Satellite Cells, Skeletal Muscle: Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.PAX7 Transcription Factor: A paired box transcription factor that is involved in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM and SKELETAL MUSCLE.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Muscle Development: Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.Regeneration: The physiological renewal, repair, or replacement of tissue.Muscle Fibers, Skeletal: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.MyoD Protein: A myogenic regulatory factor that controls myogenesis. Though it is not clear how its function differs from the other myogenic regulatory factors, MyoD appears to be related to fusion and terminal differentiation of the muscle cell.Muscles: Contractile tissue that produces movement in animals.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Satellite Cells, Perineuronal: The non-neuronal cells that surround the neuronal cell bodies of the GANGLIA. They are distinguished from the perineuronal satellite oligodendrocytes (OLIGODENDROGLIA) found in the central nervous system.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.DNA, Satellite: Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Myoblasts: Embryonic (precursor) cells of the myogenic lineage that develop from the MESODERM. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes (MYOCYTES, SKELETAL; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE).Myogenic Regulatory Factor 5: A SKELETAL MUSCLE-specific transcription factor that contains a basic HELIX-LOOP-HELIX MOTIF. It plays an essential role in MUSCLE DEVELOPMENT.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Myogenin: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.RNA, Satellite: Small, linear single-stranded RNA molecules functionally acting as molecular parasites of certain RNA plant viruses. Satellite RNAs exhibit four characteristic traits: (1) they require helper viruses to replicate; (2) they are unnecessary for the replication of helper viruses; (3) they are encapsidated in the coat protein of the helper virus; (4) they have no extensive sequence homology to the helper virus. Thus they differ from SATELLITE VIRUSES which encode their own coat protein, and from the genomic RNA; (=RNA, VIRAL); of satellite viruses. (From Maramorosch, Viroids and Satellites, 1991, p143)Mice, Inbred mdx: A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Muscle Fibers, Fast-Twitch: Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified.Myoblasts, Skeletal: Precursor cells destined to differentiate into skeletal myocytes (MYOCYTES, SKELETAL).Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Muscle Fibers, Slow-Twitch: Skeletal muscle fibers characterized by their expression of the Type I MYOSIN HEAVY CHAIN isoforms which have low ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment.Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.Mitochondria, Muscle: Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.Satellite Communications: Communications using an active or passive satellite to extend the range of radio, television, or other electronic transmission by returning signals to earth from an orbiting satellite.Desmin: An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.Paired Box Transcription Factors: A family of transcription factors that control EMBRYONIC DEVELOPMENT within a variety of cell lineages. They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.Myostatin: A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.Muscle Denervation: The resection or removal of the innervation of a muscle or muscle tissue.Mice, Inbred C57BLSatellite Viruses: Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Muscle Cells: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS, SKELETAL), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Muscle Fatigue: A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Quadriceps Muscle: The quadriceps femoris. A collective name of the four-headed skeletal muscle of the thigh, comprised of the rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis.GlycogenMyofibrils: The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .Myosin Heavy Chains: The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.Cell SeparationCardiotoxins: Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Hepatocyte Growth Factor: Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
"Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment". The ... Males typically have more skeletal muscle mass than females. Androgens promote the enlargement of skeletal muscle cells and ... probably act in a coordinated manner to function by acting on several cell types in skeletal muscle tissue. One cell type ... A minor population of nonepithelial cells appear between the tubules by week 8 of human fetal development. These are Leydig ...
Mir-133 microRNA precursor family
miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls myogenic vs. brown ... "MicroRNA regulation of cell lineages in mouse and human embryonic stem cells". Cell Stem Cell. 2 (3): 219-29. doi:10.1016/j. ... "MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16". Cell Metabolism. 17 ... BMP2 controls bone cell determination by inducing miRNAs that target muscle genes but mainly by down-regulating multiple miRNAs ...
Moški spolni hormon - Wikipedija, prosta enciklopedija
"Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment". The ... januar 2006). "Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor ... complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription ...
"Satellite cell activation in human skeletal muscle after training: evidence for muscle fiber neoformation". Int J Sports Med. 9 ... Satellite cells are precursors to skeletal muscle cells, able to give rise to satellite cells or differentiated skeletal muscle ... Myosatellite cells or satellite cells are small multipotent cells with virtually no cytoplasm found in mature muscle. ... HGF testing is also used to identify active satellite cells. Activated satellite cells also begin expressing muscle-specific ...
Zammit, PS; Partridge, TA; Yablonka-Reuveni, Z (November 2006). "The skeletal muscle satellite cell: the stem cell that came in ... List of skeletal muscles of the human body. References. *^ Birbrair, Alexander; Zhang, Tan; Wang, Zhong-Min; Messi, Maria ... A skeletal muscle refers to multiple bundles (fascicles) of cells joined together called muscle fibers. The fibres and muscles ... Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle. It is a form of striated ...
Zammit, PS; Partridge, TA; Yablonka-Reuveni, Z (November 2006). "The skeletal muscle satellite cell: the stem cell that came in ... An example of this architecture would be the human deltoid muscle. In addition to the actin and myosin components that ... A skeletal muscle refers to multiple bundles of cells called muscle fibers (fascicles). The fibres and muscles are surrounded ... Skeletal Muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle. It is a form of striated ...
Actin, alpha 1
Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin ... alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene. Actin alpha 1 which is expressed in skeletal ... "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell ... 1983). "Isolation and characterization of cDNA clones for human skeletal muscle alpha actin". Nucleic Acids Res. 11 (11): 3503- ...
Zammit, PS; Partridge, TA; Yablonka-Reuveni, Z (November 2006). "The skeletal muscle satellite cell: the stem cell that came in ... An example of this architecture would be the human deltoid muscle. Types of muscle by actionEdit. See also: Anatomical terms of ... A skeletal muscle refers to multiple bundles (fascicles) of cells joined together called muscle fibers. The fibers and muscles ... Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle. It is a form of striated ...
Induced stem cells
"A Novel Approach to Collecting Satellite Cells From Adult Skeletal Muscles on the Basis of Their Stress Tolerance". Stem Cells ... human PSC-derived insulin-expressing cells resemble human fetal β cells rather than adult β cells. In contrast to adult β cells ... human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen-presenting cells". Gene ... "Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells". Cell Stem Cell. 12 (1): 31-6 ...
... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... accompanied by a smaller number and size of the muscle cells as well as lower protein content. In humans, prolonged periods of ... Muscle atrophy is defined as a decrease in the mass of the muscle; it can be a partial or complete wasting away of muscle, and ... Other syndromes or conditions which can induce skeletal muscle atrophy are liver disease, and starvation. Muscle atrophy occurs ...
List of distinct cell types in the adult human body
Intermediate skeletal muscle cell Nuclear bag cell of muscle spindle Nuclear chain cell of muscle spindle Satellite cell (stem ... Ito cell) Pancreatic stelle cell Skeletal muscle cell Red skeletal muscle cell (slow) White skeletal muscle cell (fast) ... cell) Heart muscle cells Ordinary heart muscle cell Nodal heart muscle cell Purkinje fiber cell Smooth muscle cell (various ... Hybridoma cell Mast cell Helper T cell Suppressor T cell Cytotoxic T cell Natural killer T cell B cell Natural killer cell ...
"Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise". Journal of ... help initiate the process of muscle repair and growth by activating satellite cells within the inflamed muscle. Satellite cells ... "Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise". Journal of ... "Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy". Cell Metabolism. 7 (1): 33-44 ...
Myoblasts in skeletal muscle that do not form muscle fibers dedifferentiate back into myosatellite cells. These satellite cells ... ISBN 978-1-4160-6257-8. "Muscle tissues". Scott, W; Stevens, J; Binder-Macleod, SA (2001). "Human skeletal muscle fiber type ... and smooth muscle cells, with various properties. The striated cells of cardiac and skeletal muscles are referred to as muscle ... Zammit, PS; Partridge, TA; Yablonka-Reuveni, Z (November 2006). "The skeletal muscle satellite cell: the stem cell that came in ...
... "satellite cells" that help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... Muscle Architecture and Muscle Fiber Anatomy". Skeletal Muscle: Form and Function (2nd ed.). Champaign, IL: Human Kinetics. pp ... where they fuse into elongate skeletal muscle cells. The three types of muscle (skeletal, cardiac and smooth) have significant ... and propagate contractions to other muscle cells they are in contact with. All skeletal muscle and many smooth muscle ...
Myoblasts in skeletal muscle that do not form muscle fibers dedifferentiate back into myosatellite cells. These satellite cells ... MacIntosh, Brian R.; Gardiner, Phillip F.; McComas, Alan J. (2006). Skeletal Muscle: Form and Function. Human Kinetics. ISBN ... However muscle cells cannot divide to produce new cells, and as a result we have fewer muscle cells as an adult than a newborn. ... "The skeletal muscle satellite cell: the stem cell that came in from the cold". Journal of Histochemistry and Cytochemistry. 54 ...
... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... However, the drug's long-term effect on the heart precludes its routine use in humans, and other drugs are being sought. ... which is notable for the severe muscle atrophy seen. Other syndromes or conditions which can induce skeletal muscle atrophy are ... During aging, there is a gradual decrease in the ability to maintain skeletal muscle function and mass. This condition is ...
