A family of low molcular-weight proteins that contain PROLINE-RICH PROTEIN DOMAINS. Members of this family play a role in the formation of an insoluble cornified envelope beneath the plasma membrane of stratified squamous epithelial cells.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Keratins that form into a beta-pleated sheet structure. They are principle constituents of the corneous material of the carapace and plastron of turtles, the epidermis of snakes and the feathers of birds.
Protein domains that are enriched in PROLINE. The cyclical nature of proline causes the peptide bonds it forms to have a limited degree of conformational mobility. Therefore the presence of multiple prolines in close proximity to each other can convey a distinct conformational arrangement to a peptide chain.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrroline-5-carboxylic acid in the presence of oxygen and water. The action is not reversible. The specific activity of proline oxidase increases with age. EC 1.5.3.-.
A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Proteins found in any species of protozoan.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Different type 1 fimbrial genes and tropisms of commensal and potentially pathogenic Actinomyces spp. with different salivary acidic proline-rich protein and statherin ligand specificities. (1/27)

Actinomyces spp. exhibit type 1 fimbria-mediated adhesion to salivary acidic proline-rich proteins (PRPs) and statherin ligands. Actinomyces spp. with different animal and tissue origins belong to three major adhesion types as relates to ligand specificity and type 1 fimbria genes. (i) In preferential acidic-PRP binding, strains of Actinomyces naeslundii genospecies 1 and 2 from human and monkey mouths displayed at least three ligand specificities characterized by preferential acidic-PRP binding. Slot blot DNA hybridization showed seven highly conserved type 1 fimbria genes (orf1- to -6 and fimP) in genospecies 1 and 2 strains, except that orf5 and orf3 were divergent in genospecies 1. (ii) In preferential statherin binding, oral Actinomyces viscosus strains of rat and hamster origin (and strain 19246 from a human case of actinomycosis) bound statherin preferentially. DNA hybridization and characterization of the type 1 fimbria genes from strain 19246 revealed a homologous gene cluster of four open reading frames (orfA to -C and fimP). Bioinformatics suggested sortase (orfB, orf4, and part of orf5), prepilin peptidase (orfC and orf6), fimbria subunit (fimP), and usher- and autotransporter-like (orfA and orf1 to -3) functions. Those gene regions corresponding to orf3 and orf5 were divergent, those corresponding to orf2, orf1, and fimP were moderately conserved, and those corresponding to orf4 and orf6 were highly conserved. Restriction fragment length polymorphism analyses using a fimP probe separated human and monkey and rat and hamster strains into phylogenetically different groups. (iii) In statherin-specific binding, strains of A. naeslundii genospecies 1 from septic and other human infections displayed a low-avidity binding to statherin. Only the orf4 and orf6 gene regions were highly conserved. Finally, rat saliva devoid of statherin bound bacterial strains avidly irrespective of ligand specificity, and specific antisera detected either type 1, type 2, or both types of fimbria on the investigated Actinomyces strains.  (+info)

The regulation of ER-alpha transcription by pRb2/p130 in breast cancer. (2/27)

Breast carcinoma is the most common form of neoplasia in women of the Western world, and the mortality from this disease in women is second only to that of lung cancer, with a means incidence of 10%. Although, several studies have indicated that the development of this fairly heterogeneous disease depends on a great many environmental, socio-economic, hormonal and genetic factors, the pathogenesis of breast cancer remains poorly understood. ER-alpha (estrogen-receptor alpha) and its ligand (17beta-estradiol) play a crucial role in normal breast development and have also been linked to mammary carcinogenesis and clinical outcome in breast cancer patients. The estrogen signaling regulates the growth of some breast tumors, and antiestrogen therapies can effectively block this growth signaling resulting in tumor suppression. However, most tumors eventually develop antiestrogen resistance, and antiestrogen are mostly ineffective in patience with advanced disease. Although several studies have been proposed that epigenetic events could be involved in ER-alpha silencing the mechanisms regulating ER-alpha transcription are poorly understood. Our studies suggested that pRb2/p130-complexes bind to the ER-alpha promoter and could be involved in the transcriptional regulation of the ER-alpha gene by altering chromatin structure and DNA methylation pattern.  (+info)

Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. (3/27)

Cells of several strains of Streptococcus gordonii attached in much higher numbers to experimental pellicles formed from samples of submandibular or parotid saliva on hydroxyapatite (HA) beads than to buffer controls. The nature of the salivary components responsible were investigated by preparing experimental pellicles from chromatographic fractions of submandibular saliva obtained from Trisacryl GF 2000M columns. Adhesion of S. gordonii Blackburn was promoted by two groups of fractions. The adhesion-promoting activity in the first group of fractions was associated with the family of acidic proline-rich proteins (PRPs), while that of the second group is as yet unidentified. Experimental pellicles prepared by treating HA with 2 micrograms of pure 150-amino-acid-residue PRPs (PRP-1, PRP-2, and PIF-s) promoted adhesion of S. gordonii Blackburn cells to an extent comparable to that obtained with unfractionated saliva. However, pellicles prepared from a 106-residue PRP (PRP-3) were significantly less effective, and those prepared from the amino-terminal tryptic peptide (residues 1 to 30) of the PRP and the salivary phosphoprotein statherin were completely ineffective in promoting adhesion. Although adhesion of several strains of S. gordonii was promoted by adsorbed PRP-1, the adhesion of several strains of Streptococcus sanguis or Streptococcus oralis was either not affected or only weakly enhanced by this protein. S. gordonii cells bound avidly to PRPs adsorbed onto HA beads, but the streptococci did not appear to bind PRPs in solution, since concentrations of PRP as high as 200 micrograms/ml did not inhibit binding of bacterial cells to pellicles prepared from pure PRP. S. gordonii cells also attached well to PRP or a synthetic decapeptide representing residues 142 to 150 of the PRP when the peptide was linked to agarose beads. Studies with a series of synthetic decapeptides indicated that the minimal segment of PRP which promoted high levels of S. gordonii adhesion was the carboxy-terminal dipeptide Pro-Gln (residues 149 and 150).  (+info)

Concentration and fate of histatins and acidic proline-rich proteins in the oral environment. (4/27)

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Small molecular weight proteins/peptides present in the in vivo formed human acquired enamel pellicle. (5/27)

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Protein expression in salivary glands of rats with streptozotocin diabetes. (6/27)

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Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. (7/27)

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Proline-rich salivary proteins have extended conformations. (8/27)

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Cornified envelope (CE) proline-rich proteins are a group of structural proteins that play an essential role in the formation and integrity of the cornified envelope, which is a tough, protective layer that surrounds the outermost layer of the skin (the stratum corneum). These proteins are rich in the amino acid proline and help to provide mechanical strength and resistance to friction and chemical stressors. They are important for maintaining the barrier function of the skin and preventing water loss. Some examples of CE proline-rich proteins include involucrin, loricrin, and hornerin.

