A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Therapeutic act or process that initiates a response to a complete or partial remission level.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
The return of a sign, symptom, or disease after a remission.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Transplantation of an individual's own tissue from one site to another site.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Tissue ablation of the PROSTATE performed by ultrasound from a transducer placed in the RECTUM. The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Vomiting caused by expectation of discomfort or unpleasantness.
Antibodies obtained from a single clone of cells grown in mice or rats.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Infections with fungi of the genus ASPERGILLUS.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Partial or total surgical excision of the tongue. (Dorland, 28th ed)
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
An anti-inflammatory 9-fluoro-glucocorticoid.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Infection in humans and animals caused by fungi in the class Zygomycetes. It includes MUCORMYCOSIS and entomophthoramycosis. The latter is a tropical infection of subcutaneous tissue or paranasal sinuses caused by fungi in the order Entomophthorales. Phycomycosis, closely related to zygomycosis, describes infection with members of Phycomycetes, an obsolete classification.
Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
The ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutation.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Elements of limited time intervals, contributing to particular results or situations.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Therapy with two or more separate preparations given for a combined effect.
An anthracenedione-derived antineoplastic agent.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
Tumors or cancer of the PROSTATE.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Antibodies produced by a single clone of cells.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
The inferior part of the lower extremity between the KNEE and the ANKLE.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
An organoplatinum compound that possesses antineoplastic activity.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
A decrease in the number of NEUTROPHILS found in the blood.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Antimetabolites that are useful in cancer chemotherapy.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.

Second-line treatment for primary central nervous system lymphoma. (1/1778)

Failure after first-line treatment was reported in 35-60% of immunocompetent patients with primary central nervous system lymphoma (PCNSL). There are currently no reports focusing on salvage therapy. This review analyses prognostic factors and the efficacy of salvage therapy by focusing on data from papers reporting results of first-line treatment in 355 cases. The study group consisted of 173 patients presenting treatment failure. The interval between failure and death (TTD) was compared for age at relapse (< or =60 vs. >60 years), type of failure (relapse vs. progression), time to relapse (< or =12 vs. >12 months) and salvage treatment (yes vs no). Median TTD was similar in younger and older patients (P = 0.09). Relapsed patients had a longer TTD than patients with progressive disease (P = 0.002). Early relapse led to a shorter TTD than late relapse (P = 0.005). Median TTD was 14 months for patients who underwent salvage therapy and 2 months for untreated cases (P<0.00001). A multivariate analysis showed an independent prognostic role for salvage therapy and time to relapse. Age and type of failure had no predictive value. Salvage therapy significantly improves outcome and, possibly, quality of life. As many different treatments were used conclusions cannot be made regarding an optimal treatment schedule.  (+info)

ESHAP as salvage therapy for refractory non-Hodgkin's lymphoma: Taiwan experience. (2/1778)

BACKGROUND: The ESHAP regimen, a combination of the chemotherapeutic drugs etoposide, methylprednisolone (solumedrol), high-dose cytarabine (ara-C) and cisplatin, has been shown to be active against refractory non-Hodgkin's lymphoma in therapeutic trials. We were interested in determining whether this regimen would be effective and tolerable for Chinese patients. METHODS: Thirty-two patients with refractory/relapsed non-Hodgkins lymphoma (23 intermediate-grade and nine high-grade) were enrolled in this study. Etoposide was administered at a dose of 40 mg/m2/day as a 1 h intravenous infusion from day 1 to day 4, solumedrol 500 mg/day was given as a 15 min intravenous infusion from day 1 to day 5, ara-C 2 g/m2 was given as a 2 h intravenous infusion on day 5 and cisplatin was given at a dose of 25 mg/m2/day as a continuous infusion from day 1 to day 4. Clinical efficacy and toxicity were assessed on the basis of the WHO criteria. RESULTS: Ten patients (31.3%, 95% Cl 15.2-47.4%) attained complete remission (CR) and seven had partial remission (PR). The overall response rate was 53.1% (95% Cl 35.8-70.4%). In eight of the 10 CR patients, the remission lasted for more than 8 months. The remaining two patients had CR of 5 and 6 months. The median duration of CR was 12.2 months (range 5-22 months). Myelosuppression with subsequent infections was the major toxicity. Severe leukopenia (WBC < 1000/microliter) lasted for an average of 12 days and thrombocytopenia (< 25,000/microliter) 18 days. One patient (3.1%) died of neutropenia-associated sepsis within 4 weeks after treatment. Non-myeloid toxicities included alopecia in 66% (28% grade 2, 22% grade 3), stomatitis in 72% (25% grade 2, 28% grade 3, 13% grade 4), hepatotoxicity in 9% (3% grade 2), renal toxicity in 13% (6% grade 2, 3% grade 3) and infection in 56% (18% grade 2, 25% grade 3, 13% grade 4). The majority of the responders relapsed within 2 years after ESHAP treatment. Median survival for all patients was 8.6 months. CONCLUSIONS: ESHAP is an active and tolerable regimen in Chinese patients with relapsed/refractory lymphoma, but the duration of remission is brief and without significant impact on survival.  (+info)

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma. (3/1778)

Transplantation after high-dose chemotherapy prolongs survival in patients with multiple myeloma compared with standard therapy. It is unclear whether the optimal timing of transplantation is immediately after induction chemotherapy or whether stem cells may be cryopreserved for transplantation at subsequent progression or relapse. In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma. One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved. Eleven had transplants early in the disease after they demonstrated failure to respond to primary therapy. The remaining 107 were eligible for transplants when there was evidence of progressive disease. Of the 118 patients, 67 had transplants, nine died of progressive disease before transplantation, and 42 remain alive in plateau phase. The median survival of the group is 58.5 months; 67 are alive. Serum beta2-microglobulin, bone marrow labeling index (S phase), and hemoglobin level predicted overall survival (P < 0.006, P < 0.001, and P < 0.01, respectively). We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma. The underlying biology of the disease has a greater impact on survival than the timing of transplantation. A prospective randomized trial is required to answer definitively the question of the optimal timing of blood cell transplantation.  (+info)

High-dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin. (4/1778)

Between 1985 and 1996, 51 patients with relapsed or refractory small cleaved cell lymphoma (SCCL) received high-dose chemotherapy +/- TBI in conjunction with autologous (ABMT) (36 patients) or allogeneic transplantation (15 patients). Patients were eligible for ABMT if the bone marrow biopsy done prior to the planned transplant did not reveal microscopic involvement with SCCL. Patients receiving ABMT had a median age of 48 years, had received a median of 2.5 chemotherapy regimens prior to transplantation, and were transplanted a median of 35.5 months from diagnosis. Among patients receiving ABMT, 5 year actuarial survival was 56+/-11%. Median survival was 126+ months, and median survival from diagnosis was 191 months. Univariate and multivariate analysis identified sensitive disease as the best predictor of a favorable response. Five-year actuarial survival was 66+/-12% for patients with sensitive disease at the time of transplant as compared to 29+/-17% for patients with resistant disease, P = 0.015. Median survival in patients with sensitive disease at the time of ABMT was 126+ months. By univariate analysis, survival was significantly better for patients receiving ABMT as compared to patients receiving allogeneic transplants. Median survival following allogeneic transplantation was 5 months; 5 year actuarial survival was 15+/-13%. In a multivariate analysis, which considered autologous vs allogeneic transplantation, sensitive vs resistant disease, <3 vs > or = 3 prior treatments, and prior bone marrow involvement, allogeneic transplantation was significantly associated with poor survival. Treatment-related mortality occurred in eight of 15 patients receiving allogeneic transplantation and limited the effectiveness of this therapy. High-dose therapy in conjunction with ABMT is effective therapy for patients with SCCL whose disease is sensitive to chemotherapy and whose marrows are microscopically free of disease. Because of possible selection bias, it has not been proven that this approach increases survival in these patients. Treatment-related mortality limits the effectiveness of allogeneic transplantation in SCCL.  (+info)

Autologous transplantation of chemotherapy-purged PBSC collections from high-risk leukemia patients: a pilot study. (5/1778)

We have recently demonstrated that the combination of the alkylating agent nitrogen mustard (NM) and etoposide (VP-16) is capable of eliminating, ex vivo, leukemic cells contaminating PBSC collections and this is associated with a significant recovery of primitive and committed hematopoietic progenitor cells. Based on these data a pilot study on autologous transplantation of NM/VP-16 purged PBSC for high-risk leukemic patients was recently initiated. Twelve patients (seven females and five males) with a median age of 46 years (range 18-57) have been treated. Two patients had acute myeloblastic leukemia (AML) resistant to conventional induction treatment, four patients had secondary AML in I complete remission (CR), one patient was in II CR after failing a previous autologous BM transplantation, while two additional AML individuals were in I CR achieved after three or more cycles of induction treatment. Two patients with high-risk acute lymphoblastic leukemia (ALL) in I CR and one patient with mantle cell lymphoma and leukemic dissemination were also included. Eight patients showed karyotypic abnormalities associated with a poor clinical outcome. The mobilizing regimens included cytosine arabinoside and mitoxantrone with (n = 6) or without fludarabine (n = 3) followed by subcutaneous administration of G-CSF (5 microg/kg/day until the completion of PBSC collection) and G-CSF alone (n = 3) (15 microg/kg/day). A median of two aphereses (range 1-3) allowed the collection of 7.2 x 10(8) TNC/kg (range 3.4-11.5), 5 x 10(6) CD34+ cells/kg (range 2.1-15.3) and 9.2 x 10(4) CFU-GM/kg (0.3-236). PBSC were treated with a constant dose of 20 microg of VP-16/ml and a median individual-adjusted dose (survival < or = 5% of steady-state BM CFU-GM) of NM of 0.7 microg/ml (range 0.25-1.25). Eleven patients were reinfused after busulfan (16 mg/kg) and Cy (120 mg/kg) conditioning with a median residual dose of 0.3 x 10(4) CFU-GM/kg (0-11.5). The median time to neutrophil engraftment (>0.5 x 10(9)/l) for evaluable patients was 25 days (range 12-59); the median time to platelet transfusion independence (>20 and >50 x 10(9)/l) was 40 days (18-95) and 69 days (29-235), respectively. Hospital discharge occurred at a median of 25 days (18-58) after stem cell reinfusion. Four individuals are alive in CR (n = 3) or with residual nodal disease (n = 1 lymphoma patient) with a follow-up of 32, 26, 3 and 14 months, respectively. Seven patients died due to disease progression or relapse (n = 5) or extrahematological transplant toxicity (n = 2). Our data suggest that pharmacological purging of leukapheresis collections of leukemic patients at high-risk of relapse is feasible and ex vivo treated cells reconstitute autologous hematopoiesis.  (+info)

Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens. (6/1778)

Allogeneic bone marrow transplantation (BMT) is a common treatment of hematologic malignancies. Recurrence of the underlying malignancy is a major cause of treatment failure. Donor-derived cytotoxic T lymphocytes (CTLs) specific for patients' minor histocompatibility antigens (mHags) play an important role in both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) reactivities. mHags HA-1 and HA-2 induce HLA-A*0201-restricted CTLs in vivo and are exclusively expressed on hematopoietic cells, including leukemic cells and leukemic precursors, but not on fibroblasts, keratinocytes, or liver cells. The chemical nature of the mHags HA-1 and HA-2 is known. We investigated the feasibility of ex vivo generation of mHag HA-1- and HA-2-specific CTLs from unprimed mHag HA-1- and/or HA-2-negative healthy blood donors. HA-1 and HA-2 synthetic peptide-pulsed dendritic cells (DCs) were used as antigen-presenting cells (APC) to stimulate autologous unprimed CD8(+) T cells. The ex vivo-generated HA-1- and HA-2-specific CTLs efficiently lyse leukemic cells derived from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) patients. No lytic reactivity was detected against nonhematopoietic cells. Sufficient numbers of the CTLs can be obtained for the adoptive immunotherapy purposes. In conclusion, we present a feasible, novel therapy for the treatment for relapsed leukemia after BMT with a low risk of GVHD.  (+info)

Treatment of multiple myeloma. (7/1778)

BACKGROUND AND OBJECTIVE: Multiple myeloma (MM) accounts for about 10% of all hematologic malignancies. The standard treatment with intermittent courses of melphalan and prednisone (MP) was introduced more than 30 years ago and, since then there has been little improvement in event-free and overall survival (EFS & OS). The aim of this article is to review: 1) the role of initial chemotherapy (ChT), maintenance treatment with alpha-interferon and salvage ChT, 2) the results of high-dose therapy (HDT) followed by allogeneic or autologous stem cell transplantation (allo-SCT and auto-SCT), and 3) the most important supportive measures. EVIDENCE AND INFORMATION SOURCES: The authors of this review have been actively working and contributing with original investigations on the treatment of MM during the last 15 years. In addition, the most relevant articles and recent abstracts published in journals covered by the Science Citation Index and Medline are also reviewed. STATE OF THE ART AND PERSPECTIVES: The importance of avoiding ChT in asymptomatic patients (smoldering MM) is emphasized. The criteria and patterns of response are reviewed. MP is still the standard initial ChT with a response rate of 50-60% and an OS of 2-3 years. Combination ChT usually increases the response rate but does not significantly influence survival when compared with MP. Exposure to melphalan should be avoided in patients in whom HDT followed by auto-SCT is planned, in order to not preclude the stem cell collection. The median response duration to initial ChT is 18 months. Interferon maintenance usually prolongs response duration but in most studies does not significantly influence survival (a large meta-analysis by the Myeloma Trialists' Collaborative Group in Oxford is being finished). In alkylating-resistant patients, the best rescue regimens are VBAD or VAD. In patients already resistant to VBAD or VAD and in those in whom these treatments are not feasible we recommend a conservative approach with alternate day prednisone and pulse cyclophosphamide. While HDT followed by autotransplantation is not recommended for patients with resistant relapse, patients with primary refractory disease seem to benefit from early myeloablative therapy. Although results from large randomized trials are still pending in order to establish whether early HDT intensification followed by auto-SCT is superior to continuing standard ChT in responding patients, the favorable experience with autotransplantation of the French Myeloma Intergroup supports this approach. However, although the complete response rate is higher with intensive therapy, the median duration of response is relatively short (median, 16 to 36 months), with no survival plateau. There are several ongoing trials comparing conventional ChT with HDT/autoSCT in order to identify the patients who are likely to benefit from one or another approach. With allo-SCT there is a transplant-related mortality ranging from 30 to 50% and also a high relapse rate in patients achieving CR. However, 10 to 20% of patients undergoing allo-SCT are long-term survivors (> 5 years) with no evidence of disease and, consequently, probably cured. The use of allogeneic peripheral blood stem cells (PBSC) in order to speed the engraftment and also the use of partially T-cell depleted PBSC which can decrease the incidence of graft-versus-host disease are promising approaches. In the setting of allo-SCT, donor lymphocyte infusion is an encouraging strategy in order to treat or prevent relapses. Finally, important supportive measures such as the treatment of anemia with erythropoietin, the management of renal failure and the use of bisphosphonates are reviewed.  (+info)

