Salicylates. Medical search

The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.

A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.

Salts and esters of gentisic acid.

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.

A group of 1,2-benzenediols that contain the general formula R-C6H5O2.

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.

A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.

A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.

A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.

A plant genus of the family ERICACEAE. The common name of "wintergreen" is also used for PYROLA and "snowberry" is also used for SYMPHORICARPOS.

Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.

A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.

Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.

A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)

Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.

Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.

Mechanical food dispensing machines.

The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.

The profession of writing. Also the identity of the writer as the creator of a literary production.

A publication issued at stated, more or less regular, intervals.

The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.

Places for cultivation and harvesting of fish, particularly in sea waters. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.

A plant genus of the family CORNACEAE. It is widely cultivated for the attractive flowers.

A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.

Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.

Perinatal nephropathies. (1/1030)

The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation. (+info)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)

Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate. (+info)

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated. (+info)

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin. (+info)

NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)

Two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10. While nahG resides in the same transcriptional unit as the meta-cleavage pathway genes, forming the naphthalene degradation lower pathway, nahW is situated outside but in close proximity to this transcriptional unit. The nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism. Both genes, nahG and nahW, have been cloned in Escherichia coli JM109. The overexpression of these genes yields peptides with apparent molecular masses of 46 kDa (NahG) and 43 kDa (NahW), respectively. Both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates, and chlorosalicylates. However, the relative rates by which the substituted analogs are transformed differ considerably. (+info)

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)

1. The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the activation of NF-kappaB elicited by tumour necrosis factor-alpha (TNF-alpha) on human umbilical vein endothelial cells (HUVEC) was tested. 2. The expression of the mRNA of vascular cell adhesion molecule-1 (VCAM-1) was studied as an example of a gene the expression of which is regulated by NF-kappaB. To extend these findings to other systems, the induction of nitric oxide synthase in rat adherent peritoneal macrophages was studied. 3. Both HTB and triflusal were more potent than aspirin or salicylate as inhibitors of the nuclear translocation of NF-kappaB. The calculation of the IC50 values showed approximately 2 mM for HTB, 4 mM for aspirin and >4 mM for salicylate. 4. Comparison of the potency of these compounds on VCAM-1 mRNA expression showed complete inhibition by both triflusal and HTB at a concentration of 4 mM whereas aspirin and salicylate produced only 36-43% inhibition at the same concentration. 5. Inhibition of NF-kappaB activation was also observed in rat peritoneal macrophages stimulated via their receptors for the Fc portion of the antibody molecule with IgG/ovalbumin immune complexes. This was accompanied by a dose-dependent inhibition of nitrite production by the L-arginine pathway via iNOS. IC50 values for this effect were 1.13+/-0.12 mM (triflusal), 1.84+/-0.34 (HTB), 6.08+/-1.53 mM (aspirin) and 9.16+/-1.9 mM (salicylate). 6. These data indicate that the incorporation of a 4-trifluoromethyl group to the salicylate molecule strongly enhances its inhibitory effect on NF-kappaB activation, VCAM-1 mRNA expression and iNOS induction, irrespective of the presence of the acetyl moiety involved in the inhibition of cyclo-oxygenase. (+info)

Reye's syndrome in the United States from 1981 through 1997. (7/1030)

BACKGROUND: Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella. Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome. METHODS: To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and risk factors for poor outcomes, we analyzed national surveillance data collected from December 1980 through November 1997. The surveillance system is based on voluntary reporting with the use of a standard case-report form. RESULTS: From December 1980 through November 1997 (surveillance years 1981 through 1997), 1207 cases of Reye's syndrome were reported in patients less than 18 years of age. Among those for whom data on race and sex were available, 93 percent were white and 52 percent were girls. The number of reported cases of Reye's syndrome declined sharply after the association of Reye's syndrome with aspirin was reported. After a peak of 555 cases in children reported in 1980, there have been no more than 36 cases per year since 1987. Antecedent illnesses were reported in 93 percent of the children, and detectable blood salicylate levels in 82 percent. The overall case fatality rate was 31 percent. The case fatality rate was highest in children under five years of age (relative risk, 1.8; 95 percent confidence interval, 1.5 to 2.1) and in those with a serum ammonia level above 45 microg per deciliter (26 micromol per liter) (relative risk, 3.4; 95 percent confidence interval, 1.9 to 6.2). CONCLUSIONS: Since 1980, when the association between Reye's syndrome and the use of aspirin during varicella or influenza-like illness was first reported, there has been a sharp decline in the number of infants and children reported to have Reye's syndrome. Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome. (+info)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)

OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels. (+info)

On the other hand, its not so long ago (Mid 1980s I think), that after centuries of using salicylates as fever remedies, the ...

https://www.thenakedscientists.com/forum/index.php?topic=81480.msg626055

Bismuth salicylate for the stomach, cough medicine, a light aperient calomel, and a strong one, unspecified; quinine sulphate, ...

http://www.ramc-ww1.com/chain_of_evacuation.php

Benzyl Salicylate**. *=certified organic. **=as a component part of pure essential oils. Free from synthetic fragrances, no ... Benzyl Salicylate**. *=certified organic. **=as a component part of pure essential oils. Free from synthetic fragrances, no ...

