Serum Globulins
Hepatitis A
Immune Sera
Sex Hormone-Binding Globulin
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Transport of solutes through cartilage: permeability to large molecules. (1/352)
A review of the transport of solutes through articular cartilage is given, with special reference to the effect of variations in matrix composition. Some physiological implications of our findings are discussed. Also, results of an experimental study of the permeability of articular cartilage to large globular proteins are presented. Because of the very low partition coefficients of large solutes between cartilage and an external solution new experimental techniques had to be devised, particularly for the study of diffusion. The partition coefficients of solutes were found to decrease very steeply with increase in size, up to serum albumin. There was, however, no further decrease for IGG. The diffusion coefficient of serum albumin in cartilage was relatively high (one quarter of the value in aqueous solution). These two facts taken together suggest that there may be a very small fraction of relatively large pores in cartilage through which the transport of large molecules is taking place. The permeability of cartilage to large molecules is extremely sensitive to variations in the glycosaminoglycan content: for a threefold increase in the latter there is a hundredfold decrease in the partition coefficient. For cartilage of fixed charge density around 0-19 m-equiv/g, there is no penetration at all of globular proteins of size equal to or larger than serum albumin. (+info)Decreased anion gap associated with monoclonal and pseudomonoclonal gammopathy. (2/352)
Nine patients with monoclonal and one with pseudomonoclonal gammopathy were found to have a decreased anion gap. Eight of the patients had multiple myeloma, one has plasma cell leukemia and one had chronic active hepatitis. In all of the the decreased anion gap was associated with an increased concentration of IgG greater than 5 g/dl. (+info)Fibrinolytic properties of activated FXII. (3/352)
Activated factor XII (FXIIa), the initiator of the contact activation system, has been shown to activate plasminogen in a purified system. However, the quantitative role of FXIIa as a plasminogen activator in contact activation-dependent fibrinolysis in plasma is still unclear. In this study, the plasminogen activator (PA) activity of FXIIa was examined both in a purified system and in a dextran sulfate euglobulin fraction of plasma by measuring fibrinolysis in a fibrin microtiter plate assay. FXIIa was found to have low PA activity in a purified system. Dextran sulfate potentiated the PA activity of FXIIa about sixfold, but had no effect on the PA activity of smaller fragments of FXIIa, missing the binding domain for negatively charged surfaces. The addition of small amounts of factor XII (FXII) to FXII-deficient plasma induced a large increase in contact activation-dependent PA activity, as measured in a dextran sulfate euglobulin fraction, which may be ascribed to FXII-dependent activation of plasminogen activators like prekallikrein. When more FXII was added, PA activity continued to increase but to a lesser extent. In normal plasma, the addition of FXII also resulted in an increase of contact activation-dependent PA activity. These findings suggested a significant contribution of FXIIa as a direct plasminogen activator. Indeed, at least 20% of contact activation-dependent PA activity could be extracted from a dextran sulfate euglobulin fraction prepared from normal plasma by immunodepletion of FXIIa and therefore be ascribed to direct PA activity of FXIIa. PA activity of endogenous FXIIa immunoadsorped from plasma could only be detected in the presence of dextran sulfate. From these results it is concluded that FXIIa can contribute significantly to fibrinolysis as a plasminogen activator in the presence of a potentiating surface. (+info)alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. (4/352)
Mice deficient in either or both mouse alpha2-macroglobulin (MAM) and murinoglobulin-1 (MUG1) were generated and proved phenotypically normal under standard conditions. Acute pancreatitis was induced with a diet deficient in choline and methionine, supplemented with ethionine. The mortality was less than 25% in wild-type mice, as opposed to at least 56% in knockout mice, and was highest (70%) in MAM-/- mice, with earliest onset at 2 days. Plasma amylase and lipase levels were increased, but pancreatic tissue appeared histologically variable in individual mice. The clinical symptoms were most severe in MAM-/- mice and, surprisingly, were not aggravated in the double knockout mice, suggesting that the lack of proteinase inhibition capacity was not the major problem. Therefore, we analyzed the expression of 21 different cytokines and polypeptide factors in the pancreas of all experimental groups of mice. Interleukin-1-receptor antagonist mRNA was consistently induced by the diet in the pancreas of MAM-/- mice, and transforming growth factor-beta, tumor necrosis factor-alpha, tumor necrosis factor-beta, beta-lymphotoxin, and interferon-gamma mRNA levels were also increased. The data demonstrate the important role of alpha2-macroglobulin (A2M) in acute pancreatitis as both a proteinase inhibitor and a cytokine carrier. Mice deficient in MAM and/or MUG thus offer new experimental models for defining in vivo the role of the macroglobulins in pancreatitis and in other normal and pathological processes. (+info)Association of plasma IgM with body size, histopathologic changes, and plasma chemistries in adult Pacific herring Clupea pallasi. (5/352)
Pacific herring Clupea pallasi immunoglobulin is an IgM-like molecule comprised of heavy and light chains with molecular weights of 79 and 25 to 27 kD, respectively. Purified immunoglobulin was used to generate highly specific polyclonal antibodies for development of a sandwich ELISA. The ELISA was used to quantify total plasma IgM in 602 Pacific herring captured in Prince William Sound and Sitka Sound, Alaska, USA. Plasma IgM concentrations ranged from 0.13 to 5.32 mg ml-1. Using multiple stepwise regression analysis, plasma IgM was highly correlated (p < or = 0.01) with body length, Ichthyophonus hoferi infection, plasma albumin, plasma cholesterol, liver macrophage aggregates, and focal skin reddening. I. hoferi was the only organism significantly associated with plasma IgM. Gender, site, and season (spring vs fall) did not contribute to significant differences in plasma IgM. This study contributes to the understanding of the interaction of body size, plasma chemistries, and pathological changes upon circulating immunoglobulins in fish. (+info)Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. (6/352)
We previously demonstrated that bovine serum conglutinin has markedly greater ability to inhibit influenza A virus (IAV) infectivity than other collectins. We now show that recombinant conglutinin and a chimeric protein containing the NH(2) terminus and collagen domain of rat pulmonary surfactant protein D (rSP-D) fused to the neck region and carbohydrate recognition domain (CRD) of conglutinin (termed SP-D/Cong(neck+CRD)) have markedly greater ability to inhibit infectivity of IAV than wild-type recombinant rSP-D, confirming that the potent IAV-neutralizing activity of conglutinin resides in its neck region and CRD. Furthermore, by virtue of incorporation of the NH(2) terminus and collagen domain of SP-D, SP-D/Cong(neck+CRD) caused substantially greater aggregation of IAV particles and enhancement of neutrophil binding of, and H(2)O(2) responses to, IAV than recombinant conglutinin or recombinant rSP-D. Hence, SP-D/Cong(neck+CRD) combined favorable antiviral and opsonic properties of conglutinin and SP-D. This study demonstrates an association of specific structural domains of SP-D and conglutinin with specific functional properties and illustrates that antimicrobial activities of wild-type collectins can be enhanced through recombinant strategies. (+info)Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta. (7/352)
