The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
Salts and esters of gentisic acid.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.
A plant genus of the family ERICACEAE. The common name of "wintergreen" is also used for PYROLA and "snowberry" is also used for SYMPHORICARPOS.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.
Places for cultivation and harvesting of fish, particularly in sea waters. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.
A plant genus of the family CORNACEAE. It is widely cultivated for the attractive flowers.
A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.

Perinatal nephropathies. (1/1030)

The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation.  (+info)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)

Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate.  (+info)

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.  (+info)

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.  (+info)

NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)

Two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10. While nahG resides in the same transcriptional unit as the meta-cleavage pathway genes, forming the naphthalene degradation lower pathway, nahW is situated outside but in close proximity to this transcriptional unit. The nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism. Both genes, nahG and nahW, have been cloned in Escherichia coli JM109. The overexpression of these genes yields peptides with apparent molecular masses of 46 kDa (NahG) and 43 kDa (NahW), respectively. Both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates, and chlorosalicylates. However, the relative rates by which the substituted analogs are transformed differ considerably.  (+info)

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)

1. The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the activation of NF-kappaB elicited by tumour necrosis factor-alpha (TNF-alpha) on human umbilical vein endothelial cells (HUVEC) was tested. 2. The expression of the mRNA of vascular cell adhesion molecule-1 (VCAM-1) was studied as an example of a gene the expression of which is regulated by NF-kappaB. To extend these findings to other systems, the induction of nitric oxide synthase in rat adherent peritoneal macrophages was studied. 3. Both HTB and triflusal were more potent than aspirin or salicylate as inhibitors of the nuclear translocation of NF-kappaB. The calculation of the IC50 values showed approximately 2 mM for HTB, 4 mM for aspirin and >4 mM for salicylate. 4. Comparison of the potency of these compounds on VCAM-1 mRNA expression showed complete inhibition by both triflusal and HTB at a concentration of 4 mM whereas aspirin and salicylate produced only 36-43% inhibition at the same concentration. 5. Inhibition of NF-kappaB activation was also observed in rat peritoneal macrophages stimulated via their receptors for the Fc portion of the antibody molecule with IgG/ovalbumin immune complexes. This was accompanied by a dose-dependent inhibition of nitrite production by the L-arginine pathway via iNOS. IC50 values for this effect were 1.13+/-0.12 mM (triflusal), 1.84+/-0.34 (HTB), 6.08+/-1.53 mM (aspirin) and 9.16+/-1.9 mM (salicylate). 6. These data indicate that the incorporation of a 4-trifluoromethyl group to the salicylate molecule strongly enhances its inhibitory effect on NF-kappaB activation, VCAM-1 mRNA expression and iNOS induction, irrespective of the presence of the acetyl moiety involved in the inhibition of cyclo-oxygenase.  (+info)

Reye's syndrome in the United States from 1981 through 1997. (7/1030)

BACKGROUND: Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella. Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome. METHODS: To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and risk factors for poor outcomes, we analyzed national surveillance data collected from December 1980 through November 1997. The surveillance system is based on voluntary reporting with the use of a standard case-report form. RESULTS: From December 1980 through November 1997 (surveillance years 1981 through 1997), 1207 cases of Reye's syndrome were reported in patients less than 18 years of age. Among those for whom data on race and sex were available, 93 percent were white and 52 percent were girls. The number of reported cases of Reye's syndrome declined sharply after the association of Reye's syndrome with aspirin was reported. After a peak of 555 cases in children reported in 1980, there have been no more than 36 cases per year since 1987. Antecedent illnesses were reported in 93 percent of the children, and detectable blood salicylate levels in 82 percent. The overall case fatality rate was 31 percent. The case fatality rate was highest in children under five years of age (relative risk, 1.8; 95 percent confidence interval, 1.5 to 2.1) and in those with a serum ammonia level above 45 microg per deciliter (26 micromol per liter) (relative risk, 3.4; 95 percent confidence interval, 1.9 to 6.2). CONCLUSIONS: Since 1980, when the association between Reye's syndrome and the use of aspirin during varicella or influenza-like illness was first reported, there has been a sharp decline in the number of infants and children reported to have Reye's syndrome. Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome.  (+info)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)

OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels.  (+info)

Bismuth subsalicylate, sold under the brand name Pepto-Bismol, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea. It is also commonly known as pink bismuth. Bismuth subsalicylate has the empirical chemical formula of C7H5BiO4, and it is a colloidal substance obtained by hydrolysis of bismuth salicylate (Bi(C6H4(OH)CO2)3). The actual structure[clarification needed] is unknown and the formulation is only approximate. As a derivative of salicylic acid, bismuth subsalicylate displays anti-inflammatory and bactericidal action. It also acts as an antacid. There are some adverse effects. It can cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in saliva and the colon to form bismuth sulfide. Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless. Long-term use (greater than 6 weeks) may lead ...
2-Trifluoromethylbenzoic acid, 3,5-difluorophenyl ester | C14H7F5O2 | CID 530822 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
An original, highly sensitive and specific high performance liquid chromatographic method has been developed for the measurement of aspirin and salicylate in plasma. Minimum concentrations of 10 xg/L (aspirin) and 0.5 mg/L (salicylate) can be measured using 1 ml of plasma. After collection, plasma is first treated with physostigmine sulfate to inhibit enzymatic hydrolysis of aspirin to salicylate. Maximal recovery is achieved using an acid extraction into anhydrous diethyl ether with a subsequent drying-down step in an iced water bath. Aspirin and salicylate are separated by elution with a mixture of methanol, 1-butanol, orthophosphoric acid, and water on a reversed-phase octadecyl silane column at 47°C and detected at 234 nm by ultraviolet absorption. Quantitation is achieved using the peak height ratio of aspirin and salicylate to internal standard (m-anisic acid). The assay has been used for the study of simultaneous aspirin and salicylate pharmacokinetics after a single oral dose of 100 mg ...
Anyone can be, or become, sensitive to anything, including salicylates. It happens when people or over exposed or continually exposed; however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. It also tends to affect older adults or people who have worsening asthma problems, and, yet, the worsening asthma problems may be related to continual exposure to salicylates. So, its a vicious cycle as your health continues to deteriorate, and you experience more and more health problems.. If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. For more information on salicylates in food or how to conduct a test see the How Do I Get More Information?section at the bottom of this article. If you have salicylate problems and remove them from your life, your ...
Use only if your formulation does NOT contain salicylates. Pepto-Bismol® should not be used in cats since it contains salicylates, the active ingredient in aspirin. Cats are very sensitive to aspirin so it should be avoided. WARNING - PLEASE NOTE THAT THE NEW FORMULATIONS OF KAOPECTATE MAY ALSO HAVE SALICYLATES. Do not use if your formulations lists salicylates as an active ingredient. Any vomiting or diarrhea that persists for more than 24 hours needs your veterinarian's attention. ...
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Toxicokinetics The 17 salicylate substances assessed in the RIFM review indicate consistent metabolism by hydrolysis to form salicylic acid and the alcohol of the corresponding side chain. This pattern of metabolism is consistent with information on other esters which are hydrolysedin vivoby carboxylesterases or esterases, especially the A-esterases. In vivo metabolic data are available for methyl salicylate and one human metabolism study is available on phenyl salicylate. Carboxylesterases show extensive tissue distribution with respect to hydrolysis of methyl salicylate. In vitro studies demonstrate greatest activity in the liver, but also extensive activity in the intestines, kidney, pancreas and spleen. Both the liver and intestines can contribute to the pre-systemic hydrolysis of salicylates. Oral consumption of 0.42 mL methyl salicylate by human volunteers resulted in the rapid appearance of salicylic acid in the plasma. At 15 and 90 minutes post administration, salicylic acid ...
