Amides of salicylic acid.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
The relative amounts of various components in the body, such as percentage of body fat.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Substances that reduce the growth or reproduction of BACTERIA.
The sudden sensation of being cold. It may be accompanied by SHIVERING.
Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.
An order of flagellate protozoa. Characteristics include the presence of one or two flagella arising from a depression in the cell body and a single mitochondrion that extends the length of the body.
Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
A subclass of segmented worms comprising the tapeworms.
Infections with true tapeworms of the helminth subclass CESTODA.
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.
A combination of the debris index and the dental calculus index to determine the status of oral hygiene.
A tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries.
Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)
A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)
Plugs or cylinders made of cotton, sponge, or other absorbent material. They are used in surgery to absorb fluids such as blood or drainage.
Personal care items used during MENSTRUATION.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
A genus of bacteria found in the human genital and urinary tract. It is considered to be a major cause of bacterial vaginosis (VAGINOSIS, BACTERIAL).
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A widely used industrial solvent.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions.
An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
Antibacterial, potentially toxic, used to treat certain skin diseases.
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.
A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
A species of STIGMATELLA usually isolated from rotting wood. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
Organic compounds containing the radical -CSNH2.
Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.
An iron-binding cyclic trimer of 2,3-dihydroxy-N-benzoyl-L-serine. It is produced by E COLI and other enteric bacteria.
The fern plant family of the order Polypodiales, class Filicopsida, division Pteridophyta, subkingdom Tracheobionta.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Measurement of striatal D2 dopamine receptor density and affinity with [11C]-raclopride in vivo: a test-retest analysis. (1/276)

Subacute and long-term stability of measurements of D2 dopamine receptor density (Bmax), affinity (Kd) was studied with positron emission tomography in eight healthy male volunteers. [11C]-Raclopride and the transient equilibrium method were used to measure D2 receptor characteristics. The interval between measurements (scan pairs) was 3 to 7 weeks (subacute) for four subjects and 6 to 11 months (long-term) for four subjects. A test-retest analysis of quantitative measurements of D2 receptor Bmax and Kd was compared with that done on binding potential (BP, Bmax/Kd) measures. In addition, the effect of error in defining the transient equilibrium time (tmax) in the parameter estimation procedure was explored with simulations. The subacute test-retest indicates good reproducibility of D2 receptor density, affinity, and BP ratio measurements with intraclass correlation coefficients of 0.90, 0.96, and 0.86, respectively. The variability of the measurements after 6 to 11 months was slightly higher than that seen in a subacute testing for Kd and more clearly so for binding potential and Bmax. The absolute variability in Bmax (14.5%) measurements was consistently higher than that of Kd (8.4%) or BP (7.9%) both in subacute and long-term measurements. Simulations indicated that the Bmax and Kd estimation procedure is more sensitive to error in the tmax than that for the BP. The results indicate a good overall stability of the equilibrium method with [11C]raclopride for measuring dopamine D2 receptor binding characteristics in the striatum. The BP approach is more stable than Kd and especially Bmax measurements. Error in defining the tmax in particular in the low specific radioactivity scan may be one source of greater variability in Bmax versus BP. However, a higher intraindividual variability in measurements of the D2 receptor Bmax also may include a component of continuous regulation of this parameter over time. These methodologic aspects should be considered in the design and interpretation of longitudinal studies on D2 dopamine receptor characteristics with [11C]-raclopride.  (+info)

Alternative oxidase inhibitors potentiate the activity of atovaquone against Plasmodium falciparum. (2/276)

Recent evidence suggests that the malaria parasite Plasmodium falciparum utilizes a branched respiratory pathway including both a cytochrome chain and an alternative oxidase. This branched respiratory pathway model has been used as a basis for examining the mechanism of action of two antimalarial agents, atovaquone and proguanil. In polarographic assays, atovaquone immediately reduced the parasite oxygen consumption rate in a concentration-dependent manner. This is consistent with its previously described role as an inhibitor of the cytochrome bc1 complex. Atovaquone maximally inhibited the rate of P. falciparum oxygen consumption by 73% +/- 10%. At all atovaquone concentrations tested, the addition of the alternative oxidase inhibitor, salicylhydroxamic acid, resulted in a further decrease in the rate of parasite oxygen consumption. At the highest concentrations of atovaquone tested, the activities of salicylhydroxamic acid and atovaquone appear to overlap, suggesting that at these concentrations, atovaquone partially inhibits the alternative oxidase as well as the cytochrome chain. Drug interaction studies with atovaquone and salicylhydroxamic acid indicate atovaquone's activity against P. falciparum in vitro is potentiated by this alternative oxidase inhibitor, with a sum fractional inhibitory concentration of 0.6. Propyl gallate, another alternative oxidase inhibitor, also potentiated atovaquone's activity, with a sum fractional inhibitory concentration of 0.7. Proguanil, which potentiates atovaquone activity in vitro and in vivo, had a small effect on parasite oxygen consumption in polarographic assays when used alone or in the presence of atovaquone or salicylhydroxamic acid. This suggests that proguanil does not potentiate atovaquone by direct inhibition of either branch of the parasite respiratory chain.  (+info)

