Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Dairy Products: Raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo.Consumer Product SafetyGlycosylation End Products, Advanced: Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Meat Products: Articles of food which are derived by a process of manufacture from any portion of carcasses of any animal used for food (e.g., head cheese, sausage, scrapple).Kinetics: The rate dynamics in chemical or physical systems.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Genes, Bacterial: The functional hereditary units of BACTERIA.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Household Products: Substances or materials used in the course of housekeeping or personal routine.Bacterial Proteins: Proteins found in any species of bacterium.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Molecular Weight: The sum of the weight of all the atoms in a molecule.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Poultry Products: Food products manufactured from poultry.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Protein Biosynthesis: The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Viral Proteins: Proteins found in any species of virus.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Tobacco Products: Substances and products derived from NICOTIANA TABACUM.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Genes, Viral: The functional hereditary units of VIRUSES.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Fish Products: Food products manufactured from fish (e.g., FISH FLOUR, fish meal).Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Cell-Free System: A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Product Packaging: Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Genes, Fungal: The functional hereditary units of FUNGI.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Food Microbiology: The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.Lipoxygenase: An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Genes, Regulator: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.Fungal Proteins: Proteins found in any species of fungus.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Protein PrecursorsStructure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Blotting, Northern: Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Maillard Reaction: One of a group of nonenzymatic reactions in which aldehydes, ketones, or reducing sugars react with amino acids, peptides, or proteins. Food browning reactions, such as those that occur with cooking of meats, and also food deterioration reactions, resulting in decreased nutritional value and color changes, are attributed to this reaction type. The Maillard reaction is studied by scientists in the agriculture, food, nutrition, and carbohydrate chemistry fields.Biodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Food Contamination: The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Oxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Mutagenesis, Insertional: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Lipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.Chromatography, Ion Exchange: Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.Bacillus subtilis: A species of gram-positive bacteria that is a common soil and water saprophyte.Isomerism: The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Tobacco, Smokeless: Powdered or cut pieces of leaves of NICOTIANA TABACUM which are inhaled through the nose, chewed, or stored in cheek pouches. It includes any product of tobacco that is not smoked.Food Analysis: Measurement and evaluation of the components of substances to be taken as FOOD.Legislation, Food: Laws and regulations concerned with industrial processing and marketing of foods.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.KetonesOxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Lysine: An essential amino acid. It is often added to animal feed.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)DNA Replication: The process by which a DNA molecule is duplicated.Milk: The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cultured Milk Products: Milk modified with controlled FERMENTATION. This should not be confused with KAFFIR LIME or with KAFFIR CORN.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Meat: The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Fibrin Fibrinogen Degradation Products: Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Glycoside HydrolasesHydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Anaerobiosis: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.beta-Galactosidase: A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.Endopeptidases: A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Hydroxyeicosatetraenoic Acids: Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Plant Preparations: Material prepared from plants.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