Proline is an organic compound that is classified as a non-essential amino acid, meaning it can be produced by the human body and does not need to be obtained through the diet. It is encoded in the genetic code as the codon CCU, CCC, CCA, or CCG. Proline is a cyclic amino acid, containing an unusual secondary amine group, which forms a ring structure with its carboxyl group.

In proteins, proline acts as a structural helix breaker, disrupting the alpha-helix structure and leading to the formation of turns and bends in the protein chain. This property is important for the proper folding and function of many proteins. Proline also plays a role in the stability of collagen, a major structural protein found in connective tissues such as tendons, ligaments, and skin.

In addition to its role in protein structure, proline has been implicated in various cellular processes, including signal transduction, apoptosis, and oxidative stress response. It is also a precursor for the synthesis of other biologically important compounds such as hydroxyproline, which is found in collagen and elastin, and glutamate, an excitatory neurotransmitter in the brain.

Beta-keratins are a type of keratin proteins that are mainly found in the cells of reptiles, birds, and some mammals such as marsupials. These proteins make up the scales, feathers, claws, beaks, and other hard structures of these animals. Beta-keratins have a different molecular structure compared to alpha-keratins, which are the predominant type of keratins found in mammalian skin, hair, and nails.

Proline-rich protein domains are segments within proteins that contain an unusually high concentration of the amino acid proline. These domains are often involved in mediating protein-protein interactions and can play a role in various cellular processes, such as signal transduction, gene regulation, and protein folding. They are also commonly found in extracellular matrix proteins and may be involved in cell adhesion and migration. The unique chemical properties of proline, including its ability to form rigid structures and disrupt alpha-helices, contribute to the functional specificity of these domains.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

Proline oxidase is an enzyme that catalyzes the chemical reaction of oxidizing proline to Δ^1^-pyrroline-5-carboxylate (P5C) and hydrogen peroxide (H2O2). The reaction is a part of the catabolic pathway for proline utilization in some organisms.

The systematic name for this enzyme is L-proline:oxygen oxidoreductase (deaminating, decarboxylating). It belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as an acceptor. This enzyme participates in arginine and proline metabolism.

LIM domain proteins are a group of transcription factors that contain LIM domains, which are cysteine-rich zinc-binding motifs. These proteins play crucial roles in various cellular processes such as gene regulation, cell proliferation, differentiation, and migration. They are involved in the development and functioning of several organ systems including the nervous system, cardiovascular system, and musculoskeletal system. LIM domain proteins can interact with other proteins and DNA to regulate gene expression and have been implicated in various diseases such as cancer and neurological disorders.

SRC homology domains, often abbreviated as SH domains, are conserved protein modules that were first identified in the SRC family of non-receptor tyrosine kinases. These domains are involved in various intracellular signaling processes and mediate protein-protein interactions. There are several types of SH domains, including:

1. SH2 domain: This domain is approximately 100 amino acids long and binds to specific phosphotyrosine-containing motifs in other proteins, thereby mediating signal transduction.
2. SH3 domain: This domain is about 60 amino acids long and recognizes proline-rich sequences in target proteins, playing a role in protein-protein interactions and intracellular signaling.
3. SH1 domain: Also known as the tyrosine kinase catalytic domain, this region contains the active site responsible for transferring a phosphate group from ATP to specific tyrosine residues on target proteins.
4. SH4 domain: This domain is present in some SRC family members and serves as a membrane-targeting module by interacting with lipids or transmembrane proteins.

These SH domains allow SRC kinases and other proteins containing them to participate in complex signaling networks that regulate various cellular processes, such as proliferation, differentiation, survival, and migration.

Antigens are substances (usually proteins) found on the surface of cells, or viruses, that can be recognized by the immune system and stimulate an immune response. In the context of protozoa, antigens refer to the specific proteins or other molecules found on the surface of these single-celled organisms that can trigger an immune response in a host organism.

Protozoa are a group of microscopic eukaryotic organisms that include a diverse range of species, some of which can cause diseases in humans and animals. When a protozoan infects a host, the host's immune system recognizes the protozoan antigens as foreign and mounts an immune response to eliminate the infection. This response involves the activation of various types of immune cells, such as T-cells and B-cells, which recognize and target the protozoan antigens.

Understanding the nature of protozoan antigens is important for developing vaccines and other immunotherapies to prevent or treat protozoan infections. For example, researchers have identified specific antigens on the surface of the malaria parasite that are recognized by the human immune system and have used this information to develop vaccine candidates. However, many protozoan infections remain difficult to prevent or treat, and further research is needed to identify new targets for vaccines and therapies.

Malaria, Falciparum is defined as a severe and often fatal form of malaria caused by the parasite Plasmodium falciparum. It is transmitted to humans through the bites of infected Anopheles mosquitoes. This type of malaria is characterized by high fever, chills, headache, muscle and joint pain, and vomiting. If left untreated, it can cause severe anemia, kidney failure, seizures, coma, and even death. It is a major public health problem in many tropical and subtropical regions of the world, particularly in Africa.

I'm sorry for any confusion, but "Protozoan Proteins" is not a specific medical or scientific term. Protozoa are single-celled eukaryotic organisms, and proteins are large biological molecules consisting of one or more chains of amino acid residues. Therefore, "Protozoan Proteins" generally refers to the various types of proteins found in protozoa.

However, if you're looking for information about proteins specific to certain protozoan parasites with medical relevance (such as Plasmodium falciparum, which causes malaria), I would be happy to help! Please provide more context or specify the particular protozoan of interest.

'Plasmodium falciparum' is a specific species of protozoan parasite that causes malaria in humans. It is transmitted through the bites of infected female Anopheles mosquitoes and has a complex life cycle involving both human and mosquito hosts.

