AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
Self AdministrationAdministration, OralAdministration, SublingualEncyclopedias as TopicNitroglycerinLipSphenoid BoneNasal SeptumAngina PectorisCosts and Cost AnalysisResearchHealth Care CostsDecision MakingUnited StatesConservation of Natural ResourcesCost-Benefit AnalysisDirectories as TopicSoftwareUser-Computer InterfaceAlgorithmsProgramming LanguagesSoftware DesignComputational BiologyElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetGolfPensionsHealth ManpowerDelegation, ProfessionalSalaries and Fringe BenefitsPersonnel ManagementFederal Government
Self Administration: Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Administration, Sublingual: Administration of a soluble dosage form by placement under the tongue.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Lip: Either of the two fleshy, full-blooded margins of the mouth.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Nasal Septum: The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Costs and Cost Analysis: Absolute, comparative, or differential costs pertaining to services, institutions, resources, etc., or the analysis and study of these costs.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Health Care Costs: The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.Decision Making: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.United StatesConservation of Natural Resources: The protection, preservation, restoration, and rational use of all resources in the total environment.Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Software: Sequential operating programs and data which instruct the functioning of a digital computer.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Programming Languages: Specific languages used to prepare computer programs.Software Design: Specifications and instructions applied to the software.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Golf: A game whose object is to sink a ball into each of 9 or 18 successive holes on a golf course using as few strokes as possible.Pensions: Fixed sums paid regularly to individuals.Health Manpower: The availability of HEALTH PERSONNEL. It includes the demand and recruitment of both professional and allied health personnel, their present and future supply and distribution, and their assignment and utilization.Delegation, Professional: The process of assigning duties to a subordinate with lesser qualifications.Salaries and Fringe Benefits: The remuneration paid or benefits granted to an employee.Personnel Management: Planning, organizing, and administering all activities related to personnel.Federal Government: The level of governmental organization and function at the national or country-wide level.

Behavioral, toxic, and neurochemical effects of sydnocarb, a novel psychomotor stimulant: comparisons with methamphetamine. (1/2040)

Sydnocarb (3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine) is a psychostimulant in clinical practice in Russia as a primary and adjunct therapy for a host of psychiatric disorders, including schizophrenia and depression. It has been described as a stimulant with an addiction liability and toxicity less than that of amphetamines. The present study undertook to evaluate the psychomotor stimulant effects of sydnocarb in comparison to those of methamphetamine. Sydnocarb increased locomotor activity of mice with reduced potency (approximately 10-fold) and efficacy compared with methamphetamine. Sydnocarb blocked the locomotor depressant effects of haloperidol at doses that were inactive when given alone. The locomotor stimulant effects of both methamphetamine and sydnocarb were dose-dependently blocked by the dopamine D1 and D2 antagonists SCH 39166 and spiperone, respectively; blockade generally occurred at doses of the antagonists that did not depress locomotor activity when given alone. In mice trained to discriminate methamphetamine from saline, sydnocarb fully substituted for methamphetamine with a 9-fold lower potency. When substituted for methamphetamine under self-administration experiments in rats, 10-fold higher concentrations of sydnocarb maintained responding by its i.v. presentation. Sydnocarb engendered stereotypy in high doses with approximately a 2-fold lower potency than methamphetamine. However, sydnocarb was much less efficacious than methamphetamine in inducing stereotyped behavior. Both sydnocarb and methamphetamine increased dialysate levels of dopamine in mouse striatum; however, the potency and efficacy of sydnocarb was less than methamphetamine. The convulsive effects of cocaine were significantly enhanced by the coadministration of nontoxic doses of methamphetamine but not of sydnocarb. Taken together, the present findings indicate that sydnocarb has psychomotor stimulant effects that are shared by methamphetamine while demonstrating a reduced behavioral toxicity.  (+info)

Ethanol as a hypnotic in insomniacs: self administration and effects on sleep and mood. (2/2040)

The purpose of this study was to assess the effects of low ethanol doses on sleep and mood and to assess its reinforcing effects used as a hypnotic. Twenty healthy adults, aged 21-45 yrs, all moderate social drinkers, were studied: eleven subjects had insomnia and nine were normal sleepers, as documented by clinical polysomnography. On two sampling nights each, ethanol (0.5 g/kg) or placebo was administered before sleep in color-coded cups presented in three doses (0.2, 0.2, and 0.1 g/kg) separated by 15 min. On three subsequent nights subjects chose their preferred presleep beverage (0.2 g/kg ethanol or placebo) based on cup color and were given an opportunity for 3 additional refills (0.2 g/kg each) of the chosen beverage at 15 min intervals, yielding a total possible dose of 0.8 g/kg. Insomniacs chose ethanol 67% of nights and normals 22%. Insomniacs chose significantly more ethanol refills than normals for an average nightly dose of 0.45 g/kg and normals took significantly more placebo refills. On the sampling nights 0.5 g/kg ethanol reduced REM sleep for both groups for the 8-hr sleep period and in insomniacs increased stage 3-4 sleep and reduced stage 1 sleep during the first half of the night to the level seen in the normals. Other sleep variables were not altered in either group or halves of the night. Presleep improvements in the Profile of Mood States tension and concentration factors were also associated with ethanol administration. Thus, acutely, both sleep and mood effects appear to be associated with the reinforcing effects of ethanol as a hypnotic for insomniacs.  (+info)

Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. (3/2040)

Clinical observations suggest that stimuli associated with the availability or consumption of ethanol can evoke subjective feelings of craving and trigger episodes of relapse in abstinent alcoholics. To study the motivational significance of alcohol-related environmental cues experimentally, the effects of discriminative stimuli previously predictive of alcohol availability on the reinstatement of ethanol-seeking behavior were examined. Wistar rats were trained to lever-press for 10% (w/v) ethanol or water in the presence of distinct auditory cues. The rats were then subjected to an extinction phase where lever presses had no scheduled consequences. After extinction, the animals were exposed to the respective auditory cues without the availability of ethanol or water. Neither the ethanol (SA+) nor water-associated (SA-) auditory cue increased responding over extinction levels. In contrast, subsequent presentation of an olfactory cue associated with ethanol (SO+), but not a water-associated (SO-) cue significantly reinstated lever pressing behavior in the absence of the primary reinforcer. Moreover, responding elicited by the concurrent presentation of the SO+ and SA+ was selectively attenuated by the opiate antagonist naltrexone (0.25 mg/kg; s.c.). The results suggest that ethanol-associated cues can reinstate extinguished ethanol-seeking behavior in rats, but that the efficacy of these stimuli may be modality-specific. In addition, the present procedures may be useful for studying neurobiological mechanisms of alcohol-seeking behavior and relapse.  (+info)

An evaluation of increasing doses of ranitidine for treatment of heartburn. (4/2040)

BACKGROUND: This was a randomized, double-blind, placebo-controlled, multicentre, parallel group, dose-ranging trial of ranitidine tablets for relief of episodic heartburn. Adult out-patients who reported heartburn relieved by antacids at least seven times per week were eligible. METHODS: Patients who successfully completed a 1-week single-blind placebo run-in phase and who did not achieve adequate relief in more than 50% of heartburn episodes were randomized to a 1-week, double-blind treatment phase during which they received ranitidine doses of 25, 75 or 125 mg, or placebo. RESULTS: Of 577 patients randomized, 566 had at least one evaluable heartburn episode and were included in the intention-to-treat analysis. All three ranitidine doses were statistically significantly superior to placebo in providing overall episodic heartburn relief for the first episode (P < 0.002), last episode (P+info)

Dopamine fluctuations in the nucleus accumbens during maintenance, extinction, and reinstatement of intravenous D-amphetamine self-administration. (5/2040)

Moment-to-moment fluctuations of nucleus accumbens dopamine (DA) were determined in rats self-administering or passively receiving "yoked" intravenous infusions of D-amphetamine. The initial lever presses of each session caused elevations in DA concentration, usually to an initial peak that was not maintained throughout the rest of the session. As the initial ("loading") injections were metabolized, DA levels dropped toward baseline but were sustained at elevated plateaus by subsequent lever pressing that was spaced throughout the remainder of the 3 hr sessions. During this period, DA levels fluctuated phasically, time-locked to the cycle of periodic lever pressing. Consistent with the known pharmacological actions and dynamics of amphetamine, peak DA elevations were seen approximately 10-15 min after each injection, and the mean DA level was at a low point in the phasic cycle at the time of each new lever press. During extinction periods when saline was substituted for amphetamine, DA levels dropped steadily toward baseline levels despite a dramatic increase in (now-unrewarded) lever pressing. Noncontingent injections during extinction reinstated lever-pressing behavior and increased nucleus accumbens DA concentrations. These data are consistent with the hypothesis that under the conditions of this experiment-during periods of amphetamine intoxication in well-trained animals-the timing of amphetamine self-administration comes primarily under the control of extracellular DA concentrations. The probability of lever pressing during the maintenance phase is highest when DA concentrations fall near a characteristic trigger point, a trigger point that is significantly elevated above baseline, and falls as DA concentrations fall below or increase above that trigger point.  (+info)