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM). Salsalate treatment increased oxygen consumption, lowered fasting glucose, improved glucose tolerance and led to an ∼55% reduction in liver lipid content; effects observed in both WT and AMPK β1KO mice. To explain these AMPK-independent effects, it was found that salicylate increases oligomycin-insensitive respiration (state 4o) and directly increases mitochondrial proton conductance at clinical concentrations. This ...
It is important to note that cats are more sensitive to toxicity with salicylates and should never be given this medication.. Signs and symptoms of toxicity: vomiting, diarrhea, melena (dark, tarry stool), abdominal pain, pale gums, altered mental status, difficulty breathing, and dehydration. While some signs may appear within several hours of ingestion, it may take several days for other signs to appear.. Toxic consumption: Do not exceed dosing recommendations from your veterinarian. Report all incidents of accidental ingestion immediately.. References ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The salicylate assay aids in the diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to insure appropriate therapy. Salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic acid (aspirin) is the most commonly used salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. For this reason, salicylates are often seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Prompt recognition and management are necessary to avoid serious consequences. ...
Bismuth by Jamp Pharma: Bismuth subsalicylate belongs to a class of medications called antacids and adsorbents. It is used to help relieve heartburn, indigestion, upset stomach, nausea, and diarrhea. How bismuth subsalicylate works is not completely understood, but it is thought to work by coating the stomach and intestines (protecting them from stomach acid), by reducing inflammation in the stomach, and by killing certain bacteria.
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Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. Early on these may be subtle while larger doses may result in fever. Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. Excess doses can be either on purpose or accidental. Small amounts of oil of wintergreen can be toxic. Diagnosis is generally based on repeated blood tests measuring aspirin levels and blood gases. While a type of graph has been created to try to assist with diagnosis, its general use is not recommended. In overdose maximum blood levels may not occur for more than 12 hours. Efforts to prevent poisoning include child-resistant packaging and a lower number of pills per package. Treatment may include ...
OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation end products (AGEs) that have been implicated in diabetic vascular complications. RESEARCH DESIGN AND METHODS Participants were from the Targeting Inflammation Using Salsalate for Type 2 Diabetes (TINSAL-T2D) study, which examined the impact of salsalate treatment on hemoglobin A1c (HbA1c) and a wide variety of other parameters. One hundred eighteen participants received salsalate, 3.5 g/day for 48 weeks, and 109 received placebo. Early glycation product levels (HbA1c and fructoselysine [measured as furosine]) and AGE levels (glyoxal and methylglyoxal hydroimidazolones [G-(1)H, MG-(1)H], carboxymethyllysine [CML], carboxyethyllysine [CEL], pentosidine) were measured in patient serum samples. RESULTS Forty-eight weeks of salsalate treatment lowered levels of HbA1c and serum furosine (P
TY - JOUR. T1 - Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. AU - Li, Geming. AU - Sha, Su Hua. AU - Zotova, Elena. AU - Arezzo, Joseph. AU - Van De Water, Thomas R.. AU - Schacht, Jochen. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Salicylate has recently been demonstrated to protect against the auditory and vestibular side effects of aminoglycoside antibiotics. Similarities in the toxic mechanisms suggest salicylate as a treatment strategy to prevent the ototoxic side effects of cisplatin (CDDP). We first tested protection of the inner ear in Wistar rats receiving a single infusion of 16 mg CDDP/kg body weight with or without treatment with 100 mg/kg salicylate (bid) for 5 days beginning one day before the CDDP infusion. Cisplatin induced a threshold shift of more than 30 dB (at 14 kHz; measured by auditory evoked brain stem response) that was significantly reduced by salicylate. We then examined the protective potential of ...
It is concluded that the absorption of 2-ethylhexyl salicylate via the dermal route is very low (3%), while it is well absorbed via the oral route (100% absorption assumed). Following absorption, 2-ethylhexyl salicylate is metabolized to salicylic acid and 2-ethylhexanol rapidly. Salicylic acid is mainly excreted by renal excretion as an unchanged chemical entity or after conjugation with glycine as salicyluric acid. 2-Ethylhexanol is metabolized following metabolic pathways of alcohols with its degradation products mainly excreted in respiratory CO2, via faeces and urine. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (salicylic acid and 2-ethylhexanol) with established elimination routes. Due to low vapor pressure (1.8E-4hPa at 20 °C, Symrise) and high boiling point (, 300 °C, Intertek ASG), the inhalation route is not considered to be a relevant exposure route to human for 2-ethylhexyl salicylate. ...
Salicylates are a group of drugs, including aspirin, that are used to relieve pain and inflammation and to reduce fever. Salicylate testing may be used to detect a high level of salicylate in the blood and help diagnose an overdose (salicylate poisoning).
Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Methyl salicylate topical may also be used for purposes not listed in this medication guide.
Methyl Salicylate containing medications, Methyl Salicylate indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from Drugs-about.com
The interference of analgesics with ACTs (Coartem, Corsucam…) has barely been studied in clinical trials.. Aspirin (acetylsalicylic acid) is sold over the counter in Africa and appears to be the first line treatment when children or adults have fever. Chronic salicylate poisoning by overdosis is common. Many children brought to a hospital in Africa have a high load of salicylic acid in their blood. Paracetamol is also of common use.. In all children admitted to Kilifi District Hospital between July and September, 1994, who had a positive blood film for Plasmodium falciparum, and one or more of coma, prostration, or respiratory distress salicylate concentrations were measured. (English M1, et al., Lancet. 1996 347(9017):1736-7). Data were available for 143 children with initial primary diagnoses of severe malaria. 129 had detectable (,l mg/dL) salicylate. Six of these had salicylate concentrations of 20 mg/dL or higher. All six had neurological impairment and metabolic acidosis and four were, ...
To address toxicological endpoints as part of the REACH registration of Benzyl Salicylate (Target Substance) it is proposed to read-across to Cyclohexyl Salicylate, Ethylhexyl salicylate and Methyl salicylate (Source Substances). The use of read-across works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. The Target Substance and Source Substances have been characterised using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling, it can be seen that the substances share structural similarities and also mechanistic action similarities which are both general and endpoint specific. For classification and labelling purposes this indicates that the structural analogues are relatively harmless and would not be classified in accordance with Regulation (EC) No 1272/2008 (CLP). The registration substance is considered to have similar properties and is therefore not classified in accordance with CLP. ...
SALICYLIC ACID 477 Methyl Salicylate. This is also known as artificial oil of wintergreen, and is obtained by the interaction of methyl alcohol and salicylic acid. It is a colourless liquid, having a characteristic, aromatic odour and a sweetish, warm, aromatic taste. It is slightly soluble in water, and freely soluble in alcohol, ether, chloroform, glacial acetic acid or carbon bisulphide. Methyl salicylate is taken accidentally, suicidally or to procure abortion, and causes symptoms of acute gastro-intestinal irritation resembling those of poisoning by salicylic acid, followed occasionally by death. About an ounce of methyl salicylate proved fatal to an adult woman in 15 hours42 and a dose of 50 ml. of methyl salicylate caused the death of a middle aged woman hi about 11 hours.43 Doses of 10 cc. to 12 cc. of methyl salicylate have killed children.44 On the other hand, a child, aged 2 years, recovered after swallowing an ounce.45 The treatment consists in the washing out of the stomach and ...
