Cornified Envelope Proline-Rich Proteins
Proline
beta-Keratins
Proline-Rich Protein Domains
Molecular Sequence Data
Amino Acid Sequence
Proline Oxidase
LIM Domain Proteins
src Homology Domains
Antigens, Protozoan
Malaria, Falciparum
Plasmodium falciparum
Different type 1 fimbrial genes and tropisms of commensal and potentially pathogenic Actinomyces spp. with different salivary acidic proline-rich protein and statherin ligand specificities. (1/27)
Actinomyces spp. exhibit type 1 fimbria-mediated adhesion to salivary acidic proline-rich proteins (PRPs) and statherin ligands. Actinomyces spp. with different animal and tissue origins belong to three major adhesion types as relates to ligand specificity and type 1 fimbria genes. (i) In preferential acidic-PRP binding, strains of Actinomyces naeslundii genospecies 1 and 2 from human and monkey mouths displayed at least three ligand specificities characterized by preferential acidic-PRP binding. Slot blot DNA hybridization showed seven highly conserved type 1 fimbria genes (orf1- to -6 and fimP) in genospecies 1 and 2 strains, except that orf5 and orf3 were divergent in genospecies 1. (ii) In preferential statherin binding, oral Actinomyces viscosus strains of rat and hamster origin (and strain 19246 from a human case of actinomycosis) bound statherin preferentially. DNA hybridization and characterization of the type 1 fimbria genes from strain 19246 revealed a homologous gene cluster of four open reading frames (orfA to -C and fimP). Bioinformatics suggested sortase (orfB, orf4, and part of orf5), prepilin peptidase (orfC and orf6), fimbria subunit (fimP), and usher- and autotransporter-like (orfA and orf1 to -3) functions. Those gene regions corresponding to orf3 and orf5 were divergent, those corresponding to orf2, orf1, and fimP were moderately conserved, and those corresponding to orf4 and orf6 were highly conserved. Restriction fragment length polymorphism analyses using a fimP probe separated human and monkey and rat and hamster strains into phylogenetically different groups. (iii) In statherin-specific binding, strains of A. naeslundii genospecies 1 from septic and other human infections displayed a low-avidity binding to statherin. Only the orf4 and orf6 gene regions were highly conserved. Finally, rat saliva devoid of statherin bound bacterial strains avidly irrespective of ligand specificity, and specific antisera detected either type 1, type 2, or both types of fimbria on the investigated Actinomyces strains. (+info)The regulation of ER-alpha transcription by pRb2/p130 in breast cancer. (2/27)
Breast carcinoma is the most common form of neoplasia in women of the Western world, and the mortality from this disease in women is second only to that of lung cancer, with a means incidence of 10%. Although, several studies have indicated that the development of this fairly heterogeneous disease depends on a great many environmental, socio-economic, hormonal and genetic factors, the pathogenesis of breast cancer remains poorly understood. ER-alpha (estrogen-receptor alpha) and its ligand (17beta-estradiol) play a crucial role in normal breast development and have also been linked to mammary carcinogenesis and clinical outcome in breast cancer patients. The estrogen signaling regulates the growth of some breast tumors, and antiestrogen therapies can effectively block this growth signaling resulting in tumor suppression. However, most tumors eventually develop antiestrogen resistance, and antiestrogen are mostly ineffective in patience with advanced disease. Although several studies have been proposed that epigenetic events could be involved in ER-alpha silencing the mechanisms regulating ER-alpha transcription are poorly understood. Our studies suggested that pRb2/p130-complexes bind to the ER-alpha promoter and could be involved in the transcriptional regulation of the ER-alpha gene by altering chromatin structure and DNA methylation pattern. (+info)Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. (3/27)
Cells of several strains of Streptococcus gordonii attached in much higher numbers to experimental pellicles formed from samples of submandibular or parotid saliva on hydroxyapatite (HA) beads than to buffer controls. The nature of the salivary components responsible were investigated by preparing experimental pellicles from chromatographic fractions of submandibular saliva obtained from Trisacryl GF 2000M columns. Adhesion of S. gordonii Blackburn was promoted by two groups of fractions. The adhesion-promoting activity in the first group of fractions was associated with the family of acidic proline-rich proteins (PRPs), while that of the second group is as yet unidentified. Experimental pellicles prepared by treating HA with 2 micrograms of pure 150-amino-acid-residue PRPs (PRP-1, PRP-2, and PIF-s) promoted adhesion of S. gordonii Blackburn cells to an extent comparable to that obtained