Effects of contingent and non-contingent cocaine on drug-seeking behavior measured using a second-order schedule of cocaine reinforcement in rats. (6/2040)

Rats were trained to respond with intravenous cocaine as the reinforcer under a fixed interval 15-min schedule, during which conditioned stimuli paired with cocaine were presented contingent on completion of a fixed ratio of 10 responses (i.e., second-order schedule of reinforcement). The effects of contingent and noncontingent cocaine were investigated. The results show that pretreatment with noncontingent (i.e., experimenter-administered) cocaine led to a satiation-like effect that was reflected in decreased numbers of responses and a tendency for an increased latency to initiate responding when the doses of cocaine administered were similar to or higher than the training/maintenance dose of cocaine. By contrast, noncontingent administration of cocaine doses lower than the training/maintenance dose, and response-contingent cocaine administration, led to increased drug-seeking behavior, as reflected in increased numbers of responses. The present data indicate that at least two factors determine whether administration of cocaine would lead to drug-seeking behavior: whether the cocaine administration is contingent or noncontingent, and the relative magnitude of the cocaine dose administered in relation to the training/maintenance dose of cocaine.  (+info)

Effects of self-administered cocaine on plasma adrenocorticotropic hormone and cortisol in male rhesus monkeys. (7/2040)

This study was designed to examine the effects of self-administered cocaine on hypothalamic-pituitary-adrenal (HPA) axis activity in rhesus monkeys. Initially, basal release of cortisol and adrenocorticotropic hormone (ACTH) was measured in singly housed male and female monkeys (n = 9) over a 24-h period using plasma samples obtained from indwelling venous catheters. Basal cortisol and ACTH levels in both male and female rhesus monkeys demonstrated a circadian pattern of release, with peak levels for cortisol (19.60 +/- 2.16 microgram/dl) and ACTH (19.63 +/- 2.56 pg/ml) measured at 6:00 AM. The nadir for ACTH (6.27 +/- 0.62 pg/ml) occurred at 6:00 PM, preceding the cortisol nadir (5.55 +/- 1.21 microgram/dl) at 9:00 PM. The reinforcing effects of saline, 0.01, 0.03, 0.1, and 0.3 mg/kg/injection cocaine were then evaluated using a fixed-ratio 30, time-out 10-min schedule of reinforcement in seven male monkeys. Blood was sampled before, during, and after self-administration sessions. Self-administration of cocaine produced dose-dependent increases in cortisol and ACTH. One dose of cocaine (0.03 mg/kg/injection), although reliably self-administered, did not produce a significant increase in HPA axis activity. These results indicate that although cocaine dose-dependently increases HPA axis activity, the HPA effect is more likely a consequence of overall cocaine intake than it is an indicator of cocaine doses that are sufficient to maintain self-administration behavior.  (+info)

The cost effectiveness of patient-applied versus provider-administered intervention strategies for the treatment of external genital warts. (8/2040)

OBJECTIVE: External genital warts are one of the fastest growing sexually transmitted diseases in the United States today. Two forms of therapy are available: provider-administered and patient-applied. In the most widely used provider-administered ablative therapies, sustained clearance rates range from 18.5% to 40.1%. With nonablative, patient-applied therapies, which are typically more acceptable to patients, sustained clearance rates range from 19.6% with podofilox gel to 44.0% with imiquimod cream. The purpose of this study, given the range of therapies available, their cost differences, and clinical trial-reported differences in rates of sustained clearance, is to determine which therapy modalities, from the providers' perspective, are the most cost effective and which are likely to be the most acceptable to the patient population. STUDY DESIGN: We consider the cost effectiveness of the two patient-applied therapies as first-line therapy followed by provider-administered ablative treatment as second-line therapy. A decision-analytic model framework is developed, with data drawn both from clinical trials and from previously published studies. RESULTS: When considering a two-stage therapy model, with an average sustained clearance rate of 30% assumed for provider-administered ablative therapies, estimated costs per sustained cleared patient are $1265 for patients initially treated with imiquimod and $1304 for patients initially treated with podofilox gel. CONCLUSIONS: Initial treatment with imiquimod is the preferred intervention option as it yields a 39% greater sustained clearance rate than podofilox gel while being 3% less costly per successful outcome.  (+info)