https://www.hemp-wholesale.com/page/shop/browse/category_id/bio-kosmetik

Octyl Salicylate (Sunscreen), Butylene Glycol (Humectant), Butyl Methoxydibenzoylmethane (Sunscreen), Ethyl Trisiloxane (Skin- ... Aqua (Solvent/Diluent), Ethylhexyl Methoxycinnamate (Sunscreen), Octyl Salicylate (Sunscreen), Butylene Glycol (Humectant), ... Benzyl Salicylate (Fragrance Ingredient), Potassium Sorbate (Preservative), Citric Acid (pH Adjuster), Ascorbic Acid ( ...

http://www.cudovita.si/tabla/index.php?showtopic=20105?forceDownload=1&_k=880ea6a14ea49e853634fbdc5015a024

Phenyl Salicylate - (Salol) (125G). *MERCURY STANDARD SOLUTION 1ML=0.1MG (100ML). *IODINE 0.0473 NORMAL (4L) ...

https://chem.sciencestuff.com/login.php

Phenyl Salicylate - (Salol) (125G). *MERCURY STANDARD SOLUTION 1ML=0.1MG (100ML). *IODINE 0.0473 NORMAL (4L) ...

https://chem.sciencestuff.com/index.php

Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. (medlineplus.gov)
Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. (medlineplus.gov)
Methyl salicylate can be poisonous in large amounts. (medlineplus.gov)
Other products may also contain methyl salicylate. (medlineplus.gov)
Below are symptoms of a methyl salicylate overdose in different parts of the body. (medlineplus.gov)
Methyl salicylate is the most poisonous form of the salicylate type of chemicals. (medlineplus.gov)
Greene T, Rogers S, Franzen A, Gentry R. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. (medscape.com)
Methyl salicylate exposure in toddlers. (medscape.com)
Its strong and pungent flavour comes from enhanced natural component, methyl salicylate , and such tea is highly reputed in some gourmet tea market worldwide. (thefreedictionary.com)
If you have an aching muscle or joint, you might rub on a topical rubefacient, products containing menthol or camphor (with or without methyl salicylate ) that provide a cooling sensation or a feeling of warmth. (thefreedictionary.com)
Aspirin is the most common salicylate, but there are others, including methyl salicylate, which is found as oil of wintergreen in some muscle ache creams. (labtestsonline.org.uk)
Methyl salicylate creams and topical forms of aspirin are absorbed into the body through the skin. (labtestsonline.org.uk)
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. (drugbank.ca)
For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. (drugbank.ca)
Molecular weight 152.15 Definition Methyl salicylate contains not less than 98 per cent. (inchem.org)
Methyl salicylate topical (for the skin) is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. (adventisthealthcare.com)
Ask a doctor or pharmacist about using methyl salicylate topical if you have any allergies (especially to aspirin or other salicylates), or if you have a serious medical condition. (adventisthealthcare.com)
It is not known whether methyl salicylate topical will harm an unborn baby. (adventisthealthcare.com)
It is not known whether methyl salicylate topical passes into breast milk or if it could harm a nursing baby. (adventisthealthcare.com)
Do not apply methyl salicylate topical to your breast area if you are breast-feeding a baby. (adventisthealthcare.com)
How should I use methyl salicylate topical? (adventisthealthcare.com)
Make sure your skin is clean and dry before you apply methyl salicylate topical. (adventisthealthcare.com)
To apply a methyl salicylate topical skin patch , remove the liner and apply the patch to your skin over the area of pain. (adventisthealthcare.com)
Methyl salicylate topical may be used up to 4 times daily or as directed on the medicine label. (adventisthealthcare.com)
Wash your hands with soap and water immediately after applying methyl salicylate topical or handling the skin patch. (adventisthealthcare.com)
Methyl salicylate can cause a cold or burning sensation wherever it is applied. (adventisthealthcare.com)
Avoid applying methyl salicylate right after bathing or shaving. (adventisthealthcare.com)
Since methyl salicylate topical is used as needed, it does not have a daily dosing schedule. (adventisthealthcare.com)
Call your doctor promptly if your symptoms do not improve after using methyl salicylate topical. (adventisthealthcare.com)
What should I avoid while using methyl salicylate topical? (adventisthealthcare.com)
Also known as 2-hydroxybenzoic acid, salicylic acid occurs naturally in the bark of the willow tree, Salix alba , and methyl salicylate is present in wintergreen leaves, Gaultheria procumbens , and in sweet birch bark, Betula lenta . (cosmeticsinfo.org)
Iodex with Methyl Salicylate , 1 oz. (baar.com)
Iodex with Methyl Salicylate relieves local congestion. (baar.com)
The Iodex with Methyl Salicylate has been wonderful for my wonky knee. (baar.com)
IODEX with methyl salicylate will relieve local congestion moderating the symptoms: local aches and pains, soreness and stiffness of muscles. (medshopexpress.com)
Many major brands of mouthwash contain essential oils and therefore salicylic acid, or it may list it as methyl salicylate, menthol, or other plant extracts. (cleure.com)
In 2007, a teen was reported as dead due to overdosing on methyl salicylate after rubbing her sore thigh muscle with a pain reducing cream, Bengay. (cleure.com)

