 h of incubation with 25 µM PN and reached a peak at 8-16 h. ...
TY - THES. T1 - Total synthesis of cis-Hydroazulene sesquiterpenes : base-induced and -directed elimination and rearrangement reactions of perhydronaphthalene-1,4-diol monosulfonate esters. AU - Jenniskens, L.H.D.. N1 - WU thesis 1539 Proefschrift Wageningen. PY - 1992. Y1 - 1992. N2 - The total synthesis of a number of cis-fused hydroazulene sesquiterpenes is described in this thesis. In this synthetic study, ample attention is paid to the mechanistic aspects of the base- induced and -directed rearrangement and elimination reactions of perhydronaphthalene-1,4-diol monosulfonate esters. These reactions form the key steps in the synthetic routes that were followed.A general introduction into the chemistry of terpenes, with emphasis laid on the sesquiterpenes with a hydroazulene skeleton, is given in Chapter 1.In Chapter 2, an overview of the literature on the synthesis of these hydroazulene sesquiterpenes is presented. The different synthetic strategies towards the hydroazulene skeleton and their ...
TY - JOUR. T1 - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. AU - Shieh, Ying Hua. AU - Huang, Huei Mei. AU - Wang, Ching Chiung. AU - Lee, Chen Chen. AU - Fan, Chia Kwung. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the antiallergic activity and the underlying mechanism of zerumbone have not been reported. Herein, we investigated the immunomodulatory effects of zerumbone on antigen-presenting dendritic cells (DCs) in vitro and its potential therapeutic effects against ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T cell proliferation ...
Abstract: Sesquiterpene lactones have long been used in traditional Chinese medicines to treat inflammatory diseases. Recently, sesquiterpene lactone family compounds have been recognized as potential anticancer agents. Thus, it is necessary to explore new sesquiterpene lactones and their antitumor mechanism for cancer treatments. In the present study, we have explored the potential anti-cancer activity of a novel sesquiterpene lactone compound santamarine (STM) in HepG2 cells. It inhibited proliferation and induced apoptosis dose-dependently with IC50 ~ 70 μM. Induction of apoptosis was found to be linked with increased reactive oxygen species (ROS) generation, decreased activity of thioredoxin reductase (TrxR), glutathione (GSH) depletion, mitochondrial membrane potential (ΔΨm) dissipation, Bcl-2 family proteins modulation, cytochrome c release, caspases-9, -8 and -3 activation and PARP cleavage. Further mechanistic study demonstrated that STM inhibited the constitutive and TNF-α-induced ...
Beta-caryophyllene is an odoriferous bicyclic sesquiterpene found in various herbs and spices. Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). Activation of CB2 will decrease pain, a major signal for inflammatory responses. We hypothesized that beta-caryophyllene can affect wound healing by decreasing inflammation. Here we show that cutaneous wounds of mice treated with beta-caryophyllene had enhanced re-epithelialization. The treated tissue showed increased cell proliferation and cells treated with beta-caryophyllene showed enhanced cell migration, suggesting that the higher re-epithelialization is due to enhanced cell proliferation and cell migration. The treated tissues also had up-regulated gene expression for hair follicle bulge stem cells. Olfactory receptors were not involved in the enhanced wound healing. Transient Receptor Potential channel genes were up-regulated in the injured skin exposed to beta-caryophyllene. Interestingly, there were sex
Contribution to the elucidation of the anti-inflammatory activity of sesquiterpene lactones [Elektronische Ressource] / vorgelegt von Alfonso J. García Piñeres : Contribution to the Elucidation of the Anti-inflammatory Activity of Sesquiterpene Lactones Inaugural-Dissertation zur Erlangung der Doktorwürde der Fakultät für Chemie, Pharmazie und Geowissenschaften der Albert-Ludwigs-Universität Freiburg im Breisgau vorgelegt von Alfonso J. García Piñeres aus San José, Costa Rica April 2003 Gedruckt mit Unterstützung
Sesquiterpenes are a class of terpenes that consist of three isoprene units and have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be acyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Oxidation of farnesene then provides sesquiterpenoids such as farnesol. There are more cyclic sesquiterpenes than cyclic monoterpenes because of the increased chain length and additional double bond. In addition to common six-membered ring systems such as is found in zingiberene (a constituent of the oil from ginger), cyclization of one end of the chain to the other end can ...
Parthenin and parthenolide are natural products that are closely related in structure to artemisinin, which is also a sesquiterpene lactone (SQL) and one of the most important antimalarial drugs available. Parthenin, like artemisinin, has an effect onPlasmodiumblood stage development. We extended the evaluation of parthenin as a potential therapeutic for the transmissible stages ofPlasmodium falciparumas it transitions between human and mosquito, with the aim of gaining potential mechanistic insight into the inhibitory activity of this compound. We posited that if parthenin targets different biological pathways in the parasite, this in turn could pave the way for the development of druggable compounds that could prevent the spread of artemisinin-resistant parasites. We examined parthenins effect on male gamete activation and the ookinete-to-oocyst transition in the mosquito as well as on stage V gametocytes that are present in peripheral blood. Parthenin arrested parasite development for each ...
Five new tremulane-type sesquiterpenes, 11,12-dihydroxy-1-tremulen-5-one (1), 11,12-epoxy-12 beta-hydroxy-1-tremulen-5-one (2), 5 alpha, 12-dihydroxy-1-tremulen-11-yl 2(S)-pyroglutamate (3), 2 alpha, 11-dihydroxy-1(10)-tremulen-5,12-olide (4), and 10 beta,11-dihydroxy-5,6-seco-1,6(13)-tremuladien-5,12-olide (5), as well as three new aliphatic diketones, 2,3-dihydroxydodecane-4,7-dione (9 and 10) and 1-hydroxydecane-2,5-dione (11), together with three known sesquiterpene analogues, tremulenediol A (6), conocenol B (7), and conocenolide A (8), were isolated from cultures of the basidiomycete Conocybe siliginea ...
TY - JOUR. T1 - Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities. AU - Robles, Andrew J.. AU - Peng, Jiangnan. AU - Hartley, Rachel M.. AU - Lee, Brigette. AU - Mooberry, Susan L.. PY - 2015/3/27. Y1 - 2015/3/27. N2 - A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known germacranolide sesquiterpene lactones, leucanthin-A (2), leucanthin-B (3), melampodin-A acetate (4), and 3α-hydroxyenhydrin (5). The chemical structure of 1 was elucidated by analysis of 1D and 2D NMR and mass spectrometric data. All compounds exhibited antiproliferative and cytotoxic efficacy against PC-3 and DU 145 prostate cancer cells, as well as HeLa cervical cancer cells, with IC50 values ranging from 0.18 to 9 μM. These compounds were effective in clonogenic assays and displayed high cellular persistence. They were also found to be capable of circumventing ...
Phytoalexins are low molecular weight antimicrobial compounds that are produced by plants as a response to biotic and abiotic stresses. The rapidity and extent of their accumulation is determined by their release of immediate precursors from conjugates or de novo synthesis, as well as detoxification as a result of plant or microbial enzymes. The rapidity of phytoalexin accumulation is associated with resistance in plants to diseases caused by fungi and bacteria, although the genetic information for phytoalexin synthesis is found in susceptible and resistant plants. Phytoalexins are only one component of the complex mechanisms for disease resistance in plants.
Five new triquinane-type sesquiterpenes, antrodins A-E (1-5) and a new gymnomitrane sesquiterpene, antrodin F (6), together with three known compounds 7-9 were isolated from fermentation of Antrodiella albocinnamomea. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 and 6 were determined using single-crystal X-ray diffraction analyses. The isolated compounds were investigated for their cytotoxicities against five human cancer cell lines. (C) 2015 Elsevier B.V. All rights reserved ...
Jekk inti qed jippjanaw li terpenoids bl-ingrossa, glycosides, sesquiterpenes, estratt tal-pjanti minn wieħed mill-fabbrikanti ta l-psoralen Ċina professjonali u fornituri, Nitolbok li tħossok liberu li tikkuntattja Baoji Herbest Bio bpotenzal Co., Ltd.
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids ...
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids ...
Definition of parthenolide in US English - A sesquiterpene lactone, C₁₅H₂₀O₃, with antibacterial and cytotoxic properties which is the active ingredient in prepara
A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which… Expand ...