In the human host, the parasites infect red blood cells, where they multiply and cause damage, leading to symptoms such as fever, chills, anemia, and in severe cases, organ failure and death. 'Plasmodium falciparum' malaria is often more severe and life-threatening than other forms of malaria caused by different Plasmodium species. It is a major public health concern, particularly in tropical and subtropical regions of the world where access to prevention, diagnosis, and treatment remains limited.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Wong RS, Bennick A (June 1980). "The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a ... Proline-rich protein 30 (PRR30 or C2orf53) is a protein in humans that is encoded for by the PRR30 gene. PRR30 is a member in ... Unstructured proteins like PRR30 are highly variable in function. Other Proline-Rich Proteins have been shown to have an ... Bennick A (June 1982). "Salivary proline-rich proteins". Molecular and Cellular Biochemistry. 45 (2): 83-99. doi:10.1007/ ...
Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene. The protein encoded by this gene ... is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as ... PRB1 proline-rich protein BstNI subfamily 1". Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their ... 1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): ...
Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene. The protein encoded by this gene ... is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as ... Precursor proteins, Salivary proline-rich proteins, All stub articles, Protein stubs). ... PRB4 proline-rich protein BstNI subfamily 4". Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their ...
"The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, ... Kim HS, Maeda N (May 1986). "Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family". ... Proline-rich protein HaeIII subfamily 2 is a protein that in humans is encoded by the PRH2 gene. ENSG00000275679, ... "The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f)". The ...
Secondary structure prediction of human salivary proline-rich proteins. FEBS letters, 198(1), 140-144. https://doi.org/10.1016/ ... Hydrophobicity and structural classes in proteins. Protein engineering, 5(5), 373-375. https://doi.org/10.1093/protein/5.5.373 ... Wang, Han; He, Zhiquan; Zhang, Chao; Zhang, Li; Xu, Dong (2013-07-19). "Transmembrane Protein Alignment and Fold Recognition ... Perunov, Nikolay; England, Jeremy L. (2014). "Quantitative theory of hydrophobic effect as a driving force of protein structure ...
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene. The protein encoded by this gene ... PRB3 proline-rich protein BstNI subfamily 3". Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their ... This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich ... "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. ...
v t e (Salivary proline-rich proteins, All stub articles, Protein stubs). ... Other examples include Proline-Rich 12, Proline-Rich Protein 30, and Proline-Rich Protein 21. Canon, Francis; Paté, Franck; ... Tannin-binding capacity of salivary mucin is directly related to its proline content. Advantages in using salivary proline-rich ... Proline-rich proteins (PRPs) is a class of intrinsically unstructured proteins (IUP) containing several repeats of a short ...
The film contains mucins and proline-rich glycoprotein from the saliva. The proteins (statherin and proline-rich proteins) ... The heterogeneous family of proline-rich, human salivary glycoproteins, such as PRB1 and PRH1, are salivary gland-specific ... The salivary glands of some species are modified to produce proteins; salivary amylase is found in many bird and mammal species ... Wikimedia Commons has media related to Salivary glands. Salivary gland at the Human Protein Atlas Illustration at merck.com ...
Salivary acidic proline-rich phosphoprotein 1/2 is a protein that in humans is encoded by the PRH1 gene. ENSG00000277823 GRCh38 ... Kim HS, Maeda N (Jun 1986). "Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family". ... "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. ... "Entrez Gene: PRH1 proline-rich protein HaeIII subfamily 1". Friedman RD, Merritt AD (1990). "Partial purification and ...
These glycoproteins include proline-rich proteins that allow bacterial adhesion. Pellicle somewhat protects enamel, but not ... The surface of enamel and dentin attracts salivary glycoproteins and bacterial products creating the pellicle layer. This thin ... These bacteria are able to replicate in the oxygen-rich environment of the oral cavity and form micro-colonies minutes after ... The dental pellicle, or acquired pellicle, is a protein film that forms on the surface enamel, dentin, artificial crowns, and ...
... proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734-43. doi:10.1177/00220345970760030501. PMID 9109822 ... Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, ... and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. ... The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and ...
Oppenheim FG, Hay DI, Smith DJ, Offner GD, Troxler RF (1987). "Molecular basis of salivary proline-rich protein and peptide ... and proline-rich salivary proteins in humans and macaques". J. Dent. Res. 68 (7): 1138-45. doi:10.1177/00220345890680070101. ... "Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin ... proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734-43. doi:10.1177/00220345970760030501. PMID 9109822 ...
"Immunochemical identification and determination of proline-rich proteins in salivary secretions, enamel pellicle, and glandular ...
... such as salivary alpha-amylase which plays a role in binding and adhesion. Proline-rich proteins (PRP) and statherins are also ... Plaque is rich in species, given the fact that about 1000 different bacterial species have been recognised using modern ... A clean tooth surface would immediately be colonised by salivary pellicles, which acts as an adhesive. This allows the first ... Scannapieco FA, Torres G, Levine MJ (1993). "Salivary alpha-amylase: role in dental plaque and caries formation". Critical ...
... which is a common feature of salivary proline-rich proteins. There are several kinds of proline-rich proteins, which can ... Proline-rich protein 21 (PRR21) is a protein of the family of proline-rich proteins. It is encoded by the PRR21 gene, which is ... Like other proline-rich proteins, it contains a repeated sequence of amino acids that contains several proline residues. The ... The orthologs are poorly conserved, as proline-rich proteins lack the need for specificity. Most important is that they have a ...
Lysozyme Salivary lactoperoxidase Lactoferrin Immunoglobulin A Proline-rich proteins (function in enamel formation, Ca2+- ... Salivary glands also secrete salivary lipase (a more potent form of lipase) to begin fat digestion. Salivary lipase plays a ... Certain salivary proteins prevent precipitation, which would form salts. These ions act as a buffer, keeping the acidity of the ... Some caterpillars produce silk fiber from silk proteins stored in modified salivary glands (which are unrelated to the ...