Costs of high-dose salvage therapy and blood stem cell transplantation for resistant-relapsed malignant lymphomas in a southern Italian hospital. (8/1778)

BACKGROUND AND OBJECTIVE: Analysis of costs of high technological procedures such as peripheral blood stem cell (PBSC) autotransplantation in lymphomas are generally finalized at disclosing whether the improvement of survival in a subset of patients is cost effective and whether the cost of the procedure could be reduced. With the aim of revealing a possibility of reducing costs with respect to conditions of safety, we present our experience with PBSC autotransplantation in a particularly poor prognosis subset of patients with lymphoma. DESIGN AND METHODS: The expenses are analyzed for groups of cost and main resources necessary at unitary cost are considered separately. Groups of cost include various phases of the PBSC autotransplantation such as preparative procedures, execution of myeloablative therapy, reinfusion of CD34 cells, supportive therapy after reinfusion until discharge of the patient, general support for the management of patient. All costs are calculated according to 1997 prices and salaries and reported in dollars. The analysis was conducted on 21 patients with lymphoma resistant to other therapies treated by myeloablative therapy and PBSC autotransplantation in an hematologic unit in an open ward; the assistance was provided by staff not exclusively dedicated to bone marrow transplant procedures, with some help from a family member. RESULTS: The PBSC procedure, including all phases, costs from $17,761.9 to $18,259.9 depending on the type of myeloablative therapy employed; the mean cost was $18,092.6. The preparative phase with mobilization of CD34 cells, cryopreservation and reinfusion costed $3,538.7 (19.6% of the total cost); a major cost of this phase was cryopreservation and CD34 manipulation ($857.1). The second phase with myeloablative therapy and reinfusion of CD34 cells had a mean cost of $2,785.9 (15.4% of the total cost); a major cost of this phase was the hospitalization ($1,119.8). The third phase of patient's support after treatment had a total cost of $7,649 (42.3% of the cost of the total procedure) with the major cost being due to hospitalization ($2,571) calculated on a mean of 15 days after the reinfusion of CD-34. The last group of costs, including management support, accounted for $4,119 (22.7%) with a major cost being amortization of the structure ($1,600). The general cost for nurse's assistance to the patient was $1,355.1 (7.5%). INTERPRETATION AND CONCLUSIONS: A procedure of PBSC autotransplantation in resistant lymphoma is affordable without the strict precautions generally given in intensive care units. This provides a substantial reduction of expenses because of the low number of specifically trained staff members and the generally low cost of the necessary supplies. Before, however, proposing PBSC autotransplantation in most patients with resistant lymphoma, an evaluation of whether costs could be further reduced and whether the procedure has a cost benefit impact is needed.  (+info)

