Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Placebo Effect: An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.Selenomethionine: Diagnostic aid in pancreas function determination.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Glutathione Peroxidase: An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 126.96.36.199.Selenoproteins: Selenoproteins are proteins that specifically incorporate SELENOCYSTEINE into their amino acid chain. Most selenoproteins are enzymes with the selenocysteine residues being responsible for their catalytic functions.Selenoprotein P: An extracellular selenoprotein that contains most of the SELENIUM in PLASMA. Selenoprotein P functions as an antioxidant and appears to transport selenium from the LIVER to peripheral tissues.Organoselenium Compounds: Organic compounds which contain selenium as an integral part of the molecule.Selenic Acid: A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.Selenium Radioisotopes: Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.Selenious Acid: A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Selenocysteine: A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Selenium Oxides: Inorganic compounds formed through the oxidation of selenium.Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.Trace Elements: A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Diet: Regular course of eating and drinking adopted by a person or animal.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Selenium-Binding Proteins: A group of proteins that covalently attach to selenium or SELENIUM-containing compounds.Intention to Treat Analysis: Strategy for the analysis of RANDOMIZED CONTROLLED TRIALS AS TOPIC that compares patients in the groups to which they were originally randomly assigned.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Thioredoxin-Disulfide Reductase: A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 188.8.131.52Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Single-Blind Method: A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Yeast, Dried: The dry cells of any suitable strain of SACCHAROMYCES CEREVISIAE or CANDIDA. It can be obtained as a by-product from the brewing of beer or by growing on media not suitable for beer production. Dried yeast serves as a source of protein and VITAMIN B COMPLEX.Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.Recurrence: The return of a sign, symptom, or disease after a remission.beta Carotene: A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Zinc: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Nutritional Status: State of the body in relation to the consumption and utilization of nutrients.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Premedication: Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Spectrophotometry, Atomic: Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Selenoprotein W: A single SELENOCYSTEINE containing protein that binds reduced GLUTATHIONE and can act as an antioxidant.Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Bronchodilator Agents: Agents that cause an increase in the expansion of a bronchus or bronchial tubes.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Food, Fortified: Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)Deficiency Diseases: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Probiotics: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Micronutrients: Essential dietary elements or organic compounds that are required in only small quantities for normal physiologic processes to occur.Isotopes: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)alpha-Tocopherol: A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.White Muscle Disease: A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)Homeopathy: A system of therapeutics founded by Samuel Hahnemann (1755-1843), based on the Law of Similars where "like cures like". Diseases are treated by highly diluted substances that cause, in healthy persons, symptoms like those of the disease to be treated.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Arnica: A plant genus of the family ASTERACEAE. The dried flower heads of Arnica montana are used externally as a counterirritant and tincture for sprains and bruises, either as crude extract or in homeopathic dilution (HOMEOPATHY). Arnica contains volatile oils (OILS, VOLATILE), arnicin, arnisterol, FLAVONOIDS; TANNINS; and resin. The common name of Wolf's Bane is similar to the common name for ACONITUM.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Acute Disease: Disease having a short and relatively severe course.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Pain, Postoperative: Pain during the period after surgery.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Age-Related Eye Disease Study Research Group (2001). "A randomized, placebo-controlled, clinical trial of high-dose ... Klein, EA (2004). "Selenium and vitamin E cancer prevention trial". Annals of the New York Academy of Sciences. 1031: 234-41. ... Age-Related Eye Disease Study Research Group (2001). "A randomized, placebo-controlled, clinical trial of high-dose ... The range of intakes from both diet and supplements in this group was 21.6 to 1,000 IU (32 to 1,500 mg), with the median intake ...
... or placebo and followed each patient for a period of two years. In the group that received three 100 mg capsules of coenzyme ... Soon after, the product was further developed into the product sold today as Bio-Selenium+Zinc, which is still a cornerstone of ... fewer heart-related deaths compared with the placebo group. Also, there was a significant reduction in the need for ... The commercial success of Bio-Selenium+Zinc paved the road for the first daughter companies that were established in Sweden, ...
... selenium and placebo, vitamin E and placebo, or two placebos. It was one of the largest cancer prevention trials ever conducted ... A 2011 study based on the trial found that the risk of prostate cancer was elevated by 17% in the group that took vitamin E ... The review concluded that "no convincing evidence suggests that selenium supplements can prevent cancer in humans." Selenium ... "Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk". JNCI Journal of the ...
Berkely Publishing Group. New York, USA. 2001:223. *↑ Segala, M. (editor). Disease Prevention and Treatment 3rd Edition. Life ... Effects of dietary selenium on mood in healthy men living in a metabolic research unit. Biol Psychiatry. 39(2):121-128, 1996. ... Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed post-menopausal women. Psychother Psychosom. 59( ... Avery Publishing Group, New York, USA. 1994:71. *↑ Erdmann, Robert & Jones, Meirion. The Amino Revolution. Century Hutchinson. ...
Volz HP, Kieser M (1997). "Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25- ... The "safe" hydrangeas belong to the Hydrangea serrata Amacha ("sweet tea") Cultivar Group. Jiaogulan, (also known as xiancao or ... Ayurvedic tea has also been found to contain nutrients including calcium, potassium, vanadium, iron, manganese, selenium and ...
The study was stopped for ethical reasons to give the placebo group the same treatment. Alpharadin uses bone targeted Radium- ... There is some tentative evidence for foods containing lycopene and selenium. Diets rich in cruciferous vegetables, soy, beans ... The predictions are based on the experience of large groups of patients suffering from cancers at various stages. In 1941, ... 2 (8): 1-4. BMJ Group (8 December 2009). "Prostate cancer: How far has your cancer spread? The TNM system". London: Guardian.co ...
January 2009). "Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E ... In the control group, 151 of the 195 patients reported some urinary incontinence (EER=.755, CER=.774, RRR=.0245, ARR=.019, NNT= ... placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma". J Natl Cancer ... Neither selenium nor vitamin E have been found to be effective in preventing prostate cancer. The trade-off dilemma refers to ...
NY: Avery Group, 3, ISBN 0-89529-769-8. *^ Drouin G, Godin JR, Pagé B (2011). "The genetics of vitamin C loss in vertebrates". ... Selenium and a Reduced Risk of Site-specific Cancers, FDA-2008-Q-0323 U.S. Food and Drug Administration. ... placebo-controlled trials". Am. Heart J. 162 (6): 959-965. doi:10.1016/j.ahj.2011.09.012. PMID 22137067.. ... a b Nutrition for Athletes, International Olympic Committee Nutrition Working Group of the Medical and Scientific Commission of ...
... versus a placebo. Compared with the placebo, men taking a daily multivitamin had a small but statistically significant ... However, specific groups of people may benefit from multivitamin supplements, for example, people with poor nutrition or those ... selenium, borate, zinc, calcium, magnesium, manganese, molybdenum, betacarotene, and/or iron. Multivitamins are typically ... A 2012 meta-analysis of ten randomized, placebo-controlled trials published in the Journal of Alzheimer's Disease found that a ...
Vadgama JV, Wu Y, Shen D, Hsia S, Block J (2000). "Effect of selenium in combination with Adriamycin or Taxol on several ... Complementary and alternative cancer treatments are often grouped together, in part because of the adoption of the phrase " ... Medicine portal Diet and cancer Clinical trial Placebo effect Pseudoscience List of topics characterized as pseudoscience " ... Milk thistle Proton therapy Selenium (Selenomethionine and Se-methylselenocysteine) Most studies of complementary and ...
Many multivitamin formulas contain vitamin C, B1, B2, B3, B5, B6, B7, B9, B12, A, E, D2 (or D3), K, potassium, iodine, selenium ... versus a placebo. Compared with the placebo, men taking a daily multivitamin had a small but statistically significant ... Zhao LQ, Li LM, Zhu H, The Epidemiological Evidence-Based Eye Disease Study Research Group EY (February 2014). "The effect of ... Safe upper levels for vitamins and minerals - Report of the UK Food Standards Agency Expert Group on Vitamins and Minerals ...
This includes vitamin A, C, the alpha-tocopherol form of vitamin E, selenium, zinc, and ... in the 75-84 group and to 42% in the greater than 84 group. Prevalence rates in less developed regions are lower. The ... placebo-controlled phase I trial". Lancet. 372 (9634): 216-23. doi:10.1016/S0140-6736(08)61075-2. PMID 18640458.. ... EURODEM Incidence Research Group". Neurology. 53 (9): 1992-97. doi:10.1212/wnl.53.9.1992. PMID 10599770.. ...
van Deventer SJ, Wedel MK, Baker BF, Xia S, Chuang E, Miner PB (2006). "A Phase II dose ranging, double-blind, placebo- ... The functional enrichment analysis of this group of genes using gene ontology showed that there are many genes related with ... and selenium are extremely common and benefit from replacement therapy. Dietary interventions, including certain exclusion ... Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn's disease and ...
A group of scientific experts assembled in London on October 23, 2013, to discuss the scope and appropriate use of the term " ... placebo-controlled trials". Lancet Infect Dis. 6 (6): 374-82. doi:10.1016/S1473-3099(06)70495-9. PMID 16728323.. ... Bridging the gap between consumers, green groups, and industry". Electronic Journal of Biotechnology. 9 (4): E49-55. doi: ... In addition, some groups of women respond to treatment based upon ethnicity, age, number of sexual partners, pregnancy, and the ...
A group of scientific experts assembled in London on October 23, 2013, to discuss the scope and appropriate use of the term ... placebo-controlled trials". Lancet Infect Dis. 6 (6): 374-82. doi:10.1016/S1473-3099(06)70495-9. PMID 16728323.. ... Bridging the gap between consumers, green groups, and industry". Electronic Journal of Biotechnology. 9 (4): E49-55. doi: ... This treatment is based on the observation that 70% of healthy females have a group of bacteria in the genus Lactobacillus that ...
Randomised, placebo-controlled trial". Br J Psych. 181: 22-28. doi:10.1192/bjp.181.1.22. PMID 12091259. Satia JA, Littman A, ... Patrick Lyn (December 1999). "Nutrients and HIV: part one -- beta carotene and selenium" (PDF). Altern Med Rev. 4 (6): 403-13. ... and some research groups continue to investigate whether it has an effect as a possible cancer treatment. In general, the ... and megavitamin therapies for a group of rare inborn errors of metabolism. A review in the Annals of Internal Medicine ...
