The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
Salts and esters of gentisic acid.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC and EC
A plant genus of the family ERICACEAE. The common name of "wintergreen" is also used for PYROLA and "snowberry" is also used for SYMPHORICARPOS.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.
Places for cultivation and harvesting of fish, particularly in sea waters. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.
A plant genus of the family CORNACEAE. It is widely cultivated for the attractive flowers.
A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.

Perinatal nephropathies. (1/1030)

The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation.  (+info)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)

Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate.  (+info)

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.  (+info)

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.  (+info)

NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)

Two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10. While nahG resides in the same transcriptional unit as the meta-cleavage pathway genes, forming the naphthalene degradation lower pathway, nahW is situated outside but in close proximity to this transcriptional unit. The nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism. Both genes, nahG and nahW, have been cloned in Escherichia coli JM109. The overexpression of these genes yields peptides with apparent molecular masses of 46 kDa (NahG) and 43 kDa (NahW), respectively. Both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates, and chlorosalicylates. However, the relative rates by which the substituted analogs are transformed differ considerably.  (+info)

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)

1. The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the activation of NF-kappaB elicited by tumour necrosis factor-alpha (TNF-alpha) on human umbilical vein endothelial cells (HUVEC) was tested. 2. The expression of the mRNA of vascular cell adhesion molecule-1 (VCAM-1) was studied as an example of a gene the expression of which is regulated by NF-kappaB. To extend these findings to other systems, the induction of nitric oxide synthase in rat adherent peritoneal macrophages was studied. 3. Both HTB and triflusal were more potent than aspirin or salicylate as inhibitors of the nuclear translocation of NF-kappaB. The calculation of the IC50 values showed approximately 2 mM for HTB, 4 mM for aspirin and >4 mM for salicylate. 4. Comparison of the potency of these compounds on VCAM-1 mRNA expression showed complete inhibition by both triflusal and HTB at a concentration of 4 mM whereas aspirin and salicylate produced only 36-43% inhibition at the same concentration. 5. Inhibition of NF-kappaB activation was also observed in rat peritoneal macrophages stimulated via their receptors for the Fc portion of the antibody molecule with IgG/ovalbumin immune complexes. This was accompanied by a dose-dependent inhibition of nitrite production by the L-arginine pathway via iNOS. IC50 values for this effect were 1.13+/-0.12 mM (triflusal), 1.84+/-0.34 (HTB), 6.08+/-1.53 mM (aspirin) and 9.16+/-1.9 mM (salicylate). 6. These data indicate that the incorporation of a 4-trifluoromethyl group to the salicylate molecule strongly enhances its inhibitory effect on NF-kappaB activation, VCAM-1 mRNA expression and iNOS induction, irrespective of the presence of the acetyl moiety involved in the inhibition of cyclo-oxygenase.  (+info)

Reye's syndrome in the United States from 1981 through 1997. (7/1030)

BACKGROUND: Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella. Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome. METHODS: To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and risk factors for poor outcomes, we analyzed national surveillance data collected from December 1980 through November 1997. The surveillance system is based on voluntary reporting with the use of a standard case-report form. RESULTS: From December 1980 through November 1997 (surveillance years 1981 through 1997), 1207 cases of Reye's syndrome were reported in patients less than 18 years of age. Among those for whom data on race and sex were available, 93 percent were white and 52 percent were girls. The number of reported cases of Reye's syndrome declined sharply after the association of Reye's syndrome with aspirin was reported. After a peak of 555 cases in children reported in 1980, there have been no more than 36 cases per year since 1987. Antecedent illnesses were reported in 93 percent of the children, and detectable blood salicylate levels in 82 percent. The overall case fatality rate was 31 percent. The case fatality rate was highest in children under five years of age (relative risk, 1.8; 95 percent confidence interval, 1.5 to 2.1) and in those with a serum ammonia level above 45 microg per deciliter (26 micromol per liter) (relative risk, 3.4; 95 percent confidence interval, 1.9 to 6.2). CONCLUSIONS: Since 1980, when the association between Reye's syndrome and the use of aspirin during varicella or influenza-like illness was first reported, there has been a sharp decline in the number of infants and children reported to have Reye's syndrome. Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome.  (+info)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)

OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels.  (+info)

Bismuth subsalicylate, sold under the brand name Pepto-Bismol, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea. It is also commonly known as pink bismuth. Bismuth subsalicylate has the empirical chemical formula of C7H5BiO4, and it is a colloidal substance obtained by hydrolysis of bismuth salicylate (Bi(C6H4(OH)CO2)3). The actual structure[clarification needed] is unknown and the formulation is only approximate. As a derivative of salicylic acid, bismuth subsalicylate displays anti-inflammatory and bactericidal action. It also acts as an antacid. There are some adverse effects. It can cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in saliva and the colon to form bismuth sulfide. Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless. Long-term use (greater than 6 weeks) may lead ...
2-Trifluoromethylbenzoic acid, 3,5-difluorophenyl ester | C14H7F5O2 | CID 530822 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
If you are allergic to any ingredients in bismuth subsalicylate or if you are allergic to salicylate pain relievers, you should not take this medicati
An original, highly sensitive and specific high performance liquid chromatographic method has been developed for the measurement of aspirin and salicylate in plasma. Minimum concentrations of 10 xg/L (aspirin) and 0.5 mg/L (salicylate) can be measured using 1 ml of plasma. After collection, plasma is first treated with physostigmine sulfate to inhibit enzymatic hydrolysis of aspirin to salicylate. Maximal recovery is achieved using an acid extraction into anhydrous diethyl ether with a subsequent drying-down step in an iced water bath. Aspirin and salicylate are separated by elution with a mixture of methanol, 1-butanol, orthophosphoric acid, and water on a reversed-phase octadecyl silane column at 47°C and detected at 234 nm by ultraviolet absorption. Quantitation is achieved using the peak height ratio of aspirin and salicylate to internal standard (m-anisic acid). The assay has been used for the study of simultaneous aspirin and salicylate pharmacokinetics after a single oral dose of 100 mg ...
Anyone can be, or become, sensitive to anything, including salicylates. It happens when people or over exposed or continually exposed; however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. It also tends to affect older adults or people who have worsening asthma problems, and, yet, the worsening asthma problems may be related to continual exposure to salicylates. So, its a vicious cycle as your health continues to deteriorate, and you experience more and more health problems.. If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. For more information on salicylates in food or how to conduct a test see the How Do I Get More Information?section at the bottom of this article. If you have salicylate problems and remove them from your life, your ...
Use only if your formulation does NOT contain salicylates. Pepto-Bismol® should not be used in cats since it contains salicylates, the active ingredient in aspirin. Cats are very sensitive to aspirin so it should be avoided. WARNING - PLEASE NOTE THAT THE NEW FORMULATIONS OF KAOPECTATE MAY ALSO HAVE SALICYLATES. Do not use if your formulations lists salicylates as an active ingredient. Any vomiting or diarrhea that persists for more than 24 hours needs your veterinarian's attention. ...
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Toxicokinetics The 17 salicylate substances assessed in the RIFM review indicate consistent metabolism by hydrolysis to form salicylic acid and the alcohol of the corresponding side chain. This pattern of metabolism is consistent with information on other esters which are hydrolysedin vivoby carboxylesterases or esterases, especially the A-esterases. In vivo metabolic data are available for methyl salicylate and one human metabolism study is available on phenyl salicylate. Carboxylesterases show extensive tissue distribution with respect to hydrolysis of methyl salicylate. In vitro studies demonstrate greatest activity in the liver, but also extensive activity in the intestines, kidney, pancreas and spleen. Both the liver and intestines can contribute to the pre-systemic hydrolysis of salicylates. Oral consumption of 0.42 mL methyl salicylate by human volunteers resulted in the rapid appearance of salicylic acid in the plasma. At 15 and 90 minutes post administration, salicylic acid ...
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM). Salsalate treatment increased oxygen consumption, lowered fasting glucose, improved glucose tolerance and led to an ∼55% reduction in liver lipid content; effects observed in both WT and AMPK β1KO mice. To explain these AMPK-independent effects, it was found that salicylate increases oligomycin-insensitive respiration (state 4o) and directly increases mitochondrial proton conductance at clinical concentrations. This ...
It is important to note that cats are more sensitive to toxicity with salicylates and should never be given this medication.. Signs and symptoms of toxicity: vomiting, diarrhea, melena (dark, tarry stool), abdominal pain, pale gums, altered mental status, difficulty breathing, and dehydration. While some signs may appear within several hours of ingestion, it may take several days for other signs to appear.. Toxic consumption: Do not exceed dosing recommendations from your veterinarian. Report all incidents of accidental ingestion immediately.. References ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The salicylate assay aids in the diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to insure appropriate therapy. Salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic acid (aspirin) is the most commonly used salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. For this reason, salicylates are often seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Prompt recognition and management are necessary to avoid serious consequences. ...
