A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Renewal or physiological repair of damaged nerve tissue.
Treatment of muscles and nerves under pressure as a result of crush injuries.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Injuries to the PERIPHERAL NERVES.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.
A nerve originating in the lumbar spinal cord (usually L2 to L4) and traveling through the lumbar plexus to provide motor innervation to extensors of the thigh and sensory innervation to parts of the thigh, lower leg, and foot, and to the hip and knee joints.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
A major nerve of the upper extremity. In humans, the fibers of the median nerve originate in the lower cervical and upper thoracic spinal cord (usually C6 to T1), travel via the brachial plexus, and supply sensory and motor innervation to parts of the forearm and hand.
The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The resection or removal of the nerve to an organ or part. (Dorland, 28th ed)
Use of electric potential or currents to elicit biological responses.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
A chronic PELVIC PAIN characterized by pain deep in the buttock that may radiate to posterior aspects of the leg. It is caused by the piriformis muscle compressing or irritating the SCIATIC NERVE due to trauma, hypertrophy, inflammation or anatomic variations.
Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.
Neurons which activate MUSCLE CELLS.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
The lumbar and sacral plexuses taken together. The fibers of the lumbosacral plexus originate in the lumbar and upper sacral spinal cord (L1 to S3) and innervate the lower extremities.
The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.
A major nerve of the upper extremity. In humans the fibers of the radial nerve originate in the lower cervical and upper thoracic spinal cord (usually C5 to T1), travel via the posterior cord of the brachial plexus, and supply motor innervation to extensor muscles of the arm and cutaneous sensory fibers to extensor regions of the arm and hand.
Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A class of nerve fibers as defined by their nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small in diameter and usually several are surrounded by a single MYELIN SHEATH. They conduct low-velocity impulses, and represent the majority of peripheral sensory and autonomic fibers, but are also found in the BRAIN and SPINAL CORD.
Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.
A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
A branch of the trigeminal (5th cranial) nerve. The mandibular nerve carries motor fibers to the muscles of mastication and sensory fibers to the teeth and gingivae, the face in the region of the mandible, and parts of the dura.
A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.
The resection or removal of the innervation of a muscle or muscle tissue.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Application of a ligature to tie a vessel or strangulate a part.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.
The major nerves supplying sympathetic innervation to the abdomen. The greater, lesser, and lowest (or smallest) splanchnic nerves are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses. The lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.
A widely used local anesthetic agent.
The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A tumor made up of nerve cells and nerve fibers. (Dorland, 27th ed)
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect.
Amount of stimulation required before the sensation of pain is experienced.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.
The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The 11th cranial nerve which originates from NEURONS in the MEDULLA and in the CERVICAL SPINAL CORD. It has a cranial root, which joins the VAGUS NERVE (10th cranial) and sends motor fibers to the muscles of the LARYNX, and a spinal root, which sends motor fibers to the TRAPEZIUS and the sternocleidomastoid muscles.
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Surgical interruption of a spinal or cranial nerve root. (From Dorland, 28th ed)
Neoplasms which arise from nerve sheaths formed by SCHWANN CELLS in the PERIPHERAL NERVOUS SYSTEM or by OLIGODENDROCYTES in the CENTRAL NERVOUS SYSTEM. Malignant peripheral nerve sheath tumors, NEUROFIBROMA, and NEURILEMMOMA are relatively common tumors in this category.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
Traumatic injuries to the facial nerve. This may result in FACIAL PARALYSIS, decreased lacrimation and salivation, and loss of taste sensation in the anterior tongue. The nerve may regenerate and reform its original pattern of innervation, or regenerate aberrantly, resulting in inappropriate lacrimation in response to gustatory stimuli (e.g., "crocodile tears") and other syndromes.
Contractile tissue that produces movement in animals.
Act of eliciting a response from a person or organism through physical contact.
The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.
The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain.
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.
Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.
Blood vessels supplying the nerves.
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Branches of the vagus (tenth cranial) nerve. The recurrent laryngeal nerves originate more caudally than the superior laryngeal nerves and follow different paths on the right and left sides. They carry efferents to all muscles of the larynx except the cricothyroid and carry sensory and autonomic fibers to the laryngeal, pharyngeal, tracheal, and cardiac regions.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
A sensory branch of the MANDIBULAR NERVE, which is part of the trigeminal (5th cranial) nerve. The lingual nerve carries general afferent fibers from the anterior two-thirds of the tongue, the floor of the mouth, and the mandibular gingivae.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
Elements of limited time intervals, contributing to particular results or situations.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The observable response an animal makes to any situation.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
Either of two fleshy protuberances at the lower posterior section of the trunk or HIP in humans and primate on which a person or animal sits, consisting of gluteal MUSCLES and fat.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
The synapse between a neuron and a muscle.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
The intermediate sensory division of the trigeminal (5th cranial) nerve. The maxillary nerve carries general afferents from the intermediate region of the face including the lower eyelid, nose and upper lip, the maxillary teeth, and parts of the dura.
A voltage-gated sodium channel subtype that is expressed in nociceptors, including spinal and trigeminal sensory neurons. It plays a role in the transmission of pain signals induced by cold, heat, and mechanical stimuli.
A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.
The act of constricting.
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)
The outermost cytoplasmic layer of the SCHWANN CELLS covering NERVE FIBERS.
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. (1/2173)

Repetitive ectopic discharges from injured afferent nerves play an important role in initiation and maintenance of neuropathic pain. Gabapentin is effective for treatment of neuropathic pain but the sites and mechanisms of its antinociceptive actions remain uncertain. In the present study, we tested a hypothesis that therapeutic doses of gabapentin suppress ectopic afferent discharge activity generated from injured peripheral nerves. Mechanical allodynia, induced by partial ligation of the sciatic nerve in rats, was determined by application of von Frey filaments to the hindpaw. Single-unit afferent nerve activity was recorded proximal to the ligated sciatic nerve site. Intravenous gabapentin, in a range of 30 to 90 mg/kg, significantly attenuated allodynia in nerve-injured rats. Furthermore, gabapentin, in the same therapeutic dose range, dose-dependently inhibited the ectopic discharge activity of 15 injured sciatic afferent nerve fibers through an action on impulse generation. However, the conduction velocity and responses of 12 normal afferent fibers to mechanical stimulation were not affected by gabapentin. Therefore, this study provides electrophysiological evidence that gabapentin is capable of suppressing the ectopic discharge activity from injured peripheral nerves. This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain.  (+info)

Source of inappropriate receptive fields in cortical somatotopic maps from rats that sustained neonatal forelimb removal. (2/2173)

Previously this laboratory demonstrated that forelimb removal at birth in rats results in the invasion of the cuneate nucleus by sciatic nerve axons and the development of cuneothalamic cells with receptive fields that include both the forelimb-stump and the hindlimb. However, unit-cluster recordings from primary somatosensory cortex (SI) of these animals revealed few sites in the forelimb-stump representation where responses to hindlimb stimulation also could be recorded. Recently we reported that hindlimb inputs to the SI forelimb-stump representation are suppressed functionally in neonatally amputated rats and that GABAergic inhibition is involved in this process. The present study was undertaken to assess the role that intracortical projections from the SI hindlimb representation may play in the functional reorganization of the SI forelimb-stump field in these animals. The SI forelimb-stump representation was mapped during gamma-aminobutyric acid (GABA)-receptor blockade, both before and after electrolytic destruction of the SI hindlimb representation. Analysis of eight amputated rats showed that 75.8% of 264 stump recording sites possessed hindlimb receptive fields before destruction of the SI hindlimb. After the lesions, significantly fewer sites (13.2% of 197) were responsive to hindlimb stimulation (P < 0.0001). Electrolytic destruction of the SI lower-jaw representation in four additional control rats with neonatal forelimb amputation did not significantly reduce the percentage of hindlimb-responsive sites in the SI stump field during GABA-receptor blockade (P = 0.98). Similar results were obtained from three manipulated rats in which the SI hindlimb representation was silenced temporarily with a local cobalt chloride injection. Analysis of response latencies to sciatic nerve stimulation in the hindlimb and forelimb-stump representations suggested that the intracortical pathway(s) mediating the hindlimb responses in the forelimb-stump field may be polysynaptic. The mean latency to sciatic nerve stimulation at responsive sites in the GABA-receptor blocked SI stump representation of neonatally amputated rats was significantly longer than that for recording sites in the hindlimb representation [26.3 +/- 8.1 (SD) ms vs. 10.8 +/- 2.4 ms, respectively, P < 0.0001]. These results suggest that hindlimb input to the SI forelimb-stump representation detected in GABA-blocked cortices of neonatally forelimb amputated rats originates primarily from the SI hindlimb representation.  (+info)

Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. (3/2173)

1. Immunocytochemistry with polyclonal antibodies directed against specific fragments of intracellular loops of alpha2A- and alpha2C-adrenergic receptors (alpha2A-AR, alpha2C-AR) was used to explore the possibility that expression of these receptors in dorsal root ganglion (DRG) neurones of rat alters as a result of peripheral nerve injury or localized inflammation. 2. Small numbers of neurones with positive alpha2A-AR immunoreactivity (alpha2A-AR-IR) were detected in DRG from normal animals or contralateral to nerve lesions. In contrast, after complete or partial sciatic nerve transection the numbers of ipsilateral L4 and L5 DRG somata expressing alpha2A-AR-IR sharply increased (>5-fold). There was no discernible change in the number of DRG neurones exhibiting alpha2A-AR-IR innervating a region in association with localized chemically induced inflammation. 3. After nerve injury, double labelling with Fluoro-Gold, a marker of retrograde transport from transected fibres, or by immunoreactivity for c-jun protein, an indicator of injury and regeneration, suggested that many of the neurones expressing alpha2A-AR-IR were uninjured by the sciatic lesions. 4. In general the largest proportionate increase in numbers of neurones labelled by alpha2A-AR-IR after nerve lesions appeared in the medium-large diameter range (31-40 microm), a group principally composed of cell bodies of low threshold mechanoreceptors. The number of small diameter DRG neurones labelled by alpha2A-AR-IR, a category likely to include somata of nociceptors, also increased but proportionately less. 5. Relatively few DRG neurones exhibited alpha2C-AR-IR; this population did not appear to change after either nerve lesions or inflammation. 6. These observations are considered in relation to effects of nerve injury on excitation of primary afferent neurones by sympathetic activity or adrenergic agents, sympathetically related neuropathy and reports of sprouting of sympathetic fibres in DRG.  (+info)

Hypothermic neuroprotection of peripheral nerve of rats from ischaemia-reperfusion injury. (4/2173)