M.J.H. Smith, A.W. Ford-Hutchinson and P.C. Elliott , Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate , J. Pharm. (springer.com)
Fourth, the data on the role of sodium bicarbonate in the management of salicylate poisoning will be provided. (thefreedictionary.com)
Sodium Salicylate has analgesic, anti-inflammatory and antipyretic action. (intekom.com)
The principal use of Sodium Salicylate is in the treatment of acute rheumatic fever. (intekom.com)
Sodium salicylate is contra-indicated in the presence of severe renal disease. (intekom.com)
Sodium Salicylate is a gastric irritant and sodium bicarbonate is often given with it to reduce this effect (however the bicarbonate also increases rate of excretion and this lowers the concentration of salicylate in the blood). (intekom.com)
Patients suffering from severe intoxication (a plasma-salicylate concentration above 500 mg/mL in adults or 300 mg/mL in children) should be given gastric lavage together with forced diuresis by I/V infusions of saline with sodium bicarbonate or of compound sodium lactate injection or dextrose solution. (intekom.com)
Infusion of sodium salicylate (50.0 or 100.0 μg/μl) into the ventral septal area (VSA) of the rat brain suppressed Prostaglandin-E 1 -induced hyperthermia. (springer.com)
These results are consistent with the notion that sodium salicylate infusions within the VSA enhance AVP action and thus bring about the attenuation of PGE-induced hyperthermia. (springer.com)
Alexander SJ, Cooper KE, Veale WL (1987) Blockade of prosta-glandin E 1 hyperthermia by sodium salicylate given into the ventral septal area of the rat brain. (springer.com)
Cranston WI, Rawlins MD (1972) Effects of intracerebral microinjection of sodium salicylate on temperature regulation in the rabbit. (springer.com)
Hori T, Nakashima T, Kiyohara T, Shibata M (1984) Effects of leukocytic pyrogen and sodium salicylate on hypothalamic neurons in vitro. (springer.com)
What Is the Chemical Formula for Sodium Salicylate? (reference.com)
All of the numbers in the chemical formula for sodium salicylate are subscript numbers in accordance with standard chemical formula notation. (reference.com)
Sodium salicylate is used as a pain reliever as well as to reduce or prevent fever, and it works by inhibiting the enzyme cyclooxygenase, also known as COX. (reference.com)
However, aspirin can cause gastrointestinal bleeding in susceptible individuals, so sodium salicylate is used as an alternative drug. (reference.com)
The effectiveness of sodium salicylate is less than that of aspirin in equal doses. (reference.com)
What Are the Medical Uses of Sodium Salicylate? (wisegeek.com)
Sodium salicylate has been used for medical purposes for hundreds of years. (wisegeek.com)
Sodium salicylate is one of the oldest fever reducing NSAIDs available. (wisegeek.com)
When sodium salicylate is used as a nonsteroidal anti-inflammatory drug, it works to reduce pain and inflammation in the body. (wisegeek.com)
People who are sensitive to aspirin may be directed to take sodium salicylate. (wisegeek.com)
Since sodium salicylate may be used as an analgesic, it is often recommended for people with body, muscle, or joint pain. (wisegeek.com)
Both homeopathic medicine practitioners and scientific studies have indicated that sodium salicylate may be helpful for people affected by rheumatism or rheumatoid arthritis . (wisegeek.com)
Sodium salicylate can be used to treat dandruff. (wisegeek.com)
As a result, people affected with a wide variety of fungal issues may use sodium salicylate. (wisegeek.com)
Sodium salicylate may be helpful for people with rheumatoid arthritis. (wisegeek.com)
Because side effects, such as gastrointestinal irritation, are possible, a medical provider should be consulted before using sodium salicylate. (wisegeek.com)
Sodium salicylate, an anti-inflammatory drug, may benefit people who are afflicted with joint and muscle pain. (wisegeek.com)
Regular use of large amounts of sodium salicylate (as for arthritis) can add a large amount of sodium to your diet. (mayoclinic.org)
Sodium salicylate contains 46 mg of sodium in each 325-mg tablet and 92 mg of sodium in each 650-mg tablet. (mayoclinic.org)
Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate may also be used for purposes not listed in this medication guide. (cigna.com)
You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, phenyl salicylate, or sodium biphosphate. (cigna.com)
Not all salicylates have the word salicylate in their name--though some do, like magnesium salicylate and sodium salicylate. (lovetoknow.com)
High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. (frontiersin.org)
Aspirin, with sodium salicylate as an active ingredient, is one of the most widely used analgesic, anti-inflammatory, and antipyretic drugs ( 1 ). (frontiersin.org)
Sodium salicylate at a high dose (1-10 mM) can induce a moderate, reversible cochlear hearing loss (~20-40 dB threshold elevation), tinnitus, and suppression of otoacoustic emissions (OAEs) ( 2 , 3 ). (frontiersin.org)
Methenamine and sodium salicylate is a combination medicine that is used to relieve symptoms of bladder infection or irritation, such as painful or burning urination, or feeling an urgent or more frequent need to urinate. (everydayhealth.com)
You should not use this medicine if you are allergic to methenamine, sodium salicylate, or aspirin. (everydayhealth.com)
Ask a doctor before using methenamine and sodium salicylate to treat painful or frequent urination if you've never had these symptoms before. (everydayhealth.com)
Do not give methenamine and sodium salicylate to a child younger than 12 without medical advice. (everydayhealth.com)
Can I take Methenamine And Sodium Salicylate(Oral) if I'm pregnant or breastfeeding? (everydayhealth.com)
They may contain ingredients similar to methenamine and sodium salicylate (such as aspirin, ibuprofen, ketoprofen, or naproxen). (everydayhealth.com)
Use Methenamine And Sodium Salicylate(Oral) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)

Polarised light micrograph of potassium salicylate, C7H5NaO3, (potassium 2-hydroxybenzoate), an analgesic and antipyretic drug. (sciencephoto.com)