  • 2) The effects we demonstrate were obtained by a short exposure time (minutes) of the cells to glyphosate-based products, and nothing excludes that prolonged exposure to lower doses may also have effects. (greenmedinfo.com)
  • The average American uses about 10 personal care products each day, resulting in exposure to some 100 unique chemicals. (thegoodhuman.com)
  • A dab here or there on the skin is unlikely to cause harm but prolonged exposure - such as rubbing a large amount of a retinoid product into the skin or using a face mask containing salicylic acid - could be risky. (onemedical.com)
  • Such information would provide opportunities for identifying products-and the potentially harmful ingredients they contain-to allow consumers to reduce their exposure. (futurity.org)
  • With endometriosis rates soaring in young women, one has to wonder if chronic exposure to low levels of dioxin residues from sanitary products could partly be to blame? (thehealthyhomeeconomist.com)
  • A multidisciplinary approach was utilized to implement several P&Ps at the UNC Cancer Hospital Infusion/Inpatient Pharmacy (CHIP) to reduce exposure risk and create safe handling practices. (pppmag.com)
  • However, that doesn't mean that they believe mercury fillings are a health hazard, or will use established and safe removal protocols to protect patients from excessive exposure to mercury during amalgam removal. (trustedhealthproducts.com)
  • Mercury safe dentists also have the specialized equipment, training, experience and skills necessary to minimize your exposure to mercury during amalgam removal. (trustedhealthproducts.com)
  • Another advantage of going to a mercury safe dentist is that you wont have to debate why you believe amalgam fillings are a health hazard, why you want them removed, and why you want to minimize your exposure to mercury during the process. (trustedhealthproducts.com)
  • When testing ingredients for harmful effects, the accumulative and also the combined effects, (how one ingredient may react negatively with another ingredient)are often unable to be tested and measured in humans and this is somehow being overlooked, or swept under the carpet and products get released. (livingsafe.com.au)
  • One of the issues with ratings in the skindeep database: if they do not have any information on the ingredient, they give it a "0" rating, which can lower the over all score for a product in the database. (thegoodhuman.com)
  • Avoid products that have "fragrance" on the ingredient list. (onemedical.com)
  • To avoid salicylic acid, do not use products with beta hydroxy acid (BHA) listed as an ingredient. (onemedical.com)
  • Given the near total lack of availability of potassium chloride for injection concentrate in vials (2 mEq/mL), along with problems accessing the 250 mL pharmacy bulk package (2 mEq/mL), some healthcare providers have benefitted from outsourcing facilities that have compounded this product starting with the active pharmaceutical ingredient (API). (ismp.org)
  • Revitalash used to be based on an ingredient called bitamoprost (this is what prompted the FDA recall of Jan Marini's original product). (truthinaging.com)
  • Walmart recognizes that it still has work to do with suppliers to improve ingredient disclosure, so existing commitments still stand, including a 2018 deadline for better ingredient disclosure on product labels. (edf.org)
  • This commitment reflects the demands of over 80% of global consumers for greater ingredient transparency when shopping for personal care and household cleaning products. (edf.org)
  • EMBARGOED UNTIL [09.00 GMT Friday 16th June 2017, Warsaw, Poland] New data analysis presented today at the annual Global Forum on Nicotone (GFN) meeting demonstrates the potential of the low risk tobacco product snus in reducing the impact of tobacco related disease and death in Europe. (eurekalert.org)
  • Reporting due on January 31, 2019 must be based on CHCCs in children's products offered for sale within the state of Washington between September 1, 2017 and December 31, 2018. (bureauveritas.com)
  • Carbondale, PA, October 27, 2017 Gentex Corporation, a global leader in personal protection and situational awareness solutions for defense forces, emergency responders, and industrial personnel will introduce several new hearing protection and communication products to the U.S. market at this year's SAFE Symposium, featuring the Gentex Wire-Free Communication Earplugs (WCEP). (gentexcorp.com)
  • When using these products, monitor your pet for any signs of an adverse reaction, including anxiousness, excessive itching or scratching, skin redness or swelling, vomiting, or any abnormal behavior. (avma.org)
  • And most importantly, report these incidents to your veterinarian and the manufacturer of the product so adverse event reports can be filed. (avma.org)
  • However, there is not a whole lot of testing to make sure that the ingredients in these products won't have an adverse impact on your health. (futurity.org)