with unfractionated saliva. However, pellicles prepared from a 106-residue PRP (PRP-3) were significantly less effective, and those prepared from the amino-terminal tryptic peptide (residues 1 to 30) of the PRP and the salivary phosphoprotein statherin were completely ineffective in promoting adhesion. Although adhesion of several strains of S. gordonii was promoted by adsorbed PRP-1, the adhesion of several strains of Streptococcus sanguis or Streptococcus oralis was either not affected or only weakly enhanced by this protein. S. gordonii cells bound avidly to PRPs adsorbed onto HA beads, but the streptococci did not appear to bind PRPs in solution, since concentrations of PRP as high as 200 micrograms/ml did not inhibit binding of bacterial cells to pellicles prepared from pure PRP. S. gordonii cells also attached well to PRP or a synthetic decapeptide representing residues 142 to 150 of the PRP when the peptide was linked to agarose beads. Studies with a series of synthetic decapeptides indicated that the minimal segment of PRP which promoted high levels of S. gordonii adhesion was the carboxy-terminal dipeptide Pro-Gln (residues 149 and 150). (+info)Concentration and fate of histatins and acidic proline-rich proteins in the oral environment. (4/27)
(+info)Small molecular weight proteins/peptides present in the in vivo formed human acquired enamel pellicle. (5/27)
(+info)Protein expression in salivary glands of rats with streptozotocin diabetes. (6/27)
(+info)Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. (7/27)
(+info)Proline-rich salivary proteins have extended conformations. (8/27)
(+info)Cornified envelope (CE) proline-rich proteins are a group of structural proteins that play an essential role in the formation and integrity of the cornified envelope, which is a tough, protective layer that surrounds the outermost layer of the skin (the stratum corneum). These proteins are rich in the amino acid proline and help to provide mechanical strength and resistance to friction and chemical stressors. They are important for maintaining the barrier function of the skin and preventing water loss. Some examples of CE proline-rich proteins include involucrin, loricrin, and hornerin.
Proline is an organic compound that is classified as a non-essential amino acid, meaning it can be produced by the human body and does not need to be obtained through the diet. It is encoded in the genetic code as the codon CCU, CCC, CCA, or CCG. Proline is a cyclic amino acid, containing an unusual secondary amine group, which forms a ring structure with its carboxyl group.
In proteins, proline acts as a structural helix breaker, disrupting the alpha-helix structure and leading to the formation of turns and bends in the protein chain. This property is important for the proper folding and function of many proteins. Proline also plays a role in the stability of collagen, a major structural protein found in connective tissues such as tendons, ligaments, and skin.
In addition to its role in protein structure, proline has been implicated in various cellular processes, including signal transduction, apoptosis, and oxidative stress response. It is also a precursor for the synthesis of other biologically important compounds such as hydroxyproline, which is found in collagen and elastin, and glutamate, an excitatory neurotransmitter in the brain.
Beta-keratins are a type of keratin proteins that are mainly found in the cells of reptiles, birds, and some mammals such as marsupials. These proteins make up the scales, feathers, claws, beaks, and other hard structures of these animals. Beta-keratins have a different molecular structure compared to alpha-keratins, which are the predominant type of keratins found in mammalian skin, hair, and nails.
Proline-rich protein domains are segments within proteins that contain an unusually high concentration of the amino acid proline. These domains are often involved in mediating protein-protein interactions and can play a role in various cellular processes, such as signal transduction, gene regulation, and protein folding. They are also commonly found in extracellular matrix proteins and may be involved in cell adhesion and migration. The unique chemical properties of proline, including its ability to form rigid structures and disrupt alpha-helices, contribute to the functional specificity of these domains.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.
Proline oxidase is an enzyme that catalyzes the chemical reaction of oxidizing proline to Δ^1^-pyrroline-5-carboxylate (P5C) and hydrogen peroxide (H2O2). The reaction is a part of the catabolic pathway for proline utilization in some organisms.
The systematic name for this enzyme is L-proline:oxygen oxidoreductase (deaminating, decarboxylating). It belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as an acceptor. This enzyme participates in arginine and proline metabolism.
