The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.
A method for the detection of very small quantities of antibody in which the antigen-antibody-complement complex adheres to indicator cells, usually primate erythrocytes or nonprimate blood platelets. The reaction is dependent on the number of bound C3 molecules on the C3b receptor sites of the indicator cell.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.
Molecules on the surface of some B-lymphocytes and macrophages, that recognize and combine with the C3b, C3d, C1q, and C4b components of complement.
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.
Molecular sites on or in some B-lymphocytes and macrophages that recognize and combine with COMPLEMENT C3B. The primary structure of these receptors reveal that they contain transmembrane and cytoplasmic domains, with their extracellular portion composed entirely of thirty short consensus repeats each having 60 to 70 amino acids.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
A cytotoxic member of the CYTOCHALASINS.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Antibodies produced by a single clone of cells.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Adherence of cells to surfaces or to other cells.
An encapsulated lymphatic organ through which venous blood filters.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Sites on an antigen that interact with specific antibodies.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.
Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.
A general term for various neoplastic diseases of the lymphoid tissue.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Established cell cultures that have the potential to propagate indefinitely.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Establishment of an activated macrophage cell line, A-THP-1, and its properties. (1/1162)

A new macrophage cell line with activated character and unique morphology was isolated by selecting adherent cells from the human monocytic cell line THP-1. The original THP-1 cells had been cultured for more than 9 years using 25 cm2 flasks, when cells with a different morphology appeared, adhering to the bottoms of the culture flasks. These were selected by discarding floating nonadherent cells at every subculture. Enrichment of adherent THP-1 cells with long processes proceeded during the cultivation. These adherent THP-1 showed remarkable phenotypic changes, not only morphologically, but also functionally. Namely, increased phagocytic activity, HLA-DR expression and MLR stimulator activity were remarkable. This adherent cell line was designated as activated-THP-1 (A-THP-1), since it demonstrated characteristics of activated macrophages continuously without exogenous stimulation. A cloned A-THP-1 cell line (A-THP-1 C1) also showed the same features and contained about 10% multinucleated giant cells probably caused by cell fusion. This A-THP-1 cell line, the first activated macrophage cell line to be established, provides a good model for understanding of activation mechanisms of macrophages and multinucleation. In this paper, morphological, immunological, and biological characters of this cell line are described.  (+info)

Protein kinase C and a calcium-independent phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells. (2/1162)

Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythrocytes (EIgG) in a calcium-independent manner. Incubation of MM6 with bromoenol lactone, an inhibitor of the phagocytic phospholipase (pPL), coordinately decreased phagocytosis and pPL activity. This inhibition was overcome by exogenous arachidonic acid, suggesting that phagocytosis requires pPL activation and arachidonic acid release. MM6 phagocytosis was inhibited with staurosporine and activated with diacylglycerol, supporting a role for protein kinase C (PKC) in this process. The pPL activators mastoparan and melittin restored phagocytosis to PKC-inhibited cells, suggesting that pPL lies downstream from PKC. These results suggest that the MM6 signal transduction pathway for IgG-mediated phagocytosis is similar to that of monocytes (PKC-->pPL-->arachidonic acid-->phagocytosis). The results are discussed in the context of the finding that MM6 exhibit low phagocytosis relative to monocytes and thus may represent an attractive cell line for molecular manipulation in "recovery of function" studies.  (+info)

Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89. (3/1162)

Cellular receptors for IgA (FcalphaR) mediate important protective functions. An extensive panel of site-directed mutant IgAs was used to identify IgA residues critical for FcalphaR (CD89) binding and triggering. Although a tailpiece-deleted IgA1 was able to bind and trigger CD89, antibodies featuring CH3 domain exchanges between human IgA1 and IgG1 could not, indicating that both domains but not the tailpiece are required for FcalphaR recognition. To further investigate the role of the interdomain region, numerous IgA1s, each with a point substitution in either of two interdomain loops (Leu-257-Gly-259 in Calpha2; Pro-440-Phe-443 in Calpha3), were generated. With only one exception (G259R), substitutions produced either ablation (L257R, P440A, A442R, F443R) or marked reduction (P440R) in CD89 binding and triggering. Further support for involvement of these interdomain loops was provided by interspecies comparisons of IgA. Thus a human IgA1 mutant, LA441-442MN, which mimicked the mouse IgA loop sequence through substitution of two adjacent residues in the Calpha3 loop, was found, like mouse IgA, not to bind CD89. In contrast, bovine IgA1, identical to human IgA1 within these interdomain loops despite numerous differences elsewhere in the Fc region, did bind CD89. We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction.  (+info)

Plasmodium falciparum malaria: rosettes are disrupted by quinine, artemisinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. (4/1162)

An assay was developed measuring the disruption of rosettes between Plasmodium falciparuminfected (trophozoites) and uninfected erythrocytes by the antimalarial drugs quinine, artemisinin mefloquine, primaquine, pyrimethamine, chloroquine and proguanil. At 4 hr incubation rosettes were disrupted by all the drugs in a dose dependent manner. Artemisinin and quinine were the most effective anti-malarials at disrupting rosettes at their therapeutic concentrations with South African RSA 14, 15, 17 and The Gambian FCR-3 P. falciparum strains. The least effective drugs were proguanil and chloroquine. A combination of artemisinin and mefloquine was more effective than each drug alone. The combinations of pyrimethamine or primaquine, with quinine disrupted more rosettes than quinine alone. Quinine may be an effective drug in the treatment of severe malaria because the drug efficiently reduces the number of rosettes.  (+info)

Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. (5/1162)

Cytoadherence of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium is believed to be a key factor in the development of cerebral malaria. Erythrocyte rosette formation has been correlated with malaria severity in studies from east and west Africa. We cultured fresh isolates from Malawian children with severe (n = 76) or uncomplicated (n = 79) malaria to pigmented trophozoite stage and examined rosette formation and adherence to CD36, intercellular adhesion molecule-1 (ICAM-1), chondroitin sulfate A (CSA), and thrombomodulin (TM). Most (126 of 148) isolates bound to CD36, and 76 of 136 bound to ICAM-1. Fewer bound to CSA (40 of 148) or TM (23 of 148). After controlling for parasitemia, there was an inverse association between binding to CD36 (P = 0.004) or ICAM-1 (P = 0.001) and disease severity. Parasites from children with severe malaria anemia bound least to CD36, whereas ICAM-1 binding was lowest in children with cerebral malaria. There was no difference in rosette formation between any of the groups. In Malawian children, there was no evidence of a positive association between adherence to any of the receptors examined and disease severity. The negative association found raises the possibility that adherence to certain receptors could instead be an indicator of a less pathogenic infection.  (+info)

In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. (6/1162)

Immune evasion is critical for survival of viruses that establish persistent or recurrent infections. However, at the molecular level, little is known about how viruses evade immune attack in vivo. Herpes simplex virus (HSV)-1 glycoprotein gC has two domains that are involved in modulating complement activation; one binds C3, and the other is required for blocking C5 and properdin (P) binding to C3. To evaluate the importance of these regions in vivo, HSV-1 gC mutant viruses were constructed that lacked one or both gC domains and studied in a murine model of infection. Each gC region of complement regulation contributed to virulence; however, the C3 binding domain was far more important, as virus lacking this domain was much less virulent than virus lacking the C5/P inhibitory domain and was as attenuated as virus lacking both domains. Studies in C3 knockout mice and mice reconstituted with C3 confirmed that the gC domains are inhibitors of complement activation, accounting for a 50-fold difference in virulence between mutant and wild-type viruses. We conclude that the C3 binding domain on gC is a major contributor to immune evasion and that this site explains at a molecular level why wild-type virus resists complement attack.  (+info)

Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women. (7/1162)

We examined the formation of Plasmodium falciparum erythrocyte rosettes using parasite isolates from placental or peripheral blood of pregnant Malawian women and from peripheral blood of children. Five of 23 placental isolates, 23 of 38 maternal peripheral isolates, and 136 of 139 child peripheral isolates formed rosettes. Placental isolates formed fewer rosettes than maternal isolates (range, 0 to 7. 5% versus 0 to 33.5%; P = 0.002), and both formed fewer rosettes than isolates cultured from children (range, 0 to 56%; P < 0.0001). Rosette formation is common in infections of children but uncommon in pregnancy and rarely detected in placental isolates.  (+info)

Autologous T cells control B-chronic lymphocytic leukemia tumor progression in human-->mouse radiation chimera. (8/1162)

B-chronic lymphocytic leukemia (B-CLL) is characterized by the clonal accumulation of CD5+ B cells. It has been suggested that CLL cells may be regulated by inhibitory and growth-promoting signals exerted by autologous T cells. We have recently described a model for human B-CLL in which peripheral blood mononuclear cells (PBMCs) are transplanted into the peritoneal cavity of lethally irradiated mice radioprotected with bone marrow from mice with severe combined immunodeficiency. In this model, adoptive transfer of low-stage PBMCs leads to marked engraftment of T cells or combined T and CLL cell engraftment, whereas infusion of high-stage PBMCs leads to dominance of CLL cells with a miniscule level of T-cell engraftment. This mutual exclusive pattern of engraftment indicated that T cells might control the expansion of tumor cells in the peritoneum of recipient BALB/c mice. In the present study, we further investigated this question and we demonstrate that in vivo T-cell depletion, using OKT3 antibody, markedly enhances the engraftment of B-CLL cells from patients with early-stage disease. In mice receiving PBMCs from 11 donors with advanced-stage disease, the results were more heterogeneous. In five patients the results were similar to those observed in early stage, whereas in two cases no CLL cell engraftment was found in the absence of T cells. The addition of purified T cells to PBMCs led to a substantial decrease of CLL engraftment in three advanced-stage cases. These results strengthen the working hypothesis that autologous T cells can actively suppress the expansion of the pathological cells in human-->mouse radiation chimera. This effect is prominent in early-stage disease, whereas in advanced stage suppressive and/or stimulatory effects may occur in different patients. The interaction of T cells with tumor cells and the potential of autologous T cell/immune-therapy in CLL can be further explored in this model.  (+info)

The two main types of lymphoid leukemia are:

1. Acute Lymphoblastic Leukemia (ALL): This type of leukemia is most commonly seen in children, but it can also occur in adults. It is characterized by a rapid increase in the number of immature white blood cells in the blood and bone marrow.
2. Chronic Lymphocytic Leukemia (CLL): This type of leukemia usually affects older adults and is characterized by the gradual buildup of abnormal white blood cells in the blood, bone marrow, and lymph nodes.