Once is too much: Conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats<...Once is too much: Conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats<...
TY - JOUR. T1 - Once is too much. T2 - Conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats. AU - Colechio, Elizabeth M.. AU - Imperio, Caesar G.. AU - Grigson, Patricia S.. PY - 2014/4/1. Y1 - 2014/4/1. N2 - Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocainepaired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.. AB - Rats emit aversive taste ...
Blockade of the Serotonin 5-HT <sub>2A</sub> Receptor Suppresses Cue-Evoked Reinstatement of Cocaine-Seeking Behavior in a Rat...Blockade of the Serotonin 5-HT <sub>2A</sub> Receptor Suppresses Cue-Evoked Reinstatement of Cocaine-Seeking Behavior in a Rat...
TY - JOUR. T1 - Blockade of the Serotonin 5-HT 2A Receptor Suppresses Cue-Evoked Reinstatement of Cocaine-Seeking Behavior in a Rat Self-Administration Model. AU - Dhonnchadha, B. Á Nic. AU - Fox, R. G.. AU - Stutz, S. J.. AU - Rice, K. C.. AU - Cunningham, Kathryn. PY - 2009/4. Y1 - 2009/4. N2 - The serotonin 5-HT 2A receptor (5-HT 2AR) may play a role in reinstatement of drug-seeking. This study investigated the ability of a selective 5-HT 2AR antagonist to suppress reinstatement evoked by exposure to cues conditioned to cocaine self-administration. Cocaine self-administration (0.75 mg/kg/0.1 mL/6 s infusion; FR 4) was trained in naïve, free-fed rats to allow interpretation of results independent from changes related to food deprivation stress. Pretreatment with the selective 5-HT 2AR antagonist M100907 (volinanserin) failed to reduce rates of operant responding for cocaine infusions. On the other hand, M100907 (0.001-0.8 mg/kg ip) significantly suppressed the cue-induced reinstatement of ...
Schedule-induced oral self administration of etonitazene | MetaSchedule-induced oral self administration of etonitazene | Meta
Rats were induced to drink either a saline-etonitazene solution or a saline solution with a schedule-induced polydipsia paradigm. When water was freely available, the rats continued to drink the saline solution or the saline-etonitazene solution, rather than the water. When the locations of the solutions were switched, the rats that were drinking saline switched to water (drank at the usual location), but the rats that were drinking saline-etonitazene continued to drink the saline-etonitazene solution (drank from the bottle at the other location). Naloxone administration temporarily eliminated the drinking of saline-etonitazene solution, but not that of saline solution. ...
Roches Xolair sBLA for Self Administration Accepted by FDARoche's Xolair sBLA for Self Administration Accepted by FDA
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Plus itPlus it
Using an intravenous drug self-administration model in squirrel monkeys, we found that 2-AG, like THC, cocaine, and other abused drugs, was an effective reinforcer of drug-taking behavior. 2-AG was self-administered by monkeys that had a cannabinoid self-administration history (anandamide monkeys), as well as by monkeys with no history of cannabinoid self-administration (nicotine monkeys). The fact that 2-AG maintained drug-taking behavior in monkeys without a cannabinoid self-administration history suggests that the reinforcing effects of 2-AG were not dependent on prior self-administration of a particular class of drugs. Rates of responding maintained by 2-AG injections were comparable to those maintained under the same conditions by THC, anandamide, methanandamide (a metabolism-resistant analog of anandamide), or cocaine injections in our previous studies (Tanda et al., 2000; Justinova et al., 2003, 2005, 2008).. Although the rates of responding maintained by 2-AG injections were comparable ...
FlorenceFlorence
Cocaine self-administration studies in animals such as mice and rats are helping to clarify the mechanisms and controls of cocaine reward and abuse. Self-administration studies are commonly done in rats using a catheter which is placed into a vein or directly into the brain. Researchers who choose to study the genetics of addiction and self-administration find mice are considerably more useful than rats. This is because their entire genome is sequenced and because we have the ability to mutate or knock out specific genes and then determine the changes in the mice without functional use of these genes. The problem with trying to do cocaine experiments on mice is that due to their small size, it is difficult to properly place and maintain the catheters.. Animals normally respond more severely to repeated doses of cocaine, indicating they are sensitized to subsequent doses of the same concentration. Sensitization can be measured by an increase in repeated behaviors, referred to as stereotypies, ...
NIDA - Directors Report - February, 2010NIDA - Director's Report - February, 2010
Cues present during cocaine self-administration become associated with the drug and if encountered during abstinence, increase the probability of relapse. However, despite much research on human relapse, including the use of animal behavioral models, the way in which relapse-inducing cues are interpreted by the user has remained elusive. Recent theories propose that, after long experience with self administration, drug taking shifts from goal-directed to a habit-like behavior, and therefore cues induce relapse automatically, thus bypassing information processing related to the consequences of relapse. But an alternative hypothesis is that relapse-inducing cues produce an expectation of the drugs consequences, triggering a goal-directed relapse. In animal behavioral experiments, a common procedure used to discriminate between habit and goal-directed responding is reward devaluation: if responding occurs despite devaluation, then the response is considered a habit, or automatic behavior; whereas, ...
Ethanol Self-Administration Procedures | iniastress.orgEthanol Self-Administration Procedures | iniastress.org
Home-Cage Limited Access Drinking Paradigm. The following is a description of general procedures used for measuring voluntary EtOH self- administration in the home cage of mice under limited access conditions. Adult C57BL/6J mice are individually housed in pans with wood-chip bedding under a modified 12 hour light-dark cycle (lights on at 0300 hr). The mice are allowed to acclimate to this housing environment for a minimum of one week prior to the start of the study. Mice have free access to food (rodent lab chow) throughout the study. The animals are weighed once per week, at which time the pans are changed. Water bottles are changed as needed (usually twice per week). Mice are not food or water deprived throughout the study.. Using a modified sucrose-fading technique (Samson, 1986), mice are given daily access to EtOH for 2 hr in the home cage, beginning at 0.5 hr prior to the start of the dark cycle (1430 hr). Standard water bottles are removed and replaced with 15 ml bottles containing ...
Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors | BMC Neuroscience |...Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors | BMC Neuroscience |...
Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, which localizes to post-synaptic densities at glutamatergic synapses, interacts directly with the GluN2B subunit of the N-methyl-d-aspartate (NMDA; GluN) receptor. Consistent with these observations, Kal7 plays an essential role in NMDA receptor dependent long term potentiation and depression, and glutamatergic transmission plays a key role in the response to chronic cocaine. A number of genetic studies have implicated altered Kalirin expression in schizophrenia and other disorders such as Alzheimers Disease. A comparison of the effects of experimenter-administered cocaine on mice lacking all Kalirin isoforms to its effects on mice lacking only Kalirin-7 identified Kal7 as the key isoform whose deletion produces exaggerated locomotor responses to cocaine. Pretreatment of Kal7KO mice with a low
Effect of nicotine self-administration on endocannabinoids &related lipids - Matthew BuczynskiEffect of nicotine self-administration on endocannabinoids &related lipids - Matthew Buczynski
The use of tobacco products is one of leading causes of preventable death worldwide. The psychoactive effects of tobacco have been attributed primarily to its c...
Plus itPlus it
As in previous studies using this and other progressive ratio schedules (Stafford et al., 1998; Wilcox et al., 2000), cocaine functioned as a positive reinforcer and responding increased with dose to an asymptote. (+)-CPCA also functioned as a positive reinforcer under the present progressive ratio schedule, confirming and extending previous self-administration results with this compound in monkeys maintained under a fixed ratio schedule (A. Kozikowski, personal communication). Responding maintained by (+)-CPCA increased with dose then decreased at the highest dose tested. Although only tested in one monkey, it is likely that cocaine-maintained responding would have decreased again had doses of 1.0 mg/kg/injection or higher been tested. In all but one monkey, cocaine was approximately 4-fold more potent than (+)-CPCA as a reinforcer. Maximum levels of responding were higher for cocaine than for (+)-CPCA. Doubling the TO after an injection from 30 to 60 min failed to increase cocaine or ...
Evaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model | RTIEvaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model | RTI
Because Delta9-tetrahydrocannabinol (THC) has been a false negative in rat intravenous self-administration procedures, the evaluation of the abuse potential of candidate cannabinoid medications has proved difficult. One lab group has successfully trained self-administration of the aminoalkylindole WIN55,212-2 in rats; however, their results have not been independently replicated. The purpose of this study was to extend their model by using a within-subjects design, with the goal of establishing a robust method suitable for substitution testing of other cannabinoids.
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor...Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor...
