Animal Use Alternatives: Alternatives to the use of animals in research, testing, and education. The alternatives may include reduction in the number of animals used, replacement of animals with a non-animal model or with animals of a species lower phylogenetically, or refinement of methods to minimize pain and distress of animals used.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Rodentia: A mammalian order which consists of 29 families and many genera.Mice, Inbred C57BLHuntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
"Systems and Diseases". Diseases of Small Domestic Rodents. 2003. pp. 127-31. doi:10.1002/9780470690840.ch14. ISBN 978-0-470- ... 2007). Animal Models in Toxicology (2nd ed.). CRC Press. p. 248. Grzimek, Bernhard, ed. (1972). Grzimek's Animal Life ... Richardson, V. G. C. (2003). Diseases of Small Domestic Rodents. Malden, MA: Blackwell Publishing. pp. 138-9. Flint, Vladimir ( ... Like all rodents, they must therefore gnaw regularly to keep their incisors from growing into the skin of the mouth and causing ...
Mouse Models for Human Diseases by Forward and Reverse Genetics". Animal models for the study of human disease (First edition. ... Committee on Rodents. "3. Criteria for Selecting Experimental Animals". Rodents. The National Academies Press. p. 23ff. CS1 ... However, if the specific mutation cannot be passed on, heterozygous animals should be used to breed with the original inbred ... National Research Council; Institute for Laboratory Animal Research; Commission on Life Sciences; ...
... inhibitors have also shown promise in treating autoimmune diseases in animal models. For example, studies in mice ... Inhibitors also show positive effects in rodent models of asthma. Labeling and inhibition of the proteasome is also of interest ... Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Creutzfeldt-Jakob disease, ... Studies in animal models suggest that ritonavir may have inhibitory effects on the growth of glioma cells. ...
Disease models in genetically modified animals are mainly in rodents, such as mice and rats. However, they cannot adequately ... Better animal models[edit]. Genetically modified animals represent an important instrument of modern biomedical research. In ... Research in animal models using mammals, such as even-toed ungulates (especially for animal health) and in very rare cases also ... Alternatives to animal experiments[edit]. "Animal experiments will remain necessary in biomedical research for the foreseeable ...
... via viral vectors generates levodopa-induced dyskinesia in animal models of Parkinson's disease. Dorsal striatal ΔFosB is ... overexpressed in rodents and primates with dyskinesias; moreover, postmordem studies of individuals with Parkinson's disease ... In order to avoid dyskinesia, patients with the young-onset form of the disease or young-onset Parkinson's disease (YOPD) are ... while many others have only shown promise in animal models. Attempts to moderate dyskinesia by the use of other treatments such ...
Knockout rat disease models for Parkinson's disease, Alzheimer's disease, hypertension, and diabetes, using zinc-finger ... Laboratory mouse Animal testing on rodents Morris water maze Rat genome database Vandenbergh, J. G. (1 January 2000). "Use of ... "Research Animal Models". Charles River. Retrieved 5 August 2012. D'Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, ... Like NOD mice, Biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features ...
However, introduction of exogenous α-SYN in a rodent animal model has been shown to induce functional deficits preceding cell ... There are three main types of synucleinopathy: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. ... Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation ...
Scientists studying this disease broadly accept Syrian hamsters as animal models for researching it. In this research, the ... are one of several rodents used in animal testing. Syrian hamsters are used to model human medical conditions including various ... cancers, metabolic diseases, non-cancer respiratory diseases, cardiovascular diseases, infectious diseases, and general health ... Because of this, hamsters are an excellent animal model for studying human metabolic disorder. Gallstones may be induced in ...
Soon after, MPTP was tested in animal models for its efficacy in inducing Parkinson's disease (with success). MPTP induced ... In other animals, such as rodents, the induction of Parkinson's by MPTP is incomplete or requires much higher and frequent ... Today, MPTP remains the most favored method to induce Parkinson's disease in animal models. Dopamine and serotonin Degradation ... The motor role of the pars compacta may involve fine motor control, as has been confirmed in animal models with lesions in that ...