alpha(2)-Macroglobulin (alpha(2)M) functions as a proteinase inhibitor and as a carrier of diverse growth factors. In this study, we localized binding sites for platelet-derived growth factor-BB (PDGF-BB) and nerve growth factor-beta (NGF-beta) to a linear sequence in the 180-kDa human alpha(2)M subunit which includes amino acids 591-774. A glutathione S-transferase fusion protein containing amino acids 591-774 (FP3) bound PDGF-BB and NGF-beta in ligand blotting assays whereas five other fusion proteins, which collectively include amino acids 99-590 and 775-1451 did not. The K(D) values for PDGF-BB and NGF-beta binding to immobilized FP3 were 300 +/- 40 and 180 +/- 30 nM, respectively; these values were comparable with those determined using methylamine-modified alpha(2)M, suggesting that higher-order alpha(2)M structure is not necessary for PDGF-BB and NGF-beta binding. PDGF-BB and NGF-beta blocked the binding of transforming growth factor-beta1 (TGF-beta1) to FP3. Furthermore, murinoglobulin, which is the only known member of the alpha-macroglobulin family that does not bind TGF-beta, also failed to bind PDGF-BB and NGF-beta. These results support the hypothesis that either a single linear sequence in human alpha(2)M or overlapping sequences are responsible for the binding of TGF-beta, PDGF-BB, and NGF-beta, even though there is minimal sequence identity between these three growth factors. FP3 blocked the binding of PDGF-BB to a purified chimeric protein, in which the extracellular domain of the PDGF beta receptor was fused to the IgG(1) Fc domain, and to PDGF receptors on NIH 3T3 cells. Thus, FP3 may inhibit the activity of PDGF-BB. (+info)Photoaffinity glycoprobes-a new tool for the identification of lectins. (8/352)
One of the proposed functions for the carbohydrate structures on glycoconjugates is the transfer of information through interaction with specific lectin receptors. However, the number of elucidated functional lectin-carbohydrate interactions is still relatively small, largely due to the lack of adequate methods to identify lectin activity in complex biological samples. Aiming to solve this problem, we have developed a method based on the novel group of compounds we named glycoprobes. The glycoprobe consists of three vital parts: (1) glycan, (2) digoxin tag, and (3) photoreactive crosslinker. When incubated in dark, oligosaccharide part of the glycoprobe forms a complex with lectin. After illumination, covalent link between the probe and the lectin is formed resulting in a digoxin-tagged lectin. Using antibodies against digoxin, this complex can easily be identified immuno/cytochemically, or by Western blots. To demonstrate the applicability of glycoprobes we have used Man(9)-glycoprobe (containing Man(9)oligosaccharide) and YEE(ahGalNAc)(3)-glycoprobe (containing a synthetic neoglycopeptide with three terminal N-acetyl-galactosamine residues; Lee and Lee, Glycoconjugate J., 1987,4, 317) to identify lectins in bovine serum and rat liver membranes. The simplicity of the method enables its application in routine monitoring of changes in lectin activity during various developmental or pathological processes. An example of GalNAc-binding analysis in human serum is shown. (+info) Hepatitis A is an acute and highly contagious liver disease caused by the hepatitis A virus (HAV). It primarily affects the liver and can cause a range of symptoms, including fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, and yellowing of the skin and eyes (jaundice).
Hepatitis A is typically spread through contaminated food and water or through close contact with someone who has the infection. The virus can also be spread through sexual contact or sharing of needles.
Symptoms of hepatitis A usually appear two to six weeks after exposure and can last for several weeks or months. In some cases, the infection can lead to complications such as liver failure, which can be life-threatening.
There is a vaccine available for hepatitis A, which is recommended for individuals traveling to areas where the virus is common, people who engage in high-risk behaviors, and those with chronic liver disease. Treatment for hepatitis A typically focuses on relieving symptoms and supporting the liver as it recovers. In severe cases, hospitalization may be necessary.
Preventive measures to reduce the risk of hepatitis A infection include maintaining good hygiene practices, such as washing hands frequently, especially before eating or preparing food; avoiding consumption of raw or undercooked shellfish, particularly oysters; and avoiding close contact with people who have the infection.
Cirrhosis
Findings include elevations in serum globulins, especially gamma globulins. Hereditary hemochromatosis usually presents with ... Globulins increase due to shunting of bacterial antigens away from the liver to lymphoid tissue. Serum sodium levels fall( ... Human serum albumin solution is usually given to prevent complications from the rapid volume reduction. In addition to being ... July 2014). "Serum ferritin predicts early mortality in patients with decompensated cirrhosis". Journal of Hepatology. 61 (1): ...
Walter Ruggles Campbell
Campbell, Walter R.; Hanna, Marion I. (1937). "The Albumin, Globulins, and Fibrinogen of Serum and Plasma". Journal of ... When Banting brought over the brownish grey liquid, 7.5 ml of McLeod's serum (which is what it was called in the orders) was ... Dauphinee, James A.; Campbell, W.R. (1948). "Serum Proteins in Hepatic Disease". Medical Clinics of North America. 32 (2): 455- ...
Human serum albumin
Busher JT (1990). "Chapter 101: Serum Albumin and Globulin". In Walker HK, Hall WD, Hurst JW (eds.). Clinical methods : the ... Human serum albumin is the serum albumin found in human blood. It is the most abundant protein in human blood plasma; it ... The reference range for albumin concentrations in serum is approximately 35-50 g/L (3.5-5.0 g/dL). It has a serum half-life of ... Bovine serum albumin Serum albumin GRCh38: Ensembl release 89: ENSG00000163631 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
Autoimmune pancreatitis
Increased serum levels of gamma globulins, immunoglobulin G (IgG) or IgG4. The presence of serum autoantibodies such as anti- ... Laboratory data demonstrate abnormally elevated levels of serum gamma globulin and/or IgG, or the presence of autoantibodies. ... serum IgG4 level, other organ involvement with IgG4-related disease, pancreatic histology and response to steroid therapy. In ...
Edestin
... is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human ... and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins, and Gamma globulins) are long peptide chains, precursors for ... "A haemoglobin-binding beta-globulin in human serum". Nature. 186 (4730): 1055-6. Bibcode:1960Natur.186.1055T. doi:10.1038/ ... "Protein - Proteins of the blood serum , Britannica". Nixdorff KK, Schlecht S, Rüde E, Westphal O (1975). "Immunological ...