Bismuth by Jamp Pharma: Bismuth subsalicylate belongs to a class of medications called antacids and adsorbents. It is used to help relieve heartburn, indigestion, upset stomach, nausea, and diarrhea. How bismuth subsalicylate works is not completely understood, but it is thought to work by coating the stomach and intestines (protecting them from stomach acid), by reducing inflammation in the stomach, and by killing certain bacteria.
This data point has been waived for hexyl salicylate on the grounds that exposure is not expected to occur. A study by Simonich et al (2000) demonstrated that hexyl salicylate removal is highly efficient during wastewater treatment (98.7 - 99.8% following primary and secondary removal, depending on the type of treatment), and consequently exposure to soil (i.e. via spreading of sludge) will be negligible. Furthermore, hexyl salicylate is readily biodegradable and therefore non-persistent in the environment. Resulting degradation products show low log Kow values and low anticipated ecotoxicity, and the equilibrium partitioning method is therefore considered sufficiently conservative for risk assessment. Under these circumstances, data for the effects of hexyl salicylate on terrestrial arthropods are considered unnecessary. ...
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Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. Early on these may be subtle while larger doses may result in fever. Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. Excess doses can be either on purpose or accidental. Small amounts of oil of wintergreen can be toxic. Diagnosis is generally based on repeated blood tests measuring aspirin levels and blood gases. While a type of graph has been created to try to assist with diagnosis, its general use is not recommended. In overdose maximum blood levels may not occur for more than 12 hours. Efforts to prevent poisoning include child-resistant packaging and a lower number of pills per package. Treatment may include ...
OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation end products (AGEs) that have been implicated in diabetic vascular complications. RESEARCH DESIGN AND METHODS Participants were from the Targeting Inflammation Using Salsalate for Type 2 Diabetes (TINSAL-T2D) study, which examined the impact of salsalate treatment on hemoglobin A1c (HbA1c) and a wide variety of other parameters. One hundred eighteen participants received salsalate, 3.5 g/day for 48 weeks, and 109 received placebo. Early glycation product levels (HbA1c and fructoselysine [measured as furosine]) and AGE levels (glyoxal and methylglyoxal hydroimidazolones [G-(1)H, MG-(1)H], carboxymethyllysine [CML], carboxyethyllysine [CEL], pentosidine) were measured in patient serum samples. RESULTS Forty-eight weeks of salsalate treatment lowered levels of HbA1c and serum furosine (P
TY - JOUR. T1 - Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. AU - Li, Geming. AU - Sha, Su Hua. AU - Zotova, Elena. AU - Arezzo, Joseph. AU - Van De Water, Thomas R.. AU - Schacht, Jochen. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Salicylate has recently been demonstrated to protect against the auditory and vestibular side effects of aminoglycoside antibiotics. Similarities in the toxic mechanisms suggest salicylate as a treatment strategy to prevent the ototoxic side effects of cisplatin (CDDP). We first tested protection of the inner ear in Wistar rats receiving a single infusion of 16 mg CDDP/kg body weight with or without treatment with 100 mg/kg salicylate (bid) for 5 days beginning one day before the CDDP infusion. Cisplatin induced a threshold shift of more than 30 dB (at 14 kHz; measured by auditory evoked brain stem response) that was significantly reduced by salicylate. We then examined the protective potential of ...
It is concluded that the absorption of 2-ethylhexyl salicylate via the dermal route is very low (3%), while it is well absorbed via the oral route (100% absorption assumed). Following absorption, 2-ethylhexyl salicylate is metabolized to salicylic acid and 2-ethylhexanol rapidly. Salicylic acid is mainly excreted by renal excretion as an unchanged chemical entity or after conjugation with glycine as salicyluric acid. 2-Ethylhexanol is metabolized following metabolic pathways of alcohols with its degradation products mainly excreted in respiratory CO2, via faeces and urine. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (salicylic acid and 2-ethylhexanol) with established elimination routes. Due to low vapor pressure (1.8E-4hPa at 20 °C, Symrise) and high boiling point (, 300 °C, Intertek ASG), the inhalation route is not considered to be a relevant exposure route to human for 2-ethylhexyl salicylate. ...
Salicylates are a group of drugs, including aspirin, that are used to relieve pain and inflammation and to reduce fever. Salicylate testing may be used to detect a high level of salicylate in the blood and help diagnose an overdose (salicylate poisoning).
Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Methyl salicylate topical may also be used for purposes not listed in this medication guide.
Methyl Salicylate containing medications, Methyl Salicylate indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from
The interference of analgesics with ACTs (Coartem, Corsucam…) has barely been studied in clinical trials.. Aspirin (acetylsalicylic acid) is sold over the counter in Africa and appears to be the first line treatment when children or adults have fever. Chronic salicylate poisoning by overdosis is common. Many children brought to a hospital in Africa have a high load of salicylic acid in their blood. Paracetamol is also of common use.. In all children admitted to Kilifi District Hospital between July and September, 1994, who had a positive blood film for Plasmodium falciparum, and one or more of coma, prostration, or respiratory distress salicylate concentrations were measured. (English M1, et al., Lancet. 1996 347(9017):1736-7). Data were available for 143 children with initial primary diagnoses of severe malaria. 129 had detectable (,l mg/dL) salicylate. Six of these had salicylate concentrations of 20 mg/dL or higher. All six had neurological impairment and metabolic acidosis and four were, ...
SALICYLIC ACID 477 Methyl Salicylate. This is also known as artificial oil of wintergreen, and is obtained by the interaction of methyl alcohol and salicylic acid. It is a colourless liquid, having a characteristic, aromatic odour and a sweetish, warm, aromatic taste. It is slightly soluble in water, and freely soluble in alcohol, ether, chloroform, glacial acetic acid or carbon bisulphide. Methyl salicylate is taken accidentally, suicidally or to procure abortion, and causes symptoms of acute gastro-intestinal irritation resembling those of poisoning by salicylic acid, followed occasionally by death. About an ounce of methyl salicylate proved fatal to an adult woman in 15 hours42 and a dose of 50 ml. of methyl salicylate caused the death of a middle aged woman hi about 11 hours.43 Doses of 10 cc. to 12 cc. of methyl salicylate have killed children.44 On the other hand, a child, aged 2 years, recovered after swallowing an ounce.45 The treatment consists in the washing out of the stomach and ...
Choline salicylate + cetalkonium chloride is used in the treatment of .get complete information about choline salicylate + cetalkonium chloride including usage, side effects, drug interaction, expert advice along with medicines associated with choline salicylate + cetalkonium chloride at
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Definition of salicylate in the dictionary. Meaning of salicylate. What does salicylate mean? Information and translations of salicylate in the most comprehensive dictionary definitions resource on the web.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.. Check the label of all over-the-counter (OTC), nonprescription, and prescription medicines you now take. If any of them contain acetaminophen, aspirin, other salicylates such as bismuth subsalicylate (e.g., Pepto Bismol) or magnesium salicylate (e.g., Nuprin Backache Caplets), or salicylic acid (present in some shampoos and skin products), check with your health care professional. Using any of them together with this medicine may cause an overdose.. Do not drink alcoholic beverages while taking this medicine. Stomach problems may be more likely to occur if you drink alcoholic beverages while you are taking aspirin or ibuprofen. Also, liver damage may be more likely to occur if you drink large amounts of alcoholic beverages while you are taking acetaminophen.. If you think that you or anyone else may have taken an overdose of this ...
Good Neighbor Pharmacy Anti-diarrheal Made with protective coating 102 mg Salicylate/tablet 262 mg Bismuth subsalicylate/tablets 30 chewable tablets/box
Summary of evidence. Traveler setting: Prevention of TD is challenging because of the ubiquitous exposures to individuals through contaminated food, water, and generally unhygienic conditions among much of the developing world. Travelers are frequently counseled on preventive risk behaviors, but despite a travelers best attention to such recommendations, evidence is lacking that such precautions have any protective effect (188). Although vaccines for many of the agents commonly associated with TD are under development, these are considered a long-term solution and might likely suffer from the lack of utilization as has been seen with most travel-associated vaccines (202, 203, 204,205, 206). Alternative primary prevention strategies such as BSS, probiotics, and antibiotics have been evaluated and are considered here.. Bismuth subsalicylate. BSS has been shown in several studies to reduce the frequency of TD when used during period of risk for 3 weeks (207, 208, 209). While the salicylate portion ...