LIM domain proteins are a group of transcription factors that contain LIM domains, which are cysteine-rich zinc-binding motifs. These proteins play crucial roles in various cellular processes such as gene regulation, cell proliferation, differentiation, and migration. They are involved in the development and functioning of several organ systems including the nervous system, cardiovascular system, and musculoskeletal system. LIM domain proteins can interact with other proteins and DNA to regulate gene expression and have been implicated in various diseases such as cancer and neurological disorders.
SRC homology domains, often abbreviated as SH domains, are conserved protein modules that were first identified in the SRC family of non-receptor tyrosine kinases. These domains are involved in various intracellular signaling processes and mediate protein-protein interactions. There are several types of SH domains, including:
1. SH2 domain: This domain is approximately 100 amino acids long and binds to specific phosphotyrosine-containing motifs in other proteins, thereby mediating signal transduction.
2. SH3 domain: This domain is about 60 amino acids long and recognizes proline-rich sequences in target proteins, playing a role in protein-protein interactions and intracellular signaling.
3. SH1 domain: Also known as the tyrosine kinase catalytic domain, this region contains the active site responsible for transferring a phosphate group from ATP to specific tyrosine residues on target proteins.
4. SH4 domain: This domain is present in some SRC family members and serves as a membrane-targeting module by interacting with lipids or transmembrane proteins.
These SH domains allow SRC kinases and other proteins containing them to participate in complex signaling networks that regulate various cellular processes, such as proliferation, differentiation, survival, and migration.
Antigens are substances (usually proteins) found on the surface of cells, or viruses, that can be recognized by the immune system and stimulate an immune response. In the context of protozoa, antigens refer to the specific proteins or other molecules found on the surface of these single-celled organisms that can trigger an immune response in a host organism.
Protozoa are a group of microscopic eukaryotic organisms that include a diverse range of species, some of which can cause diseases in humans and animals. When a protozoan infects a host, the host's immune system recognizes the protozoan antigens as foreign and mounts an immune response to eliminate the infection. This response involves the activation of various types of immune cells, such as T-cells and B-cells, which recognize and target the protozoan antigens.
Understanding the nature of protozoan antigens is important for developing vaccines and other immunotherapies to prevent or treat protozoan infections. For example, researchers have identified specific antigens on the surface of the malaria parasite that are recognized by the human immune system and have used this information to develop vaccine candidates. However, many protozoan infections remain difficult to prevent or treat, and further research is needed to identify new targets for vaccines and therapies.
Malaria, Falciparum is defined as a severe and often fatal form of malaria caused by the parasite Plasmodium falciparum. It is transmitted to humans through the bites of infected Anopheles mosquitoes. This type of malaria is characterized by high fever, chills, headache, muscle and joint pain, and vomiting. If left untreated, it can cause severe anemia, kidney failure, seizures, coma, and even death. It is a major public health problem in many tropical and subtropical regions of the world, particularly in Africa.
I'm sorry for any confusion, but "Protozoan Proteins" is not a specific medical or scientific term. Protozoa are single-celled eukaryotic organisms, and proteins are large biological molecules consisting of one or more chains of amino acid residues. Therefore, "Protozoan Proteins" generally refers to the various types of proteins found in protozoa.
However, if you're looking for information about proteins specific to certain protozoan parasites with medical relevance (such as Plasmodium falciparum, which causes malaria), I would be happy to help! Please provide more context or specify the particular protozoan of interest.
'Plasmodium falciparum' is a specific species of protozoan parasite that causes malaria in humans. It is transmitted through the bites of infected female Anopheles mosquitoes and has a complex life cycle involving both human and mosquito hosts.
In the human host, the parasites infect red blood cells, where they multiply and cause damage, leading to symptoms such as fever, chills, anemia, and in severe cases, organ failure and death. 'Plasmodium falciparum' malaria is often more severe and life-threatening than other forms of malaria caused by different Plasmodium species. It is a major public health concern, particularly in tropical and subtropical regions of the world where access to prevention, diagnosis, and treatment remains limited.
A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.