Key clinical point: Second allogeneic transplant is an effective salvage therapy option after relapse in children with lymphoid cancers or myelodysplastic diseases.Major finding: 3-year overall survival was 26% for children who had a second transplant vs. 4% for those who did not.Study details: Retrospective study of 221 patients aged 21 years and younger who had a relapse after stem cell transplant for ALL, AML, or MDS.
The promise of a better response to salvage therapy on the one hand may be offset by the risk of increased immune suppression on the other. Such situations of equipoise call for randomized, prospective clinical trials. Three have been completed, and the results of the largest are reported by Lawrence et al. in this issue of the New England Journal of Medicine (pages 837-846). Patients with multidrug-resistant HIV and HIV RNA levels of more than 5000 copies per milliliter either started a salvage regimen immediately (the control group) or stopped antiretroviral treatment for four months before starting the salvage regimen (the treatment-interruption group). Recruitment was stopped prematurely because the treatment-interruption group did worse than the control group: 22 cases of disease progression or death, as compared with 12 cases. Unexpectedly, most end points occurred after the interruption of treatment. There was no evidence of a favorable effect on surrogate markers. As expected, CD4 cell ...
144 Studies found for: treatment experienced OR treatment failure OR second line OR resistance OR salvage therapy , Recruiting, Not yet recruiting, Available Studies , HIV ...
See the list below: Salvage therapy may be needed for recurrent or persistent disease after the use of chemoradiotherapy. Local recurrences may be successfully salvaged with surgery; however, locall... more
By Andreas Tsavliris, President of the International Salvage Union. The legal framework which governs salvage is complicated and has evolved over the centuries. At the heart of that framework lies the 1989 Salvage Convention (the Convention). But the International Salvage Union, (ISU), which represents the interests of the global salvage industry, believes that some Articles in the Convention are outdated and no longer fit for purpose. In particular ISU considers the Convention should be modified to continue providing for the assessment of a financial Award for salvage services to maritime property, and, crucially, should also provide a financial Award for the degree of success a salvor achieves in preventing or minimising damage to the environment during salvage services.. The present system under the Convention, and the commercial arrangements of the most commonly-used salvage contract, Lloyds Form 2011 (and where applicable the Special Compensation P&I Club Clause - SCOPIC 2011) are not ...
The results show that frequencies were as follows: cumulative NRM at 3 years, 14%; acute and chronic graft-versus-host disease (GVHD) 35 and 52%, respectively; 3-year overall survival (OS), 69% for LG-NHL, 69% for HG-NHL, 45% for MCL and 32% for HD (P=0.058); and 3-year relapse incidence, 29, 31, 35 and 81%, respectively (P,0.001). Relapse risk differed significantly at 3 years between follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) (14 versus 46%, P=0.04). Molecular remission occurred in 94 and 40% (P=0.002) of patients with FL and CLL, respectively. On multivariate analysis, OS was influenced by chemorefractory disease (hazard ratio (HR)=3.6), diagnosis of HD (HR=3.5), and acute GVHD (HR=5.9). RIC allogeneic SCT is a feasible and effective salvage strategy in both indolent and aggressive NHL. ...
Définitions de Nucleotide salvage, synonymes, antonymes, dérivés de Nucleotide salvage, dictionnaire analogique de Nucleotide salvage (anglais)
Vol. 43 (x): 2017 November 11. doi: 10.1590/S1677-5538.IBJU.2017.0025 ORIGINAL ARTICLE Shawn Dason 1, Nathan C. Wong 1, Christopher B. Allard 1,
The HIV-NAT 013 study (conducted in 2003) evaluated prevalence and pattern of RT mutation in 95 children treated with dual NRTI. The study showed almost all children to have some degree of NRTI resistance and 40% with multi NRTI resistance. The mutation reported was major mutation.. After the study, the patients were managed based on the physicians judgment using genotyping results. The 95 patients in HIV-NAT 013 are categorized into 3 groups.. ...
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But Trottier suggested that retaining lamivudine in the presence of M184V after a salvage regimen controls HIV may make less sense. The Montreal investigators observed that continuing largely inactive NRTIs may add toxicity, unwanted drug interactions, and cost. Furthermore, antiretroviral guidelines offer no advice on keeping inactive NRTIs in a rescue regimen. Therefore, they planned this single-arm, open-label trial to test the hypothesis that dropping such drugs from a salvage regimen would not compromise virologic response or cause clinical problems ...
AFM13 is a first-in-class product for CD30 positive tumors. It will initially be developed in the high medical need salvage setting of Hodgkin Lymphoma
As part of my work as an HIV cure and salvage treatment activist, I am constantly searching for treatment options that could ... help patients with ...
Salvage cover definition is - a waterproof sheet for protecting goods from damage by water, smoke, or weather during or after a fire.
A salvage pathway is a pathway in which nucleotides (purine and pyrimidine) are synthesized from intermediates in the degradative pathway for nucleotides. Salvage pathways are used to recover bases and nucleosides that are formed during…
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A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
TY - JOUR. T1 - Evaluation of MDM2, p16, and p53 staining levels as biomarkers of biochemical recurrence following salvage radiation therapy for recurrent prostate cancer. AU - Heckman, Michael G.. AU - Parker, Alexander S.. AU - Wu, Kevin J.. AU - Hilton, Tracy W.. AU - Ko, Stephen J.. AU - Pisansky, Thomas M.. AU - Schild, Steven E.. AU - Khor, Li Yan. AU - Hammond, Elizabeth H.. AU - Pollack, Alan. AU - Buskirk, Steven J.. PY - 2012/12/1. Y1 - 2012/12/1. N2 - Background. AND PURPOSE The selection of appropriate candidates for salvage radiation therapy (SRT) to address a rising PSA following radical prostatectomy remains challenging. Herein, we provide the first evaluation of the ability of staining levels of the tumor based biomarkers MDM2, p16, and p53 to aid in prediction of biochemical recurrence (BCR) among men undergoing SRT for recurrent prostate cancer. Material And Methods. We identified 152 patients who were treated with SRT between July 1987 and July 2003. Staining levels of MDM2, ...
TY - JOUR. T1 - A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomy. AU - Armstrong, A. J.. AU - Halabi, S.. AU - Healy, P.. AU - Lee, W. R.. AU - Koontz, B. F.. AU - Moul, J. W.. AU - Mundy, K.. AU - Creel, P.. AU - Wood, S.. AU - Davis, K.. AU - Carducci, M. A.. AU - Stein, M.. AU - Hobbs, C.. AU - Reimer, B.. AU - Nguyen, M.. AU - Anand, M.. AU - Bratt, L.. AU - Kim, S.. AU - Tran, P. T.. AU - George, D. J.. N1 - Funding Information: This work has received research support from Pfizer and Sanofi (AJA, DJG), consulting with Pfizer and Sanofi (AJA, DJG, MAC), speakers bureau for Sanofi (DJG). The remaining authors declare no conflict of interest. Funding Information: We thank the DOD PCCTC for their infrastructural support for this trial, and to Avery Spitz RN for her dedication and coordination at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and to the ...
article: Salvage radiation therapy after radical prostatectomy: survival analysis - Minerva Urologica e Nefrologica 2019 June;71(3):240-8 - Minerva Medica - Riviste
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The options available for patients with recurrent prostate cancer are limited. Men who have failed external-beam irradiation as the primary treatment are rarely considered for potentially curative salvage therapy. Traditionally, only palliative treatments have been offered with hormonal intervention or simple observation. A significant percentage of these patients have only locally recurrent cancer and are thus candidates for curative salvage therapy. Permanent brachytherapy with iodine-125 or palladium-103 has been used in an attempt to eradicate the remaining prostate cancer and prevent the need for additional intervention. It is critical in this population to identify patients most likely to have distant metastases or who are unlikely to suffer death or morbidity from their recurrence, in order to avoid potential treatment morbidity in those unlikely to benefit from any intervention. Following salvage brachytherapy, up to 98% of these cancers may be locally controlled, and 5-year freedom from second
This study investigated the toxicity and efficacy of nivolumab as a single agent in the treatment of relapsed or refractory Hodgkins lymphoma (HL) after
Viagra mountain city - The patient-ventilator system warrants careful monitoring. Contains at least two enzymatic blocks have been associated with other heart problems. Currant jelly stool late finding skeletal changes including gibbus, neurologic regression, and intermittent long-term use of effective salvage therapy with high-dose chemotherapy and local mediators of in-flammation.
Consistent Outcomes Using Ryoncil™ as First-Line Treatment or Salvage Therapy in 309 Children With Steroid-Refractory Acute GVHD - read this article along with other careers information, tips and advice on BioSpace
Those randomized to the control arm received a preselected salvage chemotherapy regimen. The choices included mitoxantrone/etoposide/cytarabine (MEC), fludarabine/cytarabine/granulocyte colony-stimulating factor/idarubicin (FLAG-IDA), low-dose cytarabine, or azacitidine. The dose of gilteritinib was 120 mg/d, although dose escalation to 200 mg was possible. The primary endpoints of the trial were overall survival and percentage of patients who had complete remission with full or partial hematologic recovery.. Survival, Transplantation Eligibility, and Response. A total of 625 patients were screened to find the 371 eligible patients who underwent randomization. Overall, 61% of the patients had relapsed AML, and the others had primary refractory disease. Of note, just 6% had received midostaurin during induction therapy. In the control arm, well over half of the patients received one of the two high-intensity therapies (MEC or FLAG-IDA). The primary endpoint of the trial was met: patients ...
Summary of eligibility criteria, additional details may apply Inclusion Criteria: - Aged 18 years or older. - Participants with B-ALL with Relapsed or Refractory disease after at least 2 cycles of chemotherapy. - Relapsed or Refractory at any time after first salvage therapy or refractory relapse. - Relapse at any time after hematopoietic stem cell transplant (HSCT). - Greater than 5% blasts in the bone marrow. - Eastern Cooperative Oncology Group (ECOG) Performance Status less than or equal to 2. - Participants with relapse or refractory B Cell ALL Ph+ disease and that are intolerant or refractory to prior tyrosine kinase inhibitors (TKIs) are eligible. - Negative pregnancy test in women of childbearing potential. Exclusion Criteria: - Active ALL in the central nervous system (CNS). Presence of greater than 5 white blood cells per cubic millimeter in cerebrospinal fluid (CSF) with lymphoblasts present and or clinical signs of CNS leukemia. - History or presence of clinically relevant CNS ...
Patients received salvage chemotherapy with 2 cycles of CEPP (cyclophosphamide 600 mg/m2 intravenously [IV] days 1 and 8; etoposide 70 mg/m2 IV day 1, 140 mg/m2 by mouth [PO] days 2 and 3; procarbazine and prednisone 60 mg/m2 PO days 1 through 10). Patients with clear clinical or radiographic evidence of progression during salvage therapy were to be removed from the study. Protocol treatment began a minimum of 4 weeks after the last dose of salvage therapy (Figure1, schema). Patients randomized to arm A received G-CSF at 10 μg/kg per day subcutaneously (SC) for 4 days, following which PBCs were collected. High-dose cyclophosphamide was then administered, no earlier than 1 day and no later than 7 days after complete PBC collection, at 5 g/m2 (2.5 g/m2 IV over 1 hour at a 3-hour interval for 2 doses). Patients randomized to arm B received the same dose of cyclophosphamide (5 g/m2), followed by G-CSF at 10 μg/kg per day SC starting 24 hours later; PBCs were collected on hematologic recovery. ...
This study is being done to test the safety and effectiveness of pembrolizumab followed by radiation therapy in Hodgkin lymphoma. The purpose of this study is
This is a phase II, open-label trial of Gefitinib and docetaxel in patients having one prior regimen of chemotherapy for with metastatic pancreatic carc
Antiretroviral therapy (ART) sometimes needs to be changed if the treatment is not working. This usually happens when the HIV viral load (see Fact Sheet ...
MINI DEXA BEAM JAKO DRUH ZÁCHRANN REÎIM U NEMOCN CH S LYMFOMY PO SELHÁNÍ PRVNÍ, NA IFOSFAMIDU A ETOPOSIDU ZALOÎENÉ CHEMOTERAPII MINI DEXA BEAM AS THE SECOND SALVAGE REGIMEN IN LYMPHOMA PATIENTS, ADMINISTERED
Salvage surgery is associated with prolonged survival in patients with rectal cancer who have lung and liver recurrence after TME.
A clinical study of safety and efficacy of treatment with Nivolumab and DHAP in patients with relapsed/refractory Hodgkins lymphoma
The PORTEC-1 trial has demonstrated that postoperative external beam radiotherapy for stage 1 endometrial cancer significantly increases local control (from 85 to 96%), but has no impact on survival. Salvage therapy for isolated vaginal recurrence, the main site of recurrence in the control group, was effective with a complete remission rate of 89% and actuarial 5-year survival of 65% in the control group. The use of postoperative RT should therefore be limited to the group of patients at sufficiently high risk of locoregional recurrence (15% or over) to warrant the risk of treatment associated morbidity in order to maximize initial local control and relapse-free survival ...
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I have a patient with advanced immunosuppression (CD4 40, HIV RNA = 276,000) who requires a salvage regimen, having failed on multiple treatments in the past.
Well a 42% rate of treatment failure is not good. However, it is important to note that this study included a mixed bag of patients: those on first line therapy, salvage treatment, deep salvage; on...
The Navajo-class towing, salvage and rescue ships (T-ATS) are being constructed for the US Navy. The lead ship of the class is named Navajo.
So many questions re Salvage Radiation Hi melanie Here are my answers How old were you when you were first diagnosed with PCa? 44 -what was your post-RP Gleason score? 3+4 --What was your uPSA when you decided to have SRT? i.e., what was.... ...
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Ive talked on Troppo a few times on the joys of theming. Instead of organising the stimulus around a pragmatic search for all the possible ways we could expand the budget implementing all the most prospective in terms of economic expansion per dollar spent down to some level at which we stopped, we decided that it had to be themed. The theme was Building the Education Revolution, and greening our household roofs with pink batts. We had our hard hats on and choosing the theme bore some resemblance to working out the theme for a ball.. Of course one can understand that there are communications imperatives. So youd try to meet them at minimum cost. It would be easy to design the stimulus, look at whats in it and theme it then - and perhaps work a little way in the other direction - the bureaucrats taking note of the governments themes and trying to look a little harder in those areas. But the further you go down that latter path, the more youre degrading what youre doing with PR ...
TY - JOUR. T1 - Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma. AU - Sauter, Craig S.. AU - Matasar, Matthew J.. AU - Meikle, Jessica. AU - Schoder, Heiko. AU - Ulaner, Gary A.. AU - Migliacci, Jocelyn C.. AU - Hilden, Patrick. AU - Devlin, Sean M.. AU - Zelenetz, Andrew D.. AU - Moskowitz, Craig. PY - 2015/4/16. Y1 - 2015/4/16. N2 - High-dose chemotherapy (HDT) plus autologous stem cell transplantation (ASCT) is the standard of care for chemosensitive relapsed and refractory diffuse large B-cell lymphoma (rel/ref DLBCL). Interim restaging with functional imaging by positron emission tomography using 18F-deoxyglucose (FDG-PET) has not been established after salvage chemotherapy (ST) and before HDT-ASCT by modern criteria. Herein, we evaluated 129 patients with rel/ref DLBCL proceeding to HDT-ASCT, with ST response assessment by FDG-PET according to the contemporary Deauville 5-point scale. At 3 years, patients ...
NICE has published final guidance which recommends tisagenlecleucel (Kymriah) therapy for use within the Cancer Drugs Fund as an option for treating relapsed or refractory diffuse large B-cell lymphoma in adults after two or more systemic therapies, only if the conditions in the managed access agreement are followed. There is no standard treatment for relapsed or refractory diffuse large B-cell lymphoma after two or more systemic therapies. Salvage chemotherapy (that is, chemotherapy to control the disease) is the most common treatment option. Evidence from a single-arm study with short follow-up and a small observational study suggests that people having tisagenlecleucel may live for longer or have more time before their disease relapses. But longer follow-up from the study is needed and there are no data directly comparing tisagenlecleucel with salvage chemotherapy. To assess the comparative effectiveness of tisagenlecleucel and salvage chemotherapy, data from the first CORAL extension study ...