It has two hydroxyl groups bonded to a benzene ring in a para position. It is a white granular solid. Substituted derivatives ... a randomized double-blind placebo-controlled trial". The British Journal of Dermatology. 173 (1): 209-217. doi:10.1111/bjd. ... Selenium disulfide (selenium sulfide). *Xenysalate. *Zinc pyrithione (pyrithione zinc). *Antihistamines. *Calcineurin ... Hydroquinone can lose a proton from both hydroxyl groups to form a diphenolate ion. The disodium diphenolate salt of ...
... some evidence suggests that athletes who take it are merely experiencing a placebo effect. ... Compounds containing the sulfate group. H2SO4 He Li2SO4 BeSO4 B esters. ROSO3−. (RO)2SO2 (NH4)2SO4. [N2H5]HSO4. (NH3OH)2SO4. ...
EURODEM Incidence Research Group». Neurology. 53 (9): 1992-7. PMID 10599770. !CS1 manut: Nomes múltiplos: lista de autores ( ... A Randomised, Blinded, Placebo-Controlled Trial in Dementia Patients Continuing or Stopping Neuroleptics (The DART-AD Trial)». ... Loef M, Schrauzer GN, Walach H (2011). «Selenium and Alzheimer's disease: a systematic review». Journal of Alzheimer's Disease ... Placebo-controlled Phase I Trial». Lancet. 372 (9634): 216-23. PMID 18640458. doi:10.1016/S0140-6736(08)61075-2. !CS1 manut: ...
EURODEM Incidence Research Group. Neurology. 1999, 53 (9): 1992-97. PMID 10599770. doi:10.1212/wnl.53.9.1992 （英语）.. ... Loef M, Schrauzer GN, Walach H. Selenium and Alzheimer's disease: a systematic review. Journal of Alzheimer's Disease (Review ... Placebo-controlled Phase I Trial. Lancet. 2008, 372 (9634): 216-23. PMID 18640458. doi:10.1016/S0140-6736(08)61075-2 （英语）.. ... Guerreiro R, Wojtas A, Bras J; The Alzheimer Genetic Analysis Group; 等. TREM2 variants in Alzheimer's disease. The New England ...
A group of atoms in a molecule (e.g., CH2) may have multiple modes of oscillation caused by the stretching and bending motions ... 1873: Willoughby Smith discovered the photoconductivity of selenium.. *1878: Samuel Pierpont Langley invents the first ... Hargate, G (2006). "A randomised double-blind study comparing the effect of 1072-nm light against placebo for the treatment of ... This can be used to gain information about the sample composition in terms of chemical groups present and also its purity (for ...
"Heart Group. Cochrane Database of Systematic Reviews. John Wiley & Sons (6): CD008684. doi:10.1002/14651858.CD008684.pub2 - via ... placebo-controlled study". Journal of Clinical Pharmacology. 33 (3): 226-229. doi:10.1002/j.1552-4604.1993.tb03948.x. PMID ... where Q refers to the quinone chemical group and 10 refers to the number of isoprenyl chemical subunits in its tail. ... Lipid and Blood Pressure Meta-analysis Collaboration Group. 90 (1): 24-34. doi:10.1016/j.mayocp.2014.08.021. PMID 25440725.. ...
Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum Technetium Ruthenium Rhodium Palladium Silver ... The Gale Group, Inc. Retrieved December 16, 2007.. *^ "Goddard-1926". NASA. Archived from the original on November 8, 2007. ... The pharmacological effect is doubted; a placebo effect is a more likely explanation. Available studies support a ... Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group on the periodic ...
One group of researchers showed that corneal hypoxia exacerbated Pseudomonas binding to the corneal epithelium, internalization ... Later work that used these ChromaGen lenses with dyslexics in a randomised, double-blind, placebo controlled trial showed ... Lenses with covalently attached selenium molecules have been shown to reduce bacterial colonization without adversely affecting ... CLARE (contact lens associated red eye) is a group of inflammatory complications from lens wear ...
Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum Technetium Ruthenium Rhodium Palladium Silver ... The Gale Group, Inc. Retrieved December 16, 2007.. *^ "Goddard-1926". NASA. Archived from the original on November 8, 2007. ... The pharmacological effect is doubted; a placebo effect is a more likely explanation. Available studies support a ... 2 concentration in the lungs helps to displace carbon monoxide from the heme group of hemoglobin. Oxygen gas is ...
Volz HP, Kieser M (1997). "Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25- ... The "safe" hydrangeas belong to the Hydrangea serrata Amacha ("sweet tea") Cultivar Group. ... Ayurvedic tea has also been found to contain nutrients including calcium, potassium, vanadium, iron, manganese, selenium and ...
Several studies have found Arnica montana to be no more effective than a placebo in relieving pain, swelling, and bruising. ... "Effect of homeopathic Arnica montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled ... Robertson A, Suryanarayanan R, Banerjee A. "Homeopathic Arnica montana for post-tonsillectomy analgesia: a randomised placebo ... Iodine and Selenium *Journaling *Keeping Abreast of the News *Ketogenic Diet *Latissimus Dorsi Flap Surgery ...
... but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium. Because ... and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken ... independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National ... one took selenium and a vitamin E placebo; one took vitamin E and a selenium placebo; and the final group received placebos of ...
Selenium supplementation does not prevent diabetes and might actually precipitate it, a large prevention trial has suggested. ... there were 58 in the selenium group and 39 in the placebo group. Seleniums lack of beneficial effect on diabetes risk ... The selenium and placebo groups did not differ with respect to baseline characteristics. Overall, 97 new cases of type 2 ... although selenium-driven antioxidant activity plateaus at plasma selenium levels of 70 to 90 ng/mL. As a result, selenium ...
Selenium, a trace mineral found in grains, nuts and meats, and vitamin E whether taken alone or in combination do not prevent ... The participants were divided into four intervention groups: selenium, vitamin E, both selenium and vitamin E, and placebos. ... slightly increased risks of prostate cancer in the vitamin E group and type two diabetes mellitus in the selenium group. Both ... selenium group, trace mineral, type two diabetes, vitamin e ... Extra selenium can spur type-2 diabetes risk - Mar 01, 2012. ...
144 patients with cirrhosis will be randomized to one of 4 treatment groups, including a placebo. After treatement for 4 weeks ... It is possible that certain diseases result in selenium deficiency because of the form of selenium taken in the normal diet. ... We propose to measure the selenium biomarkers associated with supplemental intakes of 200 or 400 µg of selenium per day in the ... selenium supplements. selenate. selenomethionine. biomarkers. plasma selenium concentration. plasma glutathione peroxidase. ...
Selenium supplements appear to slow the progress of HIV, according to interim results of a study conducted here. ... Serum selenium concentration increased significantly in the selenium-treated group but not the placebo-treated group -- an ... 83 in the placebo group and 91 in the selenium group. ... Selenium "non-responders" did not differ from the placebo group ... As a result, the "non-responders" had selenium levels and HIV responses closer to the placebo group, Dr. Hurwitz and colleagues ...
Selenium, a trace mineral found in grains, nuts and meats, and vitamin E - whether taken alone or in combination - do not ... The participants were divided into four intervention groups: selenium, vitamin E, both selenium and vitamin E, and placebos. ... slightly increased risks of prostate cancer in the vitamin E group and type two diabetes mellitus in the selenium group. Both ... Selenium, a trace mineral found in grains, nuts and meats, and vitamin E - whether taken alone or in combination - do not ...
Only 11 percent of the placebo group showed signs of hair improvement. This indicates that saw palmetto is extremely effective ... Selenium. Selenium is a nutrient necessary for many of the bodys processes. As noted in case studies, individuals with low ... Wolff Group international conference. This research is not as boundless as it might first appear. Dr. Klenk is not the first ... Together with selenium, vitamin E works to prevent cell damage and hair loss from free radical damage. ...
... the risk estimate comparing the selenium supplemented with the placebo groups was used. Risk estimates from individual studies ... Selenium supplementation of children in a selenium-deficient area in China: blood selenium levels and glutathione peroxidase ... Serum selenium and risk of large size colorectal adenomas in a geographical area with a low selenium status. Am J Gastroenterol ... Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention ...
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011;306:1549-56. ... Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to ... Vitamin E increases prostate cancer risk in middle-aged men relative to placebo: no significant association observed with ... Vitamin E increases prostate cancer risk in middle-aged men relative to placebo: no significant association observed with ...
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to ... no significant association observed with selenium, either alone or in combination with vitamin E ... Vitamin E increases prostate cancer risk in middle-aged men relative to placebo: no significant association observed with ... Copyright © 2017 by BMJ Publishing Group Ltd & RCN Publishing Company Ltd.. 京ICP备15042040号-3 ...
... and the placebo groups. Serum selenium concentrations were measured before intervention. Findings On average 145 different ... The pre-treatment expression of the microRNAs did not differ between active treatment and the placebo groups. When comparing ... Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many ... or placebo for 4 years, 25 participants from each group were randomized and evaluated regarding levels of microRNA. Isolation ...
... compared selenium (200 mcg daily for 3 months) to placebo. Those in the selenium group reported improvements in their mood and ... 1,312 people were divided into two groups. One group received 200 mcg of yeast-based selenium daily; the other received placebo ... The results over two years failed to show benefit; both the placebo and the selenium group developed precancerous and cancerous ... fewer lung cancers as compared with the placebo group. (All these results were statistically significant.) Selenium-treated ...
... receiving selenium supplementation reported significantly better wellbeing in our trial compared with the placebo group, which ... Plasma selenium values were identical in both groups at study entry (127.4 ± 15.3 g/L group A; 129.2 ± 15.1 g/L group B). In ... there was no difference in selenium tissue concentration in selenium sufficient areas . The selenium deficiency in our ... Improvement of ultrasound echogenicity was observed in all patients in group B versus ten patients in group A (. ). Evaluation ...
Selenium and Vitamin E in Preventing Cancer Progression and Recurrence in Patients With Early-Stage Bladder Cancer ... Arm II: Patients receive oral selenium tablet and oral placebo capsule once daily. - Arm III: Patients receive oral placebo ... Patients are stratified by recurrence risk group (high vs intermediate) and treatment center and randomized to 1 of 4 treatment ... Arm IV: Patients receive oral placebo tablet and oral placebo capsule once daily. In all arms, treatment continues for up to 5 ...