Although there is much information on experimental ischaemic neuropathy, there are only scant data on neuroprotection. We evaluated the effectiveness of hypothermia in protecting peripheral nerve from ischaemia-reperfusion injury using the model of experimental nerve ischaemia. Forty-eight male Sprague-Dawley rats were divided into six groups. We used a ligation-reperfusion model of nerve ischaemia where each of the supplying arteries to the sciatic-tibial nerves of the right hind limb was ligated and the ligatures were released after a predetermined period of ischaemia. The right hind limbs of one group (24 rats) were made ischaemic for 5 h and those of the other group (24 rats) for 3 h. Each group was further divided into three and the limbs were maintained at 37 degrees C (36 degrees C for 5 h of ischaemia) in one, 32 degrees C in the second and 28 degrees C in the third of these groups for the final 2 h of the ischaemic period and an additional 2 h of the reperfusion period. A behavioural score was recorded and nerve electrophysiology of motor and sensory nerves was undertaken 1 week after surgical procedures. At that time, entire sciatic-tibial nerves were harvested and fixed in situ. Four portions of each nerve were examined: proximal sciatic nerve, distal sciatic nerve, mid-tibial nerve and distal tibial nerve. To determine the degree of fibre degeneration, each section was studied by light microscopy, and we estimated an oedema index and a fibre degeneration index. The groups treated at 36-37 degrees C underwent marked fibre degeneration, associated with a reduction in action potential and impairment in behavioural score. The groups treated at 28 degrees C (for both 3 and 5 h) showed significantly less (P < 0.01; ANOVA, Bonferoni post hoc test) reperfusion injury for all indices (behavioural score, electrophysiology and neuropathology), and the groups treated at 32 degrees C had scores intermediate between the groups treated at 36-37 degrees C and 28 degrees C. Our results showed that cooling the limbs dramatically protects the peripheral nerve from ischaemia-reperfusion injury.  (+info)

Injury-induced gelatinase and thrombin-like activities in regenerating and nonregenerating nervous systems. (5/2173)

It is now widely accepted that injured nerves, like any other injured tissue, need assistance from their extracellular milieu in order to heal. We compared the postinjury activities of thrombin and gelatinases, two types of proteolytic activities known to be critically involved in tissue healing, in nonregenerative (rat optic nerve) and regenerative (fish optic nerve and rat sciatic nerve) neural tissue. Unlike gelatinases, whose induction pattern was comparable in all three nerves, thrombin-like activity differed clearly between regenerating and nonregenerating nervous systems. Postinjury levels of this latter activity seem to dictate whether it will display beneficial or detrimental effects on the capacity of the tissue for repair. The results of this study further highlight the fact that tissue repair and nerve regeneration are closely linked and that substances that are not unique to the nervous system, but participate in wound healing in general, are also crucial for regeneration or its failure in the nervous system.  (+info)

A role for insulin-like growth factor-I in the regulation of Schwann cell survival. (6/2173)

During postnatal development in the peripheral nerve, differentiating Schwann cells are susceptible to apoptotic death. Schwann cell apoptosis is regulated by axons and serves as one mechanism through which axon and Schwann cell numbers are correctly matched. This regulation is mediated in part by the provision of limiting axon-derived trophic molecules, although neuregulin-1 (NRG-1) is the only trophic factor shown to date to support Schwann cell survival. In this report, we identify insulin-like growth factor-I (IGF-I) as an additional trophin that can promote Schwann cell survival in vitro. We find that IGF-I, like NRG-1, can prevent the apoptotic death of postnatal rat Schwann cells cultured under conditions of serum withdrawal. Moreover, we show that differentiating Schwann cells in the rat sciatic nerve express both the IGF-I receptor (IGF-I R) and IGF-I throughout postnatal development. These results indicate that IGF-I is likely to control Schwann cell viability in the developing peripheral nerve and, together with other findings, raise the interesting possibility that such survival regulation may switch during postnatal development from an axon-dependent mechanism to an autocrine and/or paracrine one.  (+info)

Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. (7/2173)

The transcription factors Krox-20 and SCIP each play important roles in the differentiation of Schwann cells. However, the genes encoding these two proteins exhibit distinct time courses of expression and yield distinct cellular phenotypes upon mutation. SCIP is expressed prior to the initial appearance of Krox-20, and is transient in both the myelinating and non-myelinating Schwann cell lineages; while in contrast, Krox-20 appears approximately 24 hours after SCIP and then only within the myelinating lineage, where its expression is stably maintained into adulthood. Similarly, differentiation of SCIP-/- Schwann cells appears to transiently stall at the promyelinating stage that precedes myelination, whereas Krox-20(-/-) cells are, by morphological criteria, arrested at this stage. These observations led us to examine SCIP regulation and Schwann cell phenotype in Krox-20 mouse mutants. We find that in Krox-20(-/-) Schwann cells, SCIP expression is converted from transient to sustained. We further observe that both Schwann cell proliferation and apoptosis, which are normal features of SCIP+ cells, are also markedly increased late in postnatal development in Krox-20 mutants relative to wild type, and that the levels of cell division and apoptosis are balanced to yield a stable number of Schwann cells within peripheral nerves. These data demonstrate that the loss of Krox-20 in myelinating Schwann cells arrests differentiation at the promyelinating stage, as assessed by SCIP expression, mitotic activity and susceptibility to apoptosis.  (+info)

Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods. (8/2173)

AIM: To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats. METHODS: Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1). Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d, 2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart, diaphragm, small intestine, and kidney after 8 months of diabetes were measured. RESULTS: Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1), hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in lens and sciatic nerve increased in normal and diabetic rats; the increase was higher in diabetic rats. No relationship was shown between glycemia and sorbitol levels. An increased sorbitol level after 8 months of diabetes was found in small intestine and kidney. CONCLUSION: The sorbitol levels increased in lens and sciatic nerve with aging and this process was accelerated by diabetes.  (+info)

Types of Peripheral Nerve Injuries:

1. Traumatic Nerve Injury: This type of injury occurs due to direct trauma to the nerve, such as a blow or a crush injury.
2. Compression Neuropathy: This type of injury occurs when a nerve is compressed or pinched, leading to damage or disruption of the nerve signal.
3. Stretch Injury: This type of injury occurs when a nerve is stretched or overstretched, leading to damage or disruption of the nerve signal.
4. Entrapment Neuropathy: This type of injury occurs when a nerve is compressed or trapped between two structures, leading to damage or disruption of the nerve signal.

Symptoms of Peripheral Nerve Injuries:

1. Weakness or paralysis of specific muscle groups
2. Numbness or tingling in the affected area
3. Pain or burning sensation in the affected area
4. Difficulty with balance and coordination
5. Abnormal reflexes
6. Incontinence or other bladder or bowel problems

Causes of Peripheral Nerve Injuries:

1. Trauma, such as a car accident or fall
2. Sports injuries
3. Repetitive strain injuries, such as those caused by repetitive motions in the workplace or during sports activities
4. Compression or entrapment of nerves, such as carpal tunnel syndrome or tarsal tunnel syndrome
5. Infections, such as Lyme disease or diphtheria
6. Tumors or cysts that compress or damage nerves
7. Vitamin deficiencies, such as vitamin B12 deficiency
8. Autoimmune disorders, such as rheumatoid arthritis or lupus
9. Toxins, such as heavy metals or certain chemicals

Treatment of Peripheral Nerve Injuries:

1. Physical therapy to improve strength and range of motion
2. Medications to manage pain and inflammation
3. Surgery to release compressed nerves or repair damaged nerves
4. Electrical stimulation therapy to promote nerve regeneration
5. Platelet-rich plasma (PRP) therapy to stimulate healing
6. Stem cell therapy to promote nerve regeneration
7. Injection of botulinum toxin to relieve pain and reduce muscle spasticity
8. Orthotics or assistive devices to improve mobility and function

It is important to seek medical attention if you experience any symptoms of a peripheral nerve injury, as early diagnosis and treatment can help prevent long-term damage and improve outcomes.

There are several types of nerve compression syndromes, including:

1. Carpal tunnel syndrome: Compression of the median nerve in the wrist, commonly caused by repetitive motion or injury.
2. Tarsal tunnel syndrome: Compression of the posterior tibial nerve in the ankle, similar to carpal tunnel syndrome but affecting the lower leg.
3. Cubital tunnel syndrome: Compression of the ulnar nerve at the elbow, often caused by repetitive leaning or bending.
4. Thoracic outlet syndrome: Compression of the nerves and blood vessels that pass through the thoracic outlet (the space between the neck and shoulder), often caused by poor posture or injury.
5. Peripheral neuropathy: A broader term for damage to the peripheral nerves, often caused by diabetes, vitamin deficiencies, or other systemic conditions.
6. Meralgia paresthetica: Compression of the lateral femoral cutaneous nerve in the thigh, commonly caused by direct trauma or compression from a tight waistband or clothing.
7. Morton's neuroma: Compression of the plantar digital nerves between the toes, often caused by poorly fitting shoes or repetitive stress on the feet.
8. Neuralgia: A general term for pain or numbness caused by damage or irritation to a nerve, often associated with chronic conditions such as shingles or postherpetic neuralgia.
9. Trigeminal neuralgia: A condition characterized by recurring episodes of sudden, extreme pain in the face, often caused by compression or irritation of the trigeminal nerve.
10. Neuropathic pain: Pain that occurs as a result of damage or dysfunction of the nervous system, often accompanied by other symptoms such as numbness, tingling, or weakness.

Neuralgia is often difficult to diagnose and treat, as the underlying cause can be challenging to identify. However, various medications and therapies can help manage the pain and other symptoms associated with this condition. These may include pain relievers, anticonvulsants, antidepressants, and muscle relaxants, as well as alternative therapies such as acupuncture or physical therapy.

Some common forms of neuralgia include:

1. Trigeminal neuralgia: This is a condition that affects the trigeminal nerve, which carries sensation from the face to the brain. It is characterized by sudden, intense pain in the face, typically on one side.
2. Postherpetic neuralgia (PHN): This is a condition that occurs after a shingles infection, and is characterized by persistent pain in the affected area.
3. Occipital neuralgia: This is a condition that affects the nerves in the back of the head and neck, and can cause pain in the back of the head, neck, and face.
4. Geniculate neuralgia: This is a rare condition that affects the nerves in the jaw and ear, and can cause pain in the jaw, face, and ear.

Overall, neuralgia is a complex and debilitating condition that can significantly impact an individual's quality of life. It is important for individuals experiencing symptoms of neuralgia to seek medical attention to determine the underlying cause and develop an appropriate treatment plan.

Hyperalgesia is often seen in people with chronic pain conditions, such as fibromyalgia, and it can also be a side effect of certain medications or medical procedures. Treatment options for hyperalgesia depend on the underlying cause of the condition, but may include pain management techniques, physical therapy, and medication adjustments.

In clinical settings, hyperalgesia is often assessed using a pinprick test or other pain tolerance tests to determine the patient's sensitivity to different types of stimuli. The goal of treatment is to reduce the patient's pain and improve their quality of life.