Proline-rich protein 30
PRB1
PRB4
Proline-rich protein haeiii subfamily 2
Marta Bunster
PRB3
Proline rich protein
Salivary gland
PRH1
Dental pellicle
Oviduct-specific glycoprotein
STATH
Robert Baratz
Dental plaque
Proline-rich protein 21
Saliva
PELP-1
FDC-SP
IFFO1
NEDD4
TMEM171
Histatin 1
NUMB (gene)
Chromosome 12
INAVA
STIM2
C19orf67
Polistes annularis
SLC46A3
Chromosome 19
LOC120101003 (basic salivary proline-rich protein 1-like) - Rat Genome Database
Proline-rich protein 30 - Wikipedia
The Human Salivary Proteome: A Critical Overview
Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2 - PubMed
Biomarkers Search
Mucin dynamics and enteric pathogens | Nature Reviews Microbiology
NIH Guide: MULTIDISCIPLINARY APPROACH FOR RESEARCH ON ORAL COMPLICATIONS OF HIV INFECTION
DeCS
MeSH Browser
MeSH Browser
Pharos : Target Details - PRB1
Pesquisa | Portal Regional da BVS
Polyphenols and oral health
c-Myb Polyclonal Antibody - Abbkine - Antibodies, proteins, biochemicals, assay kits for life science research
Naviga IRIS
Actinomyces Odontolyticus Bacteremia - Volume 9, Number 12-December 2003 - Emerging Infectious Diseases journal - CDC
DeCS 2009 - Novos termos
Endothelial cell cytotoxicity of cotton bracts tannin and aqueous cotton bracts extract: tannin is the predominant cytotoxin...
May 2016 - APOPTOSIS AND NECROSIS
NEW (2009) MESH HEADINGS WITH SCOPE NOTES (UNIT RECORD FORMAT; 10/20/2008
Correlating wine astringency with physical measures - current knowledge and future directions - Science & Wine
Antigen I/II (AgI/II) has been widely studied as a candidate vaccine | Small-molecule inhibitors of mTOR signalling pathway
Molecular Vision: Androgen regulation of gene expression in human meibomian gland and conjunctival epithelial cells
DeCS 2009 - New terms
DeCS 2009 - New terms
Gendoo
Human INa(Internexin Neuronal Intermediate Filament Protein Alpha) ELISA Kit - Jemsec International NGS
Human HVCN1(Hydrogen Voltage Gated Channel Protein 1) ELISA Kit - LipidX
Human DAPK1(Death Associated Protein Kinase 1) ELISA Kit - Enzyme-linked Immunosorbent Assay Kits
Glands9
- The presence of mononuclear cell aggregates around the ducts and acini of salivary glands results in functional and structural alterations at the level of these glands and impairs their secretory function. (intechopen.com)
- The salivary glands of SS patients are characterized by chronic inflammation with the presence of lymphocytic infiltrates located around the striated ducts. (intechopen.com)
- The presence of foci in labial salivary glands is a hallmark of SS, and their histopathologic analysis is an important item in the diagnosis and classification. (intechopen.com)
- The authors present the main ultrasonic signs of SS major salivary glands and perspectives of the usage of salivary gland ultrasonic examination in the diagnosis and monitoring of SS. (intechopen.com)
- For example, in 1869 a physician wrote that chewing gum would "exhaust the salivary glands and cause the intestines to stick together. (dentistrytoday.com)
- In humans, saliva is generated by 3 pairs of major and numerous minor salivary glands. (dentistrytoday.com)
- The major salivary glands produce 93% of all saliva. (dentistrytoday.com)
- 4 The salivary glands are under the control of the autonomic nervous system and respond to hormonal influences. (dentistrytoday.com)
- An issue with your salivary glands or disorders might cause chronic dry mouth. (healthysupplementsguide.com)
Saliva13
- Description: A sandwich quantitative ELISA assay kit for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in samples from saliva or other biological fluids. (glideruniversity.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in saliva and other biological fluids. (glideruniversity.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in samples from saliva and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
- In the present study, we show that the heterogeneous mixture of glycoforms of the basic salivary proline-rich protein 3M, encoded by PRB3-M locus, is a major component of the acidic soluble fraction of human whole saliva in the first years of life. (unicatt.it)
- Saliva in SS is characterized by the increased concentration of lactoferrin, potassium and cystatin C and the decreased concentration of amylase, carbonic anhydrase, mucins, histatines, IgA, statherins, proline-rich proteins, and the loss of salivary buffer properties. (intechopen.com)
- Aside from lubricating the tissues, saliva helps maintain a pH environment that promotes tooth remineralization via deposition of ionic minerals available in solution and serves an antimicrobial function as a result of the immunoglobulins and proteins present in the fluid. (dentistrytoday.com)
- Following ingestion of a dietary sugar, the stimulated production of saliva ceases after the sugar clears the mouth, and salivary output returns to a resting state within a short time.5,6 The tooth is most susceptible to demineralization and white spot production during the period of lowered pH. (dentistrytoday.com)
