AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
SesquiterpenesSesquiterpenes, GermacraneSesquiterpenes, GuaianeSesquiterpenes, EudesmaneCelastraceaeZingiberaceaeOils, VolatileAsteraceaeIlliciumEuonymusMonoterpenesThymelaeaceaeDrimysPulicariaTerpenesRhizomeValerianLinderaInulaMagnoliaceaeEremophila PlantPlant ExtractsChrysanthemumCurcumaVolatilizationActinidiaAlkyl and Aryl TransferasesXylarialesLaurenciaMagnetic Resonance SpectroscopyCryptomeriaMembrane Transport ModulatorsSpectrophotometry, InfraredCupressaceaeSalviaApiaceaeVolatile Organic CompoundsLippiaDendrobiumSpectrometry, Mass, Fast Atom BombardmentMolecular StructurePlant BarkGas Chromatography-Mass SpectrometryPolyisoprenyl PhosphatesPlant LeavesLactonesPlant Components, AerialSpectrophotometry, UltravioletSpectrometry, Mass, Electrospray IonizationPlant OilsPlant RootsPlants, MedicinalPhotoaffinity LabelsMolecular ConformationNuclear Magnetic Resonance, BiomolecularFungiDrug Screening Assays, AntitumorAntineoplastic Agents, PhytogenicSpectroscopy, Fourier Transform InfraredFruitMass SpectrometryStereoisomerismChromatography, High Pressure Liquid
Sesquiterpenes
Sesquiterpenes, Germacrane
SESQUITERPENES cyclized to one 10-carbon ring.
Sesquiterpenes, Guaiane
SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.
Sesquiterpenes, Eudesmane
SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.
Celastraceae
A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.
Zingiberaceae
A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).
Oils, Volatile
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Asteraceae
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Illicium
A plant genus of the family Illiciaceae, order Illiciales, subclass Magnoliidae, class Magnoliopsida. They have evergreen, aromatic leaves and bisexual flowers. The female portion of the flower consists of 7 to 15 carpels.
Euonymus
A plant genus of the family CELASTRACEAE.
Monoterpenes
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Thymelaeaceae
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.
Drimys
A plant genus of the family WINTERACEAE. They have leathery, elliptic-shaped leaves; red-tinged shoots; and jasmine-scented, cream-colored, 8- to 12-petaled, 2.5-centimeter (1-inch) flowers in clusters.
Pulicaria
A plant genus of the family ASTERACEAE. Members contain pulicanadienes and other cytotoxic SESQUITERPENES.
Terpenes
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
Rhizome
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
Valerian
A plant genus of the family VALERIANACEAE, order Dipsacales, subclass Asteridae, class Magnoliopsida. It is best known for the sedative use and valepotriate content of the roots. It is sometimes called Garden Heliotrope but is unrelated to true Heliotrope (HELIOTROPIUM).
Lindera
A plant genus in the LAURACEAE family. Lindera benzoin is a source of a balsamic resin called benzoin which is up to 1/3 BENZOIC ACID. This should not be confused with the chemical BENZOIN or the plant STYRAX BENZOIDES.
Inula
A plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.
Magnoliaceae
A plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. They are trees and shrubs having an elongated conelike floral axis with fragrant flowers that have six tepals (sepals and petals that are not distinctly different) and many spirally arranged stamens.
Eremophila Plant
A plant genus of the family MYOPORACEAE. Members have been used in FOLK MEDICINE.
Plant Extracts
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Chrysanthemum
A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.
Curcuma
A plant genus of the family ZINGIBERACEAE that contains CURCUMIN and curcuminoids.
Volatilization
A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.
Actinidia
A plant species of the family ACTINIDIACEAE, order Theales.
Alkyl and Aryl Transferases
A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.
Xylariales
An order of ascomycetous FUNGI which includes many economically important plant parasites as well as saprophytes.
Laurencia
A genus of RED ALGAE in the family Rhodomelaceae. Some species are a rich source of chlorine-and bromine-containing metabolites which show significant antibacterial activity.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Cryptomeria
A plant genus of the family TAXODIACEAE. Its POLLEN is one of the major ALLERGENS.
Membrane Transport Modulators
Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS.
Spectrophotometry, Infrared
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Cupressaceae
A plant family of the order Pinales, class Pinopsida, division Coniferophyta (conifers). They are mainly resinous, aromatic evergreen trees.
Salvia
A genus in the mint family (LAMIACEAE).
Apiaceae
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
Volatile Organic Compounds
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
Lippia
A plant genus of the family VERBENACEAE. Lippsidoquinone; TRITERPENES; SESQUITERPENES; and THYMOL have been found in this genus. Plant extracts have cytotoxic activity. It is sometimes called Mexican oregano but that confuses it with real oregano (ORIGANUM).
Dendrobium
A plant genus of the family ORCHIDACEAE that contains dihydroayapin (COUMARINS) and phenanthraquinones.
Spectrometry, Mass, Fast Atom Bombardment
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Plant Bark
The outer layer of the woody parts of plants.
Gas Chromatography-Mass Spectrometry
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Polyisoprenyl Phosphates
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
Plant Leaves
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Lactones
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
Plant Components, Aerial
The above-ground plant without the roots.
Spectrophotometry, Ultraviolet
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Plant Oils
Oils derived from plants or plant products.
Plant Roots
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
Plants, Medicinal
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Photoaffinity Labels
Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.
Molecular Conformation
The characteristic three-dimensional shape of a molecule.
Nuclear Magnetic Resonance, Biomolecular
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Drug Screening Assays, Antitumor
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Antineoplastic Agents, Phytogenic
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Spectroscopy, Fourier Transform Infrared
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Fruit
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes. (1/2267)

Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.  (+info)

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (2/2267)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria. (3/2267)

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.  (+info)

Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. (4/2267)

6-Hydroxymethylacylfulvene (MGI-114) is a semisynthetic analogue of the toxin illudin S, a product of the Omphalotus mushroom. MGI-114 induces cytotoxicity in a variety of solid tumors in vivo, including the refractory HT29 human colon cancer xenograft. In this study, the potential application of MGI-114 in the treatment of colon cancer was further explored by evaluating the activity of MGI-114 in combination with irinotecan (CPT-11) and 5-fluorouracil (5FU). Groups of 9 nude mice bearing HT29 xenografts were treated with either single agent MGI-114, CPT-11, or 5FU, or MGI-114 in combination with CPT-11 or 5FU. MGI-114 was administered at doses of 3.5 and 7 mg/kg i.p. daily on days 1 through 5, and CPT-11 and 5FU were administered at doses of 50 and 100 mg/kg i.p. on days 1, 12, and 19. In the single agent studies, MGI-114, CPT-11, and 5FU all resulted in decreased final tumor weights compared with vehicle-treated controls (P<0.05), but only MGI-114 at 7 mg/kg produced partial responses. When MGI-114 at 3.5 mg/kg was combined with CPT-11, significant decrements in final tumor weights occurred compared with monotherapy with the same doses of MGI-114 and CPT-11 (P< or =0.001). Also, administration of the low-dose combination (MGI-114 at 35 mg/kg and CPT-11 at 50 mg/kg) resulted in final tumor weights similar to those achieved after administration of high-dose MGI-114 as a single agent. Moreover, the combination of MGI-114 and CPT-11 produced partial responses in nearly all of the animals, with some animals achieving complete responses. The outcome with the combination of MGI-114 and 5FU was less striking, with fewer partial responses and no complete responses. These results suggest enhanced activity when MGI-114 is combined with CPT-11, and clinical trials to further evaluate this combination regimen are planned.  (+info)

A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. (5/2267)

CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002). However, CGP 56697 was more effective than mefloquine in parasite clearance time (43 hr versus 66 hr; P < 0.001) fever clearance time (32 hr versus 54 hr; P < 0.005), and gametocyte clearance time (152 hr versus 331 hr; P < 0.001). This study revealed that CGP 56697 is effective against multidrug-resistant Plasmodium falciparum malaria in Thailand, but higher doses will probably be needed to improve the cure rate.  (+info)

The pharmacokinetics of artemisinin after administration of two different suppositories to healthy Vietnamese subjects. (6/2267)

Eight healthy Vietnamese male subjects received 400 mg artemisinin formulated into fatty suppositories (FS), and six different subjects received 500 mg of artemisinin formulated in polyethylene glycol suppositories (PEGS). Plasma concentrations were measured by high-performance liquid chromatography with electrochemical detection; concentration versus time curves were analyzed with nonparametric methods. No statistically significant differences were found between the two formulations. The maximum concentration (Cmax) was 100 +/- 102 microg/L (mean +/- SD, range = 24-330) microg/L (FS), the pharmacokinetic lag time (Tlag) was 1.3 +/- 1.0 hr (range = 0-3) (FS), and the time of the maximum concentration (Tmax) was 7.1 +/- 2.1 hr (range = 3-10) hr (FS). Because artemisinin is not available for intravenous dosage, absolute bioavailability cannot be assessed. However, compared with a previous study on oral artemisinin in healthy Vietnamese subjects, bioavailability relative to oral administration was estimated to be approximately 30%. We conclude that therapeutic blood concentrations of artemisinin can be reached after rectal dosage. The dose after rectal administration should probably be higher than after oral administration; doubling or tripling the oral dose might be necessary, which would imply a rectal dose of at least 20 mg/kg of body weight given twice a day.  (+info)

Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. (7/2267)

AIM: To compare the effects of huperzine A (Hup A), tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The miniature end-plate potentials (MEPP), the mean quantal content of end-plate potentials (EPP), and the resting membrane potentials of muscle fiber were recorded. RESULTS: Hup A, tacrine, and E2020 at the concentration of 1.0 mumol.L-1 increased the amplitude, time-to-peak, and half-decay time of MEPP in the potencies of E2020 > Hup A > tacrine. Hup A did not significantly change the frequency of MEPP, the appearance of giant MEPP or slow MEPP, the resting membrane potentials, and the mean quantal content of EPP. CONCLUSION: Hup A is a selective and potent cholinesterase inhibitor, by which activity it facilitates the cholinergic transmission at mouse neuromuscular junction, and devoid of pre- and post-synaptic actions.  (+info)

Effect of artemether on glucose uptake and glycogen content in Schistosoma japonicum. (8/2267)

AIM: To study the effect of artemether (Art) on glucose uptake and glycogen content in schistosomes. METHODS: Schistosomes recovered from mice treated intragastrically with Art 300 mg.kg-1 for 24-48 h, were incubated in the drug-free medium containing [U-14C]glucose 11.1 MBq.L-1. The glycogen content, [U-14C]glucose uptake, and incorporation of [U-14C]glucose into worm glycogen in both male and female worms were determined. RESULTS: When above-mentioned schistosomes were exposed to drug-free medium containing [U-14C]glucose for 1-24 h, the glycogen contents of male and female worms decreased 27%-61% and 39%-78%, respectively. Only 3 out of 6 male worm groups showed 23%-35% decrease in glucose uptake, while much less glucose uptake was found in female worms in all groups with reduction rates of 18%-38%. Apart from 2 male groups no apparent change in the incorporation of [U-14C]glucose into the worm glycogen was seen. CONCLUSIONS: Art-induced glycogen reduction in schistosomes was related to an inhibition of glycolysis rather than an interference with glucose uptake.  (+info)

Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.<...