Efferent nerve fiber
The efferent nerve fibers of motor neurons are involved in muscle control, both skeletal and smooth muscle. The cell body of ... The cell body of the motor neuron is satellite-shaped. The motor neuron is present in the grey matter of the spinal cord and ... Mader S. S. (2000): Human biology. McGraw-Hill, New York, ISBN 0-07-290584-0; ISBN 0-07-117940-2. Hall J. E., Guyton A. C. ( ... that target intrafusal muscle fibers. Beta motor neurons target both types of muscle fiber and there are two types known as ...
... "satellite cells" that help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... Muscle Architecture and Muscle Fiber Anatomy". Skeletal Muscle: Form and Function (2nd ed.). Champaign, IL: Human Kinetics. pp ... The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle. (Same ... and propagate contractions to other muscle cells they are in contact with. All skeletal muscle and many smooth muscle ...
Wnt plays a crucial role in satellite cell regulation and skeletal muscle aging and also regeneration. Wnts are known to active ... "Human PubMed Reference:". "Mouse PubMed Reference:". Davis RL, Weintraub H, Lassar AB (Dec 1987). "Expression of a single ... Motohashi, N.; Asakura, Atsushi (January 2014). "Muscle satellite cell heterogeneity and self-renewal". Frontiers in Cell and ... MyoD mRNA levels are also reported to be elevated in aging skeletal muscle. One of the main actions of MyoD is to remove cells ...
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Particular interests include the basic biology of satellite and muscle stem cells, excitation-contraction coupling, muscle ... Muscle Biology and Diseases-support PDCTC research projects in skeletal muscle biology and diseases. They focus on the ... Specific attention is paid to progenitor cells obtained from human tissue samples and their trophic and differentiation ... Laboratory of Stem Cell Biology-studies cell fate and tissue development. It examines various types of stem cells to generate ...
As one of the key cell markers of satellite cells (the stem cell pool for skeletal muscles), it plays an important role in the ... "Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5". Biology of ... "Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells". The Journal of Cell ... regulation of vertebrate skeletal myogenesis by cell-cell contact". Journal of Cell Science. 118 (Pt 11): 2355-62. doi:10.1242/ ...
... it may be induced by a combination of a gradual failure in the satellite cells which help to regenerate skeletal muscle fibers ... the drug's long-term effect on the heart precludes its routine use in humans, and other drugs are being sought. ... Muscle atrophies. Main article: Muscle atrophy. Disuse atrophy of muscles and bones, with loss of mass and strength, can ... which is notable for the severe muscle atrophy seen. Other syndromes or conditions which can induce skeletal muscle atrophy are ...
"Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle". Stem Cells. 25 (10): 2448-2459. doi:10.1634/ ... Hayflick L; Moorhead PS (December 1961). "The serial cultivation of human diploid cell strains". Exp. Cell Res. 25: 585-621. ... including muscle stem cells (MuSCs), neural stem cells (NSCs), intestinal stem cells (ISCs), and many others. Stem cell ... Muscle growth can be stimulated by growth or injury and involves the recruitment of muscle stem cells - also known as satellite ...
... myogenic precursors expressing Pax3 and/or Pax7 form satellite cells within the skeletal muscle, which contribute to postnatal ... Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. The ... To form other skeletal muscles, Pax3-expressing cells detach from the dermomyotome and migrate to more distant sites, such as ... To form skeletal muscle in central body segments, PAX3-expressing cells detach from the dermomyotome and then Pax3 expression ...
Muscle memory (strength training)
... connective tissue and muscle stem cells called satellite cells. Since in vivo imaging has confirmed that cell nuclei are added ... "The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts". PLOS ... Muscle memory is probably related to the cell nuclei residing inside the muscle fibers, as is described below. The muscle cells ... the muscle cells are one of the very few in the mammalian body that contain several cell nuclei. Such multinucleated cells are ...
"Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population". J. Cell Biol ... Derlin-3 is a protein that in humans is encoded by the DERL3 gene. Derlin-1 Derlin-2 ENSG00000099958 GRCh38: Ensembl release 89 ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10- ...
Wnt plays a crucial role in satellite cell regulation and skeletal muscle aging and also regeneration. Wnts are known to active ... "P15172 (MYOD1_HUMAN)". UniProtKB. Retrieved 17 July 2019.. *^ a b Davis RL, Weintraub H, Lassar AB (Dec 1987). "Expression of a ... muscle cell fate commitment. • cellular response to estradiol stimulus. • skeletal muscle fiber adaptation. • muscle organ ... skeletal muscle cell differentiation. • positive regulation of skeletal muscle tissue regeneration. • regulation of gene ...
The chronaxie values for human denervated skeletal muscle ranges from 9.5 to 30 ms at body temperature, representing a ratio of ... is possibly related not only to activation and proliferation of the satellite cells but also to regulation of the cell cycle. ... Muscle excitability decreased early after denervation. Chronaxie from 0.1-0.2 ms in innervated muscle changed to 0.5-1 ms ... Chronaxie is dependent on the density of voltage-gated sodium channels in the cell, which affect that cell's excitability. ...
Satellite cells are small mononuclear cells that abut the muscle fiber. Satellite cells are normally activated upon injury or ... Sarcopenia is also marked by a decrease in the circumference of distinct types of muscle fibers. Skeletal muscle has different ... and disease has shown that early environmental influences on growth and development may have long-term consequences for human ... One theory is that sarcopenia is in part caused by a failure in satellite cell activation. Extreme muscle loss is often a ...
Satellite cells in human skeletal muscle : molecular identification quantification and function
satellite cell markers, NCAM, Pax7, MyoD, myogenin, DLK1/FA1, c-Met, human skeletal muscle, immunohistochemistry, muscle growth ... When the present thesis was initiated, studies on satellite cells in human skeletal muscle relied on the neuronal cell adhesion ... 3. Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: ... Satellite cells in human skeletal muscle: molecular identification quantification and function. Lindström, Mona Umeå University ...
Assessment of satellite cell number and activity status in human skeletal muscle biopsies
... Mackey, A. L. ... aim of our study was to validate the assessment of myonuclear and satellite cell number in biopsies from human skeletal muscle ... We observed very few (up to 1.3%) active satellite cells in healthy adult skeletal muscle at rest, but they increased ... Active satellite cell, Muscle fiber, Myonucleus, NCAM, Pax7 National Category Sport and Fitness Sciences Research subject. ...
Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle...
Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle ... Skeletal muscle satellite cells (SCs) are involved in remodeling and hypertrophy processes of skeletal muscle. However, little ... In a comparative human study, we investigated the muscle fiber type-specific association between emergence of satellite cells ( ... Muscle biopsies (vastus lateralis) were analyzed for fiber type-specific SCs, myonuclei, and fiber cross-sectional area (CSA). ...
Frontiers | Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults |...
The EPOR is present in human skeletal muscle. In mouse skeletal muscle, EPO stimulation can activate the AKT serine/threonine ... In mouse skeletal muscle, EPO stimulation can activate the AKT serine/threonine kinase 1 (AKT) signalling pathway, the main ... Conclusions: Despite its ability to activate the AKT pathway in skeletal muscle, an acute EPO injection had no additive or ... 2 h after the injection, the subjects completed an acute bout of leg extension resistance exercise to stimulate skeletal muscle ...
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population | JCB
Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the ... Satellite cells can be copurified with isolated single skeletal muscle fibers. (A-D) Satellite cells are attached to the ... The skeletal muscle satellite cell: stem cell or son of stem cell? Differentiation. 68:193-204. ... Pax7+ cells are present in newt limb skeletal muscle. (A and B) Immunostaining of limb skeletal muscle identifies Pax7+ cells ...
Ultrastructural localization of concanavalin A-binding sites in satellite cells of human skeletal muscle | SpringerLink
Electron-microscopic cytochemical studies on satellite cells of normal human skeletal muscle were carried out using the ... Ultrastructural localization of concanavalin A-binding sites in satellite cells of human skeletal muscle. Cell Tissue Res. 210 ... Laguens R (1963) Satellite cells of skeletal muscle fibers in human progressive muscular dystrophy. Virchows Arch Pathol Anat ... Ultrastructural localization of concanavalin A-binding sites in satellite cells of human skeletal muscle. *Yoshihiro Wakayama1 ...
An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration | Development
2007). Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat. Cell Biol. 9, 255-267. ... 2005). Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell ... DEVELOPMENT AND STEM CELLS An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle ... DEVELOPMENT AND STEM CELLS An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle ...
'satellite cells skeletal muscle' Protocols and Video...
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans, Purification of Progenitors from Skeletal Muscle, ... and Transplantation of Muscle Satellite Cells, Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of ... Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease, Human Skeletal Muscle Biopsy Procedures Using the ... Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles, Isolation and Characterization of Satellite Cells from ...
Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory |...