- The importance of saliva is clearly observed after salivary flow is reduced. (dentistrytoday.com)
- Some of these proteins increased the binding of S. gordonii to saliva-coated brackets. (snu.ac.kr)
- The search for reliable salivary biomarkers for early detection of OSCC has developed rapidly, spurred on by the fact that collecting saliva is relatively easy and non-invasive, compared to the drawing of blood. (springeropen.com)
- A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal. (lookformedical.com)
- Previous research with rats demonstrated that when the animals were fed a diet of bitter food, the expression of these flavour proteins in the rodents' saliva was altered. (sciencealert.com)
- Changes in the makeup of their saliva were also taking place, with Running observing that the levels of proline-rich proteins - which can bind to the bitter and/or astringent compounds in the milk - was increasing in the participants' saliva. (sciencealert.com)
Mucin4
- Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
- MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
- The results showed that low-molecular-weight mucin, alpha-amylase, secretory IgA, acidic proline-rich proteins, and cystatins adhered to all kinds of brackets, though the amino acid composition of pellicles differed between bracket types. (snu.ac.kr)
- Definition Dental Plaque "is a specific but highly variable structural entity, resulting from sequential colonization of microorganisms on tooth surfaces, restorations & other parts of oral cavity, composed of salivary components like mucin, desquamated epithelial cells, debris & microorganisms, all embedded in extracellular gelatinous matrix. (medicpresents.com)
Secretory2
- Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. (metabiom.org)
- The ribonucleotide-protein complex signal recognition particle (SRP) is conserved in all three domains of life and delivers membrane and secretory proteins to the cyoplasmic membrane or endoplasmic reticulum. (ufl.edu)
Peptides2
- Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body. (psyclopeptide.com)
- These bacteria or yeast secrete their proteolytic enzymes in due course to release peptides from the proteins. (psyclopeptide.com)
Gland3
- A biopsy can be taken from either the labial or the parotid salivary gland, but currently according to the diagnostic criteria, only labial salivary gland biopsy (LSGB) is recommended to confirm the diagnosis of SS. (intechopen.com)
- The authors present their own experience and recommendations in taking labial salivary gland biopsy, the main surgical approaches, and the main limitations for this diagnostic method and describe the possibilities and principles of histopathological examination in SS. (intechopen.com)
- A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w. (shengsci.com)
Glycoproteins3
- This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. (cancerindex.org)
- Organic Component Organic constituents : polysaccharides, proteins, glycoproteins, and lipid material Polysaccharides produced by bacteria-Dextran: predominant form Albumin: originating from crevicular fluid Lipid material: debris from the membranes of disrupted bacterial and host cells and possibly food debris. (medicpresents.com)
- Composed of proteins and glycoproteins. (medicpresents.com)
Constituents2
- From the late 1990s until the present, more than 40 research studies have been published and more than 100 different salivary constituents have been suggested as potential OSCC salivary biomarkers (see Table 1 ). (springeropen.com)
- and studies of intra- and inter-molecular protein-protein interactions relevant for bacterial protein stability, function and adhesive interactions with host constituents. (ufl.edu)
Cystatins1
- Due to the presence of histatins (proline-rich proteins including cystatins and statherin), calcium and phosphate are maintained in supersaturation and are available for remineralization of tooth structure. (dentistrytoday.com)
Gene7
- Proline-rich protein 30 (PRR30 or C2orf53) is a protein in humans that is encoded for by the PRR30 gene. (wikipedia.org)
- This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
- What does this gene/protein do? (cancerindex.org)
- The salivary MUC7 gene provides an opportunity for studying such variation, as it harbors copy number variable subexonic repeat sequences that encode for densely O-glycosylated domains (PTS-repeats) with microbe-binding properties. (nature.com)
- Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. (shengsci.com)
- A gene discovery approach is being used to identify global changes in protein expression that occur when adhesin P1 is engaged with a physiological binding partner. (ufl.edu)
- Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Serine2
- Second, the subexonic repeats of MUC7 code for densely O-glycosylated proline-, threonine-, and serine-rich (PTS) tandem repeat domains. (nature.com)
- Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. (lookformedical.com)
Bacteria2