Other names: 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, [S-(Z)]-; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (Z)-(S)-(+)-; (+)-Nerolidol; D-Nerolidol; Nerolidol, cis-(+)-; Peruviol; 3,7,11-Trimethyl-1,6,10-dodecatriene-3-ol, (Z)-(S)-(+)-; (6Z)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (3S,6Z)-; NSC 60598; (Z)-Nerolidol; cis-Nerolidol; Nerolidol (Z); (Z)-«beta»-Nerolidol; cis-Nerolidol A ...
Other names: 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, [S-(Z)]-; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (Z)-(S)-(+)-; (+)-Nerolidol; D-Nerolidol; Nerolidol, cis-(+)-; Peruviol; 3,7,11-Trimethyl-1,6,10-dodecatriene-3-ol, (Z)-(S)-(+)-; (6Z)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (3S,6Z)-; NSC 60598; (Z)-Nerolidol; cis-Nerolidol; Nerolidol (Z); (Z)-«beta»-Nerolidol; cis-Nerolidol A ...
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5185 The potent induction of apoptosis in various types of tumor cells, contrasted to largely reversible non-apoptotic effects in normal cells is one of the hallmarks of a novel dual-action DNA- and protein-alkylating drug, irofulven (hydroxymethylacylfulvene). Previous studies suggested the contribution of both nuclear and cytoplasmic signaling to apoptosis by irofulven. To better understand the nature of the differential responses of tumor and normal cells, we used a cell-free apoptosis mimicking system consisting of isolated nuclei and cytosolic extracts. We examined homologous and heterologous mixes of nuclei and cytosols from cancer cells (CEM and LNCaP-Pro5), which initiate apoptosis in response to irofulven, and from normal cells (NCM 460), which display a non-apoptotic cytostatic response. Cytosols were obtained either from untreated or drug-treated cells. In the latter case, irofulven concentrations were adjusted to provide equal levels of intracellular drug-macromolecule adducts in ...
Beta-caryophyllene, a common cannabis terpene, can help you manage pain. Learn more about these high-caryophyllene strains & where you can find them.
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Welcome to 4hbtalk.com - The largest 4 Hour Body forum. This forum is a place where you can ask questions about exercises, the slow carb diet, the PAGG stack or anything related to creating your four hour body. The forum was built around The 4-Hour body book by Tim Ferris. This community is in no way affiliated with the 4 Hour Body or Tim Ferris.
Welcome to 4hbtalk.com - The largest 4 Hour Body forum. This forum is a place where you can ask questions about exercises, the slow carb diet, the PAGG stack or anything related to creating your four hour body. The forum was built around The 4-Hour body book by Tim Ferris. This community is in no way affiliated with the 4 Hour Body or Tim Ferris.
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Display omitted] New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as ...
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
Cancers energy source can be thwarted by a naturally-occurring molecule which stops affected cells from consuming sugar, according to a new study. Koningic acid (KA) was found to disrupt the metabolism of cancerous cells. Published in Cell...
article{76337ac6-36e6-4fff-b6e8-dfb8093c0fd5, abstract = {A clone encoding farnesyl diphosphate synthase (FPPS) was obtained by PCR from a cDNA library made from young leaves of Artemisia annua. A cDNA clone encoding the tobacco epi-aristolochene synthase (eAS) was kindly supplied by J. Chappell (University of Kentucky, Lexington, KY, USA). Two fusions were constructed, i.e. FPPS/eAS and eAS/FPPS. The stop codon of the N-terminal enzyme was removed and replaced by a short peptide (Gly-Ser-Gly) to introduce a linker between the two ORFs. These two fusions and the two single cDNA clones were separately introduced into a bacterial expression vector (pET32). Escherichia coli was transformed with the expression vectors and enzymatically active soluble proteins were obtained after induction with isopropyl thio-beta-d-thiogalactoside. The recombinant enzymes were purified using immobilized metal affinity chromatography on Co2+ columns. The fusion enzymes produced epi-aristolochene from isopentenyl ...
Sesquiterpene cyclase, a branch point enzyme in the general isoprenoid pathway for the synthesis of phytoalexin capsidiol, was induced in detached leaves of Capsicum annuum (pepper) by UV treatment. The inducibility of cyclase enzyme activities paralleled the absolute amount of cyclase protein(s) of pepper immunodetected by monoclonal antibodies raised against tobacco sesquiterpene cyclase. A cDNA library was constructed with poly(A)+ RNA isolated from 24 h UV-challenged leaves of pepper. A cDNA clone for sesquiterpene cyclase in pepper was isolated by using a tobacco 5-epi aristolochene synthase gene as a hetero-logous probe. The predicted protein encoded by this cDNA was comprised of 559 amino acids and had a relative molecular mass of 65,095. The primary structural information from the cDNA clone revealed that it shared 77%, 72% and 49% identity with 5-epi aristolochene, vetispiradiene, and cadinene synthase, respectively. The enzymatic product catalyzed by the cDNA clone in bacteria was ...
It has been suggested that jasmonic acid (JA) could be an integral part of a general signal transduction system regulating inducible defense genes in plants. It was reported that treatment with an elicitor (N-acetylchitoheptaose) induced production of phytoalexin in suspension-cultured rice (Oryza sativa L.) cells. In this study, the role of JA in the induction of phytoalexin production by N-acetylchitoheptaose was investigated. Exogenously applied ([plus or minus])-JA (10-4 M) clearly induced the production of momilactone A, a major phytoalexin, in suspension-cultured rice cells. On the other hand, in rice cells treated with N-acetylchitoheptaose, endogenous JA was rapidly and transiently accumulated prior to accumulation of momilactone A. Treatment with ibuprofen, an inhibitor of JA biosynthesis, reduced production of momilactone A in the cells treated with N-acetylchitoheptaose, but the addition of ([plus or minus])-JA increased production of momilactone A to levels higher than those in the ...
Read WRKY45-dependent priming of diterpenoid phytoalexin biosynthesis in rice and the role of cytokinin in triggering the reaction, Plant Molecular Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Principal Investigator:KODAMA Shoji, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Obstetrics and gynecology
The diseased wood, agarwood, from the tropical tree taxa Aquilaria, is famed for its unique fragrance and medicinal values, mainly due to its richness in secondary metabolites such as the sesquiterpenes. The presence of sesquiterpenes in high numbers and amounts correlates with agarwood of high quality. To understand the synthesis of this important compound, we cloned two candidate genes in the terpenoid synthesis pathway from Aquilaria malaccensis Lam., a major agarwood tree species. The genes encoding sesquiterpene synthase (AmSesTPS1) and δ-guaiene synthase (AmGuaiS1) were successfully cloned from callus RNA, using specific primers derived from transcriptomic data, in a reverse transcription PCR reaction. The full-length complementary DNA (cDNA) sequence of AmSesTPS1 was 1632 bp encoding for 544 amino acids, and AmGuaiS1 was 1644 bp encoding for 547 amino acids. Sequence alignment analysis showed that AmSesTPS1 shared between 99 to 100 % identity with sesquiterpene synthase from Aquilaria sinensis
The current evolutionary hypothesis and the previous phylogenetic tree (Bohlmannet al. 1998b) both affirm that plant terpene synthases involved in secondary metabolism have a common ancestral origin from a terpene synthase involved in primary metabolism. However, these models differ in the placement of the class III terpene synthases (Figures 6, A and B, and 7). The inferred phylogenetic tree in Figure 6A suggests that the class III types (angiosperm terpene synthases) involved in secondary metabolism are descendants (evolving by divergent evolution) of the class II types (gymnosperm monoterpene and/or sesquiterpene synthases) involved in secondary metabolism, whereas Figure 6B indicates that class III types are not direct descendants of class II types, yet share a common ancestor. The latter (including the gene architecture information as valid) infers that gymnosperm and angiosperm terpene synthases involved in secondary metabolism diverged prior to the three loss events illustrated in Figure ...