Two treatment groups: 60 mcg/day of selenium as selenium-enriched yeast or placebo yeast (60 mcg/day is the recommended intake ... The study will have two treatment groups: 60 mcg/day of selenium as selenium-enriched yeast or placebo (dummy) yeast (60 mcg/ ... Selenium in PRegnancy INTervention: a double-blind, randomised, placebo-controlled, two-group study ... The dose of selenium given is a nutritional dose and is the recommended intake of selenium for women. There are no risks of ...
There were 13 prostate cancer cases in the selenium-treated group and 35 cases in the placebo group (relative risk, RR=0.37, P= ... only four cases were diagnosed in the selenium-treated group and 16 cases were diagnosed in the placebo group after a 2 year ... the selenium-treated group had substantial reductions in the incidence of prostate cancer, and total cancer incidence and ... Although selenium shows no protective effects against the primary endpoint of squamous and basal cell carcinomas of the skin, ...
SELECT began in 2001 to test earlier research suggesting selenium and ...The paper which will appear in the October 12 edition ... The men were divided into four groups: vitamin E and Selenium; vitamin E alone; selenium alone; and placebo. The group taking ... The paper, which will appear in the October 12 edition of the Journal of the American Medical Association, found that a group ... The finding comes from a report summarizing the latest results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT). ...
Selenium at Portsmouth Regional Hospital Supplement Forms/Alternate Names Selenite Selenomethionine Selenized Yeast Selenium ... compared selenium (200 mcg daily for 3 months) to placebo. Those in the selenium group reported improvements in their mood and ... One group received 200 mcg of yeast-based selenium daily; the other received placebo. Participants were not deficient in ... The results over two years failed to show benefit; both the placebo and the selenium group developed precancerous and cancerous ...
A more thorough evaluation of selenium supplementation is needed, to better understand its benefits to our immune system, and ... Groups of people with marginal selenium status, aged 50-64, were given selenium supplements, at different doses, to include in ... Others were given meals containing onions enriched with selenium. Other participants were given placebos, not containing ... Selenium deficiency has for a long time been associated with an impaired immune system. People with low levels of selenium have ...
The patients were divided into 4 groups and were given either levothyroxine, selenium, levothyroxine + selenium, or placebo. ... All three treatment groups of women, including those taking levothyroxine, levothyroxine + selenium or selenium-only, had the ... The group that took levothyroxine or levothyroxine + selenium had a reduction in TSH levels and increase in thyroid hormone ... At the start of the study, all groups of the Hashimotos patients had higher inflammatory markers than the group of healthy ...
E and selenium alone; a cholesterol-lowering drug plus niacin plus antioxidants; or a placebo. After three years of this ... They were divided into four groups and given: a cholesterol-lowering drug plus the vitamin, niacin; antioxidant vitamins A,C, ... And that antioxidants are no more effective than placebo in preventing heart attacks. ... and 100 micrograms of selenium (twice the recommended dosage). ... antioxidants were no better off than those who took placebos. ...
Compared with the placebo (referent group) in which 529 men developed prostate cancer, 620 men in the vitamin E group developed ... as did 575 in the selenium group (HR, 1.09; 99% CI, 0.93-1.27; p = 0.18), and 555 in the selenium plus vitamin E group (HR, ... The primary analysis included 34,887 men who were randomly assigned to one of four treatment groups: 8,752 to receive selenium ... Selenium, Dietary Supplements, Cardiovascular Diseases, Confidence Intervals, African Continental Ancestry Group, Prostatic ...
Find patient medical information for SELENIUM on WebMD including its uses, effectiveness, side effects and safety, interactions ... a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 1998;29(1):12-17. View abstract. ... SELENIUM Uses & Effectiveness Likely Effective for:. *Selenium deficiency. Taking selenium by mouth is effective for preventing ... Selenium might thin the blood. Selenium might also increase the effects of warfarin in the body. Taking selenium along with ...
... selenium, vitamin E, selenium plus vitamin E, or placebo.15 Findings: 13 percent more prostate cancer for the vitamin E groups ... The Selenium and Vitamin E Cancer Prevention Trial (SELECT). A total of 35,533 men were assigned to one of four groups: ... Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention ... or placebo.17 Findings: There were 75% more deaths from fatal coronary artery disease in the beta-carotene groups and a slight ...
SupplementsVitamin E and seleniumForm of seleniumHigh-selenium yeastParticipantsProstateForms of seleniumPlus seleniumSelenomethionineYeastIncidenceAmount of seleniumIntake of seleniumDeficiency of seleniumSupplementMicrograms of seleniumControlled trialsNutritionally essentialGlutathione peroxidase activityBeta caroteneDosesSupplementation groupSodium SeleniteSelenoproteinTrace elementAntioxidantReceiving selenium supplementationLowest selenium levelsHighest selenium levelsSerum selenium concentrationsStatisticallySelenocysteineVitaminsEffect of seleniumNutrientsBenefit from increasing seleSignificantlyAntioxidantsGiven two placebosResearchersHumansConcentrationLevelsThyroidConcentrationsUrinary selenium excretionAssociation of serum seleniumPlasmaCancersTaking selenium and vitamin
- Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. (nih.gov)
- Neither the men nor their physicians know which supplements or placebos the men have been taking, a procedure known as blinding or masking. (nih.gov)
- They were randomly assigned to take one of four sets of supplements or placebos, with more than 8,000 men in each group. (nih.gov)
- and the final group received placebos of both supplements. (nih.gov)
- Contradicting evidence from preclinical and observational studies, a mean follow-up of almost eight years showed that the diabetes risk more than doubled in those with the highest selenium levels at baseline who took supplements, compared with those who had the lowest baseline levels. (medpagetoday.com)
- Patients randomized to selenium supplementation had a type 2 diabetes incidence of 12.6 per 1,000 person-years versus 8.4 for those not receiving nutrient supplements, Saverio Stranges, M.D., Ph.D., of Warwick Medical School and University Hospital in Coventry, and colleagues at the U.S. Department of Agriculture, reported online ahead of Aug. 21 publication in the Annals of Internal Medicine . (medpagetoday.com)
- In an editorial that accompanied the report, Eliseo Guallar, M.D., DrPH, of the Johns Hopkins Bloomberg School of Public Health, and co-authors there, pointed out that more than 1% of the U.S. population takes selenium supplements, and more than 35% take multivitamin and multi-mineral supplements that may contain it. (medpagetoday.com)
- By taking selenium supplements on top of an adequate dietary intake, people may increase their risk for diabetes. (medpagetoday.com)
- Designed primarily to assess the effects of selenium supplements on cancer risk, the trial involved 1,312 patients who were randomized to 200 Âµg/d of selenium or placebo and followed from 1983 through 1996. (medpagetoday.com)
- MIAMI -- Selenium supplements appear to slow the progress of HIV, according to interim results of a study conducted here. (medpagetoday.com)
- Point out that this study suggests that selenium supplements may safely improve the immune function of patients with HIV. (medpagetoday.com)
- MIAMI, Jan. 22 -- Selenium supplements appear to slow the progress of HIV, according to interim results of a study conducted here. (medpagetoday.com)
- This fact has given rise to a theory that selenium deficiency is a common cause of cancer, and that selenium supplements can reduce this risk. (epnet.com)
- As we will see, there is some preliminary evidence that selenium supplements might provide some protection against some types of cancer among people living in the US, but this evidence is far from definitive. (epnet.com)
- The table below from the Office of Dietary Supplements provides a more complete list of the selenium content in certain foods and the percent daily value. (epnet.com)
- The two general types of selenium supplements are available to consumers are organic and inorganic forms. (epnet.com)
- 13,14 However, other research on both animals and humans suggests that selenite supplements are about as good as organic forms of selenium. (epnet.com)
- 25-32,62 A large trial reported in 2007 reported that use of selenium supplements reduced viral load. (epnet.com)
- For reasons that are not clear, another study found that selenium supplements decreased symptoms of psychological anxiety in patients undergoing highly active retroviral therapy (HAART). (epnet.com)
- One study of healthy people in the UK (where marginally low selenium intake is common) found that use of selenium supplements improved general immune function, as measured by response to poliovirus immunization. (epnet.com)
- In this pilot study we are testing the effect of small supplements of selenium to bring the daily intake to the recommended daily intake during pregnancy. (isrctn.com)
- SELECT began in 2001 to test earlier research suggesting selenium and vitamin E supplements may reduce the risk of developing certain cancers. (bio-medicine.org)
- Some vitamin supplements containing enhanced levels of selenium and vitamin E were marketed to consumers during this time period with claims of reducing cancer risk. (bio-medicine.org)
- Groups of people with marginal selenium status, aged 50-64, were given selenium supplements, at different doses, to include in their diet. (medicalnewstoday.com)
- Nevertheless, because the results indicated that it was very unlikely that either vitamin E or selenium would provide a benefit, study participants were told to stop taking the supplements. (cancerconnect.com)
- TUESDAY, Nov. 26, 2013 (HealthDay News) -- New research from Africa suggests that basic multivitamin and selenium supplements might greatly lower the risk that untreated people with the AIDS virus will get sicker over a two-year period. (medicinenet.com)
- Another group took the multivitamin along with supplements of the mineral selenium, and still others took only selenium. (medicinenet.com)
- The selenium supplements, in particular, may provide enough of the mineral that the virus isn't able to hog it, she said. (medicinenet.com)
- Intervention trials with different forms of selenium are under way to assess the effects of selenium supplements on the incidence of cancer and other diseases. (nih.gov)
- Moderate (approximately 200 microg/d) to large (approximately 600 microg/d) selenium supplements in the forms sodium selenite, high-selenium yeast (yeast), and l-selenomethionine (selenomethionine) were administered. (nih.gov)
- There is no evidence that selenium supplements reduce side effects of chemotherapy, radiotherapy or the effects of surgery in cancer patients. (cochrane.org)
- Selenium supplements are frequently used by cancer patients. (cochrane.org)
- Taking daily selenium supplements appears to increase the level of the essential mineral in the blood and may suppress the progression of viral load in patients with HIV infection, according to an article in the January 22 issue of Archives of Internal Medicine. (infectioncontroltoday.com)