At first glance, bismuth doesnt seem to be particularly extraordinary. Element number 83 is probably most likely encountered in the compound bismuth subsalicylate (C7H5BiO4), used in gastro-intestinal remedies such as Pepto Bismol. The pure metal is also gaining popularity as a more environmentally friendly (and much more expensive) alternative to lead in hunting ammunition. In…
Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. Hemodialysis. For chronic salicylate toxicity,
Salsalate is insoluble in acid gastric fluids (,0.1 mg/ml at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body: its half-life is about one hour. About 13% is excreted through the kidneys as a glucuronide conjugate of the parent compound, the remainder as salicylic acid and its metabolites. Thus, the amount of salicylic acid available from salsalate is about 15% less than from aspirin, when the two drugs are administered on a salicylic acid molar equivalent basis (3.6 g salsalate/5 g aspirin ...
Continuous decline in cognitive performance accompanies the natural aging process in humans, and multiple studies in both humans and animal models have indicated that this decrease in cognitive function is associated with an age-related increase in oxidative stress. Treating aging mammals with exogenous free radical scavengers has generally been shown to attenuate age-related cognitive decline and oxidative stress. I assessed the effectiveness of the superoxide dismutase/catalase mimetics EUK-189 and EUK-207 on age-related decline in cognitive function and increase in oxidative stress. C57/BL6 mice received continuous treatment via osmotic minipumps with either EUK-189 or EUK-207 for 6 months starting at 17 months of age. At the end of treatment, markers for oxidative stress were evaluated by analyzing levels of free radicals, lipid peroxidation and oxidized nucleic acids in brain tissue. In addition, cognitive performance was assessed after 3 and 6 months of treatment with fear conditioning. ...
These results indicate that pretreatment of rats with the synthetic catalytic scavenger of ROS, EUK-134, prevents oxidative stress and produces a significant degree of protection against the pathological manifestations of KA-induced seizure activity in hippocampus and piriform cortex. Although numerous studies have suggested that ROS are critically involved in excitotoxicity (see refs. 5, 30, and 31 for reviews), very few studies have demonstrated convincingly, in an in vivo excitotoxic model, a causal relationship between increased production of ROS and neuronal damage (7, 32). A clear demonstration of the crucial role of ROS in excitotoxicity should include: (i) evidence for increased production of ROS specifically in neuronal populations at risk with excitotoxicity before overt signs of neuronal damage and (ii) evidence that manipulations aimed at preventing ROS accumulation reduce neuronal damage without interfering with excitatory amino acid receptor functions. The former has been difficult ...
Buy High Purity Methyl Salicylate | Medical Grade For Sale Online In USA | Oil of Wintergreen | For Topical Pain Relief Ointments | 100ml $16.00 | Methyl Ester Of Salicylic Acid | Formula C8H8O3 | Synthetic Form | CAS 119-36-8 | Weight 152.15 | Bulk Supplier & Distributor
Triflusal Triflusal Systematic (IUPAC) name 2-acetyloxy-4-(trifluoromethyl)benzoic acid Identifiers CAS number  ? ATC code B01AC18 PubChem 9458 Chemical
After an excitotoxic lesion in the postnatal cortex, glial NF-κB is consistently activated at 10 hours after injury, showing its peak at day 1.4 Therefore, when triflusal is orally administered 8 hours after the NMDA injection, it preferentially targets NF-κB induced in glial cells, as the inducible neuronal NF-κB is starting to decrease when triflusal reaches the brain. Glial NF-κB is probably induced by injury-related signals that occur in the degenerating area. They may include reactive oxygen species, produced in excitotoxically damaged cells,44 and the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α, which are expressed by neurons and glial cells in this excitotoxic lesion model, showing a peak of expression at 10 hours after injury.45 On activation, NF-κB translocates to the cell nucleus and modulates the expression of several genes implicated in the development of the glial and inflammatory responses. Target genes containing a NF-κB-binding site include the ...
Temporarily relieves minor aches and pains. IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains,...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis. We will evaluate the effects of targeting inflammation using the anti-inflammatory drug salsalate, compared to placebo, on coronary artery plaque volume assessed by multi-detector computed tomographic angiography (MDCTA). The TINSAL-CVD study is a randomized, double-masked, placebo-controlled, 2 arm, clinical trial.. The purpose of the study is to compare the effect of salsalate or placebo on sub-acute inflammation and coronary plaque, in people with cardiovascular disease. Participants are randomized to active intervention (salsalate) or placebo interventions for a period of 30 months. The primary endpoint is change in plaque volume in the coronary arteries assessed by MDCTA from baseline to 30 months. ...
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Bismuth subsalicylate is an antacid and anti-diarrhea medication. Bismuth subsalicylate is used to treat diarrhea, nausea, heartburn, indigestion, and upset stomach. Bismuth subsalicylate may also be used for purposes not listed in this medication guide.
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Bismuth subsalicylate is an antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
Leader Stomach Relief with NDC 70000-0439 is a a human over the counter drug product labeled by Cardinal Health. The generic name of Leader Stomach Relief is bismuth subsalicylate.
Stomach Relief with NDC 55319-736 is a a human over the counter drug product labeled by Family Dollar (family Wellness). The generic name of Stomach Relief is bismuth subsalicylate.
The therapeutic effect of bismuth subsalicylate BSS Pepto-Bismol in Clostridium difficile colitis was studied in golden Syrian hamsters. C. difficile was fed to the hamsters by orogastric intubation 2-3 days after their arrival. Clindamycin 1.5 mg per animal was given intraperitoneally 4 days l
Bismuth subsalicylate can be useful in the prevention and treatment of travelers diarrhea. Antibiotic prophylaxis is not routinely recommended. Treatment is typically with a fluoroquinolone or azithromycin. One recommended fluid replacement is: 1L of water with 1/2 tsp salt, 1/2 tsp baking soda, and 4 tbsp sugar ...
TY - JOUR. T1 - Effects of bismuth subsalicylate and encapsulated calcium ammonium nitrate on ruminal fermentation of beef cattle. AU - Henry, Darren D.. AU - Ciriaco, Francine M.. AU - Araujo, Rafael C.. AU - Fontes, Pedro L.P.. AU - Oosthuizen, Nicola. AU - Mejia-Turcios, Sebastian E.. AU - Garcia-Ascolani, Mariana E.. AU - Rostoll-Cangiano, Lautaro. AU - Schulmeister, Tessa M.. AU - Dubeux, Jose C.B.. AU - Cliff Lamb, G.. AU - DiLorenzo, Nicolas. N1 - Funding Information: This material is based upon work that is supported by the Foundational Program (Grant no. 2016-08402) and the Agriculture and Food Research Initiative-Food, Natural Resources and Human Sciences Education and Literacy Initiative (Award no. 2017-67011-26063) from the United States Department of Agriculture National Institute of Food and Agriculture. We wish to thank Quality Liquid Feeds for donating the molasses used in this experiment, Westway Feed Products for donating the urea used in this experiment, and GRASP Ind. & Com. ...
Bismuth Subsalicylate Suspension official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Learn everything you need to know about bismuth subsalicylate (kaopectate) and its nursing considerations incluing classification and common side effects
A Major Drug Interaction exists between bismuth subsalicylate and Diamox. View detailed information regarding this drug interaction.
High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion products of otoacoustic emission (DPOAE). These results suggest that ICA-105665
Thiosalicylic acid sodium salt/AFI134236 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Benzyl Salicylate (benzyl ortho hydroxy benzoate) is an almost colourless liquid that has a mild balsamic, sweetly floral note possessing excellent blending capabilities. Often used ~like foundation is for make-up~ as a base for heavy florals such as ylang, gardenia, jasmine, lily etc. It is also used in functional products such as soap, shampoo and fabric softener. Along with Methyl Salicylate, salicylates turn the most banal floral composition into a real perfume, with majestic weight and sweep divulges Luca Turin. However some people are anosmic to it, including some perfumers. Guy Robert could not smell benzyl salicylate at all, but could instantly recognize its presence in perfume: I recognize it as if it were a friend seen from behind in a crowd, by the cut of his shoulders. Indeed in the words of nose Bernand Chant it produces a diffusing, blooming effect very pleasing to the public. Many orchid fragrances are built on salicylates, while the mysterious emerald glow of the vintage Je ...
This study was designed to determine the dose of salicylate necessary to produce substantial antipyresis, and to determine the relationship between the response to salicylate and prostaglandin infused into the same region of the preoptic area of the rabbit. The effect of preoptic infusions of three doses of sodium salicylate, or a control solution, on the fever produced by an intravenous injection of endogenous pyrogen was measured. The pyrogenic response to prostaglandin E1 injected into the same preoptic sites in the same rabbits was also monitored. The results showed that the 50 μg/μL per hour dose of salicylate did not produce significant antipyresis but that the 100 and 200 μg/μL per hour doses did. The results also showed a significant correlation between the magnitude of fever produced by prostaglandin E1 and the magnitude of antipyresis produced by sodium salicylate at a particular site. Those sites at which infusion of salicylate produced the most effective antipyresis were also the ones at
If youre interested in forensic toxicology and are trying to determine the presence of salicylate by using a visual colorimetry, then look no further. This indepth and compelling video takes you into world of salicylate determination. Salicylate determination with visual colorimetry, Part I Using iron(III) nitrate to determine salicylate concentration in standardized salicylate solutions and urine. You can actually use any iron(III) salt, such as ferric chloride, ferric ammonium sulfate, and so on. Concentration is not critical
3. Helidac (Bismuth Subsalicylate/Metronidazole/Tcn) Bismuth subsalicylate is a mild antibiotic. Helitene (Collagen Topical) Helixate FS (Antihemophilic Factor) Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot
Take this medicine by mouth. Follow the directions on the label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be used in children as young as 12 years for selected conditions, precautions do apply.. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
This medication is typically used 4 times a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Generally, it is used only as needed. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food. It is recommended to drink plenty of water while using this medication. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness.. Drink plenty of clear fluids to help prevent dehydration caused by diarrhea.. ...
