AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Rosette FormationImmune Adherence ReactionErythrocytesReceptors, FcReceptors, ComplementImmunoglobulin Fc FragmentsLymphocytesReceptors, Antigen, B-CellLeukemia, LymphoidT-LymphocytesComplement C3Immunologic TechniquesReceptors, Complement 3bBinding Sites, AntibodyAntilymphocyte SerumSheepB-LymphocytesImmunoglobulin GComplement System ProteinsDinitrochlorobenzeneCytochalasin BImmunoglobulin MBlood Group AntigensComplement C3bLeukocyte CountPlasmodium falciparumAntigen-Antibody ComplexAntibodies, MonoclonalMonocytesAntigen-Antibody ReactionsImmune SeraPhagocytosisMalaria, FalciparumCell AdhesionSpleenTrypsinLectinsAntigens, SurfaceGuinea PigsCell SeparationLymphocyte ActivationEpitopesFluorescent Antibody TechniqueThymus GlandReceptors, IgGCytotoxicity Tests, ImmunologicReceptors, ImmunologicLymphomaMicroscopy, ElectronBinding, CompetitiveMacrophagesCells, CulturedCell MembraneCell LineNeutrophilsRabbits
Rosette Formation: The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.Immune Adherence Reaction: A method for the detection of very small quantities of antibody in which the antigen-antibody-complement complex adheres to indicator cells, usually primate erythrocytes or nonprimate blood platelets. The reaction is dependent on the number of bound C3 molecules on the C3b receptor sites of the indicator cell.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Receptors, Fc: Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.Receptors, Complement: Molecules on the surface of some B-lymphocytes and macrophages, that recognize and combine with the C3b, C3d, C1q, and C4b components of complement.Immunoglobulin Fc Fragments: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Receptors, Antigen, B-Cell: IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.Leukemia, Lymphoid: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Complement C3: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.Immunologic Techniques: Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.Receptors, Complement 3b: Molecular sites on or in some B-lymphocytes and macrophages that recognize and combine with COMPLEMENT C3B. The primary structure of these receptors reveal that they contain transmembrane and cytoplasmic domains, with their extracellular portion composed entirely of thirty short consensus repeats each having 60 to 70 amino acids.Binding Sites, Antibody: Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.Antilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Complement C3b: The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Plasmodium falciparum: A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.Cell Adhesion: Adherence of cells to surfaces or to other cells.Spleen: An encapsulated lymphatic organ through which venous blood filters.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Cell SeparationLymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Epitopes: Sites on an antigen that interact with specific antibodies.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Thymus Gland: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Cytotoxicity Tests, Immunologic: The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.Receptors, Immunologic: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Establishment of an activated macrophage cell line, A-THP-1, and its properties. (1/1162)

A new macrophage cell line with activated character and unique morphology was isolated by selecting adherent cells from the human monocytic cell line THP-1. The original THP-1 cells had been cultured for more than 9 years using 25 cm2 flasks, when cells with a different morphology appeared, adhering to the bottoms of the culture flasks. These were selected by discarding floating nonadherent cells at every subculture. Enrichment of adherent THP-1 cells with long processes proceeded during the cultivation. These adherent THP-1 showed remarkable phenotypic changes, not only morphologically, but also functionally. Namely, increased phagocytic activity, HLA-DR expression and MLR stimulator activity were remarkable. This adherent cell line was designated as activated-THP-1 (A-THP-1), since it demonstrated characteristics of activated macrophages continuously without exogenous stimulation. A cloned A-THP-1 cell line (A-THP-1 C1) also showed the same features and contained about 10% multinucleated giant cells probably caused by cell fusion. This A-THP-1 cell line, the first activated macrophage cell line to be established, provides a good model for understanding of activation mechanisms of macrophages and multinucleation. In this paper, morphological, immunological, and biological characters of this cell line are described.  (+info)

Protein kinase C and a calcium-independent phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells. (2/1162)

Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythrocytes (EIgG) in a calcium-independent manner. Incubation of MM6 with bromoenol lactone, an inhibitor of the phagocytic phospholipase (pPL), coordinately decreased phagocytosis and pPL activity. This inhibition was overcome by exogenous arachidonic acid, suggesting that phagocytosis requires pPL activation and arachidonic acid release. MM6 phagocytosis was inhibited with staurosporine and activated with diacylglycerol, supporting a role for protein kinase C (PKC) in this process. The pPL activators mastoparan and melittin restored phagocytosis to PKC-inhibited cells, suggesting that pPL lies downstream from PKC. These results suggest that the MM6 signal transduction pathway for IgG-mediated phagocytosis is similar to that of monocytes (PKC-->pPL-->arachidonic acid-->phagocytosis). The results are discussed in the context of the finding that MM6 exhibit low phagocytosis relative to monocytes and thus may represent an attractive cell line for molecular manipulation in "recovery of function" studies.  (+info)

Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89. (3/1162)

Cellular receptors for IgA (FcalphaR) mediate important protective functions. An extensive panel of site-directed mutant IgAs was used to identify IgA residues critical for FcalphaR (CD89) binding and triggering. Although a tailpiece-deleted IgA1 was able to bind and trigger CD89, antibodies featuring CH3 domain exchanges between human IgA1 and IgG1 could not, indicating that both domains but not the tailpiece are required for FcalphaR recognition. To further investigate the role of the interdomain region, numerous IgA1s, each with a point substitution in either of two interdomain loops (Leu-257-Gly-259 in Calpha2; Pro-440-Phe-443 in Calpha3), were generated. With only one exception (G259R), substitutions produced either ablation (L257R, P440A, A442R, F443R) or marked reduction (P440R) in CD89 binding and triggering. Further support for involvement of these interdomain loops was provided by interspecies comparisons of IgA. Thus a human IgA1 mutant, LA441-442MN, which mimicked the mouse IgA loop sequence through substitution of two adjacent residues in the Calpha3 loop, was found, like mouse IgA, not to bind CD89. In contrast, bovine IgA1, identical to human IgA1 within these interdomain loops despite numerous differences elsewhere in the Fc region, did bind CD89. We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction.  (+info)

Plasmodium falciparum malaria: rosettes are disrupted by quinine, artemisinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. (4/1162)

An assay was developed measuring the disruption of rosettes between Plasmodium falciparuminfected (trophozoites) and uninfected erythrocytes by the antimalarial drugs quinine, artemisinin mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. At 4 hr incubation rosettes were disrupted by all the drugs in a dose dependent manner. Artemisinin and quinine were the most effective anti-malarials at disrupting rosettes at their therapeutic concentrations with South African RSA 14, 15, 17 and The Gambian FCR-3 P. falciparum strains. The least effective drugs were proguanil and chloroquine. A combination of artemisinin and mefloquine was more effective than each drug alone. The combinations of pyrimethamine or primaquine, with quinine disrupted more rosettes than quinine alone. Quinine may be an effective drug in the treatment of severe malaria because the drug efficiently reduces the number of rosettes.  (+info)

Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. (5/1162)

Cytoadherence of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium is believed to be a key factor in the development of cerebral malaria. Erythrocyte rosette formation has been correlated with malaria severity in studies from east and west Africa. We cultured fresh isolates from Malawian children with severe (n = 76) or uncomplicated (n = 79) malaria to pigmented trophozoite stage and examined rosette formation and adherence to CD36, intercellular adhesion molecule-1 (ICAM-1), chondroitin sulfate A (CSA), and thrombomodulin (TM). Most (126 of 148) isolates bound to CD36, and 76 of 136 bound to ICAM-1. Fewer bound to CSA (40 of 148) or TM (23 of 148). After controlling for parasitemia, there was an inverse association between binding to CD36 (P = 0.004) or ICAM-1 (P = 0.001) and disease severity. Parasites from children with severe malaria anemia bound least to CD36, whereas ICAM-1 binding was lowest in children with cerebral malaria. There was no difference in rosette formation between any of the groups. In Malawian children, there was no evidence of a positive association between adherence to any of the receptors examined and disease severity. The negative association found raises the possibility that adherence to certain receptors could instead be an indicator of a less pathogenic infection.  (+info)