We have also recently undertaken DNA methylome analysis (850,000 + CpG sites) in human skeletal muscle after acute and chronic ... and comparing these large data sets with our genome-wide DNA methylation analysis in human skeletal muscle after acute and ... this study identifies novel differentially methylated genes associated with human skeletal muscle anabolism, hypertrophy and ... Within skeletal muscle tissue, these cancer genes predominant functions were associated with matrix/actin structure and ...
Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies | Scientific...
To analyze the effect of different degrees of muscle degeneration in SCs behavior, we studied adult muscle of the dystrophic ... are the main muscle stem cells responsible for its regenerative capacity. In muscular dystrophies, however, a failure of the ... Nonetheless, the maturation of these new fibers is incomplete and do not prevent muscle degeneration. Taken together, these ... We concluded that dystrophic muscles, independently of their degeneration degree, retain their SCs pool with proliferating and ...
Protein Availability and Satellite Cell Dynamics in Skeletal Muscle | SpringerLink
It was initially proposed that satellite cell pr ... Human skeletal muscle satellite cells are activated in response ... Assessment of satellite cell number and activity status in human skeletal muscle biopsies. Muscle Nerve. 2009;40:455-65. ... A single bout of exercise activates skeletal muscle satellite cells during subsequent overnight recovery: satellite cell ... Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle ...
skeletal muscle satellite cell migration Antibodies | Invitrogen ...
Antibodies for proteins involved in skeletal muscle satellite cell migration pathways, according to their Panther/Gene Ontology ... Antibodies for proteins involved in skeletal muscle satellite cell migration pathways; according to their Panther/Gene Ontology ... Human Mouse Rat Details. Mouse Monoclonal Application. ICC IF IHC (P) IP WB ...
Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma |...
Restoration of skeletal muscle defects with adult human cells delivered on fibrin microthreads. Tissue Eng. Part A 17, 2629- ... Muscle satellite cells (MuSCs) are muscle-resident stem cells that play an indispensable role in myogenesis, and their function ... Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell 134, 37-47 (2008).. ... Satellite cell activation and apoptosis in skeletal muscle from severely burned children. J. Physiol. 594, 5223-5236 (2016).. ...
JCI - Human satellite cells have regenerative capacity and are genetically manipulable
Satellite cells are the proper stem cells of the adult skeletal muscle. Like other stem cell types, these cells are maintained ... Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol. 2007;9(3):255-267. ... compared with satellite cells, such alternative cell types have limited ability to form muscle stem cells (satellite cells) and ... Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012;23(3):469 ...
Differential Expression of Cell-Surface Antigens on Muscle Satellite Cells and Myoblasts | SpringerLink
The differentiation of mononucleate myoblast cells into postmitotic multinucleated myotubes is accompanied by the activation ... Satellite Cell Human Skeletal Muscle Cryostat Section Motor Neuron Disease Myoblast Cell These keywords were added by machine ... Walsh F.S., Moore S.E., Nayak R. (1985) Differential Expression of Cell-Surface Antigens on Muscle Satellite Cells and ... Differential Expression of Cell-Surface Antigens on Muscle Satellite Cells and Myoblasts. ...
JCI - Stem cell therapy for muscular dystrophies
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol. 2007;9(3):255-267. ... Myogenic stem and progenitor cells from skeletal muscle. Satellite cells. Skeletal muscle tissue possesses a tremendous ... Human satellite cell transplantation and regeneration from diverse skeletal muscles. Stem Cell Reports. 2015;5(3):419-434. ... Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. Nat Protoc. 2016;11(10): ...
Androgen - Wikipedia
"Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment". The ... Males typically have more skeletal muscle mass than females. Androgens promote the enlargement of skeletal muscle cells and ... probably act in a coordinated manner to function by acting on several cell types in skeletal muscle tissue. One cell type ... A minor population of nonepithelial cells appear between the tubules by week 8 of human fetal development. These are Leydig ...
Dissertations.se: SATELLITE CELLS
... about SATELLITE CELLS. Search and download thousands of Swedish university dissertations. Full text. Free. ... satellite cell markers; NCAM; Pax7; MyoD; myogenin; DLK1 FA1; c-Met; human skeletal muscle; immunohistochemistry; muscle growth ... Human Anatomy; Abstract : Skeletal muscle satellite cells located between the plasma membrane and the basal lamina of muscle ... 1. Satellite cells in human skeletal muscle molecular identification quantification and function. University dissertation from ...
Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear
Glut5 mRNA is also detected in the human brain, kidney, skeletal muscle, and adipocytes. Glut5 immunoreactivity was found as a ... Glut1 is also expressed in the satellite cells encasing spiral ganglion neurons . Absorption of fructose in the intestine ... Inner ears hair cells are receptor cells that convert mechanical stimuli into electrical signals. These cells are responsible ... in vascular smooth muscle cells," American Journal of Physiology-Cell Physiology, vol. 304, no. 6, pp. C574-C589, 2013. View at ...
SIX5 - Homeobox protein SIX5 - Homo sapiens (Human) - SIX5 gene & protein
negative regulation of skeletal muscle satellite cell proliferation Source: Ensembl. *negative regulation of transcription, DNA ... List of human entries with polymorphisms or disease mutations *Human polymorphisms and disease mutations. Index of human ... J. Muscle Res. Cell Motil. 23:255-264(2002) [PubMed] [Europe PMC] [Abstract] ... J. Muscle Res. Cell Motil. 23:255-264(2002) [PubMed] [Europe PMC] [Abstract] ...
Insulin-like growth factor-I E peptides: implications for aging skeletal muscle.
... is important in regard to muscle mass maintenance, repair and hypertrophy. This mature IGF-I comprises e ... In skeletal muscle there is good evidence to suggest that locally produced insulin-like growth factor-1 (IGF-I), rather than ... Muscle, Skeletal / physiology*. Protein Isoforms. RNA, Messenger / chemistry. Sarcopenia / physiopathology. Satellite Cells, ... In human skeletal muscle three transcripts encoding for these splice variants (IGF-IEa, IGF-IEb and IGF-IEc, also known as MGF ...
Ponsot E[au] - PubMed - NCBI
Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti- ... The biology of satellite cells and telomeres in human skeletal muscle: effects of aging and physical activity. ... Extensive inflammatory cell infiltration in human skeletal muscle in response to an ultraendurance exercise bout in experienced ... Regenerative capacity of human satellite cells: the mitotic clock in cell transplantation. ...
Articles by PER AAGAARD : Medicine & Science in Sports & Exercise
Changes in Satellite Cell and Myonuclei Number in Human Skeletal Muscle with Resistance Training: Effects of Creatine and ... Ageing Affects Cell Cycle Regulation In Human Skeletal Muscle Undergoing Atrophy And Regrowth: 903 Board #82 May 31 330 PM - ... Effects of Chronic Blood-Flow Restriction Exercise on Skeletal Muscle Size and Myogenic Satellite Cell Expression: 3703 Board # ... Correlation between contractile strength and myosin heavy chain isoform composition in human skeletal muscle. AAGAARD, PER; ...
Ionizing Radiation Potentiates High-Fat Diet-Induced Insulin Resistance and Reprograms Skeletal Muscle and Adipose Progenitor...
Assessment of satellite cell number and activity status in human skeletal muscle biopsies. Muscle Nerve 2009;40:455-465pmid: ... like cancer cells, are most susceptible (7). Progenitor cells, including skeletal muscle satellite cells, are more sensitive to ... Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells. J Clin Invest 2010;120:11-19pmid:20051632. ... Irradiation alters insulin-stimulated ERK signaling of skeletal muscle progenitor cells. Satellite cells were isolated from ...
Lifeboat Foundation News Blog: DNA - Page 7
Study based upon human skeletal muscle aging, mutagenesis, and the role of #satellite cells. "A more comprehensive ... Human aging has multiple effects on the human body. One of the effects of human aging is the reduction in skeletal muscle (SkM ... Tags: aging, biology, dna, Muscles, Mutagenesis, Myofiber, Physiological, RNA, Satellite Cells, Skeletal, Soma ... Human Skeletal Muscle Aging and Mutagenesis Posted by Nicholi Avery in categories: aging, DNA, genetics, health, life extension ...
Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans - Full Text View -...
Successful skeletal muscle regeneration depends on a functional pool of muscle stem cells, termed satellite cells (SC). SC are ... PT supplementation will promote skeletal muscle regeneration after muscle damage in elderly humans by enhanced recruitment of ... Presence of Satellite Cells [ Time Frame: Change from baseline up to 45 days ]. quantified by immunohistochemistry in muscle ... Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans. The safety and ...
Articles by Robert D. Hyldahl : Medicine & Science in Sports & Exercise
Satellite Cell Response to a Repeated Bout of Eccentric Contractions in Human Skeletal Muscle: 2386 Board #91 May 30, 9: 30 AM ... Activation of NF-kB in Pericytes of Human Skeletal Muscle Following Eccentric Exercise-Induced Damage. Hyldahl, Robert D.; Xin ... Alpha7 Beta1 Integrin mRNA and Protein Responses to Repeated Bouts of Eccentric Contractions in Human Skeletal Muscle: 1506 ... Deep Tissue Heating Increases Mitochondrial Respiratory Capacity of Human Skeletal Muscle: 1607 Board #282 June 1 9: 00 AM - 10 ...