Some medical conditions may interact with acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine. (drugs.com)
Ask your health care provider if acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine may interact with other medicines that you take. (drugs.com)
What is the most important information I should know about magnesium salicylate? (cigna.com)
An overdose of magnesium salicylate can be fatal. (cigna.com)
Magnesium salicylate may cause stomach or intestinal bleeding, which can be fatal. (cigna.com)
These conditions can occur without warning while you are using magnesium salicylate, especially in older adults. (cigna.com)
What is magnesium salicylate? (cigna.com)
Magnesium salicylate is a salicylate (sa-LIS-il-ate). (cigna.com)
Magnesium salicylate may also be used for purposes not listed in this medication guide. (cigna.com)
What should I discuss with my healthcare provider before taking magnesium salicylate? (cigna.com)
Magnesium salicylate can cause Reye's syndrome, a serious and sometimes fatal condition in children. (cigna.com)
Magnesium salicylate is not approved for use by anyone younger than 12 years old. (cigna.com)
Taking magnesium salicylate during late pregnancy may cause bleeding in the mother or the baby during delivery. (cigna.com)
Magnesium salicylate can pass into breast milk and may harm a nursing baby. (cigna.com)
How should I take magnesium salicylate? (cigna.com)
Take with food if magnesium salicylate upsets your stomach. (cigna.com)
If you need surgery, tell the surgeon ahead of time that you are using magnesium salicylate. (cigna.com)
Since magnesium salicylate is used when needed, you may not be on a dosing schedule. (cigna.com)
What should I avoid while taking magnesium salicylate? (cigna.com)
Avoid drinking alcohol while you are taking magnesium salicylate. (cigna.com)
Many medicines available over the counter contain aspirin or other medicines similar to magnesium salicylate. (cigna.com)
What are the possible side effects of magnesium salicylate? (cigna.com)
There are no evaluations for Magnesium Salicylate. (patientslikeme.com)
Magnesium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). (rexhealth.com)
You should not take this medication if you are allergic to acetaminophen (Tylenol), magnesium salicylate (Nuprin), pamabrom, aspirin or other NSAIDs. (rexhealth.com)
Magnesium salicylate may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. (rexhealth.com)
Do not take acetaminophen, magnesium salicylate, and pamabrom without telling your doctor if you are pregnant or plan to become pregnant during treatment. (rexhealth.com)
Magnesium salicylate is an aspirin-like drug used to relieve mild to moderate pain. (sharecare.com)
an allergy to salicylates (such as aspirin, choline magnesium trisalicylate, magnesium salicylate). (cigna.com)
What are the risks of taking magnesium salicylate? (sharecare.com)
Risks of taking magnesium salicylate include: harm to your fetus if you are pregnant, possible harm to your nursing baby if you are breastfeeding, interference with blood clotting and low blood sugar if you are diabetic or receiving hemodialysis. (sharecare.com)
It is possible that use of magnesium salicylate can impede blood clotting or lead to unusual bleeding. (sharecare.com)

Menthol, mint, benzoates, and beta-hydroxy acid are a few of the different names of salicylate compounds. (lovetoknow.com)

Lewis TV, Badillo R, Schaeffer S, Hagemann TM, McGoodwin L. Salicylate toxicity associated with administration of Percy medicine in an infant. (medscape.com)
Salicylate toxicity model of tinnitus. (medscape.com)
Delayed Salicylate Toxicity in a 17-Year-Old Girl With Initially Undetectable Salicylate Concentration 3.9 Hours After Ingestion. (medscape.com)
Salicylate toxicity may result from acute or chronic ingestion of acetylsalicylic acid (aspirin is a generic name in the United States but a brand name in the rest of the world). (unboundmedicine.com)
If too much salicylate is ingested at one time ( acute toxicity) or too much is taken over a period of time ( chronic toxicity), and/or if the body's ability to remove the salicylates is reduced, then signs and symptoms associated with toxicity will begin to emerge. (labtestsonline.org.uk)
The symptoms of acute salicylate poisoning may be minimal initially with severe toxicity not evident until 6-12 hours. (rch.org.au)
No convincing data support the use of repeated doses of activated charcoal in salicylate toxicity. (medscape.com)
Following its review the MHRA concluded that the symptoms described in this case could not be considered to be Reye's syndrome and were more likely due to salicylate toxicity from overuse of the product. (medsafe.govt.nz)

If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (healthbanks.com)
Hyoscyamine, methenamine, methylene blue, and phenyl salicylate is a combination medicine used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. (healthbanks.com)
Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (healthbanks.com)
If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate. (healthbanks.com)
What are the possible side effects of hyoscyamine, methenamine, methylene blue, and phenyl salicylate? (healthbanks.com)

Absorption of salicylate powders versus tablets following overdose: a poison center observational study. (medscape.com)
Salicylate testing measures the concentration in the blood to detect and/or monitor an overdose (salicylate poisoning). (labtestsonline.org.uk)
Salicylate sensitivity varies - some people improve just by cutting down, some people have to avoid high salicylate foods, and some people are only affected by an overdose of salicylate medications. (fedup.com.au)

Reye's syndrome and salicylate use. (cdc.gov)
05). It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome. (aappublications.org)
Aspirin (and salicylates) has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chicken pox and influenza. (intekom.com)
Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition in children. (cigna.com)
Medsafe's review found no evidence linking Reye's syndrome to the use of topical oral choline salicylate containing products. (medsafe.govt.nz)
This is very important because salicylates may cause a serious illness called Reye's syndrome in children and teenagers with fever caused by a virus infection, especially flu or chickenpox. (mayoclinic.org)