In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. (6/1162)

Immune evasion is critical for survival of viruses that establish persistent or recurrent infections. However, at the molecular level, little is known about how viruses evade immune attack in vivo. Herpes simplex virus (HSV)-1 glycoprotein gC has two domains that are involved in modulating complement activation; one binds C3, and the other is required for blocking C5 and properdin (P) binding to C3. To evaluate the importance of these regions in vivo, HSV-1 gC mutant viruses were constructed that lacked one or both gC domains and studied in a murine model of infection. Each gC region of complement regulation contributed to virulence; however, the C3 binding domain was far more important, as virus lacking this domain was much less virulent than virus lacking the C5/P inhibitory domain and was as attenuated as virus lacking both domains. Studies in C3 knockout mice and mice reconstituted with C3 confirmed that the gC domains are inhibitors of complement activation, accounting for a 50-fold difference in virulence between mutant and wild-type viruses. We conclude that the C3 binding domain on gC is a major contributor to immune evasion and that this site explains at a molecular level why wild-type virus resists complement attack.  (+info)

Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women. (7/1162)

We examined the formation of Plasmodium falciparum erythrocyte rosettes using parasite isolates from placental or peripheral blood of pregnant Malawian women and from peripheral blood of children. Five of 23 placental isolates, 23 of 38 maternal peripheral isolates, and 136 of 139 child peripheral isolates formed rosettes. Placental isolates formed fewer rosettes than maternal isolates (range, 0 to 7. 5% versus 0 to 33.5%; P = 0.002), and both formed fewer rosettes than isolates cultured from children (range, 0 to 56%; P < 0.0001). Rosette formation is common in infections of children but uncommon in pregnancy and rarely detected in placental isolates.  (+info)

Autologous T cells control B-chronic lymphocytic leukemia tumor progression in human-->mouse radiation chimera. (8/1162)

B-chronic lymphocytic leukemia (B-CLL) is characterized by the clonal accumulation of CD5+ B cells. It has been suggested that CLL cells may be regulated by inhibitory and growth-promoting signals exerted by autologous T cells. We have recently described a model for human B-CLL in which peripheral blood mononuclear cells (PBMCs) are transplanted into the peritoneal cavity of lethally irradiated mice radioprotected with bone marrow from mice with severe combined immunodeficiency. In this model, adoptive transfer of low-stage PBMCs leads to marked engraftment of T cells or combined T and CLL cell engraftment, whereas infusion of high-stage PBMCs leads to dominance of CLL cells with a miniscule level of T-cell engraftment. This mutual exclusive pattern of engraftment indicated that T cells might control the expansion of tumor cells in the peritoneum of recipient BALB/c mice. In the present study, we further investigated this question and we demonstrate that in vivo T-cell depletion, using OKT3 antibody, markedly enhances the engraftment of B-CLL cells from patients with early-stage disease. In mice receiving PBMCs from 11 donors with advanced-stage disease, the results were more heterogeneous. In five patients the results were similar to those observed in early stage, whereas in two cases no CLL cell engraftment was found in the absence of T cells. The addition of purified T cells to PBMCs led to a substantial decrease of CLL engraftment in three advanced-stage cases. These results strengthen the working hypothesis that autologous T cells can actively suppress the expansion of the pathological cells in human-->mouse radiation chimera. This effect is prominent in early-stage disease, whereas in advanced stage suppressive and/or stimulatory effects may occur in different patients. The interaction of T cells with tumor cells and the potential of autologous T cell/immune-therapy in CLL can be further explored in this model.  (+info)

Plasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α - pdf descargarPlasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α - pdf descargar
Plasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Rosette formation by mouse lymphocytes. II. T-cell specificities in by villena A. Arnaiz, M I. Gyongyossy et al."Rosette formation by mouse lymphocytes. II. T-cell specificities in " by villena A. Arnaiz, M I. Gyongyossy et al.
Arnaiz, villena A.; Gyongyossy, M I.; and Playfair, J H., "Rosette formation by mouse lymphocytes. II. T-cell specificities in a crl subpopulation." (1974). Subject Strain Bibliography 1974. 572 ...
Alveolar macrophage-lymphocyte rosette formation: failure of l...Alveolar macrophage-lymphocyte rosette formation: failure of l...
Alveolar macrophage-lymphocyte rosette formation: failure of levamisole to alter activity.: Levamisole, an anthelminthic agent with immunostimulatory properties
Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58 - Research...Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58 - Research...
A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ T cells that surround, protect and promote survival of tumor cells. The adhesion molecules involved in this so-called T cell rosetting are important components of the immunological synapse (IS). However, it is unknown whether this synapse is fully assembled and leads to T cell activation by enabling interaction between the T cell receptor (TCR) and human leukocyte antigen class II (HLA-II). We established a novel rosetting model by co-culturing HLA-II matched PBMCs with HL cell lines and show IS formation with activation of rosetting T cells. HLA-II downregulation by CIITA-knockout did not affect the extent of rosetting, but almost completely abrogated T cell activation. Intriguingly, the level of CD58 expression correlated with the extent of rosette formation and CD58-knockout or CD2 blockade reduced both rosette formation and T cell activation. Extension of our findings to primary HL tissue by immunohistochemistry and proximity ...
The roles and regulation of multicellular rosette structures during morphogenesis | DevelopmentThe roles and regulation of multicellular rosette structures during morphogenesis | Development
The rosettes that form during compound eye development evolve from nine- to ten-cell-wide lines of cells (Fig. 4) (Brown et al., 2006; Escudero et al., 2007; Robertson et al., 2012). These lines evolve into arcs, which are composed of six to seven cells surrounding the core cells that are eventually excluded from the rosette. Each arc then zips up into a rosette conformation, which initially contains up to seven cells joined at a central vertex (Fig. 4). During this period, markers of neuronal maturation are detectable in presumptive photoreceptors (Brown et al., 2006). Over time, core cells are excluded, progressively giving rise to a six-cell intermediate and then a five-cell rosette (Robertson et al., 2012).. In the absence of three-dimensional reconstruction studies, it is difficult to determine whether rosette formation in the Drosophila eye is based on apical or planar polarized constriction, although the localization of Par-3 and myosin-II to reciprocal domains prior to rosette ...
Detection and characterization of lymphocytes bearing receptors for pe by S Berrih, J London et al."Detection and characterization of lymphocytes bearing receptors for pe" by S Berrih, J London et al.
Berrih, S; London, J; Bonavida, B; and Bach, J F., "Detection and characterization of lymphocytes bearing receptors for peanut agglutinin by a specific rosetting technique." (1981). Subject Strain Bibliography 1981. 1339 ...
Chapter 2.2Chapter 2.2
So that, by color-symmetry desymmetrizations of the symmetry groups of rosettes, it is possible to obtain exclusively symmetry groups of the type Cn (n). Group-subgroup relations can also serve as an indicator of the frequency of occurrence of certain rosettes in ornamental art, in line with the tendency toward maximal visual simplicity and symmetry. The full expression of the principle of visual entropy is the very frequent use of circles - visual models of the maximal continuous symmetry group of rosettes D ( m). The same is a reason for the domination of the dihedral symmetry groups of rosettes Dn (nm) over the corresponding cyclic groups Cn (n), resulting from the relationship [Dn:Cn] = 2. The priority of rosettes with the symmetry group D2n (2nm) over rosettes with the symmetry group Dn (nm), or rosettes with the symmetry group C2n (2n) over rosettes with the symmetry group Cn (n) ( [D2n:Dn] = 2, [ C2n:Cn] = 2 ), may be reduced to the question of the existence of a central reflection as the ...
The plasma membrane of ox erythrocytes as studied by wheatstone bridge measurements | SpringerLinkThe plasma membrane of ox erythrocytes as studied by wheatstone bridge measurements | SpringerLink
Mc Clendon, J. F., Colloidal Properties of the surface of the living cell. Colloid Symposium monograph. Chem. Cat. Co. 4: 224 (1926).Google Scholar ...
Rosette Formation by Plasmodium Coatneyi-Infected Red Blood Cells | The American Journal of Tropical Medicine and HygieneRosette Formation by Plasmodium Coatneyi-Infected Red Blood Cells | The American Journal of Tropical Medicine and Hygiene
Abstract Animal models are needed for the study of cytoadherence in falciparum malaria. Red blood cell (RBC) rosette formation is one type of cytoadherence and appears to be associated with knob formation, endothelial cell adhesion and sequestration of Plasmodium-infected RBCs. Since Plasmodium coatneyi-infected RBCs develop knobs and sequester, we hypothesized that they also form rosettes. RBCs from P. coatneyi-infected rhesus monkeys (Macaca-mulatta) were collected, allowed to mature overnight in vitro and found to form rosettes as hypothesized. This observation adds to the known falciparum-like characteristics of P. coatneyi, and suggests that the Macaca mulatta-P. coatneyi model may be appropriate for pathophysiologic studies of cytoadherence.
The American Journal of Tropical Medicine and Hygiene | The time course of cytoadhesion, immunoglobulin binding, rosette...The American Journal of Tropical Medicine and Hygiene | The time course of cytoadhesion, immunoglobulin binding, rosette...
We describe morphologic characteristics of acridine orange-stained Plasmodium falciparum-infected erythrocytes and the sequential expression of several adhesion phenomena. In particular, we have studied when the adhesive and antigenic modifications appear on the infected erythrocyte surface that mediate binding to C32 melanoma cells (cytoadherence) or to erythrocytes (rosette formation) during a complete 48-hr life cycle of the parasite. The C32 melanoma cell binding started at about 12 hr and was seen during the whole life cycle with a peak around 28 hr (650 infected erythrocytes/100 C32 melanoma cells). Rosettes started to appear and immunoglobulin was found bound to the parasitized red blood cell (PRBC) somewhat later (16-20 hr). These adhesive events culminated at the mid-trophozoite/schizont stage (24-36 hr) with rosette formation and an immunoglobulin binding rate of about 50%, which decreased to about half of the peak values at the end of the life cycle. Serum-induced agglutination of the
UM Students RepositoryUM Students' Repository
Rosette formation is one of the unique biological phenomena that have been linked to pathobiology of malaria. It is believe to be associated with the severe outcomes of falciparum malaria. Most of the knowledge about rosetting is obtained from in-depth studies conducted on Plasmodium falciparum. However, the rosetting phenomenon and pathobiology of vivax malaria is not well studied. This research project aimed at deciphering the unknown aspects behind rosetting phenomenon of P. vivax, and investigating the role of rosette formation in pathobiology of vivax malaria. In total, 121 fresh P. vivax isolates, 48 cryopreserved P. vivax isolates, 122 fresh P. falciparum isolates and 5 cryopreserved P. falciparum isolates were recruited into this research project. A novel technique suitable for reticulocyte characterization and rosetting assay in field setting was developed from this research project. Based on the field studies conducted, rosette formation is common in P. vivax. However, rosetting is not ...
Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies - Wellcome Centre for...Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies - Wellcome Centre for...
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Ultrastructural study of spontaneous bone marrow rosette-forming cells.Ultrastructural study of spontaneous bone marrow rosette-forming cells.
Mouse bone marrow contains spontaneous rosette-forming cells (RFC) which include more than 70% T-cell precursors, as assessed by their transformation into theta-positive cells after incubation with thymic hormone. Such spontaneous RFC, examined in C5
Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human...Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human...
