A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
A family of scavenger receptors that mediate the influx of LIPIDS into MACROPHAGES and are involved in FOAM CELL formation.
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
A group of structurally related scavenger receptors expressed predominately by ENDOTHELIAL CELLS. They-contain repeats of EPIDERMAL GROWTH FACTOR-like cysteine-rich motifs in their extracellular domains.
Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
A family of scavenger receptors with broad polyanionic ligand binding properties that are expressed in embryonic insect MACROPHAGES.
A class of oxidized LDL receptors that contain LECTIN-like extracellular domains.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Lipid-laden macrophages originating from monocytes or from smooth muscle cells.
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A group of cell-surface receptors for oxidatively modified LOW-DENSITY LIPOPROTEINS. The group includes certain SCAVENGER RECEPTORS that contribute to the pathogenesis of ATHEROSCLEROSIS by uptake of oxidized LDL.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Established cell cultures that have the potential to propagate indefinitely.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.
A class of scavenger receptors that are specific for oxidized LOW-DENSITY LIPOPROTEINS and apoptotic cells. They are expressed almost exclusively in INTRACELLULAR MEMBRANES of MACROPHAGES.
A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE characterized by accumulation of cholesteryl ester in various tissues.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
Cell surface proteins that bind albumin with high affinity and trigger intracellular changes influencing the behavior of cells.
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Apparatus for removing exhaled or leaked anesthetic gases or other volatile agents, thus reducing the exposure of operating room personnel to such agents, as well as preventing the buildup of potentially explosive mixtures in operating rooms or laboratories.
Compounds used extensively as acetylation, oxidation and dehydrating agents and in the modification of proteins and enzymes.
A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.
Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The main trunk of the systemic arteries.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Brown MS, Goldstein JL (1985). "Scavenger cell receptor shared". Nature. 316 (6030): 680-1. doi:10.1038/316680a0. PMID 4033768 ... receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial ... Lehrman MA, Goldstein JL, Russell DW, Brown MS (Mar 1987). "Duplication of seven exons in LDL receptor gene caused by Alu-Alu ... Anderson RG, Brown MS, Goldstein JL (Mar 1977). "Role of the coated endocytic vesicle in the uptake of receptor-bound low ...
Diversity of ACAMPs requires many receptor families for their recognition. These include scavenger receptors (e.g. CD36, CD68, ... The externalized phospholipids can be oxidized and recognized by scavenger receptors of the phagocytes. Similarly, adhesion ... interacts with calreticulin which is a known C1q receptor), or complement receptors (CR3 and CR4). There is a variety of ... receptor for advanced glycation end products (RAGE), The phosphatidylserine receptor (PSR), previously thought to mediate the ...
... is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern ... "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of ... The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO is responsible for ligand ... Other members of the class A scavenger receptors tend to have alpha helical coiled coil domains, but MARCO does not. The C- ...
"Scavenger receptor B2 is a cellular receptor for enterovirus 71". Nature Medicine. 15 (7): 798-801. doi:10.1038/nm.1992. PMID ... "Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors". ... "Entrez Gene: SCARB2 scavenger receptor class B, member 2". "Protein sequence of human SCARB2 (Uniprot ID: Q14108)". Cardiac ... Mulcahy JV, Riddell DR, Owen JS (Feb 2004). "Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux ...
Connelly MA, Williams DL (June 2004). "Scavenger receptor BI: a scavenger receptor with a mission to transport high density ... Duncan KG, Bailey KR, Kane JP, Schwartz DM (April 2002). "Human retinal pigment epithelial cells express scavenger receptors BI ... SR-BI functions as a receptor for high-density lipoprotein. Scavenger receptor class B, type I (SR-BI) is an integral membrane ... Valacchi G, Sticozzi C, Lim Y, Pecorelli A (July 2011). "Scavenger receptor class B type I: a multifunctional receptor". Annals ...
These might include a 30kDa surface receptor, or macrophage scavenger receptors. The 30kDa surface receptor binds specifically ... Macrophage scavenger receptors bind to a variety of macromolecules, including polyribonucleotides and are thus candidates for ... as binding specificities of scavenger receptors vary across species. Additionally, species such as ruminants may be insensitive ... Receptor-mediated DNA uptake could be facilitated by the presence of polyguanylate sequences. Gene gun delivery systems, ...
The SR-AI/II scavenger receptor is found inside Kupffer cells. This receptor is involved in recognising and binding the lipid A ... The second hit is characterized by an activation of the Toll-like receptor 4 (TLR4) and CD14, receptors on the Kupffer cell ... identified a receptor present in Kupffer cells, the complement receptor of the immunoglobulin family (CRIg). Mice without CRIg ... March 2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915-27 ...
The most important receptors in this case are scavenger receptors, mainly SRECI and LOX-1. CD91 scavenger receptor has been ... Stimulation of some scavenger receptors can even result in immunosuppression, this is the case for SRA. LOX-1 and SRECI when ... Heat-shock proteins can signal also through scavenger receptors, which can either associate with TLRs, or activate pro- ... SRECI is now considered to by the common heat-shock protein receptor because it binds hsp60, hsp70, hsp90, hsp110, gp96 and ...
Recruited macrophages are characterized by higher expression of scavenger receptors (i.e. CD36 and macrophage scavenger ... receptor 1 (MSR1)) and lipid-handling genes (i.e. adipose differentiation-related protein (Adfp), fatty acid-binding protein 4 ...
These receptors include the G protein-coupled chemoattractant receptor FPR2 (formyl peptide receptor 2), believed to mediate ... Cai L, de Beer MC, de Beer FC, van der Westhuyzen DR (Jan 2005). "Serum amyloid A is a ligand for scavenger receptor class B ... Moreover, the Toll-like receptors TLR2 and TLR4 mediate SAA1-induced cytokine gene expression. The P2X7 purinergic receptor is ... This effect is believed to be mediated through FPR2, a G protein-coupled chemoattractant receptor. The same receptor also ...
Non-opsonic receptors include lectin-type receptors, Dectin receptor, or scavenger receptors. Some phagocytic pathways require ... Macrophages initiate phagocytosis by mannose receptors, scavenger receptors, Fcγ receptors and complement receptors 1, 3 and 4 ... The ingestion mediated by the mannose receptor is distinct in molecular mechanisms from Fcγ receptor or complement receptor ... Fcγ receptors recognise IgG coated targets. The main recognised part is the Fc fragment. The molecule of the receptor contain ...
Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also ... 1992). "Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells ... Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic ... "Entrez Gene: MSR1 macrophage scavenger receptor 1". Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori ...
... "scavenger" receptors. The net result is the shunting of LDL particles to these scavenger receptors. Scavenger receptors ... lead to competition at the ApoB100 receptor (i.e. LDL receptor) of peripheral cells. Since such competition will prolong the ... What is also clear is that the ApoB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body ... Such modifications may lessen the particles' ability to be cleared by the classic LDL receptor and/or increase their ability to ...
"Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI". Blood. 111 (4): 1962 ... Basis for the Recognition of Oxidized Phospholipids in Oxidized Low Density Lipoproteins by Class B Scavenger Receptors CD36 ... of the Binding Site for Specific Oxidized Phospholipids and Oxidized Low Density Lipoprotein of Scavenger Receptor CD36". ...
