The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
Salts and esters of gentisic acid.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.
A plant genus of the family ERICACEAE. The common name of "wintergreen" is also used for PYROLA and "snowberry" is also used for SYMPHORICARPOS.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Family of retrovirus-associated DNA sequences (v-rel) originally isolated from an avian reticuloendotheliosis virus strain. The proto-oncogene rel (c-rel) codes for a subcellular (nuclear and cytoplasmic) transcription factor that has a role in lymphocyte differentiation. Translocation or overexpression of c-rel or competition from v-rel causes oncogenesis. The human rel gene is located at 2p12-13 on the short arm of chromosome 2.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Eighteen-carbon cyclopentyl polyunsaturated fatty acids derived from ALPHA-LINOLENIC ACID via an oxidative pathway analogous to the EICOSANOIDS in animals. Biosynthesis is inhibited by SALICYLATES. A key member, jasmonic acid of PLANTS, plays a similar role to ARACHIDONIC ACID in animals.
A group of alicyclic hydrocarbons with the general formula R-C5H9.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
Diseases of plants.
A family of POTASSIUM and SODIUM-dependent acidic amino acid transporters that demonstrate a high affinity for GLUTAMIC ACID and ASPARTIC ACID. Several variants of this system are found in neuronal tissue.
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
A glial type glutamate plasma membrane transporter protein found predominately in ASTROCYTES. It is also expressed in HEART and SKELETAL MUSCLE and in the PLACENTA.
The ability of the BRAIN to suppress neuronal responses to external sensory inputs, such as auditory and visual stimuli. Sensory filtering (or gating) allows humans to block out irrelevant, meaningless, or redundant stimuli.
... for business and industry The effect of salicylates on experimental arthritis in rabbits The physician and prohibition The rôle ... The Rôle of Alcohol in the Welfare of the Human Race: From the Standpoint of Pharmacology and Therapeutics. Chicago: American ... The Effect of Salicylates on Experimental Arthritis in Rabbits. Chicago: American Medical Association, 1917. Fantus, Bernard. ...
Grigorov B, Attuil-Audenis V, Perugi F, Nedelec M, Watson S, Pique C, Darlix JL, Conjeaud H, Muriaux D (2009). "A role for CD81 ... Benzyl salicylate and terfenadine have been shown to bind to CD81. Cluster of differentiation GRCh38: Ensembl release 89: ... CD81 appears to play a role in the pathogenesis of influenza. CD81 has been shown to interact with TSPAN4, CD19, CD9, PTGFRN, ... This protein plays a critical role in Hepatitis C attachment and/or cell entry by interacting with virus' E1/E2 glycoproteins ...
Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM (December 2004). "Treatment of acute Kawasaki disease: aspirin's role in ... Salicylate therapy, particularly aspirin, remains an important part of the treatment (though questioned by some) but ... There is limited evidence to indicate whether children should continue to receive salicylate as part of their treatment. ... Kitamura S (December 2002). "The role of coronary bypass operation on children with Kawasaki disease" (PDF). Coronary Artery ...
It is an important player in plant immunity, although its role is still not fully understood by scientists.[70] They are ... One of the most common drugs derived from salicylates is aspirin, also known as acetylsalicylic acid, with anti-inflammatory ... They also play an active role in the suppression of cell proliferation.[63] They have the ability to induce death in ... natural products still play a major role as starting material for drug discovery.[51] A 2007 report[52] found that of the 974 ...
... likely plays a role in migraine development at a biochemical level, but the role of oral magnesium supplementation in ... Magnesium borate, magnesium salicylate, and magnesium sulfate are used as antiseptics. Magnesium bromide is used as a mild ... There is limited evidence that magnesium supplementation may play a role in the prevention and treatment of migraine. Sorted by ...
February 2005). "Catabolic role of a three-component salicylate oxygenase from Sphingomonas yanoikuyae B1 in polycyclic ...
This hydrolysis reaction occurs in the plant, catalyzed by methyl salicylate esterase. Pesticides are required to seek ... not directly toxic to the fungus but instead activates the natural defences of the crop in a manner similar to the known role ...
More recently, another role of SLs was identified in the inhibition of shoot branching. This discovery of the role of SLs in ... Like MeJA, methyl salicylate is volatile and can act as a long-distance signal to neighboring plants to warn of pathogen attack ... In addition to their role in defense, JAs are also believed to play roles in seed germination, the storage of protein in seeds ... Since it was found in freshly abscissed leaves, it was initially thought to play a role in the processes of natural leaf drop, ...
... so may need to adopt a low-salicylate diet. Salicylic acid is a phenolic phytohormone, and is found in plants with roles in ... Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) ... Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used ... Methyl salicylate is taken up by the stomata of the nearby plant, where it can induce an immune response after being converted ...
... like salicylate and valproate, cause MPT. MPT may also play a role in mitochondrial autophagy. Cells exposed to toxic amounts ... MPT also appears to play a key role in damage caused by ischemia, as occurs in a heart attack and stroke. However, research has ... Bernardi, P; Di Lisa, F (2015). "The mitochondrial permeability transition pore: molecular nature and role as a target in ... Varanyuwatana, P.; Halestrap, A. P. (2012). "The roles of phosphate and the phosphate carrier in the mitochondrial permeability ...
When treating the primary cause, pain management may still play a role in treatment. The extent of its role varies depending on ... Another topical option is an arthritis cream containing the ingredient, methyl salicylate (Bengay). Myalgia "Arthralgia ...
... s also play a crucial role in glycan-protein interactions. In plants, the shikimate pathway first leads to ... such as the hormones salicylate and auxin. This pathway contains enzymes that can be regulated by inhibitors, which can cease ... Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals". Frontiers in ...
Studies evaluating the role of crypsis on herbivory measure leaf quality, such as nitrogen and protein levels, water content, ... salicylic acid and methyl salicylate. With the mistletoe, a possible line of study could be measuring nitrogen level change ... It plays an important role in the evolution of many organisms. It is hypothesized that transfer is conducted through a vector ... They could also play a role in the conversion of a volatile signal to a chemical product response e.g. ...
Salicylate medicines-including salicin, salicylic acid, and sodium salicylate- were difficult and wasteful to extract from ... After World War II, with the IG Farben conglomerate dismantled because of its central role in the Nazi regime, Sterling ... The major turning point for salicylate medicines came in 1763, when a letter from English chaplain Edward Stone was read at a ... Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers ...
小部分人服用阿司匹林後會產生類似於過敏的反應,如蕁麻疹、水腫和頭痛。這種反應是由於水楊酸不耐受(英語:salicylate intolerance),並不是真正的過敏,而是連一點點水楊酸都無法代謝所導致的藥物過量。 ... 凝血因子XII缺乏症(英語:Factor_XII#Role_in_disease). 無影響. 延長. 無影響.
... also known as salicylate intolerance), even small doses of salicylate can cause adverse reactions. Specifically, salicylate ... NF-κB is a transcription factor complex that plays a central role in many biological processes, including inflammation. ... Salicylate sensitivity differs from salicylism, which occurs when an individual takes an overdose of salicylates. Salicylate ... People with salicylate intolerance are unable to consume a normal amount of salicylate without adverse effects.[citation needed ...