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) also known as modulator of non-genomic activity of estrogen ... salivary prostate, lung, pancreas, and colon neoplasms. PELP1 signaling contributes to hormonal therapy resistance. Altered ... Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is transcription coregulator and modulates functions of several ... Manavathi B, Nair SS, Wang RA, Kumar R, Vadlamudi RK (July 2005). "Proline-, glutamic acid-, and leucine-rich protein-1 is ...
The FDC-SP gene is also located next to a group of proline-rich salivary peptide genes, which themselves are next several to ... enamelin and proline-rich protein are also located in close proximity to the FDC-SP gene. This indicates that the ... The C-terminal half of FDC-SP is proline-rich and not highly conserved between species, but the alignment of proline residues ... The proline rich region in the C-terminal half bears some resemblance to the antimicrobial peptide Bac5. FDC-SP may therefore ...
This proline-rich region is found to be highly conserved. One long amino acid multiplets of 5 prolines is found at 549. 4 ... This type of glycosylation functions to have proteins fold properly, stabilizes the protein, and plays a role in cell-cell ... and especially in the salivary gland. However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma ... Multiple sequence alignments indicated that the Proline-Rich region from amino residues 39 to 61 near the 5' end of the ...
The WW domains interact with proline rich PPxY motifs in target proteins to mediate interactions with substrates and adaptors. ... "Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+". Proc. Natl. Acad. Sci. U.S.A. 95 ... Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D (1996). "WW domains of Nedd4 bind to the proline-rich PY ... NEDD4 may be hijacked by viral proteins (for example, by UL56 from Herpes simplex virus 2, or by protein VP40 from Ebola virus ...
Despite the fact that its alias is proline-rich protein 2, TMEM171 in humans does not have more proline residues than expected ... It is also expressed at moderate levels in tissues including the spleen, ileum, colon, salivary gland, and expressed at lower ... is a protein that in humans is encoded by the TMEM171 gene. TMEM171 is also known as PRP2 or proline-rich protein 2. It has ... "Transmembrane protein 171 isoform X1". NCBI Protein. "RBPDB: The database of RNA-binding protein specificities". "Anti-TMEM171 ...
Sabatini LM, Azen EA (1989). "Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 ... "Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1 ... Sabatini LM, Ota T, Azen EA (1993). "Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and ... 1988). "Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary ...
Studies using the mouse embryonic P19 cell line have shown isoforms with the short proline rich region (PRR) domain promote ... Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in ... Numb loss has also been demonstrated in Non-small-cell lung carcinoma, salivary gland carcinoma, and chronic myelogenous ... Numb has demonstrated protein-protein interactions with adaptor-related protein complex 2, alpha 1, Mdm2, L1, DPYSL2, SIAH1, ...
... encoding protein Basic salivary proline-rich protein 1 PRB3: encoding protein Basic salivary proline-rich protein 3 PRB4: ... encoding protein Basic salivary proline-rich protein 4 PRH1: encoding protein Salivary acidic proline-rich phosphoprotein 1/2 ... encoding protein Protein arginine methyltransferase 8 PRR4: encoding protein Proline-rich protein 4 PTMS: encoding protein ... encoding protein Protein LMBR1L LRRC23: encoding protein Leucine-rich repeat-containing protein 23 LRRIQ1: encoding protein ...
... two low complexity regions and a proline rich region. The protein is arginine and proline rich, and has a lower than average ... Expression is moderate in the placenta, prostate, testis, lung, salivary glands and dendritic cells. It is low in the brain, ... suggests the INAVA protein interacts with 14-3-3 protein sigma, which is an adaptor protein. INAVA is well conserved in ... The proteins in the MSA are all predicted to localize to the nucleus. A comparison of the physical properties of the proteins ...
1). Finally, further towards the C-terminus, STIM2 contains a proline/histidine-rich motif and a lysine-rich tail of 17 aas ( ... No additional STIM-like proteins have been identified until now in vertebrates. STIM2 protein is a type I transmembrane protein ... to human salivary gland cells as well as dispersed mouse submandibular gland cells increase coimmunoprecipitation of TRPC1 and ... and histidine-rich motif (PHAPHPSHPRHPHHPQHTPHSLPSPDP) at a similar position to a serine- and proline-rich region ( ...
Williamson, M.P. (1994). "The structure and function of proline-rich regions in proteins". Biochemical Journal. 249 (Pt 2): 249 ... and salivary gland. The protein product is less abundant than most of the human proteome in many tissues. There are no known ... 44 prolines were found along the protein, making up 12.3% of the total amino acid sequence. The proline content by percentage ... The first isoform has a non-repeating proline-rich region from amino acids 12 to 80. The function of the region is not well ...
... composed of oral secretions including proteins rich in glycine, proline, alanine, and serine, common components of the silks of ... This groove is associated with the mandibular gland and sac-like gland reservoir used for salivary production. Their larvae ... Proline is a major component of structural proteins and likely contributes to the structural strength of the pedicel in holding ... Another minor component is N-acetylglucosamine, which is probably bound to the pedicel protein. ...
The transmembrane domains also have a shortage of proline (Pro), a helix breaker. The protein sequence contains mixed, positive ... Based on results by Ali2D, the secondary structure of SLC46A3 is rich in α-helices with random coils in between. More precisely ... salivary gland, placenta, and stomach. In fetuses of 10 - 20 weeks, the adrenal gland and intestine report high expression ... S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ...
... encoding protein Proline-rich 12 PRR36 (Proline Rich Region 36) encoding protein PRP36 (Proline Rich Protein 36) KLK3: The ... The Se locus encodes a specific fucosyltransferase that is expressed in the epithelia of secretory tissues, such as salivary ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ... encoding protein Zinc finger protein 180 ZNF208: encoding protein Zinc finger protein 208 ZNF224: encoding protein Zinc finger ...
basic salivary proline-rich protein 1-like Symbol and Name status set to provisional. 70820. PROVISIONAL. ... Gene: LOC120101003 (basic salivary proline-rich protein 1-like) Rattus norvegicus. {{ watchLinkText }} ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine ... urine protein amount (VT:0005160). urine albumin excretion rate (CMO:0000757). 2. 78665619. 219826953. Rat. ...
Wong RS, Bennick A (June 1980). "The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a ... Proline-rich protein 30 (PRR30 or C2orf53) is a protein in humans that is encoded for by the PRR30 gene. PRR30 is a member in ... Unstructured proteins like PRR30 are highly variable in function. Other Proline-Rich Proteins have been shown to have an ... Bennick A (June 1982). "Salivary proline-rich proteins". Molecular and Cellular Biochemistry. 45 (2): 83-99. doi:10.1007/ ...