Choline salicylate + cetalkonium chloride is used in the treatment of .get complete information about choline salicylate + cetalkonium chloride including usage, side effects, drug interaction, expert advice along with medicines associated with choline salicylate + cetalkonium chloride at 1mg.com
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Definition of salicylate in the Definitions.net dictionary. Meaning of salicylate. What does salicylate mean? Information and translations of salicylate in the most comprehensive dictionary definitions resource on the web.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.. Check the label of all over-the-counter (OTC), nonprescription, and prescription medicines you now take. If any of them contain acetaminophen, aspirin, other salicylates such as bismuth subsalicylate (e.g., Pepto Bismol) or magnesium salicylate (e.g., Nuprin Backache Caplets), or salicylic acid (present in some shampoos and skin products), check with your health care professional. Using any of them together with this medicine may cause an overdose.. Do not drink alcoholic beverages while taking this medicine. Stomach problems may be more likely to occur if you drink alcoholic beverages while you are taking aspirin or ibuprofen. Also, liver damage may be more likely to occur if you drink large amounts of alcoholic beverages while you are taking acetaminophen.. If you think that you or anyone else may have taken an overdose of this ...
Summary of evidence. Traveler setting: Prevention of TD is challenging because of the ubiquitous exposures to individuals through contaminated food, water, and generally unhygienic conditions among much of the developing world. Travelers are frequently counseled on preventive risk behaviors, but despite a travelers best attention to such recommendations, evidence is lacking that such precautions have any protective effect (188). Although vaccines for many of the agents commonly associated with TD are under development, these are considered a long-term solution and might likely suffer from the lack of utilization as has been seen with most travel-associated vaccines (202, 203, 204,205, 206). Alternative primary prevention strategies such as BSS, probiotics, and antibiotics have been evaluated and are considered here.. Bismuth subsalicylate. BSS has been shown in several studies to reduce the frequency of TD when used during period of risk for 3 weeks (207, 208, 209). While the salicylate portion ...
At first glance, bismuth doesnt seem to be particularly extraordinary. Element number 83 is probably most likely encountered in the compound bismuth subsalicylate (C7H5BiO4), used in gastro-intestinal remedies such as Pepto Bismol. The pure metal is also gaining popularity as a more environmentally friendly (and much more expensive) alternative to lead in hunting ammunition. In…
Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. Hemodialysis. For chronic salicylate toxicity,
Salsalate is insoluble in acid gastric fluids (,0.1 mg/ml at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body: its half-life is about one hour. About 13% is excreted through the kidneys as a glucuronide conjugate of the parent compound, the remainder as salicylic acid and its metabolites. Thus, the amount of salicylic acid available from salsalate is about 15% less than from aspirin, when the two drugs are administered on a salicylic acid molar equivalent basis (3.6 g salsalate/5 g aspirin ...
Continuous decline in cognitive performance accompanies the natural aging process in humans, and multiple studies in both humans and animal models have indicated that this decrease in cognitive function is associated with an age-related increase in oxidative stress. Treating aging mammals with exogenous free radical scavengers has generally been shown to attenuate age-related cognitive decline and oxidative stress. I assessed the effectiveness of the superoxide dismutase/catalase mimetics EUK-189 and EUK-207 on age-related decline in cognitive function and increase in oxidative stress. C57/BL6 mice received continuous treatment via osmotic minipumps with either EUK-189 or EUK-207 for 6 months starting at 17 months of age. At the end of treatment, markers for oxidative stress were evaluated by analyzing levels of free radicals, lipid peroxidation and oxidized nucleic acids in brain tissue. In addition, cognitive performance was assessed after 3 and 6 months of treatment with fear conditioning. ...
These results indicate that pretreatment of rats with the synthetic catalytic scavenger of ROS, EUK-134, prevents oxidative stress and produces a significant degree of protection against the pathological manifestations of KA-induced seizure activity in hippocampus and piriform cortex. Although numerous studies have suggested that ROS are critically involved in excitotoxicity (see refs. 5, 30, and 31 for reviews), very few studies have demonstrated convincingly, in an in vivo excitotoxic model, a causal relationship between increased production of ROS and neuronal damage (7, 32). A clear demonstration of the crucial role of ROS in excitotoxicity should include: (i) evidence for increased production of ROS specifically in neuronal populations at risk with excitotoxicity before overt signs of neuronal damage and (ii) evidence that manipulations aimed at preventing ROS accumulation reduce neuronal damage without interfering with excitatory amino acid receptor functions. The former has been difficult ...
Buy High Purity Methyl Salicylate | Medical Grade For Sale Online In USA | Oil of Wintergreen | For Topical Pain Relief Ointments | 100ml $16.00 | Methyl Ester Of Salicylic Acid | Formula C8H8O3 | Synthetic Form | CAS 119-36-8 | Weight 152.15 | Bulk Supplier & Distributor
Triflusal Triflusal Systematic (IUPAC) name 2-acetyloxy-4-(trifluoromethyl)benzoic acid Identifiers CAS number  ? ATC code B01AC18 PubChem 9458 Chemical
After an excitotoxic lesion in the postnatal cortex, glial NF-κB is consistently activated at 10 hours after injury, showing its peak at day 1.4 Therefore, when triflusal is orally administered 8 hours after the NMDA injection, it preferentially targets NF-κB induced in glial cells, as the inducible neuronal NF-κB is starting to decrease when triflusal reaches the brain. Glial NF-κB is probably induced by injury-related signals that occur in the degenerating area. They may include reactive oxygen species, produced in excitotoxically damaged cells,44 and the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α, which are expressed by neurons and glial cells in this excitotoxic lesion model, showing a peak of expression at 10 hours after injury.45 On activation, NF-κB translocates to the cell nucleus and modulates the expression of several genes implicated in the development of the glial and inflammatory responses. Target genes containing a NF-κB-binding site include the ...
Temporarily relieves minor aches and pains. IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains,...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
Looking for TCI AMERICAS 3-Methylsalicylic Acid,25g (29LD24)? Graingers got your back. Price:$22.75. Easy ordering & convenient delivery. Log-in or register for your pricing.
Salicylates: The salts, esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
The clinical manifestations and management of all salicylate intoxications are similar. An overview of salicylate intoxication in children and adolescents will be presented here. General issues relating to the clinical management of drug intoxication
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Bismuth subsalicylate is an antacid and anti-diarrhea medication. Bismuth subsalicylate is used to treat diarrhea, nausea, heartburn, indigestion, and upset stomach. Bismuth subsalicylate may also be used for purposes not listed in this medication guide.
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Leader Stomach Relief with NDC 70000-0439 is a a human over the counter drug product labeled by Cardinal Health. The generic name of Leader Stomach Relief is bismuth subsalicylate.
Stomach Relief with NDC 55319-736 is a a human over the counter drug product labeled by Family Dollar (family Wellness). The generic name of Stomach Relief is bismuth subsalicylate.
The therapeutic effect of bismuth subsalicylate BSS Pepto-Bismol in Clostridium difficile colitis was studied in golden Syrian hamsters. C. difficile was fed to the hamsters by orogastric intubation 2-3 days after their arrival. Clindamycin 1.5 mg per animal was given intraperitoneally 4 days l
Bismuth subsalicylate can be useful in the prevention and treatment of travelers diarrhea. Antibiotic prophylaxis is not routinely recommended. Treatment is typically with a fluoroquinolone or azithromycin. One recommended fluid replacement is: 1L of water with 1/2 tsp salt, 1/2 tsp baking soda, and 4 tbsp sugar ...
Bismuth Subsalicylate Suspension official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Learn everything you need to know about bismuth subsalicylate (kaopectate) and its nursing considerations incluing classification and common side effects
A Major Drug Interaction exists between bismuth subsalicylate and Diamox. View detailed information regarding this drug interaction.