TY - JOUR. T1 - Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.. AU - Emanuele, Sonia. AU - Lauricella, Marianna. AU - Di Fiore, Riccardo. AU - DAnneo, Antonella. AU - Vento, Renza. AU - Carlisi, Daniela. AU - Buttitta, Giuseppina. AU - Vento, Renza. AU - Tesoriere, null. AU - Tesoriere, Giovanni. PY - 2013. Y1 - 2013. N2 - The sesquiterpene lactone parthenolide (PN) has recently attracted considerable attention because of its anti-microbial, anti-inflammatory and anticancer effects. However, the mechanism of its cytotoxic action on tumor cells remains scarcely defined. We recently provided evidence that the effect exerted by PN in MDA-MB-231 breast cancer cells was mediated by the production of reactive oxygen species (ROS). The present study shows that PN promoted the phosphorylation of EGF receptor (phospho-EGFR) at Tyr1173, an event which was observed already at 1 h of incubation with 25 µM PN and reached a peak at 8-16 h. ...
https://pure.unipa.it/it/publications/parthenolide-induces-superoxide-anion-production-by-stimulating-e-3
Total synthesis of cis-Hydroazulene sesquiterpenes : base-induced and -directed elimination and rearrangement reactions of...
TY - THES. T1 - Total synthesis of cis-Hydroazulene sesquiterpenes : base-induced and -directed elimination and rearrangement reactions of perhydronaphthalene-1,4-diol monosulfonate esters. AU - Jenniskens, L.H.D.. N1 - WU thesis 1539 Proefschrift Wageningen. PY - 1992. Y1 - 1992. N2 - The total synthesis of a number of cis-fused hydroazulene sesquiterpenes is described in this thesis. In this synthetic study, ample attention is paid to the mechanistic aspects of the base- induced and -directed rearrangement and elimination reactions of perhydronaphthalene-1,4-diol monosulfonate esters. These reactions form the key steps in the synthetic routes that were followed.A general introduction into the chemistry of terpenes, with emphasis laid on the sesquiterpenes with a hydroazulene skeleton, is given in Chapter 1.In Chapter 2, an overview of the literature on the synthesis of these hydroazulene sesquiterpenes is presented. The different synthetic strategies towards the hydroazulene skeleton and their ...
https://research.wur.nl/en/publications/total-synthesis-of-cis-hydroazulene-sesquiterpenes-base-induced-a
Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice<...
TY - JOUR. T1 - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. AU - Shieh, Ying Hua. AU - Huang, Huei Mei. AU - Wang, Ching Chiung. AU - Lee, Chen Chen. AU - Fan, Chia Kwung. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the antiallergic activity and the underlying mechanism of zerumbone have not been reported. Herein, we investigated the immunomodulatory effects of zerumbone on antigen-presenting dendritic cells (DCs) in vitro and its potential therapeutic effects against ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T cell proliferation ...
https://tmu.pure.elsevier.com/zh/publications/zerumbone-enhances-the-th1-response-and-ameliorates-ovalbumin-ind
西力生物 - Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress....西力生物 - Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress....
Abstract: Sesquiterpene lactones have long been used in traditional Chinese medicines to treat inflammatory diseases. Recently, sesquiterpene lactone family compounds have been recognized as potential anticancer agents. Thus, it is necessary to explore new sesquiterpene lactones and their antitumor mechanism for cancer treatments. In the present study, we have explored the potential anti-cancer activity of a novel sesquiterpene lactone compound santamarine (STM) in HepG2 cells. It inhibited proliferation and induced apoptosis dose-dependently with IC50 ~ 70 μM. Induction of apoptosis was found to be linked with increased reactive oxygen species (ROS) generation, decreased activity of thioredoxin reductase (TrxR), glutathione (GSH) depletion, mitochondrial membrane potential (ΔΨm) dissipation, Bcl-2 family proteins modulation, cytochrome c release, caspases-9, -8 and -3 activation and PARP cleavage. Further mechanistic study demonstrated that STM inhibited the constitutive and TNF-α-induced ...
http://biobiopha.com/article/view/104
PLOS ONE: Beta-caryophyllene enhances wound healing through multiple routesPLOS ONE: Beta-caryophyllene enhances wound healing through multiple routes
Beta-caryophyllene is an odoriferous bicyclic sesquiterpene found in various herbs and spices. Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). Activation of CB2 will decrease pain, a major signal for inflammatory responses. We hypothesized that beta-caryophyllene can affect wound healing by decreasing inflammation. Here we show that cutaneous wounds of mice treated with beta-caryophyllene had enhanced re-epithelialization. The treated tissue showed increased cell proliferation and cells treated with beta-caryophyllene showed enhanced cell migration, suggesting that the higher re-epithelialization is due to enhanced cell proliferation and cell migration. The treated tissues also had up-regulated gene expression for hair follicle bulge stem cells. Olfactory receptors were not involved in the enhanced wound healing. Transient Receptor Potential channel genes were up-regulated in the injured skin exposed to beta-caryophyllene. Interestingly, there were sex
https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0216104.g010
Contribution to the elucidation of the anti-inflammatory activity of sesquiterpene lactones [Elektronische Ressource] /...Contribution to the elucidation of the anti-inflammatory activity of sesquiterpene lactones [Elektronische Ressource] /...
Contribution to the elucidation of the anti-inflammatory activity of sesquiterpene lactones [Elektronische Ressource] / vorgelegt von Alfonso J. García Piñeres : Contribution to the Elucidation of the Anti-inflammatory Activity of Sesquiterpene Lactones Inaugural-Dissertation zur Erlangung der Doktorwürde der Fakultät für Chemie, Pharmazie und Geowissenschaften der Albert-Ludwigs-Universität Freiburg im Breisgau vorgelegt von Alfonso J. García Piñeres aus San José, Costa Rica April 2003 Gedruckt mit Unterstützung
http://www.youscribe.com/catalogue/documents/savoirs/contribution-to-the-elucidation-of-the-anti-inflammatory-activity-of-1427777
Sesquiterpene - WikipediaSesquiterpene - Wikipedia
Sesquiterpenes are a class of terpenes that consist of three isoprene units and have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be acyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Oxidation of farnesene then provides sesquiterpenoids such as farnesol. There are more cyclic sesquiterpenes than cyclic monoterpenes because of the increased chain length and additional double bond. In addition to common six-membered ring systems such as is found in zingiberene (a constituent of the oil from ginger), cyclization of one end of the chain to the other end can ...
https://en.wikipedia.org/wiki/Sesquiterpene
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission |...The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission |...
Parthenin and parthenolide are natural products that are closely related in structure to artemisinin, which is also a sesquiterpene lactone (SQL) and one of the most important antimalarial drugs available. Parthenin, like artemisinin, has an effect onPlasmodiumblood stage development. We extended the evaluation of parthenin as a potential therapeutic for the transmissible stages ofPlasmodium falciparumas it transitions between human and mosquito, with the aim of gaining potential mechanistic insight into the inhibitory activity of this compound. We posited that if parthenin targets different biological pathways in the parasite, this in turn could pave the way for the development of druggable compounds that could prevent the spread of artemisinin-resistant parasites. We examined parthenins effect on male gamete activation and the ookinete-to-oocyst transition in the mosquito as well as on stage V gametocytes that are present in peripheral blood. Parthenin arrested parasite development for each ...
http://dinglasanlab.org/publications/nonartemisinin-sesquiterpene-lactones-parthenin-and-parthenolide-block-plasmodium?page=3
中国科学院昆明植物研究所机构知识库(KIB OpenIR): Sesquiterpenes and aliphatic diketones from cultures of the basidiomycete Conocybe siliginea中国科学院昆明植物研究所机构知识库(KIB OpenIR): Sesquiterpenes and aliphatic diketones from cultures of the basidiomycete Conocybe siliginea
Five new tremulane-type sesquiterpenes, 11,12-dihydroxy-1-tremulen-5-one (1), 11,12-epoxy-12 beta-hydroxy-1-tremulen-5-one (2), 5 alpha, 12-dihydroxy-1-tremulen-11-yl 2(S)-pyroglutamate (3), 2 alpha, 11-dihydroxy-1(10)-tremulen-5,12-olide (4), and 10 beta,11-dihydroxy-5,6-seco-1,6(13)-tremuladien-5,12-olide (5), as well as three new aliphatic diketones, 2,3-dihydroxydodecane-4,7-dione (9 and 10) and 1-hydroxydecane-2,5-dione (11), together with three known sesquiterpene analogues, tremulenediol A (6), conocenol B (7), and conocenolide A (8), were isolated from cultures of the basidiomycete Conocybe siliginea ...
http://ir.kib.ac.cn/handle/151853/1807
Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities<...Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities<...
TY - JOUR. T1 - Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities. AU - Robles, Andrew J.. AU - Peng, Jiangnan. AU - Hartley, Rachel M.. AU - Lee, Brigette. AU - Mooberry, Susan L.. PY - 2015/3/27. Y1 - 2015/3/27. N2 - A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known germacranolide sesquiterpene lactones, leucanthin-A (2), leucanthin-B (3), melampodin-A acetate (4), and 3α-hydroxyenhydrin (5). The chemical structure of 1 was elucidated by analysis of 1D and 2D NMR and mass spectrometric data. All compounds exhibited antiproliferative and cytotoxic efficacy against PC-3 and DU 145 prostate cancer cells, as well as HeLa cervical cancer cells, with IC50 values ranging from 0.18 to 9 μM. These compounds were effective in clonogenic assays and displayed high cellular persistence. They were also found to be capable of circumventing ...
https://researchexperts.utmb.edu/en/publications/melampodium-leucanthum-a-source-of-cytotoxic-sesquiterpenes-with-
Role of Phytoalexins in Plant Disease ResistanceRole of Phytoalexins in Plant Disease Resistance
Phytoalexins are low molecular weight antimicrobial compounds that are produced by plants as a response to biotic and abiotic stresses. The rapidity and extent of their accumulation is determined by their release of immediate precursors from conjugates or de novo synthesis, as well as detoxification as a result of plant or microbial enzymes. The rapidity of phytoalexin accumulation is associated with resistance in plants to diseases caused by fungi and bacteria, although the genetic information for phytoalexin synthesis is found in susceptible and resistant plants. Phytoalexins are only one component of the complex mechanisms for disease resistance in plants.
https://www.ijcmas.com/abstractview.php?ID=1282&vol=6-1-2017&SNo=16
中国科学院昆明植物研究所机构知识库(KIB OpenIR): New triquinane and gymnomitrane sesquiterpenes from fermentation of the basidiomycete...中国科学院昆明植物研究所机构知识库(KIB OpenIR): New triquinane and gymnomitrane sesquiterpenes from fermentation of the basidiomycete...
Five new triquinane-type sesquiterpenes, antrodins A-E (1-5) and a new gymnomitrane sesquiterpene, antrodin F (6), together with three known compounds 7-9 were isolated from fermentation of Antrodiella albocinnamomea. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 and 6 were determined using single-crystal X-ray diffraction analyses. The isolated compounds were investigated for their cytotoxicities against five human cancer cell lines. (C) 2015 Elsevier B.V. All rights reserved ...
http://ir.kib.ac.cn/handle/151853/20684
Ċina Psoralen, Terpenoids, Glycosides, Sesquiterpenes, pjanti estratt manifatturi u provdituri - Baoji Herbest Bio bpotenzal...