- Selenium deficiencies have been observed in patients with HIV spectrum disease and evidence suggests that selenium supplements can improve immune functioning. (infectioncontroltoday.com)
- Barry E. Hurwitz, PhD, of the University of Miami, and colleagues conducted a double-blind, randomized, placebo-controlled trial of selenium supplements in 262 patients with HIV. (infectioncontroltoday.com)
- Supplements of selenium may reduce markers of oxidative stress immediately after exercise for overweight people, suggests a new study. (drjeffreytucker.com)
- Results showed that selenium supplements were associated with a 0.25 micromole per liter decrease in lipid hydroperoxides levels, compared to placebo, in the overweight participants immediately following exercise. (drjeffreytucker.com)
- Review details Bjelakovic and collaborators from the University of Nis in Serbia, and Ospedale V. Cervello in Palermo, followed the Cochrane Collaboration method for meta-analysis and systematically reviewed 67 randomised clinical trials including 232,550 participants, and focusing on beta-carotene, vitamin A, vitamin C, vitamin E, and selenium supplements versus placebo. (nutraingredients-usa.com)
- Bjelakovic and co-workers report no reduction in mortality, and note that 13.1 per cent of the participants randomised to antioxidant supplements died, compared to 10.5 per cent randomised to placebo or no intervention. (nutraingredients-usa.com)
- We conducted a randomized placebo-controlled study of high-selenium yeast, the form used in most supplements (300 μg/day, 3.8 μmol/day), administered to 42 free-living healthy men for 48 weeks. (springer.com)
- The Selenium and Vitamin E Cancer Prevention Trial, or SELECT, seeks to learn if these two dietary supplements can protect against prostate cancer, which in men is the most common form of cancer after skin cancer. (uthscsa.edu)
- Men in the study who took supplements of 400 international units (IU) of vitamin E every day were 17 percent more likely to develop prostate cancer over a seven-year period than men who took a placebo pill, the researchers said. (livescience.com)
- The study, started in 2001, was intended to see whether supplements of vitamin E or selenium reduced men's risk of prostate cancer. (livescience.com)
- Men were randomly assigned to one of four groups: One group took both selenium and vitamin E, one took selenium and a placebo, one took vitamin E and a placebo and the final group took placebos of both supplements. (livescience.com)
- Evidence from two systematic reviews of randomised controlled trials does not support the use of selenium supplements for cancer prevention in populations with an adequate baseline selenium status. (cam-cancer.org)
- Inorganic forms (e.g. sodium selenite or selenate) and organic forms (e.g., selenomethionine) are both used in large numbers of selenium-containing medications, nutritional supplements or dietary aids that are promoted for medical or health purposes. (cam-cancer.org)
- These may contain either selenium alone (mono-supplements) or selenium in combination with other trace minerals as well as vitamins. (cam-cancer.org)
- Two recent systematic reviews have evaluated the preventive efficacy of selenium mono-supplements for cancer. (cam-cancer.org)
- In addition, a large number of selenium-containing nutritional supplements or dietary aids are marketed for medical or health purposes. (cam-cancer.org)
- Chronic selenium poisoning (selenosis) has been seen in seleniferous areas of North America and China, but has also been attributed to commercially available selenium supplements. (cam-cancer.org)
- The EU Scientific Committee on Food considers an upper selenium limit (for adults) of 300µg/day (including supplements) to be acceptable for the avoidance of selenosis. (cam-cancer.org)
- No controlled data are available on the effects of selenium supplements in non-selenium-deficient women during pregnancy or lactation. (cam-cancer.org)
- Scientists from Linköping University in Sweden studied 443 healthy elderly participants consuming either placebo or supplements of CoQ10 (200 mg/day) plus selenium (200 micrograms/day) for four years. (nutraingredients.com)
- One group received glycosaminoglycans (GAG), which include glucosamine or chondroitin sulfate, together with the supplements vitamin E and selenium. (secondopinionnewsletter.com)
- Supplements like Advanced Joint Support from Advanced Bionutritionals, along with a good multivitamin that includes both vitamin E and selenium (such as Healthy Resolve, also from Advanced Bionutritionals), can go a long way toward rebuilding your joint compounds. (secondopinionnewsletter.com)
- What is the long-term effect of vitamin E and selenium on risk of prostate cancer in relatively healthy men? (acc.org)
- Prostate cancer risk did not increase when vitamin E and selenium were taken together. (naturalmedicinejournal.com)
- SELECT is the first study designed to look directly at the effects of vitamin E and selenium, both separately and together, in preventing prostate cancer," said Dr. Joseph W. Basler, associate professor of surgery at the Health Science Center and the principal investigator for the San Antonio portion of the study. (uthscsa.edu)
- Previous research involving vitamin E and selenium suggested that these nutrients might prevent prostate cancer, but we don't know for sure. (uthscsa.edu)
- Men who took selenium alone, or vitamin E and selenium together, were also more likely to develop prostate cancer than men who took a placebo, but these increases were small and possibly due to chance. (livescience.com)
- Since recruitment began in 2001, three ancillary studies have been added that will investigate the effects of vitamin E and selenium on other health issues in the SELECT participants, Goodman said. (fredhutch.org)
- One study led by researchers at the University of Kentucky, which will involve 5,000 of the SELECT participants, seeks to determine whether vitamin E and selenium can reduce the incidence of Alzheimer's disease. (fredhutch.org)
- A second study led by investigators at Harvard Medical School will assess whether vitamin E and selenium can reduce the risk of visually significant macular degeneration and cataracts, two conditions that can lead to vision loss. (fredhutch.org)
- The third ancillary study, led by Cornell University, will examine the role of vitamin E and selenium in chronic obstructive pulmonary disease, a smoking-related disease in which lung function is decreased. (fredhutch.org)
- A fourth study-due to be launched by researchers at the University of Arizona-will investigate whether vitamin E and selenium can reduce the risk of benign colorectal tumors known as adenomas, which can lead to cancer. (fredhutch.org)
- There was no increased incidence of prostate cancer when vitamin E and selenium were taken together. (nih.gov)
- It is possible that certain diseases result in selenium deficiency because of the form of selenium taken in the normal diet. (clinicaltrials.gov)
- The inorganic form of selenium, selenite, is essentially selenium atoms bound to oxygen. (epnet.com)
- Subjects were randomized into 10 groups (placebo and three dose levels of each form of selenium). (nih.gov)
- Julian Whitaker, M.D. reports, "The best absorbed form of selenium, and the one used by Dr. Clark"s research, is high-selenium yeast" . (theherbprof.com)
- The food form of selenium is selenocysteine. (theherbprof.com)
- Why selenocysteine food form Selenium and not some other form of Selenium. (theherbprof.com)
- In one trial, supplementing with sodium selenite (a form of selenium) improved symptoms in some patients. (peacehealth.org)
- In a small double-blind trial, supplementation with 100 mcg of sodium selenite (a form of selenium) per day for 14 weeks resulted in clinical improvement in six of eleven patients, compared with only one of ten in the placebo group. (peacehealth.org)
- The bioavailability of ingested organic and inorganic selenium - as a function of absorption, metabolism and excretion - is reported to be between 50% and 90%, depending on the form of selenium and type of preparation, as well as on age, physiological status and polymorphisms in selenium transport protein genes. (cam-cancer.org)
- Some research suggests that selenite is harder for the body to absorb than organic forms of selenium, such as selenomethionine (selenium bound to methionine, an essential amino acid) or high-selenium yeast (which contains selenomethionine). (epnet.com)
- Response of selenium status indicators to supplementation of healthy North American men with high-selenium yeast. (nih.gov)
- The Selenium used was high selenium yeast called Selenomax. (theherbprof.com)
- 141 took a capsule containing 200 micrograms of high-selenium yeast and 121 took a similar capsule containing inactive yeast and a filler material. (infectioncontroltoday.com)
- Investigators intend to follow the participants for about three years to determine the long-term effects of having taken either supplement or placebo and to complete a biorepository of blood samples that will be used in extensive molecular analyses to give researchers a better understanding of prostate cancer, other cancers, and other diseases of male aging. (nih.gov)
- The participants were divided into four intervention groups: selenium, vitamin E, both selenium and vitamin E, and placebos. (thaindian.com)
- After treatement for 4 weeks, all participants will receive 400 µg of selenium per day as selenate for 4 weeks. (clinicaltrials.gov)
- Other participants were given placebos , not containing selenium, and neither the participants nor the scientists knew which were supplemented until after the study. (medicalnewstoday.com)
- The selected participants will be randomly assigned in equal numbers to the experimental or control group. (clinicaltrials.gov)
- Participants in the experimental group will be given 1 serving (10g) of Cardioflex each day. (clinicaltrials.gov)
- Participants in the control group will be given a flavored 10g placebo that looks and tastes exactly like Cardioflex. (clinicaltrials.gov)
- The clinical trial is double blinded so neither the participants or investigators will know which experimental group they are in until the data collection period is over. (clinicaltrials.gov)
- Participants received a daily dose of 200 mcg of selenium for three weeks or three weeks of placebo. (drjeffreytucker.com)
- Commenting on the discrepancy between the overweight and normal weight participants, the researchers note that selenium plays a crucial role in the body's antioxidant defenses, particularly in antioxidant enzymes, such as glutathione (GSH). (drjeffreytucker.com)
- The researchers note that the overweight participants had low selenium levels at the start of the study and this may be why they expressed a "compromised antioxidant system and raised lipid hydroperoxides levels at rest and after high-intensity exercise. (drjeffreytucker.com)
- For the study, researchers evaluated the plasma selenium levels of 446 elderly participants living in these areas of notable longevity in China. (lifeextension.com)
- By 2011, nine randomized controlled clinical trials including 152,538 participants established that selenium supplementation cut risk for all cancers by 24% . (lifeextension.com)
- The study began in 2001 and broke participants into four groups: one would receive selenium, another would get 400 international units of daily vitamin E, another group would take both, and the fourth was prescribed a placebo. (medindia.net)
- The fact that the increased risk of prostate cancer in the vitamin E group of participants in SELECT was only apparent after extended follow-up. (medindia.net)
- In intent-to-treat analysis, participants receiving the combined supplement of multivitamins plus selenium had a significantly lower risk vs placebo of reaching CD4 cell count 250/μL or less. (nutraceuticalsworld.com)
