Secretin. Medical search

A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)

Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. Most gastrointestinal hormones also act as neurotransmitters so these receptors are also present in the central and peripheral nervous systems.

The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.

A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.

A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.

The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.

A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).

The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.

HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.

Cell surface proteins that bind VASOACTIVE INTESTINAL PEPTIDE; (VIP); with high affinity and trigger intracellular changes which influence the behavior of cells.

Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.

A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.

A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.

A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Tumors or cancer of the APPENDIX.

A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.

Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).

Sequential operating programs and data which instruct the functioning of a digital computer.

Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. (1/608)

We have isolated, from canine pancreatic juice, two 14-kDa proteins with secretin-releasing activity that had N-terminal sequence homology with canine pancreatic phospholipase A2 (PLA2). In this study we have obtained evidence that secretin-releasing activity is an intrinsic property of pancreatic PLA2. Porcine pancreatic PLA2 from Sigma or Boehringer Mannheim was fractionated into several peaks by reverse phase high performance liquid chromatography. They were tested for stimulation of secretin release from murine neuroendocrine intestinal tumor cell line STC-1 and secretin cells enriched mucosal cell preparations isolated from rat upper small intestine. Each enzyme preparation was found to contain several components of secretin-releasing activity. Each bioactive fraction was purified to homogeneity by rechromatography and then subjected to mass spectral analysis and assays of PLA2 and secretin-releasing activities. It was found that the fraction with highest enzymatic activity also had the highest secretin-releasing activity and the same Mr as porcine pancreatic PLA2. Moreover, it also had the same N-terminal amino acid sequence (up to 30 residues determined) as that of porcine pancreatic PLA2, suggesting that it was identical to the enzyme. Purified porcine pancreatic PLA2 also stimulated secretin release concentration-dependently from both STC-1 cells and a mucosal cell preparation enriched in secretin-containing endocrine cells isolated from rat duodenum. Abolishment of the enzymatic activity by pretreatment with bromophenacyl bromide did not affect its secretin-releasing activity. The stimulatory effect of purified pancreatic PLA2 on secretin secretion from STC-1 cells was inhibited by an L-type Ca2+ channel blocker, by down-regulation of protein kinase C or by pretreatment of the cell with pertussis toxin. It is concluded that porcine pancreatic PLA2 possesses an intrinsic secretin-releasing activity that was independent of its enzymatic activity. This action is pertussis toxin-sensitive and is in part dependent on Ca2+ influx through the L-type channel and activation of protein kinase C. (+info)

COOH-terminally extended secretins are potent stimulants of pancreatic secretion. (2/608)

Posttranslational processing of preprosecretin generates several COOH-terminally extended forms of secretin and alpha-carboxyl amidated secretin. We used synthetic canine secretin analogs with COOH-terminal -amide, -Gly, or -Gly-Lys-Arg to examine the effects of COOH-terminal extensions of secretin on bioactivity and detection in RIA. Synthetic products were purified by reverse-phase and ion-exchange HPLC and characterized by reverse-phase isocratic HPLC and amino acid, sequence, and mass spectral analyses. Secretin and secretin-Gly were noted to coelute during reverse-phase HPLC. In RIA using eight different antisera raised against amidated secretin, COOH-terminally extended secretins had little or no cross-reactivity. Bioactivity was assessed by measuring pancreatic responses in anesthetized rats. Amidated canine and porcine secretins were equipotent. Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P > 0.05) and 176 +/- 13% (P < 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer. These data demonstrate that 1) amidated secretin and secretin-Gly are not separable under some chromatographic conditions, 2) current RIA may not detect bioactive COOH-terminally extended forms of secretin in tissue extracts or blood, and 3) the secretin receptor mediating stimulation of pancreatic secretion recognizes both amidated and COOH-terminally extended secretins. (+info)

Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. (3/608)

The mechanisms responsible for intrapancreatic digestive enzyme activation as well as the relationship between that activation and cell injury during pancreatitis are not understood. We have employed an in vitro system in which freshly prepared pancreatic acini are exposed to a supramaximally stimulating concentration of the CCK analog caerulein to explore these issues. We find that in vitro trypsinogen activation depends on the continued presence of Ca2+ in the suspending medium and that it is half-maximal in the presence of 0.3 mM Ca2+. Caerulein-induced trypsinogen activation can be halted by removal of Ca2+ from the suspending medium or by chelation of intracellular Ca2+. Increasing intracellular Ca2+ with either ionomycin or thapsigargin does not induce trypsinogen activation. We have monitored cell injury by measuring the leakage of lactate dehydrogenase (LDH) from acini and by quantitating intercalation of propidium iodide (PI) into DNA. Leakage of LDH and intercalation of PI in response to supramaximal stimulation with caerulein can be detected only after caerulein-induced trypsinogen activation has already occurred, and these indications of cell injury can be prevented by addition of a cell-permeant protease inhibitor. Our findings indicate that caerulein-induced intra-acinar cell activation of trypsinogen depends on a rise in intracellular Ca2+, which reflects entry of Ca2+ from the suspending medium. Intra-acinar cell activation of trypsinogen is an early as well as a critical event in pancreatitis. The subsequent cell injury in this model is mediated by activated proteases. (+info)

Vagus nerve modulates secretin binding sites in the rat forestomach. (4/608)

