Salicylates
Sodium Salicylate
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
Salicylic Acid
Aspirin
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Hydroxybenzoates
Benzoic Acid
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Tinnitus
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
Pseudomonas
Reye Syndrome
Chorismic Acid
Cyclooxygenase Inhibitors
Catechol 1,2-Dioxygenase
Gaultheria
Dioxygenases
Phenylbutazone
Hair Cells, Auditory, Outer
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Benzoates
Naphthalenes
Phenacetin
Perinatal nephropathies. (1/1030)
The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation. (+info)Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)
Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate. (+info)Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)
The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated. (+info)Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin. (+info)NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)
Two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10. While nahG resides in the same transcriptional unit as the meta-cleavage pathway genes, forming the naphthalene degradation lower pathway, nahW is situated outside but in close proximity to this transcriptional unit. The nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism. Both genes, nahG and nahW, have been cloned in Escherichia coli JM109. The overexpression of these genes yields peptides with apparent molecular masses of 46 kDa (NahG) and 43 kDa (NahW), respectively. Both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates, and chlorosalicylates. However, the relative rates by which the substituted analogs are transformed differ considerably. (+info)4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)
1. The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the activation of NF-kappaB elicited by tumour necrosis factor-alpha (TNF-alpha) on human umbilical vein endothelial cells (HUVEC) was tested. 2. The expression of the mRNA of vascular cell adhesion molecule-1 (VCAM-1) was studied as an example of a gene the expression of which is regulated by NF-kappaB. To extend these findings to other systems, the induction of nitric oxide synthase in rat adherent peritoneal macrophages was studied. 3. Both HTB and triflusal were more potent than aspirin or salicylate as inhibitors of the nuclear translocation of NF-kappaB. The calculation of the IC50 values showed approximately 2 mM for HTB, 4 mM for aspirin and >4 mM for salicylate. 4. Comparison of the potency of these compounds on VCAM-1 mRNA expression showed complete inhibition by both triflusal and HTB at a concentration of 4 mM whereas aspirin and salicylate produced only 36-43% inhibition at the same concentration. 5. Inhibition of NF-kappaB activation was also observed in rat peritoneal macrophages stimulated via their receptors for the Fc portion of the antibody molecule with IgG/ovalbumin immune complexes. This was accompanied by a dose-dependent inhibition of nitrite production by the L-arginine pathway via iNOS. IC50 values for this effect were 1.13+/-0.12 mM (triflusal), 1.84+/-0.34 (HTB), 6.08+/-1.53 mM (aspirin) and 9.16+/-1.9 mM (salicylate). 6. These data indicate that the incorporation of a 4-trifluoromethyl group to the salicylate molecule strongly enhances its inhibitory effect on NF-kappaB activation, VCAM-1 mRNA expression and iNOS induction, irrespective of the presence of the acetyl moiety involved in the inhibition of cyclo-oxygenase. (+info)Reye's syndrome in the United States from 1981 through 1997. (7/1030)
BACKGROUND: Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella. Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome. METHODS: To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and risk factors for poor outcomes, we analyzed national surveillance data collected from December 1980 through November 1997. The surveillance system is based on voluntary reporting with the use of a standard case-report form. RESULTS: From December 1980 through November 1997 (surveillance years 1981 through 1997), 1207 cases of Reye's syndrome were reported in patients less than 18 years of age. Among those for whom data on race and sex were available, 93 percent were white and 52 percent were girls. The number of reported cases of Reye's syndrome declined sharply after the association of Reye's syndrome with aspirin was reported. After a peak of 555 cases in children reported in 1980, there have been no more than 36 cases per year since 1987. Antecedent illnesses were reported in 93 percent of the children, and detectable blood salicylate levels in 82 percent. The overall case fatality rate was 31 percent. The case fatality rate was highest in children under five years of age (relative risk, 1.8; 95 percent confidence interval, 1.5 to 2.1) and in those with a serum ammonia level above 45 microg per deciliter (26 micromol per liter) (relative risk, 3.4; 95 percent confidence interval, 1.9 to 6.2). CONCLUSIONS: Since 1980, when the association between Reye's syndrome and the use of aspirin during varicella or influenza-like illness was first reported, there has been a sharp decline in the number of infants and children reported to have Reye's syndrome. Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome. (+info)Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)
OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels. (+info)
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Morpholine salicylate
... is a nonsteroidal anti-inflammatory drug. "Morpholine Salicylate". drugs.com. Koda A, Sakai K, Nagai H, ... Suzuki Y, Kobayashi T (September 1967). "[Pharmacological action of morpholine salicylate]". Nihon Yakurigaku Zasshi. Folia ...
Copper salicylate
... is a compound with formula Cu(C7H5O3). It is the copper salt of salicylic acid. A copper(II) monosalicylate ...
Potassium salicylate
Salicylates, Potassium compounds, 3-Hydroxypropenals, All stub articles, Chemistry stubs). ... Potassium salicylate is the potassium salt of salicylic acid. http://www.chemicalbook.com/ChemicalProductProperty_EN_CB4157001. ...