  • Certain kinds of weight-loss drugs and natural health products may interact with each other, with foods you eat, or with other medications you take, increasing the risk of adverse reactions. (canada.ca)
  • And despite their wholesome image, many herbal products have adverse effects and may have dangerous interactions with other drugs and dietary supplements. (highlighthealth.com)
  • The Act mandates reporting requirements by medical device manufacturers regarding adverse safety events and product effectiveness of devices classified as substantially equivalent to Class III medical devices. (wikipedia.org)
  • If you have questions about best skin care products, or best skin treatment options for various problems or needs, search in the top header for existing content, or click "ask a question" to submit your own! (skintour.com)
  • Although medicines and pesticides must meet U.S. government-required safety standards before they can be sold, it is still critical that pet owners carefully consider their flea and tick preventive options (and closely read the label) before they treat their pets with one of these products. (avma.org)
  • Check to see if a toy has been recalled by the Consumer Product Safety Commission (CPSC) on their recall page . (kidshealth.org)
  • Safety always has been a cornerstone of our work in product development. (xerox.com)
  • Our comprehensive Product Safety Plan details our health and safety requirements, and all Xerox imaging equipment is assessed for conformance to these standards. (xerox.com)
  • Customers are encouraged to review product safety information and understand the environmental profile of our devices. (xerox.com)
  • Our Product Safety Data Sheets (PSDS) offer environmental, health and safety information for each Xerox device. (xerox.com)
  • In today's products, Nu Skin ensures that all ingredients are obtained from reliable suppliers who have thoroughly tested the ingredients and established a good safety profile. (nuskin.com)
  • Additionally, once formulated in a product, Nu Skin R&D performs a battery of clinical testing which confirms the safety of the final product. (nuskin.com)
  • Since the publication of the Institute of Medicine's report, To Err is Human: Building a Safer Health Care System , 3 the safety of medications, and of patients in general, has caught the attention of the general public and hospital healthcare practitioners. (bmj.com)
  • Senator Claire McCaskill speaks of the years when she used to buy Thomas the Tank Engine for her children…knowing it was a basic, safe toy….and how disappointed she and other parents are to know that the Consumer Product Safety Commission has let thousands of those toys get into children's hands despite lead-contaminated paint. (missourinet.com)
  • Keep People Safer on ATVs Offering a concise overview of ATV safety, this colorful free standing display describes how all terrain vehicle injuries most often occur and complements the 'Safe to the Xtreme' ATV activity book. (imsafe.com)
  • Knowing what kind of product to use, and how to use it, is critical to the health and safety of your pet. (avma.org)
  • Unfortunately for American consumers, these products aren't held to the same high safety standard as foods and drugs in the United States, and as such manufacturers do not have to disclose ingredients on their products' labels. (thegoodhuman.com)
  • take a look inside This Road Warriors Safe to the Xtreme Activity Book teaches pre-teens about occupant protection and car safety. (imsafe.com)
  • Demystify your laundry routine by consulting EWG's Clean Laundry Guide , which ranks hundreds of products on their health and environmental safety, and check out a few of these great eco-friendly and DIY options. (mindbodygreen.com)
  • Everyone's favorite boredom distraction has become so much of an issue that the Consumer Product Safety Commission deemed them an "emerging hazard" and recommends that parents keep a close eye on children of all ages when they are using them. (wpbf.com)
  • The reason: The U.S. Consumer Products Safety Commission warned that if the small toy was ingested, it could expand inside a child's body and cause intestinal obstructions and lead to severe discomfort, vomiting, dehydration and life-threatening complications. (wpbf.com)
  • The popular rattles were recalled earlier this year after the U.S. Consumer Product Safety Commission found that the disc that holds the spherical toy together can break, making the beads inside easily accessible for young children. (wpbf.com)
  • Working with its member companies , ACC developed the Responsible Care® Product Safety Code to drive continuous improvement in chemical product safety. (americanchemistry.com)
  • The Product Safety Code is our industry's public commitment to our role in the safe management of chemicals and articulates our pledge to make safety a core value in how our products are made, sold, delivered, used and disposed of. (americanchemistry.com)