A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0.18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0.5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD.
Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors...Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors...
Increased numbers of eosinophilic granulocytes that exhibit an activated phenotype are found in bronchial tissue and bronchial alveolar lavage fluid of patients with allergic asthma. Little is known about the processes that lead to activation of eosinophils in vivo, but Igs might be important stimulants. In the present study we investigated the capacity of human eosinophils to interact with beads coated with human serum IgG or IgA. Binding of IgG/IgA-coated beads to eosinophils from normal donors appeared to be dependent on priming with Th2-derived cytokines. Priming with granulocyte-macrophage CSF, IL-4, or IL-5 is required for eosinophils to form rosettes with IgA-beads. IL-4 priming resulted in a fast and transient effect on binding of IgA-beads, whereas the effect of IL-5 priming was slower and longer lasting. The expression of Fc alphaR (CD89) was low compared with that on neutrophils, and experiments with the blocking mAb My43 (CD89) showed no inhibition of rosette formation between ...
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We studied the ability of lymphocytes from type I (insulin-dependent) diabetic patients to adhere to murine β-cells. Lymphocytes from 17 recent-onset type I diabetic subjects (,6 mo) displayed enhanced ability to form rosettes with RINm5F cells (P , .001) compared with lymphocytes from 27 healthy subjects forming background rosettes, whereas the number of RIN cytoadherent lymphocytes was unimpaired in 12 type II (non-insulin-dependent) diabetic subjects. This phenomenon tended to decline in 21 subjects with long-standing diabetes (,1 yr) who taken as a group presented a normal number of RIN rosetting lymphocytes. The islet specificity of these diabetic rosettes was confirmed because, compared with controls, lymphocytes from recent-onset type I diabetic subjects also displayed a greater intensity of adherence to normal mouse islets but not to unrelated K562 and TS cell lines. As demonstrated by indirect immunofluorescence studies, these diabetic rosettes contained 54% of T-lymphocytes (OKT3+, ...
Rosette Aqua Ceramide Gel | ReviewRosette Aqua Ceramide Gel | Review
First of all I would like to start with the appearance of the product. The jar looks awesome! White colored tub packaging looks very minimalist and futuristic. With the product you also get a little plastic spatula which helps you keep your product uncontaminated for a little longer.. Texture of a moisturizer is white and gel-ish. It has a typical non-scented chemical smell which I like. I apply the gel after I washed, toned and nourished my skin with serums and essences. When I patted it into my skin it absorbed really quickly (5-8 min).. The other day I put it on way more and it needed longer time to absorb, and that day I skipped serums and essences, because it claims that it can provide five basic skincare elements: Lotion, Beauty Serum, Emulsion, Cream, and Mask.. ...
CNALH - Protoparmeliopsis garovagliiCNALH - Protoparmeliopsis garovaglii
Thallus: placodioid, 4-6 cm or more in diam., 0.5-2(-3) mm thick in center, distinctly rosetted, but often confluent, tightly to usually +loosely adherent; rimose-areolate to verrucose-areolate or bullate-areolate in center; prothallus: vestigial, the lobe tips and occasionally edges frequently dark olivaceous to bluish black areoles: contiguous, irregular in outline, 0.3-1.5 mm across, convex to irregularly depressed lobes: 4-8 mm long, 0.5-1.5 mm wide, to c. 1 mm thick, +contiguous, usually +distinct to the thallus center, plane to +strongly but irregularly convex and swollen, sinuous, weakly to strongly plicate, furrowed along the center, or irregularly foveolate, crenate-incised towards tips, the ultimate segments 0.3-0.7 mm wide; tips dilated, often recurved upper surface: +dull, spottily to densely pruinose; continuous to rather strongly rimose; pale, moderate, or grayish greenish yellow, pale or grayish yellowish green, light to moderate or grayish yellow, in herbarium pale yellow, pale ...
Bearing FC6284300/YA3Bearing FC6284300/YA3
Surface Treatment:No; Seal:Nitrile; Unit, Type:Insert Bearing Unit; Bearing Inner Dia. Shape:Cylindrical Bore Set; Basic Load Rating, Static Rating(N):40100; RoHS:6; Basic Load Rating, Dynamic Rating(N):57200; Rolling Element Material:Bearing Steel; d:65; Bearing Inner Dia. Shape:Cylindrical Bore Set ...
How To Make Tissue Flowers | Crepe paper, Crepes and RosettesHow To Make Tissue Flowers | Crepe paper, Crepes and Rosettes
Follow this easy tutorial and learn how to make tissue flowers. Then use those flowers to make some fun kissing balls. Great idea for wedding and home decor.
Osmolarity was restored and a culture containing 30% lysed uninfected erythrocytes and 70% intact uninfected erythrocytes - ...Osmolarity was restored and a culture containing 30% lysed uninfected erythrocytes and 70% intact uninfected erythrocytes - ...
Our reports show Osmolarity was restored and a culture containing 30% lysed uninfected erythrocytes and 70% intact uninfected erythrocytes clearly that directional flight action and time compensated sunshine compass orientation persist reproductively active Osmolarity was restored and a culture containing 30% lysed uninfected erythrocytes and 70% intact uninfected erythrocytes migrants, but persistent time compensation experienced not been revealed earlier. It is Osmolarity was restored and a culture containing 30% lysed uninfected erythrocytes and 70% intact uninfected erythrocytes nonetheless feasible that JH deficiency is involved in the induction of directed flight for sun compass orientation, but it is distinct from our results that persistent JH deficiency is not required for upkeep. More analysis of the forty genes we have discovered in monarchs will very likely offer novel insights into their personal and or collective significance for migration and the brain alterations needed to ...
Plasmodium falciparum Rosette Formation Assay -BIO-PROTOCOLPlasmodium falciparum Rosette Formation Assay -BIO-PROTOCOL
Rosetting, i.e. the capacity of red blood cells (iRBCs) infected with mature parasite stages to bind two or more uninfected red blood cells (RBCs) is a virulence factor of Plasmodium falciparum. This protocol describes an in vitro assay to monitor rosette formation by P. falciparum-infected red blood cells, including procedures for rosette enrichment, maintenance of rosetting phenotype and assays for rosetting with RBC labeled using lipophilic fluorescent probes.
Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of...Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of...
TY - JOUR. T1 - Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of effector lymphocytes. AU - Perlmann, H.. AU - Perlmann, P.. AU - Moretta, L.. AU - Ronnholm, M.. PY - 1981. Y1 - 1981. N2 - IgM antibodies have previously been reported to either inhibit or induce antibody-dependent lymphocyte cytotoxicity (ADCC). Here the authors show that human lymphocytes lyse bovine erythrocytes (Eb) in the presence of either IgM or IgG anti-Eb from rabbits. Seven out of 20 IgM preparations (Sephadex G-200) were ADCC-active. IgG-dependent ADCC was inhibited by human IgG but not by IgM. In contrast, IgM ADCC was inhibited by both IgG and IgM. The effector cells in IgM ADCC were a subpopulation of lymphocytes with distinct Fc receptors for both IgG and IgM. Most of them also had sheep erythrocyte receptors. Extensive purification of the ADCC-active IgM antibody preparations indicated that very small amounts of contaminating IgG anti-Eb were ...
STUDIES ON ANTIBODY-PRODUCING CELLS | JEMSTUDIES ON ANTIBODY-PRODUCING CELLS | JEM
Antibody-bearing cells of spleen and lymph node of the mouse and rabbit detected by rosette formation with the antigenic red blood cells were collected by micropipet and studied by electron microscopy. More than 300 such cells were examined. In the lymph nodes, rosette-forming cells were all in the lymphocytic and plasmacytic categories. In cells of the mouse spleen, macrophages were also found among the RFC, especially in the later days after immunization.. The great majority of the RFC, 70-100%, were of the lymphocytic category. These included small, medium, and large lymphocytes with fine gradations of differentiation, and blast forms with little heterochromatin. The endoplasmic reticulum of these cells occurred in short, very narrow pieces, usually in contact with a mitochondrion. The cells of the plasmacytic category also showed fine gradations from plasmablasts to typical mature plasma cells.. Plaque-forming cells of mouse and rabbit were also collected by micropipet. Of 162 such cells, ...
Rosetting - Parasitology - European Medical AllianceRosetting - Parasitology - European Medical Alliance