Salicylate sensitivity
... is any adverse effect that occurs when a usual amount of salicylate is ingested. People with salicylate ... Salicylate sensitivity differs from salicylism, which occurs when an individual takes an overdose of salicylates. Salicylate ... Salicylate sensitivity can be treated with the use of low-salicylate diets, such as the Feingold Diet. The Feingold Diet ... Salicylates can also be found in many medications, perfumes and preservatives. Both natural and synthetic salicylates can cause ...
Ethyl salicylate
Methyl salicylate Isopropyl salicylate Pubchem. "Ethyl salicylate". pubchem.ncbi.nlm.nih.gov. Retrieved 25 February 2018. ... Ethyl salicylate is the ester formed by the condensation of salicylic acid and ethanol. It is a clear liquid that is sparingly ... "Fragrance material review on ethyl salicylate". Food and Chemical Toxicology. 45: S397-401. doi:10.1016/j.fct.2007.09.043. PMID ... Salicylate esters, 3-Hydroxypropenals, All stub articles, Ester stubs). ...
Salicylate decarboxylase
... (EC 4.1.1.91, salicylic acid decarboxylase, Scd) is an enzyme with systematic name salicylate carboxy- ... Salicylate+decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 4.1.1). ... This enzyme catalyses the following chemical reaction salicylate ⇌ {\displaystyle \rightleftharpoons } phenol + CO2 In the ... reverse direction the enzyme catalyses the regioselective carboxylation of phenol into salicylate. Kirimura K, Gunji H, ...
Salicylate synthase
... is an enzyme that catalyzes the chemical reaction: chorismate → salicylic acid MbtI is the responsible ... Zwahlen (January 30, 2007). "Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis". {{cite ...
Sodium salicylate
... is of the salicylate family. It is used in medicine as an analgesic and antipyretic. Sodium salicylate also ... Wikimedia Commons has media related to Sodium salicylate. Chemicalland21 Some synonyms Safety data for sodium salicylate at ... Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher ... "sodium salicylate". chemister.ru. Retrieved 8 April 2018. Chambers, Michael. "ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA- ...
Trolamine salicylate
Methyl salicylate From DailyMed (a publication of the National Institutes of Health) [1], retrieved 23 April 2011 Steven Pray, ... Trolamine salicylate (Aspercreme, Aspergel) is an organic compound which is the salt formed between triethanolamine and ... Due to health concerns, in 2019 the FDA issued a proposed rule classifying the sunscreen use of trolamine salicylate as "not ... Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this ...
Isopropyl salicylate
Methyl salicylate Ethyl salicylate Pubchem. "Isopropyl salicylate". pubchem.ncbi.nlm.nih.gov. Retrieved 10 March 2021. " ... Isopropyl salicylate is the ester formed by the condensation of salicylic acid and isopropyl alcohol. It is a transparent ... "Isopropyl salicylate, 99%, ACROS Organics , Fisher Scientific". v t e (Articles without KEGG source, ECHA InfoCard ID from ... Salicylate esters, 3-Hydroxypropenals, All stub articles, Ester stubs). ...
Octyl salicylate
... , or 2-ethylhexyl salicylate, is an organic compound used as an ingredient in sunscreens and cosmetics to ... The salicylate portion of the molecule absorbs ultraviolet light, protecting skin from the harmful effects of exposure to ... Octisalate and all other salicylates have a good safety profile. It is often used to improve affinity and reduce ...
Salicylate testing
... is a category of drug testing that is focused on detecting salicylates such as acetysalicylic acid for ... technology that can determine the presence and quantify salicylates. The introduction of a salicylate specific antigen labeled ... Salicylates can be identified by GC/MS, proton NMR, and IR.[citation needed] One of the first in vitro tests for aspirin was ... It is therefore possible to quantify the serum salicylate level through the signal strength-the amount of reflected light ...
Estradiol salicylate
... , or estradiol 3-salicylate, is a synthetic estrogen and estrogen ester - specifically, the C3 salicylic ... It is a metabolite of estradiol acetylsalicylate, which appears to be very rapidly hydrolyzed into estradiol salicylate. List ...
Methyl salicylate
... is believed to function by being metabolized to the plant hormone salicylic acid. Since methyl salicylate is ... Salicylate, the major metabolite of methyl salicylate, may accumulate in blood, plasma or serum to confirm a diagnosis of ... Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized ... However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID. Methyl salicylate is used in low ...
Magnesium salicylate
"Magnesium Salicylate Tablet - Uses, Side Effects, and More". WebMD. WebMD LLC. Retrieved March 30, 2022. "Magnesium Salicylate ... While magnesium salicylate is sold as an alternative for pain relief, it is still a nonsteroidal anti-inflammatory drug and, ... Magnesium salicylate is a common analgesic and nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate ... Magnesium salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflammatory and pain-relieving ...