Food maintained responding in mice. Mice were placed in the operant chambers for up to 3 hr/d, 5-7 d per week. Mice were first acclimated to the food that was subsequently used to reinforce operant responding. Mice were deprived of food for 20 hr, which resulted in a mean reduction in body weight of ∼5%. Mice were then placed in test chambers for 2 hr with the fan and house light activated and with a small cup containing 5 ml of vanilla-flavored Ensure (a nutritional supplement, hereafter referred to as "liquid food"; Abbott Laboratories, Columbus, OH). After the acclimation session, mice were given 3 gm each of mouse chow in their home cage. This procedure was repeated until a minimum of 1.5 ml of liquid food was consumed during a 2 hr acclimation session (typically within one or two sessions). Thereafter, mouse chow was available ad libitumin the home cage, and the small cup was removed from the test chamber.. During subsequent 2 hr sessions, liquid food was available under a fixed ratio ...
The Catholic Message Board • View topic - Ashes: Self-administration?The Catholic Message Board • View topic - Ashes: Self-administration?
He said that if he were pastor of a church, in addition to a number of Ash Wednesday services, he would leave the ashes available for self-administration. There was no mention of documental permission for that practice, but the justification he gave was that the ashes are a sacramental (not a sacrament) and like holy water could be self-administered even by a layperson ...
Pyrigesic 1000 MG Infusion - Uses, side effects, substitutes, composition & more | PractoPyrigesic 1000 MG Infusion - Uses, side effects, substitutes, composition & more | Practo
Pyrigesic 1000 MG Infusion is used for fever, headache, muscle pain etc. Know Pyrigesic 1000 MG Infusion uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
Slatin 50 MG Infusion - Uses, side effects, substitutes, composition & more | PractoSlatin 50 MG Infusion - Uses, side effects, substitutes, composition & more | Practo
Slatin 50 MG Infusion is used for testicular cancer, ovarian cancer, bladder cancer etc. Know Slatin 50 MG Infusion uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5 ...Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5 ...
Fig. 1 Prior alcohol use enhances persistence, motivation, and compulsivity for cocaine self-administration.. (A) Drug treatment paradigm to study alcohol and cocaine coadministration. Access to voluntary alcohol (10% alcohol, 2 hours per day) and voluntary cocaine (self-administration, 0.8 mg/kg per injection) was restricted to 3 p.m. to 5 p.m. and 11 a.m. to 2 p.m., respectively, to avoid metabolic interaction between the two drugs. (B) Alcohol self-administration. Animals in the alcohol-primed group began drinking alcohol on day 1 of the paradigm; animals in the alcohol-concurrent group began drinking on day 11. All groups start cocaine self-administration (0.8 mg/kg per infusion) on day 11. The average alcohol intake during the alcohol-priming period was 1 g/kg during the first 5 days, increasing to 1.2 g/kg during the second 5 days. Alcohol intake was similar in the alcohol-primed versus alcohol-concurrent groups from days 11 to 32 [two-way repeated-measures (RM) analysis of variance ...
Methylphenidate enhances the abuse-related behavioral effects of nicotine in rats: intravenous self-administration, drug...Methylphenidate enhances the abuse-related behavioral effects of nicotine in rats: intravenous self-administration, drug...
Stimulant drugs, including D-amphetamine, cocaine, and methylphenidate, increase cigarette smoking in controlled human laboratory experiments. Although the mechanism(s) underlying this effect are unknown, it is possible that stimulants may enhance directly the abuse-related effects of nicotine. In the present study, we characterized the behavioral pharmacological interactions between methylphenidate and nicotine in the intravenous self-administration, drug discrimination, and locomotor cross-sensitization procedures. Adult male Sprague-Dawley rats were trained to respond for intravenous nicotine (0.01 or 0.03 mg/kg/infusion) or sucrose, and the acute effects of methylphenidate (1.25-10 mg/kg) were determined; in addition, separate groups of rats were treated with methylphenidate (2.5 mg/kg) or saline before 12 consecutive nicotine (0.03 mg/kg/infusion) self-administration sessions. Next, the discriminative stimulus effects of nicotine (0.03-0.3 mg/kg) and methylphenidate (1.25-10 mg/kg), alone ...
Self-administration of barbiturates and benzodiazepines: A review<...Self-administration of barbiturates and benzodiazepines: A review<...
TY - JOUR. T1 - Self-administration of barbiturates and benzodiazepines. T2 - A review. AU - Ator, Nancy A.. AU - Griffiths, Roland R.. PY - 1987/6. Y1 - 1987/6. N2 - Studies of barbiturate and benzodiazepine self-administration are categorized by species and route of administration. Reinforcement, defined as self-administration of drug greater than of a non-drug control, has been demonstrated most often in studies employing the IV route, and there has been greater reliability in this result for a given drug among barbiturates rather than among benzodiazepines. Most studies of PO self-administration in rodents have not demonstrated reinforcement, despite a number of behavioral manipulations to induce drug intake. Studies of PO barbiturate self-administration in monkeys have demonstrated reinforcement but recent studies of PO benzodiazepine self-administration in baboons have not, although physical dependence was demonstrated. Reinforcement via the IG route has not been reliably demonstrated. ...
Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a...Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a...
TY - JOUR. T1 - Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure. AU - McFadden, Lisa M.. AU - Hadlock, Greg C.. AU - Allen, Scott C.. AU - Vieira-Brock, Paula L.. AU - Stout, Kristen A.. AU - Ellis, Jonathan D.. AU - Hoonakker, Amanda J.. AU - Andrenyak, David M.. AU - Nielsen, Shannon M.. AU - Wilkins, Diana G.. AU - Hanson, Glen R.. AU - Fleckenstein, Annette E.. PY - 2012/2/1. Y1 - 2012/2/1. N2 - Preclinical studies have demonstrated that repeated methamphetamine (METH) injections (referred to herein as a "binge" treatment) cause persistent dopaminergic deficits. A few studies have also examined the persistent neurochemical impact of METH self-administration in rats, but with variable results. These latter studies are important because: 1) they have relevance to the study of METH abuse; and 2) the effects of noncontingent METH treatment do not necessarily predict effects of ...
Role of HDAC inhibition and environmental condition in altering phases of amphetamine self-administrationRole of HDAC inhibition and environmental condition in altering phases of amphetamine self-administration
Gene-environment interactions play a significant role in drug abuse and addiction. Epigenetics (the study of how environmental stimuli alter gene expression) has gained attention in recent years as a significant contributor to many behavioral phenotypes of drug addiction. The current study sought to determine if differential rearing conditions can alter a specific epigenetic mechanism, histone deacetylase (HDAC), and how HDAC inhibition can affect drug-taking and drug-seeking behaviors differently among enriched, isolated, or standard-housed rats. Ninety male Sprague-Dawley rats were reared for 30 days in enriched (EC), isolated (IC), or standard (SC) conditions prior to amphetamine (0.03, 0.05, 0.1 mg/kg/infusion, i.v.) self-administration, extinction, or reinstatement sessions. Trichostatin A (TsA; 0.3 mg/kg, i.v.), an HDAC inhibitor, was injected 30 min prior to drug-taking or drug-seeking sessions. Results indicated that EC rats self-administered less amphetamine (0.03 mg/kg/infusion) than ...
Previous examination of binge cocaine self-administration and 2 week withdrawal from | Role of NK1 and NK2 receptors in mouse...Previous examination of binge cocaine self-administration and 2 week withdrawal from | Role of NK1 and NK2 receptors in mouse...
Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration about ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between your mesocorticolimbic and nigrostriatal pathways. and nigrostriatal pathways (substantia nigra SN and dorsal caudate-putamen CPu). Inside the mesolimbic Mouse monoclonal to Histone 3.1. Histones are the structural scaffold for the organization of nuclear DNA into chromatin. Four core histones, H2A,H2B,H3 and H4 are the major components of nucleosome which is the primary building block of chromatin. The histone proteins play essential structural and functional roles in the transition between active and inactive chromatin states. Histone 3.1, an H3 variant that has thus far only been found in mammals, is replication dependent and is associated with tene activation and gene silencing. pathway reductions had been seen in NR1 and GluR5 ...
DOPAMINE RESPONSIVENESS IN THE NUCLEUS ACCUMBENS SHELL AND CORE DURING ETHANOL AND SUCROSE SELF-ADMINISTRATION | IRIS Univ....DOPAMINE RESPONSIVENESS IN THE NUCLEUS ACCUMBENS SHELL AND CORE DURING ETHANOL AND SUCROSE SELF-ADMINISTRATION | IRIS Univ....
Ethanol is a psychoactive compound of several beverage abused by humans and it is well known that, as well as other drugs of abuse, increases dopamine (DA) transmission preferentially in the nucleus accumbens (NAc) shell. The aim of our study was to investigate by microdialysis the role of the NAc shell and core DA in the response to ethanol and to ethanol-conditioned stimuli (ethanol-CS) using an instrumental conditioning paradigm with fixed-ratio 1 (FR1). Rats were trained to acquire sucrose and ethanol oral self-administration under a FR 1 paradigm (1 nose poke corresponds to 0.25 ml administration of 20% sucrose or 10% ethanol in 20% sucrose solutions). We found that oral ethanol, either self-administered or given passively, produces an increase of DA transmission in the shell and in the core, strengthened during the self-administration session, while ethanol-CS increased DA preferentially in the NAc shell. Sucrose oral self-administration and its conditioned cues affects DA exclusively in ...
Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking<...Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking<...
TY - JOUR. T1 - Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking. AU - Marchant, N. J.. AU - Hamlin, A.S.. AU - McNally, G. P.. N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = Feb 2009; Journal title (773t) = Journal of Neuroscience. ISSNs: 0270-6474; PY - 2009/2. Y1 - 2009/2. N2 - We studied the role of lateral hypothalamus (LH) in context-induced reinstatement (renewal) of reward seeking. Rats were trained to respond for 4% (v/v) alcoholic beer or 10% (w/v) sucrose reward in one context (Context A) before extinction training in a second context (Context B). On test, rats were returned to the training context, A (ABA), or the extinction context, B (ABB). Return to the training context (ABA) produced robust reinstatement. Reversible inactivation of LH via baclofen/muscimol infusion prevented context-induced reinstatement of beer and sucrose seeking. This prevention was specific to bilateral infusions into LH. We then used the ...