... and the role of salicylates and corticosteroids in cell signaling and adhesion (NF-κB and MAP kinases of MAPK3, MAPK1, and ...
This may play an important role in the pathogenesis of the central component of thyroid allostasis in critical illness, tumors ... Other drugs such as estrogen, contraceptives, salicylates, and phenytoin can alter the binding of TBG to TH, resulting in ... uremia and starvation (TACITUS). In addition, both illness and medication (e.g. salicylates and heparin) may impair plasma ...
... leaving the product salicylate. Salicylate is an aromatic compound found in species from both the plant and bacterial kingdoms ... implications for transition state stabilization and the role of lysine 42". Biochemistry. 50 (33): 7198-207. doi:10.1021/ ... Salicylate can also be found in various species of plants, where it is used for flowering and resistance against pathogen ... More specifically, IPL will use isochorismate as a substrate and convert it into salicylate and pyruvate. IPL is a PchB enzyme ...
Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate.[117][ ... Thun MJ, Jacobs EJ, Patrono C (April 2012). "The role of aspirin in cancer prevention". Nature Reviews. Clinical Oncology. 9 (5 ... Done AK (November 1960). "Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ... Aspirin should not be taken by people who are allergic to ibuprofen or naproxen,[86][87] or who have salicylate intolerance[88] ...
Biodiversity plays vital roles in maintaining human and animal health. A wide variety of plants, animals and fungi are used as ... methyl salicylate and quinine. Streptomycin, neomycin, and erythromycin are derived from tropical soil fungi. A lot of plant ...
Salicylic acid plays a role in the resistance to pathogens by inducing the production of pathogenesis-related proteins. Many ... Useful stressors include an actual infection or simply defense signals such as salicylate and methyl jasmonate. The proteins ...
The large doses (6-8 grams) of sodium salicylate that were used to treat arthritis commonly irritated the stomach lining and ... Finally, he claimed that Hoffmann's role was restricted to the initial lab synthesis using his (Eichengrün's) process and ... saying that his father had complained about the bitter taste of sodium salicylate, the only drug then available to treat ... a compound that shared the therapeutic properties of other salicylates but not the strong acidity that he believed caused ...
The role of class I receptor in cell-mediated programmed cell (enterocyte) death is not known. These proteins are called MHC ... This can be the case with ω5-gliadin allergy with salicylate sensitivity. There is no clear reasoning, either from genetics or ... There has been some suggestion wheat plays a role in juvenile diabetes as antibodies to the non-glutinous seed storage glb-1 (a ... Innate immunity to gluten is complicated by an apparent role gluten has in bypassing normal host defense and peptide exclusion ...
... where it plays a role in the induction of resistance. Methyl salicylate is believed to function by being metabolized to the ... Salicylate, the major metabolite of methyl salicylate, may accumulate in blood, plasma or serum to confirm a diagnosis of ... Methyl salicylate is potentially deadly, especially for young children. A single teaspoon (5 ml) of methyl salicylate contains ... Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized ...
Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate. Aspirin ... Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E (February 2017). "The role of aspirin dose on the prevention ... Done AK (November 1960). "Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ... Plasma salicylate levels in general range from 30 to 100 mg/l after usual therapeutic doses, 50-300 mg/l in people taking high ...
... lead salicylate, lead stearate, lead 2-ethylhexoate, copper salicylate, copper stearate, lithium fluoride, n-butyl ferrocene, ... Perchlorates and chlorates play this role together with their main use as oxidizers. Chlorine donors are often used also in ... often used in whistle mixes together with potassium perchlorate Sodium salicylate - used in some whistle mixes Gallic acid - ...
McCullough, Michael; Farah, C.S. (December 2008). "The role of alcohol in oral carcinogenesis with particular reference to ... methyl salicylate, and thymol (its exact composition is a trade secret). Lawrence named his antiseptic "Listerine" in honor of ... methyl salicylate (wintergreen) 0.06%, and eucalyptol (eucalyptus) 0.092%. In combination all have an antiseptic effect and ... "Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain". BMJ ...
AtPEP 1 interaction with PEPR 1 activates the defense genes that regulates jasmonate/ethylene and salicylate defense hormones ... which is known to play an important role in plant innate immune system. Further, ethylene can enhance DAMP triggered immunity. ... an 18 residues peptide which plays critical role in defense signal and induced in response to wounding, jasmonate and ethylene ... receptor kinase that play critical roles in plant innate immunity. Plants have evolved intricate immunity mechanism to combat ...
The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies ... encoded search term (What is the role of salicylates in the etiology of Reye syndrome?) and What is the role of salicylates in ... What is the role of salicylates in the etiology of Reye syndrome?. Updated: Apr 02, 2018 ... component of the enzyme as the target of salicylate inhibition. [3] Absence of inhibition of beta-oxidation by salicylates in ...
The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies ... What is the role of salicylates in the etiology of Reye syndrome?. Updated: Apr 02, 2018 ... component of the enzyme as the target of salicylate inhibition. [3] Absence of inhibition of beta-oxidation by salicylates in ... 1] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and ...
Carbazochrome salicylate (CS) (Adrenosem®, S.E. Messengill Co., Bristol, Tennessee) was tried in aspirin-induced gastric ... Carbazochrome salicylate and its role in aspirin-induced gastric irritation in rats. *Jagdish C. Mangla MD, FRCP(C), FACP. 1,2 ... Mangla, J.C., Kim, Y. & Desbaillets, L.G. Carbazochrome salicylate and its role in aspirin-induced gastric irritation in rats. ... Carbazochrome salicylate (CS) (Adrenosem®, S.E. Messengill Co., Bristol, Tennessee) was tried in aspirin-induced gastric ...
To determine the role of C-Rel in nitric-oxide synthase-2 (NOS-2) transcriptional activation, we evaluated the effect of ... Essential role of C-Rel in nitric-oxide synthase-2 transcriptional activation: time-dependent control by salicylate Mol ... A single dose of salicylate did not inhibit C-Rel binding at any time point. The addition of a second dose of salicylate 4 h ... A single dose of salicylate added with LPS/IFNgamma inhibited NOS-2 expression only at 4 h. However, salicylate supplement ...
We have therefore used a well characterized model of COX-2 induction in human cells (20) to establish the role of NF-κB and ... In particular, sodium salicylate is a very weak inhibitor of COX-1 or COX-2 (10) activity in vitro. However, sodium salicylate ... How, then, does sodium salicylate inhibit the synthesis of COX-2 metabolites? We found that sodium salicylate produced ... in the presence or absence of 100 μg/ml sodium salicylate (plus sodium salicylate) for 6 hr before DNA extraction and ...
Role of Arachidonic Acid. Jane A. Mitchell, Michael Saunders, Peter J. Barnes, Robert Newton and Maria G. Belvisi ... Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1β for 24 hr with an IC50 value of 5 ... Thus, sodium salicylate is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB ... Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence ...
The role of natural salicylates in food intolerance by Anne Swain at the Allergy Unit at Royal Prince Alfred Hospital, Sydney, ... The role of natural salicylates in food intolerance. by. Anne R Swain. Doctor of Philosophy (PhD), The University of Sydney. ... were constructed which could be used by salicylate-sensitive individuals to control the total daily dose of salicylate consumed ... Overall, natural salicylates are the single commonest substance to produce reactions when tested by double-blind oral challenge ...