Huperzine-A Review Introduction Huperzine-A is a unique chemical purified from the Chinese plant Huperzia Serrata or chinese moss. Its main functionality is as
TY - JOUR. T1 - A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis. AU - Kim, Youn C.. AU - Bolzani, Vanderlan Da S.. AU - Baj, Nina. AU - Gunatilaka, A. A.Leslie. AU - Kingston, David G.I.. PY - 1996/2/15. Y1 - 1996/2/15. N2 - Bioassay-guided fractionation of an MeCOEt extract of Frullania nisquallensis Sull. has furnished a DNA-damaging sesquiterpene, costunolide (1), and two inactive compounds, a sesquiterpene (-)-frullanolide (2) and a tridepside tenuiorin (3). 13C-NMR data of 3 are reported.. AB - Bioassay-guided fractionation of an MeCOEt extract of Frullania nisquallensis Sull. has furnished a DNA-damaging sesquiterpene, costunolide (1), and two inactive compounds, a sesquiterpene (-)-frullanolide (2) and a tridepside tenuiorin (3). 13C-NMR data of 3 are reported.. UR - http://www.scopus.com/inward/record.url?scp=0030065818&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030065818&partnerID=8YFLogxK. U2 - 10.1055/s-2006-957800. DO - ...
The Asteraceae, one of the largest families among angiosperms, is chemically characterised by the production of sesquiterpene lactones (SLs). A total of 1,111 SLs, which were extracted from 658 species, 161 genera, 63 subtribes and 15 tribes of Asteraceae, were represented and registered in two dimensions in the SISTEMATX, an in-house software system, and were associated with their botanical sources. The respective 11 block of descriptors: Constitutional, Functional groups, BCUT, Atom-centred, 2D autocorrelations, Topological, Geometrical, RDF, 3D-MoRSE, GETAWAY and WHIM were used as input data to separate the botanical occurrences through self-organising maps. Maps that were generated with each descriptor divided the Asteraceae tribes, with total index values between 66.7% and 83.6%. The analysis of the results shows evident similarities among the Heliantheae, Helenieae and Eupatorieae tribes as well as between the Anthemideae and Inuleae tribes. Those observations are in agreement with systematic
Evaluation of herbicide potential of sesquiterpene lactone and flavonoid: impact on germination, seedling growth indices and root length in arabidopsis ...
Compound potency: IC50 and MLC determination.Cell viability assays are affected not just by the kinetics of the targeted protein (most likely MetAP2 in this case) but also by additional factors, such as compound permeation across the trophozoite membrane and the susceptibility of the compound to degrading cellular enzymes. These factors also affect compound efficacy in vivo. Additionally, both in vitro and in vivo cell viability may be affected by unknown off-target inhibition. Although the only validated target of fumagillol derivatives is MetAP2, the MetAP2-independent effects of fumagillin on angiogenesis are known (34, 35). As angiogenesis does not exist in G. lamblia, currently, there is no alternative MapAP2-independent activity of fumagillin that could be tested. Nevertheless, the possibility of a contribution of off-target inhibition to the lethal effects of drug candidates cannot be excluded.. Antigiardia assays followed by enzyme inhibition determination facilitated the selection of ...
Preparations of lung homogenates. Animals were sacrificed by an overdose of ketamin 24h after the last drug administration. Lungs were removed and washed with cold PBS three times in order to remove blood. Lung tissues were taken into 2ml microcentrifuge tubes and stored at −80°C until analysis. On the study day, frozen lungs were thawed, weighed (60-80mg), transferred into different tubes on ice containing 5ml of stainless beads, 0.1% SDS, protease inhibitor cocktail (Sigma-Aldrich, St. Louis, MO, USA) and 0.1mg/ml phenylmethanesulfonyl fluoride (PMSF) in PBS. Microcentrifuge tubes were transferred to precooled Tissuelyser LT racks and placed into TissueLyser (Qiagen, Germany) homogenisator. Frequency and time were set to 50 and 5min, respectively. The homogenates were then centrifugated at 15,000×g for 1h at 4°C. The supernatants were stored at −80°C.. Measurement of cytokines. Levels of IL-4 and IL-5 were quantified in the supernatants of the lung tissue by standard ELISA protocols ...
Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Citation: N/A Interpretive Summary: Technical Abstract: Phytoalexins are inducible biochemicals that locally protect plant tissues against biotic attack. Due to their agronomic significance, maize and rice have been extensively investigated for their terpenoid-based defenses which include insect-inducible monoterpene and sesquiterpene volatiles. Rice also produces a complex array of non-volatile pathogen-inducible terpenoid phytoalexins; however, until recently analogous pathways in maize were unknown. We recently discovered the existence of a complex series of sesquiterpene and diterpene phytoalexins in maize stalks following attack by the European corn borer (Ostrinia nubilalis) and pathogenic fungi. The predominant acidic sesquiterpene and diterpene phytoalexins, termed zealexins and kauralexins, are likely derived from ß-macrocarpene and ent-kaur-15-ene, respectively. Following induction, the predicted volatile terpenoid precursors exist at relatively low levels compared to the oxygenated ...
The liver is the only organ that can be continually regenerated and that is because humans have evolved to eat plants, and phytoalexins take their toll on the liver. As plants are digested and absorbed in the small intestines and transported to the liver, phytoalexins accompany the nutrients. Most of the phytochemicals are chemically detoxified by liver enzymes, but the phytoalexins kill some liver cells with each meal and some of the phytoalexins circulate in the blood and reach other tissues. The phytoalexins are evolutionarily adapted to bind to proteins to disrupt essential enzymes of microorganisms and herbivores, and like pharmaceuticals to which they are chemically and functionally related, they have numerous side effects. The chemical reactivity is what is detected as the antioxidant property of phytoalexins. Antioxidant is nutritionally meaningless and basically reflects the chemical toxicity of phytochemicals. After all, you cant easily sell chemicals that are inherently toxic. Meat ...
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Huperzine A is an Acetylcholinesterase Inhibitor that boosts Memory & treats Alzheimers. Read reviews on dosages, benefits and effects of Huperzine A.
delta-selinene synthase: a sesquiterpene synthase from Grand fir, Abies grandis; forms a total of 34 different sesquiterpenes, chiefly delta-selinene; MW 68 kDa; amino acid sequence in first source; GenBank U92267
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the trivial name for any of four possible stereoisomers of 3,7,11‐trimethyl‐2,6,10‐dodecatrien‐1‐ol; a sesquiterpene alcohol. The 2E,6E‐isomer is found in many essential oils. The 2Z,6E‐isomer is a minor constituent of some essential oils.. [...] ...
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Last week, Lab Land noticed similarities between two independent lines of research from the Escayg and Traynelis/Yuan labs at Emory. Both were published recently and deal with rare forms of genetic epilepsy, in which molecular understanding of the cause leads to individualized treatment, albeit with limited benefit.. Both conditions are linked to an excess of neuronal excitation, and both can be addressed using medications that have also been tested for Alzheimers. A critical difference is that memantine is FDA-approved for Alzheimers, but huperzine A is not.. ...
Brain Protex w/Huperzine A supports the overall health of the brain. It facilitates circulation to and within the brain, which may offer subsequent benefits. It may also help slow the breakdown of the important neurotransmitter acetylcholine.
Many people would like to know about what Huperzine A science there is to back up the many claims. In this article, we explore research into this Nootropic.
In the world of cannabis science, few things are more exciting than our developing knowledge of the world of terpenes.. Terpenes can be found in the essential oils of all plants. In cannabis, they play a major role in how our bodies interact with particular strains. Terpenes give us a better understanding of how strains may interact with us individually and can allow us to better curate the experience were looking for. Most famously, terpenes are responsible for the way cannabis hits your nose. Those lemon, grape and fuel smells that denote world-class cannabis for many connoisseurs are actually variations in the concentration of particular terpenes from strain to strain!. Researchers have identified more than 140 terpenoids in cannabis that include terpenes and their variations, called diterpenes and sesquiterpenes. Of those 140 terpenoids, 17 have been found to be the most common in most cannabis strains.. Currently, were expanding our knowledge around the synergistic effects of cannabinoids ...
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Ive been growing something called Italian dandelion for some time. Actually, since it seems to be perennial, and has really deep roots, I cant actually dig it all out. Its quite attractive and tasty, if prepared by leaching out most of the bitter sesquiterpene lactones first! It does appear to be a selection of common dandelion, Taraxacum officinale; my plants came from seed ordered from The Cooks Garden. ...
Data for artesunate, used for the treatment of malaria, indicates IVC in conjunction with IV Artesunate makes a substantial difference in advanced cancers.
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C. Blöch (WU) project "Phylogeny of the genus Leontopodium" S. Safer: Blattmaterial entnommen für Projekt Leontopodium,
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... and sesquiterpenes. Herout, Vlastimil; Benesova, Vera; Pliva, Josef (1953). "Terpenes. XLI. Sesquiterpenes of ginger oil". ... Zingiberene is a monocyclic sesquiterpene that is the predominant constituent of the oil of ginger (Zingiber officinale), from ...