Phenyl salicylate
... if he knew of a salicylate compound that lacked sodium salicylate's side effects. Nencki recommended phenyl salicylate, which ... Phenyl salicylate, or salol, is the organic compound with the formula C6H5O2C6H4OH. It is a white solid. It is occasionally ... Heating phenyl salicylate in turn gives xanthone. 2 C6H5O2C6H4OH → 2 C6H5OH + O[C6H4]2CO + CO2 In this conversion, phenol is ... Phenyl salicylate is used in school laboratory demonstrations on how cooling rates affect crystal size in igneous rocks, and ...
Benzyl salicylate
... is a salicylic acid benzyl ester, a chemical compound most frequently used in cosmetics as a fragrance ... ISBN 0-931710-37-5 "Benzyl salicylate". The Good Scents Company. Belsito, D; Bickers, D; Bruze, M; Calow, P; Greim, H; Hanifin ... Salicylates" (PDF). Food and Chemical Toxicology. 45 (Supplement 1): S1-23. doi:10.1016/j.fct.2007.09.087. PMID 18035463. " ...
Salicylate poisoning
... , also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. The ... High doses of salicylate can cause salicylate-induced tinnitus. The severity of toxicity depends on the amount of aspirin taken ... Oral sodium bicarbonate is contra-indicated in salicylate toxicity as it can cause dissociation of salicylate tablets in the GI ... is an effective method to increase the clearance of salicylates from the body. Alkalinization of the urine causes salicylates ...
Salicylate 1-monooxygenase
Other names in common use include salicylate hydroxylase, salicylate 1-hydroxylase, salicylate monooxygenase, and salicylate ... In enzymology, a salicylate 1-monooxygenase (EC 1.14.13.1) is an enzyme that catalyzes the chemical reaction salicylate + NADH ... doi:10.1016/0005-2744(69)90316-7. Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate ... Suzuki K, Takemori S, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. IV. Fluorimetric analysis of the ...
Trinder spot test
Salicylate testing Leslie M. Shaw; Tai C Kwong; Barbarajean Magnani (2001). "Clinical Approach to the Poisoned Patient". The ... J.A. King; A.B. Sorrow; J.A. Finkelstein (1995). "Urine Trinder spot test: a rapid salicylate screen for the emergency ... The Trinder spot test is a diagnostic test used in medicine to determine exposure to salicylates, particularly to salicylic ... ISBN 978-1-890883-53-9. Neal Flomenbaum (2006). "Salicylates". In Lewis R. Goldfrank; Neal Flomenbaum; Mary Ann Howland; Robert ...
Spiraea
... contain salicylates. Acetylsalicylic acid was first isolated from Filipendula ulmaria,[citation needed] a species at ...
Aloxiprin
Use with other salicylates. Use with NSAIDs. MIMS. "Aloxiprin". MIMS. Retrieved 16 April 2011. Encarta. "Aloxiprin". Encarta. ... People with allergies to salicylates. People with gastrointestinal ulcers. People with liver or kidney damage. Pregnant women ...
Salicylic acid
Meanwhile, German scientists tried sodium salicylate with less success and more severe side effects. In 1979, salicylates were ... Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) ... Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used ... Methyl salicylate is taken up by the stomata of the nearby plant, where it can induce an immune response after being converted ...
Edward Stone (natural philosopher)
175-. ISBN 978-1-4398-0774-3. K. D. Rainsford (22 October 2013). Aspirin and the Salicylates. Elsevier. p. 2. ISBN 978-1-4831- ... A less corrosive compound of salicylic acid, acetylsalicylic acid, produced by reacting sodium salicylate with acetyl chloride ...
Acetazolamide
Salicylates, potential for severe toxicity. Sodium bicarbonate, potential for kidney stone formation. Anticoagulants, cardiac ...
Rheumatic fever
Salicylates are useful for pain.[citation needed] Steroids are reserved for cases where there is evidence of an involvement of ... One should watch for side effects like gastritis and salicylate poisoning. In children and teenagers, the use of aspirin and ...
Uncoupling protein
ISBN 978-1-133-10879-5. "California Poison Control System: Salicylates". Archived from the original on 2014-08-02. Gong DW, He ...
Acetaminosalol
Brewster, R. Q. (1918). "ACETYLAMINOPHENYL SALICYLATE. THE PREPARATION OF SALOPHEN". Journal of the American Chemical Society. ... Salicylate esters, Acetanilides, Analgesics, 3-Hydroxypropenals, Phenol esters, All stub articles, Analgesic stubs, Ester stubs ...
Aspirin
Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate. Aspirin ... Done AK (November 1960). "Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ... Plasma salicylate levels in general range from 30 to 100 mg/L after usual therapeutic doses, 50-300 mg/L in people taking high ... Large doses of salicylate, a metabolite of aspirin, cause temporary tinnitus (ringing in the ears) based on experiments in rats ...
Poison Prevention Packaging Act of 1970
Methyl salicylate. Liquid preparations containing more than 5% by weight of methyl salicylate, other than those packaged in ...