... is an animal parasite. These filarial nematodes and their animal hosts are often used as models for ... Acanthocheilonema viteae, previously Dipetalonema viteae, is a rodent filarial worm that is often used as a model to study ... Filarial nematodes are the causative agents of filariases, tropical diseases that afflict about 160 million people worldwide. ...
Protection of neurons in the brain against dysfunction and degeneration in animal models of Alzheimer's disease, Parkinson's ... GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and ... Mattson's research on animal models and human subjects has resulted in the widespread adoption of intermittent fasting as an ... In related studies, several drugs that induce mild stress on mitochondria were found to be beneficial in animal models of ...
7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, ... including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, ... models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In ... translating animal models of PTSD to the clinic". Genes, Brain and Behavior. 11 (5): 503-512. doi:10.1111/j.1601-183X. ...
... induces levodopa-induced dyskinesias in animal models of Parkinson's disease. Dorsal striatal ΔFosB is overexpressed in rodents ... Volkow ND, Koob GF, McLellan AT (January 2016). "Neurobiologic Advances from the Brain Disease Model of Addiction". N. Engl. J ... and this induction is required for the therapeutic-like actions of these drugs in mouse models. Validation of these rodent ... Most of the animal research with HDAC inhibitors has been conducted with four drugs: butyrate salts (mainly sodium butyrate), ...
Animal models of Parkinson's disease and the acute physical stress model exhibited significant decrement of binding potential ... "Evaluation of serotonin 5-HT1Areceptors in rodent models using \18F]mefway PET". Synapse. 67 (9): 596-608. doi:10.1002/syn. ... Mefway (18F) undergoes in vivo defluorination in rodent brain and this phenomenon was effectively suppressed by cytochrome P450 ... in rodents and imaging by PET in a nonhuman primate". Journal of Nuclear Medicine. 47 (10): 1697-1706. PMID 17015907. Choi, JY ...
... and coronary artery disease. IP activation stimulates the dilation of arteries and veins in various animal models as well as in ... The injection of IP activators into the skin of rodents increases local capillary permeability and swelling; IP(-/-) mice fail ... While possessing many functions as defined in animal model studies, the major clinical relevancy of IP is as a powerful ... Studies using animals genetically engineered to lack FP and examining the actions of EP4 receptor agonists in animals as well ...
... subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease". ... agonist treatment is associated with protection against a range of experimental disease models such as Parkinson's Disease, ... "GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and ... 2013). "Glucagon-like peptides 1 and 2 in health and disease: A review". Peptides. 44: 75-86. doi:10.1016/j.peptides.2013.01. ...
... and rodent and other animal models in neuropsychiatric disorders. Functional studies in his laboratory have led to pathway ... discovery in autism, schizophrenia and Alzheimer disease, to more than a dozen animal models, and to a clinical trial showing ... Buxbaums research also extends into cell and animal models. His group has an extensive functional genomics laboratory using ... and they continue to examine molecular changes in this disorder using large brain cohorts and animal models. Buxbaum's research ...
This is an upgrade over the previous animal models of other small rodents and rabbits. Cotton rats combine the best traits of ... Some of the diseases tested on the cotton rat are respiratory syncytial virus, and pulmonary tuberculosis, and HIV type-1. In ... The tawny-bellied cotton rat is used as a model organism to develop and test human pathogen treatments. It is affected by many ... The tawny-bellied cotton rat (Sigmodon fulviventer) is a species of rodent in the family Cricetidae. It is found in Mexico and ...
Most studies of the biological effects of ginsenosides have been in cell culture or animal models and thus their relevance to ... Effects on the cardiovascular system, the central nervous system, the immune system have been reported, primarily in rodents. ... properties and could be useful in treating neurodegenerative disease such as Alzheimer's and Parkinson's diseases. Two broad ... in cell models as having an inhibitory effect on the cell growth of various cancer cells while studies in animal models have ...