Many studies suggest that nutrition plays a role in this common disorder. ... Eliminating Salicylates and Food Additives. By accident, an allergist named Dr. Feingold discovered that food could affect ... Omega-3 fatty acids play important roles in the brain.. Children with ADHD generally have lower levels of omega-3 fatty acids ... The exact cause of ADHD is unclear, but research shows that genetics play a major role. Other factors, such as environmental ...
Infusion of sodium salicylate (50.0 or 100.0 μg/μl) into the ventral septal area (VSA) of the rat brain suppressed ... I. Effects of salicylate and role of cyclic AMP. Neuropharmacology 14:397-403Google Scholar ... salicylate alone). These results are consistent with the notion that sodium salicylate infusions within the VSA enhance AVP ... hyperthermia was not due to a hypothermic action of salicylate since salicylate infusions given during cold exposure (10.0°C) ...
Essential Role of C-Rel in Nitric-Oxide Synthase-2 Transcriptional Activation: Time-Dependent Control by Salicylate ... Calcium salicylate-mediated apoptosis in human HT-1080 fibrosarcoma cells. J. G. Mahdi, M. A. Alkarrawi, A. J. Mahdi, I. D. ... Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6kand Down-regulation of c-Myc, Cyclin D1, Cyclin A, and ... Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-κB activation in Rat ventricular ...
Does the available research support a role for natural salicylates in any disease causation?. As discussed above, there is no ... Salicylate elimination or "low salicylate" diets - which remove foods deemed to contain natural salicylates - can be ... One disease where the role of natural salicylates has been studied in more detail is aspirin-sensitive asthma, where doses of ... What is the evidence supporting the role of low salicylate diets for these indications?. We reviewed the literature using ...
Overall, this study delineates the roles of Lon protease, its substrate MarA and downstream targets of MarA, e.g. acrB and tolC ... This study addresses the roles of Lon, a major ATP-dependent protease, in modulating the responses of Escherichia coli strain ... f Roles of Lon protease and its substrate MarA during sodium salicylate-mediated growth reduction and antibiotic resistance in ... Roles of Lon protease and its substrate MarA during sodium salicylate-mediated growth reduction and antibiotic resistance in ...
These three signals play important roles in induced resistance as well. SA is a key regulator of pathogen-induced systemic ... Differential effectiveness of salicylate-dependent and jasmonate/ethylene-dependent induced resistance in Arabidopsis.. Ton J1 ...
Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal ... METHYL SALICYLATE (UNII: LAV5U5022Y) (SALICYLIC ACID - UNII:O414PZ4LPZ) METHYL SALICYLATE. 250 mg in 1 mL. ... capsaicin 0.025 % / menthol 6 % / methyl salicylate 25 % Topical Solution. PSN. 4. 1989491. capsaicin 0.25 MG/ML / menthol 60 ... DFS 75MG DR/MS 25%/MENTH 6%/CAP 0.025% PAK- diclofenac sodium, methyl salicylate, menthol, capsaicin kit. If this SPL contains ...
... DSpace/Manakin ... Cross talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways plays an important role in the regulation and ... suggesting that SA-mediated redox modulation plays an important role in the SA-mediated attenuation of the JA signaling pathway ...
... methyl salicylate; EB, ethyl benzoate; Benz, benzaldehyde; MCH, 4-methylcyclohexanol; Lin, linalool. ACV, apple cider vinegar ... Differential Role for a Defined Lateral Horn Neuron Subset in Naïve Odor Valence in Drosophila. *Hadas Lerner1. , ... Essential Role of the Mmushroom Body in Context-Dependent CO2 Avoidance in Drosophila. Curr. Biol. 23, 1228-1234 (2013). ... There is now evidence that the MB also plays a role in some innate olfactory behaviors, mostly attractive12,13,14, while the LH ...
Malakar 2014: Minding the greens - Role of dietary salicylates in common behavioural health conditions. Posted on May 24, 2016 ... Some Non-Salicylate fruits acceptable on Stage One of the Feingold Program. To get more information, click on picture or see ... that Feingold hypothesis is still the central theoretical edifice when it comes to explaining the possible role of salicylates ... "Given that it is now well-known that autistic patients tend to be PST-deficient, causal link between a low-salicylate diet and ...
Salicylate caused greater auditory threshold shifts (near 15 dB) in GLAST KO mice than in wild-type mice across all tested ... We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. Using ... Salicylate caused greater auditory threshold shifts (near 15 d... ... we found that disruption of gap detection by salicylate was ... we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32 kHz narrow band ...
The interaction between sodium salicylate and a GABAB receptor antagonist had a relatively late start, and the duration of this ... Furthermore, we studied how the responses were affected by combined local application of sodium salicylate and an agonists/ ... Our results indicate that sodium salicylate can affect sound-driven activity in the ICd by modulating local GABAergic ... The synergistic interaction between sodium salicylate and a GABAA receptor antagonist had a relatively early start in reference ...
Her thesis, "The Role of Natural Salicylates in Food Intolerances," became a definitive work, launching others to do further ... This may lead to the development of salicylate and other intolerances, as a result of leaky gut. Low-salicylate- and salicylate ... Urinary excretion of unchanged salicylate accounts for 10% of the total elimination of salicylate. Excretion of salicylate ... Salicylate Sensitivity: The Other Food Intolerance. Home / Autoimmune/Allergy Medicine / Salicylate Sensitivity: The Other Food ...
"Interaction between salicylate- and jasmonate-induced signal transduction pathways in the development of potato resistance to ... systemic induced resistance where JA plays an important role as an intermediate on conditions of active reg ... Interaction between salicylate- and jasmonate-induced signal transduction pathways in the... Sorokan, A.; Burkhanova, G.; ... Interaction between salicylate- and jasmonate-induced signal transduction pathways in the development of potato resistance to ...
It is an important player in plant immunity, although its role is still not fully understood by scientists.[70] They are ... One of the most common drugs derived from salicylates is aspirin, also known as acetylsalicylic acid, with anti-inflammatory ... They also play an active role in the suppression of cell proliferation.[63] They have the ability to induce death in ... natural products still play a major role as starting material for drug discovery.[51] A 2007 report[52] found that of the 974 ...
Eliminating Salicylates and Food Additives By accident, an allergist named Dr. Feingold discovered that food could affect ... Omega-3 fatty acids play important roles in the brain. Children with ADHD generally have lower levels of omega-3 fatty acids ... Nutrition plays a role in ADHD: Studies suggest that diet can have powerful effects on behavior ... The diet was free of salicylates, which are compounds found in many foods, medications and food additives. While on the diet, ...
Inflammation plays causal role in neurologic changes associated with Lyme disease About 15% of patients with Lyme disease ... Salicylates drugs reduce proliferation, viability of cultured vestibular schwannoma cells Researchers from Massachusetts Eye ... Needle electromyography can play a major role in face transplantation A recent study published in Muscle & Nerve appears to ... Computer-driven automated drill may play pivotal role in future surgeries A computer-driven automated drill, similar to those ...