Effects of atypical antipsychotic drug treatment on amphetamine-induced striatal dopamine release in patients with psychotic disorders. (3/276)

Clozapine, risperidone, and other new "atypical" antipsychotic agents are distinguished from traditional neuroleptic drugs by having clinical efficacy with either no or low levels of extrapyramidal symptoms (EPS). Preclinical models have focused on striatal dopamine systems to account for their atypical profile. In this study, we examined the effects of clozapine and risperidone on amphetamine-induced striatal dopamine release in patients with psychotic disorders. A novel 11C-raclopride/PET paradigm was used to derive estimates of amphetamine-induced changes in striatal synaptic dopamine concentrations and patients were scanned while antipsychotic drug-free and during chronic treatment with either clozapine or risperidone. We found that amphetamine produced significant reductions in striatal 11C-raclopride binding during the drug-free and antipsychotic drug treatment phases of the study which reflects enhanced dopamine release in both conditions. There were no significant differences in % 11C-raclopride changes between the two conditions indicating that these atypical agents do not effect amphetamine-related striatal dopamine release. The implications for these data for antipsychotic drug action are discussed.  (+info)

5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man--a PET study with [11C]raclopride. (4/276)

The modulating effects of serotonin on dopamine neurotransmission are not well understood, particularly in acute psychotic states. Positron emission tomography was used to examine the effect of psilocybin on the in vivo binding of [11C]raclopride to D2-dopamine receptors in the striatum in healthy volunteers after placebo and a psychotomimetic dose of psilocybin (n = 7). Psilocybin is a potent indoleamine hallucinogen and a mixed 5-HT2A and 5-HT1A receptor agonist. Psilocybin administration (0.25 mg/kg p.o.) produced changes in mood, disturbances in thinking, illusions, elementary and complex visual hallucinations and impaired ego-functioning. Psilocybin significantly decreased [11C]raclopride receptor binding potential (BP) bilaterally in the caudate nucleus (19%) and putamen (20%) consistent with an increase in endogenous dopamine. Changes in [11C]raclopride BP in the ventral striatum correlated with depersonalization associated with euphoria. Together with previous reports of 5-HT receptor involvement in striatal dopamine release, it is concluded that stimulation of both 5-HT2A and 5-HT1A receptors may be important for the modulation of striatal dopamine release in acute psychoses. The present results indirectly support the hypothesis of a serotonin-dopamine dysbalance in schizophrenia and suggest that psilocybin is a valuable tool in the analysis of serotonin-dopamine interactions in acute psychotic states.  (+info)

Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. (5/276)

The central nervous system dopamine transporters (DATs) and dopamine D2/D3 receptors are implicated in a variety of neurological disorders. Both sites are also targets for drug treatment. With the successful development of [99mTc]TRODAT-1, single-isotope imaging studies using this ligand for DAT imaging can be complemented by additional use of 123I-labeled D2/D3 receptor ligand co-injected to assess both pre- and postsynaptic sites of the dopaminergic system simultaneously. METHODS: Twelve SPECT scans of the brain were obtained in two baboons after intravenous administration of 740 MBq (20 mCi) [99mTc]-TRODAT-1 (technetium, [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl ](2-mercaptoethyl) amino]ethyl]-amino]ethanethiolato (3-)]- oxo-[1R-(exo-exo)]) and 185 MBq (5 mCi) [123I]iodobenzamide or [123I]iodobenzofuran. SPECT data were acquired by a triple-head gamma camera equipped with ultra-high-resolution fanbeam collimators (scan duration = 210 min). Two sets of SPECT data were obtained using energy windows of 15% centered on 140 keV for 99mTc and 10% asymmetric with a lower bound at 159 keV for 123I. After coregistration with MRI, region-of-interest analysis was performed using predefined templates from coregistered MRI. In blocking studies, baboons were pretreated with N-methyl-2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CFT, 14 mg) or raclopride (14 mg) to block DAT or D2/D3 binding site, respectively. RESULTS: Image quality of dual-isotope studies was similar to that obtained from single-isotope studies. When one site was blocked with CFT or raclopride, the binding of the respective ligand to the other site was not affected. CONCLUSION: This is the first example that clearly demonstrates the feasibility of simultaneous imaging of both pre- and postsynaptic sites of the dopaminergic system in baboons with dual-isotope SPECT studies. With or without corrections for cross-contamination of 123I into the 99mTc window, striatum-to-cerebellum ratios (target-to-nontarget) of dual-isotope experiments did not differ significantly from single-isotope experiments. This method may be a valuable and cost-effective tool for gaining comprehensive information about the dopaminergic system in one SPECT imaging session.  (+info)

Striatal neuronal activity and responsiveness to dopamine and glutamate after selective blockade of D1 and D2 dopamine receptors in freely moving rats. (6/276)