Garcez, W. S.; Garcez, F. R.; Ramos, L.; Camargo, M. J.; Damasceno Jr., G. A. (1997). "Sesquiterpenes from Trichilia catigua". ...
Laurence G. Cool (2005). "Sesquiterpenes from Cupressus macrocarpa foliage". Phytochemistry. 66 (2): 249-260. doi:10.1016/j. ... Unusual sesquiterpenes can be found in the foliage. Longiborneol (also known as juniperol or macrocarpol) can also be isolated ...
The active agent has not been identified but thought to be sesquiterpenes, which have been isolated from this species and the ... 1980). Sesquiterpenes from Russula sardonia. Phytochemistry 19: 93-97 Benjamin, Denis R. (1995). Mushrooms: poisons and ...
"Sesquiterpenes from the Formosan StoloniferTubiporamusica". Journal of Natural Products. 64 (11): 1430-1433. doi:10.1021/ ...
The latex contains sesquiterpene pigments with guaiane skeletons; these include the compounds given the common names ... 9 (4): 247-8. doi:10.1016/0305-1978(81)90002-8. De Rosa S, De Stefano S (1986). "Guaiane sesquiterpenes from Lactarius ... "The isolation of a guaiane sesquiterpene from fruit bodies of Lactarius sanguifluus". Phytochemistry. 28 (9): 2501-2. doi: ...
additional sesquiterpenes Joseph P. Hou; Youyu Jin (2005-04-25). The healing power of Chinese herbs and medicinal recipes. ... Wang, H. X.; Liu, C. M.; Liu, Q.; Gao, K. (2008). "Three types of sesquiterpenes from rhizomes of Atractylodes lancea". ...
2009). Sesquiterpenes from Curcuma comosa. Journal of Natural Medicines 63 102. Association of the School of Thai Traditional ...
Artemisinin is a sesquiterpene lactone with an endoperoxide bridge and has been produced as an antimalarial drug. The efficacy ... Other phytochemicals include 38 sesquiterpenes. Dihydroartemisinin is the active metabolite of artemisinin, and artesunate is a ...
... is a sesquiterpene and chemical constituent of Nardostachys jatamansi. In in vitro studies, the compound has ... Itokawa H, Masuyama K, Morita H, Takeya K (1993). "Cytotoxic sesquiterpenes from Nardostachys chinensis". Chemical & ...
The active agent has not been identified but is thought to consist of sesquiterpenes, which have been isolated from Russula ... 1980). "Sesquiterpenes from Russula sardonia." Phytochemistry 19: 93-97 Benjamin, Denis R. (1995). Mushrooms: Poisons and ...
This sesquiterpene alcohol is thought to be formed in carrot seeds (Daucus carota L., Umbelliferae) during the vegetation ... Parker, W.; Roberts, J.S. (1967). "Sesquiterpene Biogenesis". Quart. Rev. 21 (3): 331-363. doi:10.1039/qr9672100331.. ... This type of cyclisation is unconventional for the typical chemistry of sesquiterpenes. The only other proposed mechanism ...
Chemically, the copaenes are tricyclic sesquiterpenes. The molecules are chiral, and the α-copaene enantiomer most commonly ... Minor Sesquiterpenes of the Wood of Pinus silvestris L. And of Swedish Sulphate Turpentine". Acta Chemica Scandinavica. 21: 152 ...
Neosporol, Sporol". Part B: Bicyclic and Tricyclic Sesquiterpenes. The Total Synthesis of Natural Products. 11. John Wiley & ...
The term cadinene has sometimes also been used in a broad sense to refer to any sesquiterpene with the so-called cadalane (4- ...
... s are a class of sesquiterpenes. The most important structural features causing the biological activities of ...
Büchi, G.; Hofheinz, W.; Paukstelis, J. V. (November 1969). "Synthesis of (-)-aromadendrene and related sesquiterpenes". ...
New farnesane sesquiterpenes from Lactarius porninsis". Journal of Natural Products. 56 (11): 1948-53. doi:10.1021/np50101a013 ... are rapidly converted to the farnesane-type sesquiterpenes porninsal and porninsol. These chemicals are part of a wound- ...
A sesquiterpene[which?] has been isolated and a synthetic derivative of the ketone form has been commercially produced in Japan ... An example of a sesquiterpene that has been isolated and characterized is oplapanone. "Oplopanax japonicus - (Nakai.)Nakai". ... a new sesquiterpene from oplopanax japonicus (NAKAI) NAKAI". Tetrahedron. 22: 219-225. doi:10.1016/s0040-4020(01)99108-2. Media ...
Sesquiterpenes consist of three isoprene units and have the molecular formula C15H24. Examples of sesquiterpenes and ... Humulene, a sesquiterpene. Taxadiene, a diterpene, precursor to the diterpenoid taxol, an anticancer agent. Squalene, a ... For example, the aroma and flavor of hops comes, in part, from sesquiterpenes (mainly α-humulene and β-caryophyllene), which ... Terpenes are further classified by the number of carbons: monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), etc. A ...
These are mainly volatile terpenes and sesquiterpenes. α-Pinene Myrcene Linalool Limonene Trans-β-ocimene α-Terpinolene Trans- ...
Davis, Edward M.; Croteau, Rodney (2000). "Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and ... Ashour, Mohamed; Wink, Michael; Gershenzon, Jonathan (2010). "Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes and ...
"Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi". Tetrahedron. 68 (39): 8261-8266. doi:10.1016/j.tet. ...
They occur naturally as part of a mixture of sesquiterpenes based upon the bisabolane scaffold. Sesquiterpenes of this family ... The first sesquiterpene to be formed, (E)-α-bisabolene (formed by (E)-α-bisabolene synthase), can be further transformed into ... Sesquiterpenes are a class of terpenoids based upon a 15-carbon unit scaffold synthesized from isoprene units via the ... The transcription of sesquiterpene synthases was shown to begin on the third day following insect attack. Sesquiterpenoid JHAs ...
Chen, K. S.; Hsieh, P. W.; Hwang, T. L.; Chang, F. R.; Wu, Y. C. (2005). "Anti-inflammatory furanogermacrane sesquiterpenes ... The hydrodistillated leaf essential oil of N. parvigemma has antifungal and anti-wood-decay fungal properties Sesquiterpenes ...
Chlorine-Containing Sesquiterpenes of Higher Plants Archived 2011-07-18 at the Wayback Machine Valery M. Dembitsky and Genrich ... The plant contains two cytotoxic indanonic sesquiterpenes. The range within Australia is Central Australia (Northern Territory ...
Eilbert F, Engler-Lohr M, Anke H, Sterner O (September 2000). "Bioactive sesquiterpenes from the basidiomycete Resupinatus ...
The sesquiterpenes ranged from 5.2 to 48.6%. The most abundant monoterpene was β-myrcene, followed by trans-caryophyllene, α- ... Monoterpenes showed a significantly greater loss than sesquiterpenes, but none of the major components completely disappeared ... The 57 identified constituents were 92% monoterpenes, 7% sesquiterpenes, and approx. 1% other compounds (ketones, esters). The ... sesquiterpenes, and other terpenoid compounds. The typical scent of hemp results from about 140 different terpenoids. The ...
ISBN 978-0-7627-3109-1. Zheng Y-B, Lu C-H, Zheng Z-H, Lin X-J, Su W-J, Shen Y-M (2008). "New sesquiterpenes from edible fungus ... The sesquiterpenes compounds pyxidatols A-C, tsuicoline E and omphadiol have been obtained from the liquid culture of this ...
... is a sesquiterpene. It can be extracted from flower of chamomille (Matricaria chamomilla). Matricin is colorless. ...
... which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than ... Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like ... Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. They are found in ... Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. The reaction ...
Sesquiterpene lactones (SLs) are a class of sesquiterpenoids that contain a lactone ring. They are most often found in plants ... Media related to Sesquiterpene lactones at Wikimedia Commons Ghantous, Akram; Gali-Muhtasib, Hala; Vuorela, Heikki; Saliba, ... DallAcqua S, Viola G, Giorgetti M, Loi MC, Innocenti G (August 2006). "Two new sesquiterpene lactones from the leaves of ... Sesquiterpene lactones can be divided into several main classes including germacranolides, heliangolides, guaianolides, ...