ASU Scholarship Showcase | ASU Digital RepositoryASU Scholarship Showcase | ASU Digital Repository
Background 5-HT1B receptor agonists enhance cocaine intake during daily self-administration sessions but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1B receptor agonists produce similar abstinence-dependent effects on methamphetamine intake. Methods Male rats were trained to self-administer methamphetamine (0.1 mg/kg, i.v.) on low (fixed ratio 5 and variable ratio 5) and high (progressive ratio) effort schedules of reinforcement until intake was stable. Rats were then tested for the effects of the selective 5-HT1B receptor agonist, CP 94,253 (5.6 or 10 mg/kg), or the less selective but clinically available 5-HT1B/1D receptor agonist, zolmitriptan (10 mg/kg), on methamphetamine self-administration .... ...
ASU Scholarship Showcase | ASU Digital RepositoryASU Scholarship Showcase | ASU Digital Repository
Background 5-HT1B receptor agonists enhance cocaine intake during daily self-administration sessions but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1B receptor agonists produce similar abstinence-dependent effects on methamphetamine intake. Methods Male rats were trained to self-administer methamphetamine (0.1 mg/kg, i.v.) on low (fixed ratio 5 and variable ratio 5) and high (progressive ratio) effort schedules of reinforcement until intake was stable. Rats were then tested for the effects of the selective 5-HT1B receptor agonist, CP 94,253 (5.6 or 10 mg/kg), or the less selective but clinically available 5-HT1B/1D receptor agonist, zolmitriptan (10 mg/kg), on methamphetamine self-administration .... ...
Blockade or stimulation of D1dopamine receptors attenuates cue reinstatement of extinguished cocaine-seeking behavior in rats |...Blockade or stimulation of D1dopamine receptors attenuates cue reinstatement of extinguished cocaine-seeking behavior in rats |...
Rationale: D1 dopamine receptor antagonists and agonists attenuate cocaine reinstatement of cocaine-seeking behavior (i.e., responding in the absence of cocaine reinforcement). Objectives: The present
News Archives - CSJ Albany - Sisters of St. JosephNews Archives - CSJ Albany - Sisters of St. Joseph
Because peptides are most often labile in the GI tract they are usually administered by injection. The principal fragment of interest, D-Leu-OB-3, has been shown to induce significant weight loss upon i.p injection, nasal administration and oral administration. A non-invasive format is preferred in terms of patient compliance, convenience, ease of self administration, and avoidance of needle stick injuries for patients or care givers. While intranasal administration of protein and peptide drugs has shown some limited success with small peptides such as desmopressin and calcitonin, Aegis Intravail® absorption enhancement agents provide unmatched bioavailabilities - bioavailabilities comparable to injection for small as well as much larger proteins. Our studies have shown that OB-3 peptide formulated with Intravail® excipients induces significant weight loss upon nasal administration with bioavailability comparable to injection approaching or exceeding 100% compared to s.c. injection. Intravail ...
Drug Delivery Technology Market expected to reach $224.2 Billion By 2017 | MarketsandMarkets BlogDrug Delivery Technology Market expected to reach $224.2 Billion By 2017 | MarketsandMarkets Blog
http://www.marketsandmarkets.com/Market-Reports/drug-delivery-technologies-market-1085.html. Drug delivery technologies alter the release of drug so as to facilitate optimum efficacy and safety.Such technologies simplify the dosing regimen and reduce side-effects, thus boosting patient compliance. The global drug delivery market is divided into nine segments, namely, oral, pulmonary, transdermal, injectable, ocular, nasal, topical, implantable,andtransmucosal. Drug delivery technologies have grown phenomenally from plain drug reformulation and release technologies to innovative platforms that hold a huge potential for the effective delivery of biologicals and novel drugs.. The major drivers of this market are patent expiries of certain blockbuster drugs, growing demand for self administration and home healthcare devices, rising incidence of chronic diseases such as cardiovascular diseases, diabetes and cancer, growing focus on pediatric and geriatric patients, and advancing technology.However, ...
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If you are seriously impaired your helpers may need to give you glucose gel by rubbing it inside your cheek. Tell them not to put it beyond your teeth in case they get bitten.. If you are unconscious it is important that nothing is administered by mouth in case you choke. Glucagon administration is now necessary. Are all your helpers trained how to use this?. If there is no clear improvement in ten minutes with glucagon they must dial 999 / 911 and get you to hospital. After glucagon administration you can feel very sick indeed. Metoclopramide tablets or injection may be necessary. Your doctor may prescribe this for self administration at these times and if you vomit.. You will also need to build up your glycogen stores by eating your normal diet for 24 hours and meticulously avoiding low blood sugars during this time. You will need to do more frequent testing eg every 2.5 hours instead of the usual pattern and you would correct for lows but not highs.. Children dont have much glycogen to ...
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If you are seriously impaired your helpers may need to give you glucose gel by rubbing it inside your cheek. Tell them not to put it beyond your teeth in case they get bitten.. If you are unconscious it is important that nothing is administered by mouth in case you choke. Glucagon administration is now necessary. Are all your helpers trained how to use this?. If there is no clear improvement in ten minutes with glucagon they must dial 999 / 911 and get you to hospital. After glucagon administration you can feel very sick indeed. Metoclopramide tablets or injection may be necessary. Your doctor may prescribe this for self administration at these times and if you vomit.. You will also need to build up your glycogen stores by eating your normal diet for 24 hours and meticulously avoiding low blood sugars during this time. You will need to do more frequent testing eg every 2.5 hours instead of the usual pattern and you would correct for lows but not highs.. Children dont have much glycogen to ...
Colitis grave por supositorios de indometacinaColitis grave por supositorios de indometacina
Dear Editor,. Colitis occurs with exposure to various chemicals, including alcohol, radiocontrast agents, glutaraldehyde, formalin, ergotamine, hydrogen peroxide and drugs (1). Frequency of colitis induced by drugs is often under estimated. Antibiotics, 5-fluorouracil (5-FU), hydroxycarbamide, nonsteroidal anti-inflammatory drugs (NSAIDS) and aspirin are usually incriminated (2-4). We report the case of severe diarrhea and hematochezia after self administration of an indomethacin suppository to a young woman.. Case report. A 30-year-old female presented to the gastroenterology department with rectal pain, diarrhea and rectal bleeding. Her past medical history revealed migraine for 1 year. She had self administered indomethacin suppository 200 mg/day with the hope to improve headache for 3 months. The patient developed severe rectal pain and bloody diarrhea. At admission, physical examination revealed mild abdominal tenderness at lower quadrant and digital rectal examination was painful. ...
The discriminative stimulus effects of morphine in pigeons responding under a progressive ratio schedule of food presentation -...The discriminative stimulus effects of morphine in pigeons responding under a progressive ratio schedule of food presentation -...
Fingerprint Dive into the research topics of The discriminative stimulus effects of morphine in pigeons responding under a progressive ratio schedule of food presentation. Together they form a unique fingerprint. ...
Orbitofrontal and insular cortex: neural responses to cocaine-associated cues and cocaine self-administration. - PubMed - NCBIOrbitofrontal and insular cortex: neural responses to cocaine-associated cues and cocaine self-administration. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Influence of a Magnetic Guide Field on Self-Injection in Wakefield AccelerationInfluence of a Magnetic Guide Field on Self-Injection in Wakefield Acceleration
The influence of an external static field applied in the direction of propagation of a high intensity driving laser pulse on the electron trapping in laser wakefield acceleration is explored. It is shown that, in the case of self-injection, the electric charge accelerated can be enhanced in some physical situations.
Lovolkem 500mg Infusion : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Alkem Laboratories Ltd ...Lovolkem 500mg Infusion : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Alkem Laboratories Ltd ...
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Levokem 500mg Infusion : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Alkem Laboratories Ltd |...Levokem 500mg Infusion : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Alkem Laboratories Ltd |...
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Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Selective inhibition of cocaine-seeking...Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Selective inhibition of cocaine-seeking...
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Selective inhibition of cocaine-seeking behavior by a partial dopamine D(sub3) receptor agonist
The α7nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking | JEMThe α7nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking | JEM