High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion products of otoacoustic emission (DPOAE). These results suggest that ICA-105665
Thiosalicylic acid sodium salt/AFI134236 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Benzyl Salicylate (benzyl ortho hydroxy benzoate) is an almost colourless liquid that has a mild balsamic, sweetly floral note possessing excellent blending capabilities. Often used ~like foundation is for make-up~ as a base for heavy florals such as ylang, gardenia, jasmine, lily etc. It is also used in functional products such as soap, shampoo and fabric softener. Along with Methyl Salicylate, salicylates turn the most banal floral composition into a real perfume, with majestic weight and sweep divulges Luca Turin. However some people are anosmic to it, including some perfumers. Guy Robert could not smell benzyl salicylate at all, but could instantly recognize its presence in perfume: I recognize it as if it were a friend seen from behind in a crowd, by the cut of his shoulders. Indeed in the words of nose Bernand Chant it produces a diffusing, blooming effect very pleasing to the public. Many orchid fragrances are built on salicylates, while the mysterious emerald glow of the vintage Je ...
This study was designed to determine the dose of salicylate necessary to produce substantial antipyresis, and to determine the relationship between the response to salicylate and prostaglandin infused into the same region of the preoptic area of the rabbit. The effect of preoptic infusions of three doses of sodium salicylate, or a control solution, on the fever produced by an intravenous injection of endogenous pyrogen was measured. The pyrogenic response to prostaglandin E1 injected into the same preoptic sites in the same rabbits was also monitored. The results showed that the 50 μg/μL per hour dose of salicylate did not produce significant antipyresis but that the 100 and 200 μg/μL per hour doses did. The results also showed a significant correlation between the magnitude of fever produced by prostaglandin E1 and the magnitude of antipyresis produced by sodium salicylate at a particular site. Those sites at which infusion of salicylate produced the most effective antipyresis were also the ones at
If youre interested in forensic toxicology and are trying to determine the presence of salicylate by using a visual colorimetry, then look no further. This indepth and compelling video takes you into world of salicylate determination. Salicylate determination with visual colorimetry, Part I Using iron(III) nitrate to determine salicylate concentration in standardized salicylate solutions and urine. You can actually use any iron(III) salt, such as ferric chloride, ferric ammonium sulfate, and so on. Concentration is not critical
3. Helidac (Bismuth Subsalicylate/Metronidazole/Tcn) Bismuth subsalicylate is a mild antibiotic. Helitene (Collagen Topical) Helixate FS (Antihemophilic Factor) Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot
Take this medicine by mouth. Follow the directions on the label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be used in children as young as 12 years for selected conditions, precautions do apply.. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
This medication is typically used 4 times a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Generally, it is used only as needed. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food. It is recommended to drink plenty of water while using this medication. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
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Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness ...
Looking for online definition of phenyl salicylate in the Medical Dictionary? phenyl salicylate explanation free. What is phenyl salicylate? Meaning of phenyl salicylate medical term. What does phenyl salicylate mean?
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Salicylate is produced by many plants and microbes and is widely distributed in nature. It has a variety of biological activities, most notably its role in human medicine as a member of an important anti-inflammatory drug class. Salicylate acts as a regulatory molecule for bacteria (49). The biosynthesis and natural degradation pathways of this simple organic molecule have been well studied. In this work, we have identified a salicylate degradation cluster (sdgABCDEFGHR) in Streptomyces sp. strain WA46 and shown that salicylate is initially converted to gentisate via salicylyl-CoA and gentisyl-CoA (Fig. 2 and 3A). Salicylate is presumably converted to salicylyl-CoA via salicylyl-AMP by the action of SdgA and SdgB. AMP ligases are key components in the biosynthesis of antibiotics and siderophores, in which specific substrates are activated by AMP addition (12, 20, 34, 50, 53); the activated adduct binds to the thiol group of biosynthetic enzymes or to an acyl carrier protein. We were unable to ...
Several embryotoxic agents, which includes sodium salicylate, were reported to induce vertebral variations in the form of supernumerary ribs (SNR) when administered to pregnant rodents. Because the biological significance of SNR in toxicological studies is still a matter of debate, we investigated the molecular basis of this defect by analyzing the possible involvement of Hox genes, known to specify vertebrae identity. Sodium salicylate (300mg/kg) was administered to pregnant rats on gestational day 9 (GD 9). On GD 13, the expression of several Hox genes, selected according to the position of their anterior limit of expression, namely upstream (Hoxa9), at the level (Hoxa10) and downstream (Hoxd9) to the morphological alteration, were analyzed. Posterior shifts in the anterior limit of expression of Hoxa10 and Hoxd9 were observed following exposure to salicylate, which could explain an effect at the level of the axial skeleton. This finding suggests that the appearance of ectopic ribs can be ...
Prevention of Human Immunodeficiency Virus Type 1 Trans-mission by Pharmaceuticals Targeted to Host Proteins Re-quired for Virus Infection? Consideration of Farnesyl Thiosalicylic Acid, a Ras Inhibitor Abstract.
TY - JOUR. T1 - Salicylate degradation by a cold-adapted Pseudomonas sp. AU - Ahn, Eunsol. AU - Choi, Ki Young. AU - Kang, Beom Sik. AU - Zylstra, Gerben J.. AU - Kim, Dockyu. AU - Kim, Eungbin. N1 - Publisher Copyright: © 2017, Springer-Verlag Berlin Heidelberg and the University of Milan. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Pseudomonas sp. strain MC1 was characterized as a cold-adapted, naphthalene-degrading bacterium that is able to grow in a broad temperature range of 5-30°C. MC1 harbors a catabolic plasmid, designated pYIC1, which is almost identical to the archetypal NAH7 plasmid from the mesophilic bacterium Pseudomonas putida G7. On pYIC1, the catabolic genes for naphthalene degradation are clustered in two operons: nahAa-Ab-Ac-Ad-B-F-C-Q-E-D encoding the conversion of naphthalene to salicylate, and nahG-T-H-I-N-L-O-M-K-J encoding the conversion of salicylate through meta-cleavage pathway to pyruvate and acetyl CoA. NahH, ...
The chemical formula for sodium salicylate is C7H5NaO3. All of the numbers in the chemical formula for sodium salicylate are subscript numbers in accordance with standard chemical formula...
TY - JOUR. T1 - Salicylate uniquely induces a 27-kDa protein in tubercle bacillus. AU - Sun, Zhonghe. AU - Cheng, Shao Ji. AU - Zhang, Hao. AU - Zhang, Ying. PY - 2001/9/25. Y1 - 2001/9/25. N2 - Salicylate was found to uniquely induce a 27-kDa protein in Mycobacterium tuberculosis complex organisms but not in Mycobacterium smegmatis or Escherichia coli. The structural analogue antitubercular para-amino-salicylate also induced the 27-kDa protein but to a somewhat lower level than salicylate. Other structural analogues such as benzoic acid and acetyl salicylic acid (aspirin) did not induce the 27-kDa protein. Western blot analysis indicated that the 27-kDa protein was localized mainly in the cytoplasm. The 27-kDa protein was not expressed at different growth phases in the absence of salicylate. The 27-kDa protein was identified as a putative benzoquinone methyltransferase (Rv0560c), which has several homologues in the M. tuberculosis genome. The cloned 27-kDa gene was found to express ...
5-AMINO-3-SULFOSALICYLIC ACID | C7H7NO6S | CID 22574 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
A bismuth compound, bismuth oxychloride, is used in some cosmetics to give either a matte or a shiny finish depending on particle size. Other bismuth compounds, bismuth(III) oxide and bismuth subcarbonate, are used in fireworks to give crackling effects. These compounds are formed into granules, the rapid combustion of which gives the crackling effect.. Bismuth-containing compounds are also found in medicines to treat stomach aches and diarrhoea. The best-known example is Pepto-Bismol (bismuth subsalicylate), an antacid.. Remember, you can keep track of all of the previous entries in this series on the site here, or on the Royal Society of Chemistrys dedicated page.. ...
If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Minocin . Check with your doctor if you have questions ...
If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Minocycline. Check with your doctor if you have questions ...