Humoral immunity
The proteins account for 5% of the serum globulin fraction. Most of these proteins circulate as zymogens, which are inactive ... In 1890, Buchner described alexins as "protective substances" that exist in the blood serum and other bodily fluids and are ... The concept of humoral immunity developed based on the analysis of antibacterial activity of the serum components. Hans Buchner ... were used to vaccinate animals in an attempt to demonstrate that immunized serum contained an antitoxin that could neutralize ...
Serum total protein
Protein in the serum is made up of albumin and globulin. The globulin in turn is made up of α1, α2, β, and γ globulins. These ... Serum total protein, also known as total protein, is a biochemical test for measuring the total amount of protein in serum. ... "What Is a Total Serum Protein Test?". WebMD. "Harmonisation of Reference Intervals" (PDF). Pathology Harmony (UK). Archived ...
Alpha-1 antitrypsin deficiency
Laurell CB, Eriksson S (1963). "The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency". Scand J ... of normal serum level of A1AT PiSS: 60% of normal serum level of A1AT PiMZ: 60% of normal serum level of A1AT PiSZ: 40% of ... The initial test performed is serum A1AT level. A low level of A1AT confirms the diagnosis and further assessment with A1AT ... The serum levels of some of the common genotypes are:[citation needed] PiMM: 100% (normal) PiMS: 80% ...
Serpin
"Zur Kenntnis der alpha-globulin des menschlichen normal serums" [For knowledge of the alpha - globulin of human normal serums ... Laurell CB, Eriksson S (March 2013). "The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963". ... thyroxine-binding globulin, cortisol-binding globulin) and molecular chaperoning (HSP47). The term serpin is used to describe ... Thyroxine-binding globulin and transcortin transport the hormones thyroxine and cortisol, respectively. The non-inhibitory ...
Gamma globulin
Gamma globulins are a class of globulins, identified by their position after serum protein electrophoresis. The most ... although some immunoglobulins are not gamma globulins, and some gamma globulins are not immunoglobulins. Gamma globulin ... Overloading the degradation mechanism causes the harmful gamma globulins to have a much shorter half of the life in sera. ... In 1953, gamma globulin was shown to prevent paralytic polio. Being a product derived from bone marrow and lymph gland cells, ...
Felix Haurowitz
He was among the first researchers to provide convincing evidence that antibodies are serum globulins. In 1938 he made the ... Breinl, Friedrich; Haurowitz, Felix (1930). "Chemische Untersuchung des Präzipitates aus Hämoglobin und Anti-Hämoglobin-Serum ...
Anordrin
Song S, Chen JK, He ML, Zuo SH, Fotherby K (1987). "Effect of Anordrin on serum levels of sex hormone binding globulin, ...
Hapten
The most common carriers include serum globulin, albumins, ovalbumin and many others. Although proteins are mostly employed for ...
Complement system
They account for about 10% of the globulin fraction of blood serum. Three biochemical pathways activate the complement system: ... Heating the serum destroyed its killing activity. Nevertheless, the heat-inactivated serum, when injected into guinea pigs ... From p. 483: "Es sprechen diese Versuche nach unseren früheren Erfahrungen dafür, dass auch hier in dem Serum ein Analogon des ... In 1888, George Nuttall found that sheep blood serum had mild killing activity against the bacterium that causes anthrax. The ...
Benign prostatic hyperplasia
Ansari MA, Begum D, Islam F (2008). "Serum sex steroids, gonadotrophins and sex hormone-binding globulin in prostatic ... Roberts RO, Jacobson DJ, Rhodes T, Klee GG, Leiber MM, Jacobsen SJ (October 2004). "Serum sex hormones and measures of benign ... One small study has shown that medical castration lowers the serum and prostate hormone levels unevenly, having less effect on ... If confirmed, this mechanism explains why serum androgen levels do not seem to correlate with BPH and why giving exogenous ...
Gel electrophoresis of proteins
... serum albumin and globulin. They are generally equal in proportion, but albumin as a molecule is much smaller and lightly, ... 2, Method and application to human serum proteins". Ann. N. Y. Acad. Sci. 121 (2): 404-427. Bibcode:1964NYASA.121..404D. doi: ... The globulins are classified by their banding pattern (with their main representatives):[citation needed] The alpha (α) band ... protein electrophoresis is a method of analysing the proteins mainly in blood serum. Before the widespread use of gel ...
Angiotensin
It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in ... Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as ...
Liver disease
serum proteins, serum albumin, serum globulin, alanine transaminase, aspartate transaminase, prothrombin time, partial ...
Estramustine phosphate
"Effects of diethylstilbestrol and estramustine phosphate on serum sex hormone binding globulin and testosterone levels in ... greatly increased levels of sex hormone-binding globulin and hence a decreased fraction of free androgens in the circulation; ...
Management of hair loss
Some popular plant juices sold as hair serum may instead of growing human hair actually inhibit the growth, including 6- ... sex hormone-binding globulin levels, hair shaft diameter, and sexual function". Fertility and Sterility. 93 (6): 1997-2003. doi ... Kovalevsky G, Ballagh SA, Stanczyk FZ, Lee J, Cooper J, Archer DF (April 2010). "Levonorgestrel effects on serum androgens, ...
Arthur J. Ammann
Immune Globulin Levels in Colostrum and Breast Milk, and Serum From Formula- and Breast-Fed Newborns. Proc Soc Exp Biol Med, ... "Immune globulin levels in colostrum and breast milk and serum from formula and breast-fed newborns."[permanent dead link] Proc ...
Jehovah's Witnesses
p. 1. Examples of permitted fractions are: Interferon, Immune Serum Globulins Archived January 6, 2008, at the Wayback Machine ...
Passive immunity
There is also a potential risk for hypersensitivity reactions, and serum sickness, especially from gamma globulin of non-human ... Immune globulin or immunoglobulin has been used to both prevent and treat reactivation of the herpes simplex virus (HSV), ... Since the 1960s, human tetanus immune globulin (TIG) has been used in the United States in unimmunized, vaccine-naive or ... Patients who are immunized with the antibodies from animals may develop serum sickness due to the proteins from the immune ...
Cohn process
Human blood plasma fractionation yielded human serum albumin, serum gamma globulin, fibrinogen, thrombin, and blood group ... Gamma globulins are found in Fractions II and III and proved to be essential in treating measles for soldiers. Gamma globulin ... Most importantly, the gamma globulins were useful in modifying and preventing infectious hepatitis during the Second World War ... "Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and ...