Peripheral Nervous System Diseases can result from a variety of causes, including:

1. Trauma or injury
2. Infections such as Lyme disease or HIV
3. Autoimmune disorders such as Guillain-Barré syndrome
4. Genetic mutations
5. Tumors or cysts
6. Toxins or poisoning
7. Vitamin deficiencies
8. Chronic diseases such as diabetes or alcoholism

Some common Peripheral Nervous System Diseases include:

1. Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
2. Multiple Sclerosis (MS) - an autoimmune disease that affects the CNS and PNS, causing a range of symptoms including numbness, weakness, and vision problems.
3. Peripheral Neuropathy - damage to the nerves that can cause pain, numbness, and weakness in the affected areas.
4. Guillain-Barré syndrome - an autoimmune disorder that causes muscle weakness and paralysis.
5. Charcot-Marie-Tooth disease - a group of inherited disorders that affect the nerves in the feet and legs, leading to muscle weakness and wasting.
6. Friedreich's ataxia - an inherited disorder that affects the nerves in the spine and limbs, leading to coordination problems and muscle weakness.
7. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - an autoimmune disorder that causes inflammation of the nerves, leading to pain, numbness, and weakness in the affected areas.
8. Amyotrophic Lateral Sclerosis (ALS) - a progressive neurological disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, atrophy, and paralysis.
9. Spinal Muscular Atrophy - an inherited disorder that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.
10. Muscular Dystrophy - a group of inherited disorders that affect the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness and wasting.

It's important to note that this is not an exhaustive list and there may be other causes of muscle weakness. If you are experiencing persistent or severe muscle weakness, it is important to see a healthcare professional for proper evaluation and diagnosis.

The process of Wallerian degeneration begins with the loss of myelin sheaths that surround the axons and are essential for their proper functioning. As a result of this degeneration, the axoplasm (the cytoplasmic contents of an axon) is exposed to the extracellular space, leading to a series of degradative changes within the axon. These changes include:

1. Breakdown of organelles and their membranes
2. Release of cellular contents into the extracellular space
3. Activation of proteolytic enzymes that degrade axonal structures
4. Influx of ionic fluids and water into the axon, leading to swelling and eventually rupture of the axon.

The onset and progression of Wallerian degeneration depend on various factors, including the severity of the initial injury, the age of the individual, and the presence of any underlying medical conditions. The degenerative process can be slowed down or even halted by various interventions, such as local application of neurotrophic factors or axonal regeneration promoters.

Wallerian degeneration is a common phenomenon in many neurodegenerative diseases and injuries, including traumatic brain injury, multiple sclerosis, and peripheral nerve damage. Understanding the mechanisms of Wallerian degeneration can provide valuable insights into the pathogenesis of these conditions and may lead to the development of novel therapeutic strategies for their management.

There are several types of diabetic neuropathies, including:

1. Peripheral neuropathy: This is the most common type of diabetic neuropathy and affects the nerves in the hands and feet. It can cause numbness, tingling, and pain in these areas.
2. Autonomic neuropathy: This type of neuropathy affects the nerves that control involuntary functions, such as digestion, bladder function, and blood pressure. It can cause a range of symptoms, including constipation, diarrhea, urinary incontinence, and sexual dysfunction.
3. Proximal neuropathy: This type of neuropathy affects the nerves in the legs and hips. It can cause weakness, pain, and stiffness in these areas.
4. Focal neuropathy: This type of neuropathy affects a single nerve, often causing sudden and severe pain.

The exact cause of diabetic neuropathies is not fully understood, but it is thought to be related to high blood sugar levels over time. Other risk factors include poor blood sugar control, obesity, smoking, and alcohol consumption. There is no cure for diabetic neuropathy, but there are several treatments available to manage the symptoms and prevent further nerve damage. These treatments may include medications, physical therapy, and lifestyle changes such as regular exercise and a healthy diet.

The most common cause of sciatica is a herniated disc, which occurs when the gel-like center of a spinal disc bulges out through a tear in the outer disc. This can put pressure on the sciatic nerve and cause pain and other symptoms. Other possible causes of sciatica include spondylolisthesis (a condition in which a vertebra slips out of place), spinal stenosis (narrowing of the spinal canal), and piriformis syndrome (compression of the sciatic nerve by the piriformis muscle).

Treatment for sciatica depends on the underlying cause of the symptoms. Conservative treatments such as physical therapy, pain medication, and anti-inflammatory medications are often effective in managing symptoms. In some cases, surgery may be necessary to relieve compression on the sciatic nerve.

The term "sciatica" is derived from the Latin word "sciare," which means "to shoot." This refers to the shooting pain that can occur in the lower back and legs when the sciatic nerve is compressed or irritated.

Peripheral nervous system neoplasms can arise in various parts of the PNS, including:

1. Nerve sheath (Schwann cells): These tumors are called schwannomas or neurilemmomas.
2. Perineural tissue (perineurial cells): These tumors are called perineuriomas.
3. Nerve fibers (neurons): These tumors are called neurofibromas or nerve sheath tumors.
4. Miscellaneous (other types of cells): These tumors are called miscellaneous peripheral nervous system neoplasms.

Some common symptoms of peripheral nervous system neoplasms include:

* Painless lumps or masses in the neck, arm, or leg
* Weakness or numbness in the affected limb
* Tingling or burning sensations in the affected area
* Difficulty with coordination and balance
* Problems with vision or hearing

Peripheral nervous system neoplasms can be diagnosed through a variety of tests, including:

1. Imaging studies (MRI, CT scan, PET scan) to visualize the tumor and determine its location and size.
2. Biopsy to collect a tissue sample for further examination under a microscope.
3. Electromyography (EMG) to test the function of the nerves and muscles.
4. Genetic testing to look for specific genetic changes that may be associated with the tumor.

Treatment options for peripheral nervous system neoplasms depend on the type, size, location, and aggressiveness of the tumor, as well as the patient's overall health and preferences. Some common treatment options include:

1. Surgery to remove the tumor and any affected tissue.
2. Radiation therapy to kill cancer cells and shrink the tumor.
3. Chemotherapy to destroy cancer cells throughout the body.
4. Targeted therapy to specifically target cancer cells with drugs or other substances.
5. Observation and monitoring, as some peripheral nervous system neoplasms may be slow-growing and may not require immediate treatment.

It's important for individuals to seek medical attention if they experience any symptoms that may indicate a peripheral nervous system neoplasm. Early diagnosis and treatment can improve outcomes and increase the chances of successful treatment.

Example sentences:

1. The patient was diagnosed with piriformis muscle syndrome after complaining of pain in her legs and difficulty walking.
2. The doctor recommended physical therapy to treat the piriformis muscle syndrome and relieve the compression on the sciatic nerve.
3. After a few weeks of stretching exercises and massage therapy, the patient experienced significant improvement in her symptoms and was able to resume normal activities.

Types of Hyperesthesia:

1. Allodynia: This type of hyperesthesia is characterized by pain from light touch or contact that would normally not cause pain.
2. Hyperalgesia: This condition is marked by an increased sensitivity to pain, such as a severe response to mild stimuli.
3. Hyperpathia: It is characterized by an abnormal increase in sensitivity to tactile stimulation, such as feeling pain from gentle touch or clothing.
4. Thermal hyperalgesia: This condition is marked by an increased sensitivity to heat or cold temperatures.

Causes of Hyperesthesia:

1. Neurological disorders: Conditions such as migraines, multiple sclerosis, peripheral neuropathy, and stroke can cause hyperesthesia.
2. Injuries: Traumatic injuries, such as nerve damage or spinal cord injuries, can lead to hyperesthesia.
3. Infections: Certain infections, such as shingles or Lyme disease, can cause hyperesthesia.
4. Medications: Certain medications, such as antidepressants or chemotherapy drugs, can cause hyperesthesia as a side effect.
5. Other causes: Hyperesthesia can also be caused by other medical conditions, such as skin disorders or hormonal imbalances.

Symptoms of Hyperesthesia:

1. Pain or discomfort from light touch or contact
2. Increased sensitivity to temperature changes
3. Burning or stinging sensations
4. Itching or tingling sensations
5. Abnormal skin sensations, such as crawling or tingling
6. Sensitivity to sounds or lights
7. Difficulty with fine motor skills or hand-eye coordination
8. Mood changes, such as anxiety or depression
9. Fatigue or lethargy
10. Cognitive impairment or difficulty concentrating.

Diagnosis of Hyperesthesia:

To diagnose hyperesthesia, a healthcare provider will typically begin with a physical examination and medical history. They may also conduct tests to rule out other conditions that could be causing the symptoms. These tests may include:

1. Blood tests: To check for infections or hormonal imbalances
2. Imaging tests: Such as X-rays, CT scans, or MRI scans to look for nerve damage or other conditions
3. Nerve conduction studies: To test the function of nerves
4. Electromyography (EMG): To test muscle activity and nerve function.
5. Skin biopsy: To examine the skin tissue for signs of skin disorders.

Treatment of Hyperesthesia:

The treatment of hyperesthesia will depend on the underlying cause of the condition. In some cases, the symptoms may be managed with medication or lifestyle changes. Some possible treatments include:

1. Pain relief medications: Such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain and reduce inflammation.
2. Anti-seizure medications: To control seizures in cases of epilepsy.
3. Antidepressant medications: To manage depression or anxiety related to the condition.
4. Physical therapy: To improve mobility and strength, and to reduce stiffness and pain.
5. Occupational therapy: To help with daily activities and to improve fine motor skills.
6. Lifestyle changes: Such as avoiding triggers, taking regular breaks to rest, and practicing stress-reducing techniques such as meditation or deep breathing.
7. Alternative therapies: Such as acupuncture or massage therapy may also be helpful in managing symptoms.

It is important to note that the treatment of hyperesthesia is highly individualized and may take some trial and error to find the most effective combination of treatments. It is best to work with a healthcare provider to determine the best course of treatment for your specific case.

There are many different types of nerve degeneration that can occur in various parts of the body, including:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function, leading to degeneration of brain cells.
2. Parkinson's disease: A neurodegenerative disorder that affects movement and balance, caused by the loss of dopamine-producing neurons in the brain.
3. Amyotrophic lateral sclerosis (ALS): A progressive neurological disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death.
4. Multiple sclerosis: An autoimmune disease that affects the central nervous system, causing inflammation and damage to nerve fibers.
5. Diabetic neuropathy: A complication of diabetes that can cause damage to nerves in the hands and feet, leading to pain, numbness, and weakness.
6. Guillain-Barré syndrome: An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and paralysis.
7. Chronic inflammatory demyelinating polyneuropathy (CIDP): An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and numbness.

The causes of nerve degeneration are not always known or fully understood, but some possible causes include:

1. Genetics: Some types of nerve degeneration may be inherited from one's parents.
2. Aging: As we age, our nerve cells can become damaged or degenerate, leading to a decline in cognitive and physical function.
3. Injury or trauma: Physical injury or trauma to the nervous system can cause nerve damage and degeneration.
4. Infections: Certain infections, such as viral or bacterial infections, can cause nerve damage and degeneration.
5. Autoimmune disorders: Conditions such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP) are caused by the immune system attacking and damaging nerve cells.
6. Toxins: Exposure to certain toxins, such as heavy metals or pesticides, can damage and degenerate nerve cells.
7. Poor nutrition: A diet that is deficient in essential nutrients, such as vitamin B12 or other B vitamins, can lead to nerve damage and degeneration.
8. Alcoholism: Long-term alcohol abuse can cause nerve damage and degeneration due to the toxic effects of alcohol on nerve cells.
9. Drug use: Certain drugs, such as chemotherapy drugs and antiviral medications, can damage and degenerate nerve cells.
10. Aging: As we age, our nerve cells can deteriorate and become less functional, leading to a range of cognitive and motor symptoms.