Lactone Vanillin Sesquiterpene Lactone Lactone Ring Activity Grade Institute of the Chemistry of Plant Substances, Academy of ...
The role of pyrophosphate (OPP−) in the penultimate deprotonation step leading to olefinic sesquiterpenes is also examined. , ... Santalene and bergamotene are the major olefinic sesquiterpenes responsible for the fragrance of sandalwood oil. Herein we ... is highly valued for its fragrant heartwood oil and is dominated by a blend of sesquiterpenes. Sesquiterpenes are formed ... is highly valued for its fragrant heartwood oil and is dominated by a blend of sesquiterpenes. Sesquiterpenes are formed ...
Look up sesquiterpene in Wiktionary, the free dictionary.. *Sesquiterpenes at the US National Library of Medicine Medical ... Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like ... "Sesquiterpene Lactones and their toxicity to livestock". Cornell CALS. Cornell University. Retrieved December 29, 2018.. ... Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. They are found in ...
The different skeletal types of sesquiterpene lactones (SLs) are classified on the basis of their carbocyclic ring skeleton, in ... The sesquiterpene lactone chemistry of the genus Parthenium. Phytochemistry 10: 1145-1154.CrossRefGoogle Scholar ... Arteannuin-C., a sesquiterpene lactone from Artemisia annua. Phytochemistry 25: 2892-2893.CrossRefGoogle Scholar ... Sesquiterpene lactones-insect feeding deterrents in Vernonia. Biochem. System. Ecol. 2: 25-29.CrossRefGoogle Scholar ...
These in turn are produced by a diverse range of sesquiterpene synthases. A comprehensive analysis of these enzymes in terms of ... An analysis of characterized plant sesquiterpene synthases. Durairaj, Janani; Girolamo, Alice Di; Bouwmeester, Harro J.; Ridder ... Plants exhibit a vast array of sesquiterpenes, C15 hydrocarbons which often function as herbivore-repellents or pollinator- ... To address this, we have gathered 262 plant sesquiterpene synthase sequences with experimentally characterized products. The ...
Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, ... Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific ... Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene ... Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of ,i,Asteraceae,/i, family, with over ...
Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice.. Kim M1, Miyamoto S, Yasui Y, Oyama ...
Total sesquiterpene content was similar across the entire sample collection; however sesquiterpene composition was highly ... sesquiterpene-rich heartwood; however sandalwood fragrance qualities vary substantially, which is of interest to the sandalwood ... and semi-arid southwestern regions of West Australia for patterns in composition and co-occurrence of sesquiterpenes. ... Total sesquiterpene content was similar across the entire sample collection; however sesquiterpene composition was highly ...
vii) Retention time: 12.4 min α-dihydroartemisinin, 12.8 min β-dihydroartemisinin, 15.2 min dihydroartemisinic aldehyde, 15.5 min arteannuin B, 15.7 min dihydroartemisinic acid, 18.8 min dihydroartemisinic alcohol, 36.6 min artemisitene, 37.7 min artemisinin, and 23.7 min artemisinic ...
... a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro. ... Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in ... Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in ...
Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm† Njogu M. Kimani 1. ... All these elemanolide sesquiterpene lactones showed in vitro anti-trypanosomal activity. They were also tested for cytotoxicity ... "Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm." Molecules 22, no. 4: 597. ... Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm. Molecules. 2017; 22(4):597. ...
Antibodies for proteins involved in sesquiterpene biosynthetic process pathways, according to their Panther/Gene Ontology ...
Kamada T, Vairappan CS (2015) New laurene-type sesquiterpene from Bornean Laurencia nangii. Nat Prod Commun 10:843-844PubMed ... New sesquiterpenes from Laurencia majuscula (Rhodophyta, Rhodophyceae, Ceramiales, Rhodomelaceae). Aust J Chem 42:1591-1603 ... Davyt D, Fernandez R, Suescun L, Mombrú AW, Saldaña J, Domínguez L, Coll J, Fujii MT, Manta E (2001) New sesquiterpene ... Kamada T, Vairappan CS (2017) Non-halogenated new sesquiterpenes from Bornean Laurencia snackeyi. Nat Prod Res 31:333-340 ...
Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase ... together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine ...
This sesquiterpene is a common volatile compound emitted from flowers, and is a major volatile released from the stigma of ... The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a ...
Sesquiterpene alkaloids (1-3) were isolated from N. japonicum and dimeric sesquiterpene thioalkaloids (4-10) were isolated from ... Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines M. Fukaya, S. ... Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines ...
What is C-15 sesquiterpene? Meaning of C-15 sesquiterpene medical term. What does C-15 sesquiterpene mean? ... Looking for online definition of C-15 sesquiterpene in the Medical Dictionary? C-15 sesquiterpene explanation free. ... redirected from C-15 sesquiterpene). Also found in: Dictionary. ar·te·mis·i·nin. (arte-misin-in), A sesquiterpene ... C-15 sesquiterpene , definition of C-15 sesquiterpene by Medical dictionary https://medical-dictionary.thefreedictionary.com/C- ...
The sesquiterpene lactone britannin was isolated from the above extract. This was further evaluated in the MTT assay to ...
description.provenance : Made available in DSpace on 2013-10-08T19:48:08Z (GMT). No. of bitstreams: 1 ThomasJamesAnthony1979.pdf: 1058611 bytes, checksum: e26f85e6720f24511b55bb3d6e712fa3 (MD5) Previous issue date: 1979-03- ...
... a sesquiterpene cyclase, were isolated from tissue cultures of Aquilaria microcarpa, and data mining analysis of the ... exhibited the catalytic activities of sesquiterpene biosynthesis. Among these three δ-guaiene synthases, two isoforms were ... acid residues at C-terminal of the synthase protein are essential to exhibit the catalytic activities as the sesquiterpene ... "Cloning and Characterization of δ-Guaiene Synthase Genes Encoding a Sesquiterpene Cyclase from Aquilaria microcarpa Cell ...
Southwell, Ian A. and Tucker, David J. (1993). SESQUITERPENE ETHERS FROM AUSTRALIAN MINTBUSH. Acta Hortic. 344, 428-433. DOI: ... Ethanolic extract screening of populations established that sesquiterpene ether content was related to geographic location. ... kessane and a novel C15H26O sesquiterpene. The latter gave (+)-. -selinene on treatment with trimethyliodosilane. COSY, FLOCK ...
Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana ... TransmissionPlant ExtractsSesquiterpenesSesquiterpenes, GermacraneTrypanosoma cruzi ... The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer ... Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma ...
Preventive and therapeutic anti-inflammatory properties of the sesquiterpene alpha-humulene in experimental airways allergic ... alpha-Humulene and trans-caryophyllene are plant sesquiterpenes with pronounced anti-inflammatory properties. Here, we ...
Q55012) (8) identified putative sesquiterpene synthases in a number of bacterial sequences (Fig. 2). Sesquiterpene synthase ... Structural identification of the NP1 sesquiterpene product.The unidentified sesquiterpene synthesized by NP1 was then ... Identification of Sesquiterpene Synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. Strain PCC 7120 Sean A. Agger, ... Sesquiterpene synthases from Streptomyces have been shown to produce pentalenene (8), epi-isozizaene (33), and geosmin (9, 26 ...
Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial. Gilboé L. Mendes, Adair R. S. Santos, ... Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial. Gilboé L. Mendes, Adair R. S. Santos, ... Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial. Gilboé L. Mendes, Adair R. S. Santos, ... Polygodial, a sesquiterpene isolated from the bark ofDrymis winteri given systemically, intraplantarly, or by spinal or ...
The synthesized indole sesquiterpenes 7, 11 and 12 show cellular proliferation inhibition of a number of human leukaemic and ... Biomimetic synthesis of an antitumour indole sesquiterpene alkaloid, 12-epi-ent-pentacyclindole. ...
  • Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. (wikipedia.org)
  • Sesquiterpene lactones (SLs) are a class of sesquiterpenoids that contain a lactone ring. (wikipedia.org)
  • Some plants containing these compounds include: Artichoke Boneset Eupatorium perfoliatum Burdock Calea ternifolia Chamomile Chrysanthemum Cocklebur Feverfew Gaillardia Ginkgo biloba Laurus nobilis Lettuce (Lactuca) Marsh elder Mugwort Parthenium Poverty weed Pyrethrum Ragweed Sagebrush Sneezeweed Spinach Star anise Sunflower Ironweed Wormwood Yellow star thistle bitter leaf Quorum sensing inhibitors Sesquiterpene lactones have been found to possess the ability to inhibit quorum sensing in bacteria. (wikipedia.org)
  • What Made Sesquiterpene Lactones Reach Cancer Clinical Trials? (wikipedia.org)
  • Big Sagebrush ( Artemisia tridentata ) contains sesquiterpene lactones which are sesquiterpenoids (built from three isoprene units) and contain a lactone ring, hence the name. (rug.nl)
  • The different skeletal types of sesquiterpene lactones (SLs) are classified on the basis of their carbocyclic ring skeleton, in which the suffix "olide" is used to indicate the presence of a lactone group. (springer.com)
  • 1979. The biogenesis and chemistry of sesquiterpene lactones. (springer.com)
  • Sesquiterpene lactones as characters in the Asteraceae. (springer.com)
  • 1986. Sesquiterpene lactones of the Umbelliferae. (springer.com)
  • Sesquiterpene lactones in the Compositae. (springer.com)
  • Intraspecific variation of sesquiterpene lactones in Ambrosia (Compositae). (springer.com)
  • Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. (hindawi.com)
  • Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. (hindawi.com)
  • Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation. (hindawi.com)
  • Sesquiterpene lactones (SLs) are probably the largest class of secondary metabolites in plants, with over 5000 structures reported to date [ 1 - 4 ]. (hindawi.com)
  • Sesquiterpene lactones are bitter, colourless substances, with lipophilic character and a variety of structural arrangements. (hindawi.com)
  • Sesquiterpene lactones play an important role in communication between plants and interaction with insects, microorganism, and animals acting as attractants, deterrents, and antifeedants [ 1 , 8 , 9 ]. (hindawi.com)
  • One plant species usually produces one type of sesquiterpene lactones, found chiefly in leaves and flowers in concentrations of 0.01% to 8% dry weight [ 5 , 10 ]. (hindawi.com)
  • Summary of HPLC conditions for sesquiterpene lactones. (hindawi.com)
  • Bioassay-guided chromatographic fractionation of the dichloromethane extract led to the isolation and identification of six elemanolide type sesquiterpene lactones: 8-desacylvernolide, vernolepin, vernomenin, vernodalol, vernodalin and 11,13-dihydrovernodalin. (mdpi.com)
  • All these elemanolide sesquiterpene lactones showed in vitro anti-trypanosomal activity. (mdpi.com)
  • In this study, we evaluated the activity of enhydrin, uvedalin and polymatin B, three sesquiterpene lactones (STLs) isolated from Smallanthus sonchifolius, on Leishmania mexicana (MNYC/BZ/62/M) and Trypanosoma cruzi (Dm28c). (unboundmedicine.com)
  • In the present chapter, we review some aspects of the biosynthesis of sesquiterpene lactones and its regulation in different medicinal and aromatic plants used in the pharmaceutical industry. (springer.com)
  • This metabolic pathway has become a model system not only for the biotechnological production of sesquiterpene lactones but also for the improvement of other plant secondary metabolic pathways. (springer.com)
  • The Andes-endemic Barnadesioideae lineage is the oldest surviving and phylogenetically basal subfamily of the Asteraceae (Compositae), a prolific group of flowering plants with world-wide distribution (~24,000 species) marked by a rich diversity of sesquiterpene lactones (STLs). (jic.ac.uk)
  • Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. (csir.co.za)
  • article{Ghantous2010WhatMS, title={What made sesquiterpene lactones reach cancer clinical trials? (semanticscholar.org)
  • Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional medicine against inflammation and cancer. (semanticscholar.org)
  • Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides. (semanticscholar.org)
  • Sesquiterpene Lactones, Acyl Phenyl Propanoids and Other Constituents from Schkuhria pinnata var. (scielo.org.mx)
  • north to south) and climatic gradient in Germany, flowerheads of Arnica montana were collected, and the total content of sesquiterpene lactones (SLs) as well as the content of the detected single compds. (uni-regensburg.de)
  • Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that consist of sesquiterpenoids and lactone ring as pharmacophore moiety. (eurekaselect.com)
  • Asteraceae family based medicinal plants, from which more than 5,000 sesquiterpene lactones have been reported so far. (eurekaselect.com)
  • Recently, outlook of sesquiterpene lactones as phytomedicine has been increased. (eurekaselect.com)
  • This study will be reviewed the future prospect of sesquiterpene lactones against inflammation and cancer. (eurekaselect.com)
  • Furthermore, the corelation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well. (eurekaselect.com)
  • Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases. (eurekaselect.com)
  • Siyuan Zhang, Yen-Kim Won, Choon-Nam Ong and Han-Ming Shen, " Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms", Current Medicinal Chemistry - Anti-Cancer Agents (2005) 5: 239. (eurekaselect.com)
  • Sesquiterpenes lactones including costunolide and dehydrocostus lactone, were isolated from Saussurea lappa roots, which had exhibited a wide range of biological activities such as anti-cancer, anti-inflammatory, antiulcer, and immunomodulatory activities. (ac.ir)
  • High-speed counter-current chromatography (HSCCC) was applied for the rapid preparative isolation of sesquiterpenes lactones from Saussurea lappa roots. (ac.ir)
  • Sesquiterpene lactones, constituents of plants of the family Compositae, are one of the largest classes of naturally occurring organic compounds. (kzoo.edu)
  • The germacranolides are one of the largest classes of the sesquiterpene lactones. (kzoo.edu)
  • However, if this were the only mode of action at work, then all of the sesquiterpene lactones should have the same amount of activity. (kzoo.edu)
  • Using molecular modeling the structures of the eight conformational isomers of the germacranolide sesquiterpene lactones were built and analyzed. (kzoo.edu)
  • In order to look for lower toxic and strongly active compounds, the structure of sesquiterpene lactones from Elephantopus scaber was modified. (bvsalud.org)
  • From the most active time window, three guaianolides (1, 2, and 5) and two seco-tanapartholides (3 and 4) were identified and, in a less active time window, five new sesquiterpene lactones (8-11, 17), along with six known sesquiterpene lactones and two known flavonoids. (unibas.ch)
  • Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants and found to have potential anticancer activities. (oncotarget.com)
  • A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known germacranolide sesquiterpene lactones, leucanthin-A (2), leucanthin-B (3), melampodin-A acetate (4), and 3α-hydroxyenhydrin (5). (utmb.edu)
  • Sesquiterpene lactones from the aerial parts of Anthemis arvensis L. (elsevier.com)
  • Two known sesquiterpene lactones, antheindurolides A and B, together with five new related lactones with the same unusual skeleton were isolated from the aerial parts of Anthemis arvensis growing in Serbia. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Sesquiterpene lactones from the aerial parts of Anthemis arvensis L.'. Together they form a unique fingerprint. (elsevier.com)
  • Sesquiterpene lactones from the aerial parts of Anthemis arvensis L. Biochemical Systematics and Ecology , 34 (4), 303-309. (elsevier.com)
  • Sesquiterpene lactones of amphoricarpos autariatus ssp. (ac.rs)
  • The LC-ESI MS and 1H NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. (ac.rs)
  • CMU Intellectual Repository: γ-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. (cmu.ac.th)
  • Psilostachyin and psilostachyin C, two sesquiterpene lactones isolated from Ambrosia spp. (conicet.gov.ar)
  • Considering both the potential therapeutic targets present in the parasite, and the several mechanisms of action proposed for sesquiterpene lactones, the aim of this work was to characterize the mode of action of psilostachyin and psilostachyin C on Trypanosoma cruzi and to identify the possible targets for these molecules. (conicet.gov.ar)
  • Interaction of sesquiterpene lactones with hemin, the induction of oxidative stress, the inhibition of cruzi-pain and trypanothione reductase and their ability to inhibit sterol biosynthesis were evaluated. (conicet.gov.ar)
  • Both sesquiterpene lactones induced parasite death by apoptosis. (conicet.gov.ar)