In New Zealand three topical products for oral use contain choline salicylate: Bonjela Teething Gel, Bonjela Mouth Ulcer Gel and Ora-sed gel. (medsafe.govt.nz)
Medsafe's advice follows a review of the recent decision by the United Kingdom Medicines and Healthcare products Regulatory Agency (MHRA) to contraindicate the use of all topical oral choline salicylate gels in children under 16 years of age. (medsafe.govt.nz)

I have celiac disease, a salicylate intolerance AND milk allergy. (medhelp.org)
While salicylate sensitivity, also known as salicylate intolerance, is not as common as gluten or lactose intolerance, it's a real issue for some people. (healthline.com)
Compared to foods, medications like aspirin contain high amounts of salicylates, which is why salicylate intolerance is most commonly linked to medications. (healthline.com)
The buildup of leukotrienes in the body leads to symptoms related to salicylate intolerance. (healthline.com)
Although the percentage of people who have a salicylate intolerance is unknown, it is more common in adults who suffer from asthma ( 5 ). (healthline.com)
Summary People with salicylate intolerance are unable to consume even small amounts of these chemicals without experiencing negative side effects. (healthline.com)
In my experience, most people with salicylate intolerance have no idea what could be affecting them. (fedup.com.au)
I was told in my 30s that I had genetic salicylate intolerance but given no more info. (fedup.com.au)
About 10 years ago I found the Australian salicylate list (I'm in the U.S.) I'm now 71 yrs and my gut intolerance is getting worse. (fedup.com.au)
You may not even be aware that you have salicylate sensitivity, salicylate intolerance or salicylate allergy. (cleure.com)

Salicylates are compounds found in foods, medications and other products that can cause adverse reactions in those who are intolerant. (healthline.com)
Salicylates are just one group of the hundreds of compounds in foods that can have varying effects on us, depending on how much we eat and how sensitive we are. (fedup.com.au)
Experiments using radiolabeled chloramphenicol and salicylate demonstrated active efflux of both compounds in the presence of the gene cluster. (jci.org)
Salicylate is clearly separated from the other two compounds, which move together with only partial resolution (Fig. 1). (nature.com)

Remove the skin of chicken because it is high in amines and avoid aged meat because of its high salicylate, amine and glutamate content. (livestrong.com)
Patients will avoid foods from the 'high salicylate' group completely. (clinicaltrials.gov)

Salicylates are chemicals found in plants and are a major ingredient in aspirin and other pain-relieving medications . (webmd.com)
Because the use of salicylates such as aspirin for children with influenza and chickenpox has been associated with Reye syndrome, the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. (cdc.gov)
advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox. (cdc.gov)
This fact became evident when several guardians of our patients came in within a few days of each other in late November to early December unaware of the dangers of giving their children aspirin and other salicylate medications. (thefreedictionary.com)
Salicylates are chemicals found naturally in certain foods and also synthetically produced for use in medications and other products. (healthline.com)
Salicylates are a group of drugs, including aspirin, available as both prescription and non-prescription (over-the-counter) medications. (labtestsonline.org.uk)
Salicylates are also found in medications, fragrances, industrial chemicals, plastics and some pesticides, and can cause adverse effects when inhaled as well as eaten. (fedup.com.au)
Salicylate levels are also measurable in individuals not taking aspirin or salicylate medications ( 9 , 11-14 ). (aacrjournals.org)

Phenyl salicylate is a mild pain reliever. (cigna.com)

This article explains the causes and symptoms of salicylate sensitivity, including which foods to avoid. (healthline.com)
What are some of the symptoms of salicylate sensitivity? (fedup.com.au)

Methods: A tinnitus model was established in rats through intraperitoneal injection of salicylate (SA). (thefreedictionary.com)
Salicylate, the active component of aspirin, is known to induce tinnitus. (jneurosci.org)
However, the site and the mechanism of generation of tinnitus induced by salicylate remains unclear. (jneurosci.org)
Mefenamate in place of salicylate also increased the number of false positive responses, suggesting that salicylate-induced tinnitus is related to an inhibition of cyclooxygenase. (jneurosci.org)
Application of NMDA antagonists into the perilymphatic fluids of the cochlea blocked the increase in pole-jumping behavior induced by salicylate, suggesting that salicylate induces tinnitus through activation of cochlear NMDA receptors. (jneurosci.org)
Has anyone else experienced pulsatile tinnitus from salicylates? (fedup.com.au)

You should not use this medicine if you are allergic to salicylates (such as aspirin) or other nonsteroidal anti-inflammatory drugs (NSAIDs). (cigna.com)
The active and major component in aspirin/NSAIDs is salicylate, which is also found naturally in some foods. (clinicaltrials.gov)

Diet is known to be a source of salicylates, including fruits, vegetables, and meat. (aacrjournals.org)
especially, if the source of salicylates is in a concentrated form like aspirin. (lovetoknow.com)