... and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors". Biochem. Biophys. Res. Commun. 290 ... Veldscholte J, Berrevoets CA, Brinkmann AO, Grootegoed JA, Mulder E (1992). "Anti-androgens and the mutated androgen receptor ...
Coombs PJ, Graham SA, Drickamer K, Taylor ME (June 2005). "Selective binding of the scavenger receptor C-type lectin to Lewisx ... recombinant human glycan-binding receptors as analytical tools". Eur. J. Cell Biol. 89 (1): 87-94. doi:10.1016/j.ejcb.2009.11. ... This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate ... "Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells ...
Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early ... 2003). "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products". J. Biol. Chem. 278 (15): 12613-7. doi: ... Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis- ... plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor ...
Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and ... "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products". The Journal of Biological Chemistry. 278 (15): ... Adachi H, Tsujimoto M (September 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis- ... The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram- ...
They can include Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), mannose receptor (MR), ... June 2017). "Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma ... Fc receptors, and DNA sensors (e.g., STING). Epithelial cells also host pathogens, like Salmonella enterica. These ... dendritic cell-specific intracellular adhesion molecule 3 (ICAM3)-grabbing nonintegrin (DC-SIGN), complement receptors, ...
G protein coupled receptor 132, also termed G2A) in Chinese hamster ovary cells made to express these receptors; they are, ... a scavenger receptor for oxidized low density lipoproteins, native lipoproteins, oxidized phospholipids, and long-chain fatty ... TRPV1 is the transient receptor potential cation channel subfamily V member 1 receptor (also termed capsaicin receptor or ... 13(S)-HODE stimulates the proliferation of human MCF-7 estrogen receptor positive and MBA-MD-231 estrogen receptor negative ...
"Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin". ... Zhao, Yutong; Natarajan, Viswanathan (January 2013). "Lysophosphatidic acid (LPA) and its Receptors: Role in Airway ... Lee, William M.; Galbraith, Robert M. (1992-05-14). "The Extracellular Actin-Scavenger System and Actin Toxicity". New England ... a disorder of the extracellular actin scavenger system, in patients with multiple sclerosis". BMC Neurology. 10 (1): 107. doi: ...
One of the specific receptors responsible for this processes is a scavenger protein, specifically the LDL Receptor-Related ... Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G (January 2000). "Role of tissue plasminogen activator receptor ... type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor". ... tPA can be absorbed by the liver and cleared from the body through receptors present therein. ...
Husemann, J.; Loike, J.D.; Anankov, R.; Febbraio, M.; Silverstein, S.C. (Nov 2002). "Scavenger receptors in neurobiology and ... "Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol". ... coupled chemoattractant receptors signal qualitatively different functions in human neutrophils". J Leukoc Biol. 71 (5): 798- ...
31] Scavenger cell receptor shared. Nature. 1985 Aug 22-28; 316 (6030) :680-1. ... 12] LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment. Cell. ... 9] A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human ... 17] Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell. 1983 Mar; 32 (3) :663-7 ...
... a scavenger receptor for oxidized low density lipoproteins, native lipoproteins, oxidized phospholipids, and long-chain fatty ... Stimulation of peroxisome proliferator-activated receptors[edit]. 13-HODE, 13-oxoODE, and 13-EE-HODE (along with their 9-HODE ... TRPV1 is the transient receptor potential cation channel subfamily V member 1 receptor (also termed capsaicin receptor or ... 13(S)-HODE stimulates the proliferation of human MCF-7 estrogen receptor positive and MBA-MD-231 estrogen receptor negative ...
Innate immune system: Pattern recognition receptors. Membrane-bound_PRRs. *Toll-like receptor ... Toll-like receptor. *NOD-like receptor. *RIG-I-like receptor. *Scavenger receptor ... Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a ... ppp RNA pattern recognition by the innate immune receptor RIG-I". Nat. Struct. Mol. Biol. 17 (7): 781-7. doi:10.1038/nsmb.1863 ...
Phagocytic scavengers, such as macrophages, have specialized receptors that recognize PS and carry out their disposal job in an ... Fas (a.k.a. Apo-1 or CD95), is another receptor of extrinsic apoptotic signals in the cell membrane, and belongs to the TNF ... The receptors in immature B and T cell membranes are not tailored precisely to coincide with "known" antigen. Rather, they are ... The cell membrane has two specialized receptors for TNF: TNF-R1 and TNF-R2. The binding of TNF to TNF-R1 has been shown to fire ...
ADP on the other hand binds to purinergic receptors on platelet surface. Since the thrombocytic purinergic receptor P2Y12 is ... "Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria". Cell. 171 (6): 1368-1382.e23. doi:10.1016/j.cell. ... It is triggered when collagen from the subendothelium binds with its receptors (GPVI receptor and integrin α2β1) on the ... These receptors trigger intraplatelet signaling, which converts GPIIb/IIIa receptors to their active form to initiate ...
Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily ... The macrophage scavenger receptor CD163.. Fabriek BO1, Dijkstra CD, van den Berg TK. ...
Binding and Uptake of Ligands by Scavenger Receptors Binding and Uptake of Ligands by Scavenger ReceptorsScavenger receptors ... Scavenging by Class A Receptors Scavenging by Class A ReceptorsClass A scavenger receptors contain an intracellular domain, a ... Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII, mRNA. NCBI Reference Sequence: NM_002445.3 ... See the reference protein sequence for macrophage scavenger receptor types I and II isoform type 2 (NP_002436.1). ...
Scavenger receptors in endocrinology are inactive membrane receptors which bind certain hormones such as IGF-1 and do not ...
... regulation of human macrophage scavenger receptor CD163 is Smad3dependent ... Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors by Lehn K. Weaver, Patricia A. Pioli ... TGF- regulation of human macrophage scavenger receptor CD163 is Smad3dependent (2004) by P A Pioli, K E Goonan, K Wardwell, P M ... Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage by Esther B. Bächli ...
Rabbit polyclonal Scavenger Receptor BI + BII antibody validated for WB, IP, BL, ICC/IF and tested in Human and Mouse. ... Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR ... All lanes : Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution. Lane 1 : wild-type mice. Lane 2 : SR-BI ... Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution + 80 µg of total mouse liver lysates. Predicted band ...
These receptors are classified according to their sequences, although in each class they are further classified based in the ... of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though ... Keywords: Scavenger receptor; Oxidized LDL particle; Atherosclerosis; Signal transduction Scavenger receptor; Oxidized LDL ... Scavenger receptors (SRs) are a superfamily of membrane-bound receptors that were initially thought to bind and internalize ...
Receptors & Other Ligands. *Scintillation Counting & Accessories*Scintillation Cocktails*Environmentally Safe. *Traditional. * ... MACROPHAGE SCAVENGER RECEPTOR (MSR-A:CD204). MONOCLONAL ANTIBODY. Anti-Human. Clone: SRA-E5. Isotype: mouse IgG1. Applications: ...
LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor ... Van Oosten M, Van de Bilt E, Van Berkel TJC, Kuiper J. New scavenger receptor-like receptors for the binding of ... Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of ... Rigotti A, Acton SL, Krieger M. The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J Biol ...