Symptoms of lymphoid leukemia include fatigue, fever, night sweats, weight loss, and swollen lymph nodes. Treatment options for lymphoid leukemia can vary depending on the type of cancer and the severity of symptoms, but may include chemotherapy, radiation therapy, or bone marrow transplantation.

Falciparum malaria can cause a range of symptoms, including fever, chills, headache, muscle and joint pain, fatigue, nausea, and vomiting. In severe cases, the disease can lead to anemia, organ failure, and death.

Diagnosis of falciparum malaria typically involves a physical examination, medical history, and laboratory tests to detect the presence of parasites in the blood or other bodily fluids. Treatment usually involves the use of antimalarial drugs, such as artemisinin-based combination therapies (ACTs) or quinine, which can effectively cure the disease if administered promptly.

Prevention of falciparum malaria is critical to reducing the risk of infection, and this includes the use of insecticide-treated bed nets, indoor residual spraying (IRS), and preventive medications for travelers to high-risk areas. Eliminating standing water around homes and communities can also help reduce the number of mosquitoes and the spread of the disease.

In summary, falciparum malaria is a severe and life-threatening form of malaria caused by the Plasmodium falciparum parasite, which is responsible for the majority of malaria-related deaths worldwide. Prompt diagnosis and treatment are essential to prevent complications and death from this disease. Prevention measures include the use of bed nets, indoor spraying, and preventive medications, as well as reducing standing water around homes and communities.

There are several types of lymphoma, including:

1. Hodgkin lymphoma: This is a type of lymphoma that originates in the white blood cells called Reed-Sternberg cells. It is characterized by the presence of giant cells with multiple nucleoli.
2. Non-Hodgkin lymphoma (NHL): This is a type of lymphoma that does not meet the criteria for Hodgkin lymphoma. There are many subtypes of NHL, each with its own unique characteristics and behaviors.
3. Cutaneous lymphoma: This type of lymphoma affects the skin and can take several forms, including cutaneous B-cell lymphoma and cutaneous T-cell lymphoma.
4. Primary central nervous system (CNS) lymphoma: This is a rare type of lymphoma that develops in the brain or spinal cord.
5. Post-transplantation lymphoproliferative disorder (PTLD): This is a type of lymphoma that develops in people who have undergone an organ transplant, often as a result of immunosuppressive therapy.

The symptoms of lymphoma can vary depending on the type and location of the cancer. Some common symptoms include:

* Swollen lymph nodes
* Fever
* Fatigue
* Weight loss
* Night sweats
* Itching

Lymphoma is diagnosed through a combination of physical examination, imaging tests (such as CT scans or PET scans), and biopsies. Treatment options for lymphoma depend on the type and stage of the cancer, and may include chemotherapy, radiation therapy, immunotherapy, or stem cell transplantation.

Overall, lymphoma is a complex and diverse group of cancers that can affect people of all ages and backgrounds. While it can be challenging to diagnose and treat, advances in medical technology and research have improved the outlook for many patients with lymphoma.