Coombs test
The serum is incubated with foreign red blood cells of known antigenicity. Finally, anti-human globulin is added. If ... By diluting a serum containing antibodies the quantity of the antibody in the serum can be gauged. This is done by performing ... Coombs reagent is antihuman globulin. It is made by injecting human globulin into animals, which produce polyclonal antibodies ... removing the patient's own serum) and then centrifuged with antihuman globulin (also known as Coombs reagent). If ...
Iodine deficiency in China
Iodine deficiency, hypothyroidism, and low serum concentrations of thyroxine-binding globulin were significantly related to ...
Medroxyprogesterone acetate
... effect of megestrol acetate and medroxyprogesterone acetate on serum estrone sulfate and sex hormone binding globulin". J ... Lundgren S, Lønning PE, Utaaker E, Aakvaag A, Kvinnsland S (June 1990). "Influence of progestins on serum hormone levels in ... Hiroi, M.; Stanczyk, F.Z.; Goebelsmann, U.; Brenner, P.F.; Lumkin, M.E.; Mishell, D.R. (1975). "Radioimmunoassay of serum ... Nachtigall LE, Raju U, Banerjee S, Wan L, Levitz M (2000). "Serum estradiol-binding profiles in postmenopausal women undergoing ...
Lymphangiectasia
... chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein- ... With a very low serum albumin, transfusion with blood plasma or an infusion of hetastarch may be necessary to treat the signs ...
Aflatoxin B1
Studies in fish showed aflatoxin B1 to have significant immunosuppressive effects including reduced serum total globulin and ...
List of dog diseases
... is an intestinal disease of dogs characterized by chronic diarrhea and loss of proteins such as serum albumin and globulin. It ...
2022 monkeypox outbreak
A short review suggests supportive care may typically be sufficient and that several antivirals and vaccinia immune globulin ... "Internationalt udbrud af abekopper (monkeypox)". Statens Serum Institut (in Danish). Retrieved 18 October 2022. "Denmark ... Antiviral drugs, cidofovir and tecovirimat, vaccinia immune globulin and the smallpox vaccine may be used during outbreaks. The ... Statens Serum Institut. 23 May 2022. Archived from the original on 24 May 2022. Retrieved 23 May 2022. "Czech Republic detects ...
Selective androgen receptor modulator
... there was a statistically significant lowering of Sex Hormone-Binding Globulin (SHBG) and serum total testosterone levels. ...
Thyroxine-binding globulin
The patient's serum is mixed with the labeled thyroid hormone; next, the resin is added to the whole mixture to measure the ... Thyroxine-binding globulin (TBG) is a globulin protein that in humans is encoded by the SERPINA7 gene. TBG binds thyroid ... Thyroxine-binding globulin tests are sometimes used to find the cause of raised or lowered levels of thyroid hormone. This is ... 1993). "Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its ...
Levothyroxine
Doses of levothyroxine that normalize serum TSH may not normalize abnormal levels of LDL cholesterol and total cholesterol. ... Greater than 99% of circulating thyroid hormones are bound to plasma proteins including thyroxine-binding globulin, ...
Allylestrenol
Noguchi K, Suzuki K, Teranishi J, Kondo K, Kishida T, Saito K, Uemura H, Kubota Y (July 2006). "Recovery of serum prostate ... of the affinity of testosterone for sex hormone-binding globulin (SHBG). Conversely, its metabolite 17α-allyl-19- ...
Waldenström macroglobulinemia
Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM. An M ... and an albumin-to-globulin ratio. The ESR and uric acid level may be elevated. Creatinine is occasionally elevated and ... An additional predictive factor is elevated serum lactate dehydrogenase (LDH). Of cancers involving the lymphocytes, 1% of ... High-resolution electrophoresis and serum and urine immunofixation are recommended to help identify and characterize the ...
Alpha-1 antitrypsin
... of normal serum level of A1AT PiSS: 60% of normal serum level of A1AT PiMZ: 60% of normal serum level of A1AT PiSZ: 40% of ... The non-albumin proteins are referred to as globulins. The alpha region can be further divided into two sub-regions, termed "1 ... The level of A1AT in serum is most often determined by adding an antibody that binds to A1AT, then using turbidimetry to ... The serum levels of some of the common genotypes are: PiMM: 100% (normal) PiMS: 80% ...
Biomolecular condensate
... of the mammary gland Serum albumin and globulins Secreted lysozyme Typical organelles or endosomes enclosed by a lipid bilayer ... WB Hardy linked formation of biological colloids with phase separation in his study of globulins, stating that: "The globulin ... The globulins". The Journal of Physiology. 33 (4-5): 251-337. doi:10.1113/jphysiol.1905.sp001126. PMC 1465795. PMID 16992817. ...
Hyperimmunoglobulin E syndrome
High-dose intravenous gamma-globulin has also been suggested for the treatment of severe eczema in patients with HIES and ... described two boys with similar symptoms as well as coarse facies, eosinophilia, and elevated serum IgE levels. These two ... Kimata H (March 1995). "High-dose intravenous gamma-globulin treatment for hyperimmunoglobulinemia E syndrome". The Journal of ... concentrations of the serum antibody IgE. Inheritance can be autosomal dominant or autosomal recessive. Many patients with ...
Scarlet fever
Karelitz and Stempien discovered that extracts from human serum globulin and placental globulin can be used as lightening ... Scarlet fever serum from horses' blood was used in the treatment of children beginning in 1900 and reduced mortality rates ... "A Scarlet Fever Serum" (PDF). New York Times. 3 November 1902. p. 8. Archived (PDF) from the original on 25 February 2021. ... Several antitoxic serums were produced before antibiotics; however, it was never made in sufficient quantities, and could not ...
Effects of hormones on sexual motivation
changes in serum levels of the aminotransferases [11] or side effects (stomach pain, headache, dry skin, nausea, increased ... and the typical doses of ethinylestradiol present in combined birth control pills increase sex hormone-binding globulin (SHBG) ...
Estetrol
Hammond GL, Hogeveen KN, Visser M, Coelingh Bennink HJ (2008). "Estetrol does not bind sex hormone binding globulin or increase ... Kundu N, Wachs M, Iverson GB, Petersen LP (September 1981). "Comparison of serum unconjugated estriol and estetrol in normal ... September 2014). "Effect of estetrol administration on brain and serum allopregnanolone in intact and ovariectomized rats". The ... Kundu N, Grant M (June 1976). "Radioimmunoassay of 15alpha-hydroxyestriol (estetrol) in pregnancy serum". Steroids. 27 (6): 785 ...