Type I and type II macrophage scavenger receptors (SR-A I/II) recognize a variety of polyanions including bacterial cell-wall ... indicating that SR-A I/II function as a receptor for L. monocytogenes. Electron microscopy revealed that most L. monocytogenes ... Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice Am J Pathol. 2001 Jan;158(1):179 ... Type I and type II macrophage scavenger receptors (SR-A I/II) recognize a variety of polyanions including bacterial cell-wall ...
The present study investigated the role of the macrophage scavenger receptor, a trimeric membrane glycoprotein, in myelin ... Receptors, Immunologic / immunology* * Receptors, Immunologic / metabolism * Receptors, Scavenger * Sciatic Nerve / cytology * ... The role of the mouse macrophage scavenger receptor in myelin phagocytosis Eur J Neurosci. 1997 Dec;9(12):2650-7. doi: 10.1111/ ... Different concentrations of the monoclonal rat anti-mouse scavenger receptor antibody (2F8) were applied to these systems to ...
Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including ... Macrophage scavenger receptor types I and IIAdd BLAST. 458. Amino acid modifications. Feature key. Position(s). Description ... Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including ... macrophage scavenger receptor types I and II isoform X2. Enhydra lutris kenyoni ...
... the one functionally characterized class C scavenger receptor (SR-C), shares with mammalian class A scavenger receptors (SR-As ... In contrast to the extreme specificity exhibited by most receptor-ligand systems, individual scavenger receptors have high ... Krieger, M., and J. Herz, 1994 Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors ... The class C scavenger receptors compose a four-member gene family in D. melanogaster, D. simulans, and D. yakuba (Figure 1). D ...
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386:292-296. doi: 10.1038/ ... Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. FASEB J 22:159-167. doi: 10.1096/fj.07- ... Pluddemann A, Hoe JC, Makepeace K, Moxon ER, Gordon S (2009) The macrophage scavenger receptor A is host-protective in ... Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage ...
... behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP- ... R-HSA-3000471. Scavenging by Class B Receptors. Miscellaneous databases. Database of phenotypes from RNA interference screens ... Cluster: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D. 10. A1L4H1-2. G3QM46. H2QH68. UPI00083C61BB ... Cluster: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D. 123. A1L4H1-2. G3QM46. H2QH68. UPI00083C61BB ...
Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J. Immunol. 175: 8032-8041. ... Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non- ... Alternatively activated macrophages express the pattern recognition receptor scavenger receptor A (SR-A). We demonstrated ... such as mannose receptor and scavenger receptor A (SR-A) (5, 6). However, the role of SR-A in TAMs is unclear. ...
scavenger receptors, class B. *sepsis. *Received September 5, 2013.. *Accepted February 24, 2014. ... Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis. Ling Guo, Zhong Zheng, Junting Ai, ... Here, we used scavenger receptor BI (SR-BI)-null mice, which are completely deficient in inducible glucocorticoids in sepsis, ... Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis ...
What is Scavenger receptor class A member 1? Meaning of Scavenger receptor class A member 1 medical term. What does Scavenger ... Looking for online definition of Scavenger receptor class A member 1 in the Medical Dictionary? Scavenger receptor class A ... A gene on chromosome 8p22 that encodes the class-A macrophage scavenger receptors, which include three different types (1, 2 ... Scavenger receptor class A member 1 , definition of Scavenger receptor class A member 1 by Medical dictionary https://medical- ...
Receptors, Immunologic. * Receptors, Lipoprotein. * Receptors, Scavenger. * Scavenger Receptors, Class A. * Scavenger Receptors ... Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. 1996 Aug 22; 382(6593):716-9. ...
... indicating CD16 can cross-block MDALDL binding to other scavenger receptors. Anti-CD16 mAb inhibited immune complex binding to ... Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E ... Recent studies showed loss of CD36 or scavenger receptor-AI/II (SR-A) does not ameliorate atherosclerosis in a hyperlipidemic ... Collectively, our findings suggest scavenger receptor activity of CD16 may, in part, contribute to the progression of ...
1994) Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related ... They strongly suggest that class A scavenger receptors are the principal receptors responsible for adhesion of macrophages to ... Therefore, to distinguish integrin receptor-mediated adhesion from scavenger receptor- mediated adhesion, we plated macrophages ... CD36, a scavenger receptor known to bind oxLDL and to signal H2O2 secretion in macrophages ((42)), is first expressed on day 2 ...
Expression of scavenger receptors in the primate eye sections showed no overlap in their pattern, suggestive of non-redundant ... Results : We detected the presence of various isoforms of all three Class B scavenger receptors in the primate eye. Relative ... In this study, we undertook a systematic approach to study the presence and function of all three Class B scavenger receptor ... In addition, the interaction of Class B scavenger receptors with carotenoids is dependent on the type and concentration of the ...
Cell surface expression of mutant SR-BI receptors. COS-7 cells expressing wild-type or mutant SR-BI receptors were incubated ... from HDL to cells is mediated by scavenger receptor class B type I (SR-BI) [13], an 82-kDa glycosylated cell surface receptor [ ... EXTRACELLULAR HYDROPHOBIC REGIONS IN SCAVENGER RECEPTOR BI PLAY A KEY ROLE IN MEDIATING HDL-CHOLESTEROL TRANSPORT. Gabriella A ... The binding of high density lipoprotein (HDL) to scavenger receptor BI (SR-BI) is responsible for whole-body cholesterol ...
atherosclerosis, chemokines, oxidized low-density lipoprotein, interferon-{gamma), scavenger receptors. in Arteriosclerosis, ... ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR ... ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR ... ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR ...
... a clustering-responsive class B scavenger receptor, as a model for studying the processes governing receptor clustering and ... Unless you happen to be an expert on cell signaling and the organization of receptors on a cells surface, you would be hard- ...
17β-Estradiol regulates scavenger receptor class BI gene expression via protein kinase C in vascular endothelial cells. Fukata ... 14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors ...
Scavenger Receptors, Class E Substances Lipids Scavenger Receptors, Class E Isotretinoin PMID: 32160377 ... e.g. G-protein-coupled receptor binding, Allergy to pollen, Retina, Rosiglitazone, GATA1) ... and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), high-sensitivity C-reactive protein, and oxidized low- ...
Manuscript: The evolution of the scavenger receptor cysteine-rich domain of the class A scavenger receptors. Posted on July 10 ... A particularly important Scavenger Receptor is Macrophage Receptor with Collagenous Structure, or MARCO. MARCO has been shown ... A particular group of receptors called Scavenger Receptors are vital to this response. A recent study published in Immunology ... Publication-Scavenger Receptors in Host Defence , Tagged bioinformatics, macrophage, manuscript, MARCO, publication, scavenger ...
Receptors recognizing viral nucleic acids during immune response of fish. Scavenger receptors in innate immunity. This is why ... Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG- ... Molecular characterization and functional analysis of toll-like receptor 3 gene in orange-spotted grouper Epinephelus coioides ...
recently cloned scavenger receptor B1 (SR-B1) can mediate selective uptake of HDL-CE when expressed in CHO cells. The ... Scavenger Receptors Medicine & Life Sciences 48% * Cholesterol Medicine & Life Sciences 36% * Apoproteins Medicine & Life ... this receptor is responsible for selective uptake of HDL-CE and LDL-CE into steroidogenic cells and the delivery of cholesterol ... both the lipoprotein particle and a putative selective uptake receptor on the cell surface. The first finding is that ...
recently cloned scavenger receptor B1 (SR-B1) can mediate selective uptake of HDL-CE when expressed in CHO cells. The ... Scavenger Receptors Medicine & Life Sciences 48% * Cholesterol Medicine & Life Sciences 36% * Apoproteins Medicine & Life ... this receptor is responsible for selective uptake of HDL-CE and LDL-CE into steroidogenic cells and the delivery of cholesterol ... both the lipoprotein particle and a putative selective uptake receptor on the cell surface. The first finding is that ...