It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, including ... Recently it has been found that CSF from MS patients can carry the disease to rodents, opening the door to an alternative model ... is an animal model of brain inflammation. It is an inflammatory demyelinating disease of the central nervous system (CNS). ... The model for primary progressive MS is the Theiler's virus model. This model presents features not available in others, like ...
6-hydroxydopamine toxicity in rodents may be a useful animal model for the syndrome, although this is not proven. However, the ... One of the first symptoms of the disease is the presence of sand-like crystals of uric acid in the diapers of the affected ... Another animal model for LNS has been proposed to arise from oxidative damage, caused by the hyperuricemia accompanying LNS. ... Likewise, 6-hydroxydopamine (the putative animal model for Lesch-Nyhan's neuropathy) apparently acts as a neurotoxin by ...
... an aqueous extract from the bark has been shown to reduce blood sugar levels in an experimental animal model of diabetes ... et Thonn.) Ficalho and Trema micrantha Blume extracts in rodents". Phytotherapy Research. 6 (3): 146. doi:10.1002/ptr. ... mellitus, and may be useful for treating this disease. Extracts from leaves of related species (Trema guineense and Trema ... The leaves are also browsed by game animals and can be used as spinach. This tree is a fast-growing species found in previously ...
... has been found to be effective in a variety of animal models relevant to drug abuse, addiction, and dependence, and ... In rodents, a low dose of nalfurafine (10-40 µg/kg) was found not to produce conditioned place preference or aversion, though a ... that is marketed in Japan for the treatment of uremic pruritus in individuals with chronic kidney disease undergoing ... The drug was originally developed as an analgesic in surgery, but while effective in animal models of nociception, it was ...
Currently active research directions include the search for new animal models of the disease and studies of the potential ... Models based on toxins are most commonly used in primates. Transgenic rodent models that replicate various aspects of PD have ... Harvey BK, Wang Y, Hoffer BJ (2008). "Transgenic rodent models of Parkinson's disease". Acta Neurochir. Suppl. Acta ... although animal models which show some features of the disease are used in research. The appearance of parkinsonism in a group ...
AV-101 showed efficacy in animal model of Huntington's disease and showed rapid-acting antidepressant effects similar to ... ketamine in the forced-swim test and two other behavioral models of depression in rodents. By 2013 AV-101 had successfully gone ... which provides a rationale for further testing in neurodegenerative diseases. 4-Chlorokynurenine is prodrug of 7- ...
Small animal imagingEdit. PET technology for small animal imaging: A miniature PE tomograph has been constructed that is small ... since more sophisticated models of the scanner Physics can be incorporated into the likelihood model than those used by ... Infectious diseasesEdit. Imaging infections with molecular imaging technologies can improve diagnosis and treatment follow-up. ... PET scanners designed specifically for imaging rodents, often referred to as microPET, as well as scanners for small primates, ...
... is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally ... it may be useful to investigate the striatal neuropathology of animal models. In a study of a transgenic rodent model of HD, ... and animal models [191,192] with HD. In animal models of HD, decrease of striatal glutamate receptors and glutamate release has ... DiFiglia, M. Excitotoxic injury of the neostriatum: A model for huntingtons disease. Trends Neurosci. 1990, 13, 286-289. [ ...
... derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntingtons disease: restoration by the ... It is used to model selective vulnerability of the striatum to metabolic stress in WT animals, and has been shown to be more ... Browne SE (2008) Mitochondria and Huntingtons disease pathogenesis: insight from genetic and chemical models. Ann N Y Acad Sci ... Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. Stephen J. ...