Secretin is well known for its inhibitory action on gastric motility. It has been reported that secretin in a physiological dose inhibits gastric motility through mediation by the vagal afferent pathway. Secretin also elicited relaxation of carbachol-stimulated rat forestomach muscle strips by binding to its receptors, suggesting a direct action on this peripheral tissue. We hypothesized that vagal input may affect the action of secretin by modulating the level of secretin receptor in the forestomach. Several treatments, including vagal ligation, vagotomy, perivagal application of capsaicin or colchicine, intravenous infusion of tetrodotoxin, and intraperitoneal injection of atropine, were performed to investigate their effects on secretin receptor binding to forestomach membranes. Specific binding of 125I-labeled secretin to forestomach membranes was significantly decreased (45%) by vagal ligation, vagotomy (50%), or perivagal colchicine treatment (40%). On the contrary, specific binding of 125I-secretin was not affected by perivagal capsaicin treatment, intravenous infusion of tetrodotoxin, or intraperitoneal injection of atropine. By Scatchard analysis of the binding data, the capacity of the high-affinity binding sites in forestomach membranes was found to decrease significantly after vagal ligation compared with membranes from the sham-operated group. However, the affinity at the high-affinity binding sites, the binding parameters of the low-affinity binding sites, and binding specificity were not changed. Vagal ligation but not perivagal capsaicin treatment reduced the inhibitory effect of secretin on bethanechol-stimulated contraction of isolated forestomach muscle strips, causing a right shift in the dose-response curve. These results suggest that vagal input through axonal transport plays a significant role on secretin action by modulating the capacity of secretin binding sites (but not affinity or specificity), at least in rat forestomach. (+info)

Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. (5/608)

Bile duct damage and/or loss is limited to a range of duct sizes in cholangiopathies. We tested the hypothesis that CCl4 damages only large ducts. CCl4 or mineral oil was given to bile duct-ligated (BDL) rats, and 1, 2, and 7 days later small and large cholangiocytes were purified and evaluated for apoptosis, proliferation, and secretion. In situ, we measured apoptosis by morphometric and TUNEL analysis and the number of small and large ducts by morphometry. Two days after CCl4 administration, we found an increased number of small ducts and reduced number of large ducts. In vitro apoptosis was observed only in large cholangiocytes, and this was accompanied by loss of proliferation and secretion in large cholangiocytes and loss of choleretic effect of secretin. Small cholangiocytes de novo express the secretin receptor gene and secretin-induced cAMP response. Consistent with damage of large ducts, we detected cytochrome P-4502E1 (which CCl4 converts to its radicals) only in large cholangiocytes. CCl4 induces selective apoptosis of large ducts associated with loss of large cholangiocyte proliferation and secretion. (+info)

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. (6/608)

The seven transmembrane helices of serpentine receptors comprise a conserved switch that relays signals from extracellular stimuli to heterotrimeric G proteins on the cytoplasmic face of the membrane. By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding site whose occupancy by Zn(II) prevented the receptor from activating a retinal G protein, Gt (Sheikh, S. P., Zvyaga, T. A. , Lichtarge, O., Sakmar, T. P., and Bourne, H. R. (1996) Nature 383, 347-350). Now we report engineering of metal-binding sites bridging the cytoplasmic ends of these two helices in two other serpentine receptors, the beta2-adrenoreceptor and the parathyroid hormone receptor; occupancy of the metal-binding site by Zn(II) markedly impairs the ability of each receptor to mediate ligand-dependent activation of Gs, the stimulatory regulator of adenylyl cyclase. We infer that these two receptors share with rhodopsin a common three-dimensional architecture and an activation switch that requires movement, relative to one another, of helices III and VI; these inferences are surprising in the case of the parathyroid hormone receptor, a receptor that contains seven stretches of hydrophobic sequence but whose amino acid sequence otherwise shows no apparent similarity to those of receptors in the rhodopsin family. These findings highlight the evolutionary conservation of the switch mechanism of serpentine receptors and help to constrain models of how the switch works. (+info)

Duodenal acid-induced gastric relaxation is mediated by multiple pathways. (7/608)

In this study, we used an in vivo anesthetized rat model to investigate the mechanisms responsible for duodenal acid-induced inhibition of gastric motility. Intraduodenal infusion of HCl produced a rate-dependent decrease in intragastric pressure. Infusion of HCl at 2 ml/h produced a physiological plasma secretin level and elicited a decrease in intragastric pressure of 3.0 +/- 0. 2 cmH20. Infusion of rabbit secretin antiserum reduced the acid-induced inhibition of gastric motility by 85 +/- 5%, suggesting mediation mainly by endogenous secretin. Administration of the cholecystokinin (CCK)-A antagonist MK-329 caused only a modest 10 +/- 3% reduction in gastric relaxation, whereas the serotonin antagonist ICS-205930 had no effect. In contrast, immunoneutralization with the secretin antibody caused only a 15% reduction in the relaxation evoked by a higher rate of HCl infusion (3 ml/h), whereas MK-329 and ICS-205930 caused a 20 +/- 4% reduction and no reduction, respectively. Bilateral truncal vagotomy or perivagal application of capsaicin completely abolished gastric relaxation in response to low rates (1-2 ml/h) of 0.1 N HCl infusion but only partially affected gastric relaxation in response to a higher infusion rate (3 ml/h). These observations indicate that multiple pathways mediate the duodenal acid-induced inhibition of gastric motility. At low rates of HCl infusion, gastric relaxation is mediated primarily by endogenous secretin, which acts through vagal afferent pathways. At higher rates of HCl infusion, gastric relaxation is mediated by endogenous secretin, CCK, and possibly by the direct action of HCl on vagal afferent pathways or yet unidentified neuropathways. (+info)

Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor. (8/608)

Photoaffinity labeling is a powerful tool for the characterization of the molecular basis of ligand binding. We recently used this technique to demonstrate the proximity between a residue within the carboxyl-terminal half of a secretin-like ligand and the amino-terminal domain of the secretin receptor (Dong, M., Wang, Y., Pinon, D. I., Hadac, E. M., and Miller, L. J. (1999) J. Biol. Chem. 274, 903-909). In this work, we have developed another novel radioiodinatable secretin analogue ([Bpa6,Tyr10]rat secretin-27) that incorporates a photolabile p-benzoyl-L-phenylalanine (Bpa) residue into position 6 of the amino-terminal half of the ligand and used this to identify a specific receptor residue proximate to it. This probe specifically bound to the secretin receptor with high affinity (IC50 = 13.2 +/- 2.5 nM) and was a potent stimulant of cAMP accumulation in secretin receptor-bearing Chinese hamster ovary-SecR cells (EC50 = 720 +/- 230 pM). It covalently labeled the secretin receptor in a saturable and specific manner. Cyanogen bromide cleavage of this molecule yielded a single labeled fragment that migrated on an SDS-polyacrylamide gel at Mr = 19,000 that shifted to 10 after deglycosylation, most consistent with either of two glycosylated fragments within the amino-terminal tail. By immunoprecipitation with antibody directed to epitope tags incorporated into each of the two candidate fragments, the most distal fragment at the amino terminus was identified as the domain of labeling. The labeled domain was further refined to the first 16 residues by endoproteinase Lys-C cleavage and by cyanogen bromide cleavage of another receptor construct in which Val16 was mutated to Met. Radiochemical sequencing of photoaffinity-labeled secretin receptor fragments established that Val4 was the specific site of covalent attachment. This provides the first residue-residue contact between a secretin ligand and its receptor and will contribute substantially to the molecular understanding of this interaction. (+info)