... scavenger receptor type B; STARD1, steroidogenic acute regulatory protein; STARD3, (steroidogenic acute regulatory protein)- ... of certain steroid hormone/nuclear receptors in response to cell-membrane activated signaling cascades activates the receptor ... The message a hormone sends is received by a hormone receptor, a protein located either inside the cell or within the cell ...
LIH383 blocks the atypical "scavenger" opioid receptor ACKR3. Blockade of ACKR3 increases the availability of opioid peptides ... that can bind to classical CNS opioid receptors, thereby increasing their "natural" mood-brightening action. The negative- ... For example, the "French" antidepressant tianeptine - a full mu and delta opioid receptor agonist - can be combined with a ... selective kappa opioid receptor antagonist. (Kappa agonists induce dysphoria.) Also, perhaps add the novel agent LIH383. ...
LIH383 blocks the atypical "scavenger" opioid receptor ACKR3. Blockade of ACKR3 increases the availability of opioid peptides ... that can bind to classical CNS opioid receptors, thereby increasing their "natural" mood-brightening action. The negative- ... For example, the "French" antidepressant tianeptine - a full mu and delta opioid receptor agonist - can be combined with a ... selective kappa opioid receptor antagonist. (Kappa agonists induce dysphoria.) Also, perhaps add the novel agent LIH383. ...
LIH383 blocks the atypical "scavenger" opioid receptor ACKR3. Blockade of ACKR3 increases the availability of opioid peptides ... that can bind to classical CNS opioid receptors, thereby increasing their "natural" mood-brightening action. The negative- ... For example, the "French" antidepressant tianeptine - a full mu and delta opioid receptor agonist - can be combined with a ... selective kappa opioid receptor antagonist. (Kappa agonists induce dysphoria.) Also, perhaps add the novel agent LIH383. ...
LIH383 blocks the atypical "scavenger" opioid receptor ACKR3. Blockade of ACKR3 increases the availability of opioid peptides ... that can bind to classical CNS opioid receptors, thereby increasing their "natural" mood-brightening action. The negative- ... For example, the "French" antidepressant tianeptine - a full mu and delta opioid receptor agonist - can be combined with a ... selective kappa opioid receptor antagonist. (Kappa agonists induce dysphoria.) Also, perhaps add the novel agent LIH383. ...
LIH383 blocks the atypical "scavenger" opioid receptor ACKR3. Blockade of ACKR3 increases the availability of opioid peptides ... that can bind to classical CNS opioid receptors, thereby increasing their "natural" mood-brightening action. The negative- ... For example, the "French" antidepressant tianeptine - a full mu and delta opioid receptor agonist - can be combined with a ... selective kappa opioid receptor antagonist. (Kappa agonists induce dysphoria.) Also, perhaps add the novel agent LIH383. ...
doi:10.1007/s11886-013-0400-4. liver X receptor/retinoid X receptor (LXR/RXR). 2003; 44: 733-741. [3] Gylling H, Hallikainen M ... This way also hepatic receptors for apoB-containing lipoproteins might participate in RCT. Epub 2014 Oct 31. SR-BI is an 82-kDa ... Cells take up cholesterol from the LDL by means of LDL receptors in the outer cell membrane. 2013;48(6):10.1007/s11745-013-3780 ... Peroxisome proliferator activated receptor) stimulates ABCA1 gene transcription Fibrates Mature HDL PL C CE Apo A-1 PL C liver ...
One of those new molecules was CD5L, a lipid scavenger receptor.. The authors, led by Vijay Kuchroo, found that CD5L expression ... Apoptosis sensing receptors protect brain from vir.... *Helminths are in cahoots with commensal microbes a... ... Finally, since most of fat Tregs were positive for surface ST2, a receptor for IL-33, their depletion in ageing mice with anti- ...
scavenger receptor activity, integrin binding activity, TNF signaling, and toll-like receptor signaling. To further confirm our ... effector features against Ab-coated tumor cells had been improved via binding of MICA on monocytes to NK cell NKG2D receptors. ... 212-2 mesylate a 50-65 kDa Fcg receptor IIIa FcgRIII) Bafetinib CD47 CR2 Cyproterone acetate Danusertib Dasatinib DES Fadrozole ...
Damaged LDL is recognised by the scavenger receptor on macrophages causing them to engulf the damaged LDL. 1980;21:103-50. In ... B and metabolism of cholesterol slideshare LDL receptors inorganic phosphate ( P i ), and the LDL Receptor focuses on ... By the scavenger Receptor on macrophages causing them to engulf the damaged LDL Long short. Plays an essential role in cell ... 3. Cholesterol Metabolism, LDL, and the LDL Receptor focuses on the cholesterol biochemistry and lipoprotein metabolism. The ...
CD146 causes macrophage activation by traveling the internalization of scavenger receptor CD36 during lipid uptake. In response ... Nicotinic (??7) Receptors *NMU Receptors *NO Synthases *Non-selective Ionotropic Glutamate *NPY Receptors ... Right here, we survey that adhesion receptor Compact disc146 controls the forming of macrophage foam cells and their retention ...
... or through direct binding to various scavenger receptors. An encounter between a B‐cell and membrane‐associated antigen ... Figure 7.31 The B‐cell receptor (BCR) immunological synapse. (a) Imaging of the BCR immunological synapse. Real‐time ... Just as TCRs form immunological synapses during contact with specific peptide-MHC, B‐cell receptors have also been found to ... Antigens can be immobilized on cell surfaces by complement or Fc receptors as immunocomplexes, ...
The DC accrual of lipids is probable connected with their preferential upregulation of the scavenger receptor A (SRA1, Compact ... Vasoactive Intestinal Peptide Receptors *VR1 Receptors Recent Posts. * P-AKT protein were reduced in BEL-7402 cells treated ... Rcan1 RGS5 SLC2A4 STMN1 T cells the receptor for the complement component C3b /C4 TOK-001 UNC-1999 manufacture Vegfa ... disc204 or MSR1) [3]. This multifunctional receptor provides been proven to bind a wide selection of negatively-charged ligands ...
2004 Although CXCL16 also functions as a scavenger receptor referred to as the scavenger receptor that binds phosphatidylserine ... 1.2 Role of CXCR6 in EAE Three chemokine receptors have been implicated in guidance of T cells into the central nervous system ... 2005 and is a chemokine receptor that is expressed in activated CD4+ T cell subsets (Loetscher et al. 1997 Matloubian et al. ... 2000 CXCR6 (also called BONZO STRL33 and TYM-STR) the CXCL16 receptor (Matloubian et al. 2000 Shimaoka et al. 2000 could be ...