This information from Lexicomp® explains what you need to know about this medication, including what its used for, how to take it, its side effects, and when to call your healthcare provider.
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Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. Do not treat diarrhea for more than 2 days without talking to your doctor or health care professional. Call your doctor or health care professional as soon as you can if you get a fever, or nausea and vomiting. These could be symptoms of a more serious illness ...
Looking for online definition of phenyl salicylate in the Medical Dictionary? phenyl salicylate explanation free. What is phenyl salicylate? Meaning of phenyl salicylate medical term. What does phenyl salicylate mean?
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Salicylate is produced by many plants and microbes and is widely distributed in nature. It has a variety of biological activities, most notably its role in human medicine as a member of an important anti-inflammatory drug class. Salicylate acts as a regulatory molecule for bacteria (49). The biosynthesis and natural degradation pathways of this simple organic molecule have been well studied. In this work, we have identified a salicylate degradation cluster (sdgABCDEFGHR) in Streptomyces sp. strain WA46 and shown that salicylate is initially converted to gentisate via salicylyl-CoA and gentisyl-CoA (Fig. 2 and 3A). Salicylate is presumably converted to salicylyl-CoA via salicylyl-AMP by the action of SdgA and SdgB. AMP ligases are key components in the biosynthesis of antibiotics and siderophores, in which specific substrates are activated by AMP addition (12, 20, 34, 50, 53); the activated adduct binds to the thiol group of biosynthetic enzymes or to an acyl carrier protein. We were unable to ...
Several embryotoxic agents, which includes sodium salicylate, were reported to induce vertebral variations in the form of supernumerary ribs (SNR) when administered to pregnant rodents. Because the biological significance of SNR in toxicological studies is still a matter of debate, we investigated the molecular basis of this defect by analyzing the possible involvement of Hox genes, known to specify vertebrae identity. Sodium salicylate (300mg/kg) was administered to pregnant rats on gestational day 9 (GD 9). On GD 13, the expression of several Hox genes, selected according to the position of their anterior limit of expression, namely upstream (Hoxa9), at the level (Hoxa10) and downstream (Hoxd9) to the morphological alteration, were analyzed. Posterior shifts in the anterior limit of expression of Hoxa10 and Hoxd9 were observed following exposure to salicylate, which could explain an effect at the level of the axial skeleton. This finding suggests that the appearance of ectopic ribs can be ...
Prevention of Human Immunodeficiency Virus Type 1 Trans-mission by Pharmaceuticals Targeted to Host Proteins Re-quired for Virus Infection? Consideration of Farnesyl Thiosalicylic Acid, a Ras Inhibitor Abstract.
TY - JOUR. T1 - Salicylate degradation by a cold-adapted Pseudomonas sp. AU - Ahn, Eunsol. AU - Choi, Ki Young. AU - Kang, Beom Sik. AU - Zylstra, Gerben J.. AU - Kim, Dockyu. AU - Kim, Eungbin. N1 - Publisher Copyright: © 2017, Springer-Verlag Berlin Heidelberg and the University of Milan. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Pseudomonas sp. strain MC1 was characterized as a cold-adapted, naphthalene-degrading bacterium that is able to grow in a broad temperature range of 5-30°C. MC1 harbors a catabolic plasmid, designated pYIC1, which is almost identical to the archetypal NAH7 plasmid from the mesophilic bacterium Pseudomonas putida G7. On pYIC1, the catabolic genes for naphthalene degradation are clustered in two operons: nahAa-Ab-Ac-Ad-B-F-C-Q-E-D encoding the conversion of naphthalene to salicylate, and nahG-T-H-I-N-L-O-M-K-J encoding the conversion of salicylate through meta-cleavage pathway to pyruvate and acetyl CoA. NahH, ...
The chemical formula for sodium salicylate is C7H5NaO3. All of the numbers in the chemical formula for sodium salicylate are subscript numbers in accordance with standard chemical formula...
Credit: Unsplash/CC0 Public Domain Concerns have been raised that the use of a common group of medications called RAS inhibitors could facilitate SARS-CoV-2 infection, impact COVID-19 disease severity, and worsen prognosis. However, in a new nationwide registry-based study from Karolinska Institutet in Sweden, including almost 1.4 million patients, use of RAS inhibitors was not associated with increased risk of hospitalization or death from COVID-19. The study has been published in the European Journal of Heart Failure. The new coronavirus SARS-CoV-2 enters human cells by binding its outer spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the target cells. Because renin-angiotensin-aldosterone-system (RAS) inhibitors increase ACE2 levels, concerns regarding the use of these treatments during the COVID-19 pandemic have been raised. The generic names of RAS inhibitors end in pril or sartan (some examples are enalapril, kaptopril, losartan
TY - JOUR. T1 - Salicylate uniquely induces a 27-kDa protein in tubercle bacillus. AU - Sun, Zhonghe. AU - Cheng, Shao Ji. AU - Zhang, Hao. AU - Zhang, Ying. PY - 2001/9/25. Y1 - 2001/9/25. N2 - Salicylate was found to uniquely induce a 27-kDa protein in Mycobacterium tuberculosis complex organisms but not in Mycobacterium smegmatis or Escherichia coli. The structural analogue antitubercular para-amino-salicylate also induced the 27-kDa protein but to a somewhat lower level than salicylate. Other structural analogues such as benzoic acid and acetyl salicylic acid (aspirin) did not induce the 27-kDa protein. Western blot analysis indicated that the 27-kDa protein was localized mainly in the cytoplasm. The 27-kDa protein was not expressed at different growth phases in the absence of salicylate. The 27-kDa protein was identified as a putative benzoquinone methyltransferase (Rv0560c), which has several homologues in the M. tuberculosis genome. The cloned 27-kDa gene was found to express ...
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5-AMINO-3-SULFOSALICYLIC ACID | C7H7NO6S | CID 22574 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
A bismuth compound, bismuth oxychloride, is used in some cosmetics to give either a matte or a shiny finish depending on particle size. Other bismuth compounds, bismuth(III) oxide and bismuth subcarbonate, are used in fireworks to give crackling effects. These compounds are formed into granules, the rapid combustion of which gives the crackling effect.. Bismuth-containing compounds are also found in medicines to treat stomach aches and diarrhoea. The best-known example is Pepto-Bismol (bismuth subsalicylate), an antacid.. Remember, you can keep track of all of the previous entries in this series on the site here, or on the Royal Society of Chemistrys dedicated page.. ...
In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PLpro). Moreover, our study demonstrated that the two hit compounds are dual inhibitors targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CLpro) in addition to PLpro. A mechanism of action study using enzyme kinetics further characterized the two compounds as irreversible inhibitors against both 3CLpro and PLpro. Significantly, both identified compounds inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations. Our finding provides two novel natural products as promising SARS-CoV-2 antivirals.
BioAssay Systems salicylate detection kit provides a convenient and reliable means to measure salicylate. In the assay, salicylate complexes with ferric chloride to create a colored compound that can be measured at 560 nm. This assay can be used with a variety of samples and is simple, sensitive, and adaptable to high-throughp
i) Dealing with the potential for toxicity with local application, especially in infants:. As choline salicylate is absorbed across the buccal mucosa, the possibility exists for toxicity, especially in infants hence the need for caution not to exceed the stated dose and monitor for any signs of suggested salicylism.. Symptoms: Nausea, vomiting, tinnitus, hyperventilation, high fever, confusion, dehydration, disorientation, dizziness, coma and/or convulsions are common. Gastrointestinal haemorrhage is frequent. Some degree of acid-base disturbance is present in most cases.. ii) Dealing with overdose in the event of accidental ingestion of product:. Serum salicylate levels above 3.6 mmol/l in adults (2.2 mmol/l in children) are likely to be toxic and levels of 5.4 mmol/l or above are fatal.. Treatment: Drug absorption can be stopped by induced vomiting or gastric lavage within an hour of ingestion. Activated charcoal is to be given by mouth if the patient is suspected of ingesting more than ...
If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Minocycline. Check with your doctor if you have questions ...