Toxoid
... tetanus immune globulin (TIG), HyperTet (c)), which has replaced horse serum-type tetanus antitoxin in most of the developed ... "Tetanus Immune Globulin (Human)" (PDF). September 2012. Archived from the original (PDF) on 4 March 2016. Retrieved 2010-05-29 ... in the United States for the development of highly immune persons for the production of human anti-tetanus immune globulin ( ...
Pharmacology of bicalutamide
Serum FSH levels exhibited a similar plateau after 35 days, with maximum titers 70-360% over control. The range in serum ... It has negligible affinity for SHBG and no affinity for corticosteroid-binding globulin. The tissue distribution of ... With an oral dose of 50 mg/day, bicalutamide attains a peak serum level of 8.9 mg/L (21 μmol/L) 31 hr after a dose at steady ... Increase in serum LH levels ranged from 200-700% during the initial 21 days of clomiphene administration but then plateaued. ...
Steroid hormone
Some examples are sex hormone-binding globulin (SHBG), corticosteroid-binding globulin, and albumin. Most studies say that ... gestrinone Steroid hormones are transported through the blood by being bound to carrier proteins-serum proteins that bind them ... bound to specific carrier proteins such as sex hormone-binding globulin or corticosteroid-binding globulin. Further conversions ... hormones can only affect cells when they are not bound by serum proteins. In order to be active, steroid hormones must free ...
Estradiol cyclooctyl acetate
Effects on serum lipids, proteins, gonadotrophins, estrogens and uterine endometrial morphology". Gynecol. Obstet. Invest. 20 ( ... estradiol orally and has a comparatively reduced impact on liver parameters such as changes in sex hormone-binding globulin ...
Side effects of cyproterone acetate
"Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total ... Serum vitamin B12 monitoring and supplementation (e.g., 100 to 200 μg/day orally) as necessary may be recommended during CPA ... Schiebinger, Rick J.; Chrousos, George P.; Culter, Gordon B.; Loriaux, D. Lynn (1986). "The Effect of Serum Prolactin on Plasma ... 96-96). Bercovich, E., Cigno, M., & Soli, M. (1983, January). Serum prolactin levels induced by cyproterone acetate therapy in ...
Ketoconazole
Gal M, Orly J, Barr I, Algur N, Boldes R, Diamant YZ (May 1994). "Low dose ketoconazole attenuates serum androgen levels in ... Ketoconazole has been found to displace dihydrotestosterone and estradiol from sex hormone-binding globulin in vitro, but this ...
Meningococcal disease
Ross SC, Berberich HM, Densen P (December 1985). "Natural serum bactericidal activity against Neisseria meningitidis isolates ... use of vaccines and immune globulins for persons with altered immunocompetence". MMWR Recomm Rep. 42 (RR-4): 1-18. PMID 8474421 ...
Soybean
... soy protein-like globulin storage proteins; or only one of these globulin proteins. S denotes Svedberg, sedimentation ... December 2010). "Soy Protein Reduces Serum Cholesterol by Both Intrinsic and Food Displacement Mechanisms". The Journal of ... Peanuts, for instance, contain 20% 2S albumin but only 6% 7S globulin and 74% 11S. It is the high 2S albumin and low 7S ... Cocoa, for example, contains the 7S globulin, which contributes to cocoa/chocolate taste and aroma, whereas coffee beans ( ...
List of OMIM disorder codes
... elevated serum; 123320; CAV3 Creutzfeldt-Jakob disease; 123400; PRNP Crigler-Najjar syndrome type I; 218800; UGT1A1 Crigler- ... CNTNAP2 Corticosteroid-binding globulin deficiency; 611489; CBG Cortisone reductase deficiency; 604931; H6PD Cortisone ...
Pharmacokinetics of progesterone
It is bound 80% to albumin, 18% to corticosteroid-binding globulin, and less than 1% to sex hormone-binding globulin, with the ... With intramuscular injection, a dose of 25 mg results in normal luteal phase serum levels of progesterone within 8 hours, and a ... sex hormone-binding globulin, and corticosteroid-binding globulin, and as much as 15 to 35% of total steroid hormone content in ... Steroid hormones including progesterone have been found to be transported by red blood cells in addition to serum carrier ...
Transferrin
In nephrotic syndrome, urinary loss of transferrin, along with other serum proteins such as thyroxine-binding globulin, ... Levels of serum iron and total iron binding capacity (TIBC) are used in conjunction with transferrin to specify any abnormality ... Studies reveal that a transferrin saturation (serum iron concentration ÷ total iron binding capacity) over 60 percent in men ... This finding helps in the early diagnosis of Hereditary hemochromatosis, especially while serum ferritin still remains low. The ...
CSL Limited
Sequirus Commonwealth Serum Laboratories "CSL Behring Acquires Biotech Company Calimmune and its Proprietary Stem Cell Gene ... sub-cutaneous human immune globulin indicated for the treatment of primary immunodeficiency. This product gained FDA approval ... CSL was founded in 1916 as the Commonwealth Serum Laboratories, an Australian government body focused on vaccine manufacture. ... AH Brogan, Committed to Saving Lives: a History of the Commonwealth Serum Laboratories (Melbourne: Hyland House, 1990). Dando ...
Serum sickness
May 2007). "Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and ... Serum sickness is becoming less common over time. Many drugs based on animal serum have been replaced with artificial drugs. ... Serum sickness is usually a result of exposure to antibodies derived from animals. These sera or antitoxins are generally given ... Serum sickness was first characterized by Clemens von Pirquet and Béla Schick in 1906. Hypersensitivity Arthus reaction Serum ...
Coagulation
Factor VII (also known as serum prothrombin conversion accelerator or proconvertin, precipitated by barium sulfate) was ... it was identified in the 1950s and is alternatively called antihemophilic globulin due to its capability to correct hemophilia ...
John Gorman (physician)
"A vial of human serum, an ice box and an illegal flight: how an Australian doctor saved millions of babies' lives". ABC News. ... immune globulin, as treatment. Since its discovery, Gorman's treatment is estimated to have saved millions of lives. "Vaccine ...
Serum globulin electrophoresis: MedlinePlus Medical Encyclopedia
The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. ... The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. ... Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulins include various types of ... Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L) ...
Effectiveness of locally inoculated antirabies serum and gamma-globulin in rabies infection of mice
Secular Decline in Male Testosterone and Sex Hormone Binding Globulin Serum Levels in Danish Population Surveys - Hotze Health ...
Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK...
Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK ... on serum testosterone and sex hormone-binding globulin (SHBG) in men aged 40-69 years. DESIGN:. Cross-sectional analysis of ... Different combinations of these factors varied serum testosterone by ~4 nmol/L, SHBG by ~30 nmol/L and cFT by ~60 pmol/L. ... Median (interquartile range) for serum testosterone was 11.6 (9.4-14.1) nmol/L, SHBG 36.9 (27.9-48.1) nmol/L and cFT 213 (178- ...