Although striatal neurons receive continuous dopamine (DA) input, little information is available on the role of such input in regulating normal striatal functions. To clarify this issue, we assessed how systemic administration of selective D1 and D2 receptor blockers or their combination alters striatal neuronal processing in freely moving rats. Single-unit recording was combined with iontophoresis to monitor basal impulse activity of dorsal and ventral striatal neurons and their responses to glutamate (GLU), a major source of excitatory striatal drive, and DA. SCH-23390 (0.2 mg/kg), a D1 antagonist, strongly elevated basal activity and attenuated neuronal responses to DA compared with control conditions, but GLU-induced excitations were enhanced relative to control as indicated by a reduction in response threshold, an increase in response magnitude, and a more frequent appearance of apparent depolarization inactivation. In contrast, the D2 antagonist eticlopride (0.2 mg/kg) had a weak depressing effect on basal activity and was completely ineffective in blocking the neuronal response to DA. Although eticlopride reduced the magnitude of the GLU response, the response threshold was lower, and depolarization inactivation occurred more often relative to control. The combined administration of these drugs resembled the effects of SCH-23390, but whereas the change in basal activity and the GLU response was weaker, the DA blocking effect was stronger than SCH-23390 alone. Our data support evidence for DA as a modulator of striatal function and suggest that under behaviorally relevant conditions tonically released DA acts mainly via D1 receptors to provide a continuous inhibiting or restraining effect on both basal activity and responsiveness of striatal neurons to GLU-mediated excitatory input.  (+info)

Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms. (7/276)

Recently, zinc has been shown to modulate antagonist drug interactions with the D1 dopamine receptor (Schetz and Sibley, 1997) and the dopamine transporter (Norregaard et al., 1998). We now demonstrate that zinc also reversibly and dose-dependently modulates the specific binding of the butyrophenone antagonist [3H]methylspiperone to all D2-like dopamine receptors: D2L, D3, and D4. The molecular mechanisms of zinc regulation of these D2-like receptor subtypes are distinct because zinc inhibition of [3H]methylspiperone binding to the D4 receptor is noncompetitive by both equilibrium and kinetic measures (lower Bmax and essentially no change in koff), whereas the corresponding inhibition of zinc at D2L and D3 receptors is primarily characterized by competitive allosterism (increases in KD and koff). Interestingly, thermodynamic measurements reveal that the macroscopic properties of zinc binding are entropy-driven for all receptor subtypes, despite their having distinct molecular mechanisms. Zinc also reduces the binding affinity of the D2L receptor for [3H]raclopride, a structurally different antagonist of the substituted benzamide class. Sodium ions negatively modulate zinc inhibition of both sodium-insensitive [3H]methylspiperone binding and sodium-sensitive [3H]raclopride binding. In addition to its demonstrated effects on antagonist binding in membrane preparations, zinc also retards the functional effects of antagonist at the D2L receptor in intact cells. These findings suggest that synaptic zinc may be a factor influencing the effectiveness of therapies that rely on dopamine receptor antagonists.  (+info)

Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord. (8/276)

The analgesia-producing mechanism of processed Aconiti tuber was examined using rodents whose nociceptive threshold was decreased by loading repeated cold stress (RCS). The antinociceptive effect of processed Aconiti tuber (0.3 g/kg, p.o.) in RCS-loaded mice was antagonized by pretreatment with a kappa-opioid antagonist, nor-binaltorphimine (10 mg/kg, s.c.), and was abolished by an intrathecal injection of anti-dynorphin antiserum (5 microg). The Aconiti tuber-induced antinociception was inhibited by both dexamethasone (0.4 mg/kg, i.p.) and a dopamine D2 antagonist, sulpiride (10 mg/kg, i.p.), in RCS-loaded mice, and it was eliminated by both an electric lesion of the hypothalamic arcuate nucleus (HARN) and a highly selective dopamine D2 antagonist, eticlopride (0.05 microg), administered into the HARN in RCS-loaded rats. These results suggest that the analgesic effect of processed Aconiti tuber was produced via the stimulation of kappa-opioid receptors by dynorphin released in the spinal cord. It was also shown that dopamine D2 receptors in the HARN were involved in the expression of the analgesic activity of processed Aconiti tuber.  (+info)