American Diabetes Association and the American Dietetic CEREALS/GRAINS/PASTA *Bran cereals concentrated (such as Bran Buds All Bran) Ingredient List: Active Ingredient: Bismuth subsalicylate 525 mg Inactive Ingredients: benzoic acid or pharmacist before use if you are taking any drug for: anticoagulation (thinning the blood) diabetes gout arthritis. Blood Glucose and Hormones - Insulin and Glucagon Antagonistic hormones 3. Cure Pancreatic Cancer Ribbon medication Diabetes Causes Fatigue :: Type 2 Diabetes Research For Cures - The 3 Step Trick that Reverses Diabetes Permanently in type 1 diabetes and gluten free diet As Little as 11 Days. en la historia evolutiva de la enfermedad al curar Health Concern On diagnosis or treatment.. Learn about their use side effects and safety warnings. There are several different types of rice including long-grain basmati black rice white rice and diabetes Brown Rice: Health Benefits & Nutrition Anti-phospho-Insulin Receptor Antibody clone 21G12 is an antibody ...
Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT
A recently published report describes the case of a 62-year-old female patient with underlying cirrhosis who experienced coagulopathy secondary to bismuth subsalicylate (BSS) poisoning.
Digestive Health: Finding diarrhea relief. Diarrhea can be unpleasant, but relief is easy to find. Visit your local pharmacy to try a non-prescription diarrhea reliever, such as: bismuth subsalicylate, other products containing attapulgite or loperamide
Pepto Bismol is a medication that treats diarrhea and symptoms associated with indigestion. Its active ingredient, bismuth subsalicylate, can cause your stool to turn black or gray in color. Learn how long it will last and if its normal.
Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.. ...
Medications designed to treat ulcers also lower levels of stomach acid. The most common categories of medications include antacids, proton pump inhibitors, bismuth subsalicylate and H2 receptor...
Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.
Menthol (MEN-thol), Methyl Salicylate (METH-il sa-LIS-i-late) Treats pain. This medicine is a topical analgesic. Brand Name(s): AMPlify Relief MM, Analgesic Balm, Bengay Greaseless, Calypxo, Castiva Cooling, Cool Heat, Golden Sunshine Herbal, Golden Sunshine Natural Herbal Pain Terminator, Good Neighbor Pharmacy Muscle Rub, Good Sense Cool N...
J.A. King; A.B. Sorrow; J.A. Finkelstein (1995). "Urine Trinder spot test: a rapid salicylate screen for the emergency ... The Trinder spot test is a diagnostic test used in medicine to determine exposure to salicylates, particularly to salicylic ... ISBN 1-890883-53-0. Neal Flomenbaum (2006). "Salicylates". In Lewis R. Goldfrank; Neal Flomenbaum; Mary Ann Howland; Robert S. ... M.A. Koupparis; P.I. Anagnostopoulou (1988). "Automated flow injection determination of salicylates using Trinder reaction for ...
Use with other salicylates. Use with NSAIDs. MIMS. "Aloxiprin". MIMS. Retrieved 16 April 2011. Encarta. "Aloxiprin". Encarta. ... People with allergies to salicylates. People with gastrointestinal ulcers. People with liver or kidney damage. Pregnant women ...
Race, Sharla (2012). "Salicylate in Food". The Salicylate Handbook: Your Guide to Understanding Salicylate Sensitivity. Sharla ... Methyl salicylate Trolamine salicylate Salsalate Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names ... Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used ... "Salicylates in foods" (PDF). Retrieved 2014-05-09. Vlot, A. C; Dempsey, D. A; Klessig, D. F (2009). "Salicylic Acid, a ...
175-. ISBN 978-1-4398-0774-3. K. D. Rainsford (22 October 2013). Aspirin and the Salicylates. Elsevier. p. 2. ISBN 978-1-4831- ... A less corrosive compound of salicylic acid, acetylsalicylic acid, produced by reacting sodium salicylate with acetyl chloride ...
Salicylates, potential for severe toxicity. Sodium bicarbonate, potential for kidney stone formation. Anticoagulants, cardiac ...
Salicylates are useful for pain. Steroids are reserved for cases where there is evidence of an involvement of the heart. The ... One should watch for side effects like gastritis and salicylate poisoning. In children and teenagers, the use of aspirin and ...
ISBN 978-1-133-10879-5. "California Poison Control System: Salicylates". Gong DW, He Y, Karas M, Reitman M (1997). "Uncoupling ...
Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate. Aspirin ... Done, AK (November 1960). "Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ... Plasma salicylate levels in general range from 30-100 mg/l after usual therapeutic doses, 50-300 mg/l in people taking high ... Large doses of salicylate, a metabolite of aspirin, cause temporary tinnitus (ringing in the ears) based on experiments in rats ...
Methyl salicylate. Liquid preparations containing more than 5% by weight of methyl salicylate, other than those packaged in ...
Its activity is inhibited by salicylates, which appear to mimic the enzyme's nucleotide substrate. Macromolecular crowding has ... Larsson-Raźnikiewicz, Märtha; Wiksell, Eva (1 March 1978). "Inhibition of phosphoglycerate kinase by salicylates". Biochimica ...
Salicylate sensitivity Salicylates can trigger asthma in sensitive individuals. Salicylates occur naturally in many healthy ... Aspirin is also a salicylate. Use of fossil fuel related allergenic air pollution, such as ozone, smog, summer smog, nitrogen ...
Salicylate sensitivity is a common adverse reaction to the methyl salicylate in oil of wintergreen; it can produce allergy-like ... Methyl salicylate is not present in the plant until formed by enzymatic action from a glycoside within the leaves as they are ... Artificial wintergreen oil, which is pure methyl salicylate, is used in microscopy because of its high refractive index. The ... Spiraea plants also contain methyl salicylate in large amounts and are used similarly to wintergreen. Wintergreen has a strong ...
Salicylates Another frequently used mnemonic is KARMEL. K - Ketoacidosis A - aspirin R - Renal failure M - Methanol E - ... Salicylates A - Alcoholic ketoacidosis L - Lactic acidosis E - Ethylene Glycol The mnemonic for the [rare, in comparison] ...
... there are codeine-based barbiturates and salicylates. http://deadiversion.usdoj.gov/quotas/conv_factor/index.html ...
Non-steroidal anti-inflammatory analgesics other than salicylates. Drugs. 1986;32 Suppl 4:27-45. Review. PMID 3552584 Monthly ...
It is postulated that salicylate [taken by school-age children], operating in a dose-dependent manner, possibly potentiated by ... Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF (6 Dec 1980). "Reye's Syndrome and Salicylate Use". Pediatrics. 66 (6 ... "Surgeon General's advisory on the use of salicylates and Reye syndrome". MMWR. Morbidity and Mortality Weekly Report. 31 (22): ... Reye's Syndrome at NINDS "Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for ...
Levy, G; Tsuchiya, T (1972-09-31). "Salicylate accumulation kinetics in man". New England Journal of Medicine. 287 (9): 430-2. ...
Other medications containing salicylates are often similarly labeled as a precaution. The Centers for Disease Control and ... About 90% of cases in children are associated with aspirin (salicylate) use. Inborn errors of metabolism are also a risk factor ... "New advice on oral salicylate gels in under 16s" (Press release). Medicines and Healthcare products Regulatory Agency. April 23 ... Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF (December 1980). "Reye's syndrome and salicylate use". Pediatrics. 66 ...
Active ingredients: Methyl Salicylate, 1.75% Menthol 3.2%, Camphor 3.0% Salonpas Gel - Menthol and Methyl Salicylate gel-OTC ... Methyl Salicylate passes through the skin and goes directly to the site of your pain, right where it hurts. Therefore, SALONPAS ... Active ingredients: Methyl Salicylate 15%, Menthol 7% Salongsip Aqua-Patch - Menthol jelly patch-Jelly type OTC pain relief ... Active ingredients: Methyl Salicylate 10%, Menthol 3% Salonpas Arthritis Pain - FDA approved OTC pain relief patch. Active ...