A rosette is a rose-like marking or formation found on the fur and skin of some animals, particularly cats. Rosettes are used ... However, some mature lions may keep traces of their rosette patterns throughout life. For the lion cub, the rosette marking act ... These big cats have rosettes on their bodies in random combination and pattern. Young lion (Panthera leo) cubs have rosette ... Cheetah - the king cheetah variety has rosettes Jaguar Leopard - smaller, denser rosettes than the jaguar, lacking central ...
Yadon's piperia exhibits a basal rosette leaf formation. The subsurface architecture of this terrestrial wild orchid consists ... A basal rosette of leaves develops from the tuber at the surface of the soil, each of the two or three leaves being lanceolate ...
Carlqvist, P.; Gahm, G. F.; Kristen, H. (2002). "Formation of Twisted Elephant Trunks in the Rosette Nebula". Astrophysics and ... The Rosette Nebula is an example of an unusual shape that an elephant trunk can assume. It has a double helix structure instead ... The EGGs and the column of gas "downwind" from them are the basic formations of an elephant trunk. Elephant trunks form on the ... "Dynamical models for the formation of elephant trunks in H ii regions". Whitlock, Laura. "What is a light year and how is it ...
The rosette is a formation characteristic of schizonts in infection by the reptile parasites Plasmodium tropiduri and P. ...
... higher-ordered rosette formations have been observed in which five or more cells meet at a vertex. Multicellular rosettes form ... Blankenship, J. T., Backovic, S. T., Sanny, J. S., Weitz, O. and Zallen, J. A. (2006). Multicellular rosette formation links ... Neighbor exchange and multicellular rosette formation involve oriented junctional remodeling, which indicates that the ...
At maturity the plant may lose its characteristic basal rosette formation. Leaves are approximately 1-3 cm in length and ...
It can inhibit rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the ... Shatsky M, Saigo K, Burdach S, Leung LL, Levitt LJ (May 1989). "Histidine-rich glycoprotein blocks T cell rosette formation and ... Leung LL, Nachman RL, Harpel PC (January 1984). "Complex formation of platelet thrombospondin with histidine-rich glycoprotein ... Silverstein RL, Leung LL, Harpel PC, Nachman RL (November 1984). "Complex formation of platelet thrombospondin with plasminogen ...
"Equilibrium freezing of leaf water and extracellular ice formation in Afroalpine 'giant rosette' plants". Planta. Springer- ...
"Equilibrium freezing of leaf water and extracellular ice formation in Afroalpine 'giant rosette' plants". Planta. 162 (3): 276- ... Giant rosette senecios form single-aged stands that drive community structure over decades. Many plant species in the Afro- ... One adaptation is known as the giant rosette, which is exhibited by giant senecio, giant lobelia and giant thistle (Carduus), ... ISBN 978-0-7146-1812-8. Speck, Heinrich (1982). "Soils of the Mount Kenya Area: Their formation, ecology, and agricultural ...
Rosette rock is a radial array of basalt columns. Rosette rock formation seen about 500 metres (1,600 ft) upstream of the Organ ... Frequent access to this formation is likely to cause deterioration of this formation. ... Its formation is attributed to the cooling of "a pocket of lava, probably in a spherical cave formed from an earlier lava flow ... The width of each pipe in the formation is about 1 metre (3 ft 3 in); only some of the columns are vertical while most other ...
The rosette formation of germline cyst cells allows cells to be in the closest configuration for communication. Throughout the ... 2004). Formation, architecture and polarity of female germline cyst in Xenopus. Dev Biol 266: 43-61. doi:10.1016/j.ydbio. ... 1997). Germline cyst formation in Drosophila. Annu. Rev. Genet. 31: 405-428. DOI: 10.1146/annurev.genet.31.1.405 Yamashita, Y. ... Asymmetric fusome partitioning and new formation followed by fusion occurs at each mitotic division. In spermatogenesis, the ...
Plant parts may also appear desiccated and distorted or display the formation of rosettes. High pest densities can cause ... followed by severe damage at tiller formation. In the summer of 1990, the aphid appeared as a major pest of a squash crop in ...
Skin associated with the scapular blade is the largest, arranged in rosettes (spiral formations) with a smooth, hexagonal shape ... from the Upper Triassic Ischigualasto Formation of northwestern Argentina". ZooKeys (63): 55-81. Sereno, Paul; Martinez Ricardo ...
... "onyx crusts and rosettes", stalactites and stalagmites, and "a petrified waterfall". Two named formations were the "Capitol ... Stalactites, stalagmites, and onyx crusts and rosettes are present. "Capitol Dome" is a stalagmitic deposit upon one wall which ... is a small cavern containing crystal formations located in Clay, Alabama, USA. The cavern was discovered in 1840 by a Thomas ... "beautiful formations" including what appeared to be "metallic draperies". In 1946, however, biologist Edward McCrady described ...
Asexual reproduction occurs by spores, by fragmentation of the rosettes, and by formation of apical tubers. Spores are large ( ... the thallus may be strap-shaped and about 0.5 to 4 mm wide with dichotomous branches or may form rosettes or hemirosettes up to ...
2013). "THE PROGRESSION OF STAR FORMATION IN THE ROSETTE MOLECULAR CLOUD". Astrophysical Journal. 769 (2): 140. arXiv:1303.1226 ... Wikimedia Commons has media related to Rosette Nebula. Rosette Nebula (SEDS) Chandra Observatory study of the Rosette Nebula ... Rosette Nebula Astronomy Picture of the Day Dust Sculptures in the Rosette Nebula - 2007 June 6 Dust Sculptures in the Rosette ... 2010 February 14 Slooh Videocast on Rosette Nebula Rosette Nebula from the Netherlands Deep image of the Rosette Nebula The ...
... fibrous histiocytoma-like areas can be observed as well as neurofibromatous and neuroblastic components with rosette formation ...
... distorted leaf growth with exaggerated rosette formation. Some strains of celery mosaic virus cause a "crinkled" pattern to ...