The scavenger receptor Compact disc36 identifies oxLDL and mediates its uptake into cells and has Imiquimod pontent inhibitor a ... Vanillioid Receptors *Vascular Endothelial Growth Factor Receptors *Vasoactive Intestinal Peptide Receptors *Vasopressin ... as well as the membrane receptor cluster of differentiation 36 (Compact disc36), involving different vascular pathological ...
full-length human TMPRSS13 (WT-TMPRSS13); transmembrane domain; lipoprotein receptor class A domain; scavenger cysteine-rich ... Posted in Sigma Receptors After that, the MCF7 cells were then re-suspended in Annexin-V binding buffer (BD Biosciences, San ... Posted in Kisspeptin Receptor The left window shows the original recordings of ICC\DMP and the right window shows Ca2+ ... Posted in Kisspeptin Receptor As expected, we detected indicators for IRF4, IRF8, Help and BLIMP1 transcripts in LPS- ...
1Recognition via the class A scavenger receptor modulates cytokine secretion by human dendritic cells after contact with ... A,BacterialCapsules,Cells,ClassCultured,DendriticFactor-alphaHumans,Interleukins,NecrosisNeisseriaPhagocytosis,Receptors, ...
Dpp signaling in ML-DmD17-c3 cells is primarily mediated by the receptors Put and Tkv, with additional contributions from Wit ... one of the Type I BMP receptors (Thickveins - Tkv, or Saxophone - Sax) [14, 15]. The activated receptor complex recruits and ... Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem. 2006;281: ... 3a-b, respectively), the receptors tkv, sax, put and wit (Fig. 3c-f, respectively), and the intracellular transducers Mad and ...
... scavenger receptor BI (SR-BI), and the tight-junction (TJ) protein claudin 1 (CLDN1). The recent discovery of a TJ protein as a ... These data support a model where TJs provide a physical barrier for viral access to receptors expressed on lateral and ... Viral receptor expression levels increased upon polarization, and CLDN1 relocalized from the apical pole of the lateral cell ... Three host cell molecules have been reported to be important entry factors for receptors for HCV: the tetraspanin CD81, ...
Toll Like Receptor 4 (TLR4), Toll Like Receptor 6 (TLR6) and the class B scavenger receptor type II. In this study, we tested ... Previous studies have shown that different receptors of the innate immune system bind to Aβ and activate distinctive signaling ... One way by which microglia recognize Aβ is through a heterodimer of three cell-surface receptors, ...
At least three host cell molecules have been reported to be important for HCV entry: the tetraspanin CD81, scavenger receptor ... HCV pseudoparticles infect human liver derived cell lines and this suggests that liver-specific receptors contribute to ... At least three host cell molecules have been reported to be important for HCV entry: the tetraspanin CD81, scavenger receptor ... Hepatitis C virus receptor expression in normal and diseased liver tissue. Reynolds GM., Harris HJ., Jennings A., Hu K., Grove ...
Other host factors CD81, scavenger receptor B1 and tight junction proteins claudin-1 and occludin allow for clathrin-dependent ... through receptors known as Pattern Recognition Receptors (PRRs) which include Toll like receptors (TLRs) and RIG-1 like ... Upon administration of IFN- α, the type I interferon binds to IFNAR-1 and IFNAR-2 receptors on cell surfaces initiating a ... As previously discussed, HCV blocks TLR3 and RIG-1 receptors reducing type I IFN production. [5,11] Thus overwhelming host ...
  • They were first described for macrophages as alternative receptors to the LDL receptor in the uptake of (excessive) cholesterol and lipid, leading to the development of foam cells. (ahajournals.org)
  • The present study investigated the role of the macrophage scavenger receptor, a trimeric membrane glycoprotein, in myelin uptake by macrophages. (nih.gov)
  • Concentration-dependent effects on macrophage migration and myelin uptake were seen when the macrophage scavenger receptor was blocked by the antibody 2F8. (nih.gov)
  • Expression of scavenger receptors in the primate eye sections showed no overlap in their pattern, suggestive of non-redundant roles in carotenoid uptake. (arvojournals.org)
  • The carotenoid uptake efficiency by these receptors, however, was dependent on the concentration of carotenoids. (arvojournals.org)
  • It is identical to scavenger receptor SR-PSOX, which mediates uptake of oxidized low-density lipoprotein. (lu.se)
  • Our recent study has suggested that pDNA is taken up by mouse peritoneal macrophages via a specific mechanism mediated by a receptor similar to the scavenger receptor (SR). This study was designed to further characterize the pDN A uptake by macrophages in order to elucidate the mechanism. (ovid.com)
  • The binding and uptake of pDNA labeled with 32P or a fluorescent marker were studied in vitro using cultured Chinese hamster ovary (CHO) cells expressing the class A scavenger receptor (SRA) and peritoneal macrophages from SRA-knockout mice. (ovid.com)
  • The present study suggest that pDNA binding and uptake by mouse peritoneal macrophages are mediated by a specific mechanism to some defined polyanions not by scavenger receptors. (ovid.com)
  • These data suggest that based on the specific prophagocytic receptors mediating uptake of senescent RBCs, the phagocytosis-inhibitory role of CD47 may be more or less involved. (diva-portal.org)
  • Surprisingly, a comparison of BMMφ from wild-type and SR-A knockout (SR-A −/− ) mice showed that nonopsonic phagocytosis of meningococci was mediated almost exclusively via SR-A. Previous studies have demonstrated only a partial involvement of the receptor in the uptake of other bacteria, such as Escherichia coli . (asm.org)
  • Thus, we show that Mφ SR-A mediates opsonin-independent uptake of N. meningitidis independently of lipid A and that this activity is uncoupled from the Mφ secretion of proinflammatory cytokines, which provides a basis for further investigation of the role of this receptor in meningococcal disease in humans. (asm.org)
  • Macrophage-derived foam cells play a pivotal role in atherosclerotic plaque formation by expressing scavenger receptors that regulate lipid uptake. (uzh.ch)
  • Antibody-mediated blocking of Lox-1 receptor decreased the hypoxic induction of oxLDL uptake and lipid content. (uzh.ch)
  • Conclusions: Hypoxia increases lipid uptake into macrophages and differentially regulates the expression of oxLDL receptors. (uzh.ch)
  • We hypothesized that spherical HDL crosses the endothelium similar to lipid-free apoA-I and therefore investigated binding, uptake, and transport of HDL by cultured aortic ECs and the involvement of the ATP-binding cassette transporters ABCA1 and ABCG1, as well as the HDL receptor scavenger receptor (SR)-BI. (ahajournals.org)
  • Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). (neuromics.com)
  • To learn more about how the step of cholesterol uptake into the brush border membrane (BBM) of enterocytes influences overall cholesterol absorption, we measured cholesterol absorption 4 and 24 h after administration of an intragastric bolus of radioactive cholesterol in mice with scavenger receptor class B, type 1 (SR-BI) and/or cluster determinant 36 (CD36) deleted. (semanticscholar.org)
  • Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies. (semanticscholar.org)
  • Scavenger receptor class B type I (SR-BI) binds HDL and mediates selective uptake of cholesterol ester and cellular efflux of cholesterol to HDL. (biomedcentral.com)
  • The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. (semanticscholar.org)
  • Class A scavenger receptors, macrophage receptor with collagenous structure (MARCO) and scavenger receptor A (SR-A), which are expressed on macrophages, play important roles in the uptake of apoptotic cells. (biomedcentral.com)
  • Macrophage class A scavenger receptor types I and II (SR-AI and II) mediate the uptake of oxidized LDL in atherosclerotic lesions. (ox.ac.uk)