... leaving the product salicylate. Salicylate is an aromatic compound found in species from both the plant and bacterial kingdoms ... Salicylate can also be found in various species of plants, where it is used for flowering and resistance against pathogen ... More specifically, IPL will use isochorismate as a substrate and convert it into salicylate and pyruvate. IPL is a PchB enzyme ... Its functions vary depending on the species, but generally salicylate can be used in many bacteria as a building block for ...
The Effect of Salicylates on Experimental Arthritis in Rabbits. Chicago: American Medical Association, 1917. Fantus, Bernard. ... A research program to strengthen New Jersey's competitive position for business and industry The effect of salicylates on ...
... increases the neurotoxicity of high doses of salicylates. (Classified as minor.) Toxicity of cardiac glycosides is ...
nov., a new member of the family Alcaligenaceae that degrades substituted salicylates". Int J Syst Evol Microbiol. 55: 1077-81 ... P. noertemannii has the ability to degrade substituted salicylates. LSPN bacterio.net Straininfo of Pusillimonas noertemannii ...
... salicylates, and nerolidol. The diploid chromosome number of B. nodosa has been determined to be 2n = 40 Kew World Checklist of ...
1945). "Salicylate poisoning - report of 4 cases". American Journal of Diseases of Children. 69: 37-43. doi:10.1001/archpedi. ...
Side effects include skin irritation, and salicylate poisoning. Salicylate poisoning tends to only occur when applied to a ... Side effects include skin irritation, and salicylate poisoning. Salicylate poisoning tends to only occur when applied to a ... Salicylate Toxicity at eMedicine Madan RK; Levitt J (April 2014). "A review of toxicity from topical salicylic acid ...
Control of salicylate intolerance with fish oils. Br J Dermatol. 2008 Dec;159(6):1368-9. PMID 18795922 Charles A. Lewis, ... Some people have reported relief of symptoms by following a low-salicylate diet such as the Feingold diet. Aspirin is quickly ... Salicylate sensitivity Drug intolerance Alcohol-induced respiratory reactions Allergy. 2013 Oct;68(10):1219-32. doi: 10.1111/ ... reported a multi-center prospective randomized cross-over trial with 30 patients following a low-salicylate diet for 6 weeks. ...
At high doses, quinine, aspirin and other salicylates may also cause high-pitch tinnitus and hearing loss in both ears, ... Cazals, Y. (2000-12-01). "Auditory sensori-neural alterations induced by salicylate". Progress in Neurobiology. 62 (6): 583-631 ...
... salicylates for headache rheumatism and fever, nitroglycerin for cardiac angina pectoris;, and bismuth salicylate for diarrhea ...
... began construction of a calcium salicylate plant on Jurong Island in Singapore. Calcium salicylate is used as a ... "UK's Infineum starts building salicylate project in Singapore". Retrieved 2017-12-10. "United States : Infineum Selects ...
... it is proposed to read-across to Cyclohexyl Salicylate, Ethylhexyl salicylate and Methyl salicylate (Source Substances). ... To address toxicological endpoints as part of the REACH registration of Benzyl Salicylate (Target Substance) ...
... or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by ... Salicylates. Subscribe to New Research on Salicylates The salts, esters of salicylic acids, or salicylate esters of an organic ... 05/01/1994 - "[Salicylates in the treatment of Crohn disease].". 01/01/1992 - "Amino-salicylates are effective in ulcerative ... 04/01/1995 - "New salicylates as maintenance treatment in ulcerative colitis.". 09/01/1994 - "New salicylates as maintenance ...
IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains,... ... IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains, soreness and ...
Contact to Methyl Salicylate Exporters in India, Methyl Salicylate Wholesalers, Methyl Salicylate Distributors and Traders from ... Search Indian Methyl Salicylate Manufacturers and Suppliers Details - ... Deals in Sodium Salicylate, Flocculants, Octyl Salicylate, Homo Salicylate, Homo Salicylates, Coagulant Chemicals, salicylic ... Deals in Benzyl Butyrate, Amyl Salicylate, Amyl Phenyl Acetate, amyl alcohol, Benzyl Formate, isobutyl salicylate, Resinoids, ...
Meaning of salicylate. What does salicylate mean? Information and translations of salicylate in the most comprehensive ... Definition of salicylate in the Definitions.net dictionary. ... Search for salicylate on Amazon. *Search for salicylate on ... What does salicylate mean?. Definitions for salicylatesəˈlɪs əˌleɪt, -lɪt, ˌsæl əˈsɪl eɪt, ˈsæl əˌsɪl-. Here are all the ... Get even more translations for salicylate ». Translation. Find a translation for the salicylate definition in other languages: ...
Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to ... Salicylate is also able to stimulate brown adipose tissue respiration independent of UCP1. These data indicate that the primary ... Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK β1 ... Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic ...
... may also be used for purposes not listed in this medication guide. ... Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, ... What is methyl salicylate topical?. Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint ... When using methyl salicylate topical cream, gel, lotion, oil, ointment, or spray: apply a thin layer to the affected area and ...
Copper salicylate is a compound with formula Cu2(C6H5OCOO)2. It is the copper salt of salicylic acid. It is insoluble in water ... It is formed by mixing solutions of copper sulfate and sodium salicylate. It is a light green solid.. ...
Potassium salicylate is the potassium salt of salicylic acid. http://www.chemicalbook.com/ChemicalProductProperty_EN_CB4157001. ...
Methyl salicylate. References[edit]. *^ From DailyMed (a publication of the National Institutes of Health) [1], retrieved 23 ... Trolamine salicylate (Aspercreme, Aspergel) is an organic compound which is the salt formed between triethanolamine and ... "Effect of a Topical 10% Trolamine Salicylate Cream on Delayed Onset Muscular Soreness", Medicine and Science in Sports and ... The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to ...
Effect of salicylates in urticaria.. Br Med J 1967; 4 doi: https://doi.org/10.1136/bmj.4.5574.262 (Published 04 November 1967) ...
Treatments and Tools for salicylate. Find salicylate information, treatments for salicylate and salicylate symptoms. ... salicylate - MedHelps salicylate Center for Information, Symptoms, Resources, ... It has long been held that coumadin should not be taken with any form of salicylate. Howev... ... I have celiac disease, a salicylate intolerance AND milk allergy. My blood test show... ...
If youre allergic to chemicals called salicylates, you may need to avoid certain foods, medicines, and products. WebMD ... Foods That Contain Salicylates Products That May Contain Salicylates Salicylate-Containing Ingredients ... Magnesium salicylate. Menthol. Mint. Salicylic acid. Peppermint. Phenylethyl salicylate. Sodium salicylate. Spearmint. ... What Is a Salicylate Allergy?. Articles OnDrug Allergies. Drug Allergies Drug Allergies - What Is a Salicylate Allergy? * Drug ...
Surgeon Generals Advisory on the Use of Salicylates and Reye Syndrome Because the use of salicylates such as aspirin for ... advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox.* ... the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. ... The association of salicylates with Reye syndrome is based upon evidence from epidemiologic studies that are sufficiently ...
Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. It is used in many over-the-counter products ... Methyl salicylate is the most poisonous form of the salicylate type of chemicals. ... Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. It is used in many over-the-counter products ... Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. This can be ...
... making salicylate toxicity an important cause of morbidity and mortality. (See Epidemiology. ... Salicylates are ubiquitous agents found in hundreds of over-the-counter (OTC) medications and in numerous prescription drugs, ... encoded search term (Salicylate%20Toxicity) and Salicylate Toxicity What to Read Next on Medscape. Related Conditions and ... Delayed Salicylate Toxicity in a 17-Year-Old Girl With Initially Undetectable Salicylate Concentration 3.9 Hours After ...