Jekk inti qed jippjanaw li terpenoids bl-ingrossa, glycosides, sesquiterpenes, estratt tal-pjanti minn wieħed mill-fabbrikanti ta l-psoralen Ċina professjonali u fornituri, Nitolbok li tħossok liberu li tikkuntattja Baoji Herbest Bio bpotenzal Co., Ltd.
http://m.mt.bjherbest.com
KEGG PATHWAY: ec00909
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids ...
http://www.genome.jp/dbget-bin/www_bget?pathway+ec00909
KEGG PATHWAY: ko00909
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids ...
http://www.genome.jp/dbget-bin/www_bget?ko00909
parthenolide | Definition of parthenolide in US English by Oxford Dictionariesparthenolide | Definition of parthenolide in US English by Oxford Dictionaries
Definition of parthenolide in US English - A sesquiterpene lactone, C₁₅H₂₀O₃, with antibacterial and cytotoxic properties which is the active ingredient in prepara
https://en.oxforddictionaries.com/definition/us/parthenolide
pyripyropene A | Semantic Scholarpyripyropene A | Semantic Scholar
A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which… Expand ...
https://www.semanticscholar.org/topic/pyripyropene-A/1250244
NerolidolNerolidol
Other names: 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, [S-(Z)]-; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (Z)-(S)-(+)-; (+)-Nerolidol; D-Nerolidol; Nerolidol, cis-(+)-; Peruviol; 3,7,11-Trimethyl-1,6,10-dodecatriene-3-ol, (Z)-(S)-(+)-; (6Z)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (3S,6Z)-; NSC 60598; (Z)-Nerolidol; cis-Nerolidol; Nerolidol (Z); (Z)-«beta»-Nerolidol; cis-Nerolidol A ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C142507&Units=CAL&Mask=2000&Type=KOVATS-RI-NON-POLAR-ISOTHERMAL
NerolidolNerolidol
Other names: 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, [S-(Z)]-; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (Z)-(S)-(+)-; (+)-Nerolidol; D-Nerolidol; Nerolidol, cis-(+)-; Peruviol; 3,7,11-Trimethyl-1,6,10-dodecatriene-3-ol, (Z)-(S)-(+)-; (6Z)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol; 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (3S,6Z)-; NSC 60598; (Z)-Nerolidol; cis-Nerolidol; Nerolidol (Z); (Z)-«beta»-Nerolidol; cis-Nerolidol A ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C142507&Units=CAL&Mask=2000&Type=KOVATS-RI-NON-POLAR-RAMP
Huperzine A And Its Brain Boosting BenefitsHuperzine A And Its Brain Boosting Benefits
Huperzine effect on memory and brain function. Huperzine A can be used with a number of other nootropics to make some great stacks.
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Huperzine AHuperzine A
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Plus itPlus it
5185 The potent induction of apoptosis in various types of tumor cells, contrasted to largely reversible non-apoptotic effects in normal cells is one of the hallmarks of a novel dual-action DNA- and protein-alkylating drug, irofulven (hydroxymethylacylfulvene). Previous studies suggested the contribution of both nuclear and cytoplasmic signaling to apoptosis by irofulven. To better understand the nature of the differential responses of tumor and normal cells, we used a cell-free apoptosis mimicking system consisting of isolated nuclei and cytosolic extracts. We examined homologous and heterologous mixes of nuclei and cytosols from cancer cells (CEM and LNCaP-Pro5), which initiate apoptosis in response to irofulven, and from normal cells (NCM 460), which display a non-apoptotic cytostatic response. Cytosols were obtained either from untreated or drug-treated cells. In the latter case, irofulven concentrations were adjusted to provide equal levels of intracellular drug-macromolecule adducts in ...
http://cancerres.aacrjournals.org/content/64/7_Supplement/1195.4
The Benefits of the Terpene Beta-Caryophyllene for Pain | LeaflyThe Benefits of the Terpene Beta-Caryophyllene for Pain | Leafly
Beta-caryophyllene, a common cannabis terpene, can help you manage pain. Learn more about these high-caryophyllene strains & where you can find them.
https://www.leafly.ca/news/strains-products/benefits-of-high-caryophyllene-cannabis-strains-for-pain
Huperzine A |Hup A | AChE antagonist | Hello BioHuperzine A |Hup A | AChE antagonist | Hello Bio
Buy (-)-Huperzine A - an affordable, high quality AChE antagonist from Hello Bio, a trusted supplier for life science researchers worldwide
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Huperzine-A | 4-HBtalk: The 4-Hour Body ForumHuperzine-A | 4-HBtalk: The 4-Hour Body Forum
Welcome to 4hbtalk.com - The largest 4 Hour Body forum. This forum is a place where you can ask questions about exercises, the slow carb diet, the PAGG stack or anything related to creating your four hour body. The forum was built around The 4-Hour body book by Tim Ferris. This community is in no way affiliated with the 4 Hour Body or Tim Ferris.
http://4hbtalk.com/viewtopic.php?p=3080
Huperzine-A | 4-HBtalk: The 4-Hour Body ForumHuperzine-A | 4-HBtalk: The 4-Hour Body Forum
Welcome to 4hbtalk.com - The largest 4 Hour Body forum. This forum is a place where you can ask questions about exercises, the slow carb diet, the PAGG stack or anything related to creating your four hour body. The forum was built around The 4-Hour body book by Tim Ferris. This community is in no way affiliated with the 4 Hour Body or Tim Ferris.
http://4hbtalk.com/viewtopic.php?f=8&t=410
Smiths Food and Drug - Source Naturals Huperzine A, 200 mcg - 60 TabletsSmiths Food and Drug - Source Naturals Huperzine A, 200 mcg - 60 Tablets
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TripSit - HUPERZINE-A FactsheetTripSit - HUPERZINE-A Factsheet
Note: This substance is usually taken once a day, and is usually cycled off after 2-4 weeks. The optimal amount of time to break for in unknown as of yet. The doses are the same as for Oral ...
https://tripbot.tripsit.me/factsheet/HUPERZINE-A
Huperzine A 100 mcg 60 Tabs , made by source-naturalsHuperzine A 100 mcg 60 Tabs , made by source-naturals
Product Page for Huperzine A 100 mcg 60 Tabs made by source-naturals offering price, ingredients and full item description from betterlife
https://www.betterlife.com/product/huperzine-a-100-mcg/source-naturals/39321
Huperzine A | Doctors HospitalHuperzine A | Doctors Hospital
Learn more about Huperzine A at Doctors Hospital of Augusta Uses Principal Proposed Uses Alzheimers Disease and Other Forms of Dementia ...
https://doctors-hospital.net/hl/?/2010814945/Huperzine-A&com.dotmarketing.htmlpage.language=1
Sesquiterpenoids - Terpenoids and Steroids (RSC Publishing)Sesquiterpenoids - Terpenoids and Steroids (RSC Publishing)
You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page ...
https://pubs.rsc.org/en/content/chapter/bk9780851862866-00077/978-0-85186-286-6
Phytoalexins | GreenMedInfo | Substance | Natural MedicinePhytoalexins | GreenMedInfo | Substance | Natural Medicine
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
https://www.greenmedinfo.com/substance/phytoalexins
Search Articles | University of Toronto Libraries
Display omitted] New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as ...
https://query.library.utoronto.ca/index.php/search/q?kw=Author:Hitora,%20Y
Zerumbone | GreenMedInfo | Substance | Natural Medicine | AlternativeZerumbone | GreenMedInfo | Substance | Natural Medicine | Alternative
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
https://www.greenmedinfo.com/substance/zerumbone
Study suggests starve cancer of energy with natural molecule -- Science & Technology -- Sott.netStudy suggests starve cancer of energy with natural molecule -- Science & Technology -- Sott.net
Cancers energy source can be thwarted by a naturally-occurring molecule which stops affected cells from consuming sugar, according to a new study. Koningic acid (KA) was found to disrupt the metabolism of cancerous cells. Published in Cell...
https://www.sott.net/article/362074-Study-suggests-starve-cancer-of-energy-with-natural-molecule
Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol...Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol...
article{76337ac6-36e6-4fff-b6e8-dfb8093c0fd5, abstract = {A clone encoding farnesyl diphosphate synthase (FPPS) was obtained by PCR from a cDNA library made from young leaves of Artemisia annua. A cDNA clone encoding the tobacco epi-aristolochene synthase (eAS) was kindly supplied by J. Chappell (University of Kentucky, Lexington, KY, USA). Two fusions were constructed, i.e. FPPS/eAS and eAS/FPPS. The stop codon of the N-terminal enzyme was removed and replaced by a short peptide (Gly-Ser-Gly) to introduce a linker between the two ORFs. These two fusions and the two single cDNA clones were separately introduced into a bacterial expression vector (pET32). Escherichia coli was transformed with the expression vectors and enzymatically active soluble proteins were obtained after induction with isopropyl thio-beta-d-thiogalactoside. The recombinant enzymes were purified using immobilized metal affinity chromatography on Co2+ columns. The fusion enzymes produced epi-aristolochene from isopentenyl ...
https://lup.lub.lu.se/search/publication/109574
Cloning and Bacterial Expression of Sesquiterpene Cyclase, a Key Branch Point Enzyme for the Synthesis of Sesquiterpenoid...
Sesquiterpene cyclase, a branch point enzyme in the general isoprenoid pathway for the synthesis of phytoalexin capsidiol, was induced in detached leaves of Capsicum annuum (pepper) by UV treatment. The inducibility of cyclase enzyme activities paralleled the absolute amount of cyclase protein(s) of pepper immunodetected by monoclonal antibodies raised against tobacco sesquiterpene cyclase. A cDNA library was constructed with poly(A)+ RNA isolated from 24 h UV-challenged leaves of pepper. A cDNA clone for sesquiterpene cyclase in pepper was isolated by using a tobacco 5-epi aristolochene synthase gene as a hetero-logous probe. The predicted protein encoded by this cDNA was comprised of 559 amino acids and had a relative molecular mass of 65,095. The primary structural information from the cDNA clone revealed that it shared 77%, 72% and 49% identity with 5-epi aristolochene, vetispiradiene, and cadinene synthase, respectively. The enzymatic product catalyzed by the cDNA clone in bacteria was ...
http://oxfordindex.oup.com/view/10.1093/oxfordjournals.pcp.a029452
Involvement of Jasmonic Acid in Elicitor-Induced Phytoalexin Production in Suspension-Cultured Rice Cells | Plant PhysiologyInvolvement of Jasmonic Acid in Elicitor-Induced Phytoalexin Production in Suspension-Cultured Rice Cells | Plant Physiology
It has been suggested that jasmonic acid (JA) could be an integral part of a general signal transduction system regulating inducible defense genes in plants. It was reported that treatment with an elicitor (N-acetylchitoheptaose) induced production of phytoalexin in suspension-cultured rice (Oryza sativa L.) cells. In this study, the role of JA in the induction of phytoalexin production by N-acetylchitoheptaose was investigated. Exogenously applied ([plus or minus])-JA (10-4 M) clearly induced the production of momilactone A, a major phytoalexin, in suspension-cultured rice cells. On the other hand, in rice cells treated with N-acetylchitoheptaose, endogenous JA was rapidly and transiently accumulated prior to accumulation of momilactone A. Treatment with ibuprofen, an inhibitor of JA biosynthesis, reduced production of momilactone A in the cells treated with N-acetylchitoheptaose, but the addition of ([plus or minus])-JA increased production of momilactone A to levels higher than those in the ...
http://www.plantphysiol.org/content/110/2/387?ijkey=e3b9fdf5f880fc7c7ff2489137954a2deb8b2b00&keytype2=tf_ipsecsha
WRKY45-dependent priming of diterpenoid phytoalexin biosynthesis in rice and the role of cytokinin in triggering the reaction,...WRKY45-dependent priming of diterpenoid phytoalexin biosynthesis in rice and the role of cytokinin in triggering the reaction,...