Our studies of renal phosphoinositide levels and metabolism in the pcy mouse with polycystic kidney disease (PKD) suggest that ... proteins in two rodent models of polycystic kidney disease Biochim Biophys Acta. 2002 May 21;1587(1):99-106. doi: 10.1016/s0925 ... Disease Models, Animal * Female * Isoenzymes / analysis * Isoenzymes / biosynthesis * Kidney / enzymology * Kidney / metabolism ... Disease-related increases in phosphatidylinositol 4-kinasebeta (PtdIns4Kbeta) and PLC(gamma1) levels were present in both ...
... tract of women are poorly understood at the molecular level as a result in part of the lack of relevant animal models. The ... present study describes a novel model of gynecological smooth muscle tumors in which these neoplasms arise in Eker rats as part ... Rodent model of reproductive tract leiomyomata. Clinical and pathological features Am J Pathol. 1995 Jun;146(6):1556-67. ... The high spontaneous incidence of smooth muscle tumors of uterus and cervix in this rodent model provides a unique opportunity ...
Usefulness of Animal Models - From Strains Selection to Mechanistic Studies , IntechOpen, Published on: 2015-04-22. Authors: ... Rodent models. 2.1.1. Mice model. Mice are the first model organism because of its easy reproduction and its low cost of ... Large animal models. Swine and dogs are an example of large animal models that have been investigated for allergy. They are ... 2. Animal models of food allergy, asthma and atopic dermatitis. In this chapter, only animal models that have been used to ...
2008) Animal models of Alzheimers disease and frontotemporal dementia. Nat Rev Neurosci 9:532-544. ... despite their clear effectiveness in animal models of stroke, might be due to the fact that the animal models involved young ... and genetic background of laboratory rodents is whether the rodent model in itself could have experimental drawbacks. Rodents ... Parkinsons disease, and many others).. We suggest that all investigators who employ rodent models in their research should ...
Graduate Research School Available Projects Using rodent models to identify treatments for peripheral artery disease ... Peripheral artery disease (PAD) is a common disorder in which blood supply to the extremities (commonly lower limb) is reduced ... assessing the therapeutic potential of re-purposed drugs and/or dietary interventions for PAD using a novel rodent model which ...
Animals. Attention / physiology. Brain / physiopathology*. Cytokines / physiology*. Disease Models, Animal*. Dopamine / ... Evidence from two epidemiologically informed developmental rodent models. ... Whether the convergent findings from these two models can be extended to other developmental animal models for this disease is ... Those of us that model schizophrenia developmental risk-factor epidemiology in animals in an attempt to understand how this may ...
Obesity induced in rodents occur mainly through HFD, HCD, FFD or genetic alterations like in Lep, Acox, KKy models. These ... and it is necessary to dertemine the mechanisms of these disorders in animal models of disease. Such models are usually the ... Thus, it is important to evaluate different animal models of obesity able to induce the profile of NAFLD and NASH disease in ... The aim of this chapter is to have a comparative analysis of animal models commongly used in the pathophysiology of obesity ...
... animal disease: Animals in research: the biomedical model: …more than 1,200,000 species of animals thus far identified, only a ... an identical or similar disease exists in at least one other animal species. Veterinary medicine plays an ever-increasing role ... few have been utilized in research, even though it is likely that, for every known human disease, ... In rodent: Importance to humans. …fur (see nutria and chinchilla), test animals for biomedical and genetic research (especially ...
"Systems and Diseases". Diseases of Small Domestic Rodents. 2003. pp. 127-31. doi:10.1002/9780470690840.ch14. ISBN 978-0-470- ... 2007). Animal Models in Toxicology (2nd ed.). CRC Press. p. 248. Grzimek, Bernhard, ed. (1972). Grzimeks Animal Life ... Richardson, V. G. C. (2003). Diseases of Small Domestic Rodents. Malden, MA: Blackwell Publishing. pp. 138-9. Flint, Vladimir ( ... Like all rodents, they must therefore gnaw regularly to keep their incisors from growing into the skin of the mouth and causing ...