Salicylates Level: MedlinePlus Medical Test
Salicylates are a type of drug found in aspirin and other medicines. Salicylates are usually safe for adults when taken at the ... This test measures the amount of salicylates in blood. ... Salicylates are a type of drug found in many over-the-counter ... What is a salicylates level test?. This test measures the amount of salicylates in the blood. ... A salicylates level test is most often used to:. *Help diagnose acute or gradual aspirin poisoning. Acute aspirin poisoning ...
Browsing by Subject "Salicylates"
Surgeon General's Advisory on the Use of
Salicylates and Reye Syndrome
Surgeon Generals Advisory on the Use of Salicylates and Reye Syndrome Because the use of salicylates such as aspirin for ... advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox.* ... the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. ... The association of salicylates with Reye syndrome is based upon evidence from epidemiologic studies that are sufficiently ...
Salicylate Toxicity: Practice Essentials, Etiology and Pathophysiology, Epidemiology
... making salicylate toxicity an important cause of morbidity and mortality. (See Epidemiology. ... Salicylates are ubiquitous agents found in hundreds of over-the-counter (OTC) medications and in numerous prescription drugs, ... methyl salicylate (eg, oil of wintergreen; 98% salicylate), and Pepto-Bismol (236 mg of non-aspirin salicylate per 15 mL). ... Salicylate toxicity has been reported with the topical use of salicylate-containing teething gels in infants. [7] On the basis ...
Browsing by Subject "Salicylates"
DailyMed - PHYSOSTIGMINE SALICYLATE injection
Physostigmine Salicylate Injection is available in 2 mL ampules, each mL containing 1 mg of Physostigmine Salicylate in a ... PHYSOSTIGMINE SALICYLATE (UNII: 2046ZRO9VU) (PHYSOSTIGMINE - UNII:9U1VM840SP) PHYSOSTIGMINE SALICYLATE. 1 mg in 1 mL. ... PHYSOSTIGMINE SALICYLATE injection. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... Physostigmine Salicylate Injection is a derivative of the Calabar bean, and its active moiety, physostigmine, is also known as ...
Tea-Salicylate Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for Tea-Salicylate topical on WebMD including its uses, side effects and safety, interactions ... Tea-Salicylate Cream - Uses, Side Effects, and More. Generic Name(S): trolamine salicylate View Free Coupon * Uses ... Before using trolamine salicylate, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other salicylates ... Trolamine salicylate is used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). It ...
Acetaminophen/magnesium salicylate/pamabrom Side Effects: Common, Severe, Long Term - Drugs.com
Learn about the potential side effects of acetaminophen/magnesium salicylate/pamabrom. Includes common and rare side effects ... Acetaminophen / magnesium salicylate / pamabrom Side Effects. Applies to acetaminophen / magnesium salicylate / pamabrom: oral ... Salicylates can cause Reyes syndrome, a serious and sometimes fatal condition in children. ...
Phenyl Salicylate, 500 g | Flinn Scientific
Ammonium Salicylate pharmaceutical drugs and health products
Ammonium Salicylate indications and usages ATC and ICD codes, combinations with other active ingredients and trade names ... Ammonium Salicylate. Camphor. Ethyl Salicylate. Menthol. Methyl Salicylate Aspellin - Sanofi-Aventis. Radian B Pain Relief ... Ammonium Salicylate Salicyl-Vasogen - Pearson & Co.. Wulpyrin Ammonium Salicylate. Benzyl Nicotinate. Camphor. Capsicum ... Ammonium Salicylate. Camphor. Menthol. Methyl Salicylate. Salicylic Acid Radian B Muscle Lotion - Ransom. ...
Triethanolamine salicylate. - NAPRA
New insights into signaling pathways of salicylate and metalloporphyrins
... Aim of the study: I. Salicylate and heme oxygenase-1: ... Aim of the study: I. Salicylate and heme oxygenase-1: The adhesion molecule P-selectin has been shown to be a major determinant ... salicylate, heme oxygenase, metalloporphyrins, caspases, endothelial cells. Subjects:. 500 Natural sciences and mathematics. ... Different pharmacological agents including salicylate have been shown to inhibit IL-4-induced P-selectin expression in ...
Capsicum 0.32%, Methyl Salicylate 25% and Menthol 10% Analgesic Cream
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and...
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and ... Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and ... Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and ... Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and ...
Low Salicylate, Low Amine, Low Glutamate Recipes - Nourishing Hope
Rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary...
Rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary ... Rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary ... Rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary ... and sodium salicylate (NaSal). These types of self-assembly structures have viscoelastic properties, and the zero shear ...
Production of high BN alkaline earth metal single-aromatic ring hydrocarbyl salicylate-carboxylate - Patent US-6348438-B1 -...
An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose | Emergency Medicine Journal
Salicylate Free Fragrance?
I am looking for a fragrance that i can use everyday that is Salicylate free. Any ideas? Our reply Hi Sue, thanks for your ... Salicylate Free Fragrance?. by Sue (Australia) I am looking for a fragrance that i can use everyday that is Salicylate free. ... Thats a great question! I am not an expert on salicylate free products, but I have never been able to find a salicylate free ... Natural fragrances such as essential oils contain a lot of salicylates. I am not sure how you would find a salicylate free ...