Salicylamide - Get up-to-date information on Salicylamide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Salicylamide
The report generally describes 5-bromoacetyl salicylamide, examines its uses, production methods, patents. 5-Bromoacetyl salicylamide market situation
Salicylamide is a medicine available in a number of countries worldwide. A list of US medications equivalent to Salicylamide is available on the Drugs.com website.
Ethenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics.[citation needed] Darias, V.; Bravo, L.; Abdallah, S. S.; Sánchez Mateo, C. C.; Expósito-Orta, M. A.; Lissavetsky, J.; Manzanares, J. (1992). Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide. Archiv der Pharmazie. 325 (2): 83-87. doi:10.1002/ardp.19923250206. PMID 1605721. Wang, P. J.; Guo, H. R. (2004). Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs. The Journal of Headache and Pain. 5: 30. doi:10.1007/s10194-004-0065-x ...
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Plants can alter rates of electron transport through the alternative oxidase (AOX) pathway in response to environmental cues, thus modulating respiratory efficiency, but the 18O discrimination method necessary for measuring electron partitioning in vivo has been restricted to laboratory settings. To overcome this limitation, we developed a field-compatible analytical method. Series of plant tissue subsamples were incubated in 12 mL septum-capped vials for 0.5-4 h before aliquots of incubation air were injected into 3.7 mL evacuated storage vials. Vials were stored for up to 10 months before analysis by mass spectrometry. Measurements were corrected for unavoidable contamination. Additional mathematical tools were developed for detecting and addressing non-linearity (whether intrinsic or due to contamination) in the data used to estimate discrimination values. Initial contamination in the storage vials was 0.03 ± 0.01 atm; storing the gas samples at -17 °C eliminated further contamination ...
DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.. ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.. If this medicine makes it hard for you to sleep at night, take your last dose a few hours before bedtime.. Do not take other medicines that contain acetaminophen with ...
Solution and solid-state properties of m-hydroxybenzoic acid have been investigated. Two polymorphs were found where the monoclinic modification exhibits a higher stability than the orthorhombic form. The solubility of the monoclinic polymorph was determined between 10 and 50 degrees C in methanol, acetonitrile, acetic acid, acetone, water and ethyl acetate. The solubility of the orthorhombic polymorph was determined between 10 and 50 degrees C in acetonitrile, acetic acid, acetone and ethyl acetate. A thermodynamic analysis revealed a marked correlation between the molar solubility and the vant Hoff enthalpy of solution at constant temperature. In addition, in each solvent increased temperature resulted in increased vant Hoff enthalpy of solution. It is shown that the solubility data can be used to estimate melting properties for both polymorphs. The solubility ratio of the two forms and the DSC thermogram of the orthorhombic form strongly suggest that the system is monotropic. However, ...
Cefecon N information about active ingredients, pharmaceutical forms and doses by Nizhpharm, Cefecon N indications, usages and related health products lists
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
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Previous neurochemical and behavioural studies show that tyrosine depletion using a nutritionally balanced tyrosine-free amino acid mixture attenuates the dopamine-releasing and psychostimulant properties of amphetamine. Here we investigate the effect of a tyrosine-free amino acid mixture on striatal binding of [(11)C]raclopride, and amphetamine-induced [(11)C]raclopride displacement, using positron emission tomography in the rat. Rats were scanned for 60 min after an i.v. injection of approximately 11 MBq [(11)C]raclopride using a quad-HIDAC system. Amphetamine (2 mg/kg i.p., 30 min prior to scan) caused a 12% reduction in [(11)C]raclopride distribution volume ratio (DVR) compared to saline-injected controls. The tyrosine-free amino acid mixture (1 g/kg i.p.) caused a small (+7%) but statistically insignificant increase in [(11)C]raclopride DVR and attenuated, although it did not fully block, the amphetamine-induced reduction. These data are in keeping with previous neurochemical, immunocytochemical,
Ascorbate peroxidase is a bifunctional peroxidase that catalyzes the H(2)O(2)-dependent oxidation of both ascorbate and various aromatic substrates. The ascorbate binding site was recently identified as being close to the gamma-heme edge [Sharp, K. H., Mewies, M., Moody, P. C. E., and Raven, E. L. (2003)Nat. Struct. Biol. 10, 303-307]. In this work, the X-ray crystal structure of recombinant soybean cytosolic ascorbate peroxidase (rsAPX) in complex with salicylhydroxamic acid (SHA) has been determined to 1.46 A. The SHA molecule is bound close to the delta-heme edge in a cavity that connects the distal side of the heme to the surface of the protein. There are hydrogen bonds between the phenolic hydroxide of the SHA and the main chain carbonyl of Pro132, between the carbonyl oxygen of SHA and the side chain guanadinium group of Arg38, and between the hydroxamic acid group and the indole nitrogen of Trp41. The structure provides the first information about the location of the aromatic binding site ...
Comprehensive alcohol & food interactions for Saleto-D (acetaminophen / caffeine / phenylpropanolamine / salicylamide). Includes High Blood Pressure (Hypertension), High Blood Pressure (Hypertension)