Rosetting refers to the adherence of uninfected erythrocytes to erythrocytes containing mature forms of some, but not all, isolates of P. falciparum. The phenomenon is observed when suspensions of parasitised cells are viewed under the microscope, and for some isolates depends on the blood group of the cells used for culture (Figure 3.5). The relevance of the in vitro findings is debated, as in some (Carlson et al., 1990), but ...
China Brass Rosette Lock Door Handle-Ba571 - China Brass Door Handle, Handle and PlateChina Brass Rosette Lock Door Handle-Ba571 - China Brass Door Handle, Handle and Plate
China Brass Rosette Lock Door Handle-Ba571, Find details about China Brass Door Handle, Handle and Plate from Brass Rosette Lock Door Handle-Ba571 - Wenzhou Tops Hardware Co., Ltd.
Rosetting FCR3S1.2-PfEMP1 binds to heparan sulfate. All | Open-iRosetting FCR3S1.2-PfEMP1 binds to heparan sulfate. All | Open-i
Rosetting FCR3S1.2-PfEMP1 binds to heparan sulfate. All the gels are 10% SDS-PAGE stained with Coomassie. A shows the expressed GST, DBL-1-GST, or ATS-GST
Lipid profiles in the rosettes of WT, ACBP3-OEs and ACB | Open-iLipid profiles in the rosettes of WT, ACBP3-OEs and ACB | Open-i
Lipid profiles in the rosettes of WT, ACBP3-OEs and ACBP3-KOs after LS treatment.(a) Content of lipid species of 4-week-old WT, ACBP3-OEs (OE-1 and OE-4) and AC
Abortiporus biennis - Blushing Rosette (Polyporale images)Abortiporus biennis - Blushing Rosette (Polyporale images)
APHOTOFUNGI - Photographic Stock Image Library Page for Abortiporus biennis - Blushing Rosette (Polyporale images). A-P-H-O-T-O - Furthering environmental awareness and education through the medium of photography.
Black Velvet Rosettes Headwrap/Choker | Ulta BeautyBlack Velvet Rosettes Headwrap/Choker | Ulta Beauty
Get all wrapped up in holiday style with a wreath of Black Velvet Rosettes that does double duty as a Headwrap or a choker from Scünci.
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The present study has documented the feasibility of our immunomagnetic assay for detecting micrometastatic cells in BM samples from CRC patients. In model experiments, a mean of 98% of the cells bound at least five beads to their surface in 11 of 12 CRC cell lines. Moreover, a consistently high recovery of target cells was achieved when different numbers of Co205 cells were mixed with 1 × 107 MNCs from BM and isolated with immunomagnetic beads, even when very small numbers of tumor cells were added. Furthermore, rosetted tumor cells were detected in 17% of BM samples obtained at primary surgery from 275 patients with CRC with a median of eight cells isolated per positive sample.. The overall frequency (17%) of positive samples from the CRC patients examined in the present study is lower than in many of the published reports using other methods. Thus, studies performed using immunocytochemical techniques report overall frequencies between 27 and 32% positive samples in population sizes of ...
Rosettes & CSSRosettes & CSS
Due to the latter, I think that is why Joomla continues to confuse me so. I have been open to learning it, as I know there will be a client who desires a Joomla site some day and I want to at least have some facts I can advise them on. Joomla has a method of its madness that I still to this day do not understand. I suppose to many people I speak to, "categories" and "sections" seem to feel like they are the same thing. This forum post shows a good example on how it confuses many not familiar with Joomlas "older cousin", Mambo. I was patient and found myself toiling over it in the last month trying to learn the interface. I cant lie and say that I wont get a client who insists on having a Joomla based website ...
Rosettes & CSSRosettes & CSS
Due to the latter, I think that is why Joomla continues to confuse me so. I have been open to learning it, as I know there will be a client who desires a Joomla site some day and I want to at least have some facts I can advise them on. Joomla has a method of its madness that I still to this day do not understand. I suppose to many people I speak to, "categories" and "sections" seem to feel like they are the same thing. This forum post shows a good example on how it confuses many not familiar with Joomlas "older cousin", Mambo. I was patient and found myself toiling over it in the last month trying to learn the interface. I cant lie and say that I wont get a client who insists on having a Joomla based website ...
Paramecium fusion rosettes: Possible function as Ca<sup>2+</sup>...Paramecium fusion rosettes: Possible function as Ca<sup>2+</sup>...
TY - JOUR. T1 - Paramecium fusion rosettes. T2 - Possible function as Ca2+ gates. AU - Satir, Birgit H.. AU - Oberg, Stephen G.. PY - 1978. Y1 - 1978. N2 - The function of a specific intramembrane particle array, "the fusion rosette," an essential requirement for exocytosis of trichocysts in Paramecium, was probed with a temperature sensitive secretory mutant (nd9). The cells were grown at 27°C, the nonpermissive, nonreleasing temperature at which fusion rosettes do not assemble. Exocytosis could be triggered, nonetheless, by addition of 40 μM ionophore A23187 and 15 mM Ca2+ but not Mg2+. Rosette function is bypassed by this procedure, suggesting that during normal release, the rosette acts as a Ca2+ channel that allows development of a site-specific increase in Ca2+, which in turn induces fusion and release.. AB - The function of a specific intramembrane particle array, "the fusion rosette," an essential requirement for exocytosis of trichocysts in Paramecium, was probed with a temperature ...
Nature of non-B, non-T lymphomas: an immunohistological study on frozen tissues using monoclonal antibodies. | Journal of...Nature of non-B, non-T lymphomas: an immunohistological study on frozen tissues using monoclonal antibodies. | Journal of...
In a previous study employing conventional immunological marker analysis we found that 17% of high grade malignant lymphomas were devoid of cytoplasmic and membrane immunoglobulin and also sheep erythrocyte receptors. Cryostat sections from 24 of these cases (four of low grade and 20 of high grade malignancy) were stained with a panel of 30 monoclonal antibodies and six polyclonal antisera using a sensitive immunoperoxidase method. All tumours expressed the leucocyte common antigen (detected by monoclonal antibody 2D1) and all lacked epithelial cytokeratin (monoclonal antibody LE61), confirming their haematopoietic origin. All but one of the lymphomas expressed antigens characteristic of either B cells (17 cases) or T cells (six cases), while one case (morphologically a centroblastic lymphoma) had an unusual dual phenotype in which strong staining for T6 (marker of immature T cells) was associated with expression of the pan B lymphocyte antigens detectable with To15, anti-B1, anti-Leu12. This ...
Surface markers and mitogen response of cells harvested from cutaneous infiltrates in mycosis fungoides and Sézarys syndrome. ...Surface markers and mitogen response of cells harvested from cutaneous infiltrates in mycosis fungoides and Sézary's syndrome. ...
It was the purpose of this study to characterize the proliferating cells in skin lesion of Sézarys syndrome and of mycosis fungoides by means of their surface markers and their response to Phytohemagglutinine mitogen stimulation. Viable infiltrating cells were freed from skin biopsy specimens by means of a disaggregating homogenizer and the cells yielded were tested with heterologius polyvalent anti-human Ig and with anti-human T-cell globulin, as well as for spontaneous rosette formation with sheep red blood cells (SRBC) and for their response to stimulation with Phytohemagglutinine. Most of the infiltrating cells in skin lesions of mycosis fungoides and Sézarys syndrome lack receptors for anti-human Ig but form spontaneous rosettes with SRBC and have receptors for anti-T-cell globulin, indicating the T-lymphocyte nature of the infiltrating cells; however, their response to Phytohemagglutinine is weak. The results indicate the atypical, presumably neoplastic, nature of T-lymphocytes proliferating
BINDING OF SOLUBLE IMMUNE COMPLEXES TO HUMAN LYMPHOBLASTOID CELLS | JEMBINDING OF SOLUBLE IMMUNE COMPLEXES TO HUMAN LYMPHOBLASTOID CELLS | JEM
In the present work we studied the expression of membrane-bound Ig (MBIg) as well as receptors for IgG Fc and complement on nine human lymphoblastoid cell lines. When MBIg and receptors for IgG Fc were compared, four categories of cell lines could be distinguished: (a) cell lines having both MBIg and receptors for IgG Fc, (b) cell lines having MBIg but lacking receptors for IgG Fc, (c) cell lines lacking MBIg but having receptors for IgG Fc, and (d) cell lines lacking both MBIg and receptors for IgG Fc. Two types of receptors for complement could be detected on the cell lines studied, one for C3-C3b and one for C3d. When sensitized red cells carrying C3b or C3d were used for rosette tests, three categories of cell lines could be distinguished: (a) cell lines having receptors for C3b and C3d, (b) cell lines having receptors only for C3d and (c) cell lines lacking both receptors. However, when a more sensitive immunofluorescent method was used instead of the rosette technique, it was found that ...