... targets the pancreas; pancreatic centroacinar cells have secretin receptors in their plasma membrane. As secretin ... Secretin also has an amidated carboxyl-terminal amino acid which is valine. The sequence of amino acids in secretin is H-His- ... In humans, the secretin peptide is encoded by the SCT gene. Secretin helps regulate the pH of the duodenum by (1) inhibiting ... Secretin is used in a diagnostic tests for pancreatic function; secretin is injected and the pancreatic output can then be ...

https://en.wikipedia.org/wiki/Secretin

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., ... IUPHAR GPCR Database - Secretin receptor secretin+receptor at the US National Library of Medicine Medical Subject Headings ( ... Secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide. GRCh38: Ensembl release 89: ... Ho PK, Fong RS, Kai HS, Lau EH, Ngan ES, Cotton CU, Chow BK (July 1999). "The human secretin receptor gene: genomic ...

https://en.wikipedia.org/wiki/Secretin_receptor

Glucagon/gastric inhibitory polypeptide/secretin/vasoactive intestinal peptide hormones are a family of evolutionarily related ... Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, ... peptide hormones that regulate activity of G-protein-coupled receptors from the secretin receptor family. A number of ...

https://en.wikipedia.org/wiki/Secretin_family

"Jacques Secretin". Royal Belgian Football Association. Retrieved 3 September 2021. Jacques Secretin at FootballDatabase.eu v t ... "Jacques Secretin". worldfootball.net. Retrieved 3 September 2021. "Jacques Secretin". National Football Teams. Retrieved 3 ... Jacques Secretin (28 December 1907 - 29 December 1978) was a Belgian footballer. He played in three matches for the Belgium ...

https://en.wikipedia.org/wiki/Jacques_Secretin_(footballer)

The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin ... Secretin family receptor proteins, also known as Family B or family 2 of G-protein coupled receptors are regulated by peptide ... The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in ... However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own ...

https://en.wikipedia.org/wiki/Secretin_receptor_family

The secretin-cholecystokinin test (aka Secretin-CCK test, Secretin-Pancreozymin test) is a combination of the secretin test and ... The concentration and output of bicarbonate with the secretin-CCK test is similar to what has been observed with the standard ... secretin test . The secretin-induced rapid flow of water results in lower and often unreliable enzyme concentrations. CCK also ... reviewed the relative diagnostic value of enzyme and bicarbonate concentrations compared with enzyme output in 363 secretin-CCK ...

https://en.wikipedia.org/wiki/Secretin-cholecystokinin_test

"Jacques Secretin". Royal Belgian Football Association. Retrieved 10 November 2017. "Corneel Seys". Royal Belgian Football ...

https://en.wikipedia.org/wiki/List_of_Belgium_international_footballers_(1–4_caps)

p. B.1. Kalk, Samara (May 24, 1999). "Scrambling for secretin; questions remain on new treatment for autism...but parents want ... p. 1. Maugh II, Thomas H. (December 9, 1999). "In clinical trial, hormone shows no effect on autism; health: secretin, which ... Rimland advocated the use of secretin, a "naturally occurring intestinal hormone, saying it was "possibly the most important ... and false claims of a link between secretin and autism. He also supported the ethically controversial practice of using ...

https://en.wikipedia.org/wiki/Bernard_Rimland

"SECRETIN Jacques (FRA)". ITTF.com. Archived from the original on 16 October 2012. Retrieved 1 March 2018. Montague, Trevor ( ...

https://en.wikipedia.org/wiki/Claude_Bergeret

Beck had with regard to hers, namely that while, prior to Aaron receiving secretin, "You couldn't get Aaron to look at you at ... Rimland, Bernard (1999). "Secretin: Positive, Negative Media Reports in the Top of the First Inning" (PDF). Autism Research ... In addition to his research on secretin and autism, Horvath is well known for his research into, and advocacy for awareness of ... After she did so, Horvath injected Parker with an intravenous dose of secretin as part of his diagnostic tests, and according ...

https://en.wikipedia.org/wiki/Karoly_Horvath

In 1961, Jorpes and the docent Viktor Mutt isolated the hormone secretin. Jorpes was known as a strong personality. There was ... ISBN 978-981-31446-3-7. Jorpes, Johan Erik; Mutt, Viktor (1973). Secretin, Cholecystokinin, Pancreozymin and Gastrin. Berlin: ...

https://en.wikipedia.org/wiki/Erik_Jorpes

Secretin - a hormone that controls the secretions into the duodenum, and also separately, water homeostasis throughout the body ... Wikipedia:Notice board for autism-related topics Barrett, Stephen (11 May 2015). "Secretin Found Ineffective for Treating ...

https://en.wikipedia.org/wiki/Outline_of_autism

... especially secretin. Its function is to complete the process begun by pancreatic juice; the enzyme trypsin exists in pancreatic ...

https://en.wikipedia.org/wiki/Intestinal_gland

Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ...

https://en.wikipedia.org/wiki/Enterogastrone

The stomach itself is protected from the strong acid by the secretion of a thick mucus layer, and by secretin induced buffering ... ISBN 978-0-7216-8677-6. Bowen R (18 March 2003). "Control and Physiologic Effects of Secretin". Colorado State University. ...