  • Despite their structural similarity, both sesquiterpene lactones exerted their anti-T. cruzi activity through interaction with different targets. (conicet.gov.ar)
  • Four sesquiterpene lactones have been isolated from the ethyl acetate soluble fraction of Amberboa ramosa . (biomedcentral.com)
  • A new sesquiterpene lactone has been isolated and fully characterized, the sesquiterpene lactones from Amberboa ramosa showed good inhibitory activities against acetyl cholinesterase and butyryl cholinesterase enzymes, this study indicated that sesquiterpene lactone can become interesting lead molecules in drug development against Alzheimer's disease (AD). (biomedcentral.com)
  • abstract = "Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep. (elsevier.com)
  • abstract = "Sesquiterpenes, arecoic acids A-F and arecolactone, were isolated from the ethyl acetate extracts of the fermented broth of Arecophila saccharicola YMJ96022401 along with two known analogues 1,7α,10α- trihydroxyeremophil-11(13)-en-12,8-olide and 1,10α,13-trihydroxyeremophil- 7(11)-en-12,8-olide. (elsevier.com)
  • Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. (wikipedia.org)
  • Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C 15 H 24 . (rug.nl)
  • These compounds are dominated by two major biosynthetic groups: terpenes (sesquiterpenes, diterpenes, and triterpenes) and C 15 -acetogenins. (springer.com)
  • Of the volatile terpenes-isoprene (C 5 ), monoterpenes (C 10 ), sesquiterpenes (C 15 ), and a few homoterpenes (C 11 and C 16 ) derived from the degradation of sesquiterpenes and diterpenes-sesquiterpenes and their derivatives are the most diverse, with approximately 5,000 structures ( Seigler, 2014 ). (plantphysiol.org)
  • There are other names used to describe terpenes, such as monoterpenes and sesquiterpenes. (terpenesandtesting.com)
  • These in turn are produced by a diverse range of sesquiterpene synthases. (wur.nl)
  • In addition, putative terpene synthase sequences were obtained from various resources and compared with the annotated sesquiterpene synthases. (wur.nl)
  • Identification of Sesquiterpene Synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. (asm.org)
  • Here, we describe the characterization of three sesquiterpene synthases identified in Nostoc sp. (asm.org)
  • The second terpene synthase in N. punctiforme (NP2) is homologous to fusion-type sesquiterpene synthases from Streptomyces spp. (asm.org)
  • Sesquiterpene synthases catalyze the cyclization of FPP into any of 300 known hydrocarbon skeletons. (asm.org)
  • Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an α-eudesmol synthase. (bioportfolio.com)
  • This study describes the discovery of three novel sesquiterpene synthases from Streptomyces chartreusis with preference for the formation of germacradiene-11-ol, α-eudesmol and α-amorphene respectively. (bioportfolio.com)
  • Discovery of germacrene A synthases in Barnadesia spinosa: The first committed step in sesquiterpene lactone biosynthesis in the basal member of the Asteraceae. (jic.ac.uk)
  • These hypotheses have often been tested by transforming plants with sesquiterpene synthases expressed behind the constitutively active 35S promoter, which may have physiological costs measured as inhibited growth and reduced reproduction or may require augmentation of substrate pools to achieve enhanced emission, complicating the interpretation of data from affected transgenic lines. (plantphysiol.org)
  • In order to better understand the influence of sesquiterpene synthases on artemisinin yield in Artemisia annua, the expression of some sesquiterpene synthases has been studied using transgenic plants expressing promoter-GUS fusions. (diva-portal.org)
  • Transgenic A. annua plants carrying promoter-GUS fusions were studied to elucidate the expression pattern of the three sesquiterpene synthases and compared to the previously studied promoter of amorpha-4,11-diene synthase (ADS), a key enzyme of artemisinin biosynthesis. (diva-portal.org)
  • The four sesquiterpene synthases may be involved in responsiveness of A. annua to herbivory. (diva-portal.org)
  • Methyl jasmonate treatment triggered activation of the promoters of all four sesquiterpene synthases in a time depended manner. (diva-portal.org)
  • The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. (wikipedia.org)
  • Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase. (bioportfolio.com)
  • In this sense, we describe the mevalonate and the 2- C -methyl-D-erythritol 4-phosphate pathways, which generate the corresponding isoprenoid precursors (isopentenyl diphosphate and dimethylallyl diphosphate), as well as the late pathways that lead to sesquiterpene lactone biosynthesis. (springer.com)
  • This chapter also analyses the role of the transcription factors involved in the regulation of sesquiterpene lactone biosynthesis and the different biotechnological approaches that have been developed for sesquiterpene lactone production. (springer.com)
  • The largest metabolic sink for products of the MVA pathway is sterol biosynthesis ( Rodríguez-Concepción, 2006 ), but substrate from the MVA pathway also provides precursors of sesquiterpene volatiles as well as signaling molecules, such as cytokinins and brassinosteroids, and prenyl moieties for protein modification among other things. (plantphysiol.org)
  • Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum. (lu.se)
  • A gene cluster, including a putative sesquiterpene 1-11 cyclase, was identified through phylogenetic and RNA-seq analysis , and is proposed to be responsible for the biosynthesis of 1 and 2. (bvsalud.org)
  • To gain a better understanding of the regulation of artemisinin biosynthesis, this project was designed to clone several fragments encoding putative sesquiterpene cyclases. (wpi.edu)
  • A sesquiterpene cyclase in Tripterygium wilfordii (TwCS) was determined to directly catalyze ( E , E )-farnesyl pyrophosphate (FPP) to unexpected eudesmane diols, primarily cryptomeridiol. (portlandpress.com)
  • Sesquiterpene cyclase, a branch point enzyme in the general isoprenoid pathway for the synthesis of phytoalexin capsidiol, was induced in detached leaves of Capsicum annuum (pepper) by UV treatment. (oup.com)
  • The inducibility of cyclase enzyme activities paralleled the absolute amount of cyclase protein(s) of pepper immunodetected by monoclonal antibodies raised against tobacco sesquiterpene cyclase. (oup.com)
  • A cDNA clone for sesquiterpene cyclase in pepper was isolated by using a tobacco 5-epi aristolochene. (oup.com)
  • A cDNA clone for sesquiterpene cyclase in pepper was isolated by using a tobacco 5-epi aristolochene synthase gene as a hetero-logous probe. (oup.com)
  • The analyses of these fragments showed regions of high homology to sesquiterpene cyclase genes and other regions of very low homology. (wpi.edu)
  • To address this, we have gathered 262 plant sesquiterpene synthase sequences with experimentally characterized products. (wur.nl)
  • This demonstrates an application of our database in choosing likely-functional residues for mutagenesis studies aimed at understanding or changing sesquiterpene synthase product specificity. (wur.nl)
  • It has been assumed [2] that guaianolide sesquiterpenes are synthesized via two steps of cyclization reactions catalyzed by δ-guaiene synthase (GS) with farnesyl diphosphate (FPP) as the substrate ( Figure 1 ). (scirp.org)
  • report how a sesquiterpene synthase generates eudesmane-type sesquiterpene diols in Tripterygium wilfordii and which residues are important for cyclization. (portlandpress.com)
  • Transcript profiling of seedlings and adult plant roots inoculated with A. euteiches zoospores for 2 h revealed specific upregulation of a gene encoding a putative sesquiterpene synthase ( M. truncatula TERPENE SYNTHASE 10 [MtTPS10]) in both developmental stages. (plantphysiol.org)
  • Moreover, plants carrying a tobacco ( Nicotiana tabacum ) retrotransposon Tnt1 insertion in MtTPS10 lacked the emission of sesquiterpenes upon A. euteiches infection, supporting the assumption that the identified gene encodes a multiproduct sesquiterpene synthase. (plantphysiol.org)
  • The monoterpene, and particularly the sesquiterpene composition of olive oil may be used to distinguish samples from different cultivar and geographical areas. (csic.es)
  • Secondary organic aerosol from sesquiterpene and monoterpene emissions in the United States. (escholarship.org)
  • This means within 20 minutes you have some Sesquiterpene, Phenol, and Monoterpene goodness in every cell in your body, working on the receptor sites that need help. (juniperandco.com)
  • These tissues produce a variety of sesquiterpene compounds with aroma such as δ-guaiene, α-guaiene and α-humulene, and, therefore, they have been used as a scent, perfume and traditional medicines. (scirp.org)
  • Predicted biosynthetic pathway of guaiene-type sesquiterpene compounds of Aquilaria plants. (scirp.org)
  • Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells. (semanticscholar.org)
  • Sesquiterpenes are non- polar compounds, which oxidize more slowly than monoterpenes. (theoilacademy.com)