Quantifying Nuclear DNA Mutation Rates in Stem Cells Doesn't Tell Us the Degree to which those Mutations Contribute to Aging -...
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging Satellite cells (SCs) are a heterogeneous ... researchers have investigated the number of mutations that accumulate in the muscles stem cells (satellite cells). "What is ... skeletal muscles and skin) will soon be easier to print or grow in a bioreactor than to mess with their cell therapy. Of course ... of their cells in 80 years of life. We can replace these dying cells with new healthy cells, and thus dilute the overall level ...
Molecular networks in skeletal muscle plasticity | Journal of Experimental Biology
2004). The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles. J. Physiol. 558, ... Activation of satellite cells. Satellite cells located beneath the basal lamina of muscle cells are instrumental for growth and ... Satellite cells are a heterogeneous population of cells with the majority of cells being committed, satellite myogenic cells, ... A smaller number of satellite cells (satellite stem cells) undergo asymmetric division, repopulate the satellite cell niche and ...
References Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | Abcam
References for Human, Mouse, Rat in Flow Cyt, ICC/IF, IF, IHC, IHC - Wmt, IHC-FoFr, IHC-Fr, IHC-P, WB ... Savikj M et al. Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals ... Frock RL et al. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev 20:486-500 ( ... Martin SD et al. Enhanced proliferation of human skeletal muscle precursor cells derived from elderly donors cultured in ...
Age and sex affect human muscle fibre adaptations to heavy-resistance strength training - Martel - 2006 - Experimental...
Satellite cells in human skeletal muscle; from birth to old age, AGE, 2014, 36, 2, 545. CrossRef ... The role of donor age and gender in the success of human muscle precursor cell transplantation, Journal of Tissue Engineering ... Blunted hypertrophic response in old mouse muscle is associated with a lower satellite cell density and is not alleviated by ... M. S. Brook, D. J. Wilkinson, B. E. Phillips, J. Perez-Schindler, A. Philp, K. Smith, P. J. Atherton, Skeletal muscle ...
Karolinska Institutet Discovers | Staff Portal | Karolinska Institutet
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging, Nature Communications, February 23, 2018 ... Modulation of Protein-Interaction States through the Cell Cycle, Cell, April 26, 2018 ... Stereotypic immune system development in newborn children, Cell, August 23, 2018. The seminar will be held in Erna Möllersalen ... Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma , Blood,Jun 14, 2018 ...
DifferentiationFibersMouse skeletal muscleMicePrecursorPathwaysProtein synthesisRegenerativePathwayCapacity of skeletal muscleDifferentiateSupplementationMechanismsProliferationStem cellAdult skeletal muscleRegulationPlasticityMolecularProgenitorExtracellular matrixSarcopeniaRegenerateInflammationHomeostasisMyogenic cellsPluripotentMammalian skeletal muscleExercise inducedRegenerative capacityMyofibersPhenotypeDystrophicMitochondrialFunctionalRoles in skeletal muscleRegeneration of skeletal muscleGrowthImmunohistochemistryActivationVastus lateralisCapacity of skeletalBiologyEmbryonic2018ResistanceRepairDamageCellularPopulationsBoneHealthy adultMyosin
- Sub-objective 1.A. Determine in vivo the number of skeletal muscle satellite cells undergoing division, apoptosis, and differentiation in term fetuses of mouse dams that are fed a protein-restricted (PR) or a control (C) diet ad libitum during gestation. (usda.gov)
- Sub-objective 1.B. Determine in vivo the number of skeletal muscle satellite cells undergoing division, differentiation, and apoptosis in 21-d-old mouse pups that are suckled by dams fed either a PR or a C diet ad libitum from birth. (usda.gov)
- Quantify and compare the in vitro replicative, differentiation, and fusion capacities of satellite cells isolated from muscles of 21-d-old offspring that were suckled on C or PR dams when they are cultured in vitro under identical conditions. (usda.gov)
- In vivo satellite cell responses and skeletal muscle growth will be assessed primarily by immunohistofluorescence imaging with morphometry to assess cell division, apoptosis, differentiation, and muscle mass. (usda.gov)
Mouse skeletal muscle1
- We hypothesized that a single intravenous EPO injection combined with acute resistance exercise would have a synergistic effect on skeletal muscle protein synthesis via activation of the AKT pathway. (frontiersin.org)
- 2 h after the injection, the subjects completed an acute bout of leg extension resistance exercise to stimulate skeletal muscle protein synthesis. (frontiersin.org)
- However, EPO offered no synergistic effect on vastus lateralis mixed muscle protein synthesis rate in young or older subjects. (frontiersin.org)
Capacity of skeletal muscle1
- "Our study demonstrates that neither leucine nor protein supplementation (standardized to leucine) in previously untrained, college-aged males provide added benefit in increasing whole-body skeletal muscle mass or whole-body strength," wrote lead researcher Michael Roberts. (nutraingredients.com)
- The study findings are consistent with an earlier meta-analysis , which found that protein supplementation had little muscle hypertrophic effect in athletes who had undertaken little or no previous RET. (nutraingredients.com)
- Other studies have also reported increases in satellite cell numbers in response to protein supplementation and strength training programmes of similar duration. (nutraingredients.com)
- Previous studies suggested that supplementation of lactating sows with β -hydroxy- β -methylbutyrate (HMB) could improve the performance of weaning pigs, but there were little information in the muscle fiber type transformation of the offspring and the subsequent performance in pigs from weaning through finishing in response to maternal HMB consumption. (biomedcentral.com)
- Objective 2: Determine if impaired catch-up growth upon nutritional rehabilitation is due to aberrant epigenetic mechanisms intrinsic to the satellite cell and/or an absence of the extracellular cues necessary to sufficiently accelerate satellite cell division. (usda.gov)
- However, more research is needed to clarify potential mechanisms and benefits of increased satellite cell numbers. (nutraingredients.com)
- "More data are needed to examine how increasing dietary protein intake mechanistically affects satellite cell turnover and if protein-induced increases in satellite cell number provide any added benefit to resistance-trained individuals (i.e., reducing recovery time between training bouts due to satellite cell-mediated recovery mechanisms)," wrote the researchers. (nutraingredients.com)
- It was initially proposed that satellite cell proliferation and differentiation were only required to support resistance exercise-induced hypertrophy. (springer.com)
- Farup J, Rahbek SK, Knudsen IS, de Paoli F, Mackey AL, Vissing K. Whey protein supplementation accelerates satellite cell proliferation during recovery from eccentric exercise. (springer.com)
- Our results show that total body irradiation alters intracellular signaling and epigenetic pathways regulating cell proliferation and differentiation of skeletal muscle and adipose progenitor cells and provide a possible mechanism by which irradiation used in cancer treatment increases the risk for metabolic disease later in life. (diabetesjournals.org)
- SC are in a quiescent state throughout adulthood, but undergo multiple cycles of proliferation and self-renewal in response to muscle damage. (clinicaltrials.gov)
- Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury. (abcam.com)
- This inflammatory response is followed by muscle repair, regeneration and growth, which involves activation and proliferation of satellite cells, followed by their terminal differentiation [ 6 ]. (medsci.org)
- Critical limb ischaemia in adult human skeletal muscle increases satellite cell proliferation but not differentiation. (royalfree.nhs.uk)
- Short hairpin RNA (shRNA)-mediated knockdown of Gαi2 in satellite cells (SCs) leads to defective satellite cell proliferation, fusion, and differentiation ex vivo . (asm.org)
- For instance, Notch signaling is involved in fate determination and regulates satellite cell proliferation, and previous studies have shown that physical exercise increases the expression of Notch signaling pathway components-including ligands, Notch receptor, and downstream effectors-in myogenic cells [ 8 - 10 ]. (hindawi.com)
- This is because the degree to which we place mechanical stress on our muscles is in direct relation to the disruption of muscle cell organelles, the proliferation of satellite cells, and, ultimately, muscle hypertrophy-an increase in a muscle fiber's size. (bodybuilding.com)
- In fact, it's been suggested that it contributes to muscle hypertrophy by stimulating the proliferation of satellite cells. (bodybuilding.com)
- Data show that mature tissues in the stump (e.g., bone, cartilage, and skeletal muscle) respond to amputation by disorganization, histolysis, and increased cellular proliferation. (rupress.org)
- Regeneration of adult skeletal muscle is an asynchronous process requiring the activation, proliferation and fusion of satellite cells, to form new muscle fibres. (biologists.org)
- S1P is a lipid signaling molecule that controls the movement and proliferation of many human cell types. (newswise.com)
- Autophagy, Apoptosis, and Cell Proliferation in Exstrophy-Epispadias Complex. (abcam.com)
- miR-133 enhances myoblast proliferation by repressing serum response factor (SRF) mIR-133 suppresses SP1 expression In rats, miR-133b is expressed in retinal dopaminergicamacrine cell, and this expression is significantly increased during early stage during retinal degeneration. (wikipedia.org)
- meanwhile, the performance of these cells' proliferation and differentiation were analyzed. (peerj.com)
- Both cell lines will become the ideal tools to learn the mechanism of fish MSCs proliferation, differentiation and regeneration during muscle development in the future. (peerj.com)