https://en.wikipedia.org/wiki/Hydrochloric_acid

Allison, Wes (14 May 2000). "Secretin: miracle drug or a quack remedy?". St. Petersburg Times. Retrieved 19 September 2013. ...

https://en.wikipedia.org/wiki/Jeff_Bradstreet

"Secretin-Association for Science in Autism Treatment". Archived from the original on 2013-10-29. Retrieved 2013-10-20. Herbs ... They take a similar viewpoint with regard to the use of secretin. Treatments they consider to be unproven, rather than ...

https://en.wikipedia.org/wiki/Association_for_Science_in_Autism_Treatment

These include secretin, acetylcholine, ATP, and bombesin. Cholangiocytes act through bile-acid independent bile flow, which is ...

https://en.wikipedia.org/wiki/Cholangiocyte

Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the ...

https://en.wikipedia.org/wiki/Endocrine_gland

This hormone was named gastric secretin or gastrin. But it was not until 1979 and later in 1987 and 1988 that progastrin was ...

https://en.wikipedia.org/wiki/Progastrin

Note that the mechanism underlying this test is in contrast to the normal physiologic mechanism whereby secretin inhibits ... The diagnosis is made through several laboratory tests and imaging studies: Secretin stimulation test, which measures evoked ... Bradley, E L; Galambos, J T (1976). "Diagnosis of gastrinoma by the secretin suppression test". Surgery, Gynecology & ... Gastrinoma cells release gastrin in response to secretin stimulation, thereby providing a sensitive means of differentiation. ...

https://en.wikipedia.org/wiki/Zollinger–Ellison_syndrome

Secretin family Drucker DJ, Nauck MA (November 2006). "The incretin system: glucagon-like peptide-1 receptor agonists and ...

https://en.wikipedia.org/wiki/Incretin

Gastrin and secretin may also act as secretagogues. It works in conjunction with the parietal cell, which releases gastric acid ...

https://en.wikipedia.org/wiki/Gastric_chief_cell

They called this substance secretin and Starling proposed that the body produces many secretin-like molecules, and in 1905 ... 2. The discovery of the hormone secretin-with his brother-in-law William Bayliss-and the introduction of the word hormone. 3. ... with secretin being prominent. The assessor, J. E. Johansson, decided that Starling should receive the prize, but not yet[ ...

https://en.wikipedia.org/wiki/Ernest_Starling

A member of the secretin/glucagon hormone superfamily. VIP was initially discovered owing to its potent vasodilatory effects ( ...

https://en.wikipedia.org/wiki/Aviptadil

... belongs to the secretin family of hormones. Glucagon is a 29-amino acid polypeptide. Its primary structure in humans ...

https://en.wikipedia.org/wiki/Glucagon

The secretion of bicarbonate from the pancreas is stimulated by secretin. This polypeptide hormone gets activated and secreted ... and secretin all inhibit production. The production of gastric acid in the stomach is tightly regulated by positive regulators ...

https://en.wikipedia.org/wiki/Gastric_acid

It has been suggested that this is due to abnormalities in the secretion of secretin in the brain and that "Secretin as a ... "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences. 106 ...

https://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormone_secretion

They correspond to classical classes C (class C, glutamate), A (rhodopsin-like), B2 (Secretin receptor family, long N-terminal ... GRAFS stands for Glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin. ... F (Frizzled/Smoothened), and B1+3 (other secretin). Taste2 has more recently considered to be closer to Rhodopsin-like ...

https://en.wikipedia.org/wiki/GRAFS

Secretin was discovered in 1902 by E. H. Starling. It was later linked to chemical regulation and was the first substance to be ... 2000). "Secretin, its discovery, and the introduction of the hormone concept.". Scand J Clin Lab Invest. 2000 Oct;60(6):463-71 ... Gastrin Cholecystokinin (CCK) The Secretin family are peptides that act as local hormones which regulate activity of G-protein ... Secretin Glucagon Glicentin (GLI) Vasoactive intestinal peptide (VIP) Gastric inhibitory polypeptide (GIP) Motilin Neurotensin ...

https://en.wikipedia.org/wiki/Local_hormone

The small intestine produces secretin when partially digested food from the stomach moves into ... The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. ... The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. The small intestine ... Secretin causes the pancreas to release a fluid that contains digestive enzymes. These enzymes break down food and help the ...

https://medlineplus.gov/ency/article/003892.htm

Posts about secretin written by What Doctors Dont Tell You ...

https://healthy.net/tag/secretin/

Investigative reporting about corporate malfeasance and government wrongdoing, analysis of national and world affairs, and cultural criticism that matters.

https://inthesetimes.com/article/bad-brains-mother-jones-tells-slaughterhouse-horror-story

The plasma levels of secretin have been measured in mothers after labour, and in their babies at birth and on day 4 of life. ... The level had again increased by day 4, and at this time the secretin level was inversely proportional to the blood glucose ...

https://adc.bmj.com/content/50/2/120

... - Product info ... production species: rabbit Secretin (SCT) Enzyme-linked ...

https://gentaur.com/enlibio/rabbit-secretin-sct-elisa-kit-01017007636

Can autism be effectively treated with secretin? The hormone, produced by the small intestine to incite secretion of pancreatic ... Secretin Trials: A drug that might help, or hurt, autistic children is widely prescribed but is just now being tested. Image ... Thousands have now received secretin, many of whom are getting repeated doses, although it has been approved by the Food and ... Can autism be effectively treated with secretin? The hormone, produced by the small intestine to incite secretion of pancreatic ...

https://www.the-scientist.com/news/secretin-trials-a-drug-that-might-help-or-hurt-autistic-children-is-widely-prescribed-but-is-just-now-being-tested-56430

Secretin-induced Duodenal Aspirate of Pancreatic Juice (SIDA): Utility of Commercial Genetic Analysis. ... Secretin-induced Duodenal Aspirate of Pancreatic Juice (SIDA): Utility of Commercial Genetic Analysis. Journal Article (Journal ... BACKGROUND: Secretin-induced duodenal aspiration (SIDA) of pancreatic duct fluid has been proposed for pancreatic neoplasm ...