  • A new sesquiterpene polyol ester with a beta-dihydroagarofuran skeleton, NW37 (1), and three known compounds NW13 (2), NW16 (3) and NW35 (4) were isolated by bioassay-guided fractionation from the highly polar MeOH extracts of the root bark of Celastrus angulatus. (scholarmate.com)
  • A pale yellow liquid, cannabis flower essential oil is a volatile oil that is a mixture of monoterpenes , sesquiterpenes , and other terpenoid compounds. (wikipedia.org)
  • has furnished a DNA-damaging sesquiterpene, costunolide (1), and two inactive compounds, a sesquiterpene (-)-frullanolide (2) and a tridepside tenuiorin (3). (elsevier.com)
  • Among these compounds, 1,7α,10α-trihydroxyeremophil-11(13)-en-12,8-olide significantly inhibited NO production without any cytotoxicity, and its average maximum inhibition (E max ) at 100 μM and median inhibitory concentration (IC 50 ) were 85.7% ± 0.8% and 16.5 ± 1.0 μM, respectively. (elsevier.com)
  • Artemisinin, a new, highly-effective anti-malarial compound, is a sesquiterpene lactone found in Artemisia annua. (wikipedia.org)
  • In the current study, we report that EM23, a natural sesquiterpene lactone isolated from EM, inhibits the proliferation of human chronic myeloid leukemia (CML) K562 cells and acute myeloid leukemia (AML) HL-60 cells by inducing apoptosis. (frontiersin.org)
  • This being a chemistry made simple class, I'm going to go over the 3 most commonly seen constituents: Monoterpenes, Sesquiterpenes and Phenols and talk about some of the favorite oils that contain large amounts of those constituents. (theoilacademy.com)
  • The 57 identified constituents were 92% monoterpenes, 7% sesquiterpenes, and approx. (wikipedia.org)
  • Kingston, David G.I. / A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis . (elsevier.com)
  • The characterisation and isolation of genes involved in the regulation of sesquiterpene lactone biosynthetic pathways have allowed the design of metabolic engineering strategies to increase the production of these metabolites. (springer.com)
  • The present study aims to evaluate the suitability of sesquiterpene hydrocarbon (SH) fingerprint as VOO cultivar marker beyond geographical, agronomical and processing conditions. (ub.edu)
  • Sesquiterpene molecules deliver oxygen molecules to cells, like hemoglobin does in the blood. (theoilacademy.com)
  • At the same time the oxygen carried by sesquiterpene molecules creates an environment where cancer cells can't reproduce. (theoilacademy.com)
  • The agents, of course, are essential oils-particularly those containing the brain oxygenating molecules of sesquiterpenes. (theoilacademy.com)
  • ISBN 978-3-540-66573-1.CS1 maint: uses authors parameter (link) Chizzola R (2013), "Regular Monoterpenes and Sesquiterpenes (Essential Oils)", Natural Products, Springer Berlin Heidelberg, pp. 2973-3008, doi:10.1007/978-3-642-22144-6_130, ISBN 9783642221439 Izaguirre G, Taylor WD (June 1995). (wikipedia.org)
  • Plants exhibit a vast array of sesquiterpenes, C15 hydrocarbons which often function as herbivore-repellents or pollinator-attractants. (wur.nl)
  • The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a defense against a bacter. (nih.gov)
  • The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a defense against a bacterial pathogen. (nih.gov)
  • This sesquiterpene is a common volatile compound emitted from flowers, and is a major volatile released from the stigma of Arabidopsis thaliana flowers. (nih.gov)
  • In general, sesquiterpenes are colorless, are insoluble in water and are more aromatic, less volatile and have higher boiling points than monoterpenes. (theoilacademy.com)
  • Monoterpenes are often more volatile than sesquiterpenes. (terpenesandtesting.com)
  • Kamada T, Vairappan CS (2015) New laurene-type sesquiterpene from Bornean Laurencia nangii . (springer.com)
  • Cloning and sequencing of putative sesquiterpene DNA and cDNA fragments. (wpi.edu)
  • A new tricyclic sesquiterpene amide, pinthunamide, has been isolated from a fungus, Ampulliferina sp. (elsevier.com)
  • Let's talk about Sesquiterpenes, Phenols, and Monoterpenes. (juniperandco.com)
  • Monoterpenes restore the correct information in the DNA of the cell once the Sesquiterpenes and Phenols have done their job. (juniperandco.com)
  • From our efforts to identify antifungal agents from marine organisms, we have isolated and identified (+)-curcuphenol [1] and (+)-curcudiol [2] two sesquiterpene phenols, from both deep and shallow water collections of the sponge Didiscus flavus van Soest (fam. (flvc.org)
  • Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for their cholinesterase inhibitory activity. (biomedcentral.com)
  • Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. (wikipedia.org)
  • These results clearly indicate that mevalonate pathway-engineered E. coli cells showed an appreciable δ-guaiene producing activity in the en- riched medium in the presence of appropriate isoprene precursors. (scirp.org)
  • Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. (wikipedia.org)
  • We found that maize plants that were exposed to GLVs emitted increased quantities of sesquiterpenes compared to non-exposed plants. (rero.ch)
  • Transgenic N. attenuata plants had specifically enhanced emission of target sesquiterpene(s) with no changes detected in their emission of any other volatiles. (plantphysiol.org)
  • Ectopic sesquiterpene emission was apparently not costly for transgenics, which were similar to wild-type plants in their growth and reproduction, even when forced to compete for common resources. (plantphysiol.org)
  • Sesquiterpenes have only recently been quantified in emissions from a wide variety of plants. (escholarship.org)
  • The stem bark was extracted with dichloromethane followed by silica gel column chromatography that led to the isolation of iso-mukaadial acetate, a drimanoid sesquiterpene. (biomedcentral.com)
  • together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. (go.jp)
  • The present research deals with the multi-collection of the most important sesquiterpene alcohols belonging to sandalwood essential oil, as reported by the international regulations: (Z)-α-santalol, (Z)-α-trans bergamotol, (Z)-β-santalol, epi-(Z)-β-santalol, α-bisabolol, (Z)-lanceol, and (Z)-nuciferol. (scoop.it)
  • Heterologous expression of MtTPS10 in yeast led to production of a blend of sesquiterpenes and sesquiterpene alcohols, with NMR identifying a major peak corresponding to himalachol. (plantphysiol.org)
  • Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro. (greenmedinfo.com)
  • Root volatiles in plant-plant interactions I: High root sesquiterpene release is associated with increased germination and growth of plant neighbors. (bioportfolio.com)
  • Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. (strath.ac.uk)
  • Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri. (bvsalud.org)
  • Hong and Tantillo 1 report a real tour de force computational study of multiple pathways along the routes towards synthesis of a variety of sesquiterpenes. (comporgchem.com)
  • Two dimeric sesquiterpenes , bovistol B (1) and D (2), and one monomeric sesquiterpene , strossmayerin (7), were isolated from the culture filtrate of the basidiomycete fungus Coprinopsis strossmayeri. (bvsalud.org)
  • Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. (nih.gov)
  • Helenalin, a sesquiterpene lactone has been demonstrated to have potent anti-inflammatory and antitumor activity. (biomedcentral.com)
  • In this regard, helenalin, a naturally occurring sesquiterpene lactone has generally been considered as a distinctly promising and potent antitumor compound. (biomedcentral.com)
  • As the anti cholinesterase activity of chloroform soluble fraction from Amberboa ramosa has previously been reported [ 3 ], keeping in view this point we evaluated the guaianolides (sesquiterpenes) isolated from chloroform soluble fraction of Amberboa ramosa for their cholinesterase inhibitory activity. (biomedcentral.com)
  • Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography', Iranian Journal of Pharmaceutical Research , 18(3), pp. 1499-1507. (ac.ir)
  • This transformant was capable of liberating an appreciable amount of δ-guaiene, an aroma sesquiterpene compound accumulated in agarwood, and its concentration was elevated to more than 30 μg/ml culture by the incubation with mevalonolactone as an isoprene precursor in a nutrient-enriched Terrific broth. (scirp.org)
  • In this study we have isolated four guaianolides (sesquiterpenes) out of which Amberbin C ( 1 ) was identified as a new compound while other three Amberin ( 2 ) [ 6 ], Amberbin A ( 3 ) and Amberbin B ( 4 ) [ 7 ] were previously been reported from the same source. (biomedcentral.com)
  • Ethanolic extract screening of populations established that sesquiterpene ether content was related to geographic location. (ishs.org)
  • Sesquiterpenes produced by expression of MtTPS10 in yeast also inhibited mycelial growth and A. euteiches zoospore germination. (plantphysiol.org)