- MSCs are a heterogeneous population of stem and progenitor cells originated from embryonic mesoderm, and their activation, proliferation and differentiation are the crucial basis for the muscle hyperplasic and hypertrophic growth. (peerj.com)
- Moreover, we show that muscle hypertrophy after pharmacological blockade of this pathway occurs without significant satellite cell proliferation and fusion to myofibers and without an increase in the number of myonuclei per myofiber. (pnas.org)
- ED2+ macrophages increase selectively myoblast proliferation in muscle cultures. (semanticscholar.org)
- Proliferation of Human Primary Myoblasts Is Associated with Altered Energy Metabolism in Dependence on Ageing In Vivo and In Vitro. (thefreelibrary.com)
- It has been demonstrated that aged satellite cells express S100B, an antimyogenic protein stimulating proliferation but inhibiting differentiation . (thefreelibrary.com)
- Likewise, methods to assess muscle morphology, fibertype composition and MHC distribution will be presented, along with a number of cellular and molecular analysis methods including measurements of mRNA expression, satellite cell activation/proliferation and compartmental glycogen localization/depletion. (sdu.dk)
- Lifeline® offers antimicrobials and phenol red, but they are not required for eukaryotic cell proliferation. (qingyuanbio.com)
- For the evaluation of SC proliferation, these cultivated cells were immunostained with Pax7 and bromodeoxyuridineassessed simultaneously. (researchsquare.com)
- Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds. (helsinki.fi)
- Cells in the superficial and middle layers are considered to be progenitor cells with high proliferation capability and differentiation potential. (thefreelibrary.com)
- ii) to evaluate which molecular markers which had been described for satellite cell and stem cell identification in different cell states (quiescence, activated or differentiated) are the most useful for studies on human skeletal muscle. (diva-portal.org)
- However, stem cells from a variety of other origins are also reported to contribute to myofibers upon engraftment into muscles, questioning whether satellite cells are the only stem cell source for muscle regeneration. (biologists.org)
- The implications of our results for muscle stem cell-based therapy are discussed. (biologists.org)
- Every cell has thousands of different areas of damage in their DNA, and it is becoming apparent that the damage in stem cell populations is cloned out into tissues . (fightaging.org)
- The authors of the open access paper here are quite ready to theorize a connection between stem cell mutation level and age-related declines in muscle mass and strength, but their data only shows a correlation. (fightaging.org)
- We have seen how a healthy 70-year-old has accumulated more than 1,000 mutations in each stem cell in the muscle, and that these mutations are not random but there are certain regions that are better protected. (fightaging.org)
- Cell Stem Cell 25:54-68.e5 (2019). (abcam.com)
- The Impact of Aerobic Exercise on the Muscle Stem Cell Response. (bioportfolio.com)
- All satellite cells express the stem-cell-specific transcription factor, paired-box 7 (Pax7). (hindawi.com)
- Dedifferentiation of stump tissues, such as skeletal muscle, precedes blastema formation, but it was not known whether dedifferentiation involves stem cell activation. (rupress.org)
- 1996 ). MyoD is required for myogenic stem cell function in adult skeletal muscle. (biologists.org)
- We have seen how a healthy 70-year-old has accumulated more than 1,000 mutations in each stem cell in the muscle, and that these mutations are not random, but there are certain regions that are better protected," says Maria Eriksson, professor in the Department of Biosciences and Nutrition at Karolinska Institutet. (medicalxpress.com)
- Embryonic stem cell-somatic cell fusion and postfusion enucleation. (biomedsearch.com)
- The limbal epithelial stem cell niche provides a unique, physically protective environment in which limbal epithelial stem cells reside in close proximity with accessory cell types and their secreted factors. (biomedsearch.com)
- Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. (abcam.com)
- Nevertheless, if skeletal muscle possesses a stem cell compartment it is not clear why the muscle fails to regenerate under pathological conditions. (nih.gov)
- Either the resident muscle stem cells are too rare or intrinsically incapable of repairing major damage, or perhaps the injured/pathological muscle is a prohibitive environment for stem cell activation and function. (nih.gov)
- Although we lack definitive answers, recent experimental evidences suggest that the mere presence of endogenous stem cells may not be sufficient to guarantee muscle regeneration, and that the presence of appropriate stimuli and factors are necessary to provide a permissive environment that permits stem cell mediated muscle regeneration and repair. (nih.gov)
- In this review we discuss the molecular basis of muscle regeneration and how aging impacts stem cell mediated muscle regeneration and repair. (nih.gov)
- Cell Stem Cell. (wikipedia.org)
- A new look at the origin, function, and 'stem-cell' status of muscle satellite cells. (semanticscholar.org)
- Finally, clinical situations are outlined where there is a need to enhance skeletal muscle regeneration: these include acute and chronic injuries or transplantation with bioengineering to form new muscles, therapeutic approaches to muscular dystrophies, and comment on proposed stem cell therapies to reduce age-related loss of muscle mass and function. (nih.gov)
- The stem cell method is also capable of growing many more cells from a smaller starting batch than the previous biopsy method. (kurzweilai.net)
- MyoCult™-SF Expansion Supplement Kit (Human) contains a serum-free supplement and attachment substrate for the culture of primary human skeletal muscle progenitor cells (myoblasts) and human pluripotent stem cell (hPSC)-derived myoblasts. (stemcell.com)
- Recent years, stem cell-based therapy has aroused a great attention. (thefreelibrary.com)
Adult skeletal muscle3
- We observed very few (up to 1.3%) active satellite cells in healthy adult skeletal muscle at rest, but they increased significantly (up to 7-fold) following muscle activity. (diva-portal.org)
- Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. (jove.com)
- 1993 ). Selective accumulation of MyoD and myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones. (biologists.org)
- Ultimately, the identification of genes associated with skeletal muscle mass regulation continue to progress this field of research aiming to optimise the growth response to resistance exercise and help prevent muscle wasting. (nature.com)
- However, satellite cells may also play a role in muscle fibre remodelling after endurance-based exercise and extracellular matrix regulation. (springer.com)
- Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy. (springer.com)
- Transcriptional regulation of Hepatic Stellate Cell activation in NASH. (abcam.com)
- Skeletal muscle plays a paramount role in the regulation of insulin-mediated glucose uptake. (diabetesjournals.org)
- These results indicate the effects of resistance exercise on the regulation of satellite cells and provide insight into the molecular mechanism of satellite cell activation following physical exercise. (hindawi.com)
- Exercise positively affects muscle fiber composition via regulation of satellite cells to improve muscle performance. (hindawi.com)
- Altered activation of PI3K and SREBP-1c may explain the defective regulation of miR-1 and miR-133a expression in response to insulin in muscle of type 2 diabetic patients. (wikipedia.org)
- Charge, S.B. and Rudnicki, M. A. (2004) Cellular and molecular regulation of muscle regeneration. (scirp.org)
- The purpose of the present review is to give a short overview of the currently known factors and their role in skeletal muscle plasticity. (biologists.org)
- Dr. Luden's research interests revolve around human skeletal muscle plasticity as it relates to athletic performance and healthy living. (jmu.edu)
- Further cellular and translational research is warranted to validate amino acid-mediated myeloid and myocellular mechanisms within skeletal-muscle functional plasticity. (physiology.org)
- Myofibrillar protein turnover may be an important component of muscle plasticity to exercise ( 23 ). (physiology.org)
- Together, these data provide some mechanistic insight, but the larger picture of the molecular and cellular processes linking protein/amino acid feeding to muscle recovery and functional plasticity requires 'omic-scale investigation. (physiology.org)
- The introduction of immunohistochemistry and the discovery of molecular markers of satellite cells then made them accessible for light microscopic studies and a wealth of information is today available. (diva-portal.org)
- Here we review the molecular mechanisms controlling the activation of satellite cells in response to mechanical stress and protein intake in both in vitro and in vivo models. (springer.com)
- 1 Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany. (jci.org)
- The study noted here provides numbers for the mutation rates in muscle stem cells , the stochastic damage that occurs over time as small numbers of errors slip past the highly efficient molecular machinery of cellular replication and DNA repair . (fightaging.org)
- We currently have a good descriptive understanding of the molecular mechanisms controlling the muscle phenotype. (biologists.org)
- Physical activity and molecular ageing presumably interact to precipitate musculoskeletal decline in humans with age. (prolekare.cz)
- We conclude that human muscle age-related molecular processes appear distinct from the processes regulated by those of physical activity. (prolekare.cz)
- Human Molecular Genetics 2013, 22 (23), 4739-4747. (ncl.ac.uk)
- More specifically, he is interested in how nutritional and training strategies can be manipulated to create optimal cellular and molecular environments (satellite cell physiology, energetics, and fiber size) for recovery, adaptation and ultimately performance. (jmu.edu)