Type I : R action immunologique de type imm diat m diation par les IgE. M dicaments (p nicilline). Elle se manifeste sous la forme d urticaire et d angio- d me de la peau et des muqueuses, d d me d autres organes et d une chute de la pression art rielle (choc anaphylactique). Elle survient plus fr quemment, lorsque le m dicament est administr par voie intraveineuse que par voie buccale.. Type II : R actions cytotoxiques Les m dicaments (p nicilline, c phalospoprines, sulfonamides, rifampicine) et les anticorps cytotoxiques entra nent une lyse cellulaire comme par exemple des plaquettes et des leucocytes. D autres m dicaments (quinine, quinidine, salicylamide, isoniazide, chlorpromazine, sulfonamides, sulfonylur es) associ s aux anticorps (en formant des complexes immuns) peuvent entra ner une lyse ou une phagocytose.. Type III : Maladie s rique, vascularite induite par les m dicaments IgG ou moins fr quemment, IgM dirig es contre les m dicaments. Cette r action est induite par le d p t de ...
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
Downloadable! A universal type space of interdependent expected utility preference types is constructed from higher-order preference hierarchies describing (i) an agents (unconditional) preferences over a lottery space; (ii) the agents preference over Anscombe-Aumann acts conditional on the unconditional preferences; and so on. Two types are said to be strategically indistinguishable if they have an equilibrium action in common in any mechanism that they play. We show that two types are strategically indistinguishable if and only if they have the same preference hierarchy. We examine how this result extends to alternative solution concepts and strategic relations between types.
Sex-dependent changes in ADHD-like behaviors in juvenile rats following cortical dopamine depletion. Behav Brain Res. 2014 Aug 15; 270:357-63 ...
Feather-Lite batteries is proud to offer a marine series batteries customer have asked for. This battery is designed for customers with 12-volt trolling motors looking to get the most trolling time out of a single battery. This battery offers 100-amp hours of comparable lead acid capacity.
Salicylamide O-Acetate sodium Salt Report by Material, Application, and Geography - Global Forecast to 2020 is a professional and in-depth research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, united Kingdom, Japan, South Korea and China).
We measured the long-term test-retest reliability of [C-11]raclopride binding in striatal subregions, the thalamus and the cortex using the bolus-plus-infusion method and a high-resolution positron emission scanner. Seven healthy male volunteers underwent two positron emission tomography (PET) [C-11]raclopride assessments, with a 5-week retest interval. D-2/3 receptor availability was quantified as binding potential using the simplified reference tissue model. Absolute variability (VAR) and intraclass correlation coefficient (ICC) values indicated very good reproducibility for the striatum and were 4.5%/0.82, 3.9%/0.83, and 3.9%/0.82, for the caudate nucleus, putamen, and ventral striatum, respectively. Thalamic reliability was also very good, with VAR of 3.7% and ICC of 0.92. Test-retest data for cortical areas showed good to moderate reproducibility (6.1% to 13.1%). Our results are in line with previous test-retest studies of [C-11]raclopride binding in the striatum. A novel finding is the ...
The data provide two examples of cross talk between plastids and mitochondria. First, silencing mitochondrial ISE1 reduces the redox state of plastids. Second, paraquat induces an oxidative shift in both chloroplasts and mitochondria, which negatively regulates intercellular transport via PD. Because salicylhydroxamic acid induces oxidative shifts in mitochondria, leading to increased PD transport, the paraquat-induced oxidative shift in chloroplasts must override mitochondrial oxidative shifts. These data are supported by independent microarray studies of ise1 and ise2 mutants, demonstrating that loss of either ISE1 or ISE2 function has numerous common effects in plastid-targeted gene expression (including down-regulation of ISE2 transcription) but little common impact on mitochondria-targeted gene expression (Burch-Smith et al., 2011a). Note further that plastid and mitochondrial retrograde signaling to the nucleus can both be initiated by changes in the redox state of these organelles ...
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1952 OHMS envelope from The Postmaster General P.M. Watson addressed to London cancelled CAUSEWAY c.d.s. 31 MAY 52 alongside OFFICIAL PAID S RHODESIA c.d.s. 31MAY 52 struck in red. At the bottom left corner POSTAL SERVICE G.P.O. S RHODESIA c.d.s. of the same date. A fine trio of cancellations ...
The data below is based on a Stitch DB API call for human protein-drug interactions for Propyl gallate Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.. ...
Cryptococcus neoformans is an environmental encapsulated yeast that behaves as an opportunistic pathogen in immunocompromised individuals. The capsule is the main virulence factor of this pathogen. This structure is highly dynamic, and it can change its size and structure according to the environmental conditions. During infection, C. neoformans significantly enlarges the size of the capsule by the addition of new polysaccharide. It is believed that capsule growth is an energy-cost process, but this aspect has never been addressed. In this work, we have evaluated the role of mitochondrial activity on capsule growth using specific inhibitors of the electron respiratory chain. We observed that capsule growth was impaired in the presence of inhibitors of the respiratory chain as salicylhydroxamic acid (SHAM) or antimycin A. Furthermore, capsule growth correlated with an increase of the mitochondrial membrane potential and higher production of reactive oxygen species. Our results confirm that capsule growth