Methods: We reviewed 76 patients with pT2-3N0M0 prostate cancer who underwent salvage radiotherapy for post-prostatectomy biochemical recurrence at the following three timings: ultra-early salvage radiotherapy (n = 20) delivered before meeting a current definition of biochemical recurrence (two consecutive prostate-specific antigen [PSA] values ≥0.2 ng/mL); early salvage radiotherapy (n = 40) delivered after meeting the definition but before PSA reached 0.5 ng/mL; and delayed salvage radiotherapy (n = 16) delivered after PSA reached 0.5 ng/mL. The primary endpoint was failure of salvage radiotherapy, defined as a PSA value ≥0.2 ng/mL. The log-rank test and Cox proportional hazards model were used for univariate and multivariate analyses, respectively ...
Refractory Diffuse Large B-Cell Lymphoma - immune signatures of CRS and neurologic events in subjects treated with KTE-C19 in the ZUMA-1 trial: presentation at the AACR 2017 annual meeting
OncologyPRO is the home of ESMOs educational & scientific resources, with exclusive content for ESMO members such as ESMOs Congresses webcasts,
The purpose of this clinical guideline on Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline is to provide a clinical framework for the use of radiotherapy after prostatectomy in patients with and without evidence of prostate cancer recurrence.
Background: Mortality due to severe LD remains high with 20-25% of patients requiring mechanical ventilation. TG, a minocycline derivative, is active against L. pneumophila in animal and cell models, achieves high concentrations intracellularly and demonstrated minimal in vitrosynergy with levofloxacin (LVX). Clinical data on TG for LD are limited to two case reports in immunocompromised hosts. We describe our experience with TG as salvage therapy in severely ill patients with LD. Methods: Patient demographics, clinical data and treatment details were collected retrospectively. Clinical failure was defined based on vital signs (temperature ≥37.2 C, heart rate ≥100 beats/min, respiratory rate ≥24 breath/min, systolic ≤100 mm Hg, oxygen saturation on room air ,90%) and/or physician-documented deterioration in clinical parameters or death. Results: At our University Medical Center 12 patients with severe LD (positive Legionella urinary antigen n=8, elevated L. pneumophiliaantibody n=4) ...
Broun, E. R., Nichols, C. R., Turns, N. és mtsai: Early salvage therapy for germ cell cancer using high dose chemotherapy with autolous bone marrow support. Cancer, 1994, 73 , 1716-1720.. Turns N. , Early salvage therapy for germ cell cancer using high dose chemotherapy with autolous bone marrow support (1994 ) 73 Cancer : 1716 -1720.. ...
t(8;21)(q22;q22): a study of the German-Austrian AML Study Group. Leukemia 2017;31:1012-15. Schlenk RF, Frech P, Weber D, Brossart P, Horst HA, Kraemer D, Held G, Ringhoffer M, Burchardt A, Kobbe G, Götze K, Nachbaur D, Fischer T, Lübbert M, Salih HR, Salwender H, Wulf G, Koller E, Wattad M, Fiedler W, Kremers S, Kirchen H, Hertenstein B, Paschka P, Gaidzik VI, Teleanu V, Heuser M, Thol F, Döhner K, Krauter J, Ganser A, Döhner H; and for the German-Austrian AMLSG. Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia. Leukemia 2017;31:1217-20. Wattad M, Weber D, Döhner K, Krauter J, Gaidzik VI, Paschka P, Heuser M, Thol F, Kindler T, Lübbert M, Salih HR, Kündgen A, Horst HA, Brossart P, Götze K, Nachbaur D, Köhne CH, Ringhoffer M, Wulf G, Held G, Salwender H, Benner A, Ganser A, Döhner H, Schlenk RF. Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure. Leukemia ...
Loncastuximab tesirine appeared effective and safe for patients with relapsed or refractory diffuse large B-cell lymphoma, according to topline data released by the agent’s manufacturer.Loncastuximab tesirine (ADCT-402, ADC Therapeutics) is an antibody-drug conjugate composed of a humanized monoclonal antibody directed against CD19 and conjugated to a pyrrolobenzodiazepine dimer cytotoxin.
I realize that the side effects of radiation often take a while to show themselves, but Im wondering if anyones dealt with post radiation incontinence issues and can share any expierences there. My Oncologist is referring back to my Uro. My post RP leaking cleared up in stages and took about 10 weeks to resolve. Just wondering if there is a progression/resoloution curve here as well ...
Wrong thread. Update about it here instead: https://www.tinnitustalk.com/threads/the-love-hormone-may-quiet-tinnitus.17618/ Im sorry your post has...
Médecins Sans Frontières has released the 18th edition of its HIV drug pricing report, Untangling the Web of Antiretroviral Price Reductions, at the International AIDS Conference in Durban, South Africa today.
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Colleges across the country are struggling to salvage the fall semester amid skyrocketing coronavirus cases, entire dorm complexes and frat houses under quarantine, and flaring tensions with local community leaders over the spread of the disease.
Legislation that originally repealed the six-year limitation for applying a salvage brand to a motor vehicle for which the cost of being repaired exceeded its value was signed into law by Governor John Hickenlooper.
Find tickets for Doom Flamingo showing at the Salvage Station - Outdoor Stage - Asheville, US Sunday Nov 8, 6:00PM Tickets starting at $40.00
Pakistan ordered fresh evacuations from Sindh province on Thursday as the country struggled to bring relief to millions already displaced by flooding and sought international help to rescue its economy.
Gareth Bale scored twice to save Real Madrid from a damaging defeat away at Villarreal on Sunday before capping a dramatic 2-2 draw by being sent off in injury-time.
Jenkins NL, Lalikos JF, Wooden WA, Benacci JC, Meadows WM. Innovative techniques in bony reconstruction to facilitate hand salvage. Ann Plast Surg. 2002 May; 48(5):484-8 ...
Do you have small bits of paper you cant bear to throw away, but dont know what to do with them? Do you salvage jars from pickles and pimientos? This project MAY be the solutions for both things! Check out this tutorial at Design Sponge. … [Read more...] ...
Wedemeyer, Christian; Kauther, Max Daniel (2011-03-16). "Hemipelvectomy- only a salvage therapy?". Orthopedic Reviews. 3 (1): ...
salvage therapy (rescue therapy) A therapy tried after others have failed; it may be a "last-line" therapy. ... First-line therapy (sometimes called induction therapy, primary therapy, or front-line therapy)[2] is the first therapy that ... palliative therapy See supportive therapy for connotative distinctions. preventive therapy. (prophylactic therapy) A therapy ... manual therapy as massotherapy and therapy by exercise as in physiotherapy and exercise therapy *inversion therapy ...
salvage therapy (rescue therapy) A therapy tried after others have failed; it may be a "last-line" therapy. ... First-line therapy (sometimes called induction therapy, primary therapy, or front-line therapy)[2] is the first therapy that ... palliative therapy See supportive therapy for connotative distinctions. preventive therapy. (prophylactic therapy) A therapy ... by physical therapy/occupational therapy, vision therapy, massage therapy, chiropractic or acupuncture ...
Fuzeon (enfuvirtide), for salvage therapy of HIV-1 infection. Gazyva (obinutuzumab), for chronic lymphocytic leukemia. Hemlibra ... A second gene therapy-related action came in December with the US$1.15 billion acquisition of non-United States rights to an ... In 1995 the era of highly active anti-retroviral therapy (HAART) was initiated by the United States FDA's approval of Hoffman ... "Roche 'steps up' for gene therapy with $4.3 billion Spark bet". Reuters. 25 February 2019 - via uk.reuters.com. "Roche says its ...
It is not considered a first-line treatment, but it can be useful as salvage therapy. It also has the advantage of being less ... Chan JK, Loizzi V, Manetta A, Berman ML (2004). "Oral altretamine used as salvage therapy in recurrent ovarian cancer". Gynecol ... Malik IA (2001). "Altretamine is an effective palliative therapy of patients with recurrent epithelial ovarian cancer". Jpn. J ... a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy ...
When primary or secondary resistance invariably develops, salvage therapy is considered. Allogeneic stem cell transplantation ... They recommended starting therapy in patients with constitutional symptoms such as recurrent fever, night sweats, fatigue due ... Gertz MA (2005). "Waldenstrom macroglobulinemia: a review of therapy". Am J Hematol. 79 (2): 147-57. doi:10.1002/ajh.20363. ... Burwick, N.; Roccaro, A.; Leleu, X.; Ghobrial, I. (2008). "Targeted therapies in Waldenström macroglobulinemia". Current ...
August 2001). "Mito-flag as salvage therapy for relapsed and refractory acute myeloid leukemia". Onkologie. 24 (4): 356-60. doi ...
Summerfield DT, Desai H, Levitov A, Grooms DA, Marik PE (2011). "Inhaled Nitric Oxide as Salvage Therapy in Massive ... Nitric oxide is also administered as salvage therapy in patients with acute right ventricular failure secondary to pulmonary ... It is used on an individualized basis in ICUs as an adjunct to other definitive therapies for reversible causes of hypoxemic ... This research is based on the fact that nitric oxide was investigated as an experimental therapy for SARS. Brian Strickland, MD ...
other antibiotics, such as minocycline, have seen some use as a salvage therapy). If infected during pregnancy, spiramycin is ... Combination therapy is most useful in the setting of HIV. Clindamycin Spiramycin - an antibiotic used most often for pregnant ... As a result, the diagnosis is made by a trial of therapy (pyrimethamine, sulfadiazine, and folinic acid (USAN: leucovorin)), if ... an antibiotic used in combination with pyrimethamine to treat toxoplasmosis Combination therapy is usually given with folic ...
Per Montag's request to salvage their relationship, Pratt agreed to attend couples' therapy. As they became re-engaged and ...
Voriconazole is also being studied in salvage therapy for refractory cases. A case report indicated that voriconazole in ... Posaconazole has been approved by the European Commission as a salvage therapy for refractory coccidioidomycosis. Clinical ... Duration of therapy and costs[edit]. The objectives of treatment are resolution of infection, decrease of antibody titers, ... The duration of therapy is dictated by the clinical course of the illness, but it should be at least 6 months in all patients ...
The treatments include surgery, chemotherapy, radiation therapy, targeted therapy, salvage therapy, and clinical trials. Among ... Salvage Therapy: this treatment is given if there is no response to previous treatments. Clinical Trials: the follow up study ... February 2014). "Salvage therapy for refractory or recurrent pediatric germ cell tumors: the French SFCE experience". Pediatric ... "Radiation Therapy". National Cancer Institute. 2015-04-29. Retrieved 2019-05-27. "Understanding Targeted Therapy". Cancer.Net. ...
"Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases". Clin Infect Dis. 42 (7): e61 ... analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent ...
Intraoperative radiation therapy and Intraoperative blood salvage may also be performed during this time. The postoperative ...
2006). "Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance". Antivir. Ther. (Lond ... Foscarnet can be used to treat highly treatment-experienced patients with HIV as part of salvage therapy. Foscarnet is a ... 2007). "Long-term foscarnet therapy remodels thymidine analogue mutations and alters resistance to zidovudine and lamivudine in ...
"Refractory Craniofacial Actinomycetoma Due to Streptomyces somaliensis That Required Salvage Therapy with Amikacin and Imipenem ...
"Clarithromycin-Minocycline Combination as Salvage Therapy for Toxoplasmosis in Patients Infected with Human Immunodeficiency ... Occasionally, minocycline therapy may result in autoimmune disorders such as drug-related lupus and autoimmune hepatitis, which ... Autoimmune problems emerge during chronic therapy, but can sometimes occur after only short courses of a couple of weeks of ... Drug reaction with eosinophilia and systemic symptoms syndrome can occur during the first few weeks of therapy with minocycline ...
Small studies have also examined its use as salvage therapy for non-tuberculous mycobacterial infections. It is a component of ... BPaMZ @ TB Alliance Archived 2017-02-19 at the Wayback Machine Two new drug therapies might cure every form of tuberculosis. ...
These include: Visual Representations: Past and Present Artist-At-Work Artist Talk Salvage Art Therapy Exhibition. Power Show ...
"Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in ...
Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone (DHAP). ...
... may delay cell death and allow for greater salvage of myocardium through reperfusion therapy. AICAR has been shown to ... It found a flood of new substances or methods used to enhance blood oxygen capacity include Aicar, Xenon gas, ozone therapy, ... the switch from EPO to blood transfusions or to ozone therapy, or even towards the so-called "oxygen in a pill" in the form of ...
"Salvage therapy with everolimus improves quality of life in patients with refractory chronic graft-versus-host disease" (PDF). ... Interim phase III trial results in 2011 showed that adding Afinitor (everolimus) to exemestane therapy against advanced breast ... and mTOR inhibition has been suggested as an anti-aging therapy. Everolimus was used in a clinical trial by Novartis, and short ... Much research has also been conducted on everolimus and other mTOR inhibitors as targeted therapy for use in a number of ...
testicular cancer, germ cell tumors in salvage therapy EE-4A vincristine, actinomycin[8]. Wilms' tumor[8]. ... Mayer, RJ, Targeted therapy for advanced colorectal cancer -- more is not always better, N Engl J Med. 2009;360:623 which is a ...
Like lopinavir and atazanavir, it is very potent and is effective in salvage therapy for patients with drug resistance. However ... It is administered with ritonavir in combination therapy to treat HIV infection. Tipranavir has the ability to inhibit the ...
They are also useful in salvage therapy for patients whose virus has mutated and acquired resistance to other drugs. ... "raltegravir plus optimized background therapy provided better viral suppression than optimized background therapy alone for at ... A fixed combination therapy of dolutegravir with the NRTIs abacavir and lamivudine is available under the brand name Triumeq, a ... Dolutegravir is marketed as 50 mg tablets as a once or twice daily in a combination ART therapy together with two NRTIs. One ...
Caspofungin is used in the treatment of febrile neutropenia and as "salvage" therapy for the treatment of invasive ...
A local resident salvaged materials from a discarded radiation therapy machine containing 6,010 pellets of 60Co. The transport ... 1985 to 1987 - The Therac-25 was a radiation therapy machine produced by Atomic Energy of Canada Limited (AECL). It is known to ... September, 1996 - San José, Costa Rica: A cobalt radiation therapy device was not properly tuned and 116 patients that were ... September 13, 1987 - In the Goiânia accident, scavengers broke open a radiation-therapy machine in an abandoned clinic in ...
It is used in select situations, for instance as a salvage therapy in severe complicated cases or in other situations. One ... Kim C, Catanzariti AR, Mendicino RW (April 2009). "Tibiotalocalcaneal arthrodesis for salvage of severe ankle degeneration". ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
safe sex - safer sex - salmonella - salvage therapy - SAMHSA - sarcoma - seborrheic dermatitis - secondary prophylaxis - sepsis ... GAG - gamma globulin - gamma interferon - ganglion - GART - gastrointestinal (GI) - gene - gene therapy - genetic engineering ... MAC - macrophage - macrophage-tropic virus - magnetic resonance imaging (MRI) - MAI - maintenance therapy - major ... complementary and alternative therapy - complete blood count (CBC) - computed tomography scan (C-T scan) - concomitant drugs - ...
This salvage process delays onset of deficiency.[107] Ascorbic acid also converts (reversibly) to dehydroascorbate (DHA) and ... Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". Annual Review of ... Under the rubric of orthomolecular medicine, "Intravenous vitamin C is a contentious adjunctive cancer therapy, widely used in ... thereby reducing the adverse effects of chemotherapy and radiation therapy.[40][41] Research continues in this field, but a ...
... engineering aglycosylated full-length IgG antibodies for human therapy". Current Opinion in Biotechnology. 22 (6): 858-67. doi: ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Active surveillance, surgery, radiation therapy, hormone therapy, chemotherapy[2]. Prognosis. 5-year survival rate 99% (US)[4] ... Mouraviev V, Evans B, Polascik TJ (2006). "Salvage prostate cryoablation after primary interstitial brachytherapy failure: a ... Androgen ablation therapy causes remission in 80-90% of patients undergoing therapy, resulting in a median progression-free ... There are exceptions: radiation therapy may be used for some advanced tumors, and hormonal therapy is used for some early stage ...
2 level remains equal to or even below the threshold for continuous oxygen therapy for patients with chronic obstructive ...
Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for ... Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and ... Cytotoxics and targeted therapies[edit]. Targeted therapies are a relatively new class of cancer drugs that can overcome many ... Hyperthermia therapy[edit]. Hyperthermia therapy is heat treatment for cancer that can be a powerful tool when used in ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
In respiratory distress syndrome or RDS surfactant replacement therapy helps patients have normal respiration by using ...
Demand valve oxygen therapy. *Diving chamber. *Diving medicine. *Hyperbaric medicine. *Hyperbaric treatment schedules ...