- Protein is hydrolyzed by culturing bacteria or yeast on the protein substrates. (psyclopeptide.com)
- Streptococci also encode two homologs of the evolutionary conserved YidC/Oxa/Alb family of membrane-associated chaperones expressed by bacteria, mitochonidria, and chloroplasts that mediate and contribute to the insertion of membrane proteins and multi subunit complexes, including components of the F1F0 ATP synthase. (ufl.edu)
Alanine2
- We have characterized multiple conformational epitopes recognized by monoclonal antibodies against the P1 adhesin of S. mutans and demonstrated that the an intra-molecular interaction between the amino-terminal alanine-rich repeat and central proline-rich repeat domains is necessary for the structural integrity, surface localization and function of the molecule. (ufl.edu)
- It's also worth noting that Chlorella Vulgaris extract is high in amino acids like glycine, proline, lysine, and alanine, which are necessary protein building blocks that make up each collagen unit. (healthysupplementsguide.com)
Mucins1
- Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
Gingival1
- Natural cleansing mechanism: Gingival crevicular fluid & salivary flow Cleansing effect of mastication and tongue movement Rapid turnover rate of intraoral epithelial cells Host defence mechanisms like langerhans cells. (medicpresents.com)
Statherin1
- A. naeslundii, which was formerly referred to as genospecies 1 , and A. oris bind to PRPs and statherin, a phosphate-containing protein in salivary components [ 1 ]. (biomedcentral.com)
Functionally1
- The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. (shengsci.com)
Compounds2
- consistently, it could be significantly enhanced by supplementation with either polyphenol-rich extracts or individual compounds. (docksci.com)
- It's early days, but the researchers want to find out more about what's going on here, looking at what kinds of particular compounds in food are eliciting changes in our salivary proteins, and investigating how long it takes for our taste buds to adapt to new, disliked tastes. (sciencealert.com)
High molecular weight1
- Also, in collaboration with Dr. Champion Deivanayagam of the Center for Biophysical Sciences and Engineering at the University of Alabama we are utilizing X-ray crystallography in conjunction with protein interaction methodologies to define the structure of P1 and to identify the binding motif responsible for its interaction with the high molecular weight gp340 salivary agglutinin ligand. (ufl.edu)
Human16
- Description: A sandwich ELISA kit for detection of Basic Salivary Proline Rich Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
- PRR30 Splice Pattern Human protein PRR30 consists of 412 amino acid residues. (wikipedia.org)
- IntAct predicts that PRR30 interacts with Human Testis Protein 37 or TEX37, Cystiene Rich Tail Protein 1 (CYSRT1), and Keratin Associated Protein 6-2 (KRTAP6-2). (wikipedia.org)
- Other Proline-Rich Proteins have been shown to have an affinity for binding calcium across different tissues in the human body. (wikipedia.org)
- N- and O-linked glycosylation site profiling of the human basic salivary proline-rich protein 3M. (unicatt.it)
- The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
- Human PRB1 Protein (raised in Insect Cells) purified by multi-step, protein-specific process to ensure crystallization grade. (antibodies-online.com)
- Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among all major human cancers. (springeropen.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Jagged 1 Protein (JAG1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (kits-elisa.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Jagged 1 Protein (JAG1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
- Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
- Description: A sandwich ELISA kit for detection of GRB2 Related Adaptor Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
- Description: A sandwich ELISA kit for detection of High Mobility Group AT Hook Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human High Mobility Group AT Hook Protein 1 (HMGA1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human G Protein Coupled Receptor 120 (GPR120) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
- Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
Carbohydrate2
- The need for protection afforded by salivary buffers is highest after carbohydrate consumption. (dentistrytoday.com)
- 2015). Determining the composition of protein, carbohydrate, moisture, fat, and ash in raw EBN is essential for various purposes, including the hydrolysis process for the extraction of its valuable components. (researchgate.net)
Sequences2
- A pure form of proteolytic enzyme is used to hydrolyze the protein to produce short peptide sequences. (psyclopeptide.com)
- Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)
Specificity1
- We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
Transcription Factors1
- These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