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Serum amyloid a levels and alpha 2 and gamma globulins on serum protein electrophoresis in cats exposed to and infected with ... Serum protein profiles and c-reactive protein in natural canine filariasis. Background and Aim: Canine filariasis is caused by ... Serum protein electrophoresis in Dirofilaria immitis naturally infected dogs: latest news and a systematic literature review. ... The aim of this pilot study (therapeutic, prospective and non-controlled) was to evaluate the effect of domperidone on serum... ...
Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile...
Passive Immunization with WNV Immune Globulin. Hamsters inoculated with WNV immune serum (0.5 mL and 0.1 mL) appeared to be ... Immune globulins present in the WNV-immune serum probably inhibited virus replication; consequently, insufficient antigenic ... Hamster serum samples were diluted in phosphate-buffered saline, pH 7.4, containing 10% fresh guinea pig serum. Virus inoculum ... Convalescent-phase sera from some of these animals were used to prepare the WNV immune serum used in the passive immunization ...
Tinea Pedis: Background, Pathophysiology, Epidemiology
Med terms G- med term root list - Medical Terminology - GlobalRPH
IJERPH | Free Full-Text | Increase in Metabolic Syndrome-Related Hospitalizations in Relation to Environmental Sources of...
Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J. Clin. ... High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population. ... with the association being the strongest for the two middle quartiles of serum POP levels. Serum levels of other POP ... Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non- ...
Measles and Mumps Vaccines - Adverse Events Associated with Childhood Vaccines - NCBI Bookshelf
The use of concentrated normal human serum gamma globulin (human immune serum globulin) in the prevention and attenuation of ... Three classes of immune globulin (IgA, IgG, and IgM) are produced and are detectable in the serum and nasal mucus of vaccinated ... SSPE was diagnosed by high measles virus titers in serum and CSF and a high ratio of immunoglobulin G/albumin in serum and CSF ... gamma globulin alone, or killed measles vaccine. Twenty-five of 28 patients who received immune globulin along with measles ...
Prevention of Hepatitis A Through Active or Passive Immunization: Recommendations of the Advisory Committee on Immunization...
Mosley JW, Reisler DM, Brachott D, Roth D, Weiser J. Comparison of two lots of immune serum globulin for prophylaxis of ... Single and booster dose responses to an inactivated hepatitis A virus vaccine: comparison with immune serum globulin ... Immune Globulin) contained errors regarding the , , recommended delay between administration of immune globulin and , , ... Kluge T. Gamma-globulin in the prevention of viral hepatitis: a study on the effect of medium-size doses. Acta Med Scand 1963; ...
WHO EMRO | Hepatitis E in Pakistan | Volume 2, issue 1 | EMHJ volume 2, 1996
Immunoprophylaxis of enterically transmitted non-A, non-B hepatitis with immune serum globulin. Chinese journal of epidemiology ... The serum markers of HAV and HBV were done in all cases, and no case was found to be due to recent infection with these viruses ... Two serum samples have to be taken, one during the acute phase and one after two weeks from onset of the disease. The prior ... Paired sera from two patients were tested by immune electron microscopy (IEM), and these cases of AVH were confirmed to be due ...
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The estrogen component of COCs may raise the serum concentrations of thyroxine-binding globulin, sex hormone-binding globulin, ... Cmax = peak serum concentration, tmax = time to reach peak serum concentration, AUC0-24h = area under serum concentration vs ... EE is extensively bound (,97%) to serum albumin and induces an increase in the serum concentrations of SHBG. ... 5.12 Effect on Binding Globulins 5.13 Monitoring 5.14 Hereditary Angioedema 5.15 Chloasma 6 ADVERSE REACTIONS 6.1 Clinical ...
Protein-Losing Enteropathies - Low Albumin Is Not Always a Bad Prognosis - WSAVA 2015 Congress - VIN
Finally, contrary to what the textbooks say, PLE may be associated with a low, normal or increased serum globulin concentration ... Dogs with lymphangiectasia often show a marked increase in serum albumin concentration within 7-14 days of starting such a diet ... Next, hepatic function testing (e.g., resting and postprandial serum bile acid concentrations) and a urinalysis are requested. ... such an approach is generally ill-advised if the serum albumin concentration is less than 2.0 g/dl. This is true because it may ...
Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis
Some of these antibodies are present in the patients’ serum several years before the onset of clinical disease. Various ... and presence of autoantibodies against several self-structures in the serum and synovial fluid. These autoantibodies ( ... RF has been widely used in the diagnosis of RA since its discovery in 1940 as an antibody directed against serum gamma-globulin ... J. M. Stuart and F. J. Dixon, "Serum transfer of collagen-induced arthritis in mice," The Journal of Experimental Medicine, vol ...
Erectile Dysfunction: Practice Essentials, Background, Anatomy
Rosalyn Sussman Yalow - American Chemical Society
Curewel India : | Economic and Political Weekly
Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate | Clinical Cancer Research | American...
Contribution of dihydrotestosterone to male sexual behaviour | The BMJ
Serum hormone concentrations were determined by commercially available RIA kits (Coat-a-Count, DPC, Los Angeles, for ... for sex hormone binding globulin). The sensitivity of the assays was as follows: testosterone 0.14 nmol/l, oestrone 30.0 pmol/l ... Results: Serum dihydrotestosterone concentration was the only independent hormonal predictor of the frequency of orgasms; an ... Blood samples for the hormone determinations were centrifuged immediately, and serum was frozen at −34°C until determination. ...
Donald Trump Coronavirus Task Force Briefing Transcript March 31: 'Painful' Weeks Ahead | Rev
Patient 1980,1981,1985,1989,1990
DeCS
... which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the ... which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the ... Serum Globulins - Preferred Concept UI. M0019698. Scope note. All blood proteins except albumin ( = SERUM ALBUMIN, which is not ... All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN ( ...