Comprehensive disease interaction information for benzoic acid/hyoscyamine/methenamine/methylene blue/phenyl salicylate. ... Muther RS, Potter DM, Bennett WM "Aspirin-induced depression of glomerular filtration rate in normal humans: role of sodium ... Salicylate-induced hepatotoxicity appears to be dependent on serum salicylate concentration (, 25 mg/dL) and has occurred most ... Salicylate and its metabolites are eliminated almost entirely by the kidney. Therapy with salicylate drugs should be ...
Comprehensive disease interaction information for acetaminophen/caffeine/magnesium salicylate/phenyltoloxamine. Includes ... Clements JA, Critchley JA, Prescott LF "The role of sulphate conjugation in the metabolism and disposition of oral and ... Salicylate-induced hepatotoxicity appears to be dependent on serum salicylate concentration (, 25 mg/dL) and has occurred most ... Salicylate and its metabolites are eliminated almost entirely by the kidney. Therapy with salicylate drugs should be ...
A transcriptional profile of the E. coli response to NaSal.NaSal is a natural product with a role in signal transduction in the ... Genome-Wide Transcriptional Profiling of theEscherichia coli Responses to Superoxide Stress and Sodium Salicylate. Pablo J. ... Genome-Wide Transcriptional Profiling of theEscherichia coli Responses to Superoxide Stress and Sodium Salicylate ... Genome-Wide Transcriptional Profiling of theEscherichia coli Responses to Superoxide Stress and Sodium Salicylate ...
Role of food allergy in serous otitis media. Annals Allergy. 1994;73:215-219. *Perry CA, Dwyer J, Gelfand JA, Couris RR, ... Health effects of salicylates in foods adnd drugs. Nutr Rev. 1996;54(8):225-240. *Samartin S, Marcos A, Chandra RK. Food ... The role of your gastrointestinal tract, which includes your esophageal area, stomach, and your upper and lower intestinal ... There is much debate in the research literature over the role of oats, barley, and rye in a gluten-avoidance meal plan. ...
The Role of Salicylate in ADD/ADHD. July 26, 2013. 9 Ways to Respect Yourself and Honor Others. December 13, 2017 ... Imagine a huge upheaval in medicine that alters the whole way we look at disease, how our bodies work, the role of genes and ...
... where it plays a role in the induction of resistance. Methyl salicylate is believed to function by being metabolized to the ... Salicylate, the major metabolite of methyl salicylate, may accumulate in blood, plasma or serum to confirm a diagnosis of ... Methyl salicylate is potentially deadly, especially for young children. A single teaspoon (5 ml) of methyl salicylate contains ... Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized ...
  • Sodium salicylate inhibited prostaglandin E 2 release when added together with interleukin 1β for 24 hr with an IC 50 value of 5 μg/ml, an effect that was independent of NF-κB activation or COX-2 transcription or translation. (aspetjournals.org)
  • Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μ m exogenous arachidonic acid. (aspetjournals.org)
  • Thus, sodium salicylate is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/ml) activation and is easily displaced by arachidonic acid. (aspetjournals.org)
  • In 1971, Vane ( 3 ) demonstrated that a range of NSAIDs, including acetylsalicylic acid and sodium salicylate, inhibited the enzyme COX. (aspetjournals.org)
  • Infusion of sodium salicylate (50.0 or 100.0 μg/μl) into the ventral septal area (VSA) of the rat brain suppressed Prostaglandin-E 1 -induced hyperthermia. (springer.com)
  • These results are consistent with the notion that sodium salicylate infusions within the VSA enhance AVP action and thus bring about the attenuation of PGE-induced hyperthermia. (springer.com)
  • Alexander SJ, Cooper KE, Veale WL (1987) Blockade of prosta-glandin E 1 hyperthermia by sodium salicylate given into the ventral septal area of the rat brain. (springer.com)
  • Cranston WI, Rawlins MD (1972) Effects of intracerebral microinjection of sodium salicylate on temperature regulation in the rabbit. (springer.com)
  • Hori T, Nakashima T, Kiyohara T, Shibata M (1984) Effects of leukocytic pyrogen and sodium salicylate on hypothalamic neurons in vitro. (springer.com)
  • This study addresses the roles of Lon, a major ATP-dependent protease, in modulating the responses of Escherichia coli strain MG1655 to low and high amounts of sodium salicyclate (NaSal), a widely used clinically relevant analgesic. (microbiologyresearch.org)
  • Sodium salicylate (SS) is a widely used medication with side effects on hearing. (frontiersin.org)
  • In order to probe the extent of these regulatory networks, we have measured whole-genome transcriptional profiles of the E. coli response to the superoxide-generating agent paraquat (PQ), an inducer of the soxRS system, and to the weak acid salt sodium salicylate (NaSal), an inducer of the marRA system. (asm.org)
  • Sodium Salicylate has analgesic, anti-inflammatory and antipyretic action. (intekom.com)
  • The principal use of Sodium Salicylate is in the treatment of acute rheumatic fever. (intekom.com)
  • Sodium salicylate is contra-indicated in the presence of severe renal disease. (intekom.com)
  • Sodium Salicylate is a gastric irritant and sodium bicarbonate is often given with it to reduce this effect (however the bicarbonate also increases rate of excretion and this lowers the concentration of salicylate in the blood). (intekom.com)
  • Patients suffering from severe intoxication (a plasma-salicylate concentration above 500 mg/mL in adults or 300 mg/mL in children) should be given gastric lavage together with forced diuresis by I/V infusions of saline with sodium bicarbonate or of compound sodium lactate injection or dextrose solution. (intekom.com)
  • We assessed insulin responses in all arterial segments, including aorta, distal saphenous artery and the microvasculature, as well as the metabolic insulin responses in muscle in rats fed on a high-fat diet (HFD) for various durations ranging from 3 days to 4 weeks with or without sodium salicylate treatment. (portlandpress.com)
  • [6] [7] In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. (wikipedia.org)
  • Systemic administration of sodium salicylate, a drug known to induce tinnitus, resulted in a doubling of spontaneous activity in the IC. (bl.uk)
  • We have therefore used a well characterized model of COX-2 induction in human cells ( 20 ) to establish the role of NF-κB and exogenous arachidonic acid in the ability of salicylic acid to effectively inhibit COX-2 activity in vitro . (aspetjournals.org)
  • Cross talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways plays an important role in the regulation and fine tuning of induced defenses that are activated upon pathogen or insect attack. (uu.nl)
  • Methyl salicylate was first isolated (from the plant Gaultheria procumbens) in 1843 by the French chemist Auguste André Thomas Cahours (1813-1891), who identified it as an ester of salicylic acid and methanol. (wikipedia.org)
  • Methyl salicylate is believed to function by being metabolized to the plant hormone salicylic acid. (wikipedia.org)
  • Methyl salicylate can be produced by esterifying salicylic acid with methanol. (wikipedia.org)
  • However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID. (wikipedia.org)
  • Methyl salicylate (MeSA), a molecule that can be converted to salicylic acid (SA), is an essential signal for establishing SAR, particularly under a short period of exposure to light after pathogen infection. (plantphysiol.org)
  • Silverman P., Linzer R.A., Raskin I. (1993) The Role of Salicylic Acid as a Plant Signal Molecule. (springer.com)
  • Salicylic acid (SA) plays an important role in regulating plant defense responses against pathogens. (usda.gov)