HSA: Human serum albumin; MW: Molecular weight; pI: Isoelectric point; PRP: Proline-rich protein. ... HSA: Human serum albumin; MW: Molecular weight; pI: Isoelectric point; PRP: Proline-rich protein. ... Simulates a 2D map where the range of isoelectric point and molecular weight of the most abundant classes of salivary proteins ... Simulates a 2D map where the range of isoelectric point and molecular weight of the most abundant classes of salivary proteins ...
We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous ... Genetic polymorphisms of Pe and Po salivary proteins with probable linkage of their genes to the salivary protein gene complex ... Acidic proline-rich protein Db and caries in young children. Zakhary GM, Clark RM, Bidichandani SI, Owen WL, Slayton RL, Levine ... Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2 Nicklas Strömberg ...
Determination of the post-translational modifications of salivary acidic proline-rich proteins.. Castagnola M; Cabras T; ... Protein pI shifts due to posttranslational modifications in the separation and characterization of proteins.. Zhu K; Zhao J; ... Phosphorylation of human high mobility group N1 protein by protein kinase CK2.. Jiang XG; Wang Y. Biochem Biophys Res Commun; ... 7. A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins.. Zhang Q; Zhang K; Zou Y; ...
... proline rich proteins, statherin, and histatins. J. Dent. Res. 76, 734-743 (1997). ... Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus. J. Biol. Chem. 278, 28703- ... Defects leading to protein misfolding or an aberrant unfolded-protein response in intestinal secretory cells lead to intestinal ... Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Sci. ...
... proline rich proteins, defensins, salivary agglutinin and cystatins. These innate immunity effectors are rapidly available and ... glands and lymphoepithelial cysts of the major salivary glands. Occasionally lymphomas may develop within the salivary glands. ... The oral cavity is rich in immune cells, such as CD4+ and CD8+ T cells and their Th1/Th2 subpopulations, Langerhans cells and ... The incidence of salivary gland disease among HIV infected patients appears to have increased following the introduction of ...
Proline-Rich Proteins, Salivary. Salivary Acidic Proline Rich Proteins. Salivary Acidic Proline-Rich Proteins. Salivary Basic ... Proline-Rich Proteins, Salivary Salivary Proline Rich Proteins Salivary Basic Proline-Rich Proteins - Narrower Concept UI. ... Salivary Glycosylated Basic Proline Rich Proteins. Salivary Glycosylated-Basic Proline-Rich Proteins. Salivary Proline Rich ... Salivary Proline-Rich Proteins - Preferred Concept UI. M0516232. Scope note. A family of proline-rich proteins that constitute ...
Salivary Acidic Proline-Rich Proteins Salivary Basic Proline-Rich Proteins Salivary Glycosylated-Basic Proline-Rich Proteins ... Salivary Basic Proline-Rich Proteins Narrower Concept UI. M0516233. Registry Number. 0. Terms. Salivary Basic Proline-Rich ... Salivary Acidic Proline-Rich Proteins Narrower Concept UI. M0516006. Registry Number. 0. Terms. Salivary Acidic Proline-Rich ... A family of proline-rich proteins that constitute the majority of the protein component of SALIVA. Salivary proline-rich ...
Salivary Acidic Proline-Rich Proteins Salivary Basic Proline-Rich Proteins Salivary Glycosylated-Basic Proline-Rich Proteins ... Salivary Basic Proline-Rich Proteins Narrower Concept UI. M0516233. Registry Number. 0. Terms. Salivary Basic Proline-Rich ... Salivary Acidic Proline-Rich Proteins Narrower Concept UI. M0516006. Registry Number. 0. Terms. Salivary Acidic Proline-Rich ... A family of proline-rich proteins that constitute the majority of the protein component of SALIVA. Salivary proline-rich ...
This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing ... human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature ... This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing ... This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded ...
The proteins histatin-1, statherin, salivary acidic proline-rich phosphoprotein ½, proline-rich protein 4, submaxillary gland ... 241 proteins were identified. Basic salivary proline-rich protein 1 and 2, Cystatin-B, and SA were found only in the caries ... A total of 579 proteins were exclusively identified in the CF group and included Leucine-rich alpha-2-glycoprotein, Protein ... In conclusion, the findings indicate that the proteins found at higher levels in the low tooth wear group and proteins ...
Do salivary proline-rich proteins counteract dietary hydrolysable tannin in laboratory rats? Journal of Chemical Ecology. 2004; ... Proline-rich proteins (PRPs) and histatins together with PPs form stable complexes in the oral cavity which remain stable ... Chocolate is very rich in PPs, and a minor consumption of chocolate may significantly contribute to total polyphenol intake 68 ... Salivary alpha-amylase: role in dental plaque and caries formation. Critical Reviews in Oral Biology and Medicine. 1993;4:301-7 ...
This protein plays an essential role in the regulation of hematopoiesis. MYB may be aberrently expressed or rearranged or ... MYB encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. ... Human Basic salivary proline-rich protein 2 (PRB2) ELISA Kit $339.00. - $24,569.00. ... MYB encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an ...
Mapping of Transglutaminase-2 Sites of Human Salivary Small Basic Proline-Rich Proteins by HPLC-High-Resolution ESI-MS/MS 1-gen ... Mapping of Transglutaminase-2 Sites of Human Salivary Small Basic Proline-Rich Proteins by HPLC-High-Resolution ESI-MS/MS. ... A Catalog of Coding Sequence Variations in Salivary Proteins Genes Occurring during Recent Human Evolution 1-gen-2023 Di ... The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms 1-gen-2023 Messana ...
... that bind preferentially to salivary acidic proline-rich proteins and to statherin, or to β-linked galactose or galactosamine ...
Salivary Proline-Rich Proteins. Proteínas Salivales Ricas en Prolina. Proteínas Substratos do Receptor de Insulina. Insulin ... Proline-Rich Protein Domains. Dominios Proteicos Ricos en Prolina. Estabilidade Proteica. Protein Stability. Estabilidad ... Cornified Envelope Proline-Rich Proteins. Proteínas Ricas en Prolina del Estrato Córneo. ... Cysteine-Rich Protein 61. Proteina 61 Rica en Cisteína. Proteína Sobreexpressa em Nefroblastoma. Nephroblastoma Overexpressed ...
Carlson D (2016) Salivary Proline-rich Proteins: Biochemistry, Molecular Biology, and Regulation of Expression, Critical ...
Salivary α-amylase serum albumin and myoglobin however not salivary proline-rich proteins decreased harm from tea espresso and ... For instance between varieties the secretion level of salivary proline-rich proteins (PRPs) responds to the amount of tannin in ... 2.2 Substances tested 2.2 Protein preparations BSA horse myoglobin human being salivary α-amylase and protein A from were (Glp1 ... 1995 Additionally cells proteins diet proteins and albumin in blood might limit DNA damage. Serum albumin for example binds ...