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Glucocorticoid receptor levels were quantitated in leukemic blasts from bone marrow aspirates of 174 children with acute lymphocytic leukemia. Using a whole-cell assay, we found that [3H]dexamethasone binding had the following characteristics: (a) reached a steady state in 30 min at 22° and was stable for at least 2 hr; (b) was linear with cell number between 1 and 6 × 106 cells/assay; (c) was higher in freshly prepared blasts compared to blasts stored for 18 hr at 4 or 22°; (d) was specific for glucocorticoids; (e) had a Kd of ≈1 × 10-8 m; and (f) required a postincubation washing step to maximize sensitivity and decrease nonspecific binding. Glucocorticoid receptor levels in patient samples exhibited a wide range from 2,248 to 79,364 sites/cell (median, 18,123). A lower level was correlated with the following biological and clinical characteristics at diagnosis: high leukocyte count; positive sheep erythrocyte rosette test; T-cell surface antigens; presence of mediastinal mass; age ,2 or ...
Rosette | FastEmojiRosette | FastEmoji
Rosette Rose,U+1F3F5,Cherry Blossom,Military Medal,Large Blue Circle,Diamond Shape With A Dot Inside,Fleur-De-Lis,Heart Decoration,Classical Building,Blossom,screw,tangle,nexus,twist,whorl,braid,bunch,whirl,spiral,snag,tie,warp,joint,snarl,yoke,splice,coil,hitch,kink,twirl,link,bond,helix,mat,gnarl,line,truelove knot,lovers knot,red,connection,contortion,entanglement,ligament,ligature,perplexity,rosette,vinculum,badge of loyalty,true lovers knot,blush,flush,pink,rouge,knot,love knot,rose,Rosétte,Rosette,cunt,flap,jodie,rosétta,brownlow,badge,ornament,medal of honor,lucifer,rorieea,flossy,tillie,creepyspice,jeff,arielxtriton,trixie nightshock,red,pink,blush,burn,color,color up,crimson,flame,glow,go red,mantle,pinken,redden,rose,rouge,suffuse,be suffused,blare,blaze,brighten,fill,flare,flush,gleam,glimmer,glisten,glitter,ignite,kindle,light,shine,smolder,thrill,tingle,twinkle,coral,fuchsia,roseate,salmon,bittersweet,bloodshot,blooming,brick,burgundy,cardinal,carmine,cerise,cherry,chestnut,claret
Protein A-coated erythrocyte binding to cell surface antigens: Application to quantitate retrovirus infectivity in vitro<...Protein A-coated erythrocyte binding to cell surface antigens: Application to quantitate retrovirus infectivity in vitro<...
TY - JOUR. T1 - Protein A-coated erythrocyte binding to cell surface antigens. T2 - Application to quantitate retrovirus infectivity in vitro. AU - Fitting, Thomas. AU - Kabat, David. PY - 1981/6. Y1 - 1981/6. N2 - Fibroblasts infected with murine leukemia virus (MuLV) bind erythrocytes coated with protein A to form rosettes in the presence of MuLV-specific antisera. This method, which is potentially applicable to any retrovirus and susceptible cell, has been specifically adapted as a focus assay for quantitating both ecotropic and xenotropic MuLV.. AB - Fibroblasts infected with murine leukemia virus (MuLV) bind erythrocytes coated with protein A to form rosettes in the presence of MuLV-specific antisera. This method, which is potentially applicable to any retrovirus and susceptible cell, has been specifically adapted as a focus assay for quantitating both ecotropic and xenotropic MuLV.. UR - http://www.scopus.com/inward/record.url?scp=0019472752&partnerID=8YFLogxK. UR - ...
Pineocytoma - WikipediaPineocytoma - Wikipedia
have the characteristic pineocytomatous/neurocytic rosettes, which is an irregular circular/flower-like arrangement of cells with a large meshwork of fibers (neuropil) at the centre.[1] Pineocytomatous/neurocytic rosettes are superficially similar to Homer Wright rosettes; however, they differ from Homer Wright rosettes as they have (1) more neuropil at centre of the rosette and, (2) the edge of neuropil meshwork irregular/undulating ...
Vertical pedigree: Remington RosetteVertical pedigree: Remington Rosette
Remington Rosette. A vertical pedigree lists the siblings of each dog in the pedigree. Siblings are found by searching for dogs in the database with the same parents. They may be from the same litter or from another breeding of the same parents. In most cases, this pedigree will be incomplete, as not all dogs have all their siblings entered in the database.. Vertical pedigree: ...
Lauren Oberlin - H&M Black Cropped Sweater, Pacsun Tribal Skirt, H&M Velvet Boots, Forever 21 Rosette Ring - THOSE SLEEPLESS...Lauren Oberlin - H&M Black Cropped Sweater, Pacsun Tribal Skirt, H&M Velvet Boots, Forever 21 Rosette Ring - THOSE SLEEPLESS...
H&M Black Cropped Sweater, Pacsun Tribal Skirt, H&M Velvet Boots, Forever 21 Rosette Ring styled by Lauren Oberlin in THOSE SLEEPLESS NIGHTS-see looks like this and more on LOOKBOOK.
Deadly Rose Rosette Disease Moves Across the Country | Pennsylvania Gardener Hot PlantsDeadly Rose Rosette Disease Moves Across the Country | Pennsylvania Gardener Hot Plants
Rose gardeners throughout the country need to be vigilant in watching for the symptoms of an increasingly common problem known as rose rosette disease.
Jepson Herbarium: Jepson Flora Project: Jepson eFlora: Streptanthus glandulosusJepson Herbarium: Jepson Flora Project: Jepson eFlora: Streptanthus glandulosus
Habit: Annual, stiff-hairy basally (glabrous throughout). Stem: (0.8)1.5--9(12) dm, simple to branched throughout. Leaf: basal not rosetted, petioled, early-deciduous, coarsely dentate to +- lobed; mid-cauline sessile, 1--12 cm, lance-linear to oblanceolate, entire to coarsely dentate, leaf base lobed to clasping; distal similar, reduced, generally entire. Inflorescence: open, 1-sided or not; terminal sterile flower cluster 0. Flower: calyx bilateral, sepals (3)5--10(13) mm, lanceolate to broadly ovate, white to yellow, rose, purple, or purple-black, glabrous or bristles sparse; petals 7--17 mm, 1--3 mm wide, +- equal or adaxial pair longer, crinkled; filaments in 3 pairs of unequal length; longest pair fused, 5--13 mm; fertile anthers 1--2.5 mm. Fruit: ascending to spreading or reflexed, 3--11 cm, 1.5--2.5 mm wide, straight or curved, not constricted between seeds; valve midveins distinct, glabrous or sparsely to moderately hairy; stigma +- entire; pedicels ascending to spreading, 0.2--3.2 cm. ...
rosette - Wiktionaryrosette - Wiktionary
Part or all of this entry has been imported from the 1913 edition of Websters Dictionary, which is now free of copyright and hence in the public domain. The imported definitions may be significantly out of date, and any more recent senses may be completely missing ...
Happy Home Baking: A Box of RosesHappy Home Baking: A Box of Roses
I worked on the piped cookies first as I was feeling excited at the thought of piping cookies...this is something I have not done before. The recipe is straight forward and down right simple...requires minimum ingredients and the dough was done in no time. The only difficult part was piping them! I thought I could use my Wilton 2D decorating tip as it gives very impressive rosettes just like this one I did. To my dismay, the tip is not suitable for piping the cookies, the dough which pass through the gaps on the tip was just too thin. Fortunately I have another huge star tip, a Wilton 1C, this one worked quite well. Although I was able to pipe decent looking rosettes they are nothing close to what I had in mind. I can only blame my lack of skill. I am quite hopeless at piping...I do not know the right technique to position the tip and I am totally clueless how to create a nice swirl?! I though it would be easier to pipe pretty swirls with a cookie dough since it is firm, but I was wrong ...
Traumatic rosette cataract | BMJ Case ReportsTraumatic rosette cataract | BMJ Case Reports
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Rose diseaseRose disease
many of the roses in my garden are suffering with something unusual. I hope it isnt rose rosette disease. The nearest thing I can find to it is damage by weed killer. I dont use any. I have also seen it in another garden down the road about a mile and a half. I live rurally ...
A Thorny Infection Attacks North Texas Rosebushes | KERA NewsA Thorny Infection Attacks North Texas Rosebushes | KERA News
Prized rosebushes in North Texas are at risk from an infection called Rose Rosette. The disease is incurable and has already cost Southlake about a half
Myths about stearate risksMyths about stearate "risks"