aids-111121083601-phpapp02.pdfHormone-bindingAntirabies serumImmune serum globulinProteinsRabies immune globulinGammaProteinTestosteroneAntithymocyte globulinHepatitisConcentrationsAlbuminAplastic anemiaAcuteAntibodyInfectionLevelsSicknessSolid organ transplantationAntibodiesConcentrationDiagnoseGeneticResultsClinicalPlasmaThyroidIllnessesFluidEvaluateLiquidPatientsAdministrationYearsFormsStudiesProductsForm
Hormone-binding4
- Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK Biobank. (bvsalud.org)
- We evaluated the impact of sociodemographic, lifestyle and medical factors, on serum testosterone and sex hormone-binding globulin (SHBG) in men aged 40-69 years. (bvsalud.org)
- Anavar is not the best choice for building given amount of tension improves tightly bound to a protein called serum hormone-binding globulin (SHBG). (bootb.com)
- DiaSorin is pleased to announce the launch of the new LIAISON® test for the measurement of SHBG (Sex Hormone-Binding Globulin) in human serum and plasma, available worldwide with the exception of the U.S. SGHB, which is produced in the liver, is involved in transport of sex steroids, such as dihydrotestosterone, testosterone and estradiol, in the blood stream. (diasorin.com)
Antirabies serum1
- [1,2] Similarly, beneficial results were later reported from the U.S.S.R. [3] Studies coordinated by WHO (World Health Organization) helped determine the optimal conditions under which antirabies serum of equine origin and rabies vaccine can be used in man. (nih.gov)
Immune serum globulin4
- This double blind, randomized, controlled trial was designed to test the efficacy of hepatitis B immune serum globulin (HBIG) for the prevention or modification of post-transfusion hepatitis (PTH). (nih.gov)
- An earlier randomized, double-blind clinical trial had been conducted in 11 Veterans Administration (VA) hospitals between 1969 and 1973 to evaluate the efficacy of immune serum globulin (ISG) in comparison to placebo as prophylaxis against post-transfusion hepatitis. (nih.gov)
- Immune serum globulin (given for hepatitis exposure) and tetanus antitoxin are examples of passive immunization. (nih.gov)
- Treatment may include administration of immune serum globulin, antibiotics for infections, and anti-inflammatory drugs, if needed. (nih.gov)
Proteins7
- The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. (medlineplus.gov)
- This test is done to look at globulin proteins in the blood. (medlineplus.gov)
- Most of the time, these hormones circulate in the bloodstream attached to thyroxine-binding globulin and similar proteins. (nih.gov)
- Electrophoresis of serum proteins showed increased levels of gamma globulins. (cdc.gov)
- Within plasma and serum, there are globulin and albumin proteins. (edinst.com)
- All blood proteins except albumin ( = SERUM ALBUMIN , which is not a globulin) and FIBRINOGEN (which is not in the serum). (nih.gov)
- Upon discovering that globulins (serum proteins) bound radioactive insulin in the blood of insulin-treated diabetics, they concluded that insulin injections immunized patients so that they develop insulin-binding antibodies, which keeps the insulin molecules in the bloodstream. (acs.org)
Rabies immune globulin2
- Hyper RAB S/D is then incubated in the final container for 21-28 days at 20-27°C. The product is standardized against the U.S. Standard Rabies Immune Globulin to contain an average potency value of 150 IU/mL. (nih.gov)
- Preparation of rabies immune globulin of human origin with adequate potency was reported by Cabasso et al. (nih.gov)
Gamma8
- Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. (medlineplus.gov)
- Gamma globulins include various types of antibodies such as immunoglobulins (Ig) M, G, and A. (medlineplus.gov)
- Exclusion criteria included the likelihood of repeated transfusions in the next six months, transfusions or gamma globulin products within the previous six months, serious illnesses limiting survival, previous participation in this trial, and unwillingness to sign the informed consent. (nih.gov)
- Serum amyloid a levels and alpha 2 and gamma globulins on serum protein electrophoresis in cats exposed to and infected with Leishmania infantum . (cabi.org)
- Gamma globulin - A class of serum globulins produced by lymphocytes and plasma cells of the immune system. (globalrph.com)
- The initial method of prevention depended on postexposure prophylaxis with immune gamma globulin (Stokes et al. (nih.gov)
- It required vigilance with respect to exposure and almost immediate action, because if gamma globulin was given more than 4 days after the exposure, it was no longer effective at preventing disease, although it did attenuate it. (nih.gov)
- and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (nih.gov)
Protein5
- Thyroxine-binding globulin is a protein that carries hormones made or used by the thyroid gland, which is a butterfly-shaped tissue in the lower neck. (nih.gov)
- Researchers have identified two forms of inherited thyroxine-binding globulin deficiency: the complete form (TBG-CD), which results in a total loss of thyroxine-binding globulin, and the partial form (TBG-PD), which reduces the amount of this protein or alters its structure. (nih.gov)
- Serum protein electrophoresis in Dirofilaria immitis naturally infected dogs: latest news and a systematic literature review. (cabi.org)
- Contains 55 grams globulin protein, made with easily absorbed bovine serum and high quality colostrum. (valleyvet.com)
- A type of serum protein (globulin) synthesized by white blood cells of the lymphoid type in response to an antigenic (foreign substance) stimulus. (digitalnaturopath.com)
Testosterone5
- Serum testosterone concentrations are affected by factors unrelated to hypothalamo-pituitary-testicular axis pathology . (bvsalud.org)
- MEASUREMENTS We analysed associations of different factors with serum testosterone and SHBG ( immunoassays ) and calculated free testosterone (cFT), using smoothed centile plots, linear mixed models and effect size estimates. (bvsalud.org)
- Median (interquartile range) for serum testosterone was 11.6 (9.4-14.1) nmol/L, SHBG 36.9 (27.9-48.1) nmol/L and cFT 213 (178-255) pmol/L. Age and BMI were inversely associated with testosterone and cFT, while SHBG was associated with age and inversely with BMI (all P (bvsalud.org)
- Different combinations of these factors varied serum testosterone by ~4 nmol/L, SHBG by ~30 nmol/L and cFT by ~60 pmol/L. (bvsalud.org)
- NICE MS Guideline also recommends that steroids belong to the most effective and concomitant medications can also affect serum testosterone levels. (bootb.com)
Antithymocyte globulin5
- Thymoglobulin (Genzyme, Cambridge, MA) is an antithymocyte globulin preparation used for induction immunosuppression therapy in solid organ transplantation. (nih.gov)
- Early treatment of serum sickness with steroids or plasmapheresis is highly effective and can reduce unnecessary morbidity from this unusual sequela of induction immunosuppression with antithymocyte globulin. (nih.gov)
- Serum sickness and severe acute renal failure after rabbit antithymocyte globulin treatment in aplastic anemia: a case report. (nih.gov)
- Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia. (nih.gov)
- Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. (nih.gov)
Hepatitis5
- Indeed, administration of ATG for acute rejection after liver transplantation is usually followed by a prompt decrease in serum enzymes and jaundice, and administration of ATG for aplastic anemia with hepatitis or hepatitis from check point inhibitors such as ipilumumab commonly results in a prompt improvement in the jaundice and serum enzyme elevations. (nih.gov)