It's important to note that in some cases, nerve damage and degeneration may be irreversible, but there are often strategies that can help manage symptoms and improve quality of life. If you suspect you have nerve damage or degeneration, it's important to seek medical attention as soon as possible to receive an accurate diagnosis and appropriate treatment.

The symptoms of neuritis can vary depending on the specific nerve affected and the severity of the inflammation. Some common symptoms include:

* Pain along the course of the affected nerve
* Numbness or tingling in the affected area
* Weakness or muscle wasting in the affected muscles
* Difficulty moving or controlling the affected limbs
* Sensory loss or altered sensation in the affected area

Neuritis can affect any nerve in the body, but it is most common in the:

* Peripheral nerves (nerves that connect the brain and spinal cord to the rest of the body)
* Optic nerve (which carries visual information from the eye to the brain)
* Auditory nerve (which carries sound information from the inner ear to the brain)
* Spinal nerves (which run down the spine and carry sensory information to and from the brain)

Treatment of neuritis depends on the underlying cause and the severity of the condition. It may involve medications such as pain relievers, anti-inflammatory drugs, or corticosteroids, as well as physical therapy and lifestyle modifications to manage symptoms and promote healing. In some cases, surgery may be necessary to relieve compression or damage to the affected nerve.

Preventive measures for neuritis include:

* Maintaining a healthy lifestyle, including regular exercise, a balanced diet, and adequate sleep
* Avoiding exposure to toxins or other harmful substances that can damage nerves
* Managing chronic conditions such as diabetes, autoimmune disorders, or infections that can increase the risk of neuritis.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are several different types of pain, including:

1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.

The medical field uses a range of methods to assess and manage pain, including:

1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.

It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.

The term "neuroma" is derived from the Greek words "neuron," meaning nerve, and "oma," meaning tumor. It is also known as a neurilemmoma, which refers to the layer of connective tissue that surrounds the nerve. Neuromas are usually slow-growing and may not cause any symptoms in their early stages. However, they can cause pain, numbness, and tingling in the affected area as they grow larger.

There are several types of neuroma, including:

* Morton's neuroma: This is the most common type of neuroma and affects the nerve that runs between the third and fourth toes. It is caused by compression or irritation of the nerve and can be treated with conservative methods such as shoe inserts, physical therapy, and anti-inflammatory medications.
* Plantar neuroectodermal tumor: This type of neuroma occurs on the sole of the foot and is more rare than Morton's neuroma. It can be treated with surgery or radiation therapy.
* Acoustic neuroma: This type of neuroma affects the nerve that connects the inner ear to the brain and is usually benign. It can cause hearing loss, balance problems, and tinnitus (ringing in the ears).

In summary, a neuroma is a benign tumor that grows on a nerve, typically found between the third and fourth toes. It can cause pain, numbness, and tingling in the affected area and may be treated with surgery or other methods. There are several types of neuroma, including Morton's neuroma, plantar neuroectodermal tumor, and acoustic neuroma.

Types of Optic Nerve Injuries:

1. Traumatic optic neuropathy: This type of injury is caused by direct damage to the optic nerve as a result of trauma, such as a car accident or sports injury.
2. Ischemic optic neuropathy: This type of injury is caused by a lack of blood flow to the optic nerve, which can lead to cell death and vision loss.
3. Inflammatory optic neuropathy: This type of injury is caused by inflammation of the optic nerve, which can be caused by conditions such as multiple sclerosis or sarcoidosis.
4. Tumor-induced optic neuropathy: This type of injury is caused by a tumor that compresses or damages the optic nerve.
5. Congenital optic nerve disorders: These are present at birth and can cause vision loss or blindness. Examples include optic nerve hypoplasia and coloboma.

Symptoms of Optic Nerve Injuries:

* Blurred vision or double vision
* Loss of peripheral vision
* Difficulty seeing in dim lighting
* Pain or discomfort in the eye or head
* Redness or swelling of the eye

Diagnosis and Treatment of Optic Nerve Injuries:

Diagnosis is typically made through a combination of physical examination, imaging tests such as MRI or CT scans, and visual field testing. Treatment depends on the underlying cause of the injury, but may include medication, surgery, or vision rehabilitation. In some cases, vision loss may be permanent, but early diagnosis and treatment can help to minimize the extent of the damage.

Prognosis for Optic Nerve Injuries:

The prognosis for optic nerve injuries varies depending on the underlying cause and severity of the injury. In some cases, vision may be partially or fully restored with treatment. However, in other cases, vision loss may be permanent. It is important to seek medical attention immediately if any symptoms of an optic nerve injury are present, as early diagnosis and treatment can improve outcomes.

The most common demyelinating diseases include:

1. Multiple sclerosis (MS): An autoimmune disease that affects the CNS, including the brain, spinal cord, and optic nerves. MS causes inflammation and damage to the myelin sheath, leading to a range of symptoms such as muscle weakness, vision problems, and cognitive difficulties.
2. Acute demyelination: A sudden, severe loss of myelin that can be caused by infections, autoimmune disorders, or other factors. This condition can result in temporary or permanent nerve damage.
3. Chronic inflammatory demyelination (CIDP): A rare autoimmune disorder that causes progressive damage to the myelin sheath over time. CIDP can affect the CNS and the peripheral nervous system (PNS).
4. Moore's disease: A rare genetic disorder that results in progressive demyelination of the CNS, leading to a range of neurological symptoms including muscle weakness, seizures, and cognitive difficulties.
5. Leukodystrophies: A group of genetic disorders that affect the development or function of myelin-producing cells in the CNS. These conditions can cause progressive loss of myelin and result in a range of neurological symptoms.

Demyelinating diseases can be challenging to diagnose, as the symptoms can be similar to other conditions and the disease progression can be unpredictable. Treatment options vary depending on the specific condition and its severity, and may include medications to reduce inflammation and modulate the immune system, as well as rehabilitation therapies to help manage symptoms and improve quality of life.

Types of Experimental Diabetes Mellitus include:

1. Streptozotocin-induced diabetes: This type of EDM is caused by administration of streptozotocin, a chemical that damages the insulin-producing beta cells in the pancreas, leading to high blood sugar levels.
2. Alloxan-induced diabetes: This type of EDM is caused by administration of alloxan, a chemical that also damages the insulin-producing beta cells in the pancreas.
3. Pancreatectomy-induced diabetes: In this type of EDM, the pancreas is surgically removed or damaged, leading to loss of insulin production and high blood sugar levels.

Experimental Diabetes Mellitus has several applications in research, including:

1. Testing new drugs and therapies for diabetes treatment: EDM allows researchers to evaluate the effectiveness of new treatments on blood sugar control and other physiological processes.
2. Studying the pathophysiology of diabetes: By inducing EDM in animals, researchers can study the progression of diabetes and its effects on various organs and tissues.
3. Investigating the role of genetics in diabetes: Researchers can use EDM to study the effects of genetic mutations on diabetes development and progression.
4. Evaluating the efficacy of new diagnostic techniques: EDM allows researchers to test new methods for diagnosing diabetes and monitoring blood sugar levels.
5. Investigating the complications of diabetes: By inducing EDM in animals, researchers can study the development of complications such as retinopathy, nephropathy, and cardiovascular disease.

In conclusion, Experimental Diabetes Mellitus is a valuable tool for researchers studying diabetes and its complications. The technique allows for precise control over blood sugar levels and has numerous applications in testing new treatments, studying the pathophysiology of diabetes, investigating the role of genetics, evaluating new diagnostic techniques, and investigating complications.

In NAE, the immune system mistakenly attacks the nerves, leading to inflammation and damage. This can cause a range of symptoms, including pain, numbness, tingling, and weakness in the affected area. The condition is often triggered by exposure to certain environmental factors or by a genetic predisposition.

Some of the key features of NAE include:

* Inflammation of the nerves: The immune system releases chemicals that cause inflammation in the nerves, leading to damage and disruption of normal nerve function.
* Nerve damage: The inflammation can cause damage to the nerves, leading to a loss of function and potentially permanent damage.
* Pain: One of the most common symptoms of NAE is pain in the affected area. This can range from mild to severe and can be persistent or intermittent.
* Numbness and tingling: The inflammation can also cause numbness and tingling sensations in the affected area.
* Weakness: In some cases, NAE can cause weakness or paralysis of the muscles in the affected area.

There is currently no cure for NAE, but various treatments are being studied to manage its symptoms and slow its progression. These include medications to reduce inflammation and modulate the immune response, as well as physical therapy and lifestyle modifications.

Nerve sheath neoplasms are usually slow-growing and may not cause any symptoms in the early stages. However, as they grow, they can exert pressure on the surrounding nerve tissue and cause a variety of symptoms, including:

1. Pain or numbness in the affected area
2. Weakness or paralysis of the muscles served by the affected nerve
3. Tingling or burning sensations in the skin or extremities
4. Seizures, in rare cases

The exact cause of nerve sheath neoplasms is not known, but they are thought to be associated with genetic mutations that affect the development and growth of nerve cells. Some cases may also be caused by inherited conditions, such as Neurofibromatosis type 1 (NF1) or schwannomatosis.

There are several types of nerve sheath neoplasms, including:

1. Neurofibromas: These are the most common type of nerve sheath tumor and are usually benign. They can occur in any part of the body and may grow slowly over time.
2. Schwannomas: These are also benign tumors that arise from the covering of nerves (the schwann cells). They are usually slow-growing and can occur in any part of the body.
3. Malignant peripheral nerve sheath tumors (MPNSTs): These are rare and aggressive tumors that can arise from the coverings of nerves. They can grow rapidly and can be difficult to treat.

Diagnosis of nerve sheath neoplasms typically involves a combination of imaging studies, such as MRI or CT scans, and a biopsy to confirm the presence of a tumor. Treatment options vary depending on the type, size, and location of the tumor, as well as the patient's overall health. Surgery is often the first line of treatment for nerve sheath neoplasms, and may be followed by radiation therapy or chemotherapy in some cases.

There are several types of facial nerve injuries, including:

1. Bell's palsy: This is a condition that affects the facial nerve and causes weakness or paralysis of the muscles on one side of the face. It is often temporary and resolves on its own within a few weeks.
2. Facial paralysis: This is a condition in which the facial nerve is damaged, leading to weakness or paralysis of the muscles of facial expression. It can be caused by trauma, tumors, or viral infections.
3. Ramsay Hunt syndrome: This is a rare condition that occurs when the facial nerve is affected by a virus, leading to symptoms such as facial paralysis and pain in the ear.
4. Traumatic facial nerve injury: This can occur as a result of trauma to the head or face, such as a car accident or a fall.
5. Tumor-related facial nerve injury: In some cases, tumors can grow on the facial nerve and cause damage.
6. Ischemic facial nerve injury: This occurs when there is a reduction in blood flow to the facial nerve, leading to damage to the nerve fibers.
7. Neurofibromatosis type 2: This is a rare genetic disorder that can cause tumors to grow on the facial nerve, leading to damage and weakness of the facial muscles.