- The participants were split into two groups and instructed to take a daily pill for the next eight years. (motherearthliving.com)
- Researchers will monitor the number of prostate-cancer cases that develop among the participants to assess whether vitamin E and/or selenium are associated with a difference in prostate-cancer incidence. (fredhutch.org)
- Early signs of selenium toxicity (garlic breath, hair and nail changes, upset stomach) were observed in participants of a clinical trial who received 1600µg or 3200µg selenised yeast/day for up to 24 months. (cam-cancer.org)
- 24 In the Selenium and Vitamin E Cancer Prevention Trial, 25 which used 200µg/day selenomethionine for 7-12 years, the rate of alopecia (overall incidence: 3% of participants) and mild dermatitis (7% of participants) was higher than in the placebo group (relative risk increase: +28% and +17%, respectively). (cam-cancer.org)
- The group included in the this analysis consisted of 834 men who had been diagnosed with incident, primary prostate cancers (156 were high-grade cancer) along with a comparison group of 1,393 men selected randomly from the 35,500 participants in SELECT. (scienceblog.com)
- Participants were randomly divided into two groups and received 2 ounces of Vemma or placebo each morning for 30 days. (vemma.com)
- Participants were separated into two groups, placebo and the Vemma product. (vemma.com)
- Then, participants either received a single dose of the Vemma product or placebo. (vemma.com)
- Participants were randomized to receive either 200 micrograms of selenium or placebo. (innovations-report.com)
- In total, 3.66 percent of participants in the selenium arm developed a secondary primary tumor of any type after one year, compared to 4.1 percent in the placebo group. (innovations-report.com)
- reported a positive association between serum selenium concentrations and the prevalence of diabetes among participants in the Third National Health and Nutrition Examination Survey (NHANES III). (pubmedcentralcanada.ca)
- In the SELECT study, researchers randomly assigned participants into four treatment groups to receive daily doses of selenium (200 micrograms), vitamin E (400 international units [IU]), both selenium and vitamin E, or placebo. (nih.gov)
- citation needed] Pharma Nord's selenium dietary supplement SelenoPrecise is currently used in the Prevention of Cancer by Intervention with Selenium (PRECISE) study, a population study involving 40,000 test participants from Denmark, Sweden and England. (wikipedia.org)
- The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E and a small, but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium. (nih.gov)
- Washington, Dec 10 (ANI): Selenium, a trace mineral found in grains, nuts and meats, and vitamin E whether taken alone or in combination do not prevent prostate cancer, according to a new study. (thaindian.com)
- The team led by scientists at The University of Texas M. D. Anderson Cancer Centre and Cleveland Clinic has shown that selenium and vitamin E showed no benefits for prostate cancer patients. (thaindian.com)
- However, the data showed two statistically non-significant findings of concern: slightly increased risks of prostate cancer in the vitamin E group and type two diabetes mellitus in the selenium group. (thaindian.com)
- Doing so is critical not only to determine any possible long-term effects of the selenium and vitamin E, but also in order to gain a better understanding of prostate and other cancers and age-related disease," he added. (thaindian.com)
- Within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we reported that serum selenium was inversely associated with colorectal adenoma risk only in men, but not in women ( 1 ). (aacrjournals.org)
- Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). (bmj.com)
- The paper, which will appear in the October 12 edition of the Journal of the American Medical Association , found that a group of men taking a daily dose of 400 IU of vitamin E from 2001 to 2008 had 17 percent more cases of prostate cancer than men who took a placebo. (bio-medicine.org)
- The group taking vitamin E was the only group shown to have a statistically significant increased risk of prostate cancer. (bio-medicine.org)
- Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. (nih.gov)
- To test if supplemental dietary selenium is associated with changes in the incidence of prostate cancer. (nih.gov)
- Selenium treatment was associated with a significant (63%) reduction in the secondary endpoint of prostate cancer incidence during 1983-93. (nih.gov)
- There were 13 prostate cancer cases in the selenium-treated group and 35 cases in the placebo group (relative risk, RR=0.37, P=0.002). (nih.gov)
- Although selenium shows no protective effects against the primary endpoint of squamous and basal cell carcinomas of the skin, the selenium-treated group had substantial reductions in the incidence of prostate cancer, and total cancer incidence and mortality that demand further evaluation in well-controlled prevention trials. (nih.gov)
- Compared with placebo, the absolute increase in risk of prostate cancer per 1,000 person-years was 1.6 for vitamin E, 0.8 for selenium, and 0.4 for the combination. (acc.org)
- There is a great deal of interest in the relationship between diet and cancer, and some previous studies suggested that selenium and vitamin E may reduce the risk of certain types of cancer, including prostate cancer. (cancerconnect.com)
- To further explore the relationship between selenium and vitamin E supplementation and risk of prostate cancer, researchers conducted a randomized trial known as SELECT (the Selenium and Vitamin E Cancer Prevention Trial). (cancerconnect.com)
- Men in the placebo group had the fewest prostate cancers. (cancerconnect.com)
- Prostate cancer was diagnosed in 529 men in the placebo group, 620 men in the vitamin E group, 575 men in the selenium group, and 555 men in the selenium plus vitamin D group. (cancerconnect.com)
- Men in the vitamin E group were 17% more likely than men in the placebo group to be diagnosed with prostate cancer. (cancerconnect.com)
- Effect of selenium and vitamin E on risk of prostate cancer and other cancers. (cancerconnect.com)
- The selenium supplemented group had 63% fewer cancers of the prostate, 58% less cancer of the colon, and 46% less lung cancers then the placebo group. (theherbprof.com)
- Prostate Cancer-"Selenium may reduce the risk of prostate cancer. (wholefoodsmagazine.com)
- Based on its review, FDA does not agree that selenium may reduce the risk of prostate cancer. (wholefoodsmagazine.com)
- Certain Cancers Claim and Anticarcinogenic Effects Claim-"Selenium may reduce the risk of bladder, colon, prostate, and thyroid cancers. (wholefoodsmagazine.com)
- Do selenium and vitamin E really increase the risk of prostate cancer? (naturalmedicinejournal.com)
- The rate of prostate cancer detection was greater in all treatment groups when compared with placebo but was statistically significant only in the vitamin E alone group. (naturalmedicinejournal.com)
- 3 In addition to the finding that higher levels of gamma-tocopherol significantly reduced prostate cancer risk, the study also showed that selenium and alpha-tocopherol reduced prostate cancer incidence, but only when gamma-tocopherol levels are high. (naturalmedicinejournal.com)
- The Health Report website also shows that selenium is kind to your prostate, if you happen to have one. (abc.net.au)
- I organise a number of MSc Nutritional Medicine modules and lecture not just on selenium and iodine, but also on the like between diet and pre-eclampsia, osteoarthritis, prostate cancer and dementia. (surrey.ac.uk)
- It is suspected that selenium is protective against prostate cancer. (aacrjournals.org)
- Odds ratios for prostate cancer, based on quartiles of serum selenium levels, were determined using the General Estimating Equations approach. (aacrjournals.org)
- After a 7-year observation period, the researchers found that high selenium levels in toenails were associated with a reduced risk of advanced prostate cancer in 181 patients. (aacrjournals.org)
- The purpose of the present study was to further investigate the relation of serum selenium levels to prostate cancer risk. (aacrjournals.org)
- In a study of selenium to prevent one type of non-melanoma skin cancer in 1,000 men and women, reported in 1996, investigators found that while the supplement did not reduce skin cancer, it did decrease the incidence of prostate cancer in men by more than 60 percent. (uthscsa.edu)
- As early as 1996, selenium supplementation was shown to lower overall cancer rates, and to specifically reduce rates of lung, colorectal, and prostate cancers. (lifeextension.com)
- 28 Studies also show that adequate dietary selenium exerts powerful preventive effects on prostate and colorectal cancer, two of the most common malignancies. (lifeextension.com)
- Ten years after the start of a randomized trial of more than 35,000 men, researchers discovered the spike in prostate cancer among those assigned to take vitamin E rather than selenium or a placebo. (medindia.net)
- The study was launched based on previous research that had suggested that selenium or vitamin E might reduce the risk of developing prostate cancer. (medindia.net)
- A total of 620 men in the vitamin E group developed prostate cancer, as did 555 in the combined selenium and vitamin E group. (medindia.net)
- Those taking selenium only saw 575 develop prostate cancer, compared to 529 on the sugar pill. (medindia.net)
- Phyllis Goodman holds selenium and Vitamin E, two nutrients being tested for their potential to prevent prostate cancer. (fredhutch.org)
- More than 35,500 men have volunteered to take part in the largest-ever prostate-cancer prevention study, known as the Selenium and Vitamin E Cancer Prevention Trial (SELECT), in which the center plays a key role. (fredhutch.org)
- The study seeks to determine whether vitamin E and the trace element selenium can protect against prostate cancer, the most common form of malignancy in men excluding non-melanoma skin cancer. (fredhutch.org)
- The current study analyzed data and specimens collected from men who participated in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a large randomized, placebo-controlled trial to test whether selenium and vitamin E, either alone or combined, reduced prostate cancer risk. (scienceblog.com)
- That study showed no benefit from selenium intake and an increase in prostate cancers in men who took vitamin E. (scienceblog.com)
- Editor's note: Please contact Kristen Woodward, Fred Hutch media relations, to schedule interviews and to obtain an embargoed copy of the paper, "Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the Selenium and Vitamin E Cancer Prevention Trial. (scienceblog.com)
- Interest and research escalated in the late 1990's after a skin cancer and selenium study, published in 1996, found no benefit against the skin cancer, but did suggest an approximate 30 percent reduction of prostate and lung cancers. (innovations-report.com)
- In 2009, the National Cancer Institute (NCI) halted SELECT, an international study of more than 35,000 men investigating if either selenium or Vitamin E, alone or in combination, could reduce the risk of prostate cancer. (innovations-report.com)
- There was an onslaught of misinformation generated by the media when the National Cancer Institute's (NCI) Selenium and Vitamin E Cancer Prevention Trial (SELECT), a study of the role of selenium in prostate cancer, was halted in October 2008. (wholefoodsmagazine.com)
- The initial study report stated that selenium and vitamin E taken alone or together did not prevent prostate cancer. (nih.gov)