HN - 2009(1979) FX - Cornified Envelope Proline-Rich Proteins FX - Salivary Proline-Rich Proteins MH - Protein Multimerization ... Salivary Proline-Rich Proteins UI - D055273 MN - D12.644.848.937 MN - D12.776.850.925 MS - A family of proline-rich proteins ... HN - 2009(1979); use PROLINE-RICH PROTEIN DOMAINS 1980-2008 FX - Proline-Rich Protein Domains MH - Salt-Tolerance UI - D055049 ... Salivary proline-rich proteins occur as acidic, basic and glycosylated basic proteins. They perform a variety of functions such ...
Proline Rich Proteins) precipitation and insolubility or the degradation of the salivary pellicle, the COF may be a vital ... The role of salivary proteins in the mechanism of astringency. J. Food Sci. 2012;77(4):C381-7. ... However, three different hypotheses exist: 1) Soluble tannin-protein aggregates deplete the salivary film and expose the oral ... Another material not as commonly used in technical research, but with great promise, is whey protein-isolate gels. In terms of ...
As deduced from the primary sequence AgI/II has discontinuous alanine (A)- and proline (P)-rich tandem repeats that flank a ... AgI/II family members mediate interactions with host salivary constituents cell CBLC matrix proteins and other bacteria ( ... have been studied as vaccine candidates [2-6]. One such protein is the cell-surface localized Antigen I/II adhesin [7] also ... upstream of the alanine-rich repeat domain. Adherence inhibiting antibodies could be induced against two discrete domains of ...
Androgen administration also led to a 40 fold decrease in the mRNA level of small proline-rich protein 2A (SPPR2A). This gene, ... levels in salivary, respiratory, intestinal, uterine or bladder tissues, and actually decrease IgA amounts in the mammary gland ... mRNA levels of the small proline-rich proteins 2F and 2A, respectively, in meibomian gland epithelial cells. ... a serine/threonine protein kinase that may modulate cell growth, cell proliferation, cell motility, cell survival, protein ...
Salivary Cystatins. Cistatinas Salivares. Cistatinas Salivares. Salivary Proline-Rich Proteins. Proteínas Salivares Ricas em ... Cornified Envelope Proline-Rich Proteins. Proteínas Ricas em Prolina do Estrato Córneo. Proteínas Ricas en Prolina del Estrato ... Proline-Rich Protein Domains. Domínios Proteicos Ricos em Prolina. Dominios Proteicos Ricos en Prolina. ... Salivary alpha-Amylases. alfa-Amilases Salivares. alfa-Amilasas Salivares. Seed Storage Proteins. Proteínas de Armazenamento de ...
Salivary Cystatins. Cistatinas Salivares. Cistatinas Salivares. Salivary Proline-Rich Proteins. Proteínas Salivares Ricas em ... Cornified Envelope Proline-Rich Proteins. Proteínas Ricas em Prolina do Estrato Córneo. Proteínas Ricas en Prolina del Estrato ... Proline-Rich Protein Domains. Domínios Proteicos Ricos em Prolina. Dominios Proteicos Ricos en Prolina. ... Salivary alpha-Amylases. alfa-Amilases Salivares. alfa-Amilasas Salivares. Seed Storage Proteins. Proteínas de Armazenamento de ...
parotid proline-rich salivary protein pc [NCBI] 0.000503231 GALT [NCBI] 0.000502457 GSR [NCBI] 0.000481919 IFNB1 [NCBI] ...
Human PRB1(Basic Salivary Proline Rich Protein 1) ELISA Kit. *Human PRB2(Basic Salivary Proline Rich Protein 2) ELISA Kit ... Human PRELP(Proline Arginine Rich End Leucine Rich Repeat Protein) ELISA Kit ... Human MAP2K1(Mitogen Activated Protein Kinase Kinase 1) ELISA Kit. *Human MARCKS(Myristoylated Alanine Rich Protein Kinase C ... Human CRHBP(Corticotropin Releasing Hormone Binding Protein) ELISA Kit. *Human CRIP1(Cysteine Rich Protein 1, Intestinal) ELISA ...
Human PRB1(Basic Salivary Proline Rich Protein 1) ELISA Kit. *Human PRB2(Basic Salivary Proline Rich Protein 2) ELISA Kit ... Human PRELP(Proline Arginine Rich End Leucine Rich Repeat Protein) ELISA Kit ... Human CRHBP(Corticotropin Releasing Hormone Binding Protein) ELISA Kit. *Human CRIP1(Cysteine Rich Protein 1, Intestinal) ELISA ... Human CYR61(Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit. *Human DAG1(Dystrophin Associated Glycoprotein 1) ELISA ...
Human PRB1(Basic Salivary Proline Rich Protein 1) ELISA Kit. *Human PRB2(Basic Salivary Proline Rich Protein 2) ELISA Kit ... Human PRELP(Proline Arginine Rich End Leucine Rich Repeat Protein) ELISA Kit ... Human PRELP(Proline Arginine Rich End Leucine Rich Repeat Protein) ELISA Kit ... Human MAP2K1(Mitogen Activated Protein Kinase Kinase 1) ELISA Kit. *Human MARCKS(Myristoylated Alanine Rich Protein Kinase C ...
  • The presence of mononuclear cell aggregates around the ducts and acini of salivary glands results in functional and structural alterations at the level of these glands and impairs their secretory function. (intechopen.com)
  • The salivary glands of SS patients are characterized by chronic inflammation with the presence of lymphocytic infiltrates located around the striated ducts. (intechopen.com)
  • The presence of foci in labial salivary glands is a hallmark of SS, and their histopathologic analysis is an important item in the diagnosis and classification. (intechopen.com)
  • The authors present the main ultrasonic signs of SS major salivary glands and perspectives of the usage of salivary gland ultrasonic examination in the diagnosis and monitoring of SS. (intechopen.com)
  • For example, in 1869 a physician wrote that chewing gum would "exhaust the salivary glands and cause the intestines to stick together. (dentistrytoday.com)
  • In humans, saliva is generated by 3 pairs of major and numerous minor salivary glands. (dentistrytoday.com)
  • The major salivary glands produce 93% of all saliva. (dentistrytoday.com)
  • 4 The salivary glands are under the control of the autonomic nervous system and respond to hormonal influences. (dentistrytoday.com)
  • An issue with your salivary glands or disorders might cause chronic dry mouth. (healthysupplementsguide.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in samples from saliva or other biological fluids. (glideruniversity.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in saliva and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in samples from saliva and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • In the present study, we show that the heterogeneous mixture of glycoforms of the basic salivary proline-rich protein 3M, encoded by PRB3-M locus, is a major component of the acidic soluble fraction of human whole saliva in the first years of life. (unicatt.it)
  • Saliva in SS is characterized by the increased concentration of lactoferrin, potassium and cystatin C and the decreased concentration of amylase, carbonic anhydrase, mucins, histatines, IgA, statherins, proline-rich proteins, and the loss of salivary buffer properties. (intechopen.com)
  • Aside from lubricating the tissues, saliva helps maintain a pH environment that promotes tooth remineralization via deposition of ionic minerals available in solution and serves an antimicrobial function as a result of the immunoglobulins and proteins present in the fluid. (dentistrytoday.com)
  • Following ingestion of a dietary sugar, the stimulated production of saliva ceases after the sugar clears the mouth, and salivary output returns to a resting state within a short time.5,6 The tooth is most susceptible to demineralization and white spot production during the period of lowered pH. (dentistrytoday.com)