  • The salts and esters of salicylic acid are known as salicylates. (wikipedia.org)
  • Salicylates should be used with caution in patients with renal impairment and with extreme caution, if at all, in patients with advanced, chronic renal failure, as salicylic acid and its metabolites are excreted in the urine (see Pharmacokinetics). (pdr.net)
  • AIM: To examine sera for the presence of salicylic acid and 2,3- and 2,5-dihydroxybenzoic acids (2,3- and 2,5-DHBA), in individuals not taking salicylate drugs. (bmj.com)
  • Serum samples (some spiked with salicylic acid) were incubated with salicylate hydroxylase and analyses undertaken. (bmj.com)
  • One hub of the defense networks is centered on salicylic acid (SA), which plays a key role in activating disease resistance in plants. (ebscohost.com)
  • Examines the role of salicylic acid (SA) in regulating cell death and defense-related response using the accelerated cell death 5 genetic mutant in Arabidopsis. (ebscohost.com)
  • Phytohormone crosstalk is crucial for plant defenses against pathogens and insects in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. (eurekaselect.com)
  • The association of Reye syndrome with salicylates, particularly aspirin, was demonstrated in several epidemiologic studies around the world. (medscape.com)
  • [ 18 ] Some have postulated that salicylates stimulate the expression of inducible nitric oxide synthase (iNOS) because of the findings of iNOS stimulation in African children with fatal malaria, a disease that causes symptoms similar to those of Reye syndrome and is often treated with aspirin. (medscape.com)
  • Recognition of the structural similarity between aspirin metabolites and enzyme substrates for the mitochondrial trifunctional enzyme important in beta-oxidation led to identification of the long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) component of the enzyme as the target of salicylate inhibition. (medscape.com)
  • Carbazochrome salicylate (CS) (Adrenosem ® , S.E. Messengill Co., Bristol, Tennessee) was tried in aspirin-induced gastric mucosal injury in rats because of the manufacturer's claim that it stops bleeding by its action on capillary permeability. (springer.com)
  • Brodie DA, Chase BJ: Role of gastric acid in aspirin-induced gastric irritation in the rat. (springer.com)
  • Mangla, J.C., Kim, Y. & Desbaillets, L.G. Carbazochrome salicylate and its role in aspirin-induced gastric irritation in rats. (springer.com)
  • To improve the original preparations, salicylate was acetylated, yielding acetylsalicylic acid, also known as aspirin ( 1 ). (aspetjournals.org)
  • The initial clinical experience in 76 patients indicated that natural salicylates (aspirin) were one of the main groups of compounds which could precipitate recurrent idiopathic urticaria/angioedema, however, the literature revealed that published information about their presence in food was limited. (nsw.gov.au)
  • A single teaspoon (5 ml) of methyl salicylate contains approximately 6 g of salicylate, which is equivalent to almost twenty 300 mg aspirin tablets (5 ml × 1.174 g/ml = 5.87 g). (wikipedia.org)
  • Other over-the-counter medications may also contain salicylates similar to those found in aspirin. (healthline.com)
  • Aspirin (and salicylates) has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chicken pox and influenza. (intekom.com)
  • Pepto-Bismol should not be used by patients hypersensitive to Aspirin or other salicylates. (medicines.org.uk)
  • Do not take with aspirin or other salicylates. (medicines.org.uk)
  • Together researchers Goldfine and Shoelson focussed their study on salsalate, which is a salicylate similar to aspirin. (medindia.net)
  • Now it is very interesting because aspirin is acetylsalicylate and salicylate is found in nature in fruits and vegetable. (ecancer.org)
  • So, we eat salicylate or a form of natural aspirin through our diet. (ecancer.org)
  • The best known salicylate is aspirin (acetylsalicylic acid), which was originally extracted from willow bark. (fedup.com.au)
  • Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C6H4(OH)(CO2CH3). (wikipedia.org)
  • The biosynthesis of methyl salicylate arises via the hydroxylation of benzoic acid by a cytochrome P450 followed by methylation by a methylase enzyme. (wikipedia.org)
  • Many plants produce methyl salicylate in small quantities. (wikipedia.org)
  • Methyl salicylate levels are often upregulated in response to biotic stress, especially infection by pathogens, where it plays a role in the induction of resistance. (wikipedia.org)
  • Since methyl salicylate is volatile, these signals can spread through the air to distal parts of the same plant or even to neighboring plants, whereupon they can function as a mechanism of plant-plant communication, "warning" neighbors of danger. (wikipedia.org)
  • Methyl salicylate is also released in some plants when they are damaged by herbivorous insects, where they may function as a cue aiding in the recruitment of predators. (wikipedia.org)
  • Some plants produce methyl salicylate in larger quantities, where it likely involved in direct defense against predators or pathogens. (wikipedia.org)
  • Methyl salicylate can also be a component of floral scents, especially in plants dependent on nocturnal pollinators like moths, scarab beetles, and (nocturnal) bees. (wikipedia.org)
  • Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or wintergreen). (wikipedia.org)
  • Methyl salicylate is used in high concentrations as a rubefacient and analgesic in deep heating liniments (such as Bengay) to treat joint and muscular pain. (wikipedia.org)
  • Methyl salicylate is used in low concentrations (0.04% and under) as a flavoring agent in chewing gum and mints. (wikipedia.org)
  • citation needed] Methyl salicylate is also used as a bait for attracting male orchid bees for study, which apparently gather the chemical to synthesize pheromones, and to clear plant or animal tissue samples of color, and as such is useful for microscopy and immunohistochemistry when excess pigments obscure structures or block light in the tissue being examined. (wikipedia.org)
  • It has also been discovered that methyl salicylate works as a kairomone that attracts some insects, such as the spotted lanternfly. (wikipedia.org)
  • Methyl salicylate is potentially deadly, especially for young children. (wikipedia.org)
  • Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers . (wikipedia.org)
  • SA and ROS are involved in methyl salicylate-induced programmed cell death in Arabidopsis thaliana. (ebscohost.com)
  • Previous studies show that methyl salicylate (MeSA) is a defense signal molecular. (ebscohost.com)
  • Salicylate is converted to catechol and gentisate by salicylate hydroxylase ( 4 , 6 ) and salicylate 5-hydroxylase ( 22 , 27 ), respectively. (asm.org)
  • In this study, we aimed to identify the salicylate hydroxylase in F. graminearum and determine its role in wheat head blight development. (usda.gov)
  • We initially identified a gene in F. graminearum strain NRRL 46422 that encodes a putative salicylate hydroxylase (designated FgShyC). (usda.gov)
  • Further genome sequence analyses resulted in the identification of eight salicylate hydroxylase candidates. (usda.gov)
  • Heterologous expression of FgShy1 in E. coli converted SA to catechol, confirming that FgShy1 is a salicylate hydroxylase. (usda.gov)
  • The glutathione biosynthesis inhibitor L-buthionine-sulfoximine strongly reduced PDF1.2 suppression by SA, suggesting that SA-mediated redox modulation plays an important role in the SA-mediated attenuation of the JA signaling pathway. (uu.nl)
  • Biosynthesis is inhibited by SALICYLATES. (harvard.edu)
  • A new salicylate synthase AmS is identified for siderophores biosynthesis in Amycolatopsis methanolica 239(T). (sigmaaldrich.com)