Mediate1
- The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
Aggregates1
- Incubation of #Porphyromonas gingivalis , a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions. (metabiom.org)
Component1
- We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Detection3
- By raising the awareness of these issues on the part of both researchers and clinicians, it is hoped that reliable, specific and sensitive salivary biomarkers may be found soon-and not only biomarkers for early OSCC detection but also for detecting other types of cancers or even for monitoring non-cancerous disease activity. (springeropen.com)
- Addressing these issues not only will serve to accelerate progress toward finding reliable salivary biomarkers for early OSCC detection, but also should have a positive effect on the search of reliable salivary biomarkers for other types of cancer detection or even for monitoring non-cancerous disease activity. (springeropen.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
Major2
- Our results establish MUC7 as a major player in salivary adaptation, likely as a response to diverse pathogenic exposure in primates. (nature.com)
- This review article will provide an up-to-date list of potential OSCC salivary biomarkers, as of the fall of 2013, and will focus on some emerging issues/challenges that seem to be major roadblocks on the way to bringing reliable salivary biomarkers into actual clinical use. (springeropen.com)
Regulator2
- Using affinity chromatography coupled to multidimensional protein identification technology (MudPIT), DEAF-1 was identified as a candidate regulator. (sdbonline.org)
- To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
Homo2
- Homo est devenu un consommateur régulier de produits carnés en complément des végétaux et d'insectes. (ocl-journal.org)
- Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)
Basic1
- Whatever your level of training, you need to ensure your basic nutrition provides adequate calories, vitamins, minerals, protein and water, you may then consider specific supplements. (newimage.asia)
Kinase6
- After immunoprecipitation of Akt, the kinase reaction was performed using the instructions provided by the manufacturer with glycogen synthase kinase (GSK)-3 fusion protein as an exogenous substrate. (srcinhibitors.com)
- Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
- Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. (jci.org)
- Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
- This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
- In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. (jci.org)
Found3
- Collectively, salivary pellicles were found to play a significant role in the initial adhesion of oral streptococci to orthodontic brackets. (snu.ac.kr)
- Proteins found in any species of fungus. (lookformedical.com)
- It was also found that both nests share a common 77 KDa protein that has properties similar to those of the ovotransferrin protein in eggs. (researchgate.net)
Humans1
- Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota. (metabiom.org)
Receptor1
- Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. (shengsci.com)
Oral1
- In the oral cavity, polyphenols (particularly flavanols and proanthocyanidins), partially released from the food matrix, are able to interact with salivary proteins rich in proline. (docksci.com)
Flow1
- An unstimulated salivary flow rate of 0.1 ml/min in sialometry gives a score of 1 to the weighted sum of 5 items according to the current EULAR/ACR criteria. (intechopen.com)
Rapid1
- A modified xanthoproteic nitric acid test for proteins proved to be a rapid, and simple test to detect adulteration in both whole and finely ground nests, and would be suitable in the field where analytical facilities are not readily available. (researchgate.net)
Function2
- Unstructured proteins like PRR30 are highly variable in function. (wikipedia.org)
- Consistent with a cell-cycle regulatory function, CYLD localizes to microtubules in interphase and the midbody during telophase CYLD 's protein levels decrease as cells exit from mitosis. (medscape.com)
Group1
- by the reduction of the available -OH group interacting with salivary proteins, the direct eliciting capacity of anthocyanins is far from clear. (oeno-one.eu)
Expression3
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- In the unlikely event that the protein cannot be expressed or purified we do not charge anything (other companies might charge you for any performed steps in the expression process for custom-made proteins, e.g. fees might apply for the expression plasmid, the first expression experiments or purification optimization). (antibodies-online.com)
- If we can change the expression of these proteins, maybe we can make the 'bad' flavours like bitterness and astringency weaker," Running explains . (sciencealert.com)
Tissue1
- Recent reports indicate that the inflammatory response triggered by tissue damage is mediated by a multiple-protein complex called the inflammasome. (bvsalud.org)