Although these results demonstrate the presence of the α7nACh-NMDA protein complex in rat hippocampal tissue, they do not show whether the α7nACh-NMDAR complex was formed through a direct interaction or indirectly via the involvement of an accessory binding protein. Using in vitro binding assays, we provide evidence that the α7nAChR and NR2A subunits interact directly. As shown in Fig. 2 B (top), an in vitro translated [35S]α7IL2 probe hybridized with GST-NR2ACT but not GST-NR1aCT or GST alone, indicating that a direct protein-protein interaction can occur between the α7nAChR and the NR2A subunit, whereas the association between α7nAChR and NR1a subunits occurred most likely via an interaction between the NR1a and the NR2A subunits. Similarly, the [35S]NR2A probe hybridized with GST-α7IL2 but not GST-α4IL2 or GST alone (Fig. 2 B, bottom), confirming the specificity of the direct protein-protein interaction between α7nACh and NR2A subunit of NMDAR.. To confirm these results and to ...
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Doctors Dispute Self-administration Of Heart Drug - tribunedigital-orlandosentinelDoctors Dispute Self-administration Of Heart Drug - tribunedigital-orlandosentinel
A powerful drug used in hospitals to prevent deadly irregular heartbeats during heart attacks may benefit potential victims if they are prepared to administer it to themselves, Dutch researchers
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Dopamine Activity in the Nucleus Accumbens During Consummatory Phases of Oral Ethanol Self-Administration<...Dopamine Activity in the Nucleus Accumbens During Consummatory Phases of Oral Ethanol Self-Administration<...
TY - JOUR. T1 - Dopamine Activity in the Nucleus Accumbens During Consummatory Phases of Oral Ethanol Self-Administration. AU - Doyon, William M.. AU - York, Jennifer L.. AU - Diaz, Laurea M.. AU - Samson, Herman H.. AU - Czachowski, Cristine L.. AU - Gonzales, Rueben A.. PY - 2003/10. Y1 - 2003/10. N2 - Background: This present study was designed to clarify the role of dopamine in the nucleus accumbens during operant ethanol self-administration by separating bar pressing (ethanol seeking) from ethanol consumption. Furthermore, we sought to define the relationship between ethanol in the brain and the accumbal dopamine response after oral self-administration of ethanol. Methods: Two separate groups of male Long-Evans rats were trained to bar press with 10% ethanol or water. Rats were trained to elicit an escalating number of bar presses across daily sessions before gaining access to the drinking solution for 20 min. Microdialysis was performed before (during a waiting period), during, and after ...
Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats<...Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats<...
TY - JOUR. T1 - Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. AU - Rodd, Zachary. AU - McKinzie, David L.. AU - Li, Ting Kai. AU - Murphy, James M.. AU - McBride, William J.. PY - 2002/12/1. Y1 - 2002/12/1. N2 - The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine system. However, the possibility that the rewarding properties of cocaine are mediated by direct activation of this system has yielded contradictory findings. The intracranial self-administration technique is used to identify specific brain regions involved in the initiation of response-contingent behaviors for the delivery of a reinforcer. The present study assessed whether adult Wistar rats would self-administer cocaine directly into the nucleus accumbens shell (AcbSh) and core (AcbC). For each subregion, subjects were placed in standard two-lever operant chambers and randomly assigned to one of five groups for each site ...
Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in...Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in...
TY - JOUR. T1 - Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. AU - Mark, Gregory. AU - Hajnal, Andras. AU - Kinney, Anthony E.. AU - Keys, Alan S.. PY - 1999. Y1 - 1999. N2 - Rationale: The neurochemical effects of psychostimulant exposure may depend on how these drugs are encountered. A useful method for examining this issue is to compare neurotransmitter release following response-dependent, or self-administered, drug exposure and response-independent exposure. Objectives: This experiment examined the effect of active and passive cocaine administration on acetylcholine (ACh) efflux in the shell region of the nucleus accumbens (NAc) in rats. Methods: One group of rats (CSA: cocaine self-administration) was trained to lever-press for intravenous infusions of cocaine (0.42 mg/kg per infusion) on a fixed-ratio-1 schedule of reinforcement. Cocaine infusions were accompanied by the onset ...
Lobeline Attenuates d-Methamphetamine Self-Administration in Rats | Journal of Pharmacology and Experimental TherapeuticsLobeline Attenuates d-Methamphetamine Self-Administration in Rats | Journal of Pharmacology and Experimental Therapeutics
The present study demonstrates that lobeline pretreatment attenuated d-methamphetamine self-administration in rats and that tolerance did not develop rapidly, if at all, to this effect. When administered acutely, lobeline decreased responding for bothd-methamphetamine and sucrose. When administered repeatedly, however, lobeline consistently decreased d-methamphetamine self-administration, with no evidence for development of tolerance in the first 15 min of the session across seven repeated injections. However, examination of the time course revealed that the duration of the lobeline-induced attenuation was longer on day 1 (∼25 min) than on day 7 (∼15 min), suggesting some evidence for the development of tolerance. In contrast, tolerance clearly developed to the lobeline-induced decrease of sucrose reinforced responding. Taken together, these results suggest a specific decrease ind-methamphetamine self-administration following repeated lobeline pretreatment. Furthermore, the lobeline-induced ...
Repeated administration of the gaba(b) receptor positive modulator bhf177 decreased nicotine self-administration, and acute...Repeated administration of the gaba(b) receptor positive modulator bhf177 decreased nicotine self-administration, and acute...
Repeated administration of the gaba(b) receptor positive modulator bhf177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats ...
Formulation of a urate oxidase enzyme as a crystalline drugFormulation of a urate oxidase enzyme as a crystalline drug
Although naturally produced uric acid has beneficial effects in the body, its accumulation can cause diseases including gout. Rasburicase is a recombinant urate oxidase enzyme used as a drug to help the body to eliminate uric acid. It is typically administered to prevent renal failure during the treatment of tumours. The current formulation involves the lyophilised drug in a preparation suitable only for use in hospitals. A crystalline preparation could permit self administration, avoiding a hospital visit. However, to be suitable for administration by injection, the crystals needs to be smaller than 50 micrometres. Full characterisation of the drugs crystalline polymorphism is required by the health authorities -- this can be carried out by X-ray powder diffraction. There are many added benefits from using a crystalline form of a drug: it permits better control over the release rate into the system by an optimisation of the crystals size and polymorphism, and it should also offer an extended ...
Obama Orders US Government To Begin Preparing For Biological Attack » Alex Jones Infowars: Theres a war on for your mind!Obama Orders US Government To Begin Preparing For Biological Attack » Alex Jones' Infowars: There's a war on for your mind!
efoods]"This policy would seek to: (1) mitigate illness and prevent death; (2) sustain critical infrastructure; and (3) complement and supplement State, local, territorial, and tribal government medical countermeasure distribution capacity," the order said. "The US Postal Service has the capacity for rapid residential delivery of medical countermeasures for self administration across all communities in the United States," the order added. The US Health and Human Services Secretary Kathleen Sebelius and Homeland Security Secretary Janet Napolitano were instructed to work with the post office to develop a "dispensing model for US cities to respond to a large-scale biological attack, with anthrax as the primary threat consideration." The order calls for the model to be drawn up within 180 days, but gives no details as to whether the idea of using the US postal system to assist Americans in the wake of a biological attack is a new one. The United States has sought to bolster its capacity to respond ...
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Initial worsening of signs/symptoms (eg, bone pain, ureteral obstruction, spinal cord compression) may occur; monitor closely in metastatic vertebral lesions, urinary obstruction, hematuria. Monitor serum testosterone, PSA. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Increased risk of convulsions in patients with history of seizures, epilepsy, cerebrovascular disorder, CNS anomalies or tumors. Risk of QT prolongation in long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities (correct and monitor), or CHF; consider monitoring ECGs. Instruct patient on correct self administration. Embryo-fetal toxicity. Pregnancy. Nursing mothers: not recommended. ...
The role of medial prefrontal cortex in extinction and reinstatement of alcohol-seeking in rats - Willcocks - 2012 - European...The role of medial prefrontal cortex in extinction and reinstatement of alcohol-seeking in rats - Willcocks - 2012 - European...
The prelimbic (PL) and infralimbic (IL) medial prefrontal cortex (mPFC) are thought to play opposing roles in drug-seeking behaviour. Specifically, the PL promotes drug-seeking whereas the IL is necessary for the inhibition of drug-seeking during extinction. We studied the roles of the PL, IL and dorsal peduncular PFC (DP) in the expression of context-induced reinstatement, reacquisition and extinction of alcoholic beer-seeking. In context-induced reinstatement (renewal), animals were trained to nosepoke for alcoholic beer (context A), extinguished (context B) and then tested in context A and B. In reacquisition, animals received the same instrumental training and extinction without any contextual manipulation. On test, alcoholic beer was again available and responding was compared with naive controls. Just prior to the test, rats received bilateral infusion of baclofen/muscimol into the PL, IL or DP. Reversible inactivation of the PL attenuated ABA renewal but augmented reacquisition. ...
PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis - Research - The Capital Region...PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis - Research - The Capital Region...
Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaines reinforcing actions. Here, we establish the importance of PICK1 for behavioral effects observed after both acute and repeated administration of cocaine. In PICK1 knock-out (KO) mice, the acute locomotor response to a single injection of cocaine was markedly attenuated. Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. Reduced behavioral effects of cocaine were not associated with decreased striatal DAT distribution and most likely not caused by the ∼30% reduction in synaptosomal DA uptake observed in PICK1 KO mice. The PICK1 KO mice demonstrated preserved behavioral responses to DA receptor agonists supporting intact downstream DA ...
Lirias: Comparison of self-administration and face-to-face interview for surveys of low back pain in adolescentsLirias: Comparison of self-administration and face-to-face interview for surveys of low back pain in adolescents
The aim of this study was to compare self-administration with face-to-face interview in the investigation of low back pain in adolescents. Fifty-seven adolescents with low back pain (mean age 17.3 y; range 16-18) first completed a questionnaire and were then invited to an interview. Analysis included item completion, percentages of agreement and weighted kappa. Item completion rates were high and comparable between self-administration and interview. Information between both methods was analogous for severity and localization of problems, sleep behaviour, medical consultation and sports/leisure activities. Onset, progression, duration of low back pain and some items on the influence of movement/positions presented less comparable data. Conclusion: Even when two different methods of data acquisition are used, results suggest that the method used does not change the interpretation of results in the case of most items ...
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Stimulation of dopamine D2/D3 but not D1 receptors in the central amygdala decreases cocaine-seeking behavior - Fingerprint ...Stimulation of dopamine D2/D3 but not D1 receptors in the central amygdala decreases cocaine-seeking behavior - Fingerprint ...
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When Tasting Your Favorite Beer, Are You in Your Right Mind?When Tasting Your Favorite Beer, Are You in Your 'Right' Mind?
Drug-seeking behavior can be prompted or cued by certain kinds of drug-associated stimuli, suggested researchers at the Indiana University School of Medicine.
Actualités du Neurocentre MagendieActualités du Neurocentre Magendie
Physical exercise, which can be addictogenic on its own, is considered a therapeutic alternative for drug craving. Exercise might thus share with drugs the ability to strengthen excitatory synapses onto ventral tegmental area (VTA) dopaminergic neurones, as assessed by the ratio of AMPA receptor (AMPAR)-mediated excitatory postsynaptic currents (EPSCs) to NMDA receptor (NMDAR)-mediated EPSCs. As did acute cocaine, amphetamine, or Δ9 -tetrahydrocannabinol (THC) pretreatments, an acute 1-h wheel-running session increased the AMPAR/NMDAR ratio in VTA dopaminergic neurones. To dissect the respective influences of wheel-running seeking and performance, mice went through an operant protocol wherein wheel-running was conditioned by nose poking under fixed ratio schedules of reinforcement. Conditioned wheel-running increased the AMPAR/NMDAR ratio to a higher extent than free wheel-running, doing so although running performance was lower in the former paradigm than in the latter. Thus, the cue-reward ...
Self-injection of amphetamine directly into the brainSelf-injection of amphetamine directly into the brain
Rats learned to self-administer d-amphetamine (10 micrograms/microliter) through a cannula implanted in the nucleus accumbens. They responded more frequently for 65 +/- 15 nl of amphetamine than for equal amounts of saline. When presented with two levers (one amphetamine, one blank) they responded m …
Application of human laboratory data for the assessment of performance in workplace settings: practical and theoretical...Application of human laboratory data for the assessment of performance in workplace settings: practical and theoretical...
TY - JOUR. T1 - Application of human laboratory data for the assessment of performance in workplace settings. T2 - practical and theoretical considerations.. AU - Heishman, S. J.. AU - Henningfield, J. E.. PY - 1990. Y1 - 1990. UR - http://www.scopus.com/inward/record.url?scp=0025523509&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0025523509&partnerID=8YFLogxK. M3 - Article. C2 - 2132770. AN - SCOPUS:0025523509. VL - 100. SP - 167. EP - 174. JO - NIDA Research Monograph Series. JF - NIDA Research Monograph Series. SN - 1046-9516. ER - ...
Most recent papers with the keyword Pharmacotherapy | Read by QxMDMost recent papers with the keyword Pharmacotherapy | Read by QxMD
Commonalities in addictive behavior, such as craving, stimuli-driven drug seeking, and a high propensity for relapse following abstinence, have pushed for a unified theory of addiction that encompasses most abused substances. This unitary theory has recently been challenged - citing distinctions in structural neural plasticity, biochemical signaling, and neural circuitry to argue that addiction to opioids and psychostimulants is behaviorally and neurobiologically distinct. Recent more selective examination of drug-induced plasticity has highlighted that these two drug classes promote an overall reward circuitry signaling overlap through modifying excitatory synapses in the nucleus accumbens - a key constituent of the reward system ...
Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development...Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development...
Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle ...
Stress and Addiction Part 3: Molecular Changes - Dr. Simon Says ScienceStress and Addiction Part 3: Molecular Changes - Dr. Simon Says Science
This is part three on my series of posts looking at Stress and Addiction. To recap: weve seen that, in laboratory studies, stress increases susceptibility to drug addiction. Stress not only increases the self-administration of drugs in adult rats but stress during an early age can have a long-lasting effect on drug-taking behavior. Today, well…
NeuroElectro :: ArticleNeuroElectro :: Article
Article: Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. ...
NIVESTYM™ (filgrastim-aafi) Dosage and Administration | Pfizer Medical Information - SwedenNIVESTYM™ (filgrastim-aafi) Dosage and Administration | Pfizer Medical Information - Sweden
Patient self-administration and administration by a caregiver may benefit from training by a healthcare professional. Training should aim to demonstrate to those patients and caregivers how to measure the dose using the prefilled syringe, and the focus should be on ensuring that a patient or caregiver can successfully perform all of the steps in the Instructions for Use of NIVESTYM prefilled syringe with BD UltraSafe Plus™ Passive Needle Guard. If a patient or caregiver is not able to demonstrate that they can measure the dose and administer the product successfully, you should consider whether the patient is an appropriate candidate for self-administration of NIVESTYM [see Instructions for Use].. NIVESTYM prefilled syringe with BD UltraSafe Plus™ Passive Needle Guard is not designed to allow for direct administration of doses of less than 0.3 mL (180 mcg). The spring-mechanism of the needle guard apparatus affixed to the prefilled syringe interferes with the visibility of the graduation ...
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Family s Food Insecurity Linked to the Smoking AdultFamily s Food Insecurity Linked to the Smoking Adult
A new study has found that kids and adults living with adult smokers appear less likely to have daily access to enough healthy food compared with those living with non-smoking adults,
Assistance with Self-Administration: Medication Savvy for Nursing Assistants Course Summary | CEUfast Nursing Continuing...Assistance with Self-Administration: Medication Savvy for Nursing Assistants Course Summary | CEUfast Nursing Continuing...
Summary - This course prepares Certified Nursing Assistants to effectively and safely assist residents in Assisted Living facilities to receive their medications safely.
Monifah Speaks on Cocaine Addiction, Heavy D, & Reality ShowMonifah Speaks on Cocaine Addiction, Heavy D, & Reality Show
Do you remember Monifah, Uptown Records first lady of the mid-90s? Well, the smooth singer is back and recently revealed the reason behind her long hiatus.
Examine This Report on cocaine kingExamine This Report on cocaine king
The vast majority of persons I know do drink additional when employing cocaine but for a distinct motive. Although I do not know how it works, whenever you use cocaine it is extremely not easy to get pissed, It appears to sober you up, and so at such a time whenever you could get in touch with it a night, you can actually hold likely. This can cause complications of its very own however ...
Man on cocaine charges must engage with drugs counsellor - judge | Southern StarMan on cocaine charges 'must engage' with drugs counsellor - judge | Southern Star
AN ENNISKEANE man who was convicted of selling cocaine has been told by a Circuit Court judge that he must engage with his drugs counsellor.At a recent sitting of the Circuit Court in Bandon, Ian Murphy (33) of 4 Tír na Gréine, Enniskeane appealed a seven-month sentence which h
Could I experience acute withdrawal?Could I experience acute withdrawal?
Question posted in: klonopin, lexapro, withdrawal, prescription, tapering - Additional details: My dr.prescribed Lexapro with Klonopin 3 weeks ago.I ...
Drunken driver pleads guilty to being on cocaine when he fatally hit 2-year-old girlDrunken driver pleads guilty to being on cocaine when he fatally hit 2-year-old girl
A 55-year-old Ypsilanti Township man pleaded guilty Thursday to driving under the influence of cocaine in a July incident that killed a 2-year-old girl.
Why cocaine cravings wont go away | Health24Why cocaine cravings won't go away | Health24
Researchers say they can now point to a specific molecule in the brain as a possible target for treatment to prevent cocaine relapses for addicts.
Reviews for Rats on Cocaine - Ep # 1Reviews for Rats on Cocaine - Ep # 1