  • Salicylate synthase played a key role in the biosynthesis of some NRPS-derived siderophores by the providing of an iron coordination moiety as the initial building block. (sigmaaldrich.com)
  • A new salicylate synthase, namely AmS, was identified in the biosynthesis pathway of siderophore amychelin in Amycolatopsis methanolica 239(T), since it shunt chorismate, an integrant precursor, from primary to secondary metabolite flow. (sigmaaldrich.com)
  • The inhibition of salicylate biosynthesis, and hence, siderophore production is considered an attractive target for the development of novel antimicrobial agents. (ku.edu)
  • Recently, the identification of a cytokine-inducible isoform of COX, COX-2, has led to the suggestion that salicylate produces its anti-inflammatory actions by inhibiting COX-2 induction through actions on nuclear factor κB (NF-κB). (aspetjournals.org)
  • The anti-inflammatory properties of extracts from willow trees have been documented for almost 2000 years, and the active ingredient has been identified as salicylate. (aspetjournals.org)
  • The purpose of this study was to characterize diabetes progression in GK rats and to evaluate the potential role of the anti-inflammatory agent salsalate. (aspetjournals.org)
  • During the development of ARDS, excessive cytokine production plays a key role in the imbalance of pro- and anti-inflammatory responses, which destroys immune homeostasis and induces an inflammation cascade ( 8 ). (scielo.br)
  • : 69-75 In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. (wikipedia.org)
  • The salts, esters of salicylic acids, or salicylate esters of an organic acid. (curehunter.com)
  • As many as 10 to 25% of all children may be sensitive to salicylates. (clarksnutrition.com)
  • Research shows that about 20% of adults with asthma 1 , 60% with of people with food-induced itchy rashes, headaches or migraines, 70% of people with irritable bowel symptoms 2 and 75% of children with behaviour problems 3 may be sensitive to salicylates. (fedup.com.au)
  • In studies where markedly different levels of salicylates were investigated, a causative role for salicylates could be detected in some hyperactive children. (clarksnutrition.com)
  • High levels of salicylates are found in foods considered very good for you - does that surprise people? (fedup.com.au)
  • This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. (nih.gov)
  • Moreover, AmS converted chorismate to salicylate with K m of 129.05 μM, k cat of 2.20 min(-1) at optimal conditions, indicating its low substrate specificity and comparable velocity to reported counterparts (Irp9 and MbtI). (sigmaaldrich.com)
  • and Mycobacterium tuberculosis that convert chorismate to salicylate without requirement of an additional lyase such as PchB in P. aeruginosa. (ku.edu)
  • Infusion of artificial cerebrospinal fluid (aCSF) or 10.0 μg doses of salicylate did not. (springer.com)
  • Toxic ingestions of salicylates typically occur with doses of approximately 150 mg/kg body weight. (wikipedia.org)
  • Prolonged exposure to high doses of salicylates may cause hypokalemia due to both renal and extrarenal losses. (pdr.net)
  • Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. (nih.gov)
  • High doses of salicylates have recently been shown to inhibit IKKbeta activity and might therefore ameliorate insulin resistance and improve glucose tolerance in patients with type 2 diabetes. (nih.gov)
  • Using as a clue the blueberry/currant/honey jam episode provided by Ms B, I discovered that the common factor among her reactive foods was high salicylate content. (ndnr.com)
  • All "tolled," Ms B was on a very high-salicylate diet and supplement regimen. (ndnr.com)
  • Salicylate sensitivity varies - some people improve just by cutting down, some people have to avoid high salicylate foods, and some people are only affected by an overdose of salicylate medications. (fedup.com.au)
  • Overall, natural salicylates are the single commonest substance to produce reactions when tested by double-blind oral challenge. (nsw.gov.au)
  • A review of case notes from our Sydney-based paediatric allergy services, between 1 January 2003 and 31 December 2011, identified 74 children who had been prescribed diets that eliminated foods containing natural salicylates before attending our clinics. (mja.com.au)
  • Salicylate elimination or "low salicylate" diets - which remove foods deemed to contain natural salicylates - can be particularly restrictive, especially as they are often implemented with restriction of other foods such as those containing amines, glutamates, synthetic food additives, gluten and dairy. (mja.com.au)
  • Her thesis, "The Role of Natural Salicylates in Food Intolerances," became a definitive work, launching others to do further study on salicylate reactions. (ndnr.com)
  • Interaction between salicylate- and jasmonate-induced signal transduction pathways in the. (deepdyve.com)
  • Plants have evolved robust mechanisms to perceive and respond to diverse environmental stimuli.ᅠ The plant phytohormones jasmonates and salicylates play key roles in activating biotic stress response pathways. (rice.edu)
  • In contrast, although streptomycetes are saprophytic and known to play important roles in biotransformation and biodegradation in nature, the metabolic pathways have been little studied ( 7 , 26 , 32 ). (asm.org)
  • You-Xin Yang, Golam J. Ahammed, Caijun Wu, Shu-ying Fan and Yan-Hong Zhou, "Crosstalk among Jasmonate, Salicylate and Ethylene Signaling Pathways in Plant Disease and Immune Responses", Current Protein & Peptide Science (2015) 16: 450. (eurekaselect.com)
  • Indeed, the mechanisms by which different salicylates inhibit COX activity are unresolved. (aspetjournals.org)
  • [ 3 ] Absence of inhibition of beta-oxidation by salicylates in fibroblasts from patients with LCHAD deficiency substantiated the finding. (medscape.com)
  • There is evidence showing that GABAergic inhibition plays a major role in auditory responses in the IC ( 36 - 39 ) and SS can modulate GABAergic neurotransmission in the structure ( 34 ). (frontiersin.org)
  • However, the underlying mechanisms remained unclear.Methods:Salicylate-induced tinnitus-like behavior in rats was confirmed using gap prepulse inhibition of acoustic startle and prepulse inhibition testing, followed by comparison of the expression levels of BDNF, proBDNF, TrkB, CREB, and p-CREB. (deepdyve.com)
  • Lappas et al have recently reported that inhibition of NF-κB suppresses the release of proinflammatory cytokines from the human adipose tissue ex vivo, 12 suggesting the possible role of NF-κB in the adipose tissue. (ahajournals.org)
  • GABAergic synaptic inhibition is thought to play a critical role in olfactory processing in the antennal lobe and olfactory bulb. (jneurosci.org)
  • Differential effectiveness of salicylate-dependent and jasmonate/ethylene-dependent induced resistance in Arabidopsis. (nih.gov)
  • Although this type of food intolerance may not be currently "trending" with Ms B's friends, salicylate intolerance is not unknown in the medical literature. (ndnr.com)
  • Studies have shown that the salicylate activation by adenylation for incorporation to siderophores is associated with the growth and virulence of some pathogens. (ku.edu)
  • While this uncontrolled study does not prove a causal relationship between salicylate elimination diets and harm, the frequency of adverse events appears high, and in the absence of evidence of safety or efficacy, we cannot recommend the use of these diets in children. (mja.com.au)
  • Given that it is now well-known that autistic patients tend to be PST-deficient, causal link between a low-salicylate diet and the mitigation of symptom-severity seems a rather plausible hypothesis. (talkingaboutthescience.com)