- We are capitalizing on CyTOF analysis to investigate dynamic cellular and molecular properties of stem and progenitor populations for the elucidation of regulatory networks that underlie cell state transitions in aging and muscle diseases. (ca.gov)
- Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. (physiology.org)
- This study investigated the effect and underlying molecular mechanism of micronized sacchachitin(mSC) on satellite cells (SCs), which are known as the muscle stem cells. (researchsquare.com)
- Here is how it works: molecular distress signals such as associated with injuries, inflammation, or cell senescence, trigger the partial regression of normal mature body cells back to earlier less differentiated epigenetic states. (anti-agingfirewalls.com)
- Authentication of the myogenicity of these stem/progenitor cells is based either on transplantation after fluorescent activated cell sorting (FACS) or in vitro culture. (biologists.org)
- Several cell types with different characteristics and tissues of origin, including myogenic stem and progenitor cells, stromal cells, and pluripotent stem cells, have been investigated over the years and have recently entered in the clinical arena with mixed results. (jci.org)
- Progenitor cells, including skeletal muscle satellite cells, are more sensitive to ionizing radiation than their differentiated counterparts ( 8 ). (diabetesjournals.org)
- In this study, we tested the hypothesis that ionizing radiation induces chronic alteration of the epigenome of skeletal muscle and adipose progenitor cells. (diabetesjournals.org)
- We determined whether ionizing radiation alters whole-body glucose homeostasis and reprograms metabolic progenitor cells. (diabetesjournals.org)
- We investigated the therapeutic activity and mechanistic targets of saphenous vein-derived pericyte progenitor cells (SVPs) in a mouse myocardial infarction (MI) model. (ahajournals.org)
- 1 Clinical trials showed that administration of bone marrow-derived progenitor cells (PCs) improves left ventricular (LV) function in patients with coronary artery disease. (ahajournals.org)
- Pigment epithelium-derived factor (PEDF) peptide promotes the expansion of hepatic stem/progenitor cells via ERK and STAT3-dependent signaling. (abcam.com)
- This medium has been optimized for the derivation and expansion of human skeletal muscle progenitor cells in vitro. (stemcell.com)
- Supports derivation and long-term expansion of human skeletal muscle progenitor cells under serum-free conditions. (stemcell.com)
- Dysregulated Extracellular Matrix Remodeling Of Aged Human Skeletal Muscle Following Damaging Exercise. (lww.com)
- The mechanical properties of extracellular matrix proteins strongly influence cell-induced tension in the matrix, which in turn influences cell function. (biomedsearch.com)
- In mdx mouse muscle, which displays persistent regeneration, FGF levels in the extracellular matrix are higher than those in controls. (sciencemag.org)
- With advancing age, a loss of muscle mass and strength is observed (sarcopenia), increasing the risk of falls, fractures and mortality [ 2 ]. (mdpi.com)
- Loss of skeletal muscle mass, known as sarcopenia, is a serious health issue that affects millions of aging adults. (hindawi.com)
- J Cachexia Sarcopenia Muscle. (harvard.edu)
- Ageing is associated with a progressive loss of skeletal muscle mass and strength referred to as sarcopenia [1, (thefreelibrary.com)
- Sarcopenia can also be envisaged as an age-dependent impairment of processes responsible for maintenance and repair of the muscle in response to contraction-induced injury [7- (thefreelibrary.com)
- Newswise - TEMPE, Ariz. - By understanding the secret of how lizards regenerate their tails, researchers may be able to develop ways to stimulate the regeneration of limbs in humans. (newswise.com)
- Lizards are the most closely-related animals to humans that can regenerate entire appendages. (newswise.com)
- Mammalian skeletal muscle has the ability to regenerate and repair in response to exercise or injury. (asm.org)
- The ability of muscles to regenerate themselves is attributed to the presence of a form of adult stem cells called "satellite cells" that are essential for muscle repair. (newswise.com)
- Adult cardiac muscle, unlike skeletal muscle, lacks the ability to regenerate after ischemic injury, and death of cardiomyocytes promotes a cascade that results in heart failure. (ahajournals.org)
- Creatine accumulates in muscle cells, creating a reservoir of phosphate ions which are able to regenerate ATP within the cells. (mrsupplement.com.au)
- The capacity of skeletal muscles to repair and regenerate declines during aging in humans, and this decline may lead to muscle loss and frailty. (sciencemag.org)
- Massage can improve muscle function, resulting in less swelling and fewer signs of inflammation after exercise. (whole9life.com)
- The purpose of this study is to evaluate the potential beneficial effects of RES supplementation on inflammation and regeneration in skeletal muscle after a contusion injury, in comparison to a conventional treatment of nonsteroidal anti-inflammatory drugs (NSAID). (medsci.org)
- Therefore, inflammation is the best target for the development of effective treatments in the recovery of injured muscles [ 5 ]. (medsci.org)
- Within hours of muscle injury, neutrophils and macrophages-white blood cells critical to decreasing inflammation-infiltrate your injured muscle. (bodybuilding.com)
- The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation. (abcam.com)
- Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. (nsca.com)
- Therefore, interfering with training-induced inflammation (i.e., delayed-onset muscle soreness (DOMS)) will stunt your gains. (startingstrength.com)
- Exercise-induced muscle damage (EIMD) manifests as muscle soreness, inflammation, and reductions in force generating capacity that can last for several days after exercise. (humankinetics.com)
- ACUTE INFLAMMATION (NSAIDS) There is rising evidence that dampening acute inflammation impairs muscle growth and regeneration in animal and human models.2 Despite this fact, clinicians are often quick to recommend NSAIDs to address acute inflam- mation due to their ability to decrease pain and reduce inflammation via their impact on cyclooxygenase-2 (COX-2) enzymes. (advanceweb.com)
- We have also been deeply concerned with understanding certain processes of aging which we have regarded to be deleterious and worth fighting, including inflammation and the SASP, what happens when old senescent cells do not go away but instead become bad citizens. (anti-agingfirewalls.com)
- Based on that observation, I became convinced that S1P signaling played an important role in muscle stability and homeostasis, not just in flies but in mammals, including humans. (newswise.com)
- Homeostasis of the skeletal muscle is mediated by skeletal stem cells, also known as satellite cells (SCs). (researchsquare.com)
- A team of researchers from the U.S. and Germany describes a novel CRISPR approach to produce healthy heart muscle using pluripotent stem cells from Duchenne muscular dystrophy (DMD) patients. (medicalxpress.com)
- The resulting cell hybrids have been shown to have similar properties to pluripotent cells. (biomedsearch.com)
- Up to now, SCNT is the main way to generate gene-targeted pigs, since germ line-competent pluripotent stem cells are not available for this species. (biomedsearch.com)
- Biomedical engineers at Duke University have grown the first functioning human skeletal muscle from human induced pluripotent stem cells (iPSCs). (kurzweilai.net)
- In the study, the researchers started with human induced pluripotent stem cells. (kurzweilai.net)
- The researchers could also, in theory, fix genetic malfunctions in the induced pluripotent stem cells derived from a patient, he added. (kurzweilai.net)
Mammalian skeletal muscle1
- The exercise-induced stimulus from resistance exercise activates a complex response of cellular messaging pathways, cytokines and hormones that set muscle hypertrophy in motion (see Figure 2). (ideafit.com)
- The main finding in the present study was that the NSAID infusion for 7.5 h during the exercise day suppressed the exercise-induced increase in the number of satellite cells 8 days after exercise. (rxmuscle.com)
- Kendall, B. and Eston, R. (2002) Exercise-induced muscle damage and the potential protective role of estrogen. (scirp.org)
- These exercise-induced myokines are believed to mediate crosstalk between skeletal muscle and other organ compartments. (mcponline.org)
- Satellite cells (SCs) are the main muscle stem cells responsible for its regenerative capacity. (nature.com)
- It has a high regenerative capacity after injury, which is directly linked to the presence of satellite cells (SCs). (nature.com)
- show that experimental activation of Notch signaling is sufficient to reverse the age-related decline in muscle regenerative capacity. (sciencemag.org)
- While muscle stem cells (MuSCs) have a remarkable capacity to maintain and repair skeletal muscle throughout adulthood, they decline in regenerative capacity during aging. (ca.gov)
- Satellite cells in muscles contribute nuclei to myofibers damaged during intense exercise for repair, and the availability of satellite cells determine the resilience of muscle against physical challenges. (nutritionaloutlook.com)
- Finally, we show that genetic ablation of Acvr2b , which encodes a high-affinity receptor for myostatin and activin A specifically in myofibers is sufficient to induce muscle hypertrophy. (pnas.org)
- In response to muscle damage or under increased workload these cells activate, migrate into damaged sites, proliferate, and fuse with existing myofibers or with each other to form new myofibers, whereas a small portion of these cells returns into quiescence [11, (thefreelibrary.com)
- Contrasts in muscle and myofibers of elite male and female bodybuilders' J Appl Physiol. (fittoday.ru)
- Regardless of total protein deficiency, this mouse shows a mild phenotype, with comparatively moderate muscle pathology. (nature.com)
- The skeletal muscle phenotype is subject to considerable malleability depending on use as well as internal and external cues. (biologists.org)
- 10 Mouse MSC-like cells converted to a myogenic phenotype after infusion and homing to cardiotoxin injured skeletal muscle. (ahajournals.org)