Treatment for facial nerve injuries depends on the underlying cause and severity of the injury. In some cases, physical therapy may be recommended to help regain strength and control of the facial muscles. Surgery may also be necessary in some cases to repair damaged nerve fibers or remove tumors.

The symptoms of cranial nerve neoplasms depend on the location and size of the tumor, but may include:

* Headaches
* Pain in the face or head
* Numbness or weakness in the arms or legs
* Difficulty with vision, hearing, or balance
* Double vision
* Nausea and vomiting

Cranial nerve neoplasms can be diagnosed through a variety of tests, including:

* Imaging studies such as MRI or CT scans
* Biopsy, where a sample of tissue is removed for examination under a microscope
* Neurological examination to assess vision, hearing, balance, and other functions.

Treatment options for cranial nerve neoplasms depend on the location, size, and type of tumor, as well as the patient's overall health. Treatment may include:

* Surgery to remove the tumor
* Radiation therapy to kill any remaining cancer cells
* Chemotherapy to kill cancer cells
* Targeted therapy to attack specific molecules on the surface of cancer cells
* Observation, with regular monitoring and check-ups to see if the tumor is growing or changing.

It's important to note that cranial nerve neoplasms are relatively rare, and the prognosis and treatment options can vary depending on the specific type of tumor and the patient's overall health. A healthcare professional should be consulted for an accurate diagnosis and appropriate treatment plan.

Some examples of Facial Nerve Diseases include:

* Bell's Palsy: A condition that causes weakness or paralysis of the facial muscles on one side of the face, often resulting in drooping or twitching of the eyelid and facial muscles.
* Facial Spasm: A condition characterized by involuntary contractions of the facial muscles, which can cause twitching or spasms.
* Progressive Bulbar Palsy (PBP): A rare disorder that affects the brain and spinal cord, leading to weakness and wasting of the muscles in the face, tongue, and throat.
* Parry-Romberg Syndrome: A rare condition characterized by progressive atrophy of the facial muscles on one side of the face, leading to a characteristic "smile" or "grimace."
* Moebius Syndrome: A rare neurological disorder that affects the nerves responsible for controlling eye movements and facial expressions.
* Trauma to the Facial Nerve: Damage to the facial nerve can result in weakness or paralysis of the facial muscles, depending on the severity of the injury.

These are just a few examples of Facial Nerve Diseases, and there are many other conditions that can affect the facial nerve and cause similar symptoms. A comprehensive diagnosis and evaluation by a healthcare professional is necessary to determine the specific underlying condition and develop an appropriate treatment plan.

1. Neurodegenerative diseases: In conditions such as Alzheimer's disease and Parkinson's disease, there is evidence of retrograde degeneration of neurons, whereby affected neurons lose their mature characteristics and adopt more primitive features.
2. Retinal degeneration: In certain eye disorders, such as retinitis pigmentosa, there is retrograde degeneration of the retina, leading to loss of vision.
3. Cardiac disease: In some cases of heart failure, there is evidence of retrograde degeneration of the heart muscle, whereby the heart becomes less efficient and cannot pump blood effectively.
4. Cancer: Retrograde degeneration can occur in cancer, whereby tumor cells undergo a process of de-differentiation, losing their mature characteristics and adopting more primitive features.

In each of these cases, retrograde degeneration is often associated with a loss of function and can lead to severe clinical consequences. Understanding the mechanisms of retrograde degeneration is important for developing effective treatments and improving outcomes for patients with these conditions.

Some common abducens nerve diseases include:

1. Abducens paresis or palsy: This is a weakness or paralysis of the abducens nerve that can cause difficulty moving the eyeball outward or away from the nose.
2. Brown syndrome: This is a condition where the nerve is compressed or damaged, leading to difficulty moving the eye laterally.
3. Congenital abducens palsy: This is a condition present at birth that affects the development of the abducens nerve and can result in limited or absent movement of one or both eyes.
4. Trauma to the abducens nerve: This can occur due to head injuries, facial trauma, or other forms of injury that damage the nerve.
5. Tumors or cysts: Growths in the orbit or near the abducens nerve can compress or damage the nerve and cause abducens nerve diseases.
6. Inflammatory conditions: Conditions such as Graves' disease, multiple sclerosis, or sarcoidosis can inflame the nerve and cause abducens nerve diseases.
7. Stroke or cerebral vasculature disorders: These conditions can damage the nerve due to reduced blood flow or bleeding in the brain.

Symptoms of abducens nerve diseases may include double vision, difficulty moving one or both eyes, and difficulty focusing. Diagnosis is typically made through a combination of physical examination, imaging studies such as MRI or CT scans, and electrophysiological tests such as electromyography. Treatment options vary depending on the underlying cause of the disease and may include glasses or contact lenses for double vision, prism lenses to align the eyes, or surgery to correct any anatomical abnormalities. In some cases, medications such as steroids or immunosuppressants may be prescribed to reduce inflammation and promote healing.

The exact cause of neurilemmoma is not known, but it is believed to be related to genetic mutations that occur during fetal development. Some cases have been associated with neurofibromatosis type 2, a genetic disorder that affects the growth and development of nerve tissue.

Neurilemmoma typically manifests as a slow-growing mass or lump in the affected area. Symptoms can include pain, numbness, tingling, or weakness in the affected limb or organ, depending on the location of the tumor. In some cases, neurilemmoma can cause hormonal imbalances or disrupt normal nerve function.

Diagnosis of neurilemmoma usually involves a combination of physical examination, imaging studies such as MRI or CT scans, and a biopsy to confirm the presence of malignant cells. Treatment options for neurilemmoma include surgical removal of the tumor, radiation therapy, and in some cases, observation with periodic monitoring. The prognosis for patients with neurilemmoma is generally good if the tumor is removed completely, but recurrence is possible in some cases.

Damage or dysfunction of the oculomotor nerve can result in a range of symptoms, including double vision (diplopia), drooping eyelids (ptosis), difficulty moving the eyes (ophthalmoplegia), and vision loss. The specific symptoms depend on the location and extent of the damage to the nerve.

Some common causes of oculomotor nerve diseases include:

1. Trauma or injury to the head or neck
2. Tumors or cysts in the brain or skull
3. Inflammatory conditions such as multiple sclerosis or sarcoidosis
4. Vasculitis or other blood vessel disorders
5. Certain medications, such as anticonvulsants or chemotherapy drugs
6. Nutritional deficiencies, such as vitamin B12 deficiency
7. Infections, such as meningitis or encephalitis
8. Genetic disorders, such as hereditary oculopharyngeal dystrophy
9. Ischemic or hemorrhagic strokes
10. Neurodegenerative diseases, such as Parkinson's disease or amyotrophic lateral sclerosis (ALS).

The diagnosis of oculomotor nerve diseases typically involves a comprehensive eye exam, neurological evaluation, and imaging studies such as MRI or CT scans. Treatment depends on the underlying cause and may include medications, surgery, or other interventions to address the underlying condition and relieve symptoms. In some cases, surgical intervention may be necessary to repair or replace damaged portions of the nerve.