Cari Produk methyl salicylate di Apotik online
The structures of salicylate surfactants with long alkyl chains in non-aqueous media<...
The structures of salicylate surfactants with long alkyl chains in non-aqueous media. In: Langmuir. 2013 ; Vol. 29, No. 48. pp ... The structures of salicylate surfactants with long alkyl chains in non-aqueous media. Langmuir. 2013 Dec 3;29(48):14763-14771. ... The structures of salicylate surfactants with long alkyl chains in non-aqueous media. / Lee, Chern Leing; Dowding, Peter J.; ... Lee, CL, Dowding, PJ, Doyle, AR, Bakker, KM, Lam, SS, Rogers, SE & Routh, AF 2013, The structures of salicylate surfactants ...
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug | The James Hutton Institute
TROLAMINE SALICYLATE
Salicylate may competitively inhibit prostaglandin formation. Salicylates antirheumatic (nonsteroidal anti-inflammatory) ... TROLAMINE SALICYLATE Created by admin. on Fri Jun 25 20:58:24 UTC 2021. , Edited by admin. on Fri Jun 25 20:58:24 UTC 2021. ... Its salts, the salicylates, are used as analgesics. Salicylic acid treats acne by causing skin cells to slough off more readily ... Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes.. ...
Phenyl Salicylate
Properties: White, small crystals or crystalline powder; pleasant aromatic odor and taste. d 1.25; mp 41-43°; bp12 173°. One gram dissolves in 6670 ml water, 6 ml alcohol, 1.5 ml benzene, 5 ml amyl alcohol, 10 ml liq paraffin, 4 ml almond oil. Sol in acetone, chloroform, ether, oils; very slightly sol in glycerol. Solubility at 25° in g/100 g: absolute ethanol 53; ethyl acetate 470; methyl ethyl ketone 620; toluene 460; Stoddard solvent 88; water less than 0.1%. Incompat. Bromine water, ferric salts; camphor, monobromated camphor, phenol, chloral hydrate, thymol or urethan in trituration. ...
Evaluation of methyl salicylate lures on populations of Typhlodromus pyri (Acari: Phytoseiidae) and other natural enemies in...
Evaluation of methyl salicylate lures on populations of Typhlodromus pyri (Acari: Phytoseiidae) and other natural enemies in ... Evaluation of methyl salicylate lures on populations of Typhlodromus pyri (Acari: Phytoseiidae) and other natural enemies in ... Evaluation of methyl salicylate lures on populations of Typhlodromus pyri (Acari: Phytoseiidae) and other natural enemies in ... Evaluation of methyl salicylate lures on populations of Typhlodromus pyri (Acari: Phytoseiidae) and other natural enemies in ...
Differential Growth Inhibition by the Aspirin Metabolite Salicylate in Human Colorectal Tumor Cell Lines: Enhanced Apoptosis in...
The effect of the aspirin metabolite salicylate on the growth of human colorectal tumor cell lines was determined. Salicylate ... Salicylate caused all cell lines to accumulate in G0-G1 and induced apoptosis in carcinoma and in vitro-transformed adenoma ... The ability of salicylate to induce cell cycle arrest and apoptosis and, in particular, the increased sensitivity of cells at ... In those adenoma lines that did show salicylate-induced apoptosis, the extent was considerably less than that in the more ...
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug<...
In rat H4IIE hepatoma cells, salicylate was the only drug tested that activated AMPK. Salicylate also reduced mTOR signalling, ... In rat H4IIE hepatoma cells, salicylate was the only drug tested that activated AMPK. Salicylate also reduced mTOR signalling, ... In rat H4IIE hepatoma cells, salicylate was the only drug tested that activated AMPK. Salicylate also reduced mTOR signalling, ... In rat H4IIE hepatoma cells, salicylate was the only drug tested that activated AMPK. Salicylate also reduced mTOR signalling, ...
Pfizer BioNTech Covid Vaccine and Salicylate increased, a phase IV clinical study of CDC and FDA data - eHealthMe
There is no Salicylate increased reported by people who get Pfizer BioNTech Covid Vaccine and have side effects. ... What is Salicylate Increased?. Salicylate increased is found to be associated with 22 drugs by eHealthMe. ... Salicylate increased in Johnson & Johnson COVID Vaccine Vaccine side effects by duration, gender, age and dose:. *Johnson & ... Pfizer BioNTech Covid Vaccine and Salicylate increased - a phase IV clinical study of CDC and FDA data Summary:. There is no ...
Phenyl Salicylate, 99%, Crystal, NF - Antec, Inc.
Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss :<b>John Coleman...
Salicylate is an aspirin-related compound, distinct from aspirin. It was selected for this study due to its dual effects as an ... Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss. John Coleman1, ... 7] Salicylate is chemically converted to dihydroxybenzoate (DHB) which is a specific scavenger of the (OH-) and DHB itself is ... 18] Salicylate may also inhibit NF-gamma B, a potential activator of inflammatory or cell death pathways, [19],[20] or induce ...