Read WRKY45-dependent priming of diterpenoid phytoalexin biosynthesis in rice and the role of cytokinin in triggering the reaction, Plant Molecular Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/wrky45-dependent-priming-of-diterpenoid-phytoalexin-biosynthesis-in-B2HQxNZkkc
KAKEN - Research Projects | INHIBITORY EFFECT OF ANGIOGENESIS INHIBITOR TNP-470 ON MALIGNANT TUMOR (KAKENHI-PROJECT-06671634)KAKEN - Research Projects | INHIBITORY EFFECT OF ANGIOGENESIS INHIBITOR TNP-470 ON MALIGNANT TUMOR (KAKENHI-PROJECT-06671634)
Principal Investigator：KODAMA Shoji, Project Period (FY)：1994 - 1995, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：Obstetrics and gynecology
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671634/
Temporal and spatial expression of terpene synthase genes associated with agarwood formation in Aquilaria malaccensis Lam | New...Temporal and spatial expression of terpene synthase genes associated with agarwood formation in Aquilaria malaccensis Lam | New...
The diseased wood, agarwood, from the tropical tree taxa Aquilaria, is famed for its unique fragrance and medicinal values, mainly due to its richness in secondary metabolites such as the sesquiterpenes. The presence of sesquiterpenes in high numbers and amounts correlates with agarwood of high quality. To understand the synthesis of this important compound, we cloned two candidate genes in the terpenoid synthesis pathway from Aquilaria malaccensis Lam., a major agarwood tree species. The genes encoding sesquiterpene synthase (AmSesTPS1) and δ-guaiene synthase (AmGuaiS1) were successfully cloned from callus RNA, using specific primers derived from transcriptomic data, in a reverse transcription PCR reaction. The full-length complementary DNA (cDNA) sequence of AmSesTPS1 was 1632 bp encoding for 544 amino acids, and AmGuaiS1 was 1644 bp encoding for 547 amino acids. Sequence alignment analysis showed that AmSesTPS1 shared between 99 to 100 % identity with sesquiterpene synthase from Aquilaria sinensis
https://nzjforestryscience.springeropen.com/articles/10.1186/s40490-016-0068-9
Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications | GeneticsGenomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications | Genetics
The current evolutionary hypothesis and the previous phylogenetic tree (Bohlmannet al. 1998b) both affirm that plant terpene synthases involved in secondary metabolism have a common ancestral origin from a terpene synthase involved in primary metabolism. However, these models differ in the placement of the class III terpene synthases (Figures 6, A and B, and 7). The inferred phylogenetic tree in Figure 6A suggests that the class III types (angiosperm terpene synthases) involved in secondary metabolism are descendants (evolving by divergent evolution) of the class II types (gymnosperm monoterpene and/or sesquiterpene synthases) involved in secondary metabolism, whereas Figure 6B indicates that class III types are not direct descendants of class II types, yet share a common ancestor. The latter (including the gene architecture information as valid) infers that gymnosperm and angiosperm terpene synthases involved in secondary metabolism diverged prior to the three loss events illustrated in Figure ...
http://www.genetics.org/content/158/2/811
Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi - 香港中文大學學術研究文庫 - Converis标准配置Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi - 香港中文大學學術研究文庫 - Converis标准配置
摘要Ten new sesquiterpene lactones, carlipsines A J (1-10), and 12 known analogues (11-22) were isolated from the whole plant of Carpesium lipskyi. Their structures were elucidated by using 1D and 2D NMR and HRESIMS analyses, and their absolute configurations were confirmed by X-ray diffraction studies. All compounds were identified as germacranolides with diverse substructural features. Compounds 1-4 are 2,5-hemiacetal-linked germacranolides. Compounds 5 and 6 possess a 1,2-epoxy moiety. Compounds 7 and 8 represent unusual 1,5-hemiacetal-linked germacranolides. Compounds 9 and 10 contain a tetrahydrofuran unit with the oxygen atom bridging C-1 and C-8. Compounds 6, 7, 8, 19, 20, 21, and 22 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.8 to 10.3 mu M. ...
https://aims.cuhk.edu.hk/converis/portal/detail/Publication/97138623?auxfun=&lang=zh_HK
Huperzine-AHuperzine-A
Huperzine-A Review Introduction Huperzine-A is a unique chemical purified from the Chinese plant Huperzia Serrata or chinese moss. Its main functionality is as
http://www.smartnootropics.com/huperzine-a/
A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis<...
TY - JOUR. T1 - A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis. AU - Kim, Youn C.. AU - Bolzani, Vanderlan Da S.. AU - Baj, Nina. AU - Gunatilaka, A. A.Leslie. AU - Kingston, David G.I.. PY - 1996/2/15. Y1 - 1996/2/15. N2 - Bioassay-guided fractionation of an MeCOEt extract of Frullania nisquallensis Sull. has furnished a DNA-damaging sesquiterpene, costunolide (1), and two inactive compounds, a sesquiterpene (-)-frullanolide (2) and a tridepside tenuiorin (3). 13C-NMR data of 3 are reported.. AB - Bioassay-guided fractionation of an MeCOEt extract of Frullania nisquallensis Sull. has furnished a DNA-damaging sesquiterpene, costunolide (1), and two inactive compounds, a sesquiterpene (-)-frullanolide (2) and a tridepside tenuiorin (3). 13C-NMR data of 3 are reported.. UR - http://www.scopus.com/inward/record.url?scp=0030065818&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030065818&partnerID=8YFLogxK. U2 - 10.1055/s-2006-957800. DO - ...
https://arizona.pure.elsevier.com/en/publications/a-dna-damaging-sesquiterpene-and-other-constituents-from-frullani
Molecules | Free Full-Text | Self-Organizing Maps of Molecular Descriptors for Sesquiterpene Lactones and Their Application to...Molecules | Free Full-Text | Self-Organizing Maps of Molecular Descriptors for Sesquiterpene Lactones and Their Application to...
The Asteraceae, one of the largest families among angiosperms, is chemically characterised by the production of sesquiterpene lactones (SLs). A total of 1,111 SLs, which were extracted from 658 species, 161 genera, 63 subtribes and 15 tribes of Asteraceae, were represented and registered in two dimensions in the SISTEMATX, an in-house software system, and were associated with their botanical sources. The respective 11 block of descriptors: Constitutional, Functional groups, BCUT, Atom-centred, 2D autocorrelations, Topological, Geometrical, RDF, 3D-MoRSE, GETAWAY and WHIM were used as input data to separate the botanical occurrences through self-organising maps. Maps that were generated with each descriptor divided the Asteraceae tribes, with total index values between 66.7% and 83.6%. The analysis of the results shows evident similarities among the Heliantheae, Helenieae and Eupatorieae tribes as well as between the Anthemideae and Inuleae tribes. Those observations are in agreement with systematic
http://www.mdpi.com/1420-3049/17/4/4684
Evaluation of herbicide potential of sesquiterpene lactone and flavonoid: impact on germination, seedling growth indices and...Evaluation of herbicide potential of sesquiterpene lactone and flavonoid: impact on germination, seedling growth indices and...
Evaluation of herbicide potential of sesquiterpene lactone and flavonoid: impact on germination, seedling growth indices and root length in arabidopsis ...
https://www.biosaline.org/publications/evaluation-herbicide-potential-sesquiterpene-lactone-and-flavonoid-impact-germination
Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives | Antimicrobial Agents and ChemotherapyDiscovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives | Antimicrobial Agents and Chemotherapy
Compound potency: IC50 and MLC determination.Cell viability assays are affected not just by the kinetics of the targeted protein (most likely MetAP2 in this case) but also by additional factors, such as compound permeation across the trophozoite membrane and the susceptibility of the compound to degrading cellular enzymes. These factors also affect compound efficacy in vivo. Additionally, both in vitro and in vivo cell viability may be affected by unknown off-target inhibition. Although the only validated target of fumagillol derivatives is MetAP2, the MetAP2-independent effects of fumagillin on angiogenesis are known (34, 35). As angiogenesis does not exist in G. lamblia, currently, there is no alternative MapAP2-independent activity of fumagillin that could be tested. Nevertheless, the possibility of a contribution of off-target inhibition to the lethal effects of drug candidates cannot be excluded.. Antigiardia assays followed by enzyme inhibition determination facilitated the selection of ...
https://aac.asm.org/content/64/10/e00582-20
Efficacy of parthenolide on lung histopathology in a murine model of asthma | Allergologia et ImmunopathologiaEfficacy of parthenolide on lung histopathology in a murine model of asthma | Allergologia et Immunopathologia
Preparations of lung homogenates. Animals were sacrificed by an overdose of ketamin 24h after the last drug administration. Lungs were removed and washed with cold PBS three times in order to remove blood. Lung tissues were taken into 2ml microcentrifuge tubes and stored at −80°C until analysis. On the study day, frozen lungs were thawed, weighed (60-80mg), transferred into different tubes on ice containing 5ml of stainless beads, 0.1% SDS, protease inhibitor cocktail (Sigma-Aldrich, St. Louis, MO, USA) and 0.1mg/ml phenylmethanesulfonyl fluoride (PMSF) in PBS. Microcentrifuge tubes were transferred to precooled Tissuelyser LT racks and placed into TissueLyser (Qiagen, Germany) homogenisator. Frequency and time were set to 50 and 5min, respectively. The homogenates were then centrifugated at 15,000×g for 1h at 4°C. The supernatants were stored at −80°C.. Measurement of cytokines. Levels of IL-4 and IL-5 were quantified in the supernatants of the lung tissue by standard ELISA protocols ...
https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-efficacy-parthenolide-on-lung-histopathology-S0301054616301057
IJMS | Free Full-Text | Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella...IJMS | Free Full-Text | Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella...
Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
http://www.mdpi.com/1422-0067/15/9/15679
Publication : USDA ARSPublication : USDA ARS
Citation: N/A Interpretive Summary: Technical Abstract: Phytoalexins are inducible biochemicals that locally protect plant tissues against biotic attack. Due to their agronomic significance, maize and rice have been extensively investigated for their terpenoid-based defenses which include insect-inducible monoterpene and sesquiterpene volatiles. Rice also produces a complex array of non-volatile pathogen-inducible terpenoid phytoalexins; however, until recently analogous pathways in maize were unknown. We recently discovered the existence of a complex series of sesquiterpene and diterpene phytoalexins in maize stalks following attack by the European corn borer (Ostrinia nubilalis) and pathogenic fungi. The predominant acidic sesquiterpene and diterpene phytoalexins, termed zealexins and kauralexins, are likely derived from ß-macrocarpene and ent-kaur-15-ene, respectively. Following induction, the predicted volatile terpenoid precursors exist at relatively low levels compared to the oxygenated ...
https://www.ars.usda.gov/research/publications/publication/?seqNo115=277037&pf=1
Cooling Inflammation: Phytochemicals, Natural Antibiotics and AntioxidantsCooling Inflammation: Phytochemicals, Natural Antibiotics and Antioxidants
The liver is the only organ that can be continually regenerated and that is because humans have evolved to eat plants, and phytoalexins take their toll on the liver. As plants are digested and absorbed in the small intestines and transported to the liver, phytoalexins accompany the nutrients. Most of the phytochemicals are chemically detoxified by liver enzymes, but the phytoalexins kill some liver cells with each meal and some of the phytoalexins circulate in the blood and reach other tissues. The phytoalexins are evolutionarily adapted to bind to proteins to disrupt essential enzymes of microorganisms and herbivores, and like pharmaceuticals to which they are chemically and functionally related, they have numerous side effects. The chemical reactivity is what is detected as the antioxidant property of phytoalexins. Antioxidant is nutritionally meaningless and basically reflects the chemical toxicity of phytochemicals. After all, you cant easily sell chemicals that are inherently toxic. Meat ...
http://coolinginflammation.blogspot.com/2014/02/phytochemicals-natural-antibiotics-and.html?showComment=1391414056768
Deficiency in phytoalexin production causes enhanced susceptibility of Arabidopsis thaliana to the fungus Alternaria...Deficiency in phytoalexin production causes enhanced susceptibility of Arabidopsis thaliana to the fungus Alternaria...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/10476063?dopt=Abstract
Huperzine A Review, Uses and Mechanisms of ActionHuperzine A Review, Uses and Mechanisms of Action
Huperzine A is an Acetylcholinesterase Inhibitor that boosts Memory & treats Alzheimers. Read reviews on dosages, benefits and effects of Huperzine A.
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delta-selinene synthase Summary Report | CureHunterdelta-selinene synthase Summary Report | CureHunter
delta-selinene synthase: a sesquiterpene synthase from Grand fir, Abies grandis; forms a total of 34 different sesquiterpenes, chiefly delta-selinene; MW 68 kDa; amino acid sequence in first source; GenBank U92267
http://www.curehunter.com/public/keywordSummaryC110538-delta-selinene-synthase.do
Further Cytotoxic Sesquiterpene Lactones from <i>Elephantopus mollis</i> K...
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
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Sesquiterpene lactones from Anthemis wiedemanniana | AVESİSSesquiterpene lactones from Anthemis wiedemanniana | AVESİS
Copy For Citation Çelik S. , Rosselli S., Maggio A., Raccuglia R., Uysal İ., Kisiel W., ...More BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol.33, no.9, pp.952-956, 2005 (Journal Indexed in SCI) ...
https://avesis.yildiz.edu.tr/publication/details/e8bfe979-0f67-4c42-bcac-2059e7da708a/sesquiterpene-lactones-from-anthemis-wiedemanniana
farnesol - oi
the trivial name for any of four possible stereoisomers of 3,7,11‐trimethyl‐2,6,10‐dodecatrien‐1‐ol; a sesquiterpene alcohol. The 2E,6E‐isomer is found in many essential oils. The 2Z,6E‐isomer is a minor constituent of some essential oils.. [...] ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095810979
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Brain Protex w/Huperzine A (60 Caps)Brain Protex w/Huperzine A (60 Caps)
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Huperzine A Science: Read What The Researchers Have FoundHuperzine A Science: Read What The Researchers Have Found
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Know Your Terpenes! - HarborsideKnow Your Terpenes! - Harborside
In the world of cannabis science, few things are more exciting than our developing knowledge of the world of terpenes.. Terpenes can be found in the essential oils of all plants. In cannabis, they play a major role in how our bodies interact with particular strains. Terpenes give us a better understanding of how strains may interact with us individually and can allow us to better curate the experience were looking for. Most famously, terpenes are responsible for the way cannabis hits your nose. Those lemon, grape and fuel smells that denote world-class cannabis for many connoisseurs are actually variations in the concentration of particular terpenes from strain to strain!. Researchers have identified more than 140 terpenoids in cannabis that include terpenes and their variations, called diterpenes and sesquiterpenes. Of those 140 terpenoids, 17 have been found to be the most common in most cannabis strains.. Currently, were expanding our knowledge around the synergistic effects of cannabinoids ...
https://www.shopharborside.com/blog/know-your-terps/?utm_source=rss&utm_medium=rss&utm_campaign=know-your-terps
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Natural Gardening: A trio of greensNatural Gardening: A trio of greens
Ive been growing something called Italian dandelion for some time. Actually, since it seems to be perennial, and has really deep roots, I cant actually dig it all out. Its quite attractive and tasty, if prepared by leaching out most of the bitter sesquiterpene lactones first! It does appear to be a selection of common dandelion, Taraxacum officinale; my plants came from seed ordered from The Cooks Garden. ...
https://naturalgardening.blogspot.com/2008/07/trio-of-greens.html
IV Artesunate - Cancer TutorIV Artesunate - Cancer Tutor
Data for artesunate, used for the treatment of malaria, indicates IVC in conjunction with IV Artesunate makes a substantial difference in advanced cancers.
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How to Take Artesunate and Dose of Artesunate| MedindiaHow to Take Artesunate and Dose of Artesunate| Medindia
Find out how to take Artesunate (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.
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C. Blöch (WU) project "Phylogeny of the genus Leontopodium" S. Safer: Blattmaterial entnommen für Projekt Leontopodium,
https://www.europeana.eu/portal/en/record/11602/HERBARWU_WU_AUSTRIA_59799.html
Huperzine A improved cognition - Nutrition Express ArticlesHuperzine A improved cognition - Nutrition Express Articles
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Product results may vary from person to person. † Compare price is the price compared to the manufacturers suggested retail price or estimated selling price of the same or similar item at full-price stores. See Pricing Policy for details.. Information provided on this site is solely for informational purposes only. It is not a substitute for professional medical advice. Read more ©2000-2018 Nutrition Express Corporation. All rights reserved ...
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Impact Whey vs. Impact Whey Isolate Proteina din zer contine proteina, grasimi, carbohidrati, vitamine si minerale. Datorita continutului puternic de amino acizi si abilitatea de ...
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SesquiterpeneSesquiterpene
Look up sesquiterpene in Wiktionary, the free dictionary. Sesquiterpenes at the US National Library of Medicine Medical Subject ... which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than ... Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like ... Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. They are found in ...
https://en.wikipedia.org/wiki/Sesquiterpene
Sesquiterpene lactoneSesquiterpene lactone
... s (SLs) are a class of sesquiterpenoids that contain a lactone ring. They are most often found in plants ... Media related to Sesquiterpene lactones at Wikimedia Commons (CS1 maint: uses authors parameter, Articles with short ... Dall'Acqua S, Viola G, Giorgetti M, Loi MC, Innocenti G (August 2006). "Two new sesquiterpene lactones from the leaves of ... Sesquiterpene lactones can be divided into several main classes including germacranolides, heliangolides, guaianolides, ...
https://en.wikipedia.org/wiki/Sesquiterpene_lactone
Sesquiterpene cyclaseSesquiterpene cyclase
... may refer to: Delta-cadinene synthase, an enzyme Aristolochene synthase, an enzyme Trichodiene synthase, ... an enzyme This disambiguation page lists articles associated with the title Sesquiterpene cyclase. If an internal link led you ...
https://en.wikipedia.org/wiki/Sesquiterpene_cyclase
TurmeroneTurmerone
Tumerones are a group of related chemical compounds of the sesquiterpene class. They are found in turmeric (Curcuma longa), ...
https://en.wikipedia.org/wiki/Turmerone
ZingibereneZingiberene
Sesquiterpenes of ginger oil". Collection of Czechoslovak Chemical Communications. 18: 297-300. K. Rani (1999). "Cyclisation of ... Zingiberene is a monocyclic sesquiterpene that is the predominant constituent of the oil of ginger (Zingiber officinale), from ... and sesquiterpenes. Gingerol sequiphellandrene Herout, Vlastimil; Benesova, Vera; Pliva, Josef (1953). "Terpenes. XLI. ...
https://en.wikipedia.org/wiki/Zingiberene
CatuabaCatuaba
Garcez, W. S.; Garcez, F. R.; Ramos, L.; Camargo, M. J.; Damasceno Jr., G. A. (1997). "Sesquiterpenes from Trichilia catigua". ...
https://en.wikipedia.org/wiki/Catuaba
Cupressus macrocarpaCupressus macrocarpa
Laurence G. Cool (2005). "Sesquiterpenes from Cupressus macrocarpa foliage". Phytochemistry. 66 (2): 249-260. doi:10.1016/j. ... Unusual sesquiterpenes can be found in the foliage. Longiborneol (also known as juniperol or macrocarpol) can also be isolated ...
https://en.wikipedia.org/wiki/Cupressus_macrocarpa
Russula sardoniaRussula sardonia
The active agent has not been identified but thought to be sesquiterpenes, which have been isolated from this species and the ... 1980). Sesquiterpenes from Russula sardonia. Phytochemistry 19: 93-97 Benjamin, Denis R. (1995). Mushrooms: poisons and ...
https://en.wikipedia.org/wiki/Russula_sardonia
MonoterpeneMonoterpene
Terpene Terpenoid Diterpene Sesquiterpene Eberhard Breitmaier (2006). "Hemi‐ and Monoterpenes". Terpenes: Flavors, Fragrances, ... Davis, Edward M.; Croteau, Rodney (2000). "Cyclization enzymes in the biosynthesis of monoterpenes, sesquiterpenes, and ... and sesquiterpenes (e.g., zederone, germacrone) exhibited liver toxicity" and that i.a. intensive research on terpenes toxicity ... "Hepatotoxicity of monoterpenes and sesquiterpenes". Archives of Toxicology. 92 (1): 1-13. doi:10.1007/s00204-017-2062-2. ISSN ...
https://en.wikipedia.org/wiki/Monoterpene
Organ pipe coralOrgan pipe coral
Duh, Chang-Yih; Chen, Kuan-Jen; El-Gamal, Ali Ali H.; Dai, Chang-Feng (November 2001). "Sesquiterpenes from the Formosan ...
https://en.wikipedia.org/wiki/Organ_pipe_coral
Lactarius sanguifluusLactarius sanguifluus
The latex contains sesquiterpene pigments with guaiane skeletons; these include the compounds given the common names ... 9 (4): 247-8. doi:10.1016/0305-1978(81)90002-8. De Rosa S, De Stefano S (1986). "Guaiane sesquiterpenes from Lactarius ... "The isolation of a guaiane sesquiterpene from fruit bodies of Lactarius sanguifluus". Phytochemistry. 28 (9): 2501-2. doi: ...
https://en.wikipedia.org/wiki/Lactarius_sanguifluus
Cāng zhúCāng zhú
additional sesquiterpenes Joseph P. Hou; Youyu Jin (2005-04-25). The healing power of Chinese herbs and medicinal recipes. ... Wang, H. X.; Liu, C. M.; Liu, Q.; Gao, K. (2008). "Three types of sesquiterpenes from rhizomes of Atractylodes lancea". ...
https://en.wikipedia.org/wiki/Cāng_zhú
Curcuma comosaCurcuma comosa
2009). Sesquiterpenes from Curcuma comosa. Journal of Natural Medicines 63 102. Association of the School of Thai Traditional ...