- At a median followup of 7 years, the researchers observed that the incidence of prostate cancer was increased by 17 percent in men who received the vitamin E supplement alone compared with those who received placebo. (nih.gov)
- The researchers noted that a biological explanation for the increased incidence of prostate cancer in the vitamin E group was not apparent from these data, but that the increased incidence became evident only after a longer period of monitoring. (nih.gov)
- The effect of supplementation with two chemical forms of selenium on plasma selenium biomarkers will be determined and correlated with the severity of the liver disease. (clinicaltrials.gov)
- The study also showed that different forms of selenium have different effects on the production of cytokines, which are molecules that play an important role in coordinating the immune system. (medicalnewstoday.com)
- By protecting DNA, eliminating toxins, boosting immunity, and optimizing thyroid function, the proper forms of selenium have been shown to impede heart disease, certain cancers, immune senescence, and premature death. (lifeextension.com)
- Although this study was small, it helped demonstrate that patients with Hashimoto's disease might benefit from being treated with a combination of thyroid hormone plus selenium, even before their thyroid tests indicate hypothyroidism. (wilsonssyndrome.com)
- Only the combination of vitamins plus selenium was effective," Baeten said. (medicinenet.com)
- Supplementation with vitamins B, C and E plus selenium significantly slowed the rate of HIV disease progression. (aidsmap.com)
- Multivitamins plus selenium. (aidsmap.com)
- Compared to people in the placebo arm, individuals who received multivitamins alone or multivitamins plus selenium were significantly less likely to experience a fall in their CD4 cell count to below 250 cells/mm 3 (p = 0.04 and p = 0.02, respectively). (aidsmap.com)
- Multivitamins plus selenium in a single supplement, vs placebo, also reduced the risk of secondary events of combined outcomes for disease progression. (nutraceuticalsworld.com)
- We propose to measure the selenium biomarkers associated with supplemental intakes of 200 or 400 µg of selenium per day in the chemical form selenate, or with supplemental intake of 200 µg selenium as selenomethionine. (clinicaltrials.gov)
- Supplementation with selenomethionine and yeast raised the plasma selenium concentration in a dose-dependent manner. (nih.gov)
- The increased selenium concentration correlated with the amount of selenomethionine administered. (nih.gov)
- Urinary selenium excretion was greater after selenomethionine than after selenite, with excretion after yeast being intermediate and not significantly different from either of the other two. (nih.gov)
- We conclude that plasma selenium concentration is useful in monitoring compliance and safety of selenium supplementation as selenomethionine but not as selenite. (nih.gov)
- Plasma selenium seems to reflect the selenomethionine content of yeast but not the other yeast selenium forms. (nih.gov)
- As judged by urinary selenium excretion, selenium in the form of selenomethionine is better absorbed than selenite. (nih.gov)
- Men were randomized into 1 of 4 groups: selenium (200 μg/d from L-selenomethionine) and a vitamin E placebo, vitamin E (400 IU/d of all rac-α-tocopherol acetate) and a selenium placebo, selenium plus vitamin E, or placebo. (naturalmedicinejournal.com)
- Selenium exists in two forms: inorganic (selenate and selenite) and organic (selenomethionine and selenocysteine) [ 2 ]. (nih.gov)
- Most selenium is in the form of selenomethionine in animal and human tissues, where it can be incorporated nonspecifically with the amino acid methionine in body proteins. (nih.gov)
- Selenium occurs naturally in a number of inorganic forms (e.g. selenite, selenate, selenide) and is also found in organic compounds (e.g. selenomethionine, selenocysteine). (cam-cancer.org)
- Additional selenium intake at high intake levels does not increase glutathione peroxidase synthesis or activity, but rather increases plasma selenium concentration by the non-specific incorporation of selenomethionine into plasma proteins ( Institute of Medicine and Panel on Dietary Antioxidants and Related Compounds 2000 ), with unknown health effects. (pubmedcentralcanada.ca)
- Most selenium content in this nut is present in protein fractions;therefore, the cake protein has the highest amount of selenium presented as selenomethionine and selenocysteine [ 15 ]. (biomedcentral.com)
- Those in the selenium group received 200 mcg/day of the metal, in a high-yield yeast formulation. (medpagetoday.com)
- The study will have two treatment groups: 60 mcg/day of selenium as selenium-enriched yeast or placebo (dummy) yeast (60 mcg/day is the recommended intake for UK pregnant women). (isrctn.com)
- Furthermore, Larry Clark, Ph.D. and others have found that selenium in yeast appears to reduce risk of certain cancers . (theherbprof.com)
- Yes it's L-selenium methionine but it is an organic form, it's grown in yeast. (abc.net.au)
- The absorption, distribution, and excretion of selenium from high-Se yeast were similar to selenium in foods. (springer.com)
- The strongest evidence supporting the anticancer effects of selenium supplementation comes from a double-blind trial of 1,312 Americans with a history of skin cancer who were treated with 200 mcg of yeast-based selenium per day or placebo for 4.5 years, then followed for an additional two years. (peacehealth.org)
- Fermentation of yeast in a medium that is rich in inorganic selenium yields selenised yeast which contains 80-90% organic forms such as selenomethione, Se-methylselenocysteine and γ-glutamyl-Se-methylselenocysteine. (cam-cancer.org)
- Diabetes incidence was consistently, though not significantly, higher in the selenium group within all subgroups examined. (medpagetoday.com)
- However, in some parts of China where the soil is depleted of selenium, the incidence of various types of cancer is much higher than in the rest of the country. (epnet.com)
- In regions with severe selenium deficiency, there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. (hindawi.com)
- If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk. (unboundmedicine.com)
- Based on what was known about the age-specific rates of lung cancer among Finnish men, study designers calculated that the desired effect size (a hoped-for 25% decrease in cancer incidence over a period of 6 years) would be measurable with the required level of statistical relevance if 18,000 older male smokers made up the study group. (bigthink.com)
- Low soil levels of selenium, probably associated with low dietary intake, have been associated with increased cancer incidence in humans. (peacehealth.org)
- Reported adverse events were adjudicated as unlikely to be related to the intervention, and there were no notable differences in incidence of HIV-related and health-related events among study groups. (nutraceuticalsworld.com)
- In the United Kingdom, where the age standardised incidence and mortality is the highest in the world, the incidence among women aged 50 approaches two per 1000 women per year, and the disease is the single commonest cause of death among women aged 40-50, accounting for about a fifth of all deaths in this age group. (slideshare.net)
- There are more than 14 000 deaths each year, and the incidence is increasing particularly among women aged 50-64, probably because of breast screening in this age group. (slideshare.net)
- In the UK, the amount of selenium in the diet has been dropping over recent years, in part due to a switch away from flour imported from North America, which is naturally higher in selenium than European wheats. (medicalnewstoday.com)
- The amount of selenium in food depends on where it is grown or raised. (webmd.com)
- The amount of selenium in soils varies a lot around the world, which means that the foods grown in these soils also have differing selenium levels. (webmd.com)
- Although this amount of selenium is adequate, it is below the average daily intake in the U.S., which is 125 mcg. (webmd.com)
- The amount of selenium in drinking water is not nutritionally significant in most geographic regions [ 2 , 6 ]. (nih.gov)
- The amount of selenium in a given type of plant-based food depends on the amount of selenium in the soil and several other factors, such as soil pH, amount of organic matter in the soil, and whether the selenium is in a form that is amenable to plant uptake [ 2 , 6 , 8 , 9 ]. (nih.gov)
- The thyroid gland contains the highest amount of selenium [ 10 ], and selenoprotein glutathione peroxidase can protect the thyroid gland from the oxidative damage produced during thyroid hormone synthesis [ 12 ]. (biomedcentral.com)
- The dose of selenium given is a nutritional dose and is the recommended intake of selenium for women. (isrctn.com)
- A recent study in England (see Lancet, vol 365, number 9225, 15th July 2000) found that there is a relationship between a number of health problems and low dietary intake of Selenium. (theherbprof.com)
- Less than optimal intake of selenium may have adverse effects on psychological function, even in the absence of signs of frank selenium deficiency. (peacehealth.org)
- For infants from birth to 12 months, the FNB established an AI for selenium that is equivalent to the mean intake of selenium in healthy, breastfed infants. (nih.gov)
- Because published literature suggests an association between a relative deficiency of selenium and diabetes, the investigators examined diabetes risk by baseline plasma selenium level. (medpagetoday.com)
- Selenium is a trace mineral, and it is thought that deficiency of selenium may play some role in the development of asthma. (cochrane.org)
- Several epidemiological and animal studies have long-suggested a link between deficiency of selenium and cancer development," said Karp, the study's principal investigator. (innovations-report.com)
- A total of 974 men with a history of either a basal cell or squamous cell carcinoma were randomized to either a daily supplement of 200 microg of selenium or a placebo. (nih.gov)
- The antioxidant supplement story continues to evolve with no evidence of benefit for cancer or cardiovascular disease risk reduction from beta carotene, folate, vitamin E, selenium, or vitamin C, and increased risk of lung cancer with high-dose beta carotene and risk of polyps with high-dose folate. (acc.org)
- Some research shows that taking a 100-200 mcg of a specific selenium supplement (SelenoPrecise, Pharma Nord, Denmark) daily for 6 months can modestly reduce cholesterol levels. (webmd.com)
- Some doctors recommend that people with atherosclerosis supplement with selenium, which has been shown in one study to help reduce the risk of death from heart disease. (peacehealth.org)
- Some doctors recommend that people with atherosclerosis supplement with 100-200 mcg of selenium per day. (peacehealth.org)
- A single supplement providing the combination of multivitamins with B vitamins, vitamins C and E, and selenium, as compared with placebo, administered early in HIV disease, reduced the risk of reaching a CD4 cell count of 250 cell/mm 3 or less in two years," write the authors. (aidsmap.com)
- Selenium is a trace element that is naturally present in many foods, added to others, and available as a dietary supplement. (nih.gov)
- Researchers concluded that in ART-naive HIV-infected adults, 24-month supplementation with a single supplement containing multivitamins and selenium was safe and significantly reduced the risk of immune decline and morbidity. (nutraceuticalsworld.com)
- Dietay supplement fact sheet: Selenium. (cam-cancer.org)