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The sciatic nerve (L4 to S3), the largest nerve of the body, immediately leaves the pelvis through the greater sciatic foramen ... The nerve was always seen close to and medial to the sciatic nerve when it left the sacral plexus inferior to the piriformis. ... The inferior gluteal nerve is superficial to the sciatic nerve. It has been described as having multiple branches with ... The nerve may also send a branch to the posterior femoral cutaneous nerve. The inferior gluteal nerve reliably emerged inferior ...
The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch ... The tibial nerve is the larger terminal branch of the sciatic nerve with root values of L4, L5, S1, S2, and S3. It lies ... Cutaneous branches - Tibial nerve also gives off a cutaneous nerve called the medial sural nerve from the middle of the ... Tibial nerve Tibial nerve Tibial nerve Krishna, Garg (2010). "Popliteal fossa (Chapter 6)". BD Chaurasia's Human Anatomy ( ...
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This nerve supplies feeling to the upper, outer thigh. Other nerves that may be affected are the sciatic (leading to a weakness ... Martin, H. D.; Shears, S. A.; Johnson, J. C.; Smathers, A. M.; Palmer, I. J. (2011). "The Endoscopic Treatment of Sciatic Nerve ... The most common nerve to be injured is the lateral cutaneous nerve of the thigh. ... and pudendal nerves. The pudendal nerves supply feeling to the reproductive organs. Persistent inflammation to the soft tissue ...
... the sciatic and posterior femoral cutaneous nerves; the internal pudendal artery and veins, and the nerves to the internal ... The greater sciatic notch is wider in women (about 74.4 degrees on average) than in men (about 50.4 degrees). Greater sciatic ... The greater sciatic notch is a notch in the ilium, one of the bones that make up the human pelvis. It lies between the ... The notch holds the piriformis, the superior gluteal vein and artery, and the superior gluteal nerve; the inferior gluteal vein ...
"Extracting morphometric information from rat sciatic nerve using optical coherence tomography". Journal of Biomedical Optics. ...
Raj, Phulchand (1975). "A new single-position supine approach to sciatic-femoral nerve block". Anesth Analg. 54 (4): 489-493. ... Raj, Phulchand (1973). "The use of the nerve stimulator with standard unsheathed needles in nerve blockage". Anesth Analg. 52 ( ... a new approach A new single-position supine approach to sciatic-femoral nerve block Physiology and pharmacokinetics of ... site of action of intravenous regiional anesthesia The use of the nerve stimulator with standard unsheathed needles in nerve ...
"Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response". Magnesium Research. 24 (2 ... Cobalamin deficiency manifestations are apparent in the abnormalities of the spinal cord, peripheral nerves, optic nerves, and ... In rats a marginal iron deficiency that does not cause anemia disrupted axon growth in the auditory nerve affecting auditory ... An optical coherence tomography (OCT) shows some nerve fiber layer loss in most patients, suggesting the vision loss and color ...
CerS3 is not detectable in the brain or the sciatic nerve. Like other ceramide synthases, CerS3 is found in the endoplasmic ...
The Intraneural Plexus of Fasciculi and Fibers in the Sciatic Nerve. Archives of Neurology and Psychiatry. October 1921. Vol. 6 ...
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"Acute endoneurial ischemia induced by epineurial endothelin in the rat sciatic nerve". Am. J. Physiol. 263 (6 Pt 2): H1806-10. ... choroid plexus and peripheral nerves. When applied directly to the brain of rats in picomolar quantities as an experimental ...
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"The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush". Mol. Cell. Neurosci. 12 (3): 93-104. ... This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript ...
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... their butchers extracted the sciatic nerve (Gid hanasheh) as required in Nikkur, marking them as distinct from Muslims who ...
It is accompanied by the sciatic nerve and the posterior femoral cutaneous nerves, and covered by the gluteus maximus. It ... It passes down on the sacral plexus of nerves and the piriformis muscle, behind the internal pudendal artery. It passes through ... The inferior gluteal artery (sciatic artery), the smaller of the two terminal branches of the anterior trunk of the internal ... the lower part of the greater sciatic foramen. It escapes from the pelvis between piriformis muscle and coccygeus muscle. It ...
In the early 1900s, dysfunction of the sacroiliac joint was a common diagnosis associated with low back and sciatic nerve pain ... However, research by Danforth and Wilson in 1925 concluded that the sacroiliac joint could not cause sciatic nerve pain because ... and the sciatic nerve had not yet been discovered. In 1934, the work of Mixter and Barr shifted all emphasis in research and ... Danforth, M; Wilson, P (1925). "THE Anatomy Of The Lumbo-Sacral Region in Relation To Sciatic Pain". J Bone Joint Surg Am (7): ...
Fakher Effects of odontobuthus doriae scorpion venom on mouse sciatic nerve. Iranian journal of pharmaceutical research v t e ( ...
The sciatic nerve, which is the longest and widest nerve in the human body, beginning in the lower back and running through the ...
... sciatic nerve damage in his back, and a ruptured appendix. Because of injuries, Iafrate missed all of the 1994-95 and 1995-96 ...
He suffered an injury to his sciatic nerve during the second quarter that ended his season, and ultimately his career. His Rams ...
... irritation of intercostal nerve roots, thoracic disk herniations, anterior cutaneous nerve entrapment, slipping rib syndrome, ... Those of the pelvic wall include: sciatic hernia, obturator hernia and perineal hernia. The support hernias include: vault ... Carnett thought that lower abdominal pain was commonly caused by the lower six thoracic nerves and wanted to be able to ... If this fibrous attachment becomes dislocated, the rib(s) may ride up and irritate the intercostal nerve(s), causing pain. ...
Similar mechanical allydonia induced by partial ligation of the sciatic nerve was also reduced by NaGly. Other arachidonic acid ... suggesting either a direct suppression of nociceptive afferents on the nerve or an indirect modulation of the afferents' ...
Scalp dysesthesia Sciatic nerve injury Scrotodynia Syringomyelia (Morvan's disease) Traumatic neuroma (amputation neuroma) ... myxoma of the nerve sheath, myxomatous perineurioma, nerve sheath myxoma) Nevus flammeus (capillary malformation, port-wine ... solitary nerve sheath tumor, sporadic neurofibroma) Spider angioma (nevus araneus, spider telangiectasia, spider nevus, ... granular cell nerve sheath tumor, granular cell schwannoma) Hamartoma Hemangiopericytoma Hemangiosarcoma Hibernoma (fetal ...
... reduces aging-associated myelin degeneration in the sciatic nerve of male rats". Mechanisms of Ageing and Development. 126 (11 ... "Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats". The European Journal of Neuroscience. ...
It leaves the pelvis through the greater sciatic foramen above the piriformis muscle. It is accompanied by the superior gluteal ... The superior gluteal nerve is a nerve that originates in the pelvis. It supplies the gluteus medius muscle, the gluteus minimus ... The superior gluteal nerve may be damaged by intramuscular injections and nephrectomy. Inferior gluteal nerve Trendelenburg's ... Nerves and Nerve Injuries, San Diego: Academic Press, pp. 619-626, doi:10.1016/b978-0-12-410390-0.00048-2, ISBN 978-0-12-410390 ...
The Achilles reflex checks if the S1 and S2 nerve roots are intact and could be indicative of sciatic nerve pathology. It is ... It is a type of stretch reflex that tests the function of the gastrocnemius muscle and the nerve that supplies it. A positive ... Lumbar herniated disk syndrome Lumbar spinal stenosis Endocrine disorders Hypothyroidism Sciatic neuropathy Lumbosacral plexus ...
... who was suffering an inflamed sciatic nerve. Casagrande was devastated, and Garzelli dedicated his win to Pantani. He was a ...
... the nerve which supplies that muscle, and the internal pudendal vessels and pudendal nerve. Lesser sciatic foramen Greater ... Below the ischial spine is a small notch, the lesser sciatic notch; it is smooth, coated in the recent state with cartilage, ... It is converted into a foramen, the lesser sciatic foramen, by the sacrotuberous and sacrospinous ligaments, and transmits the ... sciatic notch This article incorporates text in the public domain from page 235 of the 20th edition of Gray's Anatomy (1918) ...
Below the posterior inferior spine is a deep notch, the greater sciatic notch. This article incorporates text in the public ... Beneath this eminence is a notch from which the Sartorius takes origin and across which the lateral femoral cutaneous nerve ... but as it passes downward to the upper part of the greater sciatic notch, where it ends, it becomes less distinct, and is often ... ends at the upper part of the greater sciatic notch. The space between the anterior and posterior gluteal lines and the crest ...
The sciatic nerve block is done for surgeries at or below the knee. The nerve is located in the gluteus maximus muscle. The ... Local anesthetic nerve block (local anesthetic regional nerve blockade, or often simply nerve block) is a short-term nerve ... The local anesthetic bathes the nerve and numbs the area of the body that is supplied by that nerve. The goal of the nerve ... It is done above the knee on the posterior leg where the sciatic nerve starts splitting into the common peroneal and tibial ...
The sciatic nerve branches into the deep fibular nerve and the tibial nerve. The tibial nerve innervates the semitendinosus as ... From the sacral plexus, the lower motor neuron travels down the sciatic nerve. ...
... during development and after lesion of rat sciatic nerve". Journal of Neuroscience Research. 29 (2): 155-62. doi:10.1002/jnr. ... Masiakowski P, Shooter EM (Feb 1988). "Nerve growth factor induces the genes for two proteins related to a family of calcium- ...
An entire frog's hind leg is removed from the frog's body with the sciatic nerve still attached, and possibly also a portion of ... The leg is placed in a glass tube with just the nerve protruding. Connection is made to two different points on the nerve. ... That is, connections are made only to the nerve. Matteucci also advises that the nerve should be well stripped and that ... These may be made to the nerve and the foot of the frog's leg by wrapping them with metal wire or foil, but a more convenient ...
... satellite cells scala media scala tympani scala vestibuli scalp scaphoid scaphoid fossa scapula scar Schwann cell sciatic nerve ... cranial cranial autonomic ganglia cranial bone cranial nerve ganglia cranial nerve lesion cranial nerve nuclei cranial nerves ... abducens nerve abducens nucleus abducent abducent nerve abduction accessory bone accessory cuneate nucleus accessory nerve ... palatine canal greater palatine foramen greater palatine nerve greater petrosal nerve greater superficial petrosal nerve ...
Pain associated with the sciatic nerve usually originates higher along the spinal cord when nerve roots become compressed or ... The main nerve traveling down the leg is the sciatic nerve. ... The main nerve traveling down the leg is the sciatic nerve. ... Pain associated with the sciatic nerve usually originates higher along the spinal cord when nerve roots become compressed or ...
Femoral nerve block (FNB) leads to residual posterior knee pain; thus, currently sciatic nerve block (SNB) and LIA are two ... However, the efficacy and safety of LIA compared with combined femoral and sciatic nerve block still remain controversial. Here ... Comparison between local infiltration analgesia with combined femoral and sciatic nerve block for pain management after total ... Comparison between local infiltration analgesia with combined femoral and sciatic nerve block for pain management after total ...
Yellow circle, sciatic nerve; yellow line, anterior approach to the sciatic nerve; black line, needle path for the posterior ... Yellow dotted circle, sciatic nerve; yellow dotted line, anterior approach to the sciatic nerve; red dotted circle, vascular ... Feigl G, Hillmann, R. Part III-lower extremity: 11 proximal sciatic nerve blocks. 11.2 anterior proximal sciatic nerve block ( ... The anatomic relationship of the sciatic nerve to the lesser trochanter: implications for anterior sciatic nerve block. Anesth ...
Nerve Gliding Exercises - Sciatic ...
Injury Medical Chiropractic and Functional Medicine Clinic offer manual and motorized sciatic nerve decompression to relieve ... This type of injury compresses, pinches, or irritates one or more nerve roots that form the sciatic nerve, triggering sciatica. ... Sciatic Nerve Decompression. Portrait Of Young Arab Bodybuilder Suffering Lower Back Pain At Gym, Upset Middle Eastern Male ... Sciatic Nerve Decompression. The spine consists of 23 spinal discs that are shock absorbers for the body during movement. Each ...
The sciatic nerve is the largest nerve in the body and runs from the lower part of the spine to the legs. Sciatica, which ... The sciatic nerve is the largest nerve in the body and runs from the lower part of the spine to the legs. Sciatica, which ... How do sciatic nerve injuries manifest? April 4, 2023. April 4, 2023. admin 0 Comments ... Pain increases with movement, there is a loss of sensation and strength in the leg and foot in the area where the sciatic nerve ...