  • The recently described type III receptor (SR-AIII), which lacks amino acids encoded by exon 10 of the SR-A gene, is unable to mediate the uptake of ligands and acts as a dominant negative regulator in the trimeric SR-A molecule. (ox.ac.uk)
  • These data indicate that the macrophage scavenger receptor is involved in myelin phagocytosis by macrophages. (nih.gov)
  • Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. (genetics.org)
  • Amiel E, Acker JL, Collins RM, Berwin B (2009) Uncoupling scavenger receptor A-mediated phagocytosis of bacteria from endotoxic shock resistance. (springer.com)
  • CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages. (diva-portal.org)
  • CD47 functions as a marker of self on red blood cells (RBCs) by binding to signal regulatory protein alpha on macrophages, preventing phagocytosis of autologous RBCs by splenic red pulp macrophages, and Fcgamma receptor (FcgammaR)- or complement receptor-mediated phagocytosis by macrophages in general. (diva-portal.org)
  • Phagocytosis of Ox-RBCs was mediated by scavenger receptors (SRs) distinct from SR-A or CD36 and required serum factors. (diva-portal.org)
  • Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. (semanticscholar.org)
  • Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation. (semanticscholar.org)
  • This aim will characterize signaling mechanisms for SRA-mediated particle phagocytosis and AM modulation, including identification of co-receptors and signals for particle intemalization, and expression profiling of genetic programs triggered by SRA ligation. (grantome.com)
  • The complex process of phagocytosis involves a range of receptors, ligands, and opsonins, which are involved in the recognition and internalization of apoptotic cells. (biomedcentral.com)
  • It is proposed that autoantibodies blocking scavenger receptors may alter the phagocytosis of apoptotic cells by macrophages, and, thereby, facilitate the development of an autoimmune response. (biomedcentral.com)
  • The receptor isoforms have been implicated in both macrophage-associated physiological and pathological processes, including atherosclerosis, Alzheimer's disease and host defence. (thefreedictionary.com)
  • Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice. (sigmaaldrich.com)
  • Recent studies showed loss of CD36 or scavenger receptor-AI/II (SR-A) does not ameliorate atherosclerosis in a hyperlipidemic mouse model, suggesting receptors other than CD36 and SR-A may also contribute to atherosclerosis. (sigmaaldrich.com)
  • Collectively, our findings suggest scavenger receptor activity of CD16 may, in part, contribute to the progression of atherosclerosis. (sigmaaldrich.com)
  • Atherosclerosis is an inflammatory disease that is characterised by the involvement of chemokines that are important for the recruitment of leukocytes and scavenger receptors that mediate foam cell formation. (diva-portal.org)
  • Several cytokines are involved in the regulation of chemokines and scavenger receptors in atherosclerosis. (diva-portal.org)
  • 1979) and such receptors have been shown to participate in pathological processes such as atherosclerosis. (reactome.org)
  • These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. (nih.gov)
  • Macrophage scavenger receptors (MSR) promote atherosclerotic lesion formation, and modulation of MSR activity has been shown to influence atherosclerosis. (ox.ac.uk)
  • Scavenger receptors (SRs) are a 'superfamily' of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. (mdpi.com)
  • Scavenger receptor class B type I (SR‑BI), a well‑documented high‑density lipoprotein receptor, has been implicated in the development and progression of human cancer. (spandidos-publications.com)
  • Scavenger receptor class B type I (SR-BI) is a well-documented high-density lipoprotein (HDL) receptor, which is most abundantly expressed in liver and the steroidogenic tissues, including the ovaries, testes and adrenal glands ( 3 ). (spandidos-publications.com)
  • The binding of high density lipoprotein (HDL) to scavenger receptor BI (SR-BI) is responsible for whole-body cholesterol disposal via reverse cholesterol transport. (pubmedcentralcanada.ca)
  • Scavenger receptor class B type I (SR-BI) is an essential receptor for hepatitis C virus (HCV) and a cell surface high-density-lipoprotein (HDL) receptor. (asm.org)
  • Methods and results: Using RT-qPCR, flow cytometry and immunoblotting, we found that mRNA and protein expression levels of the scavenger receptor A (SRA) and the cluster of differentiation 36 (CD36)were upregulated by oxidized low-density lipoprotein (oxLDL), but decreased following exposure of macrophages to hypoxia. (uzh.ch)
  • Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles (Goldstein et al. (reactome.org)
  • In human plasma, HCV particles have been reported to be complexed with lipoproteins, suggesting an indirect interaction of the virus with SR-BI and other lipoprotein receptors. (core.ac.uk)
  • Fucoidan, a known ligand of class A macrophage scavenger receptors (MSR-A), significantly reduced macrophage adhesion to surfaces coated with oxLDL or acLDL. (rupress.org)
  • In addition, the interaction of Class B scavenger receptors with carotenoids is dependent on the type and concentration of the ligand. (arvojournals.org)
  • We conclude that the hydrophobicity of N-terminal extracellular regions of SR-BI is critical for cholesterol transport, possibly by mediating receptor-ligand and/or receptor-membrane interactions. (pubmedcentralcanada.ca)
  • Receptor/ligand blocking assays confirmed that class A scavenger receptors (SR-A) facilitated dsRNA binding and subsequent gene expression. (ovid.com)
  • Most importantly, SR-BI mutants defective for sE2 binding, although retaining wild-type activity for receptor oligomerization and binding to the physiological ligand HDL, were impaired in their ability to fully restore HCVcc infectivity when transduced into an SR-BI-knocked-down Huh-7.5 cell line. (asm.org)
  • Interestingly, we also show that lipopolysaccharide (LPS) was not the ligand for the receptor on these organisms. (asm.org)
  • 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. (reactome.org)
  • As apo A-I is a ligand for scavenger receptor class B type I (SR-BI) we have characterized the expression of this receptor in murine gallbladder.Reverse transcription-polymerase chain reaction (RT-PCR), immunoblotting and immunohistochemistry were used to study SR-BI expression in murine gallbladders. (gu.se)
  • Purified recombinant scavenger receptor cysteine-rich (SRCR) polypeptide (ligand-binding domain of MARCO) and recombinant SR-A were used as antigens. (biomedcentral.com)
  • Recently, two human transmembrane proteins, P-selectin glycoprotein ligand-1 (PSGL-1) and scavenger receptor class B, member 2 (SCARB2), were identified as functional receptors for EV71 and CVA16. (frontiersin.org)
  • Interestingly, sCD16 inhibited MDALDL binding to macrophage cell line, as well as soluble forms of recombinant mouse CD36, SR-A, and LOX-1, indicating CD16 can cross-block MDALDL binding to other scavenger receptors. (sigmaaldrich.com)
  • Moreover, in addition to LOX-1, several scavenger receptors, such as Scarf1, Cd36 and Stabilin-1, facilitated the efficient internalisation of Ecrg4(71-132) into cells. (omictools.com)
  • Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice. (ox.ac.uk)
  • CXCL16 is a chemokine and scavenger receptor and found in macrophages in human atherosclerotic lesions. (diva-portal.org)
  • We hypothesized that class A scavenger receptor (SR-A), a key modulator of inflammation, may steer macrophage polarization, which in turn influences cardiomyocytes necrosis after MI. (springer.com)
  • Abstract: The hemoglobin-haptoglobin (Hb-Hp) scavenger receptor CD163 is a monocyte/macro-phage-restricted surface antigen, whose expression is strongly up-regulated by glucocorticoids. (psu.edu)
  • Abstract: The hemoglobin (Hb) scavenger re-ceptor, CD163, is a cell-surface glycoprotein that is expressed exclusively on monocytes and macrophages. (psu.edu)