If you also take bismuth salts (eg, bismuth subsalicylate), calcium salts (eg, calcium carbonate), colestipol, iron salts (eg, iron sulfate), magnesium, urinary alkalinizers (eg, daily antacids), sucralfate, vitamins/minerals, quinapril, didanosine, or zinc salts (eg, zinc sulfate), do not take them within 2 to 3 hours before or after taking Minocin . Check with your doctor if you have questions ...
American Diabetes Association and the American Dietetic CEREALS/GRAINS/PASTA *Bran cereals concentrated (such as Bran Buds All Bran) Ingredient List: Active Ingredient: Bismuth subsalicylate 525 mg Inactive Ingredients: benzoic acid or pharmacist before use if you are taking any drug for: anticoagulation (thinning the blood) diabetes gout arthritis. Blood Glucose and Hormones - Insulin and Glucagon Antagonistic hormones 3. Cure Pancreatic Cancer Ribbon medication Diabetes Causes Fatigue :: Type 2 Diabetes Research For Cures - The 3 Step Trick that Reverses Diabetes Permanently in type 1 diabetes and gluten free diet As Little as 11 Days. en la historia evolutiva de la enfermedad al curar Health Concern On diagnosis or treatment.. Learn about their use side effects and safety warnings. There are several different types of rice including long-grain basmati black rice white rice and diabetes Brown Rice: Health Benefits & Nutrition Anti-phospho-Insulin Receptor Antibody clone 21G12 is an antibody ...
For H. pylori infection and duodenal ulcer (taken with an H2 blocker): Adults-One dose (two 262.4 milligrams [mg] of bismuth subsalicylate, one 250 mg of metronidazole, and one 500 mg of tetracycline) 4 times a day, taken with meals and at bedtime, for 14 days. Children-Use and dose must be determined by your doctor ...
Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT
A recently published report describes the case of a 62-year-old female patient with underlying cirrhosis who experienced coagulopathy secondary to bismuth subsalicylate (BSS) poisoning.
On the other hand, its not so long ago (Mid 1980s I think), that after centuries of using salicylates as fever remedies, the ...
Bismuth salicylate for the stomach, cough medicine, a light aperient calomel, and a strong one, unspecified; quinine sulphate, ...
Benzyl Salicylate**. *=certified organic. **=as a component part of pure essential oils. Free from synthetic fragrances, no ... Benzyl Salicylate**. *=certified organic. **=as a component part of pure essential oils. Free from synthetic fragrances, no ...
Octyl Salicylate (Sunscreen), Butylene Glycol (Humectant), Butyl Methoxydibenzoylmethane (Sunscreen), Ethyl Trisiloxane (Skin- ... Aqua (Solvent/Diluent), Ethylhexyl Methoxycinnamate (Sunscreen), Octyl Salicylate (Sunscreen), Butylene Glycol (Humectant), ... Benzyl Salicylate (Fragrance Ingredient), Potassium Sorbate (Preservative), Citric Acid (pH Adjuster), Ascorbic Acid ( ...
Phenyl Salicylate - (Salol) (125G). *MERCURY STANDARD SOLUTION 1ML=0.1MG (100ML). *IODINE 0.0473 NORMAL (4L) ...
Phenyl Salicylate - (Salol) (125G). *MERCURY STANDARD SOLUTION 1ML=0.1MG (100ML). *IODINE 0.0473 NORMAL (4L) ...
  • Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. (
  • Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. (
  • Methyl salicylate can be poisonous in large amounts. (
  • Other products may also contain methyl salicylate. (
  • Below are symptoms of a methyl salicylate overdose in different parts of the body. (
  • Methyl salicylate is the most poisonous form of the salicylate type of chemicals. (
  • Greene T, Rogers S, Franzen A, Gentry R. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. (
  • Methyl salicylate exposure in toddlers. (
  • Its strong and pungent flavour comes from enhanced natural component, methyl salicylate , and such tea is highly reputed in some gourmet tea market worldwide. (
  • If you have an aching muscle or joint, you might rub on a topical rubefacient, products containing menthol or camphor (with or without methyl salicylate ) that provide a cooling sensation or a feeling of warmth. (
  • Aspirin is the most common salicylate, but there are others, including methyl salicylate, which is found as oil of wintergreen in some muscle ache creams. (
  • Methyl salicylate creams and topical forms of aspirin are absorbed into the body through the skin. (
  • Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. (
  • For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. (
  • Molecular weight 152.15 Definition Methyl salicylate contains not less than 98 per cent. (
  • Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. (
  • Ask a doctor or pharmacist about using methyl salicylate topical if you have any allergies (especially to aspirin or other salicylates), or if you have a serious medical condition. (
  • It is not known whether methyl salicylate topical will harm an unborn baby. (
  • It is not known whether methyl salicylate topical passes into breast milk or if it could harm a nursing baby. (
  • Do not apply methyl salicylate topical to your breast area if you are breast-feeding a baby. (
  • How should I use methyl salicylate topical? (
  • Make sure your skin is clean and dry before you apply methyl salicylate topical. (
  • To apply a methyl salicylate topical skin patch , remove the liner and apply the patch to your skin over the area of pain. (
  • Methyl salicylate topical may be used up to 4 times daily or as directed on the medicine label. (
  • Wash your hands with soap and water immediately after applying methyl salicylate topical or handling the skin patch. (
  • Methyl salicylate can cause a cold or burning sensation wherever it is applied. (
  • Avoid applying methyl salicylate right after bathing or shaving. (
  • Since methyl salicylate topical is used as needed, it does not have a daily dosing schedule. (
  • Call your doctor promptly if your symptoms do not improve after using methyl salicylate topical. (
  • What should I avoid while using methyl salicylate topical? (
  • Also known as 2-hydroxybenzoic acid, salicylic acid occurs naturally in the bark of the willow tree, Salix alba , and methyl salicylate is present in wintergreen leaves, Gaultheria procumbens , and in sweet birch bark, Betula lenta . (
  • Iodex with Methyl Salicylate , 1 oz. (
  • Iodex with Methyl Salicylate relieves local congestion. (
  • The Iodex with Methyl Salicylate has been wonderful for my wonky knee. (
  • IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains, soreness and stiffness of muscles. (
  • Many major brands of mouthwash contain essential oils and therefore salicylic acid, or it may list it as methyl salicylate, menthol, or other plant extracts. (
  • In 2007, a teen was reported as dead due to overdosing on methyl salicylate after rubbing her sore thigh muscle with a pain reducing cream, Bengay. (
  • M.J.H. Smith, A.W. Ford-Hutchinson and P.C. Elliott , Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate , J. Pharm. (
  • Fourth, the data on the role of sodium bicarbonate in the management of salicylate poisoning will be provided. (
  • Sodium Salicylate has analgesic, anti-inflammatory and antipyretic action. (
  • The principal use of Sodium Salicylate is in the treatment of acute rheumatic fever. (
  • Sodium salicylate is contra-indicated in the presence of severe renal disease. (
  • Sodium Salicylate is a gastric irritant and sodium bicarbonate is often given with it to reduce this effect (however the bicarbonate also increases rate of excretion and this lowers the concentration of salicylate in the blood). (
  • Patients suffering from severe intoxication (a plasma-salicylate concentration above 500 mg/mL in adults or 300 mg/mL in children) should be given gastric lavage together with forced diuresis by I/V infusions of saline with sodium bicarbonate or of compound sodium lactate injection or dextrose solution. (
  • Infusion of sodium salicylate (50.0 or 100.0 μg/μl) into the ventral septal area (VSA) of the rat brain suppressed Prostaglandin-E 1 -induced hyperthermia. (
  • These results are consistent with the notion that sodium salicylate infusions within the VSA enhance AVP action and thus bring about the attenuation of PGE-induced hyperthermia. (
  • Alexander SJ, Cooper KE, Veale WL (1987) Blockade of prosta-glandin E 1 hyperthermia by sodium salicylate given into the ventral septal area of the rat brain. (
  • Cranston WI, Rawlins MD (1972) Effects of intracerebral microinjection of sodium salicylate on temperature regulation in the rabbit. (
  • Hori T, Nakashima T, Kiyohara T, Shibata M (1984) Effects of leukocytic pyrogen and sodium salicylate on hypothalamic neurons in vitro. (
  • What Is the Chemical Formula for Sodium Salicylate? (
  • All of the numbers in the chemical formula for sodium salicylate are subscript numbers in accordance with standard chemical formula notation. (
  • Sodium salicylate is used as a pain reliever as well as to reduce or prevent fever, and it works by inhibiting the enzyme cyclooxygenase, also known as COX. (
  • However, aspirin can cause gastrointestinal bleeding in susceptible individuals, so sodium salicylate is used as an alternative drug. (
  • The effectiveness of sodium salicylate is less than that of aspirin in equal doses. (
  • What Are the Medical Uses of Sodium Salicylate? (
  • Sodium salicylate has been used for medical purposes for hundreds of years. (
  • Sodium salicylate is one of the oldest fever reducing NSAIDs available. (
  • When sodium salicylate is used as a nonsteroidal anti-inflammatory drug, it works to reduce pain and inflammation in the body. (
  • People who are sensitive to aspirin may be directed to take sodium salicylate. (
  • Since sodium salicylate may be used as an analgesic, it is often recommended for people with body, muscle, or joint pain. (
  • Both homeopathic medicine practitioners and scientific studies have indicated that sodium salicylate may be helpful for people affected by rheumatism or rheumatoid arthritis . (
  • Sodium salicylate can be used to treat dandruff. (
  • As a result, people affected with a wide variety of fungal issues may use sodium salicylate. (
  • Sodium salicylate may be helpful for people with rheumatoid arthritis. (