  • The importance of saliva is clearly observed after salivary flow is reduced. (dentistrytoday.com)
  • Some of these proteins increased the binding of S. gordonii to saliva-coated brackets. (snu.ac.kr)
  • The search for reliable salivary biomarkers for early detection of OSCC has developed rapidly, spurred on by the fact that collecting saliva is relatively easy and non-invasive, compared to the drawing of blood. (springeropen.com)
  • A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal. (lookformedical.com)
  • Previous research with rats demonstrated that when the animals were fed a diet of bitter food, the expression of these flavour proteins in the rodents' saliva was altered. (sciencealert.com)
  • Changes in the makeup of their saliva were also taking place, with Running observing that the levels of proline-rich proteins - which can bind to the bitter and/or astringent compounds in the milk - was increasing in the participants' saliva. (sciencealert.com)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
  • The results showed that low-molecular-weight mucin, alpha-amylase, secretory IgA, acidic proline-rich proteins, and cystatins adhered to all kinds of brackets, though the amino acid composition of pellicles differed between bracket types. (snu.ac.kr)
  • Definition Dental Plaque "is a specific but highly variable structural entity, resulting from sequential colonization of microorganisms on tooth surfaces, restorations & other parts of oral cavity, composed of salivary components like mucin, desquamated epithelial cells, debris & microorganisms, all embedded in extracellular gelatinous matrix. (medicpresents.com)
  • Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. (metabiom.org)
  • The ribonucleotide-protein complex signal recognition particle (SRP) is conserved in all three domains of life and delivers membrane and secretory proteins to the cyoplasmic membrane or endoplasmic reticulum. (ufl.edu)
  • Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body. (psyclopeptide.com)
  • These bacteria or yeast secrete their proteolytic enzymes in due course to release peptides from the proteins. (psyclopeptide.com)
  • A biopsy can be taken from either the labial or the parotid salivary gland, but currently according to the diagnostic criteria, only labial salivary gland biopsy (LSGB) is recommended to confirm the diagnosis of SS. (intechopen.com)
  • The authors present their own experience and recommendations in taking labial salivary gland biopsy, the main surgical approaches, and the main limitations for this diagnostic method and describe the possibilities and principles of histopathological examination in SS. (intechopen.com)
  • A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w. (shengsci.com)
  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. (cancerindex.org)
  • Organic Component Organic constituents : polysaccharides, proteins, glycoproteins, and lipid material Polysaccharides produced by bacteria-Dextran: predominant form Albumin: originating from crevicular fluid Lipid material: debris from the membranes of disrupted bacterial and host cells and possibly food debris. (medicpresents.com)
  • Composed of proteins and glycoproteins. (medicpresents.com)
  • From the late 1990s until the present, more than 40 research studies have been published and more than 100 different salivary constituents have been suggested as potential OSCC salivary biomarkers (see Table 1 ). (springeropen.com)
  • and studies of intra- and inter-molecular protein-protein interactions relevant for bacterial protein stability, function and adhesive interactions with host constituents. (ufl.edu)
  • Due to the presence of histatins (proline-rich proteins including cystatins and statherin), calcium and phosphate are maintained in supersaturation and are available for remineralization of tooth structure. (dentistrytoday.com)
  • Proline-rich protein 30 (PRR30 or C2orf53) is a protein in humans that is encoded for by the PRR30 gene. (wikipedia.org)
  • This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • The salivary MUC7 gene provides an opportunity for studying such variation, as it harbors copy number variable subexonic repeat sequences that encode for densely O-glycosylated domains (PTS-repeats) with microbe-binding properties. (nature.com)
  • Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. (shengsci.com)
  • A gene discovery approach is being used to identify global changes in protein expression that occur when adhesin P1 is engaged with a physiological binding partner. (ufl.edu)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Second, the subexonic repeats of MUC7 code for densely O-glycosylated proline-, threonine-, and serine-rich (PTS) tandem repeat domains. (nature.com)
  • Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. (lookformedical.com)
  • Protein is hydrolyzed by culturing bacteria or yeast on the protein substrates. (psyclopeptide.com)
  • Streptococci also encode two homologs of the evolutionary conserved YidC/Oxa/Alb family of membrane-associated chaperones expressed by bacteria, mitochonidria, and chloroplasts that mediate and contribute to the insertion of membrane proteins and multi subunit complexes, including components of the F1F0 ATP synthase. (ufl.edu)
  • We have characterized multiple conformational epitopes recognized by monoclonal antibodies against the P1 adhesin of S. mutans and demonstrated that the an intra-molecular interaction between the amino-terminal alanine-rich repeat and central proline-rich repeat domains is necessary for the structural integrity, surface localization and function of the molecule. (ufl.edu)
  • It's also worth noting that Chlorella Vulgaris extract is high in amino acids like glycine, proline, lysine, and alanine, which are necessary protein building blocks that make up each collagen unit. (healthysupplementsguide.com)
  • Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
  • Natural cleansing mechanism: Gingival crevicular fluid & salivary flow Cleansing effect of mastication and tongue movement Rapid turnover rate of intraoral epithelial cells Host defence mechanisms like langerhans cells. (medicpresents.com)
  • A. naeslundii, which was formerly referred to as genospecies 1 , and A. oris bind to PRPs and statherin, a phosphate-containing protein in salivary components [ 1 ]. (biomedcentral.com)
  • The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. (shengsci.com)
  • consistently, it could be significantly enhanced by supplementation with either polyphenol-rich extracts or individual compounds. (docksci.com)
  • It's early days, but the researchers want to find out more about what's going on here, looking at what kinds of particular compounds in food are eliciting changes in our salivary proteins, and investigating how long it takes for our taste buds to adapt to new, disliked tastes. (sciencealert.com)
  • Also, in collaboration with Dr. Champion Deivanayagam of the Center for Biophysical Sciences and Engineering at the University of Alabama we are utilizing X-ray crystallography in conjunction with protein interaction methodologies to define the structure of P1 and to identify the binding motif responsible for its interaction with the high molecular weight gp340 salivary agglutinin ligand. (ufl.edu)