A rosette is a cell formation in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. The central hub may ... Homer Wright rosettes are considered "pseudo" in the sense that they are not true rosettes. True rosettes are Flexner- ... A rosette is a structure or formation resembling a rose, such as the clusters of polymorphonuclear leukocytes around a globule ... A Flexner-Wintersteiner rosette is a spoke-and-wheel shaped cell formation seen in retinoblastoma and certain other ophthalmic ...
Progesterone induces formation of tertiary side-branches in the mammary glands during puberty and during the luteal phase of ... The production of progesterone at this time induces embryroid body (akin to blastulation) and rosette (akin to neurulation) ... Estrogens and progesterone promote mammary epithelial cell proliferation resulting in the formation of the primary and ... or rosettes (neurulation). RU-486, a drug commonly used to terminate pregnancy in its early stages, acts not only to abort the ...
Stars form out of the interstellar medium, with this formation mostly occurring in giant molecular clouds such as the Rosette ... An example problem is that of star formation. ...
... exhibits a single veined flower one to two millimeters in width and a basal rosette leaf formation. "Piperia". Tropicos. ... A basal rosette of leaves develops from the tuber at the surface of the soil, each of the two or three leaves being lanceolate ...
The typical size of such groups is three individuals (larger groups, up to nine, are rare), arranged in a "rosette" formation ... The rosette also orients their less critical tails, containing mechanoreceptors that comprise a secondary warning system, ...
... that underwent seasonal arid conditions and playa lake formation as indicated by the presence of fossil gypsum rosettes and ... It overlies the Abrahamskraal Formation (the western correlate of the Middleton Formation). The Teekloof Formation does not ... Geologic formations of South Africa, Permian System of Africa, Permian South Africa, Mudstone formations, Siltstone formations ... The Teekloof Formation is a geological formation that forms part of the Beaufort Group, one of the five geological groups that ...
S. rosetta has been named for the rosette-shaped colonies formed by its cells. Recent studies show a bacterial sulfonolipid, ... called rosette inducing factor (RIF-1) produced by Algoriphagus machipongonensis triggers colony formation in S. rosetta.[ ...
... is characterised by the formation of large, flat rosettes on a thick layer of rhizohyphae, the presence of a ...
Pig semen, like EPF, has been shown to inhibit rosette formation - the rosette inhibition test was positive for one day in sows ... Because the rosette inhibition assay for EPF is indirect, substances that have similar effects may confound the test. ... Smart YC, Roberts TK, Fraser IS, Cripps AW, Clancy RL (Jun 1982). "Validation of the rosette inhibition test for the detection ... Early pregnancy factor is tested for rosette inhibition assay. EPF is present in the maternal serum (blood plasma) shortly ...
... "true rosette" architecture Lacks structural cohesiveness Prominent pseudopapillae formation Localization mostly in cerebral ...
... these molecules inhibit the E rosette and EAC rosette formation by normal B and T lymphocytes. Withaferin A has a specific ... Jilani, K.; Lupescu, A.; Zbidah, M.; Shaik, N.; Lang, F. (2013). "Withaferin A-stimulated Ca2+ entry, ceramide formation and ... To produce Withaferin A from 24-methylene cholesterol, the molecule undergoes several functional changes including formation of ...
... a rosette formation of gypsum and barite with sand inclusions "Desert Rose" (Sting song), a song on Sting's 1999 album Brand ...
Military units and formations established in 1813, French military units and formations of the Napoleonic Wars, Royal guards, ... and was decorated by a surmounted rosette of a ganse cord and of a half-spherical pompom. The cord was tied in front of and ... For its formation the regiment was allocated officers and NCOs from the 20th Dragons of Line, 3rd and 7th Lancers of the Line ... Cavalry regiments of France, 1813 establishments in France, Military units and formations disestablished in 1815). ...
Likewise, the agricultural area in Rashid is very limited, and the spread of sand formations to the west of the city and its ... The latter lent its name to the Rosetta Stone (French: Pierre de Rosette), which was found by French soldiers at the nearby ... Rosetta or Rashid (/roʊˈzɛtə/; Arabic: رشيد Rašīd IPA: [ɾɑˈʃiːd]; French: Rosette [ʁo.zɛt]; Coptic: ϯⲣⲁϣⲓⲧ ti-Rashit, Ancient ... the name Rexi was used by the Crusaders in Middle Ages and Rosetta or Rosette ("little rose" in Italian and French respectively ...
... blue or violet in the interior of the rosette. The different types of ornamental kale are peacock kale, coral prince, kamone ... which contributes to the formation of sulforaphane, a compound under preliminary research for its potential to affect human ...
She received such State Rewards as the Order of the Rising Sun (4th Class, Gold Rays with Rosette) in 2007, The Order of Merit ... In 1978 she defended her doctoral dissertation in philology "Word-formation in Modern Chinese Terminology" in the Institute of ... April 29, 2007 The Order of the Rising Sun (4th Class, Gold Rays with Rosette) for her achievements in the development of ... Actual problems of lexicology, phraseology, terminology and word-formation of the Chinese and Japanese languages Linguistic ...
A leaf rosette at the base may be present or absent. The leaves along the stem are almost always alternately arranged, rarely ... The monoculture formation of an herb layer carpet by this plant has been shown to dramatically alter forests, making them ... The leaves are simple (although are sometimes deeply incised), lack stipules, and appear alternately on stems or in rosettes. ... and few species have flowers that sit individually on flower stems that spring from the axils of rosette leaves. The ...
The agents are then removed concomitant with the formation of fibers. Cellulose is also soluble in many kinds of ionic liquids ... Kimura, S; Laosinchai, W; Itoh, T; Cui, X; Linder, CR; Brown Jr, RM (1999). "Immunogold labeling of rosette terminal cellulose- ... In plants cellulose is synthesized at the plasma membrane by rosette terminal complexes (RTCs). The RTCs are hexameric protein ...