https://en.wikipedia.org/wiki/Curcuma_comosa
Artemisia annuaArtemisia annua
Artemisinin is a sesquiterpene lactone with an endoperoxide bridge and has been produced as an antimalarial drug. The efficacy ... Other phytochemicals include 38 sesquiterpenes. Dihydroartemisinin is the active metabolite of artemisinin, and artesunate is a ...
https://en.wikipedia.org/wiki/Artemisia_annua
NardosinoneNardosinone
... is a sesquiterpene and chemical constituent of Nardostachys jatamansi. In in vitro studies, the compound has ... Itokawa H, Masuyama K, Morita H, Takeya K (1993). "Cytotoxic sesquiterpenes from Nardostachys chinensis". Chemical & ... Sesquiterpenes, Organic peroxides, Enones, Oxygen heterocycles, Heterocyclic compounds with 3 rings). ...
https://en.wikipedia.org/wiki/Nardosinone
Russula sanguinariaRussula sanguinaria
The active agent has not been identified but is thought to consist of sesquiterpenes, which have been isolated from Russula ... 1980). "Sesquiterpenes from Russula sardonia." Phytochemistry 19: 93-97 Benjamin, Denis R. (1995). Mushrooms: Poisons and ...
https://en.wikipedia.org/wiki/Russula_sanguinaria
CarotolCarotol
This sesquiterpene alcohol is thought to be formed in carrot seeds (Daucus carota L., Umbelliferae) during the vegetation ... Parker, W.; Roberts, J.S. (1967). "Sesquiterpene Biogenesis". Quart. Rev. 21 (3): 331-363. doi:10.1039/qr9672100331. (Articles ... This type of cyclisation is unconventional for the typical chemistry of sesquiterpenes. The only other proposed mechanism ...
https://en.wikipedia.org/wiki/Carotol
Vinylcyclopropane rearrangementVinylcyclopropane rearrangement
"Stereocontrolled Total Synthesis of Isocomene Sesquiterpenes". Tetrahedron Lett. 25 (23): 2447. doi:10.1016/S0040-4039(01)81201 ...
https://en.wikipedia.org/wiki/Vinylcyclopropane_rearrangement
CopaeneCopaene
Chemically, the copaenes are tricyclic sesquiterpenes. The molecules are chiral, and the α-copaene enantiomer most commonly ... Minor Sesquiterpenes of the Wood of Pinus silvestris L. And of Swedish Sulphate Turpentine". Acta Chemica Scandinavica. 21: 152 ...
https://en.wikipedia.org/wiki/Copaene
Trifluoroperacetic acidTrifluoroperacetic acid
Neosporol, Sporol". Part B: Bicyclic and Tricyclic Sesquiterpenes. The Total Synthesis of Natural Products. Vol. 11. John Wiley ...
https://en.wikipedia.org/wiki/Trifluoroperacetic_acid
DioxolaneDioxolane
Neosporol, Sporol". Part B: Bicyclic and Tricyclic Sesquiterpenes. The Total Synthesis of Natural Products. Vol. 11. John Wiley ...
https://en.wikipedia.org/wiki/Dioxolane
Ring expansion and contractionRing expansion and contraction
Büchi, G.; Hofheinz, W.; Paukstelis, J. V. (November 1969). "Synthesis of (-)-aromadendrene and related sesquiterpenes". ...
https://en.wikipedia.org/wiki/Ring_expansion_and_contraction
CadinenesCadinenes
The term cadinene has sometimes also been used in a broad sense to refer to any sesquiterpene with the so-called cadalane (4- ...
https://en.wikipedia.org/wiki/Cadinenes
Oplopanax japonicusOplopanax japonicus
A sesquiterpene[which?] has been isolated and a synthetic derivative of the ketone form has been commercially produced in Japan ... An example of a sesquiterpene that has been isolated and characterized is oplapanone. "Oplopanax japonicus - (Nakai.)Nakai". ... a new sesquiterpene from oplopanax japonicus (NAKAI) NAKAI". Tetrahedron. 22: 219-225. doi:10.1016/s0040-4020(01)99108-2. Media ...
https://en.wikipedia.org/wiki/Oplopanax_japonicus
TerpeneTerpene
Sesquiterpenes consist of three isoprene units and have the molecular formula C15H24. Examples of sesquiterpenes and ... Similarly all sesquiterpenes and diterpenes have formulas of C15H24 and C20H32 respectively. The structural diversity of mono ... Humulene, a sesquiterpene. Taxadiene, a diterpene, precursor to the diterpenoid taxol, an anticancer agent. Squalene, a ... For example, the aroma and flavor of hops comes, in part, from sesquiterpenes (mainly α-humulene and β-caryophyllene), which ...
https://en.wikipedia.org/wiki/Terpene
Cannabis sativaCannabis sativa
These are mainly volatile terpenes and sesquiterpenes. α-Pinene Myrcene Linalool Limonene Trans-β-ocimene α-Terpinolene Trans- ... These compounds are found in much lower concentrations than the major terpenes and sesquiterpenes. However, they contribute ...
https://en.wikipedia.org/wiki/Cannabis_sativa
TerpenoidTerpenoid
Davis, Edward M.; Croteau, Rodney (2000). "Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and ... Ashour, Mohamed; Wink, Michael; Gershenzon, Jonathan (2010). "Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes and ...
https://en.wikipedia.org/wiki/Terpenoid
Neonothopanus nambiNeonothopanus nambi
"Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi". Tetrahedron. 68 (39): 8261-8266. doi:10.1016/j.tet. ...
https://en.wikipedia.org/wiki/Neonothopanus_nambi
JuvabioneJuvabione
They occur naturally as part of a mixture of sesquiterpenes based upon the bisabolane scaffold. Sesquiterpenes of this family ... The first sesquiterpene to be formed, (E)-α-bisabolene (formed by (E)-α-bisabolene synthase), can be further transformed into ... Sesquiterpenes are a class of terpenoids based upon a 15-carbon unit scaffold synthesized from isoprene units via the ... The transcription of sesquiterpene synthases was shown to begin on the third day following insect attack. Sesquiterpenoid JHAs ...
https://en.wikipedia.org/wiki/Juvabione
Neolitsea parvigemmaNeolitsea parvigemma
Chen, K. S.; Hsieh, P. W.; Hwang, T. L.; Chang, F. R.; Wu, Y. C. (2005). "Anti-inflammatory furanogermacrane sesquiterpenes ... The hydrodistillated leaf essential oil of N. parvigemma has antifungal and anti-wood-decay fungal properties Sesquiterpenes ...
https://en.wikipedia.org/wiki/Neolitsea_parvigemma
Browsing by Subject SesquiterpenesBrowsing by Subject "Sesquiterpenes"
Global Partnership to Roll Back Malaria; UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (‎World Health OrganizationWorld Health Organization, 2003)‎ ...
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sesquiterpenes Archives - Natures Giftsesquiterpenes Archives - Nature's Gift
Curcuma xanthorrhiza, produced from dried roots, organically grown in Indonesia, and produced in Germany. (Sometimes called "Temulawak"). - anti-oxidant, anti-inflammatory. - oral care. - pain relief, joint pain, arthritis. ...
https://naturesgift.com/product-tag/sesquiterpenes/
Sesquiterpene Biosensors and Uses Thereof - Patent US-2019024193-A1 - PubChemSesquiterpene Biosensors and Uses Thereof - Patent US-2019024193-A1 - PubChem
US-2019024193-A1 chemical patent summary.
https://pubchem.ncbi.nlm.nih.gov/patent/US-2019024193-A1
Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis<...Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis<...
Production of Plant Sesquiterpenes in Saccharomyces cerevisiae : Effect of ERG9 Repression on Sesquiterpene Biosynthesis. In: ... Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis. ... Production of Plant Sesquiterpenes in Saccharomyces cerevisiae : Effect of ERG9 Repression on Sesquiterpene Biosynthesis. / ... Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis. ...
https://orbit.dtu.dk/en/publications/production-of-plant-sesquiterpenes-in-saccharomyces-cerevisiae-ef
Metabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene ProductionMetabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene Production
Sesquiterpenes are a class of natural products with a diverse range of attractive industrial proprieties. Due to economic ... Sesquiterpenes are a class of natural products with a diverse range of attractive industrial proprieties. Due to economic ... It was possible to divert the carbon flux toward the sesquiterpene compound, and the resulting strain shows a 88-fold ... The hydrocarbon α-santalene is a precursor of sesquiterpenes with relevant commercial application and was selected as case ...
https://research.chalmers.se/publication/?id=160270
Artemisia annua L.: evidence of sesquiterpene lactones fraction antinociceptive activity | BMC Complementary Medicine and...Artemisia annua L.: evidence of sesquiterpene lactones' fraction antinociceptive activity | BMC Complementary Medicine and...
The enriched sesquiterpene lactone fraction (Lac-FR) was administrated by intraperitoneal injection producing a relevant ... This study evaluated the pharmacological potential of the enriched sesquiterpene lactone fraction (Lac-FR) on different ... The alcoholic crude extract after artemisinin precipitation maintained an enriched sesquiterpene lactones content with residue ...
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-14-266/figures/4
Beta Cedrene Profile | Sesquiterpenes| Eybna TechnologiesBeta Cedrene Profile | Sesquiterpenes| Eybna Technologies
... a sesquiterpene derived from the essential oils of cedar. Like α-Cedrene. ... Sesquiterpenes Beta Cedrene - Terpene Profile. Along with α-Cedrene, β-Cedrene is one of two isomers that form Cedrene, a ... sesquiterpene derived from the essential oils of cedar. Like α-Cedrene, β-Cedrenes crisp scents of pine and wood have ...
https://eybna.com/terpene/beta-cedrene-terpene-profile/
Renewable production of high density jet fuel precursor sesquiterpenes from Escherichia coli.Renewable production of high density jet fuel precursor sesquiterpenes from Escherichia coli.
In particular, sesquiterpene compounds (C15), such as farnesene and bisabolene, have been identified as promising jet fuel ... We performed a computational analysis to calculate the energy of combustion of these sesquiterpenes and found that their ... candidates.ResultsIn this study, we explored three sesquiterpenes-epi-isozizaene, pentalenene and α-isocomene-as novel jet fuel ... production and managed to achieve comparable amounts of each compound.ConclusionWe produced tricyclic sesquiterpenes epi- ...
https://escholarship.org/uc/item/03s093vn
SESQUITERPENE: Beta- Caryophyllene (BCP) - Promise Life BlogSESQUITERPENE: Beta- Caryophyllene (BCP) - Promise Life Blog
SESQUITERPENE: Beta- Caryophyllene (BCP), SESQUITERPENES, Simple Living, SKIN/ BEAUTY, SPIRITUALITY, URINARY (RENAL) SYSTEM ... SESQUITERPENE: Beta- Caryophyllene (BCP), SESQUITERPENES, SKIN/ BEAUTY, SLEEP, SPIRITUALITY, URINARY (RENAL) SYSTEM ... SESQUITERPENE: Beta- Caryophyllene (BCP), SESQUITERPENES, SKIN/ BEAUTY, SPIRITUALITY, URINARY (RENAL) SYSTEM ... Category: SESQUITERPENE: Beta- Caryophyllene (BCP). Patchouli. ALCOHOLS, BEAUTY/ ANTI- AGING, BRAIN/ MIND, DETOX, DIGESTION, ...
https://promiselifeblog.com/category/constituent-chemistry-of-essential-oils/beta-caryophyllene-bcp/
Aromadendrene</span>Aromadendrene</span>
SESQUITERPENE. *(+)-Aromadendrene. (+)-Aromadendrene analytical standard provided with w/w absolute assay, to be used for ...
https://www.extrasynthese.com/sesquiterpene/71--aromadendrene.html
Cis-Nerolidol Profile | Sesquiterpenes | Eybna TechnologiesCis-Nerolidol Profile | Sesquiterpenes | Eybna Technologies
Sesquiterpenes Cis-Nerolidol- Terpene Profile. Cis-Nerolidol, one of two Nerolidol isomers, is found in many essential oils, ...
https://staging.eybna.com/terpene/cis-nerolidol-terpene-profile/
Nine new sesquiterpenes from Curcuma wenyujin rhizomes. | Fitoterapia;158: 105167, 2022 Apr. | MEDLINENine new sesquiterpenes from Curcuma wenyujin rhizomes. | Fitoterapia;158: 105167, 2022 Apr. | MEDLINE
Nine new sesquiterpenes from Curcuma wenyujin rhizomes. Li, Yahui; Wang, Hui; Wang, Hong; Wu, Yingchun; Li, Yiming; Guo, ... Nine new sesquiterpenes wenyujinones A-I (1-9), along with ten known ones (10-19), were isolated from the rhizomes of Curcuma ... Nine new sesquiterpenes from Curcuma wenyujin rhizomes. ...
https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-35227788
Frontiers | A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of...Frontiers | A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of...