Therapies that alter pH principally alter the pH of urine, to discourage a possible complication of uricosuric therapy: ... Nucleotide salvage. *Lesch-Nyhan syndrome/Hyperuricemia. *Adenine phosphoribosyltransferase deficiency. Catabolism. *Adenosine ... "Arthritis Research & Therapy. 8 Suppl 1 (Suppl 1): S1. doi:10.1186/ar1906. PMC 3226106. PMID 16820040.. ...
Demand valve oxygen therapy. *First Aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
John Bannister, Area Salvage Team Overman, North Derbyshire Area, National Coal Board. George Albert Barlow, Locomotive Master ... For services to speech therapy. Lewis Arthur Turrell. For services to Highland pipe bands. Samuel Malcolm Wallace, JP. For ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
A C-SALVAGE Phase 2 trial on safety and efficacy was reported in 2015. One randomized, open-label study was done on patients ... Patients had HCV GT1, GT4, or GT6 and were on opioid therapy. Upwards of 96% of the patients achieved SVR24. This study ... Zepatier is one of a few non-interferon therapies that are market-available. Competing treatments include Gilead's Harvoni ( ... Final 24-Week Results From C-SALVAGE". Clinical Infectious Diseases. 62 (32-6). doi:10.1093/cid/civ722. PMID 26371152. CS1 ...
Plasmapheresis is a medical therapy that involves blood plasma extraction, treatment, and reintegration. ...
This has led to some increased interest in autotransfusion, whereby a patient's blood is salvaged during surgery for continuous ... "Indications for Platelet Transfusion Therapy". Southeastern Community Blood Center. Archived from the original on 2008-05-12. ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Sauve AA «NAD+ and vitamin B3: from metabolism to therapies». The Journal of pharmacology and experimental therapeutics, 324, 3 ... Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels». J. Biol. Chem., 277, 21 ...
", "A review of significant salvage operations conducted by U.S. Navy salvage forces and other salvage activities during 1969 ... For flexibility, it was outfitted for many types of oceanographic and salvage missions. In September 1964, Time magazine ... Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Where practicable, lifeboats will usually perform minor salvage and towing operations to assist mariners in distress and ... Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
"NAD+ and vitamin B3: from metabolism to therapies". The Journal of pharmacology and experimental therapeutics 324 (3): 883-93 ... "Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels". J. Biol. Chem. 277 (21 ...
The college collected $8,000 from insurance and salvaged $4,000 worth of stone and brick from the old building. The new ... Pre-professional programs are available in occupational and physical therapy, dentistry, medicine, optometry, pharmacy, and ... and Occupational Therapy club. Partnering with the Blessing-Rieman College of Nursing, Culver-Stockton combines staff and ... and Occupational Therapy (Psychology), International Studies, Public Policy for Political Science majors and Legal Studies. ...
Demand valve oxygen therapy. *First aid. *Hyperbaric medicine. *Hyperbaric treatment schedules. *In-water recompression ...
Salvage therapy, also known as rescue therapy, is a form of therapy given after an ailment does not respond to standard therapy ... Salvage therapy drugs or drug combinations have, in general, much more severe side effects than the standard line of therapy. ... the subsequent attempts to treat the HIV infection may be referred to as salvage therapy. Salvage chemotherapy is a treatment ... Salvage therapy, in this context, is the attempt to contain the replicating HIV once the usual line of treatments have been ...
Local recurrences may be successfully salvaged with surgery; however, locall... more ... Salvage therapy may be needed for recurrent or persistent disease after the use of chemoradiotherapy. ... Salvage therapy may be needed for recurrent or persistent disease after the use of chemoradiotherapy. ... What are the treatment protocols for salvage therapy in anal cancer?. Updated: Apr 07, 2020 ...
Salvage therapy is a broad term that is used for any treatment given when an illness hasnt responded to standard treatments. ... What is salvage therapy?. Salvage therapy is also known as rescue therapy. Salvage therapy isnt a specific treatment or ... What can I expect during salvage therapy?. Salvage therapy can take many different forms. The salvage therapy you receive will ... For example, salvage therapy for an 80-year-old person with lymphoma and heart disease will look different than salvage therapy ...
Until now, the goal of so-called salvage therapy has been to reduce the level of HIV in a patients bloodstream by a factor of ... In 60% to 65% of cases of salvage therapy, Dr. Hammer said, it will be possible to make the levels of HIV undetectable, defined ... The guidelines for changing therapy remain "pretty classical," Dr. Hammer said: Doctors should change initial therapy if the ... what medications to use for initial therapy, when to change the treatment regimen, and what new regimen to choose. ...
Many questions relating to salvage and HDC therapy for patients with Hodgkin lymphoma need to be addressed and are the subject ... Many questions relating to salvage and HDC therapy for patients with Hodgkin lymphoma need to be addressed and are the subject ... PET-adapted sequential salvage therapy with brentuximab vedotin followed by augmented ifosamide, carboplatin, and etoposide for ... What remains unknown about salvage and HDC therapy for Hodgkin lymphoma (Hodgkin disease)?. Updated: Sep 12, 2018 ...
... to Evaluate the Safety and Efficacy of Micafungin Salvage Mono-therapy Versus Active Control Intravenous Salvage Mono-therapy ... Micafungin Salvage Mono-therapy in Invasive Aspergillosis. The safety and scientific validity of this study is the ... Refractory to previous antifungal therapy; progression of infection. *Refractory to previous antifungal therapy; failure to ... patient with previous salvage therapy for the current episode of fungal infection ...
... and the choice of salvage therapy. Lawrence et al. selected salvage therapy on the basis of the resistance genotype and ... Key Data From Three Trials Investigating the Value of Treatment Interruption Before the Initiation of Salvage Therapy The Table ... The promise of a better response to salvage therapy on the one hand may be offset by the risk of increased immune suppression ... Partial or complete interruption of treatment may still have a role before the initiation of salvage therapy; perhaps the ...
Salvage radiation therapy (Three dimensional conformal radiation therapy (3D-CRT)/IMRT [Intensity-modulated radiation therapy ... Salvage radiation therapy (3D-CRT (Three dimensional conformal radiation therapy)/IMRT (Intensity-modulated radiation therapy ... Salvage radiation therapy (3D-CRT (Three dimensional conformal radiation therapy)/IMRT) 66.6-70.2 Gy given 1.8 Gy M-F for 37 - ... Randomized Salvage Radiation Therapy Plus Enzalutamide Post Prostatectomy. The safety and scientific validity of this study is ...
... jeopardizes outcomes from salvage treatments is a matter of debate still to be resolved. ... Whether focal therapy (FT) for prostate cancer (PC) ... Summary of "Salvage Local Treatments After Focal Therapy for ... Neoadjuvant Therapy. Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, ... Salvage Therapy. A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have ...
Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart. ... Myocardial salvage in acute myocardial infarction-challenges in clinical translation. J Mol Cell Cardiol. 2011;51:451-3.PubMed ... Na+/H+ exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol. 2002;39:747-53. ... Protecting the acutely ischemic myocardium beyond reperfusion therapies: are we any closer to realizing the dream of infarct ...
The main objective of the trial is to assess the therapeutic activity of idarubicin as salvage treatment in patients with ... Salvage Therapy With Idarubicin in Immunocompetent Patients With Relapsed or Refractory Primary Central Nervous System ... Salvage Therapy With Idarubicin in Immunocompetent Patients With Relapsed or Refractory Primary Central Nervous System ...
Salvage therapy. treatment outcome. Salvage therapy based on genotyping results. Treatment Failure. ... Genotyping Directed Salvage Therapy in Children Who Have Failed Dual NRTIs. The safety and scientific validity of this study is ... The HIV-NAT 013 phase II is a follow up study to evaluate treatment outcome after salvage therapy and the evolution of ... Clinical, Immunologic and Virological Outcomes of Genotyping Directed Salvage Therapy in Children Who Have Failed Dual NRTIs. ...
A. J. Stephenson, P. T. Scardino, M. W. Kattan et al., "Predicting the outcome of salvage radiation therapy for recurrent ... Evaluation of Serum Calcium as a Predictor of Biochemical Recurrence following Salvage Radiation Therapy for Prostate Cancer. ... "Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate ... "Evaluation of ki-67 staining levels as an independent biomarker of biochemical recurrence after salvage radiation therapy for ...
... Published 01 March 2021 Its now been ... There is emerging data on the clinical efficacy of PD-(L)1 antibody therapy for testicular germ cell tumors. Both pembrolizumab ... The above data imply that single checkpoint inhibitor therapy is unlikely to make major strides in the field of treatment- ... "Long-term outcome of salvage high-dose chemotherapy in patients with germ cell tumor with poor prognostic features" Urol Oncol ...
Stereotactic Body Radiation Therapy as Salvage for Intrathoracic Recurrence in Patients With Previously Irradiated Locally ... The mean follow-up after salvage SBRT was 22 months. Local failure following salvage was 11%, nodal failure was 37%, and ... Overall survival at 2 years from SBRT salvage was 79%. Salvage biological equivalent dose ≥100 Gy was predictive of improved ... improved outcomes following SBRT as a means of salvage for locally advanced recurrent NSCLC over traditional radiation therapy ...
Overactive bladder Anticholinergics Mirabegron Salvage therapy Neuromodulation Augmentation cystoplasty This article is part of ... Such "salvage" treatments suggested in the literature include pharmacologic therapy in combination or with behavioral ... focusing on therapies used in combination for OAB including behavioral therapy, pharmacologic therapy, neuromodulation, and ... Behavior therapy to enable drug discontinuation in the treatment of urge incontinence: a randomized controlled trial. Ann ...
Conclusions. Salvage therapy with a bismuth quadruple regimen is superior to triple therapies and is effective for second ... The aim of this study is to examine the efficacy of empiric salvage therapy as a second through sixth line treatment. Methods. ... Effectiveness of Second through Sixth Line Salvage Helicobacter pylori Treatment: Bismuth Quadruple Therapy is Almost Always a ... pylori treatment were offered empiric salvage therapy based on the patients previous antibiotic exposure. Enrollment occurred ...
Phase II Study of Gefitinib and Docetaxel as Salvage Therapy in Advanced Pancreatic Carcinoma. Trial Phase:. Phase 2. Minimum ... Initial therapy for metastatic pancreatic carcinoma is inadequate, and there is no effective. second line therapy. Docetaxel ... Phase II Study of Gefitinib and Docetaxel as Salvage Therapy in Advanced Pancreatic Carcinoma ... therapy is not considered a prior regimen for purpose of this study). - Disease must be measurable by RECIST criteria; ...
Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from INT 0114. Reviewer: Ryan Smith, MD ... Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from INT 0114 ... Adjuvant therapy consisted of 5-FU and radiation therapy in different combinations. ... This obviously selects for a better group of patients that would likely have a greater survival regardless of therapy. There is ...
Combination of Androgen Deprivation Therapy and Salvage Radiotherapy versus Salvage Radiotherapy Alone for Recurrent Prostate ... To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate ... including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT. The ADT-free duration after ... RT + ADT reduced the risk of biochemical progression after salvage treatment in patients with seminal vesicle invasion or ...
Salvage Therapy With High Dose Oral Clarithromycin in Relapsed or Refractory Extranodal Marginal Zone Lymphoma (HD-K). The ... Phase II Clinical Trial on the Activity of Salvage Therapy With High Dose Oral Clarithromycin in Patients With Relapsed or ... concomitant conventional or experimental antitumor therapy (chemotherapy, radiotherapy, immunotherapy, corticosteroids). * ... marginal zone cell B lymphoma or gastric Helicobacter pylori positive lymphoma refractory to conventional antibiotic therapy, ...
26 patients underwent salvage therapy, and 2 patients were not amenable to salvage. In 4 patients, local re-recurrence ... Salvage therapy is possible in ≥90% of recurrences, leading to 94% local disease control, with 78% organ preservation.« less ... Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with ... Impact of Salvage Therapy on Local Disease Control ... Impact of Salvage Therapy on Local Disease Control. *Citation ...
... as First-Line Treatment or Salvage Therapy in 309 Children With Steroid-Refractory Acute GVHD - read this article along with ... Consistent Outcomes Using Ryoncil™ as First-Line Treatment or Salvage Therapy in 309 Children With Steroid-Refractory Acute ... These cell therapies, with defined pharmaceutical release criteria, are planned to be readily available to patients worldwide. ... If approved, RYONCIL has the potential to be an effective and safe therapy to improve survival outcomes in the most vulnerable ...
"As such, our trial presents proof of principal that the addition of hormone-based therapy to salvage radiation therapy is ... Salvage radiation treatment combined with daily anti-androgen therapy for men with prostate cancer (PCa) that recurs or ... In a randomized, double-blind study of 760 PCa patients who underwent salvage radiation therapy, researchers found that ... Close more info about PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes ...
Recurrence of prostate cancer after initial treatment with radiation therapy (RT) is highly dependent on pretreatment risk ... A review of salvage treatment options for disease progression after radiation therapy for localized prostate cancer. June 3, ... We report on the efficacy and adverse effects of the currently available local salvage modalities including salvage radical ... While a full review of chemotherapy and advanced androgen therapies is beyond the scope of this article we briefly discuss ...
Local surgery or ablation therapy can be effective for local and/or regional recurrence of renal cell carcinoma after curative ... Salvage therapy usually was surgical excision, although a few patients were treated with ablative technologies such as ... Close more info about Local Salvage Therapy Effective for Local, Regional Recurrence of RCC ... Close more info about Local Salvage Therapy Effective for Local, Regional Recurrence of RCC ...
Learn about cell salvage therapies for injuries in the Lung Injury, Remodeling and Repair Laboratory of Rolf D. Hubmayr, M.D., ... Cell Salvage Therapies for Injuries. This is an optical section of an injured lung. The alveoli contain green fluorescein ...
To evaluate pre-operative prognostic risk factors to predict oncologic outcome of Salvage High-Intensity Focused Ultrasound (S- ... Locally recurrent prostate cancer after initial radiation therapy: Early salvage high-intensity focused ultrasound improves ... Median PSA nadir was 0.14ng/ml and 127 patients did not require androgen deprivation therapy (ADT). The mean follow up was ... PURPOSE: To evaluate pre-operative prognostic risk factors to predict oncologic outcome of Salvage High-Intensity Focused ...
... Loehrer PJ, Lauer ... Ifosfamide combination chemotherapy as third-line or greater therapy can produce durable complete remissions in heavily ... vigorous intravenous hydration therapy with normal saline (100 to 125 mL/h) was administered during the treatment course. ...
Adult T-cell leukemia-lymphoma (ATL) EPOCH regimen Salvage therapy This is a preview of subscription content, log in to check ... Here, we report results of a study of the EPOCH regimen as a salvage therapy for ATL. We retrospectively analyzed patients with ... Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II ... Outcome of patients with relapsed/refractory adult T-cell leukemia-lymphoma after salvage therapy. Rinsho Ketsueki. 2013;54(12 ...
  • The primary hypothesis of this study is that outcomes for patients with biochemically recurrent prostate cancer following radical prostatectomy will be improved by the addition of enzalutamide for 6-months compared to standard-of-care salvage radiation therapy to allow for further study in the definitive phase III setting. (clinicaltrials.gov)
  • Salvage radiotherapy for isolated prostate specific antigen increase after radical prostatectomy: evaluation of prognostic factors and creation of a prognostic scoring system," Journal of Urology , vol. 176, no. 3, pp. 985-990, 2006. (hindawi.com)
  • Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy," Journal of the American Medical Association , vol. 299, no. 23, pp. 2760-2769, 2008. (hindawi.com)
  • Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy," Journal of Clinical Oncology , vol. 25, no. 15, pp. 2035-2041, 2007. (hindawi.com)
  • Salvage radiotherapy for rising prostate-specific antigen levels after radical prostatectomy for prostate cancer: dose-response analysis," International Journal of Radiation Oncology Biology Physics , vol. 76, no. 3, pp. 735-740, 2010. (hindawi.com)
  • Salvage radiation treatment combined with daily anti-androgen therapy for men with prostate cancer (PCa) that recurs or persists following radical prostatectomy improves long-term overall survival compared with the use of salvage radiation treatment alone, according to a new study. (renalandurologynews.com)