https://scholars.duke.edu/display/pub1533077

Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of `choleraic diarrhoea ... Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of `choleraic diarrhoea ... Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of `choleraic diarrhoea ...

https://gut.bmj.com/content/11/3/206.citation-tools

... and the bile flow induced by secretin (54%, P , 0.05). Our results in vivo indicate that secretin induces the microtubule- ... and the bile flow induced by secretin (54%, P , 0.05). Our results in vivo indicate that secretin induces the microtubule- ... and the bile flow induced by secretin (54%, P , 0.05). Our results in vivo indicate that secretin induces the microtubule- ... and the bile flow induced by secretin (54%, P , 0.05). Our results in vivo indicate that secretin induces the microtubule- ...

https://jhu.pure.elsevier.com/en/publications/secretin-induces-the-apical-insertion-of-aquaporin-1-water-channe-3

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Home / Peptides / Secretin Acetate. Secretin Acetate. CAS Number: 17034-35-4. Product InfoStructurePhysical PropertiesProduct ...

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Secret history contains an important lesson that extends beyond autism.. "Many families, if not a majority of families" with a child suffering from autistic spectrum disorder (ASD)"persecution Dietary and nutritional approaches as components of treatment. Estimates of the use of alternative therapies range from 28 to 95 percent, with special diets or dietary supplements the most frequently cited approach. Why so common? My video Alternative treatments for autism explore the issue.. Maybe. performance about the suspicion or distrust of standard medical practices, the desire not to have their children drugged or the desire to seek healing treatment due to frustration with deficiencies in traditional medical interventions, therapies based on dietary interventions appeal to parents of children with autism as safer, natural and holistic approaches to treating their children, but it could also be simply because drugs do not work.. "The pharmaceutical interventions in the ASD are mainly Target ...

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Secretin therapy. Several anecdotal reports suggested that secretin, a gastrointestinal hormone that may function as a ... This led to several scientific studies of secretin for children with ASD. [190, 191, 192] However, 2 reviews of these trials ... Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2012 Apr 18. 4:CD003495. [QxMD MEDLINE ... Krishnaswami S, McPheeters ML, Veenstra-Vanderweele J. A systematic review of secretin for children with autism spectrum ...

https://emedicine.medscape.com/article/912781-treatment

Chemical Compound SECRETIN , Compound overview, Drug targets, Compound forms, Similar compounds , canSAR.ai ...

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Dive into the research topics of Agonist-stimulated phosphorylation of the carboxyl-terminal tail of the secretin receptor. ... Agonist-stimulated phosphorylation of the carboxyl-terminal tail of the secretin receptor. ...

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Porcine secretin acetate salt,RG-1068,SECRETIN SYNTHETIC PORCINE,Secreflo,Secretin (swine), acetate (salt),Secretin porcine ... pentaacetate,Secretin synthetic porcine,canSAR2689121 , Compound overview, Drug targets, Compound forms, Similar compounds , ...

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Enzyme development and post-natal feeding / editors, H. R. Müller, M. C. Secretin. by Müller, H. R , Secretin, M. C , Nestlé ... by Müller, H. R , Secretin, M. C , Nestlé Company.. Series: Nestlé symposium ; [1]Material type: Text; Format: print ... Données physiologiques et anomalies du métabolisme chez le nourrisson / editeur, H. R. Müller ; rédaction, M. C. Secretin. ... Results of search for ccl=pl:[s.l. : and au:Secretin, M. C. ...

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What is secretin?. A hormone that is made by glands in the small intestine whose primary function is the stimulation of ...

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Radioimmunoassay of secretin in human serum. Bonora G, Vezzadini P, Toni R, Labò G. Bonora G, et al. Among authors: labo g. ... Secretin]. Labò G, Vannini P. Labò G, et al. Actual Hepatogastroenterol (Paris). 1964:65-83. Actual Hepatogastroenterol (Paris ...

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Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2012 Apr 18. 4:CD003495. [QxMD MEDLINE ... Krishnaswami S, McPheeters ML, Veenstra-Vanderweele J. A systematic review of secretin for children with autism spectrum ...

https://www.medscape.com/answers/912781-193663/which-patient-groups-have-the-highest-prevalence-of-autism-spectrum-disorder-asd

A high-efficiency screening device for secretin monoclonal antibodies_Nanjing Synthgene Medical Technology Co., Ltd.

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Secretin induces variable inhibition of motility in different parts of the Australian possum sphincter of Oddi. / Al-Jiffry, B ... Secretin induces variable inhibition of motility in different parts of the Australian possum sphincter of Oddi. In: ... Al-Jiffry B, Jobling J, Schloithe A, Toouli J, Saccone G. Secretin induces variable inhibition of motility in different parts ... title = "Secretin induces variable inhibition of motility in different parts of the Australian possum sphincter of Oddi", ...

https://researchnow.flinders.edu.au/en/publications/secretin-induces-variable-inhibition-of-motility-in-different-par

EFFECT OF GASTROINTESTINAL HORMONES, SECRETIN AND CHOLECYSTOKININ-PANCREOZYMIN, ON INSULIN AND GLUCAGON RELEASE IN HEALTHY AND ...

https://oparu.uni-ulm.de/xmlui/handle/123456789/10235?locale-attribute=de

7tm_2; 7 transmembrane receptor (Secretin family). pfam01825. Location:2684 → 2727. GPS; GPCR proteolysis site, GPS, motif. ... 7tm_2; 7 transmembrane receptor (Secretin family). pfam01825. Location:2684 → 2727. GPS; GPCR proteolysis site, GPS, motif. ... 7tm_2; 7 transmembrane receptor (Secretin family). pfam01825. Location:2621 → 2664. GPS; GPCR proteolysis site, GPS, motif. ...

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PP: Secretins. Glucagon. Glucagon receptor. - PP: Secretins. Vasoactive intestinal peptide. VIP. Vasoactive intestinal peptide ... PP: Secretins. Secretin. Secretin receptor. - PP: Secretins. Motilin. Motilin receptor. - ...