  • Description: A sandwich ELISA kit for detection of Basic Salivary Proline Rich Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
  • PRR30 Splice Pattern Human protein PRR30 consists of 412 amino acid residues. (wikipedia.org)
  • IntAct predicts that PRR30 interacts with Human Testis Protein 37 or TEX37, Cystiene Rich Tail Protein 1 (CYSRT1), and Keratin Associated Protein 6-2 (KRTAP6-2). (wikipedia.org)
  • Other Proline-Rich Proteins have been shown to have an affinity for binding calcium across different tissues in the human body. (wikipedia.org)
  • N- and O-linked glycosylation site profiling of the human basic salivary proline-rich protein 3M. (unicatt.it)
  • The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
  • Human PRB1 Protein (raised in Insect Cells) purified by multi-step, protein-specific process to ensure crystallization grade. (antibodies-online.com)
  • Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among all major human cancers. (springeropen.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Jagged 1 Protein (JAG1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (kits-elisa.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Jagged 1 Protein (JAG1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
  • Description: A sandwich ELISA kit for detection of GRB2 Related Adaptor Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
  • Description: A sandwich ELISA kit for detection of High Mobility Group AT Hook Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human High Mobility Group AT Hook Protein 1 (HMGA1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human G Protein Coupled Receptor 120 (GPR120) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
  • Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
  • The need for protection afforded by salivary buffers is highest after carbohydrate consumption. (dentistrytoday.com)
  • 2015). Determining the composition of protein, carbohydrate, moisture, fat, and ash in raw EBN is essential for various purposes, including the hydrolysis process for the extraction of its valuable components. (researchgate.net)
  • A pure form of proteolytic enzyme is used to hydrolyze the protein to produce short peptide sequences. (psyclopeptide.com)
  • Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
  • Incubation of #Porphyromonas gingivalis , a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions. (metabiom.org)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • By raising the awareness of these issues on the part of both researchers and clinicians, it is hoped that reliable, specific and sensitive salivary biomarkers may be found soon-and not only biomarkers for early OSCC detection but also for detecting other types of cancers or even for monitoring non-cancerous disease activity. (springeropen.com)
  • Addressing these issues not only will serve to accelerate progress toward finding reliable salivary biomarkers for early OSCC detection, but also should have a positive effect on the search of reliable salivary biomarkers for other types of cancer detection or even for monitoring non-cancerous disease activity. (springeropen.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
  • Our results establish MUC7 as a major player in salivary adaptation, likely as a response to diverse pathogenic exposure in primates. (nature.com)
  • This review article will provide an up-to-date list of potential OSCC salivary biomarkers, as of the fall of 2013, and will focus on some emerging issues/challenges that seem to be major roadblocks on the way to bringing reliable salivary biomarkers into actual clinical use. (springeropen.com)
  • Using affinity chromatography coupled to multidimensional protein identification technology (MudPIT), DEAF-1 was identified as a candidate regulator. (sdbonline.org)
  • To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
  • Homo est devenu un consommateur régulier de produits carnés en complément des végétaux et d'insectes. (ocl-journal.org)
  • Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)
  • Whatever your level of training, you need to ensure your basic nutrition provides adequate calories, vitamins, minerals, protein and water, you may then consider specific supplements. (newimage.asia)
  • After immunoprecipitation of Akt, the kinase reaction was performed using the instructions provided by the manufacturer with glycogen synthase kinase (GSK)-3 fusion protein as an exogenous substrate. (srcinhibitors.com)
  • Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
  • Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. (jci.org)
  • Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
  • This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
  • In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. (jci.org)
  • Collectively, salivary pellicles were found to play a significant role in the initial adhesion of oral streptococci to orthodontic brackets. (snu.ac.kr)
  • Proteins found in any species of fungus. (lookformedical.com)
  • It was also found that both nests share a common 77 KDa protein that has properties similar to those of the ovotransferrin protein in eggs. (researchgate.net)
  • Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota. (metabiom.org)
  • Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. (shengsci.com)
  • In the oral cavity, polyphenols (particularly flavanols and proanthocyanidins), partially released from the food matrix, are able to interact with salivary proteins rich in proline. (docksci.com)
  • An unstimulated salivary flow rate of 0.1 ml/min in sialometry gives a score of 1 to the weighted sum of 5 items according to the current EULAR/ACR criteria. (intechopen.com)
  • A modified xanthoproteic nitric acid test for proteins proved to be a rapid, and simple test to detect adulteration in both whole and finely ground nests, and would be suitable in the field where analytical facilities are not readily available. (researchgate.net)
  • Unstructured proteins like PRR30 are highly variable in function. (wikipedia.org)
  • Consistent with a cell-cycle regulatory function, CYLD localizes to microtubules in interphase and the midbody during telophase CYLD 's protein levels decrease as cells exit from mitosis. (medscape.com)
  • by the reduction of the available -OH group interacting with salivary proteins, the direct eliciting capacity of anthocyanins is far from clear. (oeno-one.eu)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • In the unlikely event that the protein cannot be expressed or purified we do not charge anything (other companies might charge you for any performed steps in the expression process for custom-made proteins, e.g. fees might apply for the expression plasmid, the first expression experiments or purification optimization). (antibodies-online.com)
  • If we can change the expression of these proteins, maybe we can make the 'bad' flavours like bitterness and astringency weaker," Running explains . (sciencealert.com)
  • Recent reports indicate that the inflammatory response triggered by tissue damage is mediated by a multiple-protein complex called the inflammasome. (bvsalud.org)