  • These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). (uniprot.org)
  • The peptide and its cargo form stable, negatively charged nanoparticles that are taken up by cells largely through scavenger receptor type A mediated endocytosis. (diva-portal.org)
  • As the intracellular fate of particles taken up by (receptor mediated) endocytosis is entrapment in endosomes this thesis also presents a new peptide for ON delivery that has endosomolytic properties. (diva-portal.org)
  • Additionally this new peptide (PepFect 15) is also taken up via receptor-mediated endocytosis by the SCARAs. (diva-portal.org)
  • It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. (mybiosource.com)
  • The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). (nih.gov)
  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicin. (nih.gov)
  • A gene on chromosome 8p22 that encodes the class-A macrophage scavenger receptors, which include three different types (1, 2 and 3) generated by alternative splicing of MSR1. (thefreedictionary.com)
  • 1) Nitric oxide (NO) production in response to Mycobacterium bovis BCG or bacterial lipopolysaccharide (LPS) by scavenger receptor (ScR) gene knockout (ScR-/-) mice and their parent strain of wild type (ScR+/+) mice were examined. (nii.ac.jp)
  • The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. (mybiosource.com)
  • The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in several processes proposed to be relevant to prostate carcino-genesis 5-10 . (elsevier.com)
  • The PS-binding receptor TIM-4 (encoded by the Timd4 gene) contributes to efficient cell-to-cell spread by L. monocytogenes in macrophages in vitro and growth of these bacteria is impaired in Timd4 −/− mice. (nature.com)
  • Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. (nih.gov)
  • The critical nature of the extracellular domain of SR-BI in CE transfer has been demonstrated through the use of chimeric receptors [ 29 - 31 ] and insertion of epitope tags into various regions of the extracellular domain of SR-BI [ 32 ]. (pubmedcentralcanada.ca)
  • Micellar lipid composition affects micelle interaction with class B scavenger receptor extracellular loops. (semanticscholar.org)
  • The aim of this study was to examine the mechanisms of scavenger receptors at recognition of extracellular ONs and their complexes with CPPs. (ut.ee)
  • We have generated a secreted macrophage scavenger receptor (sMSR) that consists of the bovine growth hormone signal sequence and the human MSR A I extracellular domains. (ox.ac.uk)
  • There are two types of MSR-A. Type I receptors contain a cysteine-rich domain at their COOH (exofacial) terminus, whereas type II receptors do not. (rupress.org)
  • CD163 has been described as a fusion receptor for PRRSV, with the scavenger receptor cysteine-rich domain 5 (SRCR5) region having been shown to be the interaction site for the virus. (asm.org)
  • However, NO production by MP and NO levels in plasma of ScR-/- mice were clearly different from those of ScR+/+ mice, and seemed to depend on the regulation of background genes of the mice rather than the genes of scavenger receptor. (nii.ac.jp)
  • New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. (mdpi.com)
  • and class C contains only the Drosophila SR-C. Class D, E, and F receptors have only recently been identified, and none of these show any structural similarity with class A, B, or C receptors (see Figure ⇓ for classes and structures). (ahajournals.org)
  • I find here that nonsynonymous divergence in three class C scavenger receptors ( Sr-C 's) between Drosophila melanogaster and D . simulans and between each of these species and D . yakuba is approximately four times the typical genome average. (genetics.org)
  • Several studies have pointed to the role of Class B scavenger receptors as carotenoid transporters. (arvojournals.org)
  • In this study, we undertook a systematic approach to study the presence and function of all three Class B scavenger receptor proteins in the primate eye. (arvojournals.org)
  • We detected the presence of various isoforms of all three Class B scavenger receptors in the primate eye. (arvojournals.org)
  • Our data suggest that all three Class B scavenger receptors can function as carotenoid transporters in the vertebrate eye. (arvojournals.org)
  • CD5 and CD6 are two highly homologous class I SRs mainly expressed on all T cells and the B1a cell subset, and involved in the fine tuning of activation and differentiation signals delivered by the antigen-specific receptors (TCR and BCR, respectively), to which they physically associate. (classicistranieri.com)
  • Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. (semanticscholar.org)
  • Pharmacological inhibition and siRNA knockdown of the class A scavenger receptors (SCARAs) demonstrate that these receptors are the main pathway by which CPP:ON complexes are taken up. (diva-portal.org)
  • Problem: The health effects of inhaled environmental exposures are determined in large part by the 'first responded cell of the lung, the alveolar macrophage (AM). The important initial contact of AMs with inhaled agents is through members of the 'scavenger1 receptor class A family (SRA), especially MARCO and SRAI/II. (grantome.com)
  • Expression of scavenger receptor class B type I in gallbladder columnar epithelium. (gu.se)
  • The purpose of this study was to investigate the prevalence of anti-class A scavenger receptor antibodies in patients with various autoimmune diseases, in particular SLE, and the functional implication of those autoantibodies in the phagocytic clearance of apoptotic cells by macrophages. (biomedcentral.com)
  • Our results indicated that autoantibodies to class A scavenger receptors might contribute to the breakdown of self-tolerance by impairing the clearance of apoptotic debris and play a role in the pathogenesis of autoimmune disease, especially in SLE. (biomedcentral.com)
  • Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation. (ox.ac.uk)
  • ITX5061 is a scavenger receptor class B type I antagonist that blocks HCV entry and infection in vitro. (ox.ac.uk)
  • Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. (nih.gov)
  • The name scavenger receptor was well chosen, because they recognize a broad array of ligands. (ahajournals.org)
  • We tentatively identified several potential ligands for the SR-A receptor in tumor cell-macrophage cocultures by mass spectrometry. (jimmunol.org)
  • Scavenger Receptors (SRs) from the host's innate immune system are known to bind multiple ligands to promote the removal of non-self or altered-self targets. (classicistranieri.com)
  • Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a common property, such as polyanionic charges. (reactome.org)
  • Scavenger receptors in endocrinology are inactive membrane receptors which bind certain hormones such as IGF-1 and do not transmit an intracellular response. (wikipedia.org)
  • Scavenger receptors are broadly defined by their ability to bind modified low-density lipoproteins and other polyanions, including proteins, lipids, carbohydrates, and nucleic acids ( 7 ). (jimmunol.org)
  • These professional antigen-presenting cells are able to discriminate unmodified self from non-self thanks to pattern recognition receptors such as the Toll like Receptors (TLR) and Scavenger Receptors (SR). SR were originally identified by their ability to bind and internalize modified lipoproteins and microorganisms but also particles and TLR agonists. (inserm.fr)
  • Efferocytosis is mediated, in part, by receptors that bind to exofacial phosphatidylserine (PS) on cells or cellular debris after loss of plasma membrane asymmetry. (nature.com)
  • Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor. (ox.ac.uk)
  • Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb. (elifesciences.org)