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The Effect of Chronic Intermittent Cold Exposure on Gastrin-, Somatostatin-, Secretin- and Serotonin-Containing Cells in the ...

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The Hormone Secretin Induces Satiation by Activating Brown Fat. Why You Lose Weight on a Ketogenic Diet. ...

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Secretin and the exposition of hormonal control. Journal of Physiology 2004, 560(2), 339-339. ...

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Recently, the first crystal structure of a RAMP ECD in complex with a secretin family GPCR was solved, revealing the elegant mechanism governing receptor selectivity of small molecule antagonists of the calcitonin gene-related peptide (CGRP) receptor. (nih.gov)

To assess whether intravenous secretin improves the core features of ASD, other aspects of behaviour or function such as self-injurious behaviour, and the quality of life of affected individuals and their carers. (nih.gov)
Randomised controlled trials of intravenous secretin compared to a placebo treatment in children or adults diagnosed with ASD, where at least one standardised outcome measure was reported. (nih.gov)
The Cochrane Review summary, Intravenous Secretin for Autism Spectrum Disorder, reports on 14 studies on autism and secretin therapy. (tadakaluri.com)
Evidence suggests that single or multiple dose intravenous secretin, a gastrointestinal hormone, is not effective as a treatment for ASD. (nih.gov)
A 2012 Cochrane review of 16 randomized controlled trials of intravenous secretin compared to placebo in a total of more than 900 children found no improvements for core features of ASD. (nih.gov)

Secretion of low doses along with ceruletide increases the protective effect of secretin. (extremepeptides.com)
Potentiating effect of secretin on cholecystokinin-stimulated exocrine pancreatic secretion in rats]. (semanticscholar.org)
In vivo studies suggest that KSG-504 has significant inhibitory effects both on the pancreatic exocrine and endocrine secretion stimulating by CCK, but has no effect on the exocrine secretion stimulated by secretin. (semanticscholar.org)
The major physiological actions of secretin are stimulation of pancreatic fluid and bicarbonate secretion. (bridgesfamilywellness.com)
Secretin release is inhibited by H 2 antagonists, which reduce gastric acid secretion. (bridgesfamilywellness.com)
Secretin also inhibits the secretion of gastrin, which triggers the initial release of hydrochloric acid into the stomach, and delays gastric emptying. (bridgesfamilywellness.com)
secretion (including his secretin). (who.int)
How doe the EN/ ANS affect motility & secretion? (flashcardmachine.com)

Secretin family G protein-coupled receptors (GPCRs) are important therapeutic targets for migraine, diabetes, bone disorders, inflammatory disorders and cardiovascular disease. (nih.gov)
Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand. (ualg.pt)
The 15-member secretin family of G-protein coupled receptors (GPCRs) have in common peptide liganding and coupling through Gs, to cause elevation of intracellular cyclic AMP (cAMP). (nih.gov)

We assessed evidence of the effects of secretin on behavior in individuals with autistic disorder. (medscape.com)
Rats that were placed unconscious were given intravenous cerultide in large applications to develop acude pancreatitis to determine the effects of secretin on the body. (extremepeptides.com)
trospium chloride decreases effects of secretin by pharmacodynamic antagonism. (medscape.com)

Laboratory studies to confirm the diagnosis of Zollinger-Ellison syndrome (ZES) measurements of the fasting serum and gastrin levels, secretin and calcium stimulation tests, and measurements of the basal acid output. (medscape.com)
If the gastrin level is in the range of 100-1000 pg/mL, and the pH level is less than 2, a secretin stimulation test must be performed. (medscape.com)
After obtaining blood to measure the basal gastrin level, intravenously (IV) administer 2 IU/kg of secretin. (medscape.com)
Prior to injection of ChiRhoStim® (Human Secretin for injection), two blood samples are drawn for determination of fasting serum gastrin levels (baseline values). (human-secretin.com)
Gastrinoma is strongly indicated in patients who show an increase in serum gastrin concentration of at least 110 pg/mL over basal level on any of the post secretin injection samples. (human-secretin.com)
Of the available gastrin stimulation/provocation tests, the secretin stimulation test should be performed as the first line test with the calcium stimulation test only being used if there is still diagnostic uncertainty. (medscape.com)
The five major hormones are: gastrin ( stomach ), secretin ( small intestine ), cholecytokinin (small intestine), gastric inhibitory peptide (small intestine), and motilin (small intestine). (bridgesfamilywellness.com)
How does secretin effect gastrin? (bridgesfamilywellness.com)
Further, he did an extensive research in studying the structure and purification of gastrointestinal hormones such as Gastrin, Secretin and Cholecystokinin. (cmeindia.in)

Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. (medscape.com)

Czako L. Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatography. (stanford.edu)
On secretin-stimulated magnetic resonance cholangiopancreatography (MRCP), the main pancreatic duct was seen traveling into and out of the fluid collection but not within it ([ Fig. 3 ]), suggesting its complete disruption (disconnected pancreatic duct syndrome). (thieme-connect.de)
Fig. 3 Secretin-stimulated magnetic resonance cholangiopancreatography showing disconnected pancreatic duct syndrome. (thieme-connect.de)

The endocrine polypeptide (APUD) cells responsible for the production and storage of secretin have been demonstrated, in canine duodenum, by the application of an indirect immunofluorescence technique, using anti-pure porcine secretin, to carbodiimide-fixed cryostat sections. (bmj.com)
Secretin acetate is a hormone that is responsible for controlling the environment of a duodenum by regulating pancreatic and stomach secretions while regulating the water homeostasis throughout an animal's body. (extremepeptides.com)
As a result, if the pH in the duodenum increases above 4.5, secretin cannot be released. (bridgesfamilywellness.com)
inject Secretin to stimulate pancreatic digestive fluid, which is collected in duodenum near ampulla via endoscope suction port. (clinicaltrials.gov)
Hunger signals are also triggered by the duodenum by releasing the hormones secretin and cholecystokinin via the duodenal epithelium. (reference.com)