3 Grafting of the sciatic nerve; and 4 Grafting of the sciatic nerve associated with the EP. The EP was based on aerobic ... The experimental model that this aerobic treadmill exercises protocol did not modify nerve regeneration after sciatic nerve ... Use of aerobic treadmill exercises on nerve regeneration after sciatic nerve injury in spontaneously hypertensive rats ... Use of aerobic treadmill exercises on nerve regeneration after sciatic nerve injury in spo ...
It took me quite some time to get the point why I have to get my heads-down in a slump position for the sciatic nerve exercise ... Neural mobility SLUMP for Sciatic Nerve Stretch. Sit down on a chair or a stool. Put your hands together behind your back, ... I also learned another exercise to stretch my femoral nerve which is more on the side of my leg. Anyway, my notes of these two ... Prone knee bend glide for Fermoral Nerve Stretch. Lie on your side with your your bottom knee bent in front of you to protect ...
An inflammation of the sciatic nerve is sciatica. ... Sciatic nerve is a large nerve that runs from the lower spine ... 5 Causes of Sciatic Nerve Pain. HomeUncategorized5 Causes of Sciatic Nerve Pain ... The sciatic nerve is a large nerve that runs from the lower, or lumbar, spine down the back of each leg. An inflammation of the ... The physicians at Atlanta Brain and Spine Care are experts in the diagnosis and treatment of sciatic nerve pain. Contact us to ...
As a sciatic nerve treatment technique, CBT gives you some natural, conservative techniques to dealing with pain. In addition, ... Several people struggling from sciatic nerve soreness, in particular if their suffering is ongoing and long lasting for a very ... Even prior to prescribing impressive treatment for sciatic nerve solutions, physicians normally urge their clients to attain ... long time, develop symptoms of depression on top of their sciatic irritation. It is very clear that some kinds of melancholy, ...
The sciatic nerve is the largest nerve in the human body. It originates from the lumbosacral plexus (L4-S3). This nerve is ... We aim to report a rare anatomical variation of the sciatic nerve found during total hip arthroplasty in which the nerve passed ... Suprapiriformis exit of the sciatic nerve: a case report. By Managing Editor on April 1, 2019 ... and the later approach to this joint is quite frequent and care with the sciatic nerve is essential to avoid iatrogenic injury ...
The longest nerve in our bodies is the sciatic nerve, which is located at the back of the legs, and stretched from the buttocks ... Try This Simple And Effective Method And Say Goodbye To Sciatic Nerve Pain. Prev Article Next Article ... If this nerve is inflamed or irritated, it caused severe and intense pain, which starts from below the knee, above the ribs, ...
Effects of Resveratrol on Acute Sciatic Nerve Injury in a Rat Model ... during the management of acute nerve injury in a rat model. ...
The sciatic nerve is the largest nerve found inside the human body. It ultimately helps connect the nerves in the legs and feet ... causing a health issue that is best known as sciatica or sciatic nerve pain. Sciatica, or best referred to as sciatic nerve ... and transcutaneous electrical nerve stimulation, otherwise known as a TENS unit. If a persons sciatic nerve pain, or sciatica ... Sciatic nerve pain, or sciatica, is characterized by pain and discomfort, tingling sensations, and numbness as well as other ...
Nerve Blocks Reduce Opioid Prescriptions. *Ultrasound-Guided PIVs. *Higher Outpatient Satisfaction Scores with POCUS ...
56, 57] Sinha recently compared selective tibial nerve block to sciatic nerve block performed at the popliteal fossa. [58] The ... At the level of the popliteal fossa, the sciatic nerve divides into the tibial and common peroneal nerves. The advantage of a ... Value of single-injection or continuous sciatic nerve block in addition to a continuous femoral nerve block in patients ... The sciatic nerve can be blocked from a variety of approaches, including transgluteal (e.g., the classic Labat technique), ...
The Groin Support Wrap provides relief to injuries resulting from damaged, torn, or pulled groin muscles. Secondary strap targets sciatica pain. Relieves pain and promotes healing for a pulled groin, adductor muscle pain, and other groin strain symptoms through compression for home pulled groin treatment.
Symptoms Of Sciatica Are Caused By Damage To The Sciatic Nerve Or Sciatic Nerve Roots ... Comments to: Symptoms Of Sciatica Are Caused By Damage To The Sciatic Nerve Or Sciatic Nerve Roots ... Physical therapy can help strengthen the muscles in the lower back and legs, which can alleviate pressure on the sciatic nerve ... Treatment for Sciatica depends on the underlying cause of the nerve compression. In most cases, conservative treatment options ...
The character of contusive changes has been determined in the skin and sciatic nerve after lesion of soft tissues of the ... Changes in the skin and sciatic nerve after soft-tissue damage to the extremity by a high-speed small-caliber bullet]. / ... histological and histochemical techniques certain contusive changes are stated in the skin and sciatic nerve at various ... Izmeneniia v kozhe i sedalishchnom nerve posle povrezhdeniia miagkikh tkanei konechnosti vysokoskorostnoi malokalibernoi pulei. ...
... of your sciatic nerve roots, which in turn sends pain and other symptoms along your long sciatic nerve. ... When you use ice therapy for sciatica pain, apply the icepack to your lower back and rear pelvis-where the sciatic nerve roots ... Video: What Is Your Sciatic Nerve and Why Does It Hurt So Much? ... Motor and sensory nerve conduction are affected differently by ... Increasing your tolerance to pain and slowing down the speed at which your nerves send pain signals to the brain 1 Herrera E, ...
Surgery under effective peripheral nerve blocks is relatively safer. ... Safety and efficacy of anterior and posterior approaches of sciatic nerve block in high risk diabetic foot surgeries in a ... Safety and efficacy of anterior and posterior approaches of sciatic nerve block in high risk diabetic foot surgeries in a ... Aims and Objectives: To test the clinical efficacy of Sciatic Nerve Block (SNB) in elderly diabetic patients undergoing lower ...
These characteristic signs and symptoms may be from sciatic nerve compression by a contracted piriformis muscle as the nerve ... Sciatic nerve entrapment treated with section of the piriformis muscle. Acta Orthop Scand. 1981 Feb. 52(1):73-5. ... If there is enough sciatic nerve compression to cause axon loss, the abnormalities should be in the muscles distal to the ... and flexion of the thigh compress the sciatic nerve; however, this result has not been reproduced by other clinicians. Making a ...
Sciatic nerve; Seminal vesicles; Skeletal muscle; Spinal cord (cervical, thoracic and lumbar cord); Spleen; Sternum with marrow ... Eyes with optic nerve; Esophagus; Extraorbital lacrimal glands; Epididymides (modified Davidsons solution); Femur with knee ...
Sciatic nerve. Colon Seminal vesicles (with coagulating glands and fluids). Duodenum Epididymides ♦ Skin (hind limb). Eyes * ...
A novel imaging-compatible sciatic nerve schwannoma model. Journal of Neuroscience Methods. 2011:195(1)75-77. ... The first involves the development of novel therapeutic strategies for the treatment of Schwann-cell derived nerve sheath ... to investigate nociceptive processing that occurs in the context of nociceptive sensitization associated with peripheral nerve ...
Postinjection sciatic nerve palsies in infants and children. J Pediatr 1961;58:195-204. *Shaw FE Jr, Guess HA, Roets JM, et al ... or adults because of the potential risk of injury to the sciatic nerve (5). In addition, injection into the buttock has been ... to minimize the possibility of involvement with the sciatic nerve (7).. For all intramuscular injections, the needle should be ...
  • Either type can compress the sciatic nerve when they occur in the lumbar spine. (atlantabrainandspine.com)
  • According to many healthcare professionals and researchers alike, several varieties of health issues, including a spinal misalignment, also known as a subluxation, or a herniated disc, as well as various other health issues that affect any region of the human body near the sciatic nerve, can cause inflammation that will eventually compress the sciatic nerve, causing a health issue that is best known as sciatica or sciatic nerve pain. (healthvoice360.com)
  • This type of injury compresses, pinches, or irritates one or more nerve roots that form the sciatic nerve, triggering sciatica. (dralexjimenez.com)
  • Compression of this nerve (also known as the S1 nerve) is called sciatica. (dizih.com)
  • Sciatica starts as pain in the lower back, radiates to the hip, travels along the nerve from the groin to the back of the leg and then to the foot. (dizih.com)
  • Sciatica is studied in three different groups and can be viewed as an injury resulting from compression of the lumbar region, compression of the sciatic nerve in the hip muscles, and trauma to the knee or back of the foot. (dizih.com)
  • Sciatica may be the result of an injury or trauma to the sciatic nerve. (atlantabrainandspine.com)
  • Many patients will visit a healthcare professional after experiencing low back pain and a variety of other symptoms where they will then find out through a proper diagnosis that they have sciatica, or sciatic nerve pain, due to another health issue, such as a spinal misalignment or a herniated disc. (healthvoice360.com)
  • If a person's sciatic nerve pain, or sciatica, is caused by excess weight or obesity, the doctor of chiropractic can also recommend diet and lifestyle modifications to help promote weight loss and overall well-being. (healthvoice360.com)
  • Sciatica, or best referred to as sciatic nerve pain, is a collection of various symptoms instead of one variety of health issues. (healthvoice360.com)
  • Sciatic nerve pain, or sciatica, is characterized by pain and discomfort, tingling sensations, and numbness as well as other common symptoms. (healthvoice360.com)
  • The video above discusses the relief that patient Edgar M. Reyes experienced after visiting Dr. Alex Jimenez, a chiropractor in El Paso , TX, to ultimately help treat his sciatica or sciatic nerve pain, among other musculoskeletal and nervous system problems. (healthvoice360.com)
  • Treatment for Sciatica depends on the underlying cause of the nerve compression. (thewion.com)
  • When you use ice therapy for sciatica pain, apply the icepack to your lower back and rear pelvis-where the sciatic nerve roots are located. (spine-health.com)
  • Sciatica is pain that results from the irritation or compression of the sciatic nerve. (medicalnewstoday.com)
  • Pain associated with the sciatic nerve usually originates higher along the spinal cord when nerve roots become compressed or damaged from narrowing of the vertebral column or from a slipped disk. (medlineplus.gov)
  • This narrowing compresses the adjacent nerves or the spinal cord itself. (atlantabrainandspine.com)
  • The results were evaluated by the sciatic functional index (SFI), morphometric and morphologic analysis of nerve distal to the lesion, and the number of spinal cord motor neurons , positive to the marker Fluoro- Gold (FG), captured retrogradely through neurorraphy. (bvsalud.org)
  • The major compound identified in the brain, spinal cord, sciatic nerve, kidney and plasma was EPN. (cdc.gov)
  • A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. (bvsalud.org)
  • Bone spurs can be a problem if they develop in the openings for nerve roots. (atlantabrainandspine.com)
  • The lower back problem typically pinches or irritates one (or more) of your sciatic nerve roots, which in turn sends pain and other symptoms along your long sciatic nerve. (spine-health.com)
  • Sometimes, a herniated disk presses on the nerve roots that make up the sciatic nerve in the lower back and legs. (medicalnewstoday.com)
  • Because branches of the sciatic nerve extend from the lumbar spine through the buttocks and down the leg, pain, burning sensations or dull aching can present along the nerve's pathway if the nerve gets compressed or irritated. (dralexjimenez.com)
  • Like numbness, paresthesia sensations happen when a nerve is compressed or irritated. (dralexjimenez.com)
  • The experimental model that this aerobic treadmill exercises protocol did not modify nerve regeneration after sciatic nerve injury and repair with nerve graft . (bvsalud.org)
  • Motor and sensory nerve conduction are affected differently by ice pack, ice massage, and cold water immersion. (spine-health.com)
  • One important feature of botulinum toxin in pain treatment is that the neurotoxin is thought to act only on motor nerve endings while sparing sensory nerve fibers from its effects. (medscape.com)
  • An adapted chronic constriction injury of the sciatic nerve produces sensory, affective, and cognitive impairments: A peripheral mononeuropathy model for the study of comorbid neuropsychiatric disorders associated with neuropathic pain in rats. (bvsalud.org)
  • It is pain caused by compression, irritation, or inflammation of the sciatic nerve. (dralexjimenez.com)
  • Several people struggling from sciatic nerve soreness, in particular if their suffering is ongoing and long lasting for a very long time, develop symptoms of depression on top of their sciatic irritation. (goldamycin.com)