  • New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, according to a study published in The American Journal of Pathology. (news-medical.net)
  • A single dose of salicylate did not inhibit C-Rel binding at any time point. (nih.gov)
  • To determine the role of C-Rel in nitric-oxide synthase-2 (NOS-2) transcriptional activation, we evaluated the effect of lipopolysaccharide and interferon-gamma (LPS/IFNgamma) on C-Rel DNA binding in RAW 264.7. (nih.gov)
  • This study presented AmS as a new cluster of salicylate synthase and the reaction mechanism and potential applications of salicylate synthase were highlighted as well. (sigmaaldrich.com)
  • In P. aeruginosa, salicylate is derived from chorismate via isochorismate by two enzymes: isochorismate synthase (PchA) and isochorismate-pyruvate lyase (IPL, PchB). (ku.edu)
  • Replacement of A375 by threonine, the corresponding residue in salicylate synthase, resulted in only residual ICS activity, indicating that A375 is not associated with the IPL-deficiency in PchA. (ku.edu)
  • A key member, jasmonic acid of PLANTS, plays a similar role to ARACHIDONIC ACID in animals. (harvard.edu)
  • This work (Paper IV) provides straightforward NMR evidence to show that the 2'-OH is intramolecularly hydrogen bonded with the vicinal 3'-oxygen, and the exposure of the 3' - phosphate of the ribonucleotides to the bulk water determines the availability of the bound water around the vicinal 2'-OH, which then can play various functional role through inter- or intramolecular interactions. (diva-portal.org)
  • Here, we review the roles of JA signaling in the tripartite interactions among plant, virus, and insect vectors, with a focus on the molecular and biochemical mechanisms that drive vector-borne plant viral diseases. (mdpi.com)
  • 3) It is a 25-amino acid neuropeptide (endorphins also fall into this category) that is pharmacologically distinct from the opioid/narcotics, local or general anesthetics, and is neither a salicylate nor an NSAID. (spineuniverse.com)
  • Non-acetylated salicylates should be used with extreme caution in patients with a history of or active GI disease including erosive gastritis, esophagitis, GI bleeding, peptic ulcer disease, or previous NSAID-induced bleeding. (pdr.net)
  • In my experience, most people with salicylate intolerance have no idea what could be affecting them. (fedup.com.au)
  • What is the role of salicylates in the etiology of Reye syndrome? (medscape.com)
  • [ 1 ] but recommendations by government health agencies that children not be treated with salicylates led to an immediate and dramatic decrease in the incidence of Reye syndrome. (medscape.com)
  • One study demonstrated that salicylates decrease beta-oxidation of the long-chain fatty acid palmitate by cultured fibroblasts from children who recovered from Reye syndrome as compared with control subjects. (medscape.com)
  • Pepto-Bismol should not be used by those aged under 16 due to a possible association between salicylates and Reye`s syndrome, a very rare but very serious disease. (medicines.org.uk)
  • The resident should be able to outline the role of hemodialysis in treating certain intoxications and drug overdoses, including methanol, ethylene glycol, salicylates, lithium etc. (ualberta.ca)
  • Salicylates, by inhibiting the synthesis of prostaglandins that occur in inflamed tissues, prevent the sensitization of the pain receptors to mechanical stimulation or to chemicals, such as bradykinin, that appear to mediate pain response. (intekom.com)
  • Renal function should be monitored periodically in patients receiving prolonged or high-dose salicylate therapy, as nephrotoxicity may occur. (pdr.net)
  • Hematocrit should be monitored periodically in patients receiving prolonged or high-dose salicylate therapy, as iron deficiency anemia may occur. (pdr.net)
  • Salicylates are chemicals that occur naturally in many plants - they're a kind of natural pesticide - to protect the plants against insects and diseases. (fedup.com.au)
  • In patients who develop gastric or duodenal ulcers during salicylate treatment, the drug should be discontinued due to an increased risk of bleeding and/or perforation. (pdr.net)
  • Salicylate caused greater auditory threshold shifts (near 15 dB) in GLAST KO mice than in WT mice across all tested frequencies, despite similarly reduced DPOAE. (frontiersin.org)
  • Salicylate-induced tinnitus is associated with changes related to central auditory neuroplasticity. (deepdyve.com)
  • Our previous studies revealed enhanced neural activity and ultrastructural synaptic changes in the central auditory system after long-term salicylate administration. (deepdyve.com)
  • In April 1977, the present study commenced with the development of an elimination diet, in order to investigate the role of food in recurrent idiopathic urticaria/angioedema. (nsw.gov.au)
  • Dr Swain carried out experiments between 1977 and 1986, quantifying the salicylate content of many foods and noting reactions in test subjects. (ndnr.com)
  • First isolated from willow ( Salix ), salicylates have been used as folk remedies since the 4th century B.C. (Weissman, 1991). (springer.com)
  • Over the last 15 years, I have talked and emailed to many thousands of people -approximately 95% female - about what I call failsafe eating (additive free, low in salicylates, amines and flavour enhancers). (fedup.com.au)
  • These three signals play important roles in induced resistance as well. (nih.gov)
  • This study unveils further SAR regulation mechanisms and highlights the role of glucosylation of MeSA and potentially other systemic signals in negatively modulating plant systemic defense. (plantphysiol.org)
  • We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. (frontiersin.org)
  • Using shorter ISI to obtain a greater dynamic range to assess tinnitus-like effects, we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32-kHz narrow band noise gap carrier in GLAST knockout (KO) mice when compared to their wild-type (WT) littermates. (frontiersin.org)
  • Unlike salicylates, NSAIDs and local anesthetics that exert analgesic effects (mostly through peripheral nerve/nociceptors) and unlike opioids and general anesthetics (act primarily at the level of the brain to obliterate pain and consciousness as well), the mechanism of therapeutic action of Ziconotide is through its capacity to bind to the N-type calcium channel receptor. (spineuniverse.com)
  • Growing evidence over recent years supports a potential role for low grade chronic inflammation in the pathogenesis of insulin resistance and type 2 diabetes. (uab.edu)
  • The present study is an extension of the studies led by Dr. Steven Shoelson that revealed the molecular pathogenesis of type 2 diabetes and the role of obesity in promoting diabetes and other metabolic conditions, including atherosclerosis. (medindia.net)
  • It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. (cdc.gov)
  • trace amounts of gentisate were detected by high-pressure liquid chromatography when strain WA46 was grown with salicylate. (asm.org)
  • Pepto-Bismol contains salicylates therefore care should be exercised if receiving drugs to thin the blood (anticoagulant therapy) or oral therapy for diabetes or treatment for gout. (medicines.org.uk)
  • The fact that grains and meat are very low in salicylates helped confirm my suspicions about her salicylate reactions, as she reported having no problems with most meats or gluten-based grains. (ndnr.com)
  • In some bacteria, salicylate is active as a siderophore ( 23 ) and also plays a role in gene regulation, such as the expression of antibiotic resistance ( 10 ). (asm.org)
  • The phenolate type siderophore, such as pyochelin in Pseudomonas aeruginosa, uses salicylate derived from chorismate as a precursor. (ku.edu)