  • We report on the efficacy and adverse effects of the currently available local salvage modalities including salvage radical prostatectomy, high dose rate and low dose rate brachytherapy, cryotherapy, high intensity focused ultrasound, and stereotactic body RT. (urotoday.com)
  • To compare relapse-free survival (RFS) in patients with HRPCa, treated primarily with radiotherapy (RT) + hormone therapy (HT) versus radical prostatectomy (RP) and salvage RT (sRT) ± HT when biochemical recurrence (BCR) appears. (elsevier.es)
  • BACKGROUND: To evaluate the outcome of patients treated with salvage radiotherapy after radical prostatectomy and to investigate the effects of independent predictors on survival. (minervamedica.it)
  • METHODS: From January 2000 to December 2015, 234 patients with biochemical/clinical recurrences after radical prostatectomy were submitted to salvage radiotherapy (SRT). (minervamedica.it)
  • Current salvage treatments for recurrent prostate cancer after primary radiation therapy include radical prostatectomy, cryosurgery and brachytherapy. (springer.com)
  • After radical prostatectomy, for example, patients with low risk local disease may not require secondary therapy or may benefit from salvage radiotherapy. (canjurol.com)
  • Contemporary Imaging Technologies for Men With Rising Prostate-Specific Antigen After Radical Prostatectomy and Before Early Salvage Irradiation: Where Do We Stand? (practiceupdate.com)
  • The aim of this study was to detail our experience performing salvage radical prostatectomy for patients who failed primary treatment of prostate cancer with radiation therapy. (elsevier.com)
  • We retrospectively queried our institutional database of radical prostatectomy cases for patients who underwent salvage surgery for radiationrecurrent prostate cancer. (elsevier.com)
  • Twenty-four patients with a mean age of 65 years (range 51-74) underwent salvage radical prostatectomy. (elsevier.com)
  • In carefully selected patients, salvage radical prostatectomy for radiation-recurrent prostate cancer is a treatment option with acceptable oncologic outcomes and a moderate complication rate. (elsevier.com)
  • Salvage radical prostatectomy is a treatment option for patients with recurrent cancer following radiation therapy. (elsevier.com)
  • This study was conducted to identify predictors of survival for patients treated with salvage radical prostatectomy. (elsevier.com)
  • The authors studied 86 prostate carcinoma patients who underwent salvage radical prostatectomy for locally persistent or recurrent prostate carcinoma at Mayo Clinic between 1967 and 1996. (elsevier.com)
  • Postirradiation Gleason score and DNA ploidy were highly predictive of the clinical outcomes of patients treated by salvage radical prostatectomy after radiation therapy. (elsevier.com)
  • Bostwick, David G. / Predictors of survival for prostate carcinoma patients treated with salvage radical prostatectomy after radiation therapy . (elsevier.com)
  • Our salvage radiation therapy nomogram predicts whether a recurrence of prostate cancer after radical prostatectomy can be treated successfully with salvage radiation therapy (external-beam radiation given after the prostate cancer returns). (mskcc.org)
  • Touijer, Karim A. / Topography of Prostate Cancer Recurrence After Radiation Therapy : A Detailed Mapping Study of Salvage Radical Prostatectomy Specimens . (elsevier.com)
  • AND PURPOSE The selection of appropriate candidates for salvage radiation therapy (SRT) to address a rising PSA following radical prostatectomy remains challenging. (elsevier.com)
  • Anorectal Cancer: Critical Anatomic and Staging Distinctions That Affect Use of Radiation Therapy. (medscape.com)
  • This study builds on the prior success of high-dose bicalutamide (for 24 months) when combined with salvage external radiation therapy (XRT), while using a newer more potent anti-androgen for a shorter duration of time (6 months) in an effort to minimize adverse effects. (clinicaltrials.gov)
  • Enzalutamide is an oral agent that is generally well tolerated and does not require concurrent steroid administration, which makes it an ideal candidate for combination with salvage radiation therapy (SRT). (clinicaltrials.gov)
  • The trial described here differs from Radiation Therapy Oncology Group (RTOG) 96-01, RTOG 05-34 and RADICALS in several ways. (clinicaltrials.gov)
  • Radiation therapy is considered a standard treatment option for the management of localized prostate cancer. (bioportfolio.com)
  • A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. (bioportfolio.com)
  • Evaluation of ki-67 staining levels as an independent biomarker of biochemical recurrence after salvage radiation therapy for prostate cancer," International Journal of Radiation Oncology Biology Physics , vol. 75, no. 5, pp. 1364-1370, 2009. (hindawi.com)
  • Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer," International Journal of Radiation Oncology Biology Physics , vol. 79, no. 5, pp. 1343-1349, 2011. (hindawi.com)
  • Evaluation of MDM2, p16, and p53 staining levels as biomarkers of biochemical recurrence following salvage radiation therapy for recurrent prostate cancer," Prostate , vol. 72, no. 16, pp. 1757-1766, 2012. (hindawi.com)
  • The purpose of this study is to provide data on the outcomes of using stereotactic body radiotherapy (SBRT) as a means of salvage for non-small cell lung cancer (NSCLC) relapses previously treated with radiation. (nih.gov)
  • We observed improved outcomes following SBRT as a means of salvage for locally advanced recurrent NSCLC over traditional radiation therapy options. (nih.gov)
  • Adjuvant therapy consisted of 5-FU and radiation therapy in different combinations. (oncolink.org)
  • Purpose: Previous studies have reported encouraging survival results and favorable toxicity data with stereotactic radiation therapy (SRT) for patients with persistent or progressive high grade glioma following standard therapy. (aacrjournals.org)
  • Materials and Methods: Between 1994 and 2008, 22 patients with clinical and/or radiographic imaging evidence of glioma progression following initial treatment were treated with hypofractionated stereotactic radiation therapy (H-SRT). (aacrjournals.org)
  • In a randomized, double-blind study of 760 PCa patients who underwent salvage radiation therapy, researchers found that patients who also received 24 months of daily bicalutamide had a statistically significant 23% lower risk of death at 12 years compared with patients who received daily placebo. (renalandurologynews.com)
  • The 2 groups had a similar incidence of late adverse events associated with radiation therapy, according to the investigators. (renalandurologynews.com)
  • Since the trial was designed, gonadotropin-releasing hormone (GnRH) agonists have superseded bicalutamide as the first-choice hormonal therapy with radiation therapy, the researchers pointed out. (renalandurologynews.com)
  • As such, our trial presents proof of principal that the addition of hormone-based therapy to salvage radiation therapy is associated with significant and clinically important lower rates of prostate-cancer metastases and death," they wrote. (renalandurologynews.com)
  • Patients also could not have previously received chemotherapy or radiation therapy for PCa. (renalandurologynews.com)
  • A review of salvage treatment options for disease progression after radiation therapy for localized prostate cancer. (urotoday.com)
  • Recurrence of prostate cancer after initial treatment with radiation therapy (RT) is highly dependent on pretreatment risk group and unfortunately, a proportion of patients fail primary treatment. (urotoday.com)
  • While a full review of chemotherapy and advanced androgen therapies is beyond the scope of this article we briefly discuss their use in the treatment of newly diagnosed recurrence after radiation. (urotoday.com)
  • Locally recurrent prostate cancer after initial radiation therapy: Early salvage high-intensity focused ultrasound improves oncologic outcomes. (biomedsearch.com)
  • Men with prostate-specific antigen (PSA) recurrences after prostatectomy have a high rate of failure despite salvage radiation and androgen deprivation therapy (ADT). (urotoday.com)
  • In this three-center prospective study known as the STREAM trial, we investigated the safety and effectiveness of enzalutamide given with salvage radiation therapy and ADT in men with PSA recurrence but no radiographic evidence of disease within four years of prostatectomy. (urotoday.com)
  • Overall, we found that adding six months of oral daily enzalutamide to standard salvage radiation and hormone therapy is safe and may improve prostate cancer remission rates at two and three years. (urotoday.com)
  • Salvage radiation therapy (RT) is a potentially curative treatment option for head and neck sarcomas (HNS) that did not respond to previous treatment(s). (jcancer.org)
  • Acute and late toxicities were evaluated using the Common Terminology Criteria for Adverse Events version 4.0 and the Radiation Therapy Oncology Group late radiation toxicity scoring system, respectively. (jcancer.org)
  • As such, the management of HNS usually requires a multidisciplinary approach with a combination of surgery, radiation therapy (RT), and depending on the histology, chemotherapy. (jcancer.org)
  • Pucar D, Hricak H, Shukla-Dave A, Kuroiwa K, Drobnjak M, Eastham J et al (2007) Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence. (springer.com)
  • For men with prostate cancer who have a low prostate-specific antigen (PSA) level prior to salvage radiation therapy (SRT), adding an antiandrogen may increase the risk of other-cause mortality by twofold or more, according to investigators. (mdedge.com)
  • Results from the present analysis paint a more complex picture, revealing that patients with low PSA levels who received hormone therapy had a higher rate of other-cause mortality, primarily because of high-grade cardiac and neurologic events, reported lead author Daniel Spratt, MD , of the University of Michigan Rogel Cancer Center, Ann Arbor, who presented findings at the annual meeting of the American Society for Radiation Oncology. (mdedge.com)
  • The current guidelines recommend that all men be offered hormone therapy when receiving salvage radiation therapy, but our data demonstrate that men with lower PSA's are probably more harmed than helped by long-term hormone therapy," Dr. Spratt concluded. (mdedge.com)
  • Thus, PSA prior to salvage radiation actually is not only prognostic, it predicts who will benefit most from hormone therapy, and guidelines should now be updated to reflect this finding. (mdedge.com)
  • Prior treatments included PDT in five patients, radiation therapy in one patient and systemic retinoid therapy in another patient. (arvojournals.org)
  • This study will explore the role of salvage pelvic image-guided intensity-modulated radiation therapy (IMRT) combined with ADT administered for 6 months in pelvic oligometastatic patients in prolonging the failure-free interval between two consecutive ADT courses, or even to cure selected patients with limited metastatic burden. (inserm.fr)
  • PURPOSE: We assessed the efficacy, complications and technical advancements in salvage cryosurgical ablation of the prostate for recurrent prostate cancer after radiation therapy. (canjurol.com)
  • The decision to add hormonal therapy to salvage radiation therapy (SRT) should be individualized. (elsevier.com)
  • The mean interval from radiation therapy to biopsy-proven recurrence was 3.7 years (range, 6 months to 17 years). (elsevier.com)
  • From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. (mskcc.org)
  • In men who do not respond to initial radiation therapy, accurate knowledge of the site of cancer recurrence or persistence is necessary to understand treatment failure. (elsevier.com)
  • When recurrence of prostate cancer after radiation therapy is suspected, biopsy focused on the distal apex, periurethral area, and seminal vesicles-areas that are not routinely biopsied-is necessary. (elsevier.com)
  • What was your PSA value from the most recent laboratory report, or the value immediately before starting salvage radiation therapy? (mskcc.org)
  • By the study's definition, I'm still in the "very early" group-the group with the best survival if salvage radiation therapy (SRT) is started while I'm still in that group. (dansjourney.com)
  • Dear Dan, I am in a very similar situation except that I underwent radiation therapy four years ago. (dansjourney.com)
  • I'm in no rush to start salvage radiation therapy until we know what we're truly dealing with for the very reasons you mentioned. (dansjourney.com)
  • To evaluate the efficacy and safety of micafungin in patients with proven invasive aspergillosis and who are refractory or intolerant to previous systemic antifungal therapy. (clinicaltrials.gov)
  • 2-4 However, patients with cisplatin-refractory disease or progressive disease following high-dose salvage chemotherapy and autologous stem cell rescue, harbor an extremely dim prognosis. (urotoday.com)
  • The above data imply that single checkpoint inhibitor therapy is unlikely to make major strides in the field of treatment-refractory testicular germ cell tumors. (urotoday.com)
  • In this review article, we outline combination therapies such as adding mirabegron to solifenacin, anticholinergic medication in addition to either behavioral therapy or various types of neuromodulation and using neuromodulation after failed botulinum toxin injections are efficacious treatment approaches and have shown to be superior to monotherapy for the treatment non-neurogenic refractory OAB. (springer.com)
  • Management of overactive bladder refractory to medical therapy. (springer.com)
  • 3. Axt L, Naumann A, Toennies J (2019) Retrospective single center analysis of outcome, risk factors and therapy in steroid refractory graft-versus-host disease after allogeneic hematopoietic cell transplantation. (biospace.com)
  • We retrospectively analyzed patients with relapsed or refractory ATL treated in our institution, with EPOCH as a first salvage therapy. (springer.com)
  • Outcome of patients with relapsed/refractory adult T-cell leukemia-lymphoma after salvage therapy. (springer.com)
  • Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study. (springer.com)
  • Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. (haematologica.org)
  • For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy. (haematologica.org)
  • In conclusion, metronomic therapy is an effective late salvage treatment in relapsed/refractory multiple myeloma, with a high overall response rate and a favorable toxicity profile. (haematologica.org)
  • One hundred and eighty-six patients with relapsed/refractory MM between 31 and 82 years of age received at least one cycle of metronomic therapy at the Myeloma Institute of Research and Therapy of the University of Arkansas for Medical Sciences (Little Rock, AR, USA) between March 2004 and January 2012. (haematologica.org)
  • It is not an approved therapy for seizure states, but rather for refractory depression and diffcult-to-control schizophrenia. (nyp.org)
  • This pilot trial was initiated in order to evaluate the efficacy and tolerability of continuous low-dose GM-CSF as salvage in various chemotherapy-refractory carcinomas. (cancernetwork.com)
  • R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. (haematologica.org)
  • Design and Methods We retrospectively analyzed 163 patients with relapsed or refractory diffuse large B-cell lymphoma who received R-ESHAP as salvage therapy with a curative purpose. (haematologica.org)
  • To date, high-dose therapy followed by autologous stem-cell transplantation (ASCT) is the reference treatment for patients with relapsed or primary refractory aggressive non-Hodgkin's lymphoma, provided that the disease is sensitive to second-line chemotherapy. (haematologica.org)
  • Conclusion Salvage therapy with CLARA and subsequent conditioning with clofarabine and melphalan prior to allogeneic HCT provides good anti-leukemic activity in patients with relapsed or refractory AML. (aspergillus.org.uk)
  • Conclusion: These two cases suggested that sorafenib might be utilized as a potent salvage therapy for some refractory/relapsed AML patients without the FLT3-ITD mutation. (eurekaselect.com)
  • Nan Yang, Zhenyang Gu, Zhanxiang Liu, Wenrong Huang, Shuhong Wang, Lili Wang and Chunji Gao*, "Sorafenib as a Salvage Therapy in FLT3-ITD Negative Relapse/ Refractory Acute Myeloid Leukemia", Anti-Cancer Agents in Medicinal Chemistry (2018) 18: 1489. (eurekaselect.com)
  • We report a case of a 17-year-old male with severe UC refractory to IV steroids with successful sequential salvage therapy guided by serum IFX level. (gi.org)
  • This case demonstrates the possibility of therapeutic drug monitoring of IFX levels when calculating the risk/benefit ratio for patients with steroid-refractory UC failing primary salvage therapy. (gi.org)
  • A recent randomized trial of these agents in IV steroid-refractory patients found no difference in efficacy, but 40% of patients did not respond to the therapy in either arm. (gi.org)
  • ReLApsE is a randomized, open, multicenter trial that enrolled patients in first to third relapse who had received induction with Rd. Patients were excluded if they had prior salvage AHCT or were refractory to lenalidomide or had progressive disease within six months of lenalidomide treatment. (ashclinicalnews.org)
  • abstract = "Background: To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). (elsevier.com)
  • Presalvage PSA ≥0.6 ng/mL, pathologic stage ≥T3b, and RT + ADT were significantly associated with biochemical progression after salvage treatment. (nih.gov)
  • Pound CR, Brawer MK, Partin AW (2001) Evaluation and treatment of men with biochemical prostate-specific antigen recurrence following definitive therapy for clinically localized prostate cancer. (springer.com)