BACKGROUND: Acute depletion of tyrosine using a tyrosine-free amino acid mixture offers a novel dietary approach to inhibit activated dopamine pathways in the brain. This study investigated the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a noninvasive means to detect effects of tyrosine depletion on dopamine function. METHODS: Changes in blood-oxgenation level dependent (BOLD) contrast induced by administration of the dopamine-releasing agent, amphetamine (3 mg/kg i.v.), were measured in halothane-anaesthetised rats. RESULTS: Amphetamine evoked changes in BOLD signal intensity with the greatest effects observed in the nucleus accumbens (-7.7%), prefrontal cortex (-13.6%), and motor cortex (+12.5%). Pretreatment with a tyrosine-free amino acid mixture attenuated the response to amphetamine in some regions (nucleus accumbens and prefrontal cortex), but not others (motor cortex). Amphetamine itself had no effect in thalamus and hippocampus but, surprisingly, increased the
Tritium labelled Raclopride; Tritium labeled Raclopride; 3H Raclopride; H-3 Raclopride;Tritium labelled 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide; Tritium labeled 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide; H-3 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide; 3H 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
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In January of 2001, I began an internship at Trolltechs embedded development office in Brisbane, Australia. My goal was twofold: to learn C++ and to learn how to develop embedded applications.
The ribbed mussel Geukensia demissa inhabits intertidal Spartina grass marshes characterized by sulfide-rich sediments. Sulfide poisons aerobic respiration, and G. demissa may cope in this seemingly inhospitable environment by oxidizing sulfide in gill mitochondria. Well-coupled mitochondria isolated from G. demissa gills were used to investigate sulfide oxidation and ATP synthesis. State 3 respiration, maximally stimulated by 5 micromol l(−)(1) sulfide with a P/O ratio of 0.89 and a respiratory control ratio (RCR) of 1.40, remained refractory to sulfide at higher concentrations except in the presence of salicylhydroxamic acid (SHAM), an inhibitor of alternative oxidases. Sulfide-stimulated ATP production was 3-5 times greater than that stimulated by malate and succinate, respectively, giving an ATP/sulfide ratio of 0.63. The inhibition of sulfide-stimulated respiration and ATP production by the complex III inhibitors myxothiazol and antimycin A, respectively, suggests that electrons enter the ...
We have used salicylhydroxamic acid (SHAM) to inhibit intraphagosomal myeloperoxidase activity in order to evaluate the role of this enzyme in the killing of Staphylococcus aureus by human neutrophils. 50 µm-SHAM reduced the luminol-dependent chemiluminescence response stimulated during phagocytosis of unopsonized latex beads and opsonized S. aureus by over 80% and 60%, respectively. When opsonized S. aureus were incubated with neutrophils, 45% were killed within 15 min incubation and 60% by 1 h. However, in neutrophil suspensions incubated with 50 µm-SHAM, only 13% were killed by 15 min whilst 71% still remained viable after 1 h. This inhibitor had no effect upon the number of bacteria phagocytosed or upon degranulation. In a cell-free system, 2·5 µm-H2O2 alone killed 55% of the bacteria, whereas in the presence of myeloperoxidase (i.e. 10 mU myeloperoxidase and 2·5 µm-H2O2) virtually all of the bacteria were killed: the addition of 50 µm-SHAM abolished this myeloperoxidase-enhanced killing but
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BACKGROUND Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for the differentiation of Parkinsons disease from atypical parkinsonian syndromes. Comparison with reference values is recommended to establish a reliable diagnosis. A PET template specific to raclopride may facilitate direct computation of parametric maps without the need for an additional MR scan, aiding automated image analysis. METHODS Sixteen healthy volunteers underwent a dynamic 11C-raclopride PET and a high-resolution T1-weighted MR scan of the brain. PET data from eight healthy subjects was processed to generate a raclopride-specific PET template normalized to standard space. Subsequently, the data processing based on the PET template was validated against the standard magnetic resonance imaging (MRI)-based method in 8 healthy subjects and 20 patients with suspected ...
Arbuscular mycorrhizal fungi (AMF) are necessary the different parts of fertile soils, in a position to provide many ecosystem services for crop production. string components, choice oxidase (AOX) and cytochrome oxidase (COX), get Mmp2 excited about particular mycorrhizal behavior. Because of this, a organic approach originated. On the pre-symbiotic stage (axenic circumstances), we examined phenotypic replies of spores with two AOX and COX inhibitors [respectively, salicylhydroxamic acidity (SHAM) and potassium cyanide (KCN)] and two development regulators (abscisic acidity C ABA and gibberellic acidity C Ga3). On the symbiotic stage, we examined phenotypic and transcriptomic (genes involved with respiration, transportation, and fermentation) replies in biosystem (glasshouse circumstances): we supervised the effects powered by ABA, and explored the modulations induced by SHAM and KCN under five phosphorus concentrations. KCN and SHAM inhibited spore germination while ABA and Ga3 induced ...
Shennan, D. H. (1965). Towards the rout of tuberculosis in Rhodesia Part 3 : Investigation and planning. The Central African Journal of Medicine, 11, (8), 260-264 ...
Southern Rhodesia, Central Africa: March, 1914. A trooper of police, sent to contain a lawless settlement near Bulawayo, the countrys largest city, told on his arrival there that all the violence was caused by government restrictions (not true) took them at their word and made a single, simple
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The Crisis of Civilization is a documentary feature film investigating how global crises like ecological disaster, financial meltdown, dwindling oil...