  • Because side effects, such as gastrointestinal irritation, are possible, a medical provider should be consulted before using sodium salicylate. (
  • Sodium salicylate, an anti-inflammatory drug, may benefit people who are afflicted with joint and muscle pain. (
  • Regular use of large amounts of sodium salicylate (as for arthritis) can add a large amount of sodium to your diet. (
  • Sodium salicylate contains 46 mg of sodium in each 325-mg tablet and 92 mg of sodium in each 650-mg tablet. (
  • Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate may also be used for purposes not listed in this medication guide. (
  • You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, phenyl salicylate, or sodium biphosphate. (
  • Not all salicylates have the word salicylate in their name--though some do, like magnesium salicylate and sodium salicylate. (
  • High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. (
  • Aspirin, with sodium salicylate as an active ingredient, is one of the most widely used analgesic, anti-inflammatory, and antipyretic drugs ( 1 ). (
  • Sodium salicylate at a high dose (1-10 mM) can induce a moderate, reversible cochlear hearing loss (~20-40 dB threshold elevation), tinnitus, and suppression of otoacoustic emissions (OAEs) ( 2 , 3 ). (
  • Methenamine and sodium salicylate is a combination medicine that is used to relieve symptoms of bladder infection or irritation, such as painful or burning urination, or feeling an urgent or more frequent need to urinate. (
  • You should not use this medicine if you are allergic to methenamine, sodium salicylate, or aspirin. (
  • Ask a doctor before using methenamine and sodium salicylate to treat painful or frequent urination if you've never had these symptoms before. (
  • Do not give methenamine and sodium salicylate to a child younger than 12 without medical advice. (
  • Can I take Methenamine And Sodium Salicylate(Oral) if I'm pregnant or breastfeeding? (
  • They may contain ingredients similar to methenamine and sodium salicylate (such as aspirin, ibuprofen, ketoprofen, or naproxen). (
  • Use Methenamine And Sodium Salicylate(Oral) exactly as directed on the label, or as prescribed by your doctor. (
  • Polarised light micrograph of potassium salicylate, C7H5NaO3, (potassium 2-hydroxybenzoate), an analgesic and antipyretic drug. (
  • Some medical conditions may interact with acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine. (
  • Ask your health care provider if acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine may interact with other medicines that you take. (
  • What is the most important information I should know about magnesium salicylate? (
  • An overdose of magnesium salicylate can be fatal. (
  • Magnesium salicylate may cause stomach or intestinal bleeding, which can be fatal. (
  • These conditions can occur without warning while you are using magnesium salicylate, especially in older adults. (
  • What is magnesium salicylate? (
  • Magnesium salicylate is a salicylate (sa-LIS-il-ate). (
  • Magnesium salicylate may also be used for purposes not listed in this medication guide. (
  • What should I discuss with my healthcare provider before taking magnesium salicylate? (
  • Magnesium salicylate can cause Reye's syndrome, a serious and sometimes fatal condition in children. (
  • Magnesium salicylate is not approved for use by anyone younger than 12 years old. (
  • Taking magnesium salicylate during late pregnancy may cause bleeding in the mother or the baby during delivery. (
  • Magnesium salicylate can pass into breast milk and may harm a nursing baby. (
  • How should I take magnesium salicylate? (
  • Take with food if magnesium salicylate upsets your stomach. (
  • If you need surgery, tell the surgeon ahead of time that you are using magnesium salicylate. (
  • Since magnesium salicylate is used when needed, you may not be on a dosing schedule. (
  • What should I avoid while taking magnesium salicylate? (
  • Avoid drinking alcohol while you are taking magnesium salicylate. (
  • Many medicines available over the counter contain aspirin or other medicines similar to magnesium salicylate. (
  • What are the possible side effects of magnesium salicylate? (
  • There are no evaluations for Magnesium Salicylate. (
  • Magnesium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). (
  • You should not take this medication if you are allergic to acetaminophen (Tylenol), magnesium salicylate (Nuprin), pamabrom, aspirin or other NSAIDs. (
  • Magnesium salicylate may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. (
  • Do not take acetaminophen, magnesium salicylate, and pamabrom without telling your doctor if you are pregnant or plan to become pregnant during treatment. (
  • Magnesium salicylate is an aspirin-like drug used to relieve mild to moderate pain. (
  • an allergy to salicylates (such as aspirin, choline magnesium trisalicylate, magnesium salicylate). (
  • What are the risks of taking magnesium salicylate? (
  • Risks of taking magnesium salicylate include: harm to your fetus if you are pregnant, possible harm to your nursing baby if you are breastfeeding, interference with blood clotting and low blood sugar if you are diabetic or receiving hemodialysis. (
  • It is possible that use of magnesium salicylate can impede blood clotting or lead to unusual bleeding. (
  • Menthol, mint, benzoates, and beta-hydroxy acid are a few of the different names of salicylate compounds. (
  • Lewis TV, Badillo R, Schaeffer S, Hagemann TM, McGoodwin L. Salicylate toxicity associated with administration of Percy medicine in an infant. (
  • Salicylate toxicity model of tinnitus. (
  • Delayed Salicylate Toxicity in a 17-Year-Old Girl With Initially Undetectable Salicylate Concentration 3.9 Hours After Ingestion. (
  • Salicylate toxicity may result from acute or chronic ingestion of acetylsalicylic acid (aspirin is a generic name in the United States but a brand name in the rest of the world). (
  • If too much salicylate is ingested at one time ( acute toxicity) or too much is taken over a period of time ( chronic toxicity), and/or if the body's ability to remove the salicylates is reduced, then signs and symptoms associated with toxicity will begin to emerge. (
  • The symptoms of acute salicylate poisoning may be minimal initially with severe toxicity not evident until 6-12 hours. (
  • No convincing data support the use of repeated doses of activated charcoal in salicylate toxicity. (
  • Following its review the MHRA concluded that the symptoms described in this case could not be considered to be Reye's syndrome and were more likely due to salicylate toxicity from overuse of the product. (
  • If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (
  • Hyoscyamine, methenamine, methylene blue, and phenyl salicylate is a combination medicine used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. (
  • Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (
  • If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (
  • What are the possible side effects of hyoscyamine, methenamine, methylene blue, and phenyl salicylate? (
  • Absorption of salicylate powders versus tablets following overdose: a poison center observational study. (
  • Salicylate testing measures the concentration in the blood to detect and/or monitor an overdose (salicylate poisoning). (
  • Salicylate sensitivity varies - some people improve just by cutting down, some people have to avoid high salicylate foods, and some people are only affected by an overdose of salicylate medications. (
  • Reye's syndrome and salicylate use. (
  • 05). It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome. (
  • Aspirin (and salicylates) has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chicken pox and influenza. (
  • Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition in children. (
  • Medsafe's review found no evidence linking Reye's syndrome to the use of topical oral choline salicylate containing products. (
  • This is very important because salicylates may cause a serious illness called Reye's syndrome in children and teenagers with fever caused by a virus infection, especially flu or chickenpox. (
  • In New Zealand three topical products for oral use contain choline salicylate: Bonjela Teething Gel, Bonjela Mouth Ulcer Gel and Ora-sed gel. (
  • Medsafe's advice follows a review of the recent decision by the United Kingdom Medicines and Healthcare products Regulatory Agency (MHRA) to contraindicate the use of all topical oral choline salicylate gels in children under 16 years of age. (
  • I have celiac disease, a salicylate intolerance AND milk allergy. (
  • While salicylate sensitivity, also known as salicylate intolerance, is not as common as gluten or lactose intolerance, it's a real issue for some people. (
  • Compared to foods, medications like aspirin contain high amounts of salicylates, which is why salicylate intolerance is most commonly linked to medications. (
  • The buildup of leukotrienes in the body leads to symptoms related to salicylate intolerance. (
  • Although the percentage of people who have a salicylate intolerance is unknown, it is more common in adults who suffer from asthma ( 5 ). (
  • Summary People with salicylate intolerance are unable to consume even small amounts of these chemicals without experiencing negative side effects. (
  • In my experience, most people with salicylate intolerance have no idea what could be affecting them. (
  • I was told in my 30s that I had genetic salicylate intolerance but given no more info. (
  • About 10 years ago I found the Australian salicylate list (I'm in the U.S.) I'm now 71 yrs and my gut intolerance is getting worse. (
  • You may not even be aware that you have salicylate sensitivity, salicylate intolerance or salicylate allergy. (
  • Salicylates are compounds found in foods, medications and other products that can cause adverse reactions in those who are intolerant. (
  • Salicylates are just one group of the hundreds of compounds in foods that can have varying effects on us, depending on how much we eat and how sensitive we are. (
  • Experiments using radiolabeled chloramphenicol and salicylate demonstrated active efflux of both compounds in the presence of the gene cluster. (