  • Governments worldwide establish chemical safety guidelines and regulations, and the United Nations and other international organizations work to promote safe use of chemical products globally. (americanchemistry.com)
  • In the United States, the U.S. Environmental Protection Agency (EPA) is the primary regulator of the safety of chemical products in commerce under The Frank R. Lautenberg Chemical Safety for the 21st Century Act (LCSA). (americanchemistry.com)
  • Assess the labeling and packaging of all products from outsourcing facilities for safety. (ismp.org)
  • Researchers from the University of Leeds aimed to determine the appropriateness of safety information provided with a select set of common herbal products that could be purchased in the United Kingdom. (highlighthealth.com)
  • The information provided with these products was compared to safety information provided by the National Center for Complementary and Alternative Medicine (NCCAM) , and was evaluated for completeness and accuracy regarding precautions, interactions with other drugs, and side effects. (highlighthealth.com)
  • The finding is consistent with 2008 study in the U.S., which found that the vast majority of St John's wort products fail to adequately address clinically relevant safety issues on their labeling . (highlighthealth.com)
  • It is also paramount that adherence to hygiene and safety standards does not adversely affect the product quality and efficiency of a factory line. (provisioneronline.com)
  • Although obtaining the desired cooling effect remains the top priority, the industry is seeing a trend toward more integrated products that complement the design of the vehicle and increase passenger safety. (schoolbusfleet.com)
  • Providing accurate health information is part of the basis for obtaining "informed consent" and is a recognised component of business ethics, safety communications, and case and product liability law. (bmj.com)
  • The Act of Congress transferred the electronic product radiation control provisions established by the Radiation Control for Health and Safety Act. (wikipedia.org)
  • In June 2014, FDA released a draft guidance document, Determining the Need for and Content of Environmental Assessments for Gene Therapies, Vectored Vaccines, and Related Recombinant Viral or Microbial Products . (raps.org)
  • User guides contain information regarding safe use as well as any applicable hazard warnings. (xerox.com)
  • Toxicologists conduct a comprehensive assessment of new materials in our products to ensure conformance with applicable global registration, hazard communication and waste handling and disposal requirements. (xerox.com)
  • It's no secret that small bead-like objects can pose as a choking hazard for young kids, but sometimes, the parts may be hiding in other seemingly safe toys. (wpbf.com)
  • These federally mandated words indicate the degree of immediate hazard posed by the product. (cityofarcata.org)
  • Walmart's policy expands on the three original commitments of the Sustainable Chemistry Policy: "Transparency," "Advancing Safer Formulations," and product leadership in a section now titled, "Advancing Our Assortment. (edf.org)
  • The biggest changes in Walmart's new policy appear in its "Advancing Safer Formulations" section. (edf.org)
  • This article outlines the Nu Skin philosophy to only develop and sell 'safe' personal care products and discusses some of the hot items getting attention in the press and online. (nuskin.com)
  • Labeling on baby personal care products can be disconcertingly misleading. (livingsafe.com.au)
  • That means it's up to consumers to educate themselves as how to find safe personal care products to buy and which to avoid if human health and the environment are concerns. (thegoodhuman.com)
  • Botanical ingredients do not have the same level of scientific review because big manufacturers of personal care products don't use botanical ingredients, they use chemicals, because they are cheap ingredients. (thegoodhuman.com)
  • Many, many personal care products are deceptively labeled as "organic" while they are not… they may have some organic ingredients but they are not organic and for me personally this is a big issue. (thegoodhuman.com)
  • this is the food standard, which at this time is the only standard for personal care products. (thegoodhuman.com)
  • Great stuff Erin, thanks for taking the time to let us know about other places to check for personal care products! (thegoodhuman.com)
  • Just how safe are the personal care products you use every day? (futurity.org)
  • Barrett and Llanos, researchers at Rutgers University's School of Public Health, are studying how chemicals in the personal care products we use every day-from soap and shampoo to perfume and body lotions-may adversely affect our health . (futurity.org)
  • What has your research found about the risks chemicals in personal care products present? (futurity.org)