Rosette C, Karin M (March 1995). "Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa ... The sequence and exact composition of molecules during microtubule formation can thus be summarised as follows: A β-tubulin ... Palazzo AF, Cook TA, Alberts AS, Gundersen GG (August 2001). "mDia mediates Rho-regulated formation and orientation of stable ... Khodjakov, A., Cole, R. W., Oakley, B. R. and Rieder, C. L. (2000). "Centrosome-independent mitotic spindle formation in ...
... but as degenerative formations of the erythrocyte. The size (numerical value unknown) of these gametocytes were also described ... central condensation of chromatin possibly reminiscent of a rosette - groupings of cells usually found in tumors. Another ...
The Kayenta Formation is part of the Glen Canyon Group that includes formations in northern Arizona, parts of southeastern Utah ... They pointed out that the ends of the jaws were expanded to the sides, forming a "rosette" of interlocking teeth, similar to ... George dinosaur discovery site in the Moenave Formation of Utah, though the dinosaur itself is not known from the formation, ... based on the position of the specimens within the Kayenta Formation. The Kayenta Formation has yielded a small but growing ...
Located at the end of the Armorican Massif, Cherbourg-en-Cotentin retains traces of the geologic formation, deformed granites ... Bishop of Langres Rosette (b 1959), film actress Olivier Thiébaut [fr] (b 1963), writer and illustrator Wilfried Gohel [fr] (b ...
In 1899 Boland, with his friend and fellow merchant, Callaghan Walsh, began publicly agitating for the formation of a Harbour ... The facade incorporated lineal motifs, large rosettes and starburst medallions, and three glass doors opening onto small ...
The new preparation made clear that a crest was present on the snout and that the rosette was a lot smaller. Many details were ... The holotype of Cearadactylus is MN 7019-V (formerly CB-PV-F-O93), which was discovered in the Romualdo Formation of the ... Steel, L., Martill, D.M., Unwin, D.M. and Winch, J. D. (2005). "A new pterodactyloid pterosaur from the Wessex Formation (Lower ... Cearadactylus is a genus of large anhanguerid pterodactyloid pterosaur from the Romualdo Formation of Brazil, South America. ...
Giant cell formation is likely caused by the detergent properties of bile salts causing a loss of the lateral membrane and ... Cholestatic liver cell rosettes may occur in children with chronic cholestasis. Histologically, this is evident as two or more ... Bile formation begins in bile canaliculi that form between two adjacent surfaces of liver cells (hepatocytes) similar to the ... This can result in the formation of a cholangitic abscess. With treatment, many of the histological features of cholestasis can ...
DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M (1996). "Mapping of the inducible IkappaB ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with ... NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866-9. Bibcode:1997Sci... ...
The decorations feature red ochre paintings of concave hexadecagons and eightfold rosettes on engraved white lime mortar in a ... ISBN 978-90-04-42581-1. Wilbaux, Quentin (2001). La médina de Marrakech: Formation des espaces urbains d'une ancienne capitale ...
The pedunculopontine nucleus is a part of the reticular formation in the brainstem and a main component of the reticular ... This gives in sections characteristic images of "pallissades" or of "rosettes". More than 90% of these synapses are of striatal ... Mesulam, M-M; Geula, C.; Bothwell, M.A.; Hersh, C.B. (1989). "Human reticular formation: cholinergic neurons of the ...
... the formation of isidia (in P. hali, they sometimes grow directly out of the prothallus), and the overall form of the thallus ( ... P. halei has rosette-like thalli). "Phyllopsora amazonica Kistenich & Timdal". Species 2000 & ITIS Catalogue of Life. Species ...
The plants in the lake show rosette growth patterns. In many oligotrophic lakes, nutrients from the atmosphere may effect the ... and red iron formation. Crystal lake is entirely surrounded by outwash plains with two deep wellsadjacent to it. Directly ...
... triggers colony formation in S. rosetta. The effect of RIF-1 on colony formation in S. rosetta has been suggested as an example ... S. rosetta was named for the rosette-shaped colonies formed by its cells. The colonies are held together by adhesion molecules ... Additionally, recent evidence suggests that a bacterial sulfonolipid, called rosette inducing factor (RIF-1) and produced by ...
Highway anti-icing is the snow and ice control practice of preventing the formation or development of bonded snow and ice by ... Many more complex growth patterns also form, which include side-planes, bullet-rosettes, and planar types, depending on the ... CHAPTER 8: Introduction to the Hydrosphere (e). Cloud Formation Processes. Archived December 20, 2008, at the Wayback Machine ... Kenneth G. Libbrecht (January-February 2007). "The Formation of Snow Crystals". American Scientist. 95 (1): 52-59. doi:10.1511/ ...
... as well as archaisms in word formation, like the preservation of the simple superlative suffix in -amo-, as well as phonetic ... as the six-petal rosettes, are popularized, together with new metallurgical techniques and pieces (ear pendants) and some other ... " ("those who work with stones"), in reference to the ancient megaliths and stone formations that are so common in Galicia and ...
The coffers contain highly decorated rosettes, and the ribs in between are also very elaborately decorated. There is a central ... altering the formation of lakes and woodland, as well as moving monuments to new locations. The park and gardens saw 213,721 ...
The Grès supérieurs Formation is the lateral equivalent of the neighbouring Khok Kruat and Phu Phan Formations in Thailand; ... The tips of spinosaurids' upper and lower jaws fanned out into a rosette-like shape that bore long teeth, behind which there ... It is known from fossils collected from the Grès supérieurs Formation of the Savannakhet Basin, the first of which were found ... The first fossils of Ichthyovenator were found in 2010 at Ban Kalum in the Grès supérieurs Formation of the Savannakhet Basin ...
The katun formation by Petar and Vukić Hrabren was part of the Vlach group Donji Vlasi (Lower Vlachs) of nahiye Blagaj - and ... Ornaments include curved lines with trefoil, plastic zigzag, radial circle, rosette, depiction of plastic circles, cluster, rod ...