- They gave 60 women aged 35-60 an oral dietary supplement containing antioxidants (coenzyme Q10, beta-carotene, grape seed extract, French maritime pine bark extract, green tea extract, and D-alpha-tocopheryl acetate), minerals (zinc and selenium), and glycosaminoglycans, or a placebo once daily for 12 weeks. (ift.org)
- Selenium, a supplement taken daily by millions in hopes of protection against cancer and a host of other diseases, has proven to be of no benefit in reducing a patient's risk of developing lung cancer - either a recurrence or second primary malignancy, according to results of an international Phase III clinical trial. (innovations-report.com)
- Side effects were minimal and no different in both groups: of those taking placebo, 38 percent had grade 1 or 2 toxicity, and 3 percent had grade 3, compared to 39 percent and 1 percent, respectively in those taking the supplement. (innovations-report.com)
- One really needs enormous long-term, double-blind, placebo-controlled studies in which some people are given the supplement while others are given placebo. (stdavids.com)
- Pharma Nord was founded in 1981 by the two current owners, Eli Wallin and Sven Moesgaard, who established an import of a British selenium dietary supplement. (wikipedia.org)
- In this study, heart attack risk was increased by taking 800 international units of vitamin E (double the recommendation), 1000 mg of vitamin C (ten times the recommended dose), 25 mg of natural beta carotenes that forms vitamin A in your body (4 times the recommended amount) and 100 micrograms of selenium (twice the recommended dosage). (drmirkin.com)
- One group will take 200 micrograms of selenium daily plus an inactive capsule, or placebo, that looks like vitamin E. Another group will take 400 milligrams of vitamin E daily along with a placebo that looks like selenium. (uthscsa.edu)
- In the absence of placebo-controlled trials to evaluate the long-term effects of selenium on type 2 diabetes risk, the investigators examined data from the Nutritional Prevention of Cancer Trial. (medpagetoday.com)
- In controlled trials of selenium, typical dosages were 100 mcg to 200 mcg daily. (epnet.com)
- The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. (nih.gov)
- Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. (nih.gov)
- Her research, which includes a number of randomised controlled trials, centres on the importance of trace elements to human health with particular emphasis on selenium and iodine in populations with marginal selenium or iodine deficiency. (surrey.ac.uk)
- Selenium is a nutritionally essential trace element with anticarcinogenic properties. (aacrjournals.org)
- This pioneering discovery led to the classification of selenium as nutritionally essential . (lifeextension.com)
- Selenium, which is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection [ 1 ]. (nih.gov)
- The National Institute of Health's Selenium Fact Sheet for Health Professionals also states that, "Selenium, which is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection. (mineralresourcesint.com)
- Selenium is nutritionally essential for human health. (cam-cancer.org)
- The trace element selenium (Se) is nutritionally essential for human health and is naturally present in various food groups including grains, pulses, meat and fish. (cam-cancer.org)
- Plasma biomarkers (selenium concentration, selenoprotein P concentration, and glutathione peroxidase activity) were determined before supplementation and every 4 weeks for 16 weeks. (nih.gov)
- Neither glutathione peroxidase activity nor selenoprotein P concentration responded to selenium supplementation. (nih.gov)
- Platelets were the only blood component in which glutathione peroxidase activity was significantly related to selenium content. (springer.com)
- The findings of our review show that if anything, people in trial groups given the antioxidants beta-carotene, vitamin A, and vitamin E showed increased rates of mortality. (nutraingredients-usa.com)
- Enrollees were randomized into one of four equal-sized groups, receiving either 50 mg/day (about 6 times the RDA) of alpha-tocopherol, or 20 mg/day of beta-carotene (equivalent to around 3 times the RDA of Vitamin A), or AT and BC together, or placebo only. (bigthink.com)
- Usage of selenium and beta-carotene and incident melanoma was extracted from the VITAL cohort in 2008. (naturalmedicinejournal.com)
- In a randomized, placebo-controlled, double-blind trial, daily doses of selenium substantially increased serum levels of the metal and prevented increases in HIV viral load, found Barry Hurwitz, Ph.D., of the University of Miami. (medpagetoday.com)
- Randomized controlled parallel group trials comparing selenium supplementation in doses greater than daily requirement to placebo on the outcome of mortality in patients with sepsis syndrome. (nih.gov)
- In patients with sepsis, selenium supplementation at doses higher than daily requirement may reduce mortality. (nih.gov)
- Keep in mind that selenium it is a trace element, which means that large doses are not advisable because of long-term side effects from taking too much. (mineralresourcesint.com)
- As mentioned in the RDA section of this article, it is important to note that selenium is a trace element and mega doses are not advisable. (mineralresourcesint.com)
- Selenium is toxic in high doses and might have adverse effects when taken at supranutritional doses for longer periods of time. (cam-cancer.org)
- Although a number of health problems have been linked to selenium deficiency, selenium is also toxic in large doses. (cam-cancer.org)
- Selenium, selenoprotein P and glutathione peroxidase will be measured in the plasma. (clinicaltrials.gov)
- Selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR), and selenoprotein P (SePP) contain molecular selenium in form of selenocysteines within their active center. (unboundmedicine.com)
- Quantification of one or more selenoproteins (such as glutathione peroxidase and selenoprotein P) is also used as a functional measure of selenium status [ 3 ]. (nih.gov)
- Plasma or serum selenium concentrations of 8 micrograms (mcg)/dL or higher in healthy people typically meet needs for selenoprotein synthesis [ 5 ]. (nih.gov)
- Selenium is an essential trace element and is involved in antioxidant protection and the redox-regulation in humans. (cochrane.org)
- Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. (mdpi.com)
- The trace element turned out to be selenium . (lifeextension.com)
- The trace element selenium is a nutrient essential to human health and occurs naturally in a variety of foods. (cam-cancer.org)
- An estimated 99% of the U.S. population has plasma selenium levels that are more than 95 ng/mL, although selenium-driven antioxidant activity plateaus at plasma selenium levels of 70 to 90 ng/mL. (medpagetoday.com)
- As a result, selenium supplementation would be unlikely to increase antioxidant activity. (medpagetoday.com)
- One possibility is that selenium -- an antioxidant -- may repair damage done to immune cells by reactive oxygen species, which are higher in people with HIV. (medpagetoday.com)
- Selenium is hypothesized to reduce cancer risk due to its antioxidant activity, which is mediated through selenoenzymes ( 23 ). (aacrjournals.org)
- Selenium is an essential macronutrient, and is considered to be an antioxidant. (drjeffreytucker.com)
- On the other hand, vitamin C did not have an effect on mortality and the antioxidant mineral selenium was associated with a nine per cent decrease in all-cause mortality. (nutraingredients-usa.com)
- Selenium helps regulate hormones involved in thyroid function, but, most importantly, it has antioxidant activity . (mineralresourcesint.com)
- The antioxidant amounts indicated show how Vemma is highly bioavailable and antioxidant rich compared to the placebo. (vemma.com)
- Vitamin E' is the collective name for a group of fat-soluble compounds with distinctive antioxidant activities [ 1 ]. (nih.gov)
- Using a randomized, double-blind, placebo-controlled crossover trial, we evaluated the efficacy of a combined antioxidant preparation in the management of CP. (unboundmedicine.com)
- Treatment with Antox was associated with significant improvements in quality of life in terms of pain (+17 antioxidant vs. -7 placebo), physical (+9 vs. -3) and social functioning (+8 vs. -7), and general health perception (+10 vs. -3). (unboundmedicine.com)
- Selenium also plays an important antioxidant role in cardiovascular disease and studies have shown that serum and urinary levels of selenium are lower in patients who suffered acute myocardial infarcts or ischemic cardiomyopathy [ 13 ]. (biomedcentral.com)
- Scientists measured blood-plasma levels of selenium and found that on average, selenium levels were 24% below the minimum doctors believe is necessary to produce enough selenoproteins, the antioxidant enzymes that keep muscles healthy. (nutritionexpress.com)
- In preliminary reports, people with the lowest blood levels of selenium had between 3.8 and 5.8 times the risk of dying from cancer compared with those who had the highest selenium levels. (peacehealth.org)
- And while evidence indicates that selenium levels decline with advancing age, 19,20 it is perhaps not surprising that when researchers studied a population of very long-lived people, they found the highest selenium levels in individuals over 100 years old. (lifeextension.com)
- The most commonly used measures of selenium status are plasma and serum selenium concentrations [ 1 ]. (nih.gov)
- We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. (pubmedcentralcanada.ca)
- In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. (pubmedcentralcanada.ca)
- Vitamins B, C and E support immunity and selenium has been shown to reduce HIV replication in test tube studies. (aidsmap.com)
- Subjects received either daily multivitamins (B vitamins and vitamins C and E), selenium alone, or multivitamins with selenium or placebo for 24 months. (nutraceuticalsworld.com)
- The government-backed report by the Expert Group on Vitamins and Minerals (EVM) published last week "betrays an alarming level of bias" and "unhelpfully fails to discriminate between short-term and long-term use" according to Professor Arnold Beckett OBE BSc PhD DSc FRPharmS, one of the country's leading pharmacists and former President of the Royal Pharmaceutical Society. (positivehealth.com)
- Consistent with previous studies, we observed no protective effect of selenium on colorectal cancer among women. (aacrjournals.org)
- The current evidence from in vitro and animal studies strongly supports a protective effect of selenium on colorectal cancer, whereas the evidence from clinical trials and observational studies is inconclusive ( 1-15 ). (aacrjournals.org)
- Many observational studies ( 1-9 ), but not all ( 10-15 ), support a protective effect of selenium on risk of colorectal tumors. (aacrjournals.org)
- one reported no preventive effect of selenium against stomach, colorectal, oesophageal or lung cancer. (cam-cancer.org)
- Panel on Dietary Antioxidants and Related Compounds, Subcommittee on Upper Reference Levels of Nutrients, Subcommittee on Interpretation and Uses of DRIs, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. (springer.com)
- Selenium and vitamin E, both naturally occurring nutrients, are anti-oxidants. (uthscsa.edu)
- Intake recommendations for selenium and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the Institute of Medicine of the National Academies (formerly National Academy of Sciences) [ 6 ]. (nih.gov)
- The fact is that a large body of scientific evidence shows that several selenium-containing nutrients do reduce the risk of many types of cancers. (wholefoodsmagazine.com)