However, the association between serum salicylate level and recurrence of adenoma in nonusers of aspirin has not been studied. (aacrjournals.org)
We measured serum salicylate levels in participants in a randomized controlled trial with calcium supplementation for the prevention of colorectal adenomas. (aacrjournals.org)
We did not find an association with recurrence of adenomas or advanced adenomas with serum salicylate levels at year 1 among nonusers of aspirin. (aacrjournals.org)
Among nonusers of ASA, serum salicylate levels are not associated with risk of recurrence of adenomas. (aacrjournals.org)
Serum salicylate levels can be detected in individuals not taking aspirin, but the levels may be too low to confer protection from risk of recurrent adenomas. (aacrjournals.org)
ASA), is readily detected in serum and urine of humans and is a measure of salicylates, whether from ASA use or from diet and endogenous sources. (aacrjournals.org)
These include certain colonic bacteria species that may have the ability to synthesize SA, and synthesis of SA via metabolism of hippuric acid, a metabolite of benzoic acid demonstrated to be formed endogenously in man ( 18 ) The associations of serum salicylate levels, in particular among nonusers of aspirin, in reducing risk of colorectal adenoma are not known. (aacrjournals.org)
The aim of our study was to determine whether serum salicylate levels among individuals with history of prior adenoma are associated with risk of colorectal adenoma in individuals not taking aspirin. (aacrjournals.org)

These studies conducted by state health departments suggest an association between prior ingestion of aspirin and other salicylates and Reye syndrome. (cdc.gov)
Aspirin and other salicylates are most often used to reduce pain , fever , and inflammation. (medlineplus.gov)
But aspirin and other salicylates are usually safe and effective for adults when taken at the proper dose. (medlineplus.gov)

Vantelin's odorless liquid is the company's "halo product," utilizing 10% trolamine salicylate to relieve aches and pains. (thefreedictionary.com)

While TEA-Salicylate is also an FDA-approved over-the-counter active sunscreen ingredient, its use today is very limited or non-existent (see Safety Information tab). (cosmeticsinfo.org)
The U.S. Food and Drug Administration (FDA) approved TEA-salicylate (trolamine salicylate) for use as an active sunscreen ingredient in over-the-counter (OTC) sunscreen drug products at concentrations up to 12 percent. (cosmeticsinfo.org)
Accordingly, FDA proposed trolamine salicylate be classified as a Category II (i.e., not GRASE) sunscreen active ingredient, due to safety concerns. (cosmeticsinfo.org)
If this proposed rule becomes final, sunscreen products in the marketplace would no longer be allowed to contain trolamine salicylate as an active ingredient. (cosmeticsinfo.org)
The safety of salicylic acid and its salts and esters, including TEA-salicylate, has been assessed by the Cosmetic Ingredient Review ( CIR ) Expert Panel on several occasions. (cosmeticsinfo.org)
However, per CIR standard procedure, the use of TEA-salicylate as a sunscreen ingredient was not included in the review (CIR does not review the active ingredients in over-the-counter drugs). (cosmeticsinfo.org)
As before, the review of TEA-salicylate did not include its use as an active sunscreen ingredient. (cosmeticsinfo.org)
TEA-salicylate is not approved as an active sunscreen ingredient in the EU. (cosmeticsinfo.org)
FDA was concerned that use of trolamine salicylate as an active ingredient in sunscreens could cause serious detrimental health effects due to the anti-coagulation effects of salicylic acid. (cosmeticsinfo.org)

People with a low tolerance may have an allergic reaction if they get more than a small amount of salicylate. (webmd.com)
If you're allergic to salicylates, you'll need to avoid items that have them. (webmd.com)
If prone to allergic reaction from aspirin or salicylates, consult a doctor before use. (nih.gov)
I found a table with a list of salicylates and all the items I had previously been told I was "allergic to" were listed as high in salicylates. (lovetoknow.com)

Kirshenbaum LA, Mathews SC, Sitar DS, Tenenbein M. Does multiple-dose charcoal therapy enhance salicylate excretion? (medscape.com)
4.5 mEq/L). Urinary alkalization promotes the excretion of salicylate. (medscape.com)

Research shows that about 20% of adults with asthma 1 , 60% with of people with food-induced itchy rashes, headaches or migraines, 70% of people with irritable bowel symptoms 2 and 75% of children with behaviour problems 3 may be sensitive to salicylates. (fedup.com.au)
If a person is sensitive to salicylates, what kind of symptoms can they expect? (lovetoknow.com)

Physostigmine Salicylate Injection is an antidote used to reverse the effect of drugs that cause anticholinergic syndrome. (rxlist.com)
Our Physostigmine Salicylate Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)

Rauschka H, Aboul-Enein F, Bauer J, Nobis H, Lassmann H, Schmidbauer M. Acute cerebral white matter damage in lethal salicylate intoxication. (medscape.com)

Between our list of salicylates to avoid on Stage One, and the extended list included in the Handbook, you will find the most complete list available of salicylate-containing items, plus benzoate information since many salicylate-sensitive people are also sensitive to benzoates. (feingold.org)

The ability to remove salicylates efficiently is affected by the body's blood and urine pH (acidity/alkalinity) and by kidney function. (labtestsonline.org.uk)
Alkalization of the urine enhances elimination of salicylates through ion trapping in the renal tubules. (medscape.com)
Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. (nih.gov)
The salicylate content of blood and urine was shown to increase following consumption of a variety of meals, both vegetarian and meat-based, ranging from southern Indian dishes to European ones ( 15, 16 ). (aacrjournals.org)

Natural flavoring" may contain salicylate. (feingold.org)