... cardiovascular and renal disease, and cancer. These conditions are believed to be linked to a... ... Cobalt and aluminium in particular may serve as biomarkers of aging in animal models. Thus, elementary deposition in hair may ... Merrett DL, Kirkland SW, Metz GA (2010) Synergistic effects of age and stress in a rodent model of stroke. Behav Brain Res 214( ... Hair trace elementary profiles in aging rodents and primates: links to altered cell homeodynamics and disease. ...
In this study, the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal ... Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical ... The incidence of high-grade CNV lesions (grade IV) decreased from 20.5% in vehicle-treated animals to 1.7% (P , 0.05) at the 86 ... Eyedrops of aganirsen were applied daily in nonhuman primates after laser-induced choroidal neovascularization (CNV; model of ...
At present, transgenic pigs are increasingly being established as large animal models for selected human diseases. The first ... In this context rodent models are most widely used. ... Appropriate animal models for the evaluation of efficacy and ... facilitating the generation of tailored disease models. This article provides an overview of the current techniques for genetic ... modification of pigs and the transgenic pig models established for neurodegenerative diseases, cardiovascular diseases, cystic ...
Horizon provide custom animal model generation in addition to offering a comprehensive range of established animal models and ... Helping you obtain relevant models for your in vivo research. ... Rodent models Animal models designed to advance your disease ... Choose your next model Explore our extensive range of catalog and custom created animal models. ... Whether its creating your own animal model, or wanting help to achieve a specific model, were here to discuss your needs ...
Human Models of Schizophrenia and Psychosis Using LSD. *Early Animal Models. *Current Rodent Models of Schizophrenia or ... Neuropsychological Aspects of Methamphetamine Use Disorders and Human Immunodeficiency Virus Disease*Epidemiology of ... Animal Models Mimicking Illicit Drug-Induced Behaviors. *Effects of Raphe Lesions on Brain Serotonin Concentrations and the ... PCP-Induced Redox Dysregulation in an Animal Model of Schizophrenia. *PV Interneurons Are Susceptible to the Harmful Effects of ...
b) Rodent models.. c) Other animal models.. 9: The Role of the Microbiome in Skin Diseases. ... a) Rationale for use of animal models in microbiome research.. ... 12: The Role of the Mycome, Virome in Health and Disease. ... a) The mycome and virome in health and disease.. b) The interaction of the components of the microbiome including bacterial- ... b) The gut-brain axis-effects of the gut microbiome on behavior, mood, cognition, and role in nervous system diseases. ...
Disease models in genetically modified animals are mainly in rodents, such as mice and rats. However, they cannot adequately ... Better animal models[edit]. Genetically modified animals represent an important instrument of modern biomedical research. In ... Research in animal models using mammals, such as even-toed ungulates (especially for animal health) and in very rare cases also ... Alternatives to animal experiments[edit]. "Animal experiments will remain necessary in biomedical research for the foreseeable ...
"Rodent models of Alzheimers disease in drug discovery". Barrett JE and McGonigle P. In: Drug Discovery Approaches for the ... "Animal models of reward and loss". Barrett JE Conference report, Forum on Health and National Security, Center for the Study of ... "The pain of pain: The challenges of animal behavior models". Barrett JE European Journal of Pharmacology, 753, 183-190, 2015. ... "Circulating microRNA signatures in rodent models of pain". Qureshi RA, Tian Y, McDonald MK, Capasso KE, Douglas S, Gao R, ...
Animal models. PD is not known to occur naturally in any species other than humans, although animal models which show some ... "Transgenic rodent models of Parkinsons disease". Acta Neurochirurgica. Supplement. Acta Neurochirurgica Supplementum. 101: 89- ... Currently active research directions include the search for new animal models of the disease and studies of the potential ... Models based on toxins are most commonly used in primates. Transgenic rodent models that replicate various aspects of PD have ...