- This report provides recommendations for use of the newly licensed hepatitis A vaccines (HAVRIX, manufactured by SmithKline Beecham Biologicals, and VAQTA, manufactured by Merck & Company, Inc.) in persons greater than or equal to 2 years of age and updates previous recommendations for use of immune globulin (IG) for protection against hepatitis A (superseding MMWR 1990;39{No. RR-2}:1-5). (cdc.gov)
- Until recently, the primary methods used for preventing hepatitis A have been hygienic measures and passive immunization with immune globulin (IG) to provide short-term preexposure or postexposure protection (1). (cdc.gov)
- Previously, there were only two broad categories of AVH recognized: infectious hepatitis and serum hepatitis. (who.int)
- Contrary to conventional belief, it was later discovered that a virus other than hepatitis A virus (HAV) was the cause of such epidemics, as the stored sera collected from these outbreaks did not react to the newly developed anti-Hep A IgM (immunoglobulin M) in 1970s. (who.int)
Concentrations2
- Next, hepatic function testing (e.g., resting and postprandial serum bile acid concentrations) and a urinalysis are requested. (vin.com)
- In one study of OCD patients, 20% had abnormally low serum vitamin B12 concentrations compared to the two control groups. (digitalnaturopath.com)
Albumin4
- Raman spectrum of human serum albumin with band assignments. (edinst.com)
- CUREWFL, (INDIA), which started with production of human globulin and human serum albumin in powder and solution forms, proposes to expand and diversify its lines of production. (epw.in)
- Although therapeutic trials can be chosen in place of classic diagnostic tests in many of the more common alimentary tract diseases (e.g., dietary allergy, dietary intolerance, antibiotic-responsive enteropathy, parasites), such an approach is generally ill-advised if the serum albumin concentration is less than 2.0 g/dl. (vin.com)
- This is true because it may be necessary to perform an antibiotic and/or dietary therapeutic trial for 3-6 weeks in order to ascertain if it is being effective, and a patient with severe PLE can become markedly worse in that time, especially if the serum albumin concentration is falling rapidly. (vin.com)
Aplastic anemia1
- In patients with aplastic anemia given ATG, transient serum enzyme elevations arising a few days after the infusions have been reported to occur in up to one-third of patients. (nih.gov)
Acute2
- ATG has been linked to acute elevations in serum enzyme elevations shortly following infusions, but has not been linked to cases of clinically apparent liver injury. (nih.gov)
- Because ATG is made from animal serum, it can induce serious immune mediated reactions such as acute infusion reactions, anaphylaxis, serum sickness and cytokine release syndrome. (nih.gov)
Antibody1
- [8,9] These studies determined that a human globulin dose of 20 IU/kg of rabies antibody, given simultaneously with the first DEV dose, resulted in amply detectable levels of passive rabies antibody 24 hours after injection in all recipients. (nih.gov)
Infection2
- AHS, ESDA, and ESCCAP), a correct diagnosis of Dirofilaria immitis infection should include the detection of circulating microfilariae in the whole blood and the adult antigens in serum. (cabi.org)
- An effort to allow the infection to take place, but in an attenuated form, by injecting less immune globulin was usually successful. (nih.gov)
Levels2
- Serum alkaline phosphatase and bilirubin levels rise minimally, if at all. (nih.gov)
- In contrast, serum folate levels were unrelated to age of onset of the disease. (digitalnaturopath.com)
Sickness2
Solid organ transplantation1
- When given as a part of induction therapy for solid organ transplantation, ATG has not been linked to serum enzyme elevations or hepatotoxicity, but it is given with other medications and in preparation for major surgery so that some degree of liver injury might well be missed. (nih.gov)
Antibodies1
- Some of these antibodies are present in the patients' serum several years before the onset of clinical disease. (hindawi.com)
Concentration1
- Finally, contrary to what the textbooks say, PLE may be associated with a low, normal or increased serum globulin concentration. (vin.com)
Diagnose2
- Identifying the types of globulins can help diagnose certain medical problems. (medlineplus.gov)
- Therefore, it is important to diagnose inherited thyroxine-binding globulin deficiency to avoid unnecessary treatments. (nih.gov)
Genetic1
- Inherited thyroxine-binding globulin deficiency is a genetic condition that typically does not cause any health problems. (nih.gov)
Results1
- Inherited thyroxine-binding globulin deficiency results from mutations in the SERPINA7 gene. (nih.gov)
Clinical1
- [8] In carefully controlled clinical studies, this globulin was used in conjunction with rabies vaccine of duck-embryo origin (DEV). (nih.gov)
Plasma1
- The best way to analyse blood via Raman spectroscopy is by analysing the plasma or the serum. (edinst.com)
Thyroid2
- If there is a shortage (deficiency) of thyroxine-binding globulin, the amount of circulating thyroid hormones is reduced. (nih.gov)
- Although inherited thyroxine-binding globulin deficiency does not cause any health problems, it can be mistaken for more serious thyroid disorders (such as hypothyroidism). (nih.gov)
Illnesses1
- Non-inherited thyroxine-binding globulin deficiency can occur with a variety of illnesses and is a side effect of some medications. (nih.gov)
Fluid2
- This fluid is called serum. (medlineplus.gov)
- Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self-structures in the serum and synovial fluid. (hindawi.com)
Evaluate1
- The aim of this pilot study (therapeutic, prospective and non-controlled) was to evaluate the effect of domperidone on serum. (cabi.org)
Liquid1
- Serum is the liquid that remains after the blood has clotted, to isolate serum a blood sample is allowed to clot and then centrifuged with the remaining liquid supernatant the serum. (edinst.com)
Patients1
- In the 1940s, presence of RF in the serum of RA patients was identified and consequently used as the "gold standard" for the diagnosis [ 5 ]. (hindawi.com)
Administration1
- Administration of the vaccine with immune globulin of the proper titer attenuated the reaction without interfering with the induction of permanent immunity. (nih.gov)
Years1
- Introduction: The study of early markers to detect kidney malfunction has increased in recent years since serum markers, such as creatinine increase when there is a 75% loss of renal mass. (cabi.org)
Forms1
- Researchers have also described non-inherited forms of thyroxine-binding globulin deficiency, which are more common than the inherited form. (nih.gov)
Studies1
- [4-7] These studies showed that serum can interfere to a variable extent with the active immunity induced by the vaccine, but could be minimized by booster doses of vaccine after the end of the usual dosage series. (nih.gov)
Products1
- negative blood products for transfusion Using CMV - immune globulin in certain people Preventing HIV /AIDS avoids certain other diseases, including CMV , that can occur in people who have a weakened immune system. (nih.gov)
Form1
- The complete form of inherited thyroxine-binding globulin deficiency, TBG-CD, affects about 1 in 15,000 newborns worldwide. (nih.gov)