  • Salicylate is clearly separated from the other two compounds, which move together with only partial resolution (Fig. 1). (
  • Remove the skin of chicken because it is high in amines and avoid aged meat because of its high salicylate, amine and glutamate content. (
  • Patients will avoid foods from the 'high salicylate' group completely. (
  • Salicylates are chemicals found in plants and are a major ingredient in aspirin and other pain-relieving medications . (
  • Because the use of salicylates such as aspirin for children with influenza and chickenpox has been associated with Reye syndrome, the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. (
  • advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox. (
  • This fact became evident when several guardians of our patients came in within a few days of each other in late November to early December unaware of the dangers of giving their children aspirin and other salicylate medications. (
  • Salicylates are chemicals found naturally in certain foods and also synthetically produced for use in medications and other products. (
  • Salicylates are a group of drugs, including aspirin, available as both prescription and non-prescription (over-the-counter) medications. (
  • Salicylates are also found in medications, fragrances, industrial chemicals, plastics and some pesticides, and can cause adverse effects when inhaled as well as eaten. (
  • Salicylate levels are also measurable in individuals not taking aspirin or salicylate medications ( 9 , 11-14 ). (
  • Phenyl salicylate is a mild pain reliever. (
  • This article explains the causes and symptoms of salicylate sensitivity, including which foods to avoid. (
  • What are some of the symptoms of salicylate sensitivity? (
  • Methods: A tinnitus model was established in rats through intraperitoneal injection of salicylate (SA). (
  • Salicylate, the active component of aspirin, is known to induce tinnitus. (
  • However, the site and the mechanism of generation of tinnitus induced by salicylate remains unclear. (
  • Mefenamate in place of salicylate also increased the number of false positive responses, suggesting that salicylate-induced tinnitus is related to an inhibition of cyclooxygenase. (
  • Application of NMDA antagonists into the perilymphatic fluids of the cochlea blocked the increase in pole-jumping behavior induced by salicylate, suggesting that salicylate induces tinnitus through activation of cochlear NMDA receptors. (
  • Has anyone else experienced pulsatile tinnitus from salicylates? (
  • You should not use this medicine if you are allergic to salicylates (such as aspirin) or other nonsteroidal anti-inflammatory drugs (NSAIDs). (
  • The active and major component in aspirin/NSAIDs is salicylate, which is also found naturally in some foods. (
  • Diet is known to be a source of salicylates, including fruits, vegetables, and meat. (
  • especially, if the source of salicylates is in a concentrated form like aspirin. (
  • However, the association between serum salicylate level and recurrence of adenoma in nonusers of aspirin has not been studied. (
  • We measured serum salicylate levels in participants in a randomized controlled trial with calcium supplementation for the prevention of colorectal adenomas. (
  • We did not find an association with recurrence of adenomas or advanced adenomas with serum salicylate levels at year 1 among nonusers of aspirin. (
  • Among nonusers of ASA, serum salicylate levels are not associated with risk of recurrence of adenomas. (
  • Serum salicylate levels can be detected in individuals not taking aspirin, but the levels may be too low to confer protection from risk of recurrent adenomas. (
  • ASA), is readily detected in serum and urine of humans and is a measure of salicylates, whether from ASA use or from diet and endogenous sources. (
  • These include certain colonic bacteria species that may have the ability to synthesize SA, and synthesis of SA via metabolism of hippuric acid, a metabolite of benzoic acid demonstrated to be formed endogenously in man ( 18 ) The associations of serum salicylate levels, in particular among nonusers of aspirin, in reducing risk of colorectal adenoma are not known. (
  • The aim of our study was to determine whether serum salicylate levels among individuals with history of prior adenoma are associated with risk of colorectal adenoma in individuals not taking aspirin. (
  • These studies conducted by state health departments suggest an association between prior ingestion of aspirin and other salicylates and Reye syndrome. (
  • Aspirin and other salicylates are most often used to reduce pain , fever , and inflammation. (
  • But aspirin and other salicylates are usually safe and effective for adults when taken at the proper dose. (
  • Vantelin's odorless liquid is the company's "halo product," utilizing 10% trolamine salicylate to relieve aches and pains. (
  • While TEA-Salicylate is also an FDA-approved over-the-counter active sunscreen ingredient, its use today is very limited or non-existent (see Safety Information tab). (
  • The U.S. Food and Drug Administration (FDA) approved TEA-salicylate (trolamine salicylate) for use as an active sunscreen ingredient in over-the-counter (OTC) sunscreen drug products at concentrations up to 12 percent. (
  • Accordingly, FDA proposed trolamine salicylate be classified as a Category II (i.e., not GRASE) sunscreen active ingredient, due to safety concerns. (
  • If this proposed rule becomes final, sunscreen products in the marketplace would no longer be allowed to contain trolamine salicylate as an active ingredient. (
  • The safety of salicylic acid and its salts and esters, including TEA-salicylate, has been assessed by the Cosmetic Ingredient Review ( CIR ) Expert Panel on several occasions. (
  • However, per CIR standard procedure, the use of TEA-salicylate as a sunscreen ingredient was not included in the review (CIR does not review the active ingredients in over-the-counter drugs). (
  • As before, the review of TEA-salicylate did not include its use as an active sunscreen ingredient. (
  • TEA-salicylate is not approved as an active sunscreen ingredient in the EU. (
  • FDA was concerned that use of trolamine salicylate as an active ingredient in sunscreens could cause serious detrimental health effects due to the anti-coagulation effects of salicylic acid. (
  • People with a low tolerance may have an allergic reaction if they get more than a small amount of salicylate. (
  • If you're allergic to salicylates, you'll need to avoid items that have them. (
  • If prone to allergic reaction from aspirin or salicylates, consult a doctor before use. (
  • I found a table with a list of salicylates and all the items I had previously been told I was "allergic to" were listed as high in salicylates. (
  • Kirshenbaum LA, Mathews SC, Sitar DS, Tenenbein M. Does multiple-dose charcoal therapy enhance salicylate excretion? (
  • 4.5 mEq/L). Urinary alkalization promotes the excretion of salicylate. (
  • Research shows that about 20% of adults with asthma 1 , 60% with of people with food-induced itchy rashes, headaches or migraines, 70% of people with irritable bowel symptoms 2 and 75% of children with behaviour problems 3 may be sensitive to salicylates. (
  • If a person is sensitive to salicylates, what kind of symptoms can they expect? (
  • Physostigmine Salicylate Injection is an antidote used to reverse the effect of drugs that cause anticholinergic syndrome. (
  • Our Physostigmine Salicylate Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (
  • Rauschka H, Aboul-Enein F, Bauer J, Nobis H, Lassmann H, Schmidbauer M. Acute cerebral white matter damage in lethal salicylate intoxication. (
  • Between our list of salicylates to avoid on Stage One, and the extended list included in the Handbook, you will find the most complete list available of salicylate-containing items, plus benzoate information since many salicylate-sensitive people are also sensitive to benzoates. (
  • The ability to remove salicylates efficiently is affected by the body's blood and urine pH (acidity/alkalinity) and by kidney function. (
  • Alkalization of the urine enhances elimination of salicylates through ion trapping in the renal tubules. (
  • Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. (
  • The salicylate content of blood and urine was shown to increase following consumption of a variety of meals, both vegetarian and meat-based, ranging from southern Indian dishes to European ones ( 15, 16 ). (
  • Salicylates, by inhibiting the synthesis of prostaglandins that occur in inflamed tissues, prevent the sensitization of the pain receptors to mechanical stimulation or to chemicals, such as bradykinin, that appear to mediate pain response. (
  • Salicylates are a group of chemicals derived from salicylic acid. (
  • However, those with a sensitivity to salicylates may experience side effects when they consume a food or use a product that contains even small amounts of these chemicals. (
  • Salicylates are chemicals that occur naturally in many plants - they're a kind of natural pesticide - to protect the plants against insects and diseases. (
  • Various sunscreen ingredients including octyl salicylate and oxybezone increases the asborption of other potentially harmful chemicals. (
  • Salicylates are chemicals found naturally in some plants, stored in the bark, leaves, roots, skin and seeds, where they protect the plants against insect damage and disease. (
  • Salicylates are natural chemicals produced by plants. (
  • What is the role of salicylates in the etiology of Reye syndrome? (
  • This test measures the amount of salicylates in the blood. (
  • The amount of salicylates that trigger a reaction can differ depending on the individual's ability to break them down. (
  • When these two medicines are taken together, the toxic effects of salicylates (e.g. aspirin) may increase. (
  • Children who do not have a virus infection may also be more sensitive to the effects of salicylates, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. (
  • Elderly people are especially sensitive to the effects of salicylates. (