  • Peripheral nerve block (PNB) and local infiltration analgesia (LIA) are two major methods for postoperative analgesia. (iasp-pain.org)
  • These methods can be categorized into neuraxial local analgesics and opioids, peripheral nerve blocks, and wound infiltration. (medscape.com)
  • Surgery under effective peripheral nerve blocks is relatively safer. (anesthesiologypaper.com)
  • Clinical indications include the following: 1) suspected mass involving a peripheral nerve, 2) entrapment syndrome, 3) traumatic nerve injury, 4) post-treatment evaluation, and 5) symptoms unexplained by clinical examination ( 1 ). (ajnr.org)
  • This feature, as pointed out by Chappell et al in their article in this issue of the AJNR, must now be evaluated more cautiously because normal peripheral nerves can exhibit increased signal intensity, mimicking disease, depending on the orientation of the nerve relative to the main magnetic field B o of the MR system-"the magic angle" effect. (ajnr.org)
  • The similar fit for peripheral nerve and tendon data strengthens the argument for a magic angle effect and implicates collagen as the structural component responsible for the effect. (ajnr.org)
  • Depth of the target structure and general anatomy around the nerve often make definite identification challenging in a short axis view. (asra.com)
  • Figure 1: Cadaver cross-section image showing the relevant anatomy for anterior sciatic nerve block. (asra.com)
  • Giuffre BA, Jeanmonod R. Anatomy, Sciatic Nerve. (dralexjimenez.com)
  • An inflammation of the sciatic nerve may cause sharp pain that shoots down the leg and sometimes into the foot. (atlantabrainandspine.com)
  • Trauma suffered in a vehicle accident, from a contact sport, or from a fall can cause damage and inflammation to the nerve. (atlantabrainandspine.com)
  • It ultimately helps connect the nerves in the legs and feet to the nerves of the rest of the body through the central nervous system, also known as the CNS. (healthvoice360.com)
  • Radiofrequency therapy permanently disables the nerve conduction fibers in the painful area. (dizih.com)
  • The effect of cryotherapy on nerve conduction velocity, pain threshold and pain tolerance. (spine-health.com)
  • Cold therapy reduces pain by decreasing the conduction of nerves of the skin. (spine-health.com)
  • Focal or diffuse enlargement, a markedly nonuniform fascicular pattern, and loss of surrounding fat planes, as well as postcontrast enhancement of a nerve, are features that have been associated with neuropathy in the clinical settings noted above. (ajnr.org)
  • 2001 and 31 December 2003 to identify and radial nerves presents as acute periph- potential cases of TIN, using multiple diag- eral neuropathy with flaccid paralysis of nostic terms such as traumatic injection, the injected limb within 24 hours after in- traumatic neuritis, injection injury, etc. (who.int)
  • Emilio Dirlikov] Guillain-Barré Syndrome, or GBS, is a rare disease in which the person's own immune system damages the nerve cells, causing muscle weakness and sometimes even paralysis. (cdc.gov)
  • It can press on nearby nerves, causing pain. (atlantabrainandspine.com)
  • Icing this area, rather than your thigh or calf where the pain may be more, will help control and numb the pain at its origin and also calm the nearby nerves. (spine-health.com)
  • The sciatic nerve is a large nerve that runs from the lower, or lumbar, spine down the back of each leg. (atlantabrainandspine.com)
  • When a disc in the lumbar spine herniates, the result may be sciatic pain. (atlantabrainandspine.com)
  • When stenosis occurs in the lumbar spine, the sciatic nerves may become compressed and inflamed. (atlantabrainandspine.com)
  • Nervio que se origina en la médula espinal lumbar y sacra (L4 a S3) y proporciona inervación motora y sensitiva a las extremidades inferiores. (bvsalud.org)
  • The compression impedes blood circulation and nerve energy transmission. (dralexjimenez.com)
  • Compression or stretching of the sciatic nerve root in the lower back can cause leg pain. (dizih.com)
  • rather, they have been attributed to secondary effects that may be the result of muscle paralysis, improved blood flow, the release of nerve fibers under compression by abnormally contracting muscle, and, perhaps more importantly, the effects of the toxin on nociceptive neurons. (medscape.com)
  • He received femoral, obturator, and anterior sciatic blocks, and the surgery was completed successfully without any need for sedation. (asra.com)
  • So, promptly seeking care is crucial, as starting appropriate treatment can slow down and stop the progression of symptoms, limiting the damage to the nerve cells. (cdc.gov)
  • Although evidence from 40 patients demonstrated that the lateral approach might have a more rapid onset in blocking the posterior femoral cutaneous nerve, [ 4] the actual clinical significance remains debatable. (asra.com)
  • Comparison between local infiltration analgesia with combined femoral and sciatic nerve block for pain management after total knee arthroplasty. (iasp-pain.org)
  • Injury Medical Chiropractic and Functional Medicine Clinic offer manual and motorized sciatic nerve decompression to stretch/realign the spine, release the compressed nerves, and relieve pain. (dralexjimenez.com)
  • Pain increases with movement, there is a loss of sensation and strength in the leg and foot in the area where the sciatic nerve passes. (dizih.com)
  • The following are some of the most common causes of sciatic nerve pain. (atlantabrainandspine.com)
  • The physicians at Atlanta Brain and Spine Care are experts in the diagnosis and treatment of sciatic nerve pain. (atlantabrainandspine.com)
  • As a sciatic nerve treatment technique, CBT gives you some natural, conservative techniques to dealing with pain. (goldamycin.com)
  • If this nerve is inflamed or irritated , it caused severe and intense pain, which starts from below the knee, above the ribs, and the back. (newzmagazine.com)
  • Increasing your tolerance to pain and slowing down the speed at which your nerves send pain signals to the brain 1 Herrera E, Sandoval MC, Camargo DM, Salvini TF. (spine-health.com)
  • Being in certain positions, such as leaning forward when coughing, can put even more pressure on the nerves and cause lower back pain. (medicalnewstoday.com)
  • In combination with a femoral nerve block, a patient could receive full blockade of the lower extremity without the need for repositioning. (asra.com)
  • I also learned another exercise to stretch my femoral nerve which is more on the side of my leg. (sandylien.com)
  • Sciatic nerve transection and epineural repair was performed in male rats. (nih.gov)
  • Eight male rats underwent right sciatic nerve repair using 9-0 Nylon suture. (nih.gov)
  • When walking or moving the legs, the nerves transmit information to the brain, stimulating the muscles to react in specific ways. (dralexjimenez.com)
  • This includes looking for evidence of infection in different body tissues, particularly in these cases, the nerves and the brain. (cdc.gov)
  • How do sciatic nerve injuries manifest? (dizih.com)
  • Anatomical knowledge of these variants directly implies a better surgical technique, thus, the understanding the numerous dispositions of the sciatic nerve prevents iatrogenic injuries. (actasanatomica.com)
  • Morphologic and MR signal intensity characteristics of individual nerves or nerve plexuses are assessed visually in determining whether a nerve is normal or likely to have pathologic changes. (ajnr.org)
  • To test the clinical efficacy of Sciatic Nerve Block (SNB) in elderly diabetic patients undergoing lower limb surgeries without interfering with cardiovascular stability. (anesthesiologypaper.com)
  • Clinical outcomes after nerve injury and repair remain suboptimal. (nih.gov)
  • Since ultrasound became the predominant method of nerve localization in the early 2000s, we developed a technique to reliably visualize and block the sciatic nerve from an anterior approach. (asra.com)
  • The anterior approach to sciatic nerve blockade was first described by Beck in 1963. (asra.com)
  • However, even following the introduction of nerve stimulation in the 1970s, the anterior sciatic nerve block remained the providence of enthusiastic specialists. (asra.com)
  • The anterior sciatic block is well suited for continuous blockade because the thick muscle mantle provides good catheter stabilization without interfering with the patient walking on crutches. (asra.com)
  • Another study showed that the anterior approach to sciatic nerve block is performed as easily and successfully as the posterior subgluteal approach under ultrasound guidance. (asra.com)
  • The main reason the block is not a frontline block of the sciatic nerve is because of the nerve's depth with an anterior approach. (asra.com)
  • Aim: This study evaluated the therapeutic efficacy of resveratrol (RVT), a naturally occurring polyphenol, during the management of acute nerve injury in a rat model. (yyu.edu.tr)
  • This nerve is subject to numerous anatomical variations, especially its relationship with the piriformis muscle. (actasanatomica.com)
  • There were gross variations in collagen fiber organization in the repaired nerves compared with the controls. (nih.gov)
  • It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE. (bvsalud.org)
  • Users familiar with this nerve block, however, more often than not will use the technique on a regular basis because of its relatively easy landmarking, clear local anesthetic spread pattern under ultrasound guidance, and advantage in anchoring the perineural catheter. (asra.com)
  • We propose turning the ultrasound transducer to 90 degrees so that the sciatic nerve is imaged in a long axis view. (asra.com)
  • Chiropractors can also use several other treatment options together with the spinal adjustments to give patients the relief they deserve, including ice/cold therapy, ultrasound, and transcutaneous electrical nerve stimulation, otherwise known as a TENS unit. (healthvoice360.com)
  • The mean T2 for the median nerve reported by Chappell et al, though, is longer than the value for tendons, and as the magic angle is approached, the isointense or mildly hyperintense nerve becomes visibly brighter as a result of the increase in signal intensity. (ajnr.org)
  • The most important landmarks for identifying the sciatic nerve are the shaft and lesser trochanter of the femur, the adductor muscles on the ventral aspect of the sciatic nerve, and the gluteus maximus on the dorsal aspect of the nerve. (asra.com)
  • Physical therapy can help strengthen the muscles in the lower back and legs, which can alleviate pressure on the sciatic nerve. (thewion.com)
  • The first involves the development of novel therapeutic strategies for the treatment of Schwann-cell derived nerve sheath tumors. (massgeneral.org)
  • All blocks were performed with the use of a nerve stimulator, with 20 ml of local anesthetic mixture (10 ml 2% lignocaine, 9 ml of 0.5% bupivacaine and 1ml of sodium bicarbonate). (anesthesiologypaper.com)
  • Various postoperative protocols have been proposed to improve outcomes and accelerate nerve regeneration . (bvsalud.org)
  • As a person ages, their spinal column starts to narrow, and this can put more pressure on the spinal nerves. (medicalnewstoday.com)
  • The sciatic nerve is the largest nerve in the body and runs from the lower part of the spine to the legs. (dizih.com)
  • Even prior to prescribing impressive treatment for sciatic nerve solutions, physicians normally urge their clients to attain some psychological and emotional regulate over their ache. (goldamycin.com)
  • Most commonly, nerve localization by needle occurs anywhere from 7-15 cm, typically around 10 cm deep on an average patient. (asra.com)
  • The longest nerve in our bodies is the sciatic nerve, which is located at the back of the legs, and stretched from the buttocks, down the length of the legs, to the feet. (newzmagazine.com)
  • Depending on how far distally the probe is placed, the biceps femoris replaces the gluteus maximus as the muscle overlying the sciatic nerve and thus is the deepest structure on imaging. (asra.com)
  • We aim to report a rare anatomical variation of the sciatic nerve found during total hip arthroplasty in which the nerve passed above the piriformis muscle. (actasanatomica.com)
  • BoNT-A causes degrees of flaccid (rather than rigid or tetanic) paralysis by blocking acetylcholine, required for muscle contraction, from release at the nerve terminal. (medscape.com)
  • Secondary imaging characteristics such as muscle denervation changes are used to aid in identification of the affected nerve(s). (ajnr.org)
  • The main nerve traveling down the leg is the sciatic nerve. (medlineplus.gov)
  • The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. (bvsalud.org)
  • Changes in the skin and sciatic nerve after soft-tissue damage to the extremity by a high-speed small-caliber bullet]. (bvsalud.org)
  • The character of contusive changes has been determined in the skin and sciatic nerve after lesion of soft tissues of the extremity with a high-speed small-bore bullet. (bvsalud.org)
  • In the investigation performed on test- animals by means of neuromorphological, histological and histochemical techniques certain contusive changes are stated in the skin and sciatic nerve at various distances from the edge of the entrance and axis of the wound canal. (bvsalud.org)