178 compounds including diterpenoids, triterpenes, sesquiterpenes, flavonoids, saponins, phenylpropanoids, lignans, coumarins, ... 178 compounds including diterpenoids, triterpenes, sesquiterpenes, flavonoids, saponins, phenylpropanoids, lignans, coumarins, ... In our study, 70 terpenes, including 56 diterpenoids, 12 triterpene, and two sesquiterpenes, were detected and identified in ... Identification of Diterpenoids, Triterpene, and Sesquiterpenes. Diterpenoids are the major bioactive constituents of XCC. About ...
https://www.frontiersin.org/articles/10.3389/fphar.2020.558471/full
Antibacterial Drimane Sesquiterpenes from Aspergillus ustus. - Fungal Diagnostic Testing | OLM DiagnosticsAntibacterial Drimane Sesquiterpenes from Aspergillus ustus. - Fungal Diagnostic Testing | OLM Diagnostics
The sesquiterpenes exhibited weak activity against the clinically relevant pathogens vancomycin-resistant Enterococcus faecium ... Bioactivity-guided isolation of Aspergillus ustus led to the discovery of five new drimane sesquiterpenes, named ustusal A, ...
http://olmdiagnostics.com/2020/12/22/antibacterial-drimane-sesquiterpenes-from-aspergillus-ustus/
Browsing by SubjectBrowsing by Subject
Sesquiterpenes [‎13]‎. Setaria Nematode [‎1]‎. Severe Acute Malnutrition [‎28]‎. Severe Acute Respiratory Syndrome [‎105]‎. ...
https://apps.who.int/iris/browse?rpp=20&offset=5320&etal=-1&sort_by=-1&type=mesh&starts_with_previous=S&order=ASC
Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities - Geert De VuystNerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities - Geert De Vuyst
Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Article English Educated ... Home › Literature › Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities * Home ... Cite as: De Vuyst, Geert (12 August 2022) Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological ... TitleNerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological ActivitiesAuthor(s)Chan, Weng-Keong, ...
https://geertdevuyst.be/en/publication/2016-chan-nerolidol-a-sesquiterpene-alcohol-with-multi-faceted-pharmacological-and-biological-activities/
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)
... B Zhao, X Lin, L Lei, L Lei, DC ... The SCO5222 protein is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate to the novel tricyclic ... The SCO5222 protein is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate to t... ... sequential allylic oxidations to convert epi-isozizaene to an epimeric mixture of albaflavenols and thence to the sesquiterpene ...
https://cronfa.swan.ac.uk/Record/cronfa10337
Flavones and sesquiterpene lactones from Achillea atrata subsp multifida: Antimicrobial activityFlavones and sesquiterpene lactones from Achillea atrata subsp multifida: Antimicrobial activity
... Authorized Users Only. ... Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts ... Aljančić I, Vajs V, Menković N, Karadžić IM, Juranić N, Milosavljevic S, Macura S. Flavones and sesquiterpene lactones from ... PB - Amer Chemical Soc, Washington T2 - Journal of Natural Products T1 - Flavones and sesquiterpene lactones from Achillea ...
https://cherry.chem.bg.ac.rs/handle/123456789/384
Anti-mitotic activity of six Asteraceae plant extracts and identification of the sesquiterpene lactone hymenoratin from the...Anti-mitotic activity of six Asteraceae plant extracts and identification of the sesquiterpene lactone hymenoratin from the...
Anti-mitotic activity of six Asteraceae plant extracts and identification of the sesquiterpene lactone hymenoratin from the ... Anti-mitotic activity of six Asteraceae plant extracts and identification of the sesquiterpene lactone hymenoratin from the ... Biology-guided fractionation led to the purification of the active compound hymenoratin, a sesquiterpene lactone closely ... Investigation of the structure-activity relationship between sesquiterpene lactones and anti-mitotic activity is potentially ...
https://opus.uleth.ca/handle/10133/5298
Suppression of host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs after dual applications of...Suppression of host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs after dual applications of...
Polycyclic Sesquiterpenes * Sesquiterpenes * carvacrol * nootkatone Grant support * 1U01CK000105-1/CK/NCEZID CDC HHS/United ...
https://pubmed.ncbi.nlm.nih.gov/21510219/
4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis
Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an ... 4,5-SECO-GUAIANE AND A NINE-MEMBERED SESQUITERPENE LACTONE FROM HOLOSTYLIS RENIFORMIS Pereira, Marcos Donizete Peliçon et al. ... 4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis. Molecules. 2012, vol. 17, pp. 14046- ...
https://www.arca.fiocruz.br/handle/icict/7825
Plants | Free Full-Text | Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential...Plants | Free Full-Text | Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential...
... and other sesquiterpenes [64]; VvShirazTPS26 converts FPP into α-copaene, δ-cadinene, and other sesquiterpenes [65]. The TPSs ... The sesquiterpene volatiles synthesized through the MVA pathway ranged from 0.75 µg. g−1 FW (0317N) to 3.19 µg. g−1 FW (0306B ... The sesquiterpene volatile clusters were found to be highly correlated with their locations on the MVA synthesis pathway ( ... The HCA and heat map analysis of all the 14 sesquiterpenes (Supplementary Data S3) are presented in Figure 4a. Correlation ...
https://www.mdpi.com/2223-7747/11/19/2557
Clavo: MedlinePlus suplementosClavo: MedlinePlus suplementos
Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ...
https://medlineplus.gov/spanish/druginfo/natural/251.html
PDF] Engineering a mevalonate pathway in Escherichia coli for production of terpenoids | Semantic ScholarPDF] Engineering a mevalonate pathway in Escherichia coli for production of terpenoids | Semantic Scholar
Concentrations of amorphadiene, the sesquiterpene olefin precursor to artemisinin, reached 24 μg caryophyllene equivalent/ml. ... Metabolic engineering of sesquiterpene metabolism in yeast. *Shunji Takahashi, Y. Yeo, +6 authors. J. Chappell ... Engineering the lactococcal mevalonate pathway for increased sesquiterpene production.. *A. A. Song, J. Abdullah, +4 authors. R ... The in vivo synthesis of plant sesquiterpenes by Escherichia coli.. *V. Martin, Y. Yoshikuni, J. Keasling ...
https://www.semanticscholar.org/paper/Engineering-a-mevalonate-pathway-in-Escherichia-for-Martin-Pitera/141e76be66fc755778332dc9f1723fe2fe9eb235
PDF) Studies on Betula Essential OilsPDF) Studies on Betula Essential Oils
Twenty-seven compounds, mainly sesquiterpene hydrocarbons (78.7 %) and oxygenated sesquiterpenes (14.8 %), were identified ... The sesquiterpene from Juniperus oxycedrus L. (Cupressaceae), previously assigned as 15-hydroxy-9-epi-β-caryophyllene with the ... Known and new sesquiterpenes were isolated from Betula essential oils using column chromatographic techniques. Structure ... Known and new sesquiterpenes were isolated from Betula essential oils using column chromatographic techniques. Structure ...
https://www.researchgate.net/publication/233854780_Studies_on_Betula_Essential_Oils
PDF) Chemical composition and biological activities of essential Oil from leaf and bark of Nyctanthesarbor-tristis L. from NepalPDF) Chemical composition and biological activities of essential Oil from leaf and bark of Nyctanthesarbor-tristis L. from Nepal
Acyclic monoterpenes and sesquiterpenes showed increase in concentration when the leaves were exposed to γ-radiation. On the ... Acyclic monoterpenes and sesquiterpenes showed increase in concentration when the leaves were exposed to γ-radiation. On the ...
https://www.researchgate.net/publication/237067600_Chemical_composition_and_biological_activities_of_essential_Oil_from_leaf_and_bark_of_Nyctanthesarbor-tristis_L_from_Nepal
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...
Sesquiterpenes are the primary source of the pharmacologic effects of valerian.. Valerian produces dose-dependent sedation and ...
https://www.medscape.com/answers/1127055-156669/how-is-hypertension-addressed-during-the-dermatologic-preoperative-evaluation-and-management
Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the...Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the...
... are sesquiterpenes oxygenated, 33.43% are sesquiterpenes nonoxygenated, having as main constituents β-copaen-4-α-ol: 31.38%, ... sesquiterpenes nonoxygenated and 15.82% sesquiterpenes oxygenated, having as main constituent germacrene B: 21.53%. ... The volatile oil of P. aduncum L. was isolated in 0.35% and presented high concentration of sesquiterpenes nonoxygenated (45.45 ... sesquiterpenes (germacrene B, germacrene D, α-humulene, β-copaen-4-α-ol) , phenylpropanoids (humulene epoxide II, muurola-4,10( ...