Salicylates, by inhibiting the synthesis of prostaglandins that occur in inflamed tissues, prevent the sensitization of the pain receptors to mechanical stimulation or to chemicals, such as bradykinin, that appear to mediate pain response. (intekom.com)
Salicylates are a group of chemicals derived from salicylic acid. (healthline.com)
However, those with a sensitivity to salicylates may experience side effects when they consume a food or use a product that contains even small amounts of these chemicals. (healthline.com)
Salicylates are chemicals that occur naturally in many plants - they're a kind of natural pesticide - to protect the plants against insects and diseases. (fedup.com.au)
Various sunscreen ingredients including octyl salicylate and oxybezone increases the asborption of other potentially harmful chemicals. (greenmedinfo.com)
Salicylates are chemicals found naturally in some plants, stored in the bark, leaves, roots, skin and seeds, where they protect the plants against insect damage and disease. (feingold.org)
Salicylates are natural chemicals produced by plants. (lovetoknow.com)

What is the role of salicylates in the etiology of Reye syndrome? (medscape.com)

This test measures the amount of salicylates in the blood. (medlineplus.gov)
The amount of salicylates that trigger a reaction can differ depending on the individual's ability to break them down. (healthline.com)

When these two medicines are taken together, the toxic effects of salicylates (e.g. aspirin) may increase. (webmd.com)
Children who do not have a virus infection may also be more sensitive to the effects of salicylates, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. (mayoclinic.org)
Elderly people are especially sensitive to the effects of salicylates. (mayoclinic.org)

People with a sensitivity to salicylates or any other substance can experience the exact same symptoms as a person with an allergy. (lovetoknow.com)

The 2019 proposed rule concluded the risks associated with use of trolamine salicylate in sunscreen products outweighs its benefits. (cosmeticsinfo.org)

Trolamine salicylate (Aspercreme, Aspergel) is an organic compound which is the salt formed between triethanolamine and salicylic acid . (wikipedia.org)
The US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the Daily Med database that contain trolamine salicylate. (wikipedia.org)
[1] Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue. (wikipedia.org)
[2] However, one study reported that trolamine salicylate does penetrate into, and persist within, underlying muscle tissue. (wikipedia.org)
The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to induce muscle soreness. (wikipedia.org)
The experimenters observed that those using the trolamine salicylate product exercised longer before reporting the onset of soreness, reported less intense soreness, and reported that their soreness did not last as long as the people who used the placebo. (wikipedia.org)
All of the trolamine salicylate-containing products listed in the two cited references are 10% solutions. (wikipedia.org)
FDA's Preliminary Regulatory Impact Analysis reviewed more than 700 sunscreen brands sold in the United States, and indicated trolamine salicylate is no longer used in products marketed in the U.S. (cosmeticsinfo.org)
Based on an evaluation of all available scientific data, CIR concluded salicylic acid and 17 salicylate ingredients (including TEA-salicylate/ trolamine salicylate) are safe in cosmetics in the present practices of use and concentration, when formulated to be non-irritating and non-sensitizing to skin, which may be based on a quantitative risk assessment ( QRA ). (cosmeticsinfo.org)
Trolamine salicylate is comprised of trolamine and salicylic acid. (cosmeticsinfo.org)
FDA located two case reports of serious coagulation-related adverse events associated with liberal dermal application of trolamine salicylate. (cosmeticsinfo.org)

Morpholine salicylate is a nonsteroidal anti-inflammatory drug. (wikipedia.org)
Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. (harvard.edu)

What made you want to look up amyl salicylate ? (merriam-webster.com)

2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. (ewg.org)
Applied topically, benzyl salicylate can cause negative reactions, even in small amounts. (paulaschoice.com)

In moderate to severe salicylate poisoning, consider decontamination (activated charcoal) and the early enhancement of elimination (urinary alkalisation with or without haemodialysis). (rch.org.au)
Haemodialysis should be considered early in moderate to severe salicylate poisoning as urinary alkalisation can be difficult to achieve and may not be effective. (rch.org.au)
If, however, you already have a diagnosis of severe salicylate sensitivity, or you have tried the Stage One diet with only partial improvement, it may be worth your while to try avoiding also those items listed on pages 51 through 57 in the Handbook. (feingold.org)

Salicylic acid and its salts (including TEA-salicylate) are listed in the Cosmetics Directive of the European Union and may be used as preservatives in cosmetics and personal care products at a maximum concentration of 0.5 percent (see Annex V, entry 3 ). (cosmeticsinfo.org)
TEA-Salicylate may be used in rinse-off cosmetic products without concentration restrictions and in leave-on products at a maximum concentration of 2.5 percent (see Annex III, entry 62 ). (cosmeticsinfo.org)
These results suggest that salicylate is a natural substrate for the efflux pump in B. cenocepacia and imply that the environment of low iron concentration in the cystic fibrosis lung can induce efflux-mediated resistance, even in the absence of antibiotic selective pressure. (jci.org)
A more recent study found that at moderate concentrations (0.1-1 mM), salicylate also causes a concentration-dependent reversible reduction of a voltage-gated potassium channel, which is encoded by KCNQ4 gene of OHCs ( 10 ). (frontiersin.org)

Hamdan JA, Manasra K, Ahmed M. Salicylate-induced hepatitis in rheumatic fever. (medscape.com)
Over-the counter salicylates are used as needed or regularly to reduce pain, fever, and inflammation. (labtestsonline.org.uk)
Do not give aspirin or other salicylates to a child or a teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. (mayoclinic.org)

The best known salicylate is aspirin (acetylsalicylic acid), which was originally extracted from willow bark. (fedup.com.au)

The Surgeon General notes that the FDA will notify health professionals through its Drug Bulletin, will develop lay-language information for widespread distribution, and will take the steps necessary to establish new labeling requirements for drugs containing salicylates. (cdc.gov)
Other drugs may interact with physostigmine salicylate. (rxlist.com)