A common reference is to a 1990 study in the journal Immunology, but the reference is hardly satisfactory as a demonstration of the alleged harm of stearic acid. This was a test tube study that has not been replicated in living beings, with an artificial situation providing high concentrations of stearic acid exposed to isolated immune cells for hours at a time. It was actually done as a way to investigate whether prolonged high dose stearic acid administration could possibly be used to suppress the immune system for an autoimmune disease treatment. (5) It was definitely NOT a demonstration that this would work the same way with dietary supplements or with foods containing stearic acid. The effect was dose- and time- dependent; with a sustained, prolonged exposure over an 8-hour period that is impossible to replicate in the living human body. For a test tube study, it would first have to be shown that the mechanism was valid in vivo before it could be considered reasonable to extrapolate it to ...
Elephant trunk (astronomy)Elephant trunk (astronomy)
Germ-band extensionGerm-band extension
Mollugo verticillataMollugo verticillata
Histidine-rich glycoproteinHistidine-rich glycoprotein
Climate of Mount KenyaClimate of Mount Kenya
Mount KenyaMount Kenya
Organ Pipes National ParkOrgan Pipes National Park
Crystal CavernCrystal Cavern
PiperiaPiperia
NeosauropodaNeosauropoda
RicciaRiccia
EctomesenchymomaEctomesenchymoma
Celery mosaic virusCelery mosaic virus
Endocrinology of reproductionEndocrinology of reproduction
Cowtail stingrayCowtail stingray
HemipenisHemipenis
Rhopalosiphum rufiabdominaleRhopalosiphum rufiabdominale
GroESGroES
AstroblastomaAstroblastoma
Withaferin AWithaferin A
Desert roseDesert rose
H. Hugh FudenbergH. Hugh Fudenberg
FlexnerFlexner
NeuroblastomaNeuroblastoma
SU6656SU6656
Rosette NebulaRosette Nebula
Rosette (zoology)Rosette (zoology)
Rosette (schizont appearance)Rosette (schizont appearance)
Flexner-Wintersteiner rosetteFlexner-Wintersteiner rosette
NebulaNebula
LeafLeaf
BrassicaceaeBrassicaceae
PhyllotaxisPhyllotaxis
HemipenisHemipenis
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SnowSnow
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Mycobacterium fortuitumMycobacterium fortuitum
GrotesqueGrotesque
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Mlima Kenya, kamusi elezo huruMlima Kenya, kamusi elezo huru
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MonocotyledonMonocotyledon
Snow leopardSnow leopard
Actinic keratosisActinic keratosis
CerebellumCerebellum
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BleachBleach
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Cell wallCell wall
Venus flytrapVenus flytrap
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Rosette FormationImmune Adherence ReactionErythrocytesReceptors, FcReceptors, ComplementImmunoglobulin Fc FragmentsLymphocytesReceptors, Antigen, B-CellLeukemia, LymphoidT-LymphocytesComplement C3Immunologic TechniquesReceptors, Complement 3bBinding Sites, AntibodyAntilymphocyte SerumSheepB-LymphocytesImmunoglobulin GComplement System ProteinsDinitrochlorobenzeneCytochalasin BImmunoglobulin MBlood Group AntigensComplement C3bLeukocyte CountPlasmodium falciparumAntigen-Antibody ComplexAntibodies, MonoclonalMonocytesAntigen-Antibody ReactionsImmune SeraPhagocytosisMalaria, FalciparumCell AdhesionSpleenTrypsinLectinsAntigens, SurfaceGuinea PigsCell SeparationLymphocyte ActivationEpitopesFluorescent Antibody TechniqueThymus GlandReceptors, IgGCytotoxicity Tests, ImmunologicReceptors, ImmunologicLymphomaMicroscopy, ElectronBinding, CompetitiveMacrophagesCells, CulturedCell MembraneCell LineNeutrophilsRabbits
Alveolar macrophage-lymphocyte rosette formation: failure of l...Alveolar macrophage-lymphocyte rosette formation: failure of l...
Rosette formation by mouse lymphocytes. II. T-cell specificities in by villena A. Arnaiz, M I. Gyongyossy et al."Rosette formation by mouse lymphocytes. II. T-cell specificities in " by villena A. Arnaiz, M I. Gyongyossy et al.
Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58 - Research...Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58 - Research...
Chapter 2.2Chapter 2.2
A marker for activated macrophages based on resistance of fc rosette f by R S. Kerbel"A marker for activated macrophages based on resistance of fc rosette f" by R S. Kerbel
Rosette Formation by Plasmodium Coatneyi-Infected Red Blood Cells | The American Journal of Tropical Medicine and HygieneRosette Formation by Plasmodium Coatneyi-Infected Red Blood Cells | The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene | The time course of cytoadhesion, immunoglobulin binding, rosette...The American Journal of Tropical Medicine and Hygiene | The time course of cytoadhesion, immunoglobulin binding, rosette...
Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line | Journal of Cell...Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line | Journal of Cell...
The roles and regulation of multicellular rosette structures during morphogenesis | DevelopmentThe roles and regulation of multicellular rosette structures during morphogenesis | Development
Calcium signaling mediates five types of cell morphological changes to form neural rosettes | Journal of Cell ScienceCalcium signaling mediates five types of cell morphological changes to form neural rosettes | Journal of Cell Science
Lymphocytes bearing Fcγ receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and...Lymphocytes bearing Fcγ receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and...
IMSEAR at SEARO: Rosette formation in osteosarcoma.IMSEAR at SEARO: Rosette formation in osteosarcoma.
Plasmodium falciparum Rosette Formation Assay -BIO-PROTOCOLPlasmodium falciparum Rosette Formation Assay -BIO-PROTOCOL
Rosette formation - janoschka Packaging, Decor, Security, Solutions, PrepressRosette formation - janoschka Packaging, Decor, Security, Solutions, Prepress
Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes. - Nuffield...Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes. - Nuffield...
Plus itPlus it
Superstructural Variety from an Alkylated Triazine: Formation of One-Dimensional Hydrogen-Bonded Arrays or Cyclic RosettesSuperstructural Variety from an Alkylated Triazine: Formation of One-Dimensional Hydrogen-Bonded Arrays or Cyclic Rosettes
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. - Nuffield Department of MedicineRheopathologic Consequence of Plasmodium vivax Rosette Formation. - Nuffield Department of Medicine
Rosette formation by Plasmodium vivax - Centre for Tropical Medicine and Global HealthRosette formation by Plasmodium vivax - Centre for Tropical Medicine and Global Health
Rosette Nebula - WikipediaRosette Nebula - Wikipedia
Chandra :: Photo Album :: Rosette Nebula :: Rosette Nebula AnimationsChandra :: Photo Album :: Rosette Nebula :: Rosette Nebula Animations
Derivation of Dopaminergic Neurons (from Human Embryonic Stem Cells) | Thermo Fisher Scientific - CNDerivation of Dopaminergic Neurons (from Human Embryonic Stem Cells) | Thermo Fisher Scientific - CN
Elephant trunk (astronomy) - WikipediaElephant trunk (astronomy) - Wikipedia
Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or...Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or...
Plus itPlus it
Importance of factors H and I for the adherence of C3b-coated erythrocytes to cellsImportance of factors H and I for the adherence of C3b-coated erythrocytes to cells
Stimulation of the immunological reactivity of cancer patients by Eleutherococcus extract]Stimulation of the immunological reactivity of cancer patients by Eleutherococcus extract]
ARA: accurate, reliable and active histopathological image classification framework with Bayesian deep learning | Scientific...ARA: accurate, reliable and active histopathological image classification framework with Bayesian deep learning | Scientific...
Neuroblastoma - WikipediaNeuroblastoma - Wikipedia
Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and...Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and...
Detecting fetomaternal hemorrhage: a comparison of five methods.Detecting fetomaternal hemorrhage: a comparison of five methods.
UTHSC | Pathology and Laboratory Medicine - Interesting Cases - Case 008 - 61 Year Old Male with a Lung Mass and...UTHSC | Pathology and Laboratory Medicine - Interesting Cases - Case 008 - 61 Year Old Male with a Lung Mass and...
Estimation of the number of T lymphocytes and other rosette-forming cells in human blood in health and disease | SpringerLinkEstimation of the number of T lymphocytes and other rosette-forming cells in human blood in health and disease | SpringerLink
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Rosette FormationImmune Adherence ReactionErythrocytesReceptors, FcReceptors, ComplementImmunoglobulin Fc FragmentsLymphocytesReceptors, Antigen, B-CellLeukemia, LymphoidT-LymphocytesComplement C3Immunologic TechniquesReceptors, Complement 3bBinding Sites, AntibodyAntilymphocyte SerumSheepB-LymphocytesImmunoglobulin GComplement System ProteinsDinitrochlorobenzeneCytochalasin BImmunoglobulin MBlood Group AntigensComplement C3bLeukocyte CountPlasmodium falciparumAntigen-Antibody ComplexAntibodies, MonoclonalMonocytesAntigen-Antibody ReactionsImmune SeraPhagocytosisMalaria, FalciparumCell AdhesionSpleenTrypsinLectinsAntigens, SurfaceGuinea PigsCell SeparationLymphocyte ActivationEpitopesFluorescent Antibody TechniqueThymus GlandReceptors, IgGCytotoxicity Tests, ImmunologicReceptors, ImmunologicLymphomaMicroscopy, ElectronBinding, CompetitiveMacrophagesCells, CulturedCell MembraneCell LineNeutrophilsRabbits