In Vivo-Intestinal Motility in Animal Model of Diseases. Studies on the prokinetic effects of exogenous ghrelin on diseases ... 1) Diabetic model: Qiu et al. published 3 papers in 2008 confirming their in vitro findings in two diabetic rodent models [40, ... In Vivo Gastric Motility in Animal Model of Diseases. Studies on the prokinetic effects of exogenous ghrelin on diseased ... in postoperative ileus or in healthy morphine-treated rodent model. However, when postoperative ileus animals were also given a ...
... choosing an animal model; the Institutional Animal Care and Use Committee; normative biology of rodent and non-rodent ... laboratory animals; diseases and other stressors and their effects on research; humane experimental endpoints and pain and its ... It is to the benefit of both science and animals to have a formal understanding of animal needs and animal use in the research ... and use to engender better science and enhanced animal welfare. Topics include controversies surrounding animal use in research ...
Basic research regarding animal models of human neurological disease requires that the animals exhibit hall mark ... these data are not available for most rodents including mice. NCV may be affected by animal age and size, body temperature, ... Animal models, particularly mice, are used extensively to investigate neurological diseases. ... Our laboratory is primarily concerned with animal models of diabetic neuropathy (DN) and uses NCV to confirm the presence of ...
The rats that dart between trashcans and crawl across subway tracks in New York may harbor some alarming diseases, according to ... Rats could be ideal animal models to help develop drugs and vaccines, especially since chimpanzees are no longer used for such ... Dirty Rats: NYC Rodents Carry Host of Diseases. By Megan Gannon 14 October 2014. ... And because these animals live close to people, there is ample opportunity for exchange." [10 Deadly Diseases That Hopped ...
  • and §Swedish Institute for Infectious Disease Control, Solna, Swe- spread of hantaviruses within a rodent host population. (cdc.gov)
  • Now scientists at the Division of Infectious Diseases of the Emory University School of Medicine and the Emory Vaccine Center have shown that Francisella novicida, a close relative of the bacterium that causes tularemia, and another bacterium that causes meningitis, need parts of the CRISPR system to stay infectious. (infectioncontroltoday.com)
  • CRISPR systems are bacterial defenses, but we've found that bacteria can use them offensively to hide from the host immune system and cause disease," says David Weiss, PhD, assistant professor of medicine (infectious diseases) at Emory University School of Medicine and Yerkes National Primate Research Center. (infectioncontroltoday.com)
  • Our Department offers three undergraduate degrees at Penn State: Immunology and Infectious Disease, Toxicology, and Veterinary and Biomedical Sciences. (psu.edu)
  • We also offer a graduate program in Pathobiology and our faculty are involved with inter-college graduate programs in Immunology and Infectious Disease and Molecular Toxicology. (psu.edu)
  • The 188th meeting of the National Advisory Allergy and Infectious Diseases Council (NAAIDC) convened at 10:30 a.m. on Monday, January 29, 2018 , in Conference Rooms E1/E2, Building 45, National Institutes of Health. (nih.gov)
  • Dr. Anthony S. Fauci, director, National Institute of Allergy and Infectious Diseases (NIAID) presided as chair. (nih.gov)
  • The National Advisory Allergy and Infectious Diseases Council convened in closed session to consider applications in allergy and immunology, microbiology and infectious diseases, and AIDS. (nih.gov)
  • Dr. Seema Nayak was chosen as the new director of the Office of Clinical Research Resources in the Division of Microbiology and Infectious Diseases. (nih.gov)
  • Dogs could be used as models for studying the immediate consequences of infectious disease, while pigs could be genetically engineered to mimic certain human conditions, such as deficiencies in the immune system. (innovations-report.com)
  • This observation together with the fact that human diabetes incidence is increased in industrialized countries lead to the "hygiene hypothesis" ( 16 ), which proposes that a lack of early childhood exposure to infectious agents increases susceptibility to autoimmune and allergic diseases later on in life. (diabetesjournals.org)