  • People with a sensitivity to salicylates or any other substance can experience the exact same symptoms as a person with an allergy. (
  • The 2019 proposed rule concluded the risks associated with use of trolamine salicylate in sunscreen products outweighs its benefits. (
  • Trolamine salicylate (Aspercreme, Aspergel) is an organic compound which is the salt formed between triethanolamine and salicylic acid . (
  • The US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the Daily Med database that contain trolamine salicylate. (
  • [1] Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue. (
  • [2] However, one study reported that trolamine salicylate does penetrate into, and persist within, underlying muscle tissue. (
  • The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to induce muscle soreness. (
  • The experimenters observed that those using the trolamine salicylate product exercised longer before reporting the onset of soreness, reported less intense soreness, and reported that their soreness did not last as long as the people who used the placebo. (
  • All of the trolamine salicylate-containing products listed in the two cited references are 10% solutions. (
  • FDA's Preliminary Regulatory Impact Analysis reviewed more than 700 sunscreen brands sold in the United States, and indicated trolamine salicylate is no longer used in products marketed in the U.S. (
  • Based on an evaluation of all available scientific data, CIR concluded salicylic acid and 17 salicylate ingredients (including TEA-salicylate/ trolamine salicylate) are safe in cosmetics in the present practices of use and concentration, when formulated to be non-irritating and non-sensitizing to skin, which may be based on a quantitative risk assessment ( QRA ). (
  • Trolamine salicylate is comprised of trolamine and salicylic acid. (
  • FDA located two case reports of serious coagulation-related adverse events associated with liberal dermal application of trolamine salicylate. (
  • Morpholine salicylate is a nonsteroidal anti-inflammatory drug. (
  • Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. (
  • 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. (
  • Applied topically, benzyl salicylate can cause negative reactions, even in small amounts. (
  • In moderate to severe salicylate poisoning, consider decontamination (activated charcoal) and the early enhancement of elimination (urinary alkalisation with or without haemodialysis). (
  • Haemodialysis should be considered early in moderate to severe salicylate poisoning as urinary alkalisation can be difficult to achieve and may not be effective. (
  • If, however, you already have a diagnosis of severe salicylate sensitivity, or you have tried the Stage One diet with only partial improvement, it may be worth your while to try avoiding also those items listed on pages 51 through 57 in the Handbook. (
  • Salicylic acid and its salts (including TEA-salicylate) are listed in the Cosmetics Directive of the European Union and may be used as preservatives in cosmetics and personal care products at a maximum concentration of 0.5 percent (see Annex V, entry 3 ). (
  • TEA-Salicylate may be used in rinse-off cosmetic products without concentration restrictions and in leave-on products at a maximum concentration of 2.5 percent (see Annex III, entry 62 ). (
  • These results suggest that salicylate is a natural substrate for the efflux pump in B. cenocepacia and imply that the environment of low iron concentration in the cystic fibrosis lung can induce efflux-mediated resistance, even in the absence of antibiotic selective pressure. (
  • A more recent study found that at moderate concentrations (0.1-1 mM), salicylate also causes a concentration-dependent reversible reduction of a voltage-gated potassium channel, which is encoded by KCNQ4 gene of OHCs ( 10 ). (
  • Hamdan JA, Manasra K, Ahmed M. Salicylate-induced hepatitis in rheumatic fever. (
  • Over-the counter salicylates are used as needed or regularly to reduce pain, fever, and inflammation. (
  • Do not give aspirin or other salicylates to a child or a teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. (
  • The best known salicylate is aspirin (acetylsalicylic acid), which was originally extracted from willow bark. (
  • The Surgeon General notes that the FDA will notify health professionals through its Drug Bulletin, will develop lay-language information for widespread distribution, and will take the steps necessary to establish new labeling requirements for drugs containing salicylates. (
  • Other drugs may interact with physostigmine salicylate. (
  • We discuss our own experiences with children who were referred for care to the allergy clinics of three public hospitals, and who had previously used these diets, and review the evidence for using low salicylate diets in treating a variety of disease indications. (
  • We sought to identify the indications for which salicylate elimination is prescribed in Sydney by conducting a retrospective case note review of children attending the allergy clinics of the two main children's hospitals, Sydney Children's Hospital and the Children's Hospital at Westmead, as well as a major regional allergy clinic at Campbelltown Hospital, between 1 January 2003 and 31 December 2011. (
  • What is the evidence supporting the role of low salicylate diets for these indications? (
  • E. Quilley and M.J.H. Smith , The Application of Paper Partition Chromatography to the Study of the Metabolism of Salicylate in the Rat , J. Pharm. (
  • The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. (
  • The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. (
  • One physiological basis of salicylate ototoxicity is likely to originate from altered arachidonic acid metabolism. (
  • Proceedings: Kinetics of salicylate metabolism. (
  • Salicylate sensitivity can cause varied symptoms that mimic allergies and illness. (
  • If your frequent use skin care or personal care products contain any synthetic or natural form of salicylic acid, over time, you could develop salicylate sensitivity and eventually a variety of symptoms associated with salicylic acid allergies. (
  • Biological Data Biochemical aspects The orally administered ester undergoes very rapid and nearly complete hydrolysis in rats and dogs, salicylate being the only significant finding in the blood of rats 20 minutes after an intragastric dose, and in dogs within an hour of oral dosing. (
  • of salicylate as the ester being present in plasma after 90 minutes. (
  • The ester is potentially the most toxic salicylate for infants and children, as 4 ml can be fatal (Davison et al. (
  • Salicylic acid inhibits prostaglandin biosynthesis in vivo as the salicylate ion itself and there is no formation of a subsequent 'active' metabolite. (
  • One study demonstrated that salicylates decrease beta-oxidation of the long-chain fatty acid palmitate by cultured fibroblasts from children who recovered from Reye syndrome as compared with control subjects. (
  • After oral forms of salicylates are ingested, they are converted to salicylic acid, absorbed in the stomach and small intestine and transferred into the blood stream. (
  • The salts, esters of salicylic acids, or salicylate esters of an organic acid. (
  • The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives. (
  • If you regularly take a prescription salicylate, your doctor may want to collect blood just prior to your next dose (trough level). (
  • The dose of your salicylate medicine may need adjusting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. (
  • The association of salicylates with Reye syndrome is based upon evidence from epidemiologic studies that are sufficiently strong to justify this warning to parents and health care personnel. (
  • CDC, on the basis of its review of the available data and the recommendations of an advisory panel on February 12, 1982, stated that 'until definitive information is available, CDC advises physicians and parents of the possible increased risk of Reye syndrome associated with the use of salicylates for children with chickenpox and influenza-like illness' (3). (
  • It was the consensus of the scientific working group at the completion of the meeting that the new analysis supported the earlier evidence of an association between salicylates and Reye syndrome. (
  • National surveillance of Reye syndrome 1981: Update, Reye syndrome and salicylate usage. (
  • The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies around the world. (
  • [ 1 ] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and dramatic decrease in the incidence of Reye syndrome. (
  • [ 18 ] Some have postulated that salicylates stimulate the expression of inducible nitric oxide synthase (iNOS) because of the findings of iNOS stimulation in African children with fatal malaria, a disease that causes symptoms similar to those of Reye syndrome and is often treated with aspirin. (
  • 01). When the eight control subjects who took salicylate were compared with the patients, the patients still tended to take larger doses ( P = .08). (
  • Infusion of artificial cerebrospinal fluid (aCSF) or 10.0 μg doses of salicylate did not. (
  • Copper salicylate is a compound with formula Cu(C7H5O3). (
  • Recognition of the structural similarity between aspirin metabolites and enzyme substrates for the mitochondrial trifunctional enzyme important in beta-oxidation led to identification of the long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) component of the enzyme as the target of salicylate inhibition. (
  • [ 3 ] Absence of inhibition of beta-oxidation by salicylates in fibroblasts from patients with LCHAD deficiency substantiated the finding. (
  • The association of hemodialysis and survival in intubated salicylate-poisoned patients. (
  • 1.Cowan RA, Hartnell GG, Lowdell CP, Baird IM, Leak AM. Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. (
  • The purpose of this study is to determine whether a low salicylate diet will improve the quality of life of patients with Aspirin Exacerbated Respiratory Disease (AERD). (

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