  • Salicylate degradation has been studied in Pseudomonas spp. (asm.org)
  • The success of the diet may depend on the degree of a person's sensitivity to salicylates and food additives, and the amount of additives present in foods. (clarksnutrition.com)
  • What are some of the symptoms of salicylate sensitivity? (fedup.com.au)
  • It is quite apparent from the above discussions that Feingold hypothesis is still the central theoretical edifice when it comes to explaining the possible role of salicylates in several behavioural disorders. (talkingaboutthescience.com)
  • In some studies, the hypothesis that salicylates contribute to hyperactivity does not appear to hold up. (clarksnutrition.com)
  • Salicylates are also found in medications, fragrances, industrial chemicals, plastics and some pesticides, and can cause adverse effects when inhaled as well as eaten. (fedup.com.au)
  • The addition of a second dose of salicylate 4 h before an indicated endpoint suppressed C-Rel but not C/EBPbeta or interferon-gamma-regulated factor-1 binding at 8 and 24 h. (nih.gov)
  • A single dose of salicylate added with LPS/IFNgamma inhibited NOS-2 expression only at 4 h. (nih.gov)
  • Consequently, a systematic analysis of the total salicylate content of commonly eaten foods was undertaken using thin layer chromatography and high performance liquid chromatography, after which the elimination diet was modified and charts were constructed which could be used by salicylate-sensitive individuals to control the total daily dose of salicylate consumed. (nsw.gov.au)
  • Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies. (wines.com)
  • However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. (cdc.gov)
  • Salicylate treatment fully inhibited vascular inflammation, prevented microvascular insulin resistance and significantly improved muscle metabolic responses to insulin. (portlandpress.com)
  • We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. (portlandpress.com)
  • Recent studies have implicated fatty acid-dependent activation of the serine kinase IKKbeta, which plays a key role in tissue inflammation, in the pathogenesis of insulin resistance. (nih.gov)
  • Such evidence suggests that salicylate may compete with arachidonic acid for the active site of the COX enzyme. (aspetjournals.org)
  • We propose that salicylate inhibits C/EBPbeta binding at 4 h and C-Rel binding at 8 and 24 h by targeting related kinases. (nih.gov)
  • This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. (cmj.org)
  • Patients with renal impairment may be at increased risk of developing nephrotoxicity due to salicylate therapy. (pdr.net)
  • Salicylates should be used cautiously in patients with renal disease or systemic lupus erythematosus (SLE) due to the risk of decreased glomerular filtration rate in these patients. (pdr.net)
  • Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (pdr.net)
  • Patients should not receive salicylates if they consume 3 or more alcoholic beverages per day because of the potential increased risk for GI bleeding. (pdr.net)
  • The C.N.S., especially the hypothalamic nuclei, plays an indispensable role in regulating the peripheral mechanisms concerned with the production and loss of body heat. (intekom.com)
  • C-Rel binding and NOS-2 expression were abrogated by superoxide dismutase or apocynin at 4 h, suggesting a key role that superoxide plays in mediating C-Rel binding and NOS-2 transactivation only at 4 h. (nih.gov)
  • The obtained data suggest that plant resistance to the late blight is regulated via systemic induced resistance where JA plays an important role as an intermediate on conditions of active regulatory participation of SA. (deepdyve.com)
  • Nuclear factor-κB (NF-κB), a primary regulator of inflammatory responses, plays a critical role in a variety of physiological and pathologic processes. (ahajournals.org)
  • In the body, vitamin K plays a major role in blood clotting. (abovetopsecret.com)
  • It plays a critical role in the conversion of energy imbalance into the obesity state. (hindawi.com)
  • Several studies have shown that p38MAPK, an important signaling molecule, plays an important proinflammatory role in the development of ARDS at both the transcriptional and posttranscriptional levels. (scielo.br)
  • Base excision repair (BER) plays an important role in the maintenance of genome integrity and anticancer drug resistance. (cmj.org)
  • It was shown in recent years that the tumor microenvironment plays a critical role in tumor progression [ 2 ] . (jcancer.org)
  • Ginger also plays a great role in treating DVT. (top10homeremedies.com)
  • The mutant lacking tim still enters diapause when exposed to low temperatures, suggesting that tim plays a role not in diapause induction, but in photoperiodic mechanisms ( Riihimaa and Kimura, 1989 ). (biologists.org)
  • These results demonstrate that NO play plays a role in sound processing in the IC and further work is required to establish its functional significance. (bl.uk)
  • Programmed cell death (PCD) is a genetically encoded, active process that results in the death of individual cells, tissues, or whole organs, which plays an important role in the life cycles of plants and animals. (ebscohost.com)
  • 3,4 Indeed, in obese adipose tissue, the production of proinflammatory and antiinflammatory cytokines is dysregulated, which may play an important role in the development of obesity-related sequelae. (ahajournals.org)
  • The Feingold diet was developed on the premise that salicylates may trigger hyperactivity. (clarksnutrition.com)
  • Salicylate is widely produced by plants and some bacterial genera, e.g. (asm.org)
  • The salicylates are a widely distributed class of aromatic compounds. (springer.com)
  • The proinflammatory role of p38MAPK-activated protein kinase2 (MK2), the main downstream target of p38α/β, has been widely demonstrated in various reports. (scielo.br)
  • A possible interaction between salicylate and endogenous arginine vasopressin (AVP) was investigated. (springer.com)
  • Here we review recent advances and current knowledge on the role of classical primary defense hormones SA, JA and ET as well as their synergistic and antagonistic interaction in plant disease and immune responses. (eurekaselect.com)
  • Overall, this study delineates the roles of Lon protease, its substrate MarA and downstream targets of MarA, e.g. acrB and tolC , during NaSal-mediated growth reduction and antibiotic resistance. (microbiologyresearch.org)
  • Our results suggest a more comprehensive view of the gene networks governing SA function and provide a framework for further interrogation of the important roles of SA and possibly other signaling molecules in regulating plant disease resistance. (ebscohost.com)
  • the pain, essentially nocturnal, is spectacularly but transiently relieved by salicylates and is accompanied by often frank stiffness of the spine. (curehunter.com)
  • Salicylates are currently used as antimicrobials, food preservatives and analgesics. (springer.com)
  • Even with her avoidance of turmeric, she was supplementing daily with herbal extracts and "plant-based nutrients," which were actually another concentrated source of salicylates. (ndnr.com)
  • Cell extracts from Escherichia coli DH5α transformants harboring pUC19 that expressed each of the sdg ORFs showed that conversions of salicylate to salicylyl-coenzyme A (CoA) and salicylyl-CoA to gentisyl-CoA required SdgA and SdgC, respectively. (asm.org)
  • Blood glucose and concentrations of salicylate were measured once a week. (aspetjournals.org)
  • Use of salicylates and/or antibiotics can be effective in mild to moderate disease, while steroids are the accepted therapy for more severe active disease. (aafp.org)