- Volunteers who were in the selenium group but did not achieve significantly higher serum levels of the metal were likely to skip their medication about 43% of the time, compared with about 14% of the time for responders. (medpagetoday.com)
- Depression was significantly associated with selenium levels, but not with folate or vitamin C levels. (nih.gov)
- Dietary selenium intake was not significantly correlated with the other indicators of selenium status, presumably because urinary selenium excretion reflected recent intake, and tissue selenium was homeostatically controlled. (springer.com)
- And in people with low baseline levels of selenium, the cancer-preventive effect rose significantly to 36% . (lifeextension.com)
- Large-scale epidemiologic studies have shown that populations with low selenium levels are at significantly increased risk for developing many different types of cancer. (lifeextension.com)
- 26,32-35 Specifically, selenium insufficiencies are now known to significantly increase risk of cancers of the bladder , lung , stomach , esophagus , and liver . (lifeextension.com)
- Margaret Rayman, professor of nutritional medicine at the University of Surrey, found that Selenium levels were significantly lower in Europeans than those in North Americans due to selenium-depleted European soil. (mineralresourcesint.com)
- 2 However, the selenium content of foods may vary significantly depending on plant and animal metabolism, growing conditions and animal nutrition, or even the geographic region from which the food originates. (cam-cancer.org)
- 100% of the Vemma group reported that they felt improvement in their health , significantly more than the control group. (vemma.com)
- The hospital stay was significantly shorter in Group I, at a mean (SD) of 34 (3.7) vs 45 (2.9) h (P (bvsalud.org)
- The duration of ureteric stenting was significantly lower in Group I as compared to Group II, at a mean (SD) of 12 (4.2) vs 25 (3.5) days (P (bvsalud.org)
- RESULTS: There was a significantly higher stone clearance rate of 83% in Group 1 vs 57% in Group 2 (P = 0.007). (bvsalud.org)
- And that antioxidants are no more effective than placebo in preventing heart attacks. (drmirkin.com)
- When I became Science Editor for WholeFoods in 1984, I wrote mainly about my own research, particularly with antioxidants and selenium. (wholefoodsmagazine.com)
- No between group differences were seen in the mean numbers of words said or signed: for antioxidants versus none the ratio of means was 0.85 (95% confidence interval 0.6 to 1.2), and for folinic acid versus none it was 1.24 (0.87 to 1.77). (bmj.com)
- The researchers conducted randomized, placebo-controlled and double blind trials. (thaindian.com)
- Given the challenges of using conventional pharmacotherapy to achieve and maintain virologic suppression," the researchers concluded, "our results support the use of selenium as a simple, inexpensive and safe adjunct therapy. (medpagetoday.com)
- The exact mechanism by which selenium exerts its effects on HIV-1 viral replication is not known," the researchers said. (medpagetoday.com)
- After adjusting their statistics so they wouldn't be thrown off by various factors, the researchers reported that those who took the combination were about half as likely to show signs over two years that their infection had progressed toward AIDS as those who took the placebo. (medicinenet.com)
- Researchers recently divided rabbits into two groups. (secondopinionnewsletter.com)
- Researchers in Sweden reported last year on over 400 healthy persons over age 70 who were given CoQ10 and another nutrient selenium or matching placebo pills. (mindbodygreen.com)
- Studies with mice have shown selenium supplementation increases immunity to flu , but similar evidence in humans is missing. (medicalnewstoday.com)
- There have been only a few controlled prevention trials to test the hypothesis that selenium can be protective against cancer in humans. (aacrjournals.org)
- Plasma selenium levels appear to predict mortality in humans as well. (lifeextension.com)
- Humans usually ingest selenium in crop-grown or animal products. (cam-cancer.org)
- 26 ,29 The lethal selenium dose for humans is unknown, but is estimated to be between 0.12g and 1g (120-1000mg). (cam-cancer.org)
- Outcome measures were Thyroid Stimulating Hormone (TSH) levels, thyroid peroxidase antibodies (TPOAb) and TgAb titer, selenium, and Myo-Inositol plasma concentration. (hindawi.com)
- Some blood will be used to measure selenium concentration. (isrctn.com)
- The high concentration of selenium in the Brazil nut may improve serum lipoprotein, due to its stimulation of the metabolically active form of thyroid hormones. (biomedcentral.com)
- As a result, the "non-responders" had selenium levels and HIV responses closer to the placebo group, Dr. Hurwitz and colleagues said. (medpagetoday.com)
- Selenium "non-responders" did not differ from the placebo group in HIV levels and CD4 counts. (medpagetoday.com)
- People with low levels of selenium have been shown to have lower levels of key components of the immune system, and a reduced ability to respond to viral infections. (medicalnewstoday.com)
- In parallel, the levels of molecules that T-cells use to kill infected cells were reduced by selenium supplementation. (medicalnewstoday.com)
- The group that took levothyroxine or levothyroxine + selenium had a reduction in TSH levels and increase in thyroid hormone levels, as desired. (wilsonssyndrome.com)
- And Graham Lyons discusses the levels of selenium in Australian soils and compares selenium levels in Australia with those elsewhere. (abc.net.au)
- One of the major ideas that selenium has been implicated in is that people with low selenium status tend to have impaired immune functioning, so there's strong evidence that the ingestion of adequate levels of selenium in the diet strongly improves one's immune response. (abc.net.au)
- wheat growing areas there is much, much higher levels of selenium in the soils, and so what we tend to find is that selenium concentrations in the grains of North American wheat is perhaps 30 to 50 times more concentrated in selenium than a wheat grain grown on a soil in England. (abc.net.au)
- Following 8 weeks of micronutrient supplementation, there was a significant increase in selenium levels and improved symptoms of depression occurred in a subgroup. (nih.gov)
- Higher blood selenium levels predicted a decreased HIV viral load, which in turn predicted increased CD4 count. (infectioncontroltoday.com)
- Selenium supplementation in the overweight group was effective at increasing plasma selenium levels to near recommended levels, which in turn decreased lipid hydroperoxides responses at rest and after high-intensity exercise. (drjeffreytucker.com)
- The lack of selenium supplementation effect on lipid hydroperoxide levels in the normal weight group may be explained by prior sufficient levels of selenium to support maximal expression of GSH-Px activity," they added. (drjeffreytucker.com)
- Their stored sera and those of 249 matched controls were measured for selenium levels. (aacrjournals.org)
- In a double-blinded, placebo-controlled trial, we demonstrate that carriers of colon adenomas present with low basal serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but both parameters can be normalized by interventional selenium supplementation. (unboundmedicine.com)
- Selenium levels decreased rapidly after the end of supplementation, and there were no significant differences in selenium status indicators between groups by week 96. (springer.com)
- People with low levels of selenium have a high risk of asthma. (peacehealth.org)
- Some medications can have a negative effect on selenium levels. (mineralresourcesint.com)
- For people who have healthy levels of selenium in their blood, there are clear risks of supplementing too much. (mineralresourcesint.com)
- The Vemma group was the only group to reduce their CRP levels from unhealthy to healthy levels. (vemma.com)
- In most of the studies analyzed, women with elevated levels tended to be older as a group compared to those women with normal antibody levels. (ivf1.com)
- Very well designed trials indicate that selenium supplementation may reduce the levels of some types of anti-thyroid antibodies. (ivf1.com)
- Approximately 150 pregnant with with elevated levels of one group of thyroid antibodies were split into two equal groups. (ivf1.com)
- Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. (pubmedcentralcanada.ca)
- In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 μg/L. (pubmedcentralcanada.ca)
- Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes. (pubmedcentralcanada.ca)
- Professor Beckett's group is particularly concerned by the EVM's stance on vitamin B6 and its recommendation that the maximum daily dosage should be reduced from the levels of 50-200 mg daily that have been safely employed for almost half-a-century to 10 mg daily. (positivehealth.com)
- Thyroid hormones can lower levels of atherogenic lipoproteins, and selenium is important in thyroid hormone homeostasis. (biomedcentral.com)
- The placebo group showed a reduction in FT 3 levels (−0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02). (biomedcentral.com)
- Seniors with higher selenium levels had stronger muscles than those with lower levels, and older adults who took creatine and CLA along with exercise had stronger, leaner muscles and less fat compared to placebo, in two studies. (nutritionexpress.com)
- Therefore, even mild selenium deficiency may contribute to the development and maintenance of autoimmune thyroid diseases. (hindawi.com)
- Research shows that taking 200 mcg of selenium daily along with thyroid hormone might decrease antibodies in the body that contribute to this condition. (webmd.com)
- Via its incorporation into more than two dozen selenoproteins throughout the body, 2,3 selenium provides potent defense against cancer-causing DNA damage , 4,5 facilitates removal of dangerous toxins from the body, 6 supports optimal thyroid function, 7 maintains immune system activity, 3,8,9 and much more. (lifeextension.com)
- The effects of endocrine disruptors and nutraceuticals and over-the-counter products (selenium, L-carnitine, thyroid hormones, iodine, and biotin) will also be discussed. (springer.com)
- Concentrations in blood and urine reflect recent selenium intake. (nih.gov)
- As a result, selenium concentrations in plant-based foods vary widely by geographic location [ 1 , 2 ]. (nih.gov)
- The difference in blood concentrations of omega-3 fatty acids between the lowest and highest risk groups was about 2.5 percentage points (3.2 percent vs. 5.7 percent), which is somewhat larger than the effect of eating salmon twice a week, Kristal said. (scienceblog.com)
- Plasma selenium biomarkers respond to selenium administration and might be useful for assessing compliance and safety in these trials. (nih.gov)
- After 48 weeks of supplementation, plasma selenium was increased 60% from 142 to 228 μg/l (1.8 to 2.9 μmol/l), and erythrocyte selenium was approximately doubled from 261 to 524 μg/l (3.3 to 6.6 μmol/l). (springer.com)
- However, when the scientists compared the 2 groups looking at the more life-threatening cancers they were astounded by what they found. (theherbprof.com)
- Based on its review, FDA does not agree that selenium may reduce the risk of these cancers. (wholefoodsmagazine.com)
- Vitamin E alone or with selenium did not reduce the risk of other cancers or diseases. (naturalmedicinejournal.com)
- Selenium appears to protect against a variety of cancers, including colon cancer. (peacehealth.org)
- Indeed, studies suggest that inadequate selenium increases risk of cardiovascular disease , 3,10 some cancers , 3,11-13 cognitive dysfunction , 14 and even death . (lifeextension.com)