  • This bacterium causes leptospirosis, an infectious disease characterized by fever, vomiting, conjunctivitis and muscular pains. (sciencephoto.com)
  • Pathogenic serotypes cause leptospirosis in man, an infectious disease characterized by fever, vomiting, conjunctivitis and muscular pains. (sciencephoto.com)
  • Several paradigms are used to study the effects of genetics, brain injury, or certain compounds on learning and memory in rodents. (noldus.com)
  • In this study, the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal neovascularization. (nih.gov)
  • The diet-induced obesity model (DIO model) is an animal model used to study obesity using animals that have obesity caused by being fed high-fat and/or high-density diets. (wikipedia.org)
  • These animals can then be used to study in vivo obesity, obesity's comorbidities, and other related diseases. (wikipedia.org)
  • As such, the model was developed in order to create a controlled environment for the study of how obesity develops, as well as its effects. (wikipedia.org)
  • They plan to study the effects of the drug in animal models of neurodegenerative disease, and ultimately in clinical trials. (alzforum.org)
  • Hamsters represent an important small animal model to study a variety of fields including metabolism, carcinogenesis/tumorigenesis, inflammation and infection and disease. (hindawi.com)
  • We analyzed the statistical capabilities of the long-term rodent monitoring program begun in 1994 to detect spatial and temporal changes in rodent densities and determine if the low death rates at all study sites resulted in biased (underestimated) rodent population density estimates. (cdc.gov)
  • Current efforts concern study of a model of respiratory tree aspergillosis, to understand the predilection of lung transplant patients to invasive disease (in collaboration with the Div. of Pulmonary & Critical Care Med. (stanford.edu)
  • I study rodent and human models of bone and joint disease. (duke.edu)
  • Some of these changes allow scientists to study and develop new drugs to treat diseases on Earth. (nasa.gov)
  • Authors: Xiong Q, Liu J, Xu Y Abstract With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. (medworm.com)
  • The study, published in Spring 2016 by the National Academy of Sciences , stated "forecasting reservoirs of zoonotic disease is a pressing public health priority. (netnebraska.org)
  • The models have an 85 to 90 percent accuracy rate in distinguishing whether an animal is carrying zoonotic diseases, according to the study. (netnebraska.org)
  • Nonetheless, Khan says it's not a study to be dismissed and he welcomes having an additional tool that might predict where diseases might be a risk. (netnebraska.org)
  • Study of human immune responses to malaria parasite infection has been hampered by a lack of small animal models. (pnas.org)
  • The study used MRI scans and computer modeling to measure the activity of the glymphatic pathway among anesthetized rodents. (mercola.com)
  • In one animal study, inconsistent, intermittent sleep (similar to what might be experienced by shift workers) resulted in remarkably considerable, and irreversible, brain damage - the mice actually lost 25 percent of the neurons located in their locus coeruleus, a nucleus in the brainstem associated with arousal, wakefulness, and certain cognitive processes. (mercola.com)
  • Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study. (stanford.edu)
  • The results of a study published online this week by the Proceedings of the National Academy of Sciences indicate that the animals can survive numerous injections of cancer cells without succumbing to the disease. (scientificamerican.com)
  • For the first time, a new study demonstrates that certain rodents can be directly infected with CWD and therefore serve as animal models for further study of the disease. (medicalnewstoday.com)
  • Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. (iospress.nl)
  • Last but not least, this first section includes the review of newer invertebrate animal models, such as Drosophila to study neurodegeneration. (iospress.nl)
  • The results of this study suggest that MMP-2 plays a predominant role in retinal angiogenesis in both the mouse and rat models of oxygen-induced retinopathy. (arvojournals.org)