Secretin-enhanced MRCP is a non-invasive method of evaluating both pancreatic morphology and function that utilizes intravenously injected secretin to characterize the pancreatic ductal system and to stimulate pancreatic exocrine function. (stanford.edu)
Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine function. (stanford.edu)
The tube is used in the secretin test for pancreatic exocrine function. (thefreedictionary.com)

The solution conformation of the 27 residue polypeptide hormone secretin has been investigated by 1H-NMR spectroscopy under conditions where it adopts a fully ordered structure as judged by circular dichroism spectroscopy, namely in an aqueous solution of 40% (v/v) trifluoroethanol. (nih.gov)
Numerous studies have shown that use of the hormone secretin, which stimulates the pancreas, may help many autistic people. (simonandschuster.com)

Two formulations, porcine and synthetic human secretin, were evaluated in humans. (medscape.com)

The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. (medlineplus.gov)
Secretin causes the pancreas to release a fluid that contains digestive enzymes. (medlineplus.gov)
The secretin stimulation test is done to check the digestive function of the pancreas. (medlineplus.gov)
Secretin is one of the hormones that controls digestion and its primary function relates to the pancreas. (tadakaluri.com)
Since secretin is an agent that can affect the pancreas, some believe that secretin injections may create enzymes that improve the digestive functioning. (tadakaluri.com)
Secretin functions as a type of fireman: it is released in response to acid in the small intestine, and stimulates the pancreas and bile ducts to release a flood of bicarbonate base, which neutralizes the acid. (bridgesfamilywellness.com)
Secretin is a hormone commonly used to treat peptic ulcers and test the function of the pancreas. (cnn.com)

Structural determination of several secretin family GPCR ECDs in complex with peptide ligands has been achieved recently, providing insight into the molecular determinants of hormone binding. (nih.gov)
The ligand for SCTR in mammals is secretin (SCT), an important gastrointestinal peptide, which in teleosts has not yet been isolated, or the gene identified. (ualg.pt)

You are given secretin through a vein (intravenously). (medlineplus.gov)
Subsequently, a test dose of ChiRhoStim® (Human Secretin for Injection) 0.2 mcg (0.1 mL) is injected intravenously to test for possible allergies. (human-secretin.com)

Secretin stimulates the flow of bile from the liver to the gallbladder. (bridgesfamilywellness.com)

Here we review the structural basis of ligand binding to secretin family GPCRs, concentrating on recent progress made on the structural basis of RAMP-modified GPCR pharmacology and its implications for rational drug design. (nih.gov)
Evolution of secretin family GPCR members in the metazoa. (ualg.pt)

Secretin, a gastrointestinal hormone, is suggested to improve autistic symptoms, particularly social function and communication. (medscape.com)
A number of controlled clinical trials did not show improvement in autistic symptoms with secretin compared with placebo, possibly indicating no role for the drug in autistic disorder. (medscape.com)
The Association for Science in Autism Treatment (ASAT) lists various treatments for autistic disorders, including secretin. (tadakaluri.com)
Secretin therapy is not an evidence-based treatment for autistic disorders and is therefore among the ASAT's list of questionable and unproven approaches. (tadakaluri.com)

Secretin was one of the first hormones to be identified in 1902 by Ernest Starling and William Bayliss who were looking to understand more about how the nervous system works to control digestion. (extremepeptides.com)
Much of the research surrounding secretin acetate today revolves around further understanding the complex role of hormones in mammals and how they interact with other systems of the body to control essential functions. (extremepeptides.com)
Much of how secretin acetate interacts with other hormones is still being learned, as is the effects of a deficit of this chemical on the body can affect an animal's overall health. (extremepeptides.com)

Sir I got provisional Secretin (SecreFlo)- FDA (1st dose certificate) instead of 2nd dose certificate. (food-planner.xyz)
Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control (but with adequate backup contraception, as drug interactions with birth control have not been conducted for secretin PAM) are permissible. (mayo.edu)
In contrast, the highest dose of PYY (0.62 pmol · kg -1 · min -1 ) had no significant influence on duodenal juice volume, output of bicarbonate, trypsin, or bilirubin during low dose stimulation with secretin (0.25 pmol · kg -1 · min -1 ) and cholecystokinin-8 (0.15 pmol · kg -1 · min -1 ). (elsevier.com)

The small intestine produces secretin when partially digested food from the stomach moves into the area. (medlineplus.gov)
S cells in the small intestine emit secretin. (bridgesfamilywellness.com)
The small intestine produces secretin wh. (adam.com)
These cells produce SECRETIN and are found in the MUCOSA of upper SMALL INTESTINE and PYLORIC ANTRUM in mammals. (bvsalud.org)

However, in recent years its efficacy has been questioned, and this new review of seven studies suggests that secretin is no more effective than placebo. (cnn.com)
The purpose of the study was to determine safety and efficacy of Secretin versus placebo in the treatment of Autism symptoms. (stephaniesarkis.com)
Unfortunately, the study results found that there was no difference in symptom change between children on Secretin and those on placebo. (stephaniesarkis.com)

This will inhibit the potentiation of secretin and the secretory response to this hormone. (extremepeptides.com)

A total of 105 chronic pancreatitis (CP), pancreatic cancer (PC), and nonpancreatic nonhealthy (patients with symptoms mimicking pancreatic disease but found to be free of any pancreatic disease) patients underwent endoscopic pancreatic juice collection after secretin stimulation. (nih.gov)

Human IgG antibody Laboratories manufactures the anti-rat secretin antibody ihc reagents distributed by Genprice. (kimgevaert.be)
The Anti-Rat Secretin Antibody Ihc reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (kimgevaert.be)
Description: The Secretin (Human) antibody is available in Europe and for worldwide shipping via Gentaur. (kimgevaert.be)

Clinical conditions in which patients present with hypergastrinemia, such as gastric outlet obstruction, pernicious anemia, renal failure, and achlorhydria due to atrophic gastritis, must be excluded with secretin provocative testing. (medscape.com)