Acetanilide and derivatives of benzoic acid, benzamide, salicylic acid, and salicylamide were tested as inhibitors of p-aminobenzoic acid N-acetyltransferase partially purified from peripheral blood of three rapid and two slow dapsone acetylator human volunteers. The 50% inhibition point of these compounds does not provide a kinetic basis for differentiating the rapid and slow dapsone acetylator phenotypes. ...
SKU: H-426 Extra-strength pain reliever tablets, 2 per pack - 100 per box Comparable to Excedrin®, our extra-strength pain reliever provides temporary relief from the pain and pressure of headaches, sinusitis and toothaches. Also relieves minor arthritis and rheumatism pain, hangovers and aches associated with cold and flu. Active ingredients: Acetaminophen, 100 mg.; Aspirin, 162 mg.; Salicylamide, 152 mg.; Caffeine, 32.4 mg.. Extra-strength pain reliever tablets. Northwest Health and Safety offers a wide range of stocked First Aid Kits, Survival and Emergency Kits. We also offer all of the refill products as well so you can pick and choose for your specific needs. Northwest Health and Safety offers empty First Responder Bags, as well as plastic or metal First Aid containers that you can tailor fill for your specific industry demands ...
The function of striatopallidal neurons is regulated by N-methyl-d-aspartate (NMDA) and dopamine D2 receptors. Previous studies show that immediate early gene induction by D2 receptor blockade is suppressed by NMDA receptor antagonists. Because the pharmacology of NMDA receptors depends on the incorporation of different NR2 subunits and NR2 subunits show regional and cellular differences in their expression in striatum, our study examined whether different NMDA receptor antagonists would have differential effects on eticlopride-induced immediate early gene expression in striatum. Male Sprague-Dawley rats were pretreated with vehicle, CGS 19755, MK-801 or ifenprodil. Rats then received injections of eticlopride and were killed 40 min later. In situ hybridization histochemistry was used to determine the expression of c-fos andzif268 in the striatum. Eticlopride increased immediate early gene expression in striatum, with the increase generally being greater in lateral than in medial striatum. ...
To compare the newer inductor of platelet aggregation cationic propyl gallate (CPG) with adenosine diphosphate (ADP) for the examination of aspirin (ASA) effectivity with optical aggregometry. In total,116 patients were prospectively enrolled with a stable cardiovascular disease, taking ASA 100 mg/day for |or=1 month. The control group consisted of 62 healthy volunteers. A platelet aggregation was investigated by optical aggregometry (aggregometer LASER 4x; BIO ART, Sint-Katelijne-Waver, Belgium). CPG and ADP were added as aggregating agents. The measured parameters were CPG-slope (%/min) and ADP max (%). Using the CPG-slope values from the control group, the CPG-slope cut-off value was determined to define a laboratory ASA-noneffectively treated patient. The values from control group followed a normal distribution (Shapiro-Wilk test). We calculated the cut-off value using the 1-tailed 95% confidence interval. The CPG-slope cut-off value was 79 %/min for an ASA-effectively treated patient. We marked the
The UK annexed Southern Rhodesia from the former British South Africa Company in 1923. A 1961 constitution was formulated that favored whites in power. In 1965 the government unilaterally declared its independence, but the UK did not recognize the act and demanded more complete voting rights for the black African majority in the country (then called Rhodesia). UN sanctions and a guerrilla uprising finally led to free elections in 1979 and independence (as Zimbabwe) in 1980. Robert MUGABE, the nations first prime minister, has been the countrys only ruler (as president since 1987) and has dominated the countrys political system since independence. His chaotic land redistribution campaign, which began in 1997 and intensified after 2000, caused an exodus of white farmers, crippled the economy, and ushered in widespread shortages of basic commodities. Ignoring international condemnation, MUGABE rigged the 2002 presidential election to ensure his reelection. In April 2005, the capital city of ...
Abstract The prevalence of schistosomiasis has been measured by parasitological examination and by fluorescent antibody titering in a number of communities in different parts of Rhodesia. The samples were taken from areas of high, medium, and low transmission of the disease. A correlation was detected between the mean titer and prevalence of infection, particularly in the younger people (4-13 yars old). It is suggested that fluorescent antibody titrating may be a useful epidemiological tool.
A survey of the protozoan and helminth species which infest the intestines of the people in the Inyanga area of Rhodesia has revealed a wide range of species.
During his recuperation Formby contracted gastroenteritis and had a suspected blood clot on his lung, after which he underwent an operation to clear a fishbone that was stuck in his throat.[158] He had recovered sufficiently by April 1953 to undertake a 17-show tour of Southern Rhodesia (now Zimbabwe), before a special appearance at the Southport Garrick Theatre. That September he turned on the Blackpool Illuminations.[159] From October to December 1953 Formby appeared at the London Palladium in 138 performances of the revue Fun and the Fair, with Terry-Thomas and the Billy Cotton band; Formby appeared in the penultimate act of the evening, with Terry-Thomas closing the show.[160][161] Although Formbys act was well-received, the show was not as successful as had been hoped, and Terry-Thomas later wrote that Formby put the audience in a certain mood which made them non-receptive to whoever followed ... Even though my act was the star spot, I felt on this occasion that my being there was an ...
Rhodesia_A partir del període dentreguerres, es va instaurar a Rhodèsia (Colònia britànica fins al 1979) un règim racista i segregacionista en el qual la minoria blanca (5% de la població) va tenir sotmesa a la majoria negra originària del lloc. Es coneix com la Sud-àfrica de lApartheid Bis.. ...