... Mark Strom strom at stein.u.washington.edu Fri Mar 5 13:22:50 EST 1993 *Previous message: salicylate ... the use of sodium salicylate as a fluor for H3, S35, ,and C14 labelled protein acrylamide gels. Ive used 0.5 M salicylate-1.5 ...
Other names: Benzoic acid, 2-hydroxy-, methyl ester; Salicylic acid, methyl ester; O-Hydroxybenzoic acid, methyl ester; Analgit; Betula; Betula oil; Betula Lenta; Exagien; Flucarmit; Gaultheria oil; Gaultheria oil, artificial; Gaultheriaoel; Methyl o-hydroxybenzoate; Methyl 2-hydroxybenzoate; Oil of Wintergreen; Spicewood oil; Sweet birch oil; Teaberry oil; Wintergreen oil; Wintergruenoel; 2-(Methoxycarbonyl)phenol; 2-Hydroxybenzoic acid, methyl ester; Natural wintergreen oil; Synthetic wintergreen oil; Wintergreen oil, synthetic; Methyl ester of 2-hydroxy-benzoic acid; 2-Carbomethoxyphenol; NSC 8204; Salonpas; Theragesic; 8022-86-4; 648434-07-5; 8024-54-2; 2-Hydroxy methyl ester benzoic acid; Methyl ester 2-hydroxy-benzoic acid ...
About BENZYL SALICYLATE: Benzyl Salicylate is an ester of benzyl alcohol and salicylic acid; this ingredient has been ... Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer ...
About SILANEDIOL SALICYLATE: Silanediol Salicylate is a product obtained by the hydrolysis of dimethylsilylsalicylate.. ...
Definition of magnesium salicylate. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... magnesium salicylate. Definition: a sodium-free salicylate derivative with antiinflammatory, analgesic, and antipyretic actions ...
Aspirin Prostaglandin Salicylic Acid Salicylate Rapid Action This is a preview of subscription content, log in to check access ... J.A. Sturman andM.J.H. Smith,The Binding of Salicylate to Plasma Proteins in Different Species, J. Pharm. Pharmac.19, 621-623 ( ... M.J.H. Smith andP.D. Dawkins,Salicylate and Enzymes, J. Pharm. Pharmac.23, 729-744 (1971).Google Scholar ... E. Quilley andM.J.H. Smith,The Application of Paper Partition Chromatography to the Study of the Metabolism of Salicylate in ...
Salicylates answers are found in the Washington Manual of Medical Therapeutics powered by Unbound Medicine. Available for ... Salicylates. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters ... Salicylates is a topic covered in the Washington Manual of Medical Therapeutics. To view the entire topic, please sign in or ... Salicylate toxicity may result from acute or chronic ingestion of acetylsalicylic acid (aspirin is a generic name in the United ...
Acute Renal Failure in Salicylate Poisoning Br Med J 1958; 1 :503 ... Acute Renal Failure in Salicylate Poisoning. Br Med J 1958; 1 doi: https://doi.org/10.1136/bmj.1.5069.503 (Published 01 March ...
Salicylates are a type of drug found in aspirin and other medicines. Salicylates are usually safe for adults when taken at the ... This test measures the amount of salicylates in blood. ... Salicylates are a type of drug found in many over-the-counter ... What is a salicylates level test?. This test measures the amount of salicylates in the blood. ... A salicylates level test is most often used to:. *Help diagnose acute or gradual aspirin poisoning. Acute aspirin poisoning ...
The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies ... encoded search term (What is the role of salicylates in the etiology of Reye syndrome?) and What is the role of salicylates in ... component of the enzyme as the target of salicylate inhibition. [3] Absence of inhibition of beta-oxidation by salicylates in ... 1] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and ...
The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies ... component of the enzyme as the target of salicylate inhibition. [3] Absence of inhibition of beta-oxidation by salicylates in ... 1] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and ... A causal relation between Reye syndrome and salicylates has not been definitively established and has been questioned on the ...
Amyl salicylate definition is - the salicylic ester C6H4(OH)COOC5H11 of commercial amyl alcohol that is a liquid of lasting ... pleasant odor used chiefly as an ingredient of perfumes and soaps -called also isoamyl salicylate. ... Share amyl salicylate Post the Definition of amyl salicylate to Facebook Share the Definition of amyl salicylate on Twitter ... Dictionary Entries near amyl salicylate. amyloplast amylopsin amylose amyl salicylate amylum body amylum center amylum grain ...
... patients took more salicylate-containing medications than did control children (P , .01). All seven patients took salicylate ... salicylate consumption was correlated with severity of Reyes syndrome (P , .05). It is postulated that salicylate, operating ... Reyes Syndrome and Salicylate Use. Karen M. Starko, C. George Ray, Lee B. Dominguez, Warren L. Stromberg and Dora F. Woodall ... Reyes Syndrome and Salicylate Use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National Patterns of ...
Easy to read patient leaflet for acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine. Includes indications, proper use ... Acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine has a salicylate in it, which has been linked to a serious illness ... Acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine has a salicylate in it. Before you start any new medicine, check ... Acetaminophen/ caffeine/ magnesium salicylate/ phenyltoloxamine. Generic Name: acetaminophen/caffeine/magnesium salicylate/ ...
... SCHEDULING STATUS:. PROPRIETARY NAME. (and dosage form):. SODIUM SALICYLATE MIXTURE BPC ... Salicylates alleviate pain by virtue of both a peripheral and a C.N.S. effect. Salicylates, by inhibiting the synthesis of ... Sodium Salicylate has analgesic, anti-inflammatory and antipyretic action. The types of pain amenable to relief by salicylates ... Sodium Salicylate BP: 0,5 g. PHARMACOLOGICAL CLASSIFICATION:. 2.8 Non narcotic analgesics, antipyretics.. PHARMACOLOGICAL ...
Methyl salicylate ≥99%; CAS Number: 119-36-8; EC Number: 204-317-7; Synonym: 2-Hydroxybenzoic acid methyl ester, Methyl 2- ... Methyl salicylate ≥99% Synonym: 2-Hydroxybenzoic acid methyl ester, Methyl 2-hydroxybenzoate, Oil of wintergreen, Wintergreen ...
Magnesium salicylate is used to treat mild-to-moderate pain, fever, inflammatory conditions, and pain, swelling, or stiffness ... Magnesium salicylate is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and ... What is magnesium salicylate?. Magnesium salicylate is a salicylate (sa-LIS-il-ate). It works by reducing substances in the ... Magnesium salicylate can cause Reyes syndrome, a serious and sometimes fatal condition in children. Magnesium salicylate is ...
Salicylate sensitivity is associated with a variety of symptoms, making it hard to identify. This article explains its causes, ... Should You Avoid Salicylates?. There is no reason to avoid salicylates unless you suspect that you have an intolerance to them ... While salicylate sensitivity, also known as salicylate intolerance, is not as common as gluten or lactose intolerance, its a ... What Causes Salicylate Sensitivity?. While consuming excessive amounts of salicylates can result in adverse reactions in anyone ...
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... when a salicylate test is requested, and what the results of a salicylate test might mean ... Salicylate result (mg/L). Salicylate result (mmol/L). Result Interpretation. 20-100. 0.1-0.7. Therapeutic level for pain relief ... A salicylate test may be used to monitor for an overdose if an individual regularly takes high doses of salicylate, such as to ... This test is used to detect a high level of salicylate in the blood. It may be used to help diagnose an overdose (salicylate ...