- Furthermore, the majority of macrophages in non-injured human skeletal muscle show a 'mixed' M1/M2 phenotype, expressing CD11b, CD14, CD68, CD86 and CD206. (bio-protocol.org)
- Overabundance of matrix FGF in mdx muscles may be related to an increase in both satellite cell and regenerative activity in the dystrophic muscle and may help explain the benign phenotype of mdx animals compared with the genetically identical human Duchenne muscular dystrophy. (sciencemag.org)
- We are interested in the dynamic interplay in which physical cues from the microenvironment alter cell phenotype, and cells feedback to modify those very same cues. (jmu.edu)
- Thus, the increasing evidence indicates resetting of the regulatory systems that lead to altered phenotype of satellite cells in aged muscles. (thefreelibrary.com)
- Lifeline® Skeletal Muscle Cells are stem cells isolated from neonatal skeletal muscle, and cryopreserved as tertiary cells to ensure optimal phenotype and the highest viability and plating efficiency. (qingyuanbio.com)
- We concluded that dystrophic muscles, independently of their degeneration degree, retain their SCs pool with proliferating and regenerative capacities. (nature.com)
- In this Review, we do a roundup of the past attempts and describe the updated status of cell-based therapies aimed at counteracting the skeletal and cardiac myopathy present in dystrophic patients. (jci.org)
- 1984 ). Myosatellite cells, growth, and regeneration in murine Dystrophic muscle: A quantitative study. (biologists.org)
- Skeletal muscle specific knockout of DEP domain-containing 5 increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration. (utmb.edu)
- Isolation of crude mitochondrial fraction from cells. (biomedsearch.com)
- Interestingly, satellite cells from old muscles also display dysregulation of genes controlling mitochondrial and glycolytic enzymes . (thefreelibrary.com)
- Successful skeletal muscle regeneration depends on a functional pool of muscle stem cells, termed satellite cells (SC). (clinicaltrials.gov)
- As a consequence, muscle structural and functional modifications can be achieved by an almost unlimited combination of inputs and downstream signaling events. (biologists.org)
- A study recently published in the Journal of Functional Foods found that a proprietary combination of Panax notoginseng and Rosa roxburghii (ActiGin), from NuLiv Science (Brea, CA), restored human muscle satellite cells following exercise. (nutritionaloutlook.com)
- Preserving skeletal muscle mass and functional capacity is essential for healthy ageing. (mdpi.com)
- The following instructions generate a high-purity subfraction of functional and culturable satellite cells. (miltenyibiotec.com)
- Isolate functional satellite cells by depleting non-target cells with the Satellite Cell Isolation Kit. (miltenyibiotec.com)
- 2013. Adeno-associated virus 9 mediated FKRP gene therapy restores functional glycosylation of α-dystroglycan and improves muscle functions . (cardiff.ac.uk)
- CD11b and CD206 IHC in muscle also reveals distinct morphological features of macrophages that may be related to the functional status of these cells. (bio-protocol.org)
- Umnova, M. and Seene, T. (1991) The effect of increased functional load on the activation of satellite cells in the skeletal muscle of adult rats. (scirp.org)
- The myofibrils are composed of actin and myosin filaments, repeated in units called sarcomeres, which are the basic functional units of the muscle fiber. (wikipedia.org)
Roles in skeletal muscle1
Regeneration of skeletal muscle3
- Carlson BM (1973) The regeneration of skeletal muscle. (springer.com)
- Regeneration of skeletal muscle is mainly executed by satellite cells (SCs) ( 8 ). (asm.org)
- Skeletal-muscle-specific stem cells, termed satellite cells, contribute to the postnatal maintenance, growth, repair, and regeneration of skeletal muscle [ 1 ]. (hindawi.com)
- Other markers such as DLK1/FA1, a member of the EGF-like family and c-Met, the receptor for hepatocyte growth factor showed that satellite cell heterogeneity in human muscle is far greater than previously shown. (diva-portal.org)
- In a comparative human study, we investigated the muscle fiber type-specific association between emergence of satellite cells (SCs), muscle growth, and remodeling in response to 12 wk unilateral resistance training performed as eccentric (Ecc) or concentric (Conc) resistance training ± whey protein (Whey, 19.5 g protein + 19.5 g glucose) or placebo (Placebo, 39 g glucose) supplementation. (forskningsdatabasen.dk)
- Insulin-like growth factor-I E peptides: implications for aging skeletal muscle. (biomedsearch.com)
- In skeletal muscle there is good evidence to suggest that locally produced insulin-like growth factor-1 (IGF-I), rather than circulating IGF-I, is important in regard to muscle mass maintenance, repair and hypertrophy. (biomedsearch.com)
- Muscle growth is further supported by DNA recruitment through activation and incorporation of satellite cells. (biologists.org)
- How the body responds to muscular overload to elicit muscle growth is still under much scientific investigation. (ideafit.com)
- Significantly, some anabolic (muscle growth-promoting) hormones-including insulin-like growth factor, testosterone and growth hormone-play a primary role in promoting hypertrophy (Schoenfeld 2010). (ideafit.com)
- Fogelholm, G.M., Näveri, H.K., Kiilavuori, K.T. and Härkönen, M.H. (1993) Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters. (scirp.org)
- Backward elimination and principal component regression evaluated the statistical significance of proposed circulating anabolic hormones (e.g., testosterone, free testosterone, dehydroepiandrosterone, dihydrotestosterone, insulin-like growth factor-1, free insulin-like growth factor-1, luteinizing hormone, and growth hormone) and RET-induced changes in muscle mass ( n = 49). (frontiersin.org)
- Satellite cells are indispensable for skeletal muscle repair and regeneration and are associated with muscle growth in humans. (bioportfolio.com)
- However, the requirement for Gαi isoforms in skeletal muscle growth and regeneration has not been determined. (asm.org)
- Muscle growth is definitely the result of hard training, precise nutrition, consistency, and adequate rest, but it's also the result of much deeper interactions at the cellular level. (bodybuilding.com)
- Let's take an intimate look at what happens inside the body to instigate muscle growth, and how you can maximize your own gains! (bodybuilding.com)
- But an often-overlooked part of the muscle-growth process is the combined effect of growth factors and anabolic hormones in the process. (bodybuilding.com)
- Closely related to insulin and highly anabolic, IGF-1 is a key regulator of muscle growth. (bodybuilding.com)
- The growth of a plant cell encompasses a complex set of subcellular components interacting in a highly coordinated fashion. (biomedsearch.com)
- Placental Stem Villus Arterial Remodeling Associated with Reduced Hydrogen Sulfide Synthesis Contributes to Human Fetal Growth Restriction. (abcam.com)
- Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. (nsca.com)
- Myostatin (MSTN) is a transforming growth factor-β family member that acts as a negative regulator of skeletal muscle mass. (pnas.org)
- Polyclonal antibody F547 reacts with a bovine basic fibroblast growth factor (bFGF) and a human recombinant bFGF, but not with bovine acidic fibroblast growth factor. (sciencemag.org)
- In this work we set out to determine if the murine macrophage J774 cell line can be used to produce myogenic growth factors. (semanticscholar.org)
- Gene expression was regulated by protein-leucine in a dose-dependent manner affecting the inflammatory response and muscle growth and development. (physiology.org)
- Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication. (nih.gov)
- The changes in satellite cell properties coincided with the inactivation of Notch signaling and the activation of Wnt signaling and likely involve modulation by transcription factors of the Sox family. (hindawi.com)
- The right anabolic conditions must be in place before satellite cell activation can begin. (bodybuilding.com)
- It involves the ability of S1P to activate S1P receptor 2, one of its five cell surface receptors, leading to downstream activation of an inflammatory pathway controlled by a transcription factor called STAT3. (newswise.com)
- S1P, acting through S1P receptor 2, leads to activation of STAT3, resulting in changes in gene expression that cause the satellite cell to leave its "sleeping" state and start to proliferate and assist in muscle repair. (newswise.com)
- Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway. (abcam.com)
- The RNA signatures from multiple compounds all targeting serotonin, DNA topoisomerase antagonism, and RXR activation were significantly related to the muscle age-related genes. (prolekare.cz)
- The whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21-78 years) was analyzed, to study the specific connection between SC aging and muscle impairment. (lifeboat.com)
- An NSAID was infused via a microdialysis catheter into the vastus lateralis muscle of one leg (NSAID leg) before, during, and for 4.5 h after exercise, with the other leg working as a control (unblocked leg). (rxmuscle.com)
- Vastus lateralis muscle samples (30 and 240 min postexercise) underwent transcriptome analysis by microarray followed by bioinformatic analysis. (physiology.org)
Capacity of skeletal1
- Graduate students in the Muscle Biology lab enroll in the UTMB Rehabilitation Sciences PhD program. (utmb.edu)
- The Rehabilitation Sciences program has four research focus areas including the Muscle Biology of Rehabilitation track. (utmb.edu)
- Dr. Ted Graber working in the Muscle Biology Laboratory. (utmb.edu)
- A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) describes the biology behind why muscle stem cells respond differently to aging or injury. (medicalxpress.com)
- The peptides produced by the ghrelin gene, i.e., acylated ghrelin (AG), unacylated ghrelin (UnAG), and obestatin (Ob), affect skeletal muscle biology in several ways, not always with overlapping effects. (deepdyve.com)