MethylMentholCholineSodiumSalicylicAspirin and other salicylatesToxicitySerumIngestion of aspirinDrugsAnalogues of the drugAnalgesicsConcentrationsTrolamineDosesInhibitFragranceReye'sPoisoningMedicationsLiquids2021MedicinalBenzylGLYCERINOxalatesTriethanolamineTopicalEvaluationResponsesDoseAdultDiagnosisEnzymeDerivativeEssential oilsAMPKChickenFoundSymptomsIllness
Methyl8
- Ingestion of topical products containing salicylates (eg, Ben-Gay, salicylic acid [keratolytic], oil of wintergreen or methyl salicylate), can cause severe salicylate toxicity. (medscape.com)
- According to published sources, one teaspoon of 98% methyl salicylate contains as much as 7000 mg of salicylate, the equivalent of nearly 90 baby aspirins and more than 4 times the potentially toxic dose for a child who weighs 10 kg. (medscape.com)
- [ 7 ] On the basis of a literature review, Greene et al estimated the allowable daily intake of methyl salicylate to be 11 mg/kg/d. (medscape.com)
- A comprehensive review of the existing medical literature on methyl salicylate poisoning has determined that it is a relatively common source of pediatric exposures. (medscape.com)
- Menthol and methyl salicylate are known as counterirritants. (blinkhealth.com)
- Further down the salicylic acid chain, Seqens EDS offers a comprehensive portfolio of Methyl Salicylate grades. (seqens.com)
- The glue vapors consisted of methyl- salicylate (119368), o-phenylphenol (90437), and various terpene or terpene derivative compounds. (cdc.gov)
- Menthol, Methyl Salicylate, Pine oil. (tongbos.com)
Menthol1
- Mint, mint oils, and menthol are all very high in salicylates so if you are sensitive or allergic to salicylates, it's necessary to leave mint and mint flavoring out of all personal care products. (cleure.com)
Choline4
- Physostigmine Salicylate Injection should not be used in the presence of asthma, gangrene, diabetes, cardiovascular disease, mechanical obstruction of the intestine or urogenital tract or any vagotonic state, and in patients receiving choline esters and depolarizing neuromuscular blocking agents (decamethonium, succinylcholine). (nih.gov)
- These drugs include magnesium choline salicylate, sodium salicy-late, and salicyl salicylate. (brainkart.com)
- b) in the case of choline salicylate, 435 mg. (gc.ca)
- Choline magnesium trisalicylate is in a class of nonsteroidal anti-inflammatory medications (NSAIDs) called salicylates. (epnet.com)
Sodium5
- Physostigmine Salicylate Injection is available in 2 mL ampules, each mL containing 1 mg of Physostigmine Salicylate in a vehicle composed of sodium metabisulfite 0.1%, benzyl alcohol 2.0% as a preservative in Water for Injection. (nih.gov)
- Rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary systems. (americanelements.com)
- This hypothesis was previously extended to wormlike micelles (WLM) of cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal). (americanelements.com)
- The efficacy of three different doses of sodium salicylate (SAL) in combination with one dose of N-acetylcysteine (NAC) to prevent noise-induced hearing loss was studied in chinchillas. (noiseandhealth.org)
- Le Gloss T Colour Gel 1253392 F: Aqua/Water/Eau Cetearyl Alcohol Cocamidopropyl Betaine Behentrimonium Chloride Propylene Glycol Amodimethicone, Sclerotium Gum Hc Blue 2 Isopropyl Alcohol Sodium Chloride Phenoxyethanol Parfum/Fragrance Ethanolamine, Citric Acid 2-Nitro-5-Glyceryl Methylaniline Cocos Nucifera Oil/Coconut Oil Trideceth-6 Lunalool Hexyl Cinnamal Chlorhexidine Digluconate Basic Brown 17, Benzyl Salicylate Benzyl Alcohol Limonene Cetrimonium Chloride Amyl Cinnamal Coumarin Citronellol Alpha-Isomethyl Ionone, F.I.L. (cub.com)
Salicylic3
- Salicylates are a group of chemicals derived from salicylic acid which are found naturally in certain plants and synthetically in products like medications, toothpaste, and food preservatives. (cleure.com)
- Benzyl salicylate is a synthetic chemical produced for industry from benzyl alcohol and salicylic acid, however it can be found naturally in some plants and plant extracts, such as hyacinth flower oil and ylang-ylang oil. (ecostore.com)
- Betaine salicylate combines perfectly the benefits of salicylic acid with the unique and gentle skin improvement properties,it can improve skin conditions wildly,that has antimicrobial properties and exfoliating ,moisturizing functions. (zhonglanindustry.com)
Aspirin and other salicylates3
- Aspirin and other salicylates are most often used to reduce pain , fever , and inflammation. (medlineplus.gov)
- But aspirin and other salicylates are usually safe and effective for adults when taken at the proper dose. (medlineplus.gov)
- These studies conducted by state health departments suggest an association between prior ingestion of aspirin and other salicylates and Reye syndrome. (cdc.gov)
Toxicity5
- Salicylate toxicity has been reported with the topical use of salicylate-containing teething gels in infants. (medscape.com)