  • Clinical presentations of patients with salicylate toxicity range from minor symptoms to a syndrome initially indistinguishable from septic shock. (unboundmedicine.com)
  • The very young and elderly are prone to develop severe toxicity, as are those with chronic salicylate intoxications. (unboundmedicine.com)
  • For chronic salicylate toxicity, recognition of the symptoms, withdrawal of the drug, and supportive measures are indicated. (kidneytreatment.site)
  • Likewise, salicylate protected kidney function (measured as plasma blood urea nitrogen and creatinine levels) from CDDP toxicity. (elsevier.com)
  • Nausea, vomiting, diaphoresis, and tinnitus are the earliest signs and symptoms of salicylate toxicity. (amfs.com)
  • Patients with chronic rather than acute ingestions of salicylates are more likely to develop toxicity, especially of the CNS, and require intensive care. (amfs.com)
  • Methyl salicylate ointment is a common dermatology drug with analgesic, anti-inflammatory, bactericidal effect. (lookchem.com)
  • Methyl salicylate is used in high concentrations as a rubefacient and analgesic in deep heating liniments (such as Bengay) to treat joint and muscular pain. (laballey.com)
  • There was no way to test for salicylates, and, every allergy test, just showed I was slightly allergic to tomatoes. (newrinkles.com)
  • You should not use if your pet is allergic to aspirin or other salicylates. (petplace.com)
  • Use only if your formulation does NOT contain salicylates. (petplace.com)
  • Salsalate is part of a class of naturally occurring chemicals known as salicylates, which are among the oldest prescribed medicinal anti-inflammatories [1]. (sonomechanics.com)
  • OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). (gwu.edu)
  • Conditions causing concurrent acidosis may increase tissue salicylate concentrations resulting in greater morbidity and mortality. (unboundmedicine.com)
  • Methyl salicylate is used in low concentrations (0.04% and under)[14] as a flavoring agent in chewing gum and mints. (laballey.com)
  • Minimum concentrations of 10 xg/L (aspirin) and 0.5 mg/L (salicylate) can be measured using 1 ml of plasma. (edu.au)
  • Although determination of serial serum salicylate concentrations offers valuable information regarding the effectiveness of the treatment implemented, assessment of these levels is a poor substitute for clinical evaluation of a patient. (amfs.com)
  • The results suggest that administration of salicylate may become the basis of an effective therapeutic intervention against the ototoxic and nephrotoxic side effects associated with CDDP chemotherapy. (elsevier.com)
  • The therapeutic range of salicylates is 15-30 mg/dl. (amfs.com)
  • The most common salicylate is acetylsalicylic acid (ASA) (coined Aspirin by Bayer in 1899) and its main biochemical function is the reduction of inflammation and fever via the inhibition of cyclooxygenase enzymes (COX) [2]. (sonomechanics.com)
  • The mainstay for treatment of salicylate intoxication remains alkalinisation of blood and urine. (kidneytreatment.site)
  • The treatment of salicylate poisoning by forced alkaline diuresis is now well established, but the position of. (kidneytreatment.site)
  • Pepto-Bismol® should not be used in cats since it contains salicylates, the active ingredient in aspirin. (petplace.com)
  • Many of these medicines may contain salicylate. (amfs.com)
  • These actions cause sequential and progressively severe physiologic abnormalities based on increasing doses of salicylates, time following exposure, duration of chronic exposure, extremes of age, and presence of comorbid conditions. (unboundmedicine.com)
  • Because salicylate-like compounds are slowly eliminated in cats, one should be careful not to exceed the recommended doses for cats. (petplace.com)
  • Salicylates are neurotoxic, which is manifested as tinnitus, and ingestion can lead to hearing loss at doses of 20-45 mg/dL or higher. (amfs.com)
  • IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains, soreness and stiffness of muscles. (medshopexpress.com)
  • Salicylate sensitivity or intolerance symptoms are extremely varied. (newrinkles.com)
  • however, the following symptoms often appear when a person has salicylate sensitivity or salicylate intolerance. (newrinkles.com)
  • For instance, a person who is exposed day after day to salicylates could develop one of the symptoms mentioned above and then other problems could result. (newrinkles.com)
  • If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. (newrinkles.com)
  • What that means is that your body can handle a certain amount of salicylates, but at some point it becomes toxic. (newrinkles.com)
  • Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. (kidneytreatment.site)
  • Similarities in the toxic mechanisms suggest salicylate as a treatment strategy to prevent the ototoxic side effects of cisplatin (CDDP). (elsevier.com)
  • The clinician must determine the type of salicylate preparation, the amount, the time of ingestion, the degree of chonicity of ingestion, and the patient's existing medical conditions. (amfs.com)
  • Methyl salicylate is an organic compound with the formula C₆H₄. (laballey.com)
  • Salicylate poisoning is manifested clinically by disturbances of several organ systems, including the CNS and the cardiovascular, pulmonary, hepatic, renal, and metabolic systems. (amfs.com)
  • After collection, plasma is first treated with physostigmine sulfate to inhibit enzymatic hydrolysis of aspirin to salicylate. (edu.au)
  • however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. (newrinkles.com)
  • In patients with severe salicylate intoxication and in patients presenting with. (kidneytreatment.site)
  • The assay has been used for the study of simultaneous aspirin and salicylate pharmacokinetics after a single oral dose of 100 mg soluble glycinated aspirin for platelet antiaggregatory therapy in six subjects, one of whom was also studied after receiving a 600 mg dose. (edu.au)
  • Salicylate-poisoned patients can be incredibly complex and severely ill. (kidneytreatment.site)
  • Salicylate poisoning may cause noncardiogenic pulmonary edema (NCPE) in a few patients. (amfs.com)
  • Salicylates are ubiquitous agents found in hundreds of over-the-counter (OTC) medications and in numerous prescription drugs including topical preparations used for the treatment of pain, warts, and acne. (amfs.com)
  • What is the most important information I should know about methyl salicylate topical? (johnstonhealth.org)
  • Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. (johnstonhealth.org)
  • Methyl salicylate topical may also be used for purposes not listed in this medication guide. (johnstonhealth.org)
  • What should I discuss with my healthcare provider before using methyl salicylate topical? (johnstonhealth.org)
  • Ask a doctor or pharmacist about using methyl salicylate topical if you have any allergies (especially to aspirin or other salicylates), or if you have a serious medical condition. (johnstonhealth.org)
  • It is not known whether methyl salicylate topical will harm an unborn baby. (johnstonhealth.org)
  • It is not known whether methyl salicylate topical passes into breast milk or if it could harm a nursing baby. (johnstonhealth.org)
  • Do not apply methyl salicylate topical to your breast area if you are breast-feeding a baby. (johnstonhealth.org)
  • How should I use methyl salicylate topical? (johnstonhealth.org)
  • Make sure your skin is clean and dry before you apply methyl salicylate topical. (johnstonhealth.org)
  • To apply a methyl salicylate topical skin patch , remove the liner and apply the patch to your skin over the area of pain. (johnstonhealth.org)
  • Methyl salicylate topical may be used up to 4 times daily or as directed on the medicine label. (johnstonhealth.org)
  • Wash your hands with soap and water immediately after applying methyl salicylate topical or handling the skin patch. (johnstonhealth.org)
  • Salicylates also interfere with the Krebs cycle, limit production of ATP, and increase lactate production, leading to ketosis and a wide anion-gap metabolic acidosis. (amfs.com)
  • Aspirin, or more specifically salicylates, are also a cause of anion gap metabolic acidosis in overdose. (nephsim.com)
  • Do not use if your formulations lists salicylates as an active ingredient. (petplace.com)
  • The active ingredient in Pepto-Bismol and the new formulation of Kaopectate is salicylate. (petplace.com)
  • Optimal management of a salicylate poisoning depends on whether the exposure is acute or chronic. (amfs.com)
  • Salicylates directly or indirectly affect most organ systems in the body by uncoupling oxidative phosphorylation, inhibiting Krebs cycle enzymes, and inhibiting amino acid synthesis. (amfs.com)
  • Salicylates cause both direct and indirect stimulation of respiration. (amfs.com)
  • Salicylates stimulate the respiratory center, leading to hyperventilation and respiratory alkalosis. (amfs.com)