Secretin-induced Duodenal Aspirate of Pancreatic Juice (SIDA): Utility of Commercial Genetic Analysis. (cdc.gov)
Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. (cdc.gov)

We have used immunocytochemical methods to characterize the spatial relationships of the serotonin-, secretin-, and substance P-containing enteroendocrine cell subsets in normal adult C57BL/6J x LT/Sv mice as well as in transgenic littermates that contain rat liver fatty acid-binding protein-human growth hormone fusion genes. (wustl.edu)
Our results reveal precise spatial interrelationships between these populations and suggest a differentiation pathway that may involve the sequential expression of substance P, serotonin, and secretin. (wustl.edu)

A new study reports brown fat interacts with secretin, a gut hormone, to signal the feeling of fullness to the brain while eating. (neurosciencenews.com)

The article 'A Systematic Review of Secretin for Children With Autism Spectrum Disorders' concludes that studying secretin as an autism treatment is no longer warranted. (cnn.com)

Similar molar basis reactions were observed when a vasoactive intestinal polypeptide was released instead of secretin. (extremepeptides.com)

If Zollinger-Ellison syndrome is strongly suspected and the secretin test result is negative, the test can either be repeated or a calcium stimulation test can be performed. (medscape.com)

Often asked: What Does Secretin Do In Digestion? (bridgesfamilywellness.com)

Over a decade ago, a report was published that described three children with autism showed improved behavior after being treated with secretin. (cnn.com)

Secretin has 3 main functions: regulation of gastric acid, regulation of pancreatic bicarbonate, and osmoregulation. (bridgesfamilywellness.com)

There is no need to alter the title of the cells since S can now stand for secretin instead of for small. (bmj.com)
Secretin also has been found in cells in the BRAIN and other tissues. (bvsalud.org)

Some secretin family GPCRs associate with receptor activity-modifying proteins (RAMPs), resulting in changes to receptor pharmacology. (nih.gov)

Thus, 1690, that an organ such as the thyroid secretin was the first hormone to be isolat- pours into the blood substances of physio- ed. (who.int)

Structure and dynamics of the active Gs-coupled human secretin receptor. (mpg.de)
PREFACE TO THE THIRD EDITION The scepticism with which many medical men formerly held off from the study of the internal secretions has been gradually replaced by the opposite tendency which, in many students of endocrinology, is exhibited as an en- deavor to interpret every change in the living human organism as a disturbance of the endocrine balance. (nih.gov)

In 1998 secretin, a gastrointestinal hormone, was suggested as an effective treatment for autism spectrum disorders (ASD) based on anecdotal evidence. (nih.gov)
The review finds no evidence that secretin therapy for autism is effective, and it does not recommend the treatment. (tadakaluri.com)
Secretin, he says, 'is one of the few areas where we feel we have solid high evidence. (cnn.com)

Anatomy4

Diseases7

Chemicals and Drugs13

Phenomena and Processes1

Information Science1

Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. (1/608)

COOH-terminally extended secretins are potent stimulants of pancreatic secretion. (2/608)

Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. (3/608)

Vagus nerve modulates secretin binding sites in the rat forestomach. (4/608)

Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. (5/608)

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. (6/608)

Duodenal acid-induced gastric relaxation is mediated by multiple pathways. (7/608)

Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor. (8/608)

Secretin

Receptors, Gastrointestinal Hormone

Pancreatic Juice

Cholecystokinin

Pancreas

Receptors, G-Protein-Coupled

Vasoactive Intestinal Peptide

Secretory Rate

Gastrointestinal Hormones

Hydrochloric Acid

Duodenum

Receptors, Vasoactive Intestinal Peptide

Bicarbonates

Gastrins

Amylases

Zollinger-Ellison Syndrome

Peptide PHI

Ceruletide

Gastric Juice

Carcinoid Tumor

Gastrointestinal Neoplasms

Appendiceal Neoplasms

Malignant Carcinoid Syndrome

Carcinoid Heart Disease

Ileal Neoplasms

Software

Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. (1/608)

COOH-terminally extended secretins are potent stimulants of pancreatic secretion. (2/608)

Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. (3/608)

Vagus nerve modulates secretin binding sites in the rat forestomach. (4/608)

Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. (5/608)

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. (6/608)

Duodenal acid-induced gastric relaxation is mediated by multiple pathways. (7/608)

Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor. (8/608)

Secretin stimulation test - Symptoms, Treatments and Resources for Secretin stimulation test

Analysis of Secretin-Induced Stress in Pseudomonas aeruginosa Suggests Prevention Rather than Response and Identifies a Novel...

Spatial Intensity Distribution Analysis Quantifies the Extent and Regulation of Homo-Dimerization of the Secretin Receptor |...

Secretin Provocation Test in the Diagnosis of Zollinger‐EIlison Syndrome<...

Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in...

Secretin Infusion for Pain Due to Chronic Pancreatitis - AdisInsight

Children with autistic spectrum disorders. I: Comparison of placebo and single dose of human synthetic secretin | Archives of...

Effect of exogenous cholecystokinin and secretin on pancreatic secretion of insulin and glucagon in rats.

Secretin - Wikipedia

Top Quality 99% CAS 170-34-35-4 Secretin Acetate For Hypothalamus - Wuhan Yuancheng Gongchuang Technology Co.Ltd - ecplaza.net

EFFECT OF GASTROINTESTINAL HORMONES, SECRETIN AND CHOLECYSTOKININ-PANCREOZYMIN, ON INSULIN AND GLUCAGON RELEASE IN HEALTHY AND...

Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors - Fingerprint -...

PDF] Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. | Semantic Scholar

SECRETIN, HUMAN (CAS 108153-74-8) Market Research Report 2018

Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand. | - CCMAR

Digestion - WikiEducator

Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. |...

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Pancreatic secretion, Digestive system module 6: accessory, By OpenStax (Page 2/26) | QuizOver.com

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Secretin Found Ineffective for Treating Autism | Quackwatch

Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone • Research -...

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Protein digestion in the stomach and small intestine