Following the formation of the Territorial and Army Volunteer Reserve in 1967, the subsidiary title on the bar-brooch was ... In undress uniform or when ribbon bars alone are worn, a recipient of one or more clasps would wear a silver rosette on the ...
... namely the formation of podosome rosettes, otherwise known as invadopodia. SU6656 was initially published as a Src family ...
The Avro 730 supersonic light bomber was also cancelled, as was the Blue Rosette nuclear weapon to arm it. The Royal Auxiliary ... renamed to Yorkshire Brigade upon formation of Fusilier Brigade in 1958 with HQ at Imphal Barracks moving to Strensall Camp in ...
Adel, Rosette. "The art of deception - 31 years of amnesia". Retrieved August 18, 2020. Sumayao, Marco (September 24, 2018). " ... the AFP hyped up its formation,: "43" partly because doing so was good for building up the AFP budget.: "43" As a result, notes ... The Formation of the National Community (1565-1896)" published in 1976. Historiographers agree that the publication of Tadhana ... In some extreme cases where Marcos encouraged the formation of cults so that they could serve as a political weapon, Marcos ...
Rosette Formation E5.478.810 E1.450.495.706. E5.478.594.730. Ryanodine D2.455.849.291.686. Sagittal Sinus Thrombosis C10.228. ...
Lowest inhalation LOEC = 10 mg/m3 (2 ppm); damage to nasal epithelium of rats (mild atrophy, rosette formation in olfactory ... rosette formation, occasional degenerate cells, loss of Bowmans glands and minimal hyperplasia (EURAR 2003). The European ... Adduct formation to proteins:. Positive: CFW and B6C3F1 mouse liver, lung, kidney, brain tissue and blood cells; adduct ... Protein adduct formation. Positive: monkey lung without activation (Lin et al. 2006); mouse liver microsomes (Isbell et al. ...
While segmentation clock and wave front mechanisms have been elucidated to control the size and time of somite formation, ... While segmentation clock and wave front mechanisms have been elucidated to control the size and time of somite formation, ... cell rearrangement patterns during rosette formation and myoblast fusion. J. Embryol. Exp. Morphol. 66, 1-26. ... Kragtorp, K. A., and Miller, J. R. (2007). Integrin alpha5 is required for somite rotation and boundary formation in xenopus. ...
December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ...
2). Moreover, rosette formation is a frequent cytoadhesive phenotype in P. vivax infections and has been associated with an ...
December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ...
Kawata, M., Sekiya, S., Kera, K., Kimura, H. & Takamizawa, H. Neural rosette formation within in vitro spheroids of a clonal ... c, d Patch/FRAP studies on the effect of inhibin A on endoglin-ALK1 (c) and endoglin-ALK4 (d) complex formation. COS7 cells ... 5ai-ii). VEGFA treatment was used as a comparison that also led to similar changes in actin stress fiber formation (Fig. 5a). ... 7a). The subcutaneous model utilized does not induce ascites formation, unlike the intraperitoneal model used previously, where ...
blood parasites, which included a tetrad formation in the shape of a rosette (A), and a hooked, intraerythrocytic form (B).. ...
December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ... December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ...
... which contain mature forms of the parasite in the deep vascular beds of vital organs and rosette formation, thus producing ...
Rosette Formation Entry term(s). Formation, Rosette Formations, Rosette Immunocytoadherence Immunocytoadherences Rosette ... Test des rosettes Entry term(s):. Formation, Rosette. Formations, Rosette. Immunocytoadherence. Immunocytoadherences. Rosette ... Rosette Formation - Preferred Concept UI. M0019274. Scope note. The in vitro formation of clusters consisting of a cell ( ... Rosette formation can be used to identify specific populations of these cells. ...
"Rheopathologic Consequence of Plasmodium vivax Rosette Formation", PLoS Negl Trop Dis, vol. 10, no. 8, p. e0004912, 2016. ... "Subcutaneous abscess formation in septic melioidosis, devoid of associated risk factors", IDCases, vol. 4, pp. 23-23, 2016. ... "Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis", eLife, vol. 9, p ...
... organization of the eukaryote genomes and discusses the relationship to chromatin loop formation. CTCF protein appears as a ... or a weaker architectural role in chromatin loop formation. TAD borders directly impact on chromatin dynamics by restricting ... contacts within specific genomic portions thus confining chromatin loop formation within TADs. We discuss how sub-TAD chromatin ... such rosette-like structures are usually represented as a 2D projection taking the form of the chromatin loops classically ...
Rosette formation in non Hodgkins lymphoma in the bone marrow - A case report. Kurien, A., Manohar, C., Mathew, M. & Rao, L., ... Rosettes in idiopathic thrombocytopenic purpura - An unusual observation. Mathew, M. & Goel, G., 01-12-2009, In: Internet ... Rosette-forming glioneuronal tumor - Evidence of stem cell origin with biphenotypic differentiation. Chakraborti, S., Mahadevan ...
Results: Rosette formation was observed in 46.8% (75/160) of the parasite isolates from all the blood groups tested. Rosettes ... while the mean rosette frequency was higher in isolates from patients with blood group A (28.7). Rosette formation correlated ... Host blood group antigens and two serum proteins α2-macroglobulin (α2M) and IgM have been implicated in rosette formation in ... falciparum parasite rosette formation was affected by blood group type and plasma concentration of IgM. A lower IgM ...
Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and ... May modulate the formation of a collagenous extracellular matrix.. Gene Name:. LOXL4. Uniprot ID:. Q8MJ24 Molecular weight:. ... Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by ... May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and ...
At Hegras Jabal al Ahmar and Jabal al Banat, immense sandstone formations with several impressive tombs carved into them, ... Abdur points out Roman rosettes, griffins, urns, lions, sphinxes, and even a snake-headed woman he claims is a primitive ... pointing out different rocky formations linked to the narrative. As we clamber into our green vintage Land Rover to make our ...