  • When we think about the health risks posed by personal care products, skin irritation or rashes are often the first things that come to mind, but there also may be "invisible" long-term health impacts from many of the chemicals contained in personal care products, which are known endocrine disruptors, carcinogens and developmental toxicants. (futurity.org)
  • The findings from that study warrant further study to explore hair products and other personal care products as important exposures contributing to risk of breast cancer. (futurity.org)
  • In addition to our research, several other studies have suggested potential links between the use of personal care products, which might contain harmful ingredients, and increased risks for various conditions. (futurity.org)
  • Currently, we are conducting a survey among members of the Rutgers community that will collect information on the products used as well as how people perceive their personal care products and how they select the products they use. (futurity.org)
  • How can people select more safe personal care products? (futurity.org)
  • Gerry Stimson, Chair of the NNA stated, 'Snus is a tobacco product that has consistently been proven to be less harmful to health than cigarettes. (eurekalert.org)
  • Additionally, a previous version of these guidelines states: "Where local circumstances require that a choice must be made between meeting either microbiological guidelines or guidelines for disinfectants or disinfectant by-products, the microbiological quality must always take precedence, and where necessary, a chemical guideline value can be adopted corresponding to a higher level of risk. (cdc.gov)
  • Another trend gathering popularity is consumers wanting health focused, holistic products (which are often also organic) in their lives. (nuskin.com)
  • In fact, more organic and/or "all natural" products and cosmetic lines are entering the market at a very rapid rate. (nuskin.com)
  • Merv 8 Furnace Filter 4 Pack of 20 Inch by 14 Inch by 1 Inch Duo Filters This is a package of 4 Safe Home(TM) Duo furnace filters for both allergens and volatile organic compounds such as. (safehomeproducts.com)
  • Disposable Duo Layered Furnace Filters This is a package of 4 Safe Home(TM) Duo furnace filters for both allergens and volatile organic compounds such. (safehomeproducts.com)
  • When I buy a personal care product if it has the word "organic" on it, I want it to be truly organic. (thegoodhuman.com)
  • If the label says certified organic, then the body care product is food standard organic). (thegoodhuman.com)
  • So, with that in mind use products with glycolic acid (made from sugar cane), most moisturizers and cleansers (organic probably even better), suncreens with zinc (a natural mineral), mineral make-ups, organic body lotions (try Eminence Honeydew or Mimosa - SkinTour.com), light exfoliants (try the Dermatologica made with rice powder - SkinTour.com). (skintour.com)
  • He says this is more to cut off state ballot initiatives popping up across the country, which are invariably hijacked by homeopaths, alternative medicine gurus and the $29 billion organic industry to claim a facade of 'food awareness' but really are just warning labels for competitive products. (science20.com)
  • Blogger and founder of Viva Woman, Sesame is a skin care addict who is fond of using natural & organic beauty products. (vivawoman.net)
  • Many people use so-called feminine hygiene products - such as intimate cleansers and wipes, douches, and even deodorants - hoping to feel clean and fresh. (medicalnewstoday.com)
  • So-called feminine hygiene products - which include different types of intimate washes, wipes, shaving gels, and lubricants, but also intimate douches and products for alternative care procedures, such as vaginal steaming - are popular in many countries around the world. (medicalnewstoday.com)
  • My favorite product on the website are the Biodegradable Wipes. (ecochildsplay.com)
  • These are great to carry in handbags, diaper bags, the glove box, etc… The company carries a select few products (like these wipes) which are produced by other companies and filled a needed niche). (ecochildsplay.com)
  • While the US Food and Drug Administration (FDA) may be primarily concerned with what medicinal products do to the human body, a lesser-known secondary concern of regulators is what a product will do to the environment. (raps.org)
  • From April 2011 an EU directive requires herbal medicinal products to be licensed, or to get Traditional Herbal Registration (THR), which means the information with the product has been approved. (highlighthealth.com)
  • David Ferguson, MicroCare product manager for precision cleaners, notes that most end users do not understand toxicity ratings, as they relate to their application. (pfonline.com)