  • Forty-seven patients underwent salvage cryosurgery and biochemical recurrence free survival and complications were retrospectively reviewed. (canjurol.com)
  • Salvage cryotherapy in experienced hands utilizing third-generation technology provides for excellent biochemical control with minimal morbidity. (canjurol.com)
  • Five-Year Biochemical Progression-Free Survival Following Salvage Whole-Gland Prostate Cryoablation: Defining Success with Nadir Prostate-Specific Antigen. (semanticscholar.org)
  • To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. (nih.gov)
  • Salvage prostatectomy series have demonstrated durable long term control. (termedia.pl)
  • 0.1 ng/ml for the salvage prostatectomy group ( n = 44) and PSA nadir + 2.0 ng/ml (Phoenix definition) for the salvage cryosurgery ( n = 54) and salvage brachytherapy group ( n = 31). (springer.com)
  • When at least one regimen containing protease inhibitors has failed in a patient, the subsequent attempts to treat the HIV infection may be referred to as salvage therapy. (wikipedia.org)
  • International experts reviewed published, peer-reviewed literature on HIV/AIDS to come up with the new guidelines, which counsel doctors on when to begin treatment, what medications to use for initial therapy, when to change the treatment regimen, and what new regimen to choose. (medpagetoday.com)
  • The guidelines for changing therapy remain "pretty classical," Dr. Hammer said: Doctors should change initial therapy if the regimen is failing because of resistance, or if it is inconvenient, intolerable or toxic. (medpagetoday.com)
  • Patients with multidrug-resistant HIV and HIV RNA levels of more than 5000 copies per milliliter either started a salvage regimen immediately (the control group) or stopped antiretroviral treatment for four months before starting the salvage regimen (the treatment-interruption group). (natap.org)
  • Regarding HIV RNA concentrations, the salvage regimen had similarly disappointing results in the two groups: in only one in five patients was the viral load reduced to less than 400 copies per milliliter. (natap.org)
  • Salvage therapy with a bismuth quadruple regimen is superior to triple therapies and is effective for second through fifth line empirical treatment (≥85% PP, ≥70% ITT). (hindawi.com)
  • We propose that the combination of docetaxel with Gefitinib will have activity against pancreatic carcinoma, whether the regimen is administered as first or second-line therapy for metastatic disease. (knowcancer.com)
  • Here, we report results of a study of the EPOCH regimen as a salvage therapy for ATL. (springer.com)
  • In an earlier investigation with ledipasvir/sofosbuvir (Harvoni) as a salvage regimen after failures on daclatisvir (Daklinza) and investigative therapy asunaprevir, Akuta and colleagues achieved sustained virologic response (SVR) in only 70% of patients. (mdmag.com)
  • 6 PI resistance mutations were more likely to show a virologic response to the LPV/r-containing salvage regimen. (i-base.info)
  • Of note, the CD4 nadir prior to adding LPV/r was a better than absolute CD4 in predicting success if the salvage regimen. (i-base.info)
  • Keep in mind that salvage therapy can include clinical trials and experimental medications with unknown outcomes. (healthline.com)
  • prostate cancer (PC) jeopardizes outcomes from salvage treatments is a matter of debate still to be resolved. (bioportfolio.com)
  • Complications, oncological and functional outcomes of salvage treatment options following focal therapy for localized prostate cancer: a systematic review and a comprehensive narrative review. (bioportfolio.com)
  • If approved, RYONCIL has the potential to be an effective and safe therapy to improve survival outcomes in the most vulnerable population of children with severe forms of this disease who can have mortality rates as high as 90 percent. (biospace.com)
  • Men with resected node-positive disease (n = 8) had poorer outcomes, with only 25% in remission at two years, suggesting the need for escalation of therapy in this subgroup. (urotoday.com)
  • As most centers perform only one preferred salvage technique, the literature only describes single-center outcomes from a single salvage technique with a limited number of patients. (springer.com)
  • Treatment failure after primary and salvage therapy for prostate cancer: likelihood, patterns of care, and outcomes. (springer.com)
  • To determine early visual acuity outcomes after beginning Macugen therapy as a salvage treatment for subfoveal CNV in AMD patients. (arvojournals.org)
  • A retrospective chart review of visual acuity outcomes of AMD patients who underwent Macugen salvage therapy (prior treament of CNV or chronic PED) for subfoveal CNV by one physician. (arvojournals.org)
  • Pathological, Oncologic and Functional Outcomes of a Prospective Registry of Salvage High Intensity Focused Ultrasound Ablation for Radiorecurrent Prostate Cancer. (semanticscholar.org)
  • Long-Term Oncologic Outcomes of Salvage Cryoablation for Radio-Recurrent Prostate Cancer. (semanticscholar.org)
  • Patients were assessed for the risk of complications and oncologic outcomes following salvage surgery. (elsevier.com)
  • 26 of these patients had salvage therapy consisting of abdominoperineal resection, and of these patients, 43% had long-term 5-y survival and control of their disease. (medscape.com)
  • The outlook after salvage therapy depends on the condition that's being treated, but 5-year survival rates after salvage therapy will always be lower than rates for your overall condition. (healthline.com)
  • Highly active antiretroviral therapy (HAART) improves survival in HIV-associated Hodgkin's disease: results of a multicenter study. (medscape.com)
  • Salvage biological equivalent dose ≥100 Gy was predictive of improved progression-free survival (48% vs. 18%, P=0.021) and overall survival (91% vs. 52%, P=0.004) at 2 years. (nih.gov)
  • This obviously selects for a better group of patients that would likely have a greater survival regardless of therapy. (oncolink.org)
  • Local recurrence-free survival was compared while taking into account Watch and Wait strategy alone and Watch and Wait plus salvage. (osti.gov)
  • Local recurrence-free survival at 5 years was 69% (all local recurrences) and 94% (after salvage procedures). (osti.gov)
  • In patients with a higher burden of metastatic disease, there is emerging evidence that chemotherapy and advanced androgen therapy can improve survival. (urotoday.com)
  • Investigators who studied patients with local or regional cancer recurrence after curative surgery for localized renal cell carcinoma (RCC) found that almost half of those who underwent local salvage therapy had a 2-year secondary recurrence-free survival rate of nearly 50% without the need for systemic therapy. (renalandurologynews.com)
  • Patients with a solitary site of recurrence may be most appropriate for local therapy, although durable disease-free survival was also observed in patients with multiple sites of recurrence," Dr Pierorazio and colleagues concluded. (renalandurologynews.com)
  • These data suggest that prior cytotoxic therapy decreases marrow response rates to HAs but not survival. (sigmaaldrich.com)
  • Univariate and multivariate analysis of the variables that may influence relapse-free survival rates after salvage thereapy. (elsevier.es)
  • 1 - 3 Among patients with chemosensitive disease, the remission status at transplant has a significant impact on the outcome, because patients in complete remission before high-dose therapy achieve better long-term progression-free survival than patients who undergo transplantation in partial remission. (haematologica.org)
  • WITH THE INCLUSION of proteasome inhibitors and immunomodulatory agents first into salvage and then as components of first-line, consolidation, and maintenance regimens, response rates, depth of response, and median progression-free and overall survival have all improved for patients suffering from multiple myeloma. (ascopost.com)
  • While the combined use of high-dose melphalan and autologous stem cell transplantation plays a prominent consolidative role in transplant-eligible patients following induction therapy as well as in relapse, there is an ongoing need to improve upon both salvage and induction regimens to further prolong survival on our way to curing this disease. (ascopost.com)
  • This finding was drawn from a secondary analysis of the NRG Oncology/RTOG 9601 phase 3 trial, a practice-changing study that showed that 2 years of antiandrogen therapy with bicalutamide improved overall survival when added to SRT, compared with that of SRT alone. (mdedge.com)
  • We now have three randomized trials with over 2,400 men in total, [none of which showed that] short- or long-term hormone therapy improves overall survival in men [with a low PSA level who receive] early salvage radiotherapy. (mdedge.com)
  • Two years of bicalutamide monotherapy resulted in higher rates of gynecomastia with a trend for worse survival when given in favorable risk patients, and 6 mo of luteinizing hormone-releasing hormone agonist therapy resulted in higher rates of hot flashes and long-term hypertension. (elsevier.com)
  • The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. (nature.com)
  • In the present study, we conducted dose escalations of ifosfamide and mitoxantrone to see whether a 2-3 fold increase in the conventional dose could improve the response rates, thereby increasing the chances of subsequent transplant therapy (TT) for potential long-term survival. (elsevier.com)
  • Median PSA nadir was 0.14ng/ml and 127 patients did not require androgen deprivation therapy (ADT). (biomedsearch.com)
  • Those with higher risk disease, based on PSA kinetics and tumor pathology may require systemic androgen deprivation therapy (ADT) with or without radiotherapy. (canjurol.com)
  • Presenting with a low burden of metastatic disease (≤5 lesions), this new sub-group lies between true metastatic prostate cancer patients for whom androgen- deprivation therapy (ADT) is the mainstay of treatment, and patients with a rising PSA, but no visible lesion on conventional imaging, in whom intermittent ADT has been shown to be no less effective than continuous ADT. (inserm.fr)
  • Fourteen of these patients (58%) received androgen deprivation therapy prior to surgery. (elsevier.com)
  • Neoadjuvant/concurrent Androgen-Deprivation Therapy? (riskcalc.org)
  • Salvage chemotherapy is a treatment that is given after the cancer has not responded to other chemotherapy regimens. (wikipedia.org)
  • In these situations, palliative chemotherapy, with regimens containing oxaliplatin, is limited in efficacy, and targeted biologic therapies have also shown limited efficacy. (urotoday.com)
  • But, once daily regimens may be particularly useful for directly observed therapy. (natap.org)
  • Among them, a moderate activity of currently available salvage regimens and accumulating toxicity of chemotherapy may prevent from transplantation. (aspergillus.org.uk)
  • Patients had received one to three prior regimens, and those with prior proteasome exposure had to have a prior response, had to come off proteasome inhibitor therapy for reasons other than toxicity, and must have been off proteasome inhibitor therapy for 6 months or more. (ascopost.com)
  • Glecanprevir plus pibrentasvir (Mavyret) was successfully used as a salvage therapy for patients with hepatitis C virus (HCV) infection in a real-world setting, regardless of the number of prior failures with NS5A regimens or emergence of NS5A resistance-associated variants (RAVs), according to a new study. (mdmag.com)
  • This was not, they reported, 'adequate treatment efficacy as a salvage therapy for failures of prior NS5A regimens. (mdmag.com)
  • Of those screened, 83 were treated with G/P for failures of prior DAA regimens, and 20 were able to be included in the intention-to-treat analysis of the 12 weeks of therapy. (mdmag.com)
  • We have demonstrated in the present retrospective study that G/P can be considered a potential salvage therapy for HCV failures to prior DAA regimens in real-world setting, regardless of the number of times of prior treatment, prior treatment response, and fibrosis stage,' investigators concluded. (mdmag.com)
  • The study, ' Favorable efficacy of glecaprevir plus pibrentasvir as salvage therapy for HCV failures to prior direct‐acting antivirals regimens ,' was published online in the Journal of Medical Virology . (mdmag.com)
  • What are the treatment protocols for salvage therapy in anal cancer? (medscape.com)
  • Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. (medscape.com)
  • Salvage therapy is a term for any treatment you receive after standard treatments have failed. (healthline.com)
  • Salvage therapy isn't a specific treatment or medication. (healthline.com)
  • The side effects of salvage therapy will depend on the type of treatment you're receiving. (healthline.com)
  • The development of new drugs illustrates the continual refinement of the treatment options, Dr. Hammer said, but the recommendations for initial therapy remain essentially unchanged. (medpagetoday.com)
  • Why not stop, avoid the inconvenience, expense, and side effects of treatment, wait for a sensitive virus to replace the resistant one, and thus improve the chances of eventual salvage therapy? (natap.org)
  • The theoretical foundations of interrupting treatment before the initiation of salvage therapy have also come under attack. (natap.org)
  • The HIV-NAT 013 phase II is a follow up study to evaluate treatment outcome after salvage therapy and the evolution of mutations. (clinicaltrials.gov)
  • The aim of this study is to examine the efficacy of empiric salvage therapy as a second through sixth line treatment. (hindawi.com)
  • In this single gastroenterology center prospective study in Montreal, Canada, patients with failed H. pylori treatment were offered empiric salvage therapy based on the patients' previous antibiotic exposure. (hindawi.com)
  • Consistent safety and efficacy were observed across the continuum from first-line treatment after steroid failure through the most challenging patients who received RYONCIL as salvage after exhausting all other options. (biospace.com)
  • If disease remains locally confined, salvage treatment with a variety of techniques can still provide a potential cure. (urotoday.com)
  • We review the relevant literature on available salvage treatment options and appropriate patient selection for patients with recurrent prostate cancer after RT. (urotoday.com)
  • A significant proportion of patients benefit from this treatment as a salvage therapy postponing the delivery of chemotherapy. (haematologica.org)
  • In addition, vigorous intravenous hydration therapy with normal saline (100 to 125 mL/h) was administered during the treatment course. (uni-bonn.de)
  • After exhausting conventional therapies, Dr. Kandula and the ICU team in consultation with the patient's family discussed electroconvulsive therapy (ECT) as an alternative treatment. (nyp.org)
  • The idea of using ECT earlier in the status epilepsy treatment armamentarium, and not just as salvage therapy, remains an active area of exploration. (nyp.org)
  • While h-ATG may be utilized in the salvage setting, the overall response rate likely will be lower than when h-ATG is used as initial treatment. (aamds.org)
  • Primary endpoint was treatment success defined as a complete remission (CR, CR(i)) six weeks after completion of therapy. (aspergillus.org.uk)
  • One patient responded to chemotherapy but needed surgical intervention due to a pulmonary aspergillosis and could not proceed with therapy within the projected timelines and was therefore considered as treatment failure. (aspergillus.org.uk)
  • Ceftazidime-avibactam treatment led to emergence of resistance, and alternative combination therapy failed due to persistent infection and toxicity. (asm.org)
  • Prior to the approval of novel β-lactam/β-lactamase-inhibitor combinations, treatment of CRE infection consisted of combination therapy with "agents of last resort. (asm.org)
  • However, aggressive salvage treatment options should be offered with great care, because reported failure rates as well as toxicity rates can be significant, especially in inexperienced hands, regardless of salvage technique [7]. (termedia.pl)
  • This phase I-II study assessed the safety and efficacy of IPDT for patients with persistent or recurrent head and neck cancer unsuitable for further treatment with surgery, radiotherapy or chemotherapy, recruited for 'last hope' salvage treatment. (semanticscholar.org)
  • Interstitial low-dose-rate brachytherapy as a salvage treatment for recurrent head-and-neck cancers: long-term results. (semanticscholar.org)
  • Photodynamic therapy: a clinical reality in the treatment of cancer. (semanticscholar.org)
  • We report the first clinical experience of carbon ion radiotherapy (CIRT) for salvage treatment of locally recurrent (LR) or RT-induced secondary HNS after surgery and/or radiotherapy. (jcancer.org)
  • The median time between the completion of initial treatment (either surgery only or surgery followed by adjuvant RT) and salvage CIRT was 30.6 months. (jcancer.org)
  • Two patients irradiated for a second primary sarcoma had Grade 4 bleeding during CIRT, including one who experienced the rupture of an optic artery aneurysm unrelated to his disease or the salvage treatment. (jcancer.org)
  • Patients should be selected with great care before offering these salvage treatment strategies. (springer.com)
  • Treatment with high dose daptomycin as salvage therapy was generally effective and safe in Taiwan. (biomedcentral.com)
  • The investigators turned to glecanprevir/pibrentasvir (G/P) for their new study of salvage therapy, identifying 239 patients admitted between November 2017 and May 2018 for treatment of chronic HCV infection of genotype 1b, 2a, or 2b without decompensated cirrhosis or hepatocellular carcinoma. (mdmag.com)