  • Alternatively activated macrophages express the pattern recognition receptor scavenger receptor A (SR-A). We demonstrated previously that coculture of macrophages with tumor cells upregulates macrophage SR-A expression. (jimmunol.org)
  • The listerial phagocytic activities of MSR-A+/+ macrophages treated with an anti-SR-A I/II antibody (2F8) and MSR-A-/- macrophages were significantly impaired compared with untreated MSR-A+/+ macrophages, indicating that SR-A I/II function as a receptor for L. monocytogenes. (nih.gov)
  • Different concentrations of the monoclonal rat anti-mouse scavenger receptor antibody (2F8) were applied to these systems to selectively block the macrophage scavenger receptor. (nih.gov)
  • 11 ] that SRA could ensure an inflammatory response of the appropriate magnitude via modulation of the activities of pro-inflammatory receptors and production of chemokines. (biomedcentral.com)
  • Another study, which used P388D1 murine macrophages, showed differences in the expression levels of SR-AI and SR-AII, 5 with the type I receptor expression by P338D1 cells substantially less than that of the type II receptor. (ahajournals.org)
  • Publications] 中野昌康(他3名): 'The role of scavenger receptor on nitric oxide production by the murine peritoneal macrophages in response to Mycobacterium bovis BCG or bacterial lipopolysaccharlde' 1996年度 日米医学協力計画報告 (nii.ac.jp)
  • Publications] Nakano, M., kirikae, T., kirikae, F., and Saito, S.: 'The role of scavenger receptor on nitric oxide production by the murine peritoneal macrophages in response to Mycobacterium bovis BCG or bacterial lipopolysaccharide' Reports of US-Japan Medical Cooperation Projects. (nii.ac.jp)
  • glucan receptors participate in the recognition of yeasts by murine macrophages. (grantome.com)
  • Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. (abcam.com)
  • In contrast, lectin-like oxLDL receptor (Lox-1) mRNA and protein levels were upregulated under hypoxic conditions. (uzh.ch)
  • Identifying the specific receptors involved, and understanding the exact mechanisms of how CPPs and their complexes with ONs reveal their activity inside cells are highly essential in order to harness such complexes for medical purposes. (ut.ee)
  • In in vitro infection experiments using the prototype HEV-A strains, PSGL-1 and SCARB2 could be responsible for the specific receptors for EV71 and CVA16. (frontiersin.org)
  • The macrophages present in neoplastic tissues (TAMs) mainly display an M2-like phenotype with expression of classes of innate pattern recognition receptors, such as mannose receptor and scavenger receptor A (SR-A) ( 5 , 6 ). (jimmunol.org)
  • The roles of two pattern recognition molecules, the Mφ scavenger receptor (SR-A) and Toll-like receptor 4 (TLR-4), have been investigated using bone marrow culture-derived Mφ (BMMφ). (asm.org)
  • Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up? (semanticscholar.org)
  • The role of these pattern-recognition receptors in lung defense against inhaled oxidants and how they function for clearance and signaling are important but unanswered questions. (grantome.com)
  • The current view is that HCV entry into target cells occurs after attachment to specific cellular receptors via its surface glycoproteins E1 and E2 ( 27 ). (asm.org)
  • Scavenger receptor A (SRA), also known as CD204, is a trimeric type II transmembrane glycoprotein expressed as two functional splice variants, SRA-I and SRA-II. (biomedcentral.com)
  • Immunostaining was carried out in sections of macaque eye using the above mentioned antibodies to determine the expression pattern of scavenger receptors in the primate eye. (arvojournals.org)
  • The macrophage scavenger receptor CD163. (nih.gov)
  • These findings imply that SR-A I/II plays a crucial role in host defense against listerial infection not only by functioning as a receptor but also by mediating listericidal mechanisms through the regulation of LLO-dependent listerial escape from the macrophages. (nih.gov)
  • However,the role of hypoxia in scavenger receptor regulation remains incompletely understood. (uzh.ch)
  • The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. (nih.gov)
  • Implication of scavenger receptors in the interactions between diesel exhaust particles and immature or mature dendritic cells. (inserm.fr)
  • We draw upon our pilot studies and the available literature to formulate our central hypothesis: AMscavenger receptors protect the lung directly by clearance of pathogenic particles and indirectly by removal of the pro-inflammatory oxidized lipids generated within alveolar lining fluid. (grantome.com)
  • SCAVENGER receptors (SRs) compose a protein family defined by gross structural similarities and participation in cellular internalization of foreign compounds. (genetics.org)
  • Induction of internalization of such complexes into cells through simple electrostatic interactions with cell membrane is unlikely, and probably it occurs in a receptor-dependent manner. (ut.ee)
  • Scavenger receptor BI (SR-BI) and CD81 are important entry factors for HCV internalization into target cells. (core.ac.uk)
  • We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. (elifesciences.org)
  • The majority of these M cell receptors have been identified on gastrointestinal M cells, while receptor expression by airway microfold cells is less well understood. (elifesciences.org)
  • CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. (lu.se)
  • Therefore, we generated a cDNA library from Jurkat T cells and used it for expression cloning to identify a receptor on lymphocytes that specifically binds to EV71. (frontiersin.org)
  • See the reference protein sequence for macrophage scavenger receptor types I and II isoform type 2 (NP_002436.1). (nih.gov)
  • This activation was dependent on MyD88, an adaptor protein that recruits signalling proteins to Toll-like receptors (TLRs), with the consequent induction of various immune responses. (omictools.com)
  • Surface plasmon resonance experiments were conducted to determine the binding affinity of carotenoids with scavenger receptor proteins. (arvojournals.org)
  • Type I and type II macrophage scavenger receptors (SR-A I/II) recognize a variety of polyanions including bacterial cell-wall products such as lipopolysaccharide, suggesting a role for SR-A I/II in immunity against bacterial infection. (nih.gov)
  • 他4名): 'The role of scavenger receptor in LPS-induced macrophage activation' Endotoxin and Sepsis(John Wiley & Sons,Inc.). (印刷中). (nii.ac.jp)
  • This review summarizes our current understanding of the EV71/CVA16 receptors and their role in HEV-A infection. (frontiersin.org)
  • Therefore, this chemokine/scavenger receptor could serve as a molecular link between lipid metabolism and immune activity in the atherosclerotic lesion. (lu.se)
  • However, the involvement of both receptors in the in vitro and in vivo infections of clinical isolates of HEV-A has not been clarified yet. (frontiersin.org)
  • MBS044938 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sCD163/Soluble Haemoglobin Scavenger Receptor, ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Soluble receptors are effective in inhibiting receptor-mediated functions in various diseases. (ox.ac.uk)
  • Increased expression of SR-BI and SR-BII in the Huh-7.5 hepatoma cell line enhanced HCV strain J6/JFH and JFH infectivity, suggesting that endogenous levels of these receptors limit infection. (core.ac.uk)
  • It was also observed that lipopolysaccharides derived from Salmonella minnesota Re 5g5 (Re mutant) was far more effective in inhibiting the binding of acetylated LDL (AcLDL) by the type II receptor than by the type I receptor, indicating different binding affinities for the 2 forms. (ahajournals.org)
  • Functional and possible physical association of scavenger receptor with cytoplasmic tyrosine kinase Lyn in monocytic THP-1-derived macrophages. (semanticscholar.org)
  • were identified as functional receptors for EV71 and CVA16 ( Patel and Bergelson, 2009 ). (frontiersin.org)