Rosette Formation E5.478.810 E1.450.495.706. E5.478.594.730. Ryanodine D2.455.849.291.686. Sagittal Sinus Thrombosis C10.228. ...
... Specializes in Quality Crystals, Minerals & Stones. Shop with confidence as we blend science with unlimited spiritual and energy possibilities.
Rosette Formation. *Serologic Tests. *Serotyping. *Skin Tests. Below are MeSH descriptors whose meaning is more specific than " ...
This plant has long, narrow leaves that grow in a rosette formation. The Japanese Spider Plant is easy to care for and can ...
Sand becomes embedded in Selenite blades, while additions of water overtime help form the signature "rosette" formation. Desert ...
December 1993 microscope photo provided by the National Cancer Institute shows a typical neuroblastoma with rosette formation. ...
Having said that, pluripotent cells have to have not be current for tumor formation. Such as, smaller rosette like tu mors can ... A single important concern with all the use of pluripotent stem cells in cell therapy is the fear of tumor formation. We did ... not observe any teratoma formation and this was possible due the lack of residual pluripotent cells in our cultures. ...
The Parva can reach heights up to 1-1.5 feet tall (30-61 cm) and tends to grow in small rosette formations. ... Some versions of the Sansevieria Kirkii have broad leaves with harsh and ragged edges that form small ground-dwelling rosettes. ... At maturity, they generally dont grow beyond 2 feet (60 cm). Their growth pattern follows the rosette patterns, like a ... Unlike typical Sansevieria plants, like the Trifasciata, the Francisii develops in a rosette pattern. Slowly but surely, ...
Inclusion of IAA within the regeneration medium resulted in callus formation at the cut ends of explants, formation of rosette ... limited thanks to the formation of ill-formed buds or shoot-like structures which either resist elongation or produce rosettes ...
... part with rosette formation, infiltrative between the connective tissue and a large area of necrosis. These cells conform to a ... The formation of circulating heparin-platelet factor-4 (PF4) complexes have been observed in heparin-induced thrombocytopenia ( ... However, atherosclerosis is not a risk factor for the formation of PF4-heparin complex in HIT. ... tuberculosis infection and plays a role in granuloma formation, determines the pathogen’s invasion, its severity, and ...
The famous Ballard rosette constellation is another name of Walker Delta constellation, where it uses a different notation. ... Walker Delta constellation is the most common formation for constellations. It is defined as a bunch of circular orbits with a ...
  • It consists of variably extensive focal infoldings or rosette-like formations of the retinal layers, sometimes with poorly developed or disorganized architecture. (nih.gov)
  • There are focal infoldings or rosette-like formations of the retinal layers (arrow). (nih.gov)
  • It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. (nih.gov)
  • 15. Enumeration and isolation of human T and B lymphocytes by rosette formation with antibody-coated erythrocytes. (nih.gov)
  • 16. Separation and properties of EA-rosette-forming lymphocytes in humans. (nih.gov)
  • showed that Cdc42 activity needs to be suppressed in boundary cells for them to become epithelial, which is critical for the formation of distinct morphological boundaries between somitomeres. (frontiersin.org)
  • D. Regulatory network in epithelial rosettes. (nih.gov)
  • Micro-patterned substrate tech allows for single neural rosette formation. (wisc.edu)
  • 2D neural rosettes grown in cell culture. (wisc.edu)
  • The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). (nih.gov)
  • Rosette formations of crystal clusters bringing thoughts to a rose as a symbol of life. (trollbeads.mu)
  • 13. Rosette-formation with mouse erythrocytes. (nih.gov)
  • Resident bone marrow macrophages (RBMM), which are physically associated with immature, proliferating hematopoietic cells in vivo, formed striking rosettes with unopsonized sheep erythrocytes (E) in vitro, unlike resident peritoneal macrophages (RPM). (silverchair.com)
  • The diffuse mononuclear infiltration of the liver tissue was found to consist of 90% E-rosette-forming cells. (nih.gov)
  • You can identify these young edible weeds with leaves that grow low to the ground, in a rosette formation. (minnetonkaorchards.com)
  • This plant has long, narrow leaves that grow in a rosette formation. (indoorhomegarden.com)
  • The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)
  • blood parasites, which included a tetrad formation in the shape of a rosette (A), and a hooked, intraerythrocytic form (B). (cdc.gov)
  • Sand becomes embedded in Selenite blades, while additions of water overtime help form the signature "rosette" formation. (rareearthmercantile.com)
  • Some versions of the Sansevieria Kirkii have broad leaves with harsh and ragged edges that form small ground-dwelling rosettes. (gardenbenchtop.com)
  • in aged rats, we even found rosette-like structure formation. (nih.gov)
  • Rosette formation can be used to identify specific populations of these cells. (nih.gov)
  • A single important concern with all the use of pluripotent stem cells in cell therapy is the fear of tumor formation. (liverx-receptor.com)
  • We did not observe any teratoma formation and this was possible due the lack of residual pluripotent cells in our cultures. (liverx-receptor.com)
  • Having said that, pluripotent cells have to have not be current for tumor formation. (liverx-receptor.com)
  • Their growth pattern follows the rosette patterns, like a beautiful flower. (gardenbenchtop.com)
  • Unlike typical Sansevieria plants, like the Trifasciata , the Francisii develops in a rosette pattern. (gardenbenchtop.com)
  • The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. (nih.gov)
  • TAD borders directly impact on chromatin dynamics by restricting contacts within specific genomic portions thus confining chromatin loop formation within TADs. (mdpi.com)
  • The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. (bvsalud.org)
  • The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). (bvsalud.org)
  • blood parasites, which included a tetrad formation in the shape of a rosette (A), and a hooked, intraerythrocytic form (B). (cdc.gov)