- Embryonic stem (ES) cells are able to reprogram somatic cells following cell fusion. (biomedsearch.com)
- In the course of embryonic development, muscle is derived from the mesodermal layer of embryonic germ cells. (newworldencyclopedia.org)
- Embryonic development occurs as a unidirectional progression from a single-cell zygote to an adult organism. (anti-agingfirewalls.com)
- Human skeletal muscle satellite cells are activated in response to both resistance and endurance exercise. (springer.com)
- Petrella JK, Kim J, Mayhew DL, Cross JM, Bamman MM. Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis. (springer.com)
- When studied at the mRNA level these three transcripts are known to be upregulated in the muscles of elderly people following high resistance exercise, albeit with different time courses. (biomedsearch.com)
- Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy. (nih.gov)
- To date, the most potent intervention to mitigate disuse-induced muscle deterioration is mechanical loading in the form of resistance exercise. (mdpi.com)
- Muscle protein anabolic resistance to essential amino acids does not occur in healthy older adults before or after resistance exercise training. (utmb.edu)
- The development of insulin resistance and type 2 diabetes (T2D) involves a complex array of metabolic defects in skeletal muscle. (diva-portal.org)
- The primary aim of this study is to investigate the effects of BEP-treatment on the skeletal musculature in testicular cancer patients, and to examine whether the expected treatment-induced muscular deterioration can be attenuated or even reversed by high intensity progressive resistance training (HIPRT). (biomedcentral.com)
- To cope with this, it possesses a tremendous capacity for rapid and effective repair that is widely held to be accomplished by the satellite cells lying between the muscle fiber plasmalemma and the basement membrane. (biologists.org)
- Although they might provide potential sources for cell therapy of debilitating muscular dystrophies, their relevance to normal physiological muscle repair has not yet been established. (biologists.org)
- With myocardial infarction (MI) remaining a major cause of morbidity and mortality worldwide, cell therapy now aims to offer a novel option for cardiac repair. (ahajournals.org)
- Our results suggest that resveratrol combined with NSAID potentially improve muscle recovery and may be a potential candidate for further development as an effective clinical treatment for muscle repair. (medsci.org)
- Interactions between the immune system and skeletal muscle play a key role in controlling the progress of both the contusion injury and subsequent muscle repair. (medsci.org)
- This is how they become new muscle protein strands and assist with muscle repair. (bodybuilding.com)
- Newswise - May 14, 2012 - Oakland, Calif. - A study conducted by Children's Hospital & Research Center Oakland scientists identifies how skeletal muscle stem cells respond to muscle injury and may be stimulated to improve muscle repair in Duchenne Muscular Dystrophy, a severe inherited disease of muscle that causes weakness, disability and, ultimately, heart and respiratory failure. (newswise.com)
- The study, led by Julie D. Saba, MD, PhD, senior scientist at Children's Hospital Oakland Research Institute (CHORI), shows that a lipid signaling molecule called sphingosine-1-phosphate or "S1P" can trigger an inflammatory response that stimulates the muscle stem cells to proliferate and assist in muscle repair. (newswise.com)
- Although patients with Duchenne Muscular Dystrophy start out life with enough satellite cells to repair the patients' degenerating muscles, over time the satellite cells fail to keep up with the rate of muscle degeneration. (newswise.com)
- contains several constituents, including Sacacchin, which has recently drawn attention because it can not only enhance the repair of muscle damagebut also strengthen themuscle enforcement. (researchsquare.com)
- These keys include DNA repair, effective mobilization of stem cells, and the possibility of restoring cells to earlier epigenetic states. (anti-agingfirewalls.com)
- Given that muscle satellite cells contribute to regeneration of muscle under various stressors like exercise or muscle damage ( 16 - 19 ), modulation of DNA methylation in satellite cells may alter long-term muscle function. (diabetesjournals.org)
- In this study, we aim to investigate if NR+PT supplementation will promote skeletal muscle regeneration after muscle damage in elderly humans by enhanced recruitment of SC. (clinicaltrials.gov)
- 14 days after start of placebo or NR/PT (500/100 mg twice daily) supplementation a muscle damage will induced in the m. vastus lat. (clinicaltrials.gov)
- It produces a much more detailed view of the state of nuclear DNA inside a cell population, showing the enormous variations in stochastic mutational damage that takes place over the years. (fightaging.org)
- One can look at the numbers for mutational damage in old cells and it sounds fairly horrific out of context, but everything irelated cells and cellular biochemistry involves huge numbers. (fightaging.org)
- However: at present there is no compelling causal evidence to show that nuclear DNA damage alone has a significant effect over the present human life span in comparison to other contributions to degenerative aging. (fightaging.org)
- Cyclic compression of muscles after intense exercise reduce swelling and muscle damage. (whole9life.com)
- Seene, T. and Kaasik, P. (2013) Muscle damage and regeneration: Response to exercise training. (scirp.org)
- Fridén, J., Leiber, R.L. and Thornell, L.E. (1991) Subtle indications of muscle damage following eccentric contractions. (scirp.org)
- Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. (humankinetics.com)
- When a child's muscles are already withering away from something like Duchenne muscular dystrophy, it would not be ethical to take muscle samples from them and do further damage," explained Nenad Bursac , professor of biomedical engineering at Duke University and senior author of an open-access paper on the research published Tuesday, January 9, in Nature Communications . (kurzweilai.net)
- In humans, improved muscle performance following postexercise protein or amino acid ingestion was associated with increased myofibrillar protein fractional synthesis rate (FSR) in the first 3-4 h postexercise ( 11 , 24 ) and evidence for reduced muscle damage 24-48 h later (lower blood creatine kinase) ( 42 , 56 , 60 , 66 ). (physiology.org)
- The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes. (helsinki.fi)
- The scientists used a chemical compound that's an NAD+ booster called NMN which plays a critical role in repairing cellular DNA as well as maintaining cell vitality to test what would happen. (lifeboat.com)
- Dig deeper and see how muscle is built on a cellular level! (bodybuilding.com)
- and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
- Over the past decade, cardiac cellular transplantation techniques have made significant gains, and a variety of cell types have been proposed as useful candidates (see review 1 ). (ahajournals.org)
- Creatine is an amino acid and it is stored mainly in skeletal muscles complexed with phosphate ions, which it uses to replenish cellular stores of ATP, the molecule that supplies the muscles with rapid energy (2). (mrsupplement.com.au)
- The cellular targets for myostatin and activin A in muscle and the role of satellite cells in mediating muscle hypertrophy induced by inhibition of this signaling pathway have not been fully elucidated. (pnas.org)
- To delineate the cellular hierarchy in human skeletal muscle and determine signaling networks that are disregulated in aged muscle stem cells (MuSC, defined as Lin- CD34+ CD20+ a7integrin+). (ca.gov)
- The Physical Exercise and Prostate Cancer (PEPC) trial is designed to determine the effectiveness of strength training on clinical and muscle cellular outcomes in non-metastatic prostate cancer patients after high-dose radiotherapy and during ongoing androgen deprivation therapy. (pubmedcentralcanada.ca)
- The findings from the PEPC trial will provide new knowledge on the effects of high-load strength training on clinical and muscle cellular outcomes in prostate cancer patients during androgen deprivation therapy. (pubmedcentralcanada.ca)
- Stem cells are defined by three important characteristics: the ability to self-renew, to form clonal populations and to differentiate into different cell types. (medsci.org)
- In order to achieve this, the awardee will identify novel subsets of MuSC using multidimensional single-cell mass cytometry and then subsequently evaluate the specific cell populations' expression and properties at different periods of human aging. (ca.gov)
- The prospective isolation and culture expansion of pericytes brought great excitement as it opened the way to the therapeutic use of well-defined cell populations with known regenerative potential to overcome concerns associated with the use of traditional MSC preparations. (springer.com)
- Methods and Results - A small bone marrow aspirate was taken from the iliac crest of healthy human volunteers, and hMSCs were isolated as previously described. (ahajournals.org)
- Such a cell population might be found in the adult bone marrow. (ahajournals.org)
- For example, a murine MSC population isolated from mouse bone marrow and injected into the quadriceps of the mdx mouse demonstrated that the cells could locally contribute dystrophin to the muscle fiber sarcolemma. (ahajournals.org)
- Skeletal muscle, also known as "striated muscle" or "voluntary muscle," is anchored (with some exceptions) by tendons to bone and is used to affect skeletal movement such as locomotion and in maintaining posture (the tongue is an example of a skeletal muscle that lacks bony supports). (newworldencyclopedia.org)
- Clinical outcomes are body composition (lean body mass, bone mineral density and fat mass) measured by Dual-energy X-ray Absorptiometry, serological outcomes, physical functioning (muscle strength and cardio-respiratory fitness) assessed with physical tests and psycho-social functioning (mental health, fatigue and health-related quality of life) assessed by questionnaires. (pubmedcentralcanada.ca)