Dopacard infusion contains the active ingredient dopexamine hydrochloride, which is a type of medicine called a sympathomimetic stimulant.
PSEE), and CO FLB, Africa & Soviet, two such RPF characters. Sea Org Member but relatively appeared a performance. IMO HCO, was not to LRH.
Salicylamides are one type of drug. It has been used as an antiseptic based on the antibacterial activity upon hydrolysis in ...
"Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras". Organic Letters. 16 (19): 5036-9. doi:10.1021/ ...
Imramovský A, Pauk K, Padělková Z, Hanusek J. Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of the H- ... Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of the H-bonding Influenced Linear Chain Formation in ... Imramovský, A.; Pauk, K.; Padělková, Z.; Hanusek, J. Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of ... "Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of the H-bonding Influenced Linear Chain Formation in ...
Salicylamides / pharmacology * Soybeans / enzymology * Succinic Acid / metabolism Substances * Antioxidants * Enzyme Inhibitors ...
Salicylamides / chemical synthesis* * Salicylamides / chemistry * Salicylamides / pharmacology * Structure-Activity ...
Method of preparing salicylamides. US20030225300 *. 20 Jun 2003. 4 Dec 2003. Emisphere Technologies Inc.. Compounds and ... Method of preparing salicylamides. US7279597. 6 Nov 2000. 9 Oct 2007. Emisphere Technologies, Inc.. Phenyl amine carboxylic ... Method of preparing alkylated salicylamides via a dicarboxylate intermediate. US20060121066 *. 27 Jan 2005. 8 Jun 2006. David ... Manufacture process of n-substituted salicylamides. EP1175390A1 *. 5 Apr 2000. 30 Jan 2002. Emisphere Technologies, Inc.. ...
Activity of selected salicylamides against intestinal sulfate-reducing bacteria.. Kushkevych I, Kollar P, Suchy P, Parak T, ... OBJECTIVES: The aim of our work was to evaluate effect of selected salicylamides on cell viability of sulfate-reducing ... Kushkevych I, Kollar P, Suchy P, Parak T, Pauk K, Imramovsky A. Activity of selected salicylamides against intestinal sulfate- ...
Activity of selected salicylamides against intestinal sulfate-reducing bacteria. Kushkevych I, Kollar P, Suchy P, Parak T, Pauk ... Kushkevych I, Kollar P, Suchy P, Parak T, Pauk K, Imramovsky A. Activity of selected salicylamides against intestinal sulfate- ... Salicylamides:pharmacology,. Read abstract Full text PDF ...
0/Salicylamides; 80751-65-1/SK&F 82958; 84225-95-6/Raclopride ...
Suitable antibacterial agents include, phenolics and salicylamides. Such antibacterial agents, in addition to other functional ...
Method of relieving pain and inflammatory conditions employing substituted salicylamides. US4582717. 27 Jul 1984. 15 Apr 1986. ...
Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.. Salim AA, Cho KJ, Tan L, Quezada M, Lacey E, Hancock ...
Salicylamides. Alternative Parents. Benzoyl derivatives / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted ... This compound belongs to the class of organic compounds known as salicylamides. These are carboxamide derivatives of salicylic ...
Salicylamides [D02.065.793]. *Labetalol [D02.065.793.324]. *Amines [D02.092]. *Amino Alcohols [D02.092.063] ...
Salicylamides 5. Polyenes 6. Nystatin (Mycostatin) 7. Minoxidil (Rogaine) 8. Ketoconazole (Nizoral) ...
2014). Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Org. Lett. 16, 5036-5039. doi: 10.1021/ol502376e ...
Furthermore, it has been found that the novel substituted acylamino-salicylamides of the general formula (I) are obtained when ...
Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.. Acta Pharmacol Toxicol (Copenh) ...
Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Org Lett 16:5036-5039. doi:10.1021/ol502376e. ...
N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors Fritzson, Ingela LU ; ...
Method of relieving pain and inflammatory conditions employing substituted salicylamides US4582717A (en) 1982-02-06. 1986-04-15 ... Method of relieving pain and inflammatory conditions employing substituted salicylamides US4693705A (en) 1984-04-09. 1987-09-15 ...
SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of ... we identified several salicylamides that are potent inhibitors of acute leukemia cell viability through inhibition of CREB-CBP ...
For metal complex formation with linear bis-catechol amides and linear bis-salicyl-amides, see: Duhme et al. (1996. ); Huang et ... For metal complex formation with linear bis-catechol amides and linear bis-salicylamides, see: Duhme et al. (1996); Huang et al ... forming a six-membered ring structure which is quite often observed for salicylamides. Additionally, the aliphatic hydroxy ...
Salicylamides *Sulfonamides *Thioamides *Fatty amides An amide is hydrolyzed to yield an amine and a carboxylic acid under ...
Michio K (1976) The dual fluorescence nature of some n-monosubstituted salicylamides. Bull Chem Soc Jpn 49:2679-2682CrossRef ...
Method of relieving pain and inflammatory conditions employing substituted salicylamides US4921694A (en) 1990-05-01. ... Method of relieving pain and inflammatory conditions employing substituted salicylamides US6607716B1 (en) 2003-08-19. ...
Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the ... Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the ...
The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof and their derivatives ...
Salicylamides, Saliva, Schizophrenia, Schizophrenic Psychology, Scopolamine Hydrobromide, Second Messenger Systems, Seizures, ...
Salicylamides are one type of drug. It has been used as an antiseptic based on the antibacterial activity upon hydrolysis in ...
"Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras". Organic Letters. 16 (19): 5036-9. doi:10.1021/ ...
Antibacterial agents include for example phenolics and salicylamides, and sources of certain metal ions such as zinc, copper, ...
  • Effects of remoxipride and some related new substituted salicylamides on rat brain receptors. (abcam.com)