  • In fact the original 13 products were specifically formulated to contain not only skin ingredients known to be beneficial to skin, but also to omit any ingredients that could potentially cause harm to the skin. (nuskin.com)
  • Roundup herbicide) now threaten human and environmental health alike, have moved beyond the stage of simply denying or minimizing the science revealing the harm being done by their products (there is too much science now to maintain this strategy! (greenmedinfo.com)
  • It shifts away from evaluating chemicals after they're already being used by consumers or already being disposed of, and moves toward evaluating potential hazards when a product is in development, before the harm is done. (cawrecycles.org)
  • These tests include, for example, skin irritation, patch testing to ensure the product does not cause allergic reactions and ocular irritation to ensure the product does not cause any eye irritation if the product is applied to the face. (nuskin.com)
  • The general advice for people with dark patches is to choose products that include active soy, or those free from lecithin, phosphatidylcholine, and textured vegetable protein. (medicalnewstoday.com)
  • Our bloggers include Safe Kids staff, parents, healthcare professionals, and others interested in raising awareness of preventable childhood injuries. (safekids.org)
  • Exclusions may include, but are not limited to, shipping options, products of certain size, weight, manufacturer price restrictions or products with savings/discounts already applied. (allegromedical.com)
  • Although the product labels include an NDC number and barcode, both amber vials have the same pattern of red and white on the labels along with plain aluminum ferrules ( Figure 1 ), which could contribute to a dangerous mix-up. (ismp.org)
  • Other products being introduced by Gentex at this year's SAFE Symposium include the Gentex Mini Dynamic Oxygen Mask Microphone (MDMM), developed to replace the existing Gentex M-169/AIC Oxygen Mask Microphone. (gentexcorp.com)
  • The company's comprehensive portfolio of Gentex, ALPHA, and Aegisound products include scalable helmet systems, and advanced hearing protection and communication solutions. (gentexcorp.com)
  • In addition, our commitment extends beyond the product portfolios to include service innovations being realized with future-thinking connectivity that are transforming hearing healthcare. (mpo-mag.com)
  • Are USG calcium sulfate products safe for food applications? (usg.com)
  • USG food and pharmaceutical grade calcium sulfate filler products conform to FDA Regulation 21CFR184.1230, and are affirmed as GRAS (Generally Regarded as Safe). (usg.com)
  • Calcium sulfate filler products are also safe to use in food packaging applications. (usg.com)
  • For example, the strength per mL is sometimes the most prominent expression on the principal display panel of an outsourcing facility's product label, rather than the strength per total volume (followed by the per mL amount in parentheses), as required by USP and the US Food and Drug Administration (FDA) for commercial manufacturers. (ismp.org)
  • The products were purchased from two well-known health food stores, three large-chain pharmacies and three supermarket pharmacies. (highlighthealth.com)
  • These cases highlight significant room for improvement when it comes to safe food handling. (provisioneronline.com)
  • Kansas Republican Mike Pompeo, a Congressman from Wichita, is behind a bill to create a national standard for mandatory for review of GMO foods by the FDA, called the"Safe and Accurate Food Labeling Act. (science20.com)
  • The United States Statute established the Health and Human Services Office of International Relations and a U.S. Food and Drug Administration office for regulatory activities concerning healthcare products which are considered a combinational biological, device, or drug product. (wikipedia.org)
  • Customers work directly with the designers in our labs to test and continually improve the usability of new products. (xerox.com)
  • As a result, current products have achieved chemical emission levels that are well below global regulatory requirements - often at or near the detection limit of our measurement equipment - and are considered to have a negligible impact on customers' work environments. (xerox.com)
  • How long will it take for the product to work? (avma.org)
  • As a charity, SAFE is reliant on the support of caring people like you to carry out our valuable work. (safe.org.nz)
  • So I have decided to do a quick summary of eyelash growth products available and note whether the ingredients are safe and whether they really work. (truthinaging.com)
  • I gather that henna may be safer, but does it work without brassy orange tones? (cancer.org)
  • Would this product work for me? (restore-a-deck.com)
  • The January 2012 settlement stemmed from complaints from hair stylists and customers that the product was causing symptoms, including nose bleeds, burning eyes and throat, skin irritation, and asthma attacks. (calaborfed.org)