- In a study of 599 cases of salicylate exposure in children less than 6 years old, the majority of children with signs of salicylate toxicity (metabolic acidosis, tachypnea) were exposed to liquid preparations. (medscape.com)
- The acid-base, fluid, and electrolyte abnormalities seen with salicylate toxicity can be grouped into phases. (medscape.com)
- Salicylate toxicity increases CNS utilization of glucose, serum glucose levels may not reflect CNS levels. (wikem.org)
- Salicylate toxicity is the great toxicologic mimicker! (emclerkship.com)
Serum2
- The nonacetylated salicylates are administered in doses up to 3-4 g of salicylate a day and can be monitored using serum salicy-late measurements. (brainkart.com)
- Loop Diuretics may increase the serum concentration of Salicylates. (genericpedia.com)
Ingestion of aspirin1
- Although concentrations of salicylate persist following ingestion of aspirin tablets, it has been shown that the majority of salicylate concentrations declined following ingestion of salicylate as acetylsalicylic powder. (medscape.com)
Drugs5
- The Surgeon General notes that the FDA will notify health professionals through its Drug Bulletin, will develop lay-language information for widespread distribution, and will take the steps necessary to establish new labeling requirements for drugs containing salicylates. (cdc.gov)
- It belongs to a class of drugs known as salicylates . (webmd.com)
- Salicylate increased is found to be associated with 22 drugs by eHealthMe. (ehealthme.com)
- All nonacetylated salicylates are effective anti-inflammatory drugs, although they may be less effective anal-gesics than aspirin. (brainkart.com)
- Treatment with mesalazine was initially started in 2015 before being withdrawn because of the inflammatory condition of the patient refractory to salicylates drugs. (lww.com)
Analogues of the drug1
- Here, we have gauged the contribution of these effects to control of hepatocyte glucose production, comparing salicylate with inactive hydroxybenzoic acid analogues of the drug. (hw.ac.uk)
Analgesics2
- However, the incidence of salicylate poisoning in children has declined because of reliance on alternative analgesics and the use of child-resistant containers. (medscape.com)
- Its salts, the salicylates, are used as analgesics. (ncats.io)
Concentrations1
- In one study, salicylate concentrations increased or changed insignificantly in 50% of patients who ingested tablets, but following powder ingestions, concentrations declined in 94% of cases. (medscape.com)
Trolamine1
- Trolamine salicylate is used to treat minor aches and pains of the muscles/joints (such as arthritis , backache, sprains). (webmd.com)
Doses1
- We found, for example, that H4IIE cells were exquisitely sensitive to uncoupling with modest doses of salicylate, which occurred on a similar time course to another anti-hyperglycaemic uncoupling agent 2,4-dinitrophenol, while there was no discernible effect at all of two salicylate analogues which are not anti-hyperglycaemic. (hw.ac.uk)
Inhibit4
- Different pharmacological agents including salicylate have been shown to inhibit IL-4-induced P-selectin expression in endothelial cells. (uni-muenchen.de)
- Salicylate may competitively inhibit prostaglandin formation. (ncats.io)
- This is in contrast to salicylates (eg, aspirin), which irreversibly bind to COX and inhibit production for the entire life of the cell, or acetaminophen, which inhibits COX centrally. (medscape.com)
- In particular, salicylate was found to potently activate AMPK, a kinase known to inhibit HAS2 activity, and caused a dose -dependent decrease of cell associated (intracellular and membrane -bound) as well as secreted hyaluronan , followed by the down-regulation of HAS2 and the induction of HYAL-2 and CD44 in metastatic breast cancer cells . (bvsalud.org)
Fragrance5
- Salicylate Free Fragrance? (mysensitiveskincare.com)
- I am looking for a fragrance that i can use everyday that is Salicylate free. (mysensitiveskincare.com)
- I am not an expert on salicylate free products , but I have never been able to find a salicylate free fragrance or perfume. (mysensitiveskincare.com)
- I am not sure how you would find a salicylate free fragrance or perfume. (mysensitiveskincare.com)
- This may be a good solution for you for a salicylate free fragrance for daily use! (mysensitiveskincare.com)
Reye's2
Poisoning4
- However, if you take too much, it can cause a serious and sometimes fatal condition called salicylate or aspirin poisoning. (medlineplus.gov)
- Salicylate ingestion continues to be a common cause of poisoning in children and adolescents. (medscape.com)
- Therefore, consider salicylate poisoning when topical herbal medicinal oil is involved. (medscape.com)
- A case of neonatal salicylate poisoning due to administration of this medicine as a colic reliever has been reported. (medscape.com)
Medications2
- Because the use of salicylates such as aspirin for children with influenza and chickenpox has been associated with Reye syndrome, the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. (cdc.gov)
- advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox. (cdc.gov)
Liquids1
- Salicylate is available for ingestion as tablets, capsules, and liquids. (medscape.com)
20211
- Retrieved September 29, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Benzyl-salicylate. (ecostore.com)
Medicinal1
- Salicylates are natural anti-inflammatory and medicinal substances found in plants, which are the active ingredient in aspirin. (mysensitiveskincare.com)
Benzyl4
- Benzyl Salicylate is used as an odor molecule in scented products. (wellacompany.com)
- Benzyl salicylate is an aromatic chemical, usually appearing as a clear liquid with a mild sweet floral odour. (ecostore.com)
- Benzyl salicylate: a survey of consumer patch-test sensitization. (ecostore.com)
- PubChem Compound Summary for CID 8363, Benzyl salicylate. (ecostore.com)
GLYCERIN1
- That being said, I do know of one brand of ***z-cleure-salicylate-free-glycerin-soap.shtml*** which is lightly scented. (mysensitiveskincare.com)
Oxalates1
- This is my favorite i f you're looking for a list of symptoms and which one of the many chemical constituents it might be, such as salicylates, oxalates, histamines, and more. (loricoultrup.com)
Triethanolamine1
- Triethanolamine salicylate. (napra.ca)
Topical1
- Salicylate is also available for topical application, in creams or lotions. (medscape.com)
Evaluation1
- We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). (unimi.it)
Responses2
- Aim of the study: I. Salicylate and heme oxygenase-1: The adhesion molecule P-selectin has been shown to be a major determinant of inflammatory responses. (uni-muenchen.de)
- Using the salicylate-induced model of tinnitus and hyperacusis, we found that long-latency (>10 ms) sound-evoked response components in both the brain regions were significantly enhanced after salicylate administration, while the short-latency responses were reduced, likely reflecting cochlear hearing loss. (cdc.gov)
Dose2
- Salicylate showed dose-dependent inhibitory effects on all of the cell lines (IC 50 , 1.65 ± 0.36 to 7.38 ± 1.08 m m ), yet carcinoma and in vitro -transformed adenoma cell lines were more sensitive than adenoma cell lines. (aacrjournals.org)
- Finally, we demonstrate that salicylate results in an increase in corticosterone level in a dose-dependent manner consistent with the notion that stress may interact with hearing loss in tinnitus and hyperacusis development. (cdc.gov)
Adult1
- C.09.032 (1) Subject to subsections (2) and (3) and section C.09.035, a salicylate product in the form of a tablet, capsule or other solid dosage form intended for oral administration shall contain one adult standard dosage unit of a salicylate per individual dosage form. (gc.ca)
Diagnosis1
- Dramatic reversal of the effects of anticholinergic symptoms can be expected in minutes after the intravenous administration of Physostigmine Salicylate Injection, if the diagnosis is correct and the patient has not suffered anoxia or other insult. (nih.gov)
Enzyme1
- In a sub-panel of analogues, salicylate alone reduced promoter activity of the key gluconeogenic enzyme glucose 6-phosphatase and suppressed basal glucose production in mouse primary hepatocytes. (hw.ac.uk)
Derivative1
- Physostigmine Salicylate Injection is a derivative of the Calabar bean, and its active moiety, physostigmine, is also known as eserine. (nih.gov)
Essential oils1
- Natural fragrances such as essential oils contain a lot of salicylates. (mysensitiveskincare.com)
AMPK3
- In rat H4IIE hepatoma cells, salicylate was the only drug tested that activated AMPK. (hw.ac.uk)
- Both salicylate and 2,6 dihydroxybenzoic acid suppressed TNFα-induced IκB degradation, and in genetic knockout experiments, we found that the effect of salicylate on IκB degradation was AMPK-independent. (hw.ac.uk)
- Previous data also identified AMPK-independent regulation of glucose but we found that direct inhibition of neither NF-κB nor mTOR signalling suppressed glucose production, suggesting that other factors besides these cell signalling pathways may need to be considered to account for this response to salicylate. (hw.ac.uk)
Chicken1
- Egg-Free Chicken Nuggets GFCFSF/Low Oxalate/Low Salicylate, Egg-Free, and Nut-Free Use white vinegar for low salicylate. (nourishinghope.com)
Found2
- Salicylates are a type of drug found in many over-the-counter and prescription medicines. (medlineplus.gov)
- Salicylate is a natural substance thatcan be found in many foods, such as almonds, tomatoes, grapes and apples. (medguidance.com)
Symptoms1
- If excessive symptoms of salivation, emesis, urination and defecation occur, the use of Physostigmine Salicylate Injection should be terminated. (nih.gov)
Illness1
- CDC, on the basis of its review of the available data and the recommendations of an advisory panel on February 12, 1982, stated that 'until definitive information is available, CDC advises physicians and parents of the possible increased risk of Reye syndrome associated with the use of salicylates for children with chickenpox and influenza-like illness' (3). (cdc.gov)