  • We review the literature and discuss the current methods of risk assessment and the treatment options in prostate cancer once primary therapy fails. (canjurol.com)
  • This article seeks to explore the currently utilized modalities for salvage treatment for radiorecurrent PCa. (semanticscholar.org)
  • Is Salvage Hyperbaric Oxygen Therapy Effective for Sudden Sensorineural Hearing Loss in Patients with Non-response to Corticostreoid Treatment? (cureus.com)
  • Group B: patients receiving corticosteroid treatment within the first 14 days, but unresponsive to this treatment, and began to receive HBOT after three weeks of the onset of SSNHL for the purpose of salvage therapy. (cureus.com)
  • It was observed that salvage HBOT was not effective when the initial and post-treatment audiometric tests were compared. (cureus.com)
  • Conclusion: According to our results, salvage HBOT was not efficient when performed three weeks after the onset of the SSNHL for patients who did not respond to corticosteroid treatment. (cureus.com)
  • However, in the majority of the cases, the etiology remains unknown and corticosteroid therapy is given to all of the patients as it is the only mode of treatment with proven efficacy currently [4-5] . (cureus.com)
  • Until recently, the treatment of HCV involved interferon therapy, which had limited efficacy and was poorly tolerated. (mja.com.au)
  • At our University Medical Center 12 patients with severe LD (positive Legionella urinary antigen n=8, elevated L. pneumophilia antibody n=4) received TG salvage therapy after failure of initial treatment with azithromycin (AZ) n=6 or LVX and AZ n=6 between 1/2008 and 2/2016. (confex.com)
  • With the advent of target therapies, imatinib became the mainstay for treatment of chronic myeloid leukemia. (mjhid.org)
  • The intent of the blog is not to promote any therapy, product or treatment but to continue sharing our experiences and knowledge as it relates to VNS. (blogspot.com)
  • I recently had two appointments with medical oncologists (one at a renown institution) and both are very reluctant to start any type of salvage treatment until recurrence is confirmed, which typically would require a PSA of 2.05 since my nadir was .05. (dansjourney.com)
  • Nonsurgical Salvage Local Therapies for Radiorecurrent Prostate Cancer: A Systematic Review and Meta-analysis. (bioportfolio.com)
  • PURPOSE: To evaluate pre-operative prognostic risk factors to predict oncologic outcome of Salvage High-Intensity Focused Ultrasound (S-HIFU) for radiorecurrent prostate cancer (PCa). (biomedsearch.com)
  • Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results from the ARMYDA-6 MI (Antiplatelet therapy for Reducton of MYocardial Damage during Angioplasty-Myocardial Infarction) randomized study. (springer.com)
  • Pooled outcome rates for each salvage strategy and pooled odds ratio comparing the two strategies were calculated using the random effects model. (harvard.edu)
  • In this overview, five high-volume Dutch centers describe their toxicity and outcome data using different salvage techniques. (springer.com)
  • Methods: We performed a meta-analysis of trials published in PubMed up to January 2015 relating to the use of third-line salvage therapy following failure of intravenous corticosteroids and infliximab or cyclosporine. (harvard.edu)
  • Methods: Between June 1993 and June 2003, 48 pts with HM and definite or probable IA (according to EORTC/MSG criteria) received salvage therapy with POS while 39 similar pts received AmB/LPD alone or AmB/LPD plus IT (25 Pts). (aspergillus.org.uk)
  • Kimura M, Mouraviev V, Tsivian M, Mayes JM, Satoh T, Polascik TJ (2010) Current salvage methods for recurrent prostate cancer after failure of primary radiotherapy. (springer.com)
  • METHODS: A total of 58 patients were evaluated for salvage cryosurgery using an algorithm of capromab pendetide scan and prostate biopsy from January 2003-July 2007. (canjurol.com)
  • These results suggest that only a minority can be successfully salvaged after receiving as first therapy either r-ATG or cyclophosphamide. (aamds.org)
  • Fourteen patients have died due to disease progression, two patients are alive and on alternative therapies. (nih.gov)
  • Therapy was continued until progression or refusal by the patient. (cancernetwork.com)
  • Notably, 6 of 7 responders but only 1 of 8 patients with disease progression developed leukocytosis during therapy. (cancernetwork.com)
  • Carfilzomib (Kyprolis), an irreversible proteasome inhibitor, has shown promising activity in a pivotal phase II trial of patients who either have not responded to or had disease progression on prior therapies, which could have included bortezomib. (ascopost.com)
  • Three patients developed local progression, and another 3 developed distant metastasis after salvage CIRT. (jcancer.org)
  • Patients were treated until disease progression (with lenalidomide maintenance in the salvage-AHCT group and Rd in the continuous-therapy group). (ashclinicalnews.org)
  • Local recurrence after radiotherapy has the options of cryotherapy, brachytherapy or salvage surgery. (canjurol.com)
  • Hematologic toxicity grading was problematic as 146 of 186 (78%) of patients presented with at least grade 2 thrombocytopenia within 90 days prior to starting metronomic therapy. (haematologica.org)
  • Because toxicity and failure rates are considerable, salvage treatments are not commonly performed. (springer.com)
  • Significant failure and toxicity rates are observed, regardless of salvage technique. (springer.com)
  • Context: Salvage radiotherapy (SRT) is a standard of care for men who recur postprostatectomy, and recent randomized trials have assessed the benefit and toxicity of adding hormone therapy (HT) to SRT with differing results. (elsevier.com)
  • Purpose: To review the risk of local recurrence and impact of salvage therapy after Watch and Wait for rectal cancer with complete clinical response (cCR) after chemoradiation therapy (CRT). (osti.gov)
  • The investigators also found that 2 or more sites of LR or RR significantly predicted a 2.2-fold increased risk of secondary recurrence or metastasis after local therapy for local recurrence. (renalandurologynews.com)
  • Salvage therapy is possible in ≥90% of recurrences, leading to 94% local disease control, with 78% organ preservation. (osti.gov)
  • There are some people who really benefit [from hormone therapy], some who don't benefit, and some who just might be harmed, so I think we can be much more thoughtful and cautious in the future. (mdedge.com)
  • DISCUSSION: This multicenter prospective phase II study will yield new data regarding the safety and efficacy of high-dose radiotherapy combined with ADT and will provide a basis for a larger phase III study to examine the role of radiotherapy in this population currently treated only with hormone therapy. (inserm.fr)
  • Patient summary: In this report, we performed a systematic review of the literature to determine the benefit and harm of adding hormone therapy to salvage radiotherapy (SRT) for recurrent prostate cancer. (elsevier.com)
  • We found that the benefit of hormone therapy varied by important prognostic factors, including pre-SRT prostate-specific antigen, Gleason grade, and surgical margin status. (elsevier.com)
  • Our group then developed a framework on how best to utilize hormone therapy with SRT. (elsevier.com)
  • We identified 186 patients who had been treated with metronomic therapy between March 2004 and January 2012 with a median follow up of 24.2 months. (haematologica.org)
  • Median number of prior therapies was 14 (range 1-51). (haematologica.org)
  • Median number of completed metronomic therapy cycles was 1 (range 1-5), while 45 of 186 (25%) received 2 or more cycles. (haematologica.org)
  • The median dose of salvage CIRT was 60 GyE. (jcancer.org)
  • at the time of switch to TG, SOFA score was 6 (1-9) with respiratory worsening present in 11/12 patients after median of 4 (2-8) days of initial therapy. (confex.com)
  • These patients received salvage therapy with TG 100 mg x 1 dose, followed by 50 mg IV q12h in addition to LVX n=5, AZ n=3, LVX and AZ n=3, or as monotherapy n=1 for median of 8 (4-17) days. (confex.com)
  • All patients received i.v. cidofovir for a median of 21 days (range, 5-90 days) before CMX001 therapy. (elsevier.com)
  • Salvage therapy, in this context, is the attempt to contain the replicating HIV once the usual line of treatments have been exhausted. (wikipedia.org)
  • Generally, salvage therapy consists of medications that are known to have more severe side effects than earlier treatments. (healthline.com)
  • The term salvage therapy is primarily used to describe treatments for HIV and cancer . (healthline.com)
  • For example, treatments for patients with end stage renal disease (ESRD) who are no longer responding to dialysis might also be referred to as salvage therapy. (healthline.com)
  • That's because salvage therapy is given when other treatments have failed. (healthline.com)
  • Salvage Local Treatments After Focal Therapy for Prostate Cancer. (bioportfolio.com)
  • Whether focal therapy (FT) jeopardizes subsequent prostate cancer (PCa) salvage treatments, when needed, remains a major concern and is largely unknown. (bioportfolio.com)
  • Even in this situation, approximately 50% can still be cured with salvage treatments, either with more conventional cisplatin-based chemotherapy or with high-dose chemotherapy and autologous stem cell rescue. (urotoday.com)
  • Such "salvage" treatments suggested in the literature include pharmacologic therapy in combination or with behavioral modification, various forms of neuromodulation with medication, alternative forms of neuromodulation, with or without prior botulinum toxin injections, and lastly, augmentation cystoplasty. (springer.com)
  • This information will help tailor successful salvage treatments. (elsevier.com)
  • However, almost 50% of patients with LR or RR in this select surgical/ablative series demonstrated a disease-free interval without the need for systemic therapy. (renalandurologynews.com)
  • As with most implanted medical device-related infections, standard practice traditionally involves complete hardware removal, systemic antibiotic therapy, and subsequent reimplantation of the device. (blogspot.com)
  • In the case of HIV, the first-line therapy is antiretroviral medication . (healthline.com)
  • In a retrospective cohort study of salvage antiretroviral combination therapy including efavirenz, 60% of 51 patients were able to suppress HIV RNA by at least 1 log10 or to less than 50 copies/ml. (ubc.ca)
  • With increased availability of antiretroviral therapy in South Africa over the last decade, HIV mortality has decreased and life expectancy has increased, with greater improvements in women versus men, according to a study published in PLOS Medicine . (thebodypro.com)
  • All participants in the study were failing their current antiretroviral therapy (ART) and had viral loads over 400 copies/ml. (aidsmap.com)
  • With few observed acute and late toxicities, salvage CIRT can provide effective short-term tumor control. (jcancer.org)
  • and purpose: To assess the efficacy and safety of salvage stereotactic body radiotherapy (SBRT) in patients with biopsy-proven local prostate cancer recurrence after radiotherapy. (bioportfolio.com)
  • Salvage Radiopeptide Therapy of Advanced Castrate-Resistant Prostate Cancer with Lutetium-177-Labeled Prostate-Specific Membrane Antigen: Efficacy and Safety in Routine Practice. (americanelements.com)
  • We sought to assess the efficacy and safety of this third-line salvage therapy. (harvard.edu)
  • Further research, preferably in a prospective fashion, will be required to confirm the efficacy and safety of salvage CIRT in this patient population. (jcancer.org)
  • The promise of a better response to salvage therapy on the one hand may be offset by the risk of increased immune suppression on the other. (natap.org)
  • Salvage stereotactic body radiotherapy for local prostate cancer recurrence after radiotherapy: a retrospective multicentre study of the GETUG. (bioportfolio.com)
  • SAN DIEGO , April 18, 2016 /PRNewswire/ -- Polaris Group announced today that ADI-PEG 20, arginine deiminase formulated with polyethylene glycol, is a potential salvage therapy for BRAF inhibitor (BRAFi) resistant melanoma according to results generated by researchers from University of Miami , Taipei Medical University, and MD Anderson Cancer Center. (prnewswire.com)
  • THE FIRST-GENERATION reversible proteasome inhibitor bortezomib (Velcade) has been extensively tested in both salvage and early-disease settings in combination with steroids vs steroids alone, and then as part of doublet and triplet combinations. (ascopost.com)
  • All patients were required to receive antiviral therapy and a proton pump inhibitor. (ascopost.com)
  • Phase II trials with lopinavir/ritonavir (LPV/r) for salvage therapy were performed mostly in non-nucleoside RT inhibitor (NNRTI)-naïve patients. (i-base.info)
  • Although improved responses have been achieved through intensive chemotherapy in newly diagnosed patients with aggressive ATL, most patients suffer from relapse or disease recurrence, and an effective salvage therapy, especially for candidates for allogeneic hematopoietic stem cell transplantation (allo-HSCT), is yet to be established. (springer.com)
  • At the 2018 ASH Annual Meeting, investigators presented results from ReLApsE, the first randomized clinical trial comparing reinduction, salvage AHCT, and lenalidomide maintenance therapy with continuous lenalidomide-dexamethasone (Rd) therapy in this setting. (ashclinicalnews.org)
  • For patients with multiple myeloma (MM) that has relapsed following autologous hematopoietic cell transplantation (AHCT), a standard salvage therapy approach involves high-dose chemotherapy and AHCT. (ashclinicalnews.org)
  • Clinical trials and experimental medications are also considered salvage therapy. (healthline.com)
  • Many questions relating to salvage and HDC therapy for patients with Hodgkin lymphoma need to be addressed and are the subject of ongoing clinical trials. (medscape.com)
  • Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy. (nature.com)
  • These findings also apply to tumor samples from patients who failed BRAF and MEK inhibitors, making ADI-PEG 20 a potential salvage therapy for BR patients. (prnewswire.com)
  • Conclusions: Intermittent negative pressure wound therapy combined with a mesh incision can be a safe option to rescue perforator flaps with venous congestion. (researchsquare.com)
  • We report the use of meropenem-vaborbactam as salvage therapy for ceftazidime-avibactam-resistant KPC-producing K. pneumoniae infection in a liver transplant recipient. (asm.org)
  • HCV infection is curable, and all Australians living with HCV should be considered for antiviral therapy. (mja.com.au)
  • The PBS listing allows these therapies to be prescribed by specialists experienced in treating chronic HCV infection or by general practitioners in consultation with one of these specialists. (mja.com.au)
  • The recent International Congress on Drug Therapy in HIV Infection (HIV Glasgow) featured trials of several HIV drugs with modes of action different from the usual classes. (aidsmap.com)
  • VNS Therapy (Vagus Nerve Stimulation): Vagal nerve stimulator infection: a lead-salvage protocol. (blogspot.com)
  • Vagal nerve stimulator infection: a lead-salvage protocol. (blogspot.com)
  • Vagal nerve stimulator lead salvage is a safe and potentially advantageous strategy in the management of VNS-related infection. (blogspot.com)
  • Extensive histological sampling following focal therapy of clinically significant prostate cancer with high-intensity focused ultrasound. (bioportfolio.com)
  • Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). (sigmaaldrich.com)
  • The hypomethylating agents (HAs), azacitidine and decitabine, have emerged as an alternative to initial and salvage therapy in patients with acute myeloid leukemia (AML). (sigmaaldrich.com)
  • Moore AS, Kearns PR, Knapper S et al (2013) Novel therapies for children with acute myeloid leukemia. (springermedizin.de)
  • The relative selectiveness of INO in accomplishing this effect makes it an attractive drug to administer as salvage therapy in patients with acute right ventricular failure secondary to pulmonary embolism. (nih.gov)
  • Conclusion: While third-line salvage therapy may be efficacious in achieving short-term clinical response/remission, there remains a significant risk of colectomy and adverse events. (harvard.edu)
  • This possibility is reflected by the finding that virologic failure occurs in some patients despite genotypic tests showing that the virus is sensitive before salvage therapy is initiated. (natap.org)
  • However, despite the brilliant results obtained with this drug, more than 30% of patients discontinue therapy in long-term due to several reasons, including failure and/or intolerance. (mjhid.org)
  • The primary purpose of this study is to evaluate the feasibility and safety of MRI-guided focal laser ablation (Laser-Induced Interstitial Thermal Therapy, LITT) to treat low-risk native p. (bioportfolio.com)
  • To evaluate the cancer control for prostate cancer patients treated with focal therapy. (bioportfolio.com)
  • Ahmed HU, Pendse D, Illing R, Allen C, van der Meulen JH, Emberton M (2007) Will focal therapy become a standard of care for men with localized prostate cancer? (springer.com)
  • Salvage therapy drugs or drug combinations have, in general, much more severe side effects than the standard line of therapy. (wikipedia.org)
  • However, that doesn't mean that salvage therapy can't be used to achieve remission or eliminate severe symptoms. (healthline.com)
  • Colon salvage therapy for acute severe colitis: cyclosporine or infliximab? (biomedsearch.com)
  • 4-7 We report a case of severe UC with successive salvage therapy guided by serum IFX level. (gi.org)
  • High Dose Sildenafil Citrate As A Salvage Therapy For Severe Erectile Dysfunction. (cicinvestments.com)