LymphocytesMacrophagesCellsPlasmodiumSpontaneousNebulaInhibitionNeuralErythrocytesInduceVitroDifferentiation of hESCIsolatesTumorsEpendymalFalciparumEpithelialMalariaStructuresMorphogenesisCESAApical constrictionColoniesMolecularFormMechanismsCellularHeparinClonesSuppressesElongationInfiltrationCytoskeletalLigandTightlyFunctional significanceAdultAstronomersDiagnosticMembranePromotesProcessesTissuesPersistenceCelluloseDescribeStar-formation
Lymphocytes3
Macrophages1
  • A marker for activated macrophages based on resistance of fc rosette formation to the inhibiting effects of anti-h2 serum. (jax.org)
Cells2
  • We established a novel rosetting model by co-culturing HLA-II matched PBMCs with HL cell lines and show IS formation with activation of rosetting T cells. (rug.nl)
  • In conclusion, T cell rosetting in HL is established by formation of the IS and activation of rosetting T cells critically depends on both TCR-HLA-II and CD2-CD58 interaction. (rug.nl)
Plasmodium10
Spontaneous3
Nebula6
Inhibition1
Neural14
Erythrocytes2
  • In particular, we have studied when the adhesive and antigenic modifications appear on the infected erythrocyte surface that mediate binding to C32 melanoma cells (cytoadherence) or to erythrocytes (rosette formation) during a complete 48-hr life cycle of the parasite. (ajtmh.org)
  • This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. (ox.ac.uk)
Induce3
Vitro3
  • RBCs from P. coatneyi -infected rhesus monkeys ( Macaca-mulatta ) were collected, allowed to mature overnight in vitro and found to form rosettes as hypothesized. (ajtmh.org)
  • This protocol describes an in vitro assay to monitor rosette formation by P. falciparum -infected red blood cells, including procedures for rosette enrichment, maintenance of rosetting phenotype and assays for rosetting with RBC labeled using lipophilic fluorescent probes. (bio-protocol.org)
  • By using this in vitro model of early human embryogenesis, we found that hCG/LH signal via LHCGR to promote hESC proliferation and steroidogenesis (P 4 synthesis), and that P 4 signaling is obligatory for both EB and neuroectodermal rosette differentiation. (biomedcentral.com)
Differentiation of hESC1
Isolates4
Tumors2
Ependymal6
Falciparum3
Epithelial3
  • These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. (biologists.org)
  • Recently, it has become apparent that polarized epithelial rosettes are common intermediates that are observed during the organogenesis of multiple organs in diverse species. (biologists.org)
  • The spindle cell subtype may be confused with the spindle cell variant of carcinoid, and epithelial thymomas may exhibit fairly pronounced rosette formation. (cap.org)
Malaria1
  • Sera of children with cerebral disease generally lacked anti-rosette activity, while many sera from children with uncomplicated malaria showed strong anti-rosette activity when tested against the patients' ow parasites. (ox.ac.uk)
Structures1
Morphogenesis2
  • Our findings suggest that apical constriction of cell membranes spatially confines regions of strong cell-cell adhesion and restricts the number of tightly interconnected cells into cellular rosettes, which ensures the correct deposition of neuromasts during morphogenesis of the posterior lateral line organ. (biologists.org)
  • Despite these differences, the many contexts in which rosettes are formed suggest that they constitute a broadly utilized mechanism during morphogenesis. (biologists.org)
CESA1
  • A 36- CESA rosette was compatible with most descriptions of the microfibrils in primary cell walls up to the time of the Delmer (1999) review. (plantphysiol.org)
Apical constriction1
  • By contrast, rosettes that are formed through apical constriction can persist for extended periods of time, may or may not resolve, and often remodel to form a functional structure or organ. (biologists.org)
Colonies3
Molecular7
Form3
  • Priming with granulocyte-macrophage CSF, IL-4, or IL-5 is required for eosinophils to form rosettes with IgA-beads. (jimmunol.org)
  • In Nicole King's lab at Berkeley, however, by treating them with antibiotics-a ruthless measure to stop the choanoflagellates being overrun by bacteria-researchers found the rosettes would no longer form. (the-scientist.com)
  • Synthesis of 18-chain microfibrils is consistent with a model for cellulose-synthesizing complexes in which three cellulose synthase polypeptides form a particle and six particles form a rosette. (plantphysiol.org)
Mechanisms2
  • Whereas the intracellular mechanisms that participate in rosette formation are relatively well conserved between species and organ systems, the extracellular cues that regulate rosette formation are diverse. (biologists.org)
  • Finally, we compare and contrast the mechanisms driving rosette formation to highlight similarities and differences across organ systems. (biologists.org)
Cellular8
Heparin1
Clones3
Suppresses1
Elongation2
  • Generally, rosettes that are formed through the planar polarized mechanism resolve relatively quickly and typically contribute to processes involving tissue elongation. (biologists.org)
  • For example, the resolution of rosettes that are formed during convergent extension (see Glossary, Box 1 ) drives tissue elongation. (biologists.org)
Infiltration1
  • Conclusion: DIAIH is different from AIH in liver function tests, levels of immunoglobulin and pathological characteristic such as interface hepatitis, plasma cell infiltration, portal fibrosis and Rosette formation. (alliedacademies.org)
Cytoskeletal1
  • These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. (biologists.org)
Ligand1
  • ICAM-1 and CD36 are the main host cell receptors, while PfEMP1-DBLα is a major parasite ligand, which can contribute to rosette formation. (biomedcentral.com)
Tightly1
Functional significance1
Adult1
  • Insects that naturally attach thistle include the adult thistle-head weevil, thistle rosette weevil, thistle-stem gall fly, flower weevil, stem-mining weevil, yellow starthistle bud weevil, and yellow starthistle hairy weevil. (wikihow.com)
Astronomers2
  • The combination of the X-ray and optical data lead astronomers to believe that stars are still forming in the central cluster of the Rosette, known as NGC 2237. (harvard.edu)
  • Astronomers study elephant trunks because of their unique formation process and use 2-D and 3-D simulations to try to understand how this phenomenon occurs. (wikipedia.org)
Diagnostic1
  • In our opinion rosettes in an osteosarcoma should be documented both from a differential diagnostic point of view and also to elucidate definitive prognostic implications. (who.int)
Membrane1
  • In land plants (embryophytes) and charophycean green algae, each microfibril emerges from a rosette of six particles on the plasma membrane, so it is reasonable to assume that a microfibril contains a multiple of six (1→4)-β-glucan chains, but the value of that multiple remains uncertain. (plantphysiol.org)
Promotes2
Processes1
Tissues1
  • The 3′UTR of At UBP1b is sufficient to repress reporter protein expression in tissues expressing miR854 or miR855 (rosette leaves and flowers, respectively) but not where both miRNAs are absent (cauline leaves). (plantcell.org)
Persistence1
Cellulose2
  • A cellulose synthesis complex with a "rosette" shape is responsible for synthesis of cellulose chains and their assembly into microfibrils within the cell walls of land plants and their charophyte algal progenitors. (plantphysiol.org)
  • This study strongly supports the "hexamer of trimers" model for the rosette cellulose synthesis complex that synthesizes an 18-chain cellulose microfibril as its fundamental product. (plantphysiol.org)
Describe1
Star-formation5
Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58 - Research...
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Chapter 2.2
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The roles and regulation of multicellular rosette structures during morphogenesis | Development
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Chandra :: Photo Album :: Rosette Nebula :: Rosette Nebula Animations
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Lymphocytes bearing Fcγ receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and...
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Evidence for the Role of Immobilization of Ligand-Occupied Membrane Receptors in Signal Transduction | SpringerLink
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Frontiers | Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice | Frontiers in Aging...
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Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during...
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Herschel space observatory peers into stellar nursery - Scientific American
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Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex |...
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