We discuss our own experiences with children who were referred for care to the allergy clinics of three public hospitals, and who had previously used these diets, and review the evidence for using low salicylate diets in treating a variety of disease indications. (mja.com.au)
We sought to identify the indications for which salicylate elimination is prescribed in Sydney by conducting a retrospective case note review of children attending the allergy clinics of the two main children's hospitals, Sydney Children's Hospital and the Children's Hospital at Westmead, as well as a major regional allergy clinic at Campbelltown Hospital, between 1 January 2003 and 31 December 2011. (mja.com.au)
What is the evidence supporting the role of low salicylate diets for these indications? (mja.com.au)

E. Quilley and M.J.H. Smith , The Application of Paper Partition Chromatography to the Study of the Metabolism of Salicylate in the Rat , J. Pharm. (springer.com)
The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. (nih.gov)
The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. (nih.gov)
One physiological basis of salicylate ototoxicity is likely to originate from altered arachidonic acid metabolism. (jneurosci.org)
Proceedings: Kinetics of salicylate metabolism. (bmj.com)

Salicylate sensitivity can cause varied symptoms that mimic allergies and illness. (healthline.com)
If your frequent use skin care or personal care products contain any synthetic or natural form of salicylic acid, over time, you could develop salicylate sensitivity and eventually a variety of symptoms associated with salicylic acid allergies. (cleure.com)

Biological Data Biochemical aspects The orally administered ester undergoes very rapid and nearly complete hydrolysis in rats and dogs, salicylate being the only significant finding in the blood of rats 20 minutes after an intragastric dose, and in dogs within an hour of oral dosing. (inchem.org)
of salicylate as the ester being present in plasma after 90 minutes. (inchem.org)
The ester is potentially the most toxic salicylate for infants and children, as 4 ml can be fatal (Davison et al. (inchem.org)

Salicylic acid inhibits prostaglandin biosynthesis in vivo as the salicylate ion itself and there is no formation of a subsequent 'active' metabolite. (springer.com)
One study demonstrated that salicylates decrease beta-oxidation of the long-chain fatty acid palmitate by cultured fibroblasts from children who recovered from Reye syndrome as compared with control subjects. (medscape.com)
After oral forms of salicylates are ingested, they are converted to salicylic acid, absorbed in the stomach and small intestine and transferred into the blood stream. (labtestsonline.org.uk)
The salts, esters of salicylic acids, or salicylate esters of an organic acid. (curehunter.com)
The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives. (nih.gov)

If you regularly take a prescription salicylate, your doctor may want to collect blood just prior to your next dose (trough level). (labtestsonline.org.uk)
The dose of your salicylate medicine may need adjusting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. (webmd.com)

The association of salicylates with Reye syndrome is based upon evidence from epidemiologic studies that are sufficiently strong to justify this warning to parents and health care personnel. (cdc.gov)
CDC, on the basis of its review of the available data and the recommendations of an advisory panel on February 12, 1982, stated that 'until definitive information is available, CDC advises physicians and parents of the possible increased risk of Reye syndrome associated with the use of salicylates for children with chickenpox and influenza-like illness' (3). (cdc.gov)
It was the consensus of the scientific working group at the completion of the meeting that the new analysis supported the earlier evidence of an association between salicylates and Reye syndrome. (cdc.gov)
National surveillance of Reye syndrome 1981: Update, Reye syndrome and salicylate usage. (cdc.gov)
The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies around the world. (medscape.com)
[ 1 ] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and dramatic decrease in the incidence of Reye syndrome. (medscape.com)
[ 18 ] Some have postulated that salicylates stimulate the expression of inducible nitric oxide synthase (iNOS) because of the findings of iNOS stimulation in African children with fatal malaria, a disease that causes symptoms similar to those of Reye syndrome and is often treated with aspirin. (medscape.com)

01). When the eight control subjects who took salicylate were compared with the patients, the patients still tended to take larger doses ( P = .08). (aappublications.org)
Infusion of artificial cerebrospinal fluid (aCSF) or 10.0 μg doses of salicylate did not. (springer.com)

Copper salicylate is a compound with formula Cu(C7H5O3). (wikipedia.org)

Recognition of the structural similarity between aspirin metabolites and enzyme substrates for the mitochondrial trifunctional enzyme important in beta-oxidation led to identification of the long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) component of the enzyme as the target of salicylate inhibition. (medscape.com)
[ 3 ] Absence of inhibition of beta-oxidation by salicylates in fibroblasts from patients with LCHAD deficiency substantiated the finding. (medscape.com)

The association of hemodialysis and survival in intubated salicylate-poisoned patients. (medscape.com)
1.Cowan RA, Hartnell GG, Lowdell CP, Baird IM, Leak AM. Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. (webmd.com)
The purpose of this study is to determine whether a low salicylate diet will improve the quality of life of patients with Aspirin Exacerbated Respiratory Disease (AERD). (clinicaltrials.gov)

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Perinatal nephropathies. (1/1030)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)

NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)

Reye's syndrome in the United States from 1981 through 1997. (7/1030)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)

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Perinatal nephropathies. (1/1030)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (2/1030)

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. (3/1030)

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus. (4/1030)

NahW, a novel, inducible salicylate hydroxylase involved in mineralization of naphthalene by Pseudomonas stutzeri AN10. (5/1030)

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. (6/1030)

Reye's syndrome in the United States from 1981 through 1997. (7/1030)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/1030)

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