Hey! To start this decade right, we believe Newgrounds should be ad-free for EVERYONE. For this to work, we need people who have the means to become paying supporters. For just $3 per month or $25 for the year, you can help this happen and get some nice perks!. For the month of April we have disabled ads on all E-M content. We need 65 people to reach our goal of 3,000 active supporters. If we hit that, well continue with a new goal in May!. Please check out our Supporter Upgrade and consider coming aboard!. ...
The Foundations of Normal and Abnormal Psychology/Part 2/XXII - Wikisource, the free online libraryThe Foundations of Normal and Abnormal Psychology/Part 2/XXII - Wikisource, the free online library
In other words the representative states in the series of reproduction all refer to the original experience AA and each preceding state modifies the succeeding one, but the succeeding state does not include consciously the previous reproduction and recognition. The partial intersecting of the circles indicates that the successive states do not include their predecessors, but are only influenced and modified by them. The state, however, gets enlarged the further situated it is in the progression of the series. Each state inherits only the modifications accumulated by the preceding ones, but it does not inherit the cognition or recognition of the state itself.. In this respect the series of states going to make up the recognitive moment differs from that of synthetic type. The synthetic moment reproduces by reinstatement with modifications accumulated in the course of the process of reproductions. The recognitive moment on the contrary does not reproduce by reinstatement of presentation, but by ...
Hemsyl Inj вTheoryHemsyl Inj вTheory
Park Ridge, IL American Academy of Orthopaedic Surgeons;619в627. In the sagittal plane typical areas of 1 8 14 26 9 13 7 3 5 10 12 4 Hemsyl Inj в Fig.
NOTHING IS MORE EXPENSIVE THAN FREENOTHING IS MORE EXPENSIVE THAN FREE
However, the daily energy clearing group is just $27 a month. Its an in-depth daily daily session with the SRC.. You wont find anything comparable for under $99 a month. In fact, even one-time sessions such as the group gets daily can run into the hundreds ...
US Pushes for an Inclusive EgyptUS Pushes for an 'Inclusive' Egypt
Thousands have been rallying for days near a mosque in northeast Cairo to demand the reinstatement of ousted Islamist president Mohamed Morsi
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LFS Forum - OLFSL StreamingLFS Forum - OLFSL Streaming
Hi all; I just wanted to announce that after a good test session I am happy to report that I should be able to video stream almost every OLFSL race this s ...
Northern TransylvaniaNorthern Transylvania
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Coffee County Central High SchoolCoffee County Central High School
Micky AdamsMicky Adams
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Etowah High School (Georgia)Etowah High School (Georgia)
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AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
Self AdministrationAdministration, OralAdministration, SublingualEncyclopedias as TopicNitroglycerinLipSphenoid BoneNasal SeptumAngina PectorisCosts and Cost AnalysisResearchHealth Care CostsDecision MakingUnited StatesConservation of Natural ResourcesCost-Benefit AnalysisDirectories as TopicSoftwareUser-Computer InterfaceAlgorithmsProgramming LanguagesSoftware DesignComputational BiologyElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetGolfPensionsHealth ManpowerDelegation, ProfessionalSalaries and Fringe BenefitsPersonnel ManagementFederal Government
Roches Xolair sBLA for Self Administration Accepted by FDARoche's Xolair sBLA for Self Administration Accepted by FDA
Ethanol Self-Administration Procedures | iniastress.orgEthanol Self-Administration Procedures | iniastress.org
Schedule-induced oral self administration of etonitazene | MetaSchedule-induced oral self administration of etonitazene | Meta
The Catholic Message Board • View topic - Ashes: Self-administration?The Catholic Message Board • View topic - Ashes: Self-administration?
Whole Foods Market Recalls Cheeses From 9 Stores Because of Possible Health RiskWhole Foods Market Recalls Cheeses From 9 Stores Because of Possible Health Risk
Assessment of Immunomodulatory Activity of the Biofield Energy Treated Novel Herbomineral Formulation After Oral Administration...Assessment of Immunomodulatory Activity of the Biofield Energy Treated Novel Herbomineral Formulation After Oral Administration...
Sublabial administration - WikipediaSublabial administration - Wikipedia
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Lease administration - WikipediaLease administration - Wikipedia
Award and Administration GuideAward and Administration Guide
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Medical Emergencies | AdministrationMedical Emergencies | Administration
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Self AdministrationAdministration, OralAdministration, SublingualEncyclopedias as TopicNitroglycerinLipSphenoid BoneNasal SeptumAngina PectorisCosts and Cost AnalysisResearchHealth Care CostsDecision MakingUnited StatesConservation of Natural ResourcesCost-Benefit AnalysisDirectories as TopicSoftwareUser-Computer InterfaceAlgorithmsProgramming LanguagesSoftware DesignComputational BiologyElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetGolfPensionsHealth ManpowerDelegation, ProfessionalSalaries and Fringe BenefitsPersonnel ManagementFederal Government
Available for self-administrationFHWAObamaElectionPotentiallyFederal Highway AdminiTransportation Security AdminWashingtonProvideNetworkNational Archives and RInstitutionToolsUsersPortalVice PresidentGuideChangeSecurityDepartmentDrugOfficeSystemAssociationEnsureServices
Available for self-administration1
FHWA3
  • The Federal Highway Administration (FHWA) is an agency within the U.S. Department of Transportation that supports State and local governments in the design, construction, and maintenance of the Nation's highway system (Federal Aid Highway Program) and various federally and tribal owned lands (Federal Lands Highway Program). (dot.gov)
  • The Federal Highway Administration (FHWA) was created on October 15, 1966, after having had several predecessor organizations. (dot.gov)
  • The Federal Highway Administration (FHWA) Division Offices are local field offices that provide leadership, guidance, and direction to State Departments of Transportation in the project development and delivery of transportation projects. (dot.gov)
Obama3
Election3
  • 2008-10-21T16:40:32-04:00 https://images.c-span.org/Files/e0b/281903-m.jpg Doug Chapin previewed the election administration issues in each state. (c-span.org)
  • Doug Chapin previewed the election administration issues in each state. (c-span.org)
  • A somewhat amusing side effect of this process is the tradition of "midnight regulations": In a frantic rush between an election and a new administration from the other party, the old president and his minions rush to finalize everything they possibly can, cutting whatever corners need to be cut. (nationalreview.com)
Potentially1
Federal Highway Admini1
  • Through financial and technical assistance to State and local governments, the Federal Highway Administration is responsible for ensuring that America's roads and highways continue to be among the safest and most technologically sound in the world. (dot.gov)
Transportation Security Admin2
  • The Transportation Security Administration (TSA) protects the nation's transportation systems to ensure freedom of movement for people and commerce. (usa.gov)
  • Join us for a discussion of why Congress should privatize airport security and abolish the Transportation Security Administration. (cato.org)
Washington2
  • WASHINGTON - The Trump administration formally activated its new asylum crackdown on Thursday, a move that could make it even more difficult for immigrants seeking U.S. refuge. (usatoday.com)
  • by Georgi N. Gaydadjiev, Bruno Crispo, Rutger F. H. Hofman - In Proceedings of the 20th Conference on Large installation System Administration (Washington, DC, December 03 - 08, 2006). (psu.edu)
Provide2
Network3
National Archives and R2
Institution2
  • NARA was officially given its independence from the GSA with the passing of the Records Administration Act of 1984, thus giving birth to the institution we have today. (wikipedia.org)
  • But that just lends credence to the theory that Bolton got kicked over to the UN not because the Bush administration wanted someone to tear down the institution, but just because Condoleeza Rice wanted him out of the State Department. (motherjones.com)
Tools2
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Portal5
Vice President1
  • John Pepper, the vice president of finance and administration, has said that about two-thirds of the procurement budget can be made more efficient, and other finance officials said a number of projects have been implemented or are being developed to further tighten the department's belt. (yaledailynews.com)
Guide1
Change1
  • The veteran retailer also would not comment on whether he planned to call an extraordinary general meeting to force change at Myer, and said he believed administration may be the most likely outcome for the beleaguered merchant. (smh.com.au)
Security1
  • This paper presents the design, implementation, and evaluation of the RFID Guardian, the first-ever unified platform for RFID security and privacy administration. (psu.edu)
Department2
  • Billionaire retailer Solomon Lew has blasted efforts by Myer management to restructure its board and said the company is headed for administration in a further escalation of tensions between the struggling department store and its shareholders. (smh.com.au)
  • Catalina Lauf, who served in the Department of Commerce under the Trump administration, launched a bid Thursday to oust Kinzinger. (nationalreview.com)
Drug1
Office1
  • The Office of the United Nations High Commissioner for Human Rights is organising an expert consultation on human rights considerations relating to the administration of justice through military tribunals and on the role of the integral judicial system in combating human rights violations. (ohchr.org)
System1
Association2
  • The new administration will be busy "undoing the harms that have been actively perpetrated" by the Donald J. Trump White House, said Jeffrey Mittman, executive director of the National Employment Lawyers Association. (forbes.com)
  • With the issuance of these memos, the administration has turned U.S. asylum law on its head," said Anastasia Tonello, president of the American Immigration Lawyers Association. (usatoday.com)
Ensure1
Services1