https://www.degruyter.com/document/doi/10.1515/znc-2020-0045/html
LactonesLactoneMonoterpenes and sesquiterpenesCompoundsConstituentsPhenylpropanoidsLignansSynthaseHydrocarbonCompoundPrecursorYeastMetabolicCharacterizationBetulaIsomersAlcoholCedarDerivativesActivityEssential oilProductionNaturalFoundDiscovery
Lactones6
  • Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. (ac.rs)
  • TY - JOUR AU - Aljančić, Ivana AU - Vajs, Vlatka AU - Menković, N. AU - Karadžić, Ivanka M. AU - Juranić, N. AU - Milosavljevic, S AU - Macura, S. PY - 1999 UR - https://cherry.chem.bg.ac.rs/handle/123456789/384 AB - Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. (ac.rs)
  • Investigation of the structure-activity relationship between sesquiterpene lactones and anti-mitotic activity is potentially useful to understand unknown biological mechanisms or to develop anticancer drug candidates. (uleth.ca)
  • Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L. (europa.eu)
  • Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice. (univr.it)
  • Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention. (who.int)
Lactone4
  • Biology-guided fractionation led to the purification of the active compound hymenoratin, a sesquiterpene lactone closely related to pulchelloid A, which was isolated from the anti-mitotic plant Gaillardia aristata. (uleth.ca)
  • Synergistic effect of the HDAC inhibitor SAHA and the sesquiterpene lactone parthenolide in triple negative breast cancer cells. (unipa.it)
  • For the first time, in 1972, ART or qinghaosu was isolated from the leaves of the plant, Aretemisia annua, by Chinese researchers, as a sesquiterpene lactone. (avensonline.org)
  • The only problem with permethrin would be with patients who have allergy to sesquiterpene lactone allergens (Chrysanthemum, ragweed, sunflower, artichoke, arnica, daisy, marigold plants) as there is cross react with permethrin. (typepad.com)
Monoterpenes and sesquiterpenes3
  • Biogenic SOA precursors are isoprene, monoterpenes and sesquiterpenes. (psi.ch)
  • This essential oil is high in monoterpenes and sesquiterpenes, known as antioxidants. (nexusmagazine.com)
  • These oils are complex mixtures of organic compounds, including monoterpenes and sesquiterpenes. (aromaticscience.com)
Compounds9
  • Microbial cells engineered for efficient production of plant sesquiterpenes may allow for a sustainable and scalable production of these compounds. (chalmers.se)
  • In particular, sesquiterpene compounds (C 15 ), such as farnesene and bisabolene, have been identified as promising jet fuel candidates. (escholarship.org)
  • Yu, Z 2010, ' Anticancer effects and mechanisms of sesquiterpene compounds isolated from Atractylodes Macrocephala in B16 melanoma cells ', The 9th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM) = 第九屆中藥全球化聯盟國際研討會, 23/08/10 - 25/08/10 pp. (edu.hk)
  • In a previous study, researchers involved with the ICBG discovered eight novel compounds - prototypic sesquiterpenes - that exhibit anti-HIV activities. (naturalnews.com)
  • That is because it contains helpful compounds such as sesquiterpenes and terpenes. (trustedhealthproducts.com)
  • The species, Cedrus atlantica , the atlas cedar, is probably the closest known relative of this cedar and is exceptionally rich in aromatic compounds known as sesquiterpenes. (dgaryyoung.com)
  • Sesquiterpenes are compounds that have a unique stimulating effect on the limbic region of the brain, including the amygdala, the center of emotions and memory. (dgaryyoung.com)
  • A wide range of chemical compounds including monoterpene, sesquiterpenes, and phenylpropanoids have been isolated from this plant. (hindawi.com)
  • Nerolidol belongs to the sesquiterpene chemical family, a group of compounds that are less volatile and more pungent than other terpenes. (cibdol.com)
Constituents2
  • Sesquiterpenes are constituents of a variety of essential oils that are used in flavorings, perfumes, personal care, and cleaning products. (cdc.gov)
  • The bark contains several medically active constituents, including mucilage, carotenoids, sesquiterpenes and anthocyanidins[279]. (pfaf.org)
Phenylpropanoids1
  • These results indicate that phenylpropanoids and sesquiterpenes present in essential oils contribute to their antiviral activity against HSV [herpes simplex virus]. (oil-testimonials.com)
Lignans1
  • To further explore the antiviral properties of L. verticillata , the researchers evaluated several relatively abundant isolates, including a litseane compound, two eudesmane sesquiterpenes, and three lignans by testing them against an additional 21 viral targets. (naturalnews.com)
Synthase3
  • The SCO5222 protein is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate to t. (swan.ac.uk)
  • The SCO5222 protein is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate to the novel tricyclic hydrocarbon, epi-isozizaene (Lin, X., Hopson, R., and Cane, D. E. (2006) J. Am. Chem. (swan.ac.uk)
  • The introduction of heterologous mevalonate pathway-based genes into E. coli has been shown to improve the productivity of carotenoids or sesquiterpenes that are synthesized from farnesyl diphosphate and enables relevant researchers to efficiently analyze an isolated gene candidate for a terpene synthase (terpene cyclase). (semanticscholar.org)
Hydrocarbon3
  • The hydrocarbon α-santalene is a precursor of sesquiterpenes with relevant commercial application and was selected as case study. (chalmers.se)
  • The sesquiterpene hydrocarbon (E)-(1R,9S)-caryophyllene was identified as the only other major component in the oils (8.05% and 13.19% by GC, respectively). (permaculturenews.org)
  • Mandarin is renowned for its uplifting and calming effects, while cedarwood contains the highest amount of sesquiterpenes - a hydrocarbon group found in essential oils - which seem to stimulate the brain's limbic system and apparently help to elevate mood and relaxation. (perfumesociety.org)
Compound3
  • It was possible to divert the carbon flux toward the sesquiterpene compound, and the resulting strain shows a 88-fold improvement in α-santalene productivity. (chalmers.se)
  • The projection representation of the EO chemical classes in both evaluated periods indicated that oxygenated sesquiterpenes are the major compound class (46.99% in dormancy) and (43.59% in budding). (bvsalud.org)
  • This Sandalwood essential oil is rich in sesquiterpene alpha-santalol - a compound that gives viscosity and a woody aroma responsible for much of its therapeutic and biological effects. (highaltitudecosmeceuticals.com)
Precursor1
  • Renewable production of high density jet fuel precursor sesquiterpenes from Escherichia coli. (escholarship.org)
Yeast2
  • The results obtained illustrate how the synergistic application of multilevel metabolic engineering and bioprocess engineering can be used to obtain a significant amount of high value sesquiterpene in yeast. (chalmers.se)
  • This represents a starting point toward the construction of a yeast "sesquiterpene production factory" and for the development of an economically viable bio-based process that has the potential to replace the current production methods. (chalmers.se)
Metabolic1
  • Successively, a rationally designed metabolic control strategy with the aim to dynamically modulate a key metabolic step to achieve optimal sesquiterpene production was applied, combined with the engineering of the main regulatory checkpoint of targeted pathway. (chalmers.se)
Characterization1
  • A fast and reproducible protocol was established for enzymatic characterization of plant sesquiterpene synthases that can incorporate radioactivity in their products. (chemie.de)
Betula2
  • Known and new sesquiterpenes were isolated from Betula essential oils using column chromatographic techniques. (researchgate.net)
  • Here we studied downy birch ( Betula pubescens ) emissions, and especially sesquiterpene and oxygenated sesquiterpene emissions were found to be high. (copernicus.org)
Isomers1
  • Along with α-Cedrene, β-Cedrene is one of two isomers that form Cedrene, a sesquiterpene derived from the essential oils of cedar. (eybna.com)
Alcohol1
  • Carotol is a sesquiterpene alcohol that makes up about 40% of carrot seed oil. (earthtokathy.com)
Cedar1
Derivatives1
  • A seco -laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada. (nature.com)
Activity1
  • It is very intriguing to note that many of the oils selected by the ancient people in biblical times were oils that contain high levels of sesquiterpene activity. (dgaryyoung.com)
Essential oil1
  • Tricyclic sesquiterpenes from the root essential oil of Echinops giganteus var. (nist.gov)
Production1
  • Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. (semanticscholar.org)
Natural1
  • Sesquiterpenes are a class of natural products with a diverse range of attractive industrial proprieties. (chalmers.se)
Found1
  • We performed a computational analysis to calculate the energy of combustion of these sesquiterpenes and found that their specific energies are comparable to commercial jet fuel A-1. (escholarship.org)
Discovery1
  • Bioactivity-guided isolation of Aspergillus ustus led to the discovery of five new drimane sesquiterpenes, named ustusal A, ustusolate F and G, and ustusoic acid A and B, 1-5 respectively. (olmdiagnostics.com)
Browsing by Subject Sesquiterpenes
Browsing by Subject "Sesquiterpenes" (extranet.who.int)
Frontiers | A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of...
Frontiers | A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of... (frontiersin.org)
Sesquiterpenes Archives - Nature's Gift
Sesquiterpenes Archives - Nature's Gift (naturesgift.com)
Plants | Free Full-Text | Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential...
Plants | Free Full-Text | Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential... (mdpi.com)
Clavo: MedlinePlus suplementos
Clavo: MedlinePlus suplementos (medlineplus.gov)
WHO Informal Consultation on Clinical Neurological Investigations Required for Patients Treated with Artemisinin Compounds and...
WHO Informal Consultation on Clinical Neurological Investigations Required for Patients Treated with Artemisinin Compounds and... (extranet.who.int)
Analyse coût-efficacité de l' utilisation de l' artésunate et de la quinine + tétracycline pour le traitement du paludisme...
Analyse coût-efficacité de l' utilisation de l' artésunate et de la quinine + tétracycline pour le traitement du paludisme... (extranet.who.int)
Sensibilité de Plasmodium falciparum à l' artésunate in vitro / C. Wongsrichanalai ... [‎et al.]‎
Sensibilité de Plasmodium falciparum à l' artésunate in vitro / C. Wongsrichanalai ... [‎et al.]‎ (extranet.who.int)
PDF] Engineering a mevalonate pathway in Escherichia coli for production of terpenoids | Semantic Scholar
PDF] Engineering a mevalonate pathway in Escherichia coli for production of terpenoids | Semantic Scholar (semanticscholar.org)
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by... (medscape.com)
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by...
Dermatologic Preoperative Evaluation and Management: Overview, General Health Assessment, Assessment of Operative Risk by... (medscape.com)
PDF) Chemical composition and biological activities of essential Oil from leaf and bark of Nyctanthesarbor-tristis L. from Nepal
PDF) Chemical composition and biological activities of essential Oil from leaf and bark of Nyctanthesarbor-tristis L. from Nepal (researchgate.net)
Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the...
Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the... (degruyter.com)
Plants from the laurel family found to exhibit potent antiviral properties - NaturalNews.com
Plants from the laurel family found to exhibit potent antiviral properties - NaturalNews.com (naturalnews.com)
Breath Test May Diagnose Fungal Pneumonia
Breath Test May Diagnose Fungal Pneumonia (medscape.com)
PDF) Studies on Betula Essential Oils
PDF) Studies on Betula Essential Oils (researchgate.net)
Mirra - Wikipedia
Mirra - Wikipedia (it.wikipedia.org)
FARMACIA Y BIOQUIMICA - Research output - San Luis Gonzaga National University of Ica
FARMACIA Y BIOQUIMICA - Research output - San Luis Gonzaga National University of Ica (cris.unica.edu.pe)
Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis<...
Production of Plant Sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 Repression on Sesquiterpene Biosynthesis<... (orbit.dtu.dk)
Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family | Scientific Reports
Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family | Scientific Reports (nature.com)
Begriffe mit S | Medizin-Lexikon | gesundheit.de
Begriffe mit S | Medizin-Lexikon | gesundheit.de (gesundheit.de)
DoTERRA Black Pepper essential oil - Nexus Magazine
DoTERRA Black Pepper essential oil - Nexus Magazine (nexusmagazine.com)
MeSH Browser
MeSH Browser (meshb.nlm.nih.gov)
Chuchuhuasi: Health Benefits, Side Effects, Uses, Dose & Precautions
Chuchuhuasi: Health Benefits, Side Effects, Uses, Dose & Precautions (rxlist.com)
Indica and Sativa Labels Can't Be Trusted, Study Indicates | High Times
Indica and Sativa Labels Can't Be Trusted, Study Indicates | High Times (hightimes.com)
Stinking Fleabane - Dittrichia graveolens | North Carolina Extension Gardener Plant Toolbox
Stinking Fleabane - Dittrichia graveolens | North Carolina Extension Gardener Plant Toolbox (plants.ces.ncsu.edu)