  • At Taconic Biosciences, our aim is to get your animal model to you ready for study use. (taconic.com)
  • Through this work we may have uncovered a biomarker for the disease itself," notes study leader Dr. Lesley Hoyles, from Imperial College London in the United Kingdom. (medicalnewstoday.com)
  • Currently, one of the greatest health concerns is the rise in obesity and its associated pathologies, such as metabolic syndrome, diabetes, cardiovascular disease, and cancer. (pnas.org)
  • Obesity is associated with a number of health problems that are often summarized together as metabolic syndrome and involve the development of insulin resistance, type 2 diabetes, cardiovascular disease and fatty liver disease [ 1 ]. (intechopen.com)
  • Davies S, Howard JM, Hunnisett A, Howard M (1997) Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients-implications for the prevention of cardiovascular disease and type II diabetes mellitus. (springer.com)
  • In reported incidents between 2016 and 2017, animals were found starved, dehydrated, drowned, and suffocated due to a lack of care by staff, or they died as a result of botched medical procedures. (onegreenplanet.org)
  • Those of us that model schizophrenia developmental risk-factor epidemiology in animals in an attempt to understand how this may translate to abnormal brain function have consistently shown that as adults these animals display behavioural, cognitive and pharmacological abnormalities consistent with aberrant DA signalling. (biomedsearch.com)
  • Human induced pluripotent stem cells (hIPSCs) present a unique opportunity to reduce animal use in studying the aetiology of neurodevelopmental disorders (NDD), such as schizophrenia (SZ) and Autism Spectrum Disorder (ASD). (nc3rs.org.uk)
  • What can mouse models of autism, schizophrenia and OCD tell us about the role of striatal circuitry in disease pathophysiology? (upenn.edu)
  • For this reason, we generated an adult zebrafish model, which is a simpler vertebrate model with higher throughput than rodents. (mdpi.com)
  • Based on these efforts of studying a gene-based inherited cardiomyopathy model, we discuss the strengths and bottlenecks of adult zebrafish as a new vertebrate model for assessing candidate cardiomyopathy genes. (mdpi.com)
  • Yang J, Shah S, Olson TM, Xu X. Modeling GATAD1 -Associated Dilated Cardiomyopathy in Adult Zebrafish. (mdpi.com)
  • Mesenchymal tumors of the lower reproductive tract of women are poorly understood at the molecular level as a result in part of the lack of relevant animal models. (nih.gov)
  • In dogs we are working on the molecular basis of Addison's disease, cleft palate, Intervertebral disc disease, myopia, vertebral spinal malformations and longevity. (ucdavis.edu)
  • In order to access the cellular and molecular processes that are responsible for habituation, we use the acoustic startle response and exploratory behaviour in an open field as behavioural models. (uwo.ca)
  • In this review, we summarize convergent evidence from two well-described developmental animal models, namely maternal immune activation and developmental vitamin D deficiency that begin to address this question. (biomedsearch.com)
  • As they investigated the mice further, Benoist and Mathis slowly began to figure out why these rodents' immune systems triggered arthritis. (thefreelibrary.com)
  • Moreover, as in rheumatoid arthritis, certain immune sentinels called T cells invaded the inflamed rodent joints. (thefreelibrary.com)
  • In this context, both epidemiology and animal models provide evidence for a link between maternal immune activation (MIA) during pregnancy and increased risk for NDD (including ASD and SZ), in the affected offspring. (nc3rs.org.uk)
  • The immune systems of the newly discovered animals are able to attack cancerous cells, but leave normal cells alone. (scientificamerican.com)
  • Many of the genes involved in disease susceptibility are major players in coordinating immune response. (diabetesjournals.org)
  • Therefore, we propose to develop a human cellular model of MIA using hIPSC, which can be applied to neural progenitor cells (NPCs) derived from keratinocytes obtained from healthy controls and individuals with highly penetrant disease-causing mutations for NDD such as major deletions in the chromsome 22q region, which confer risk for ASD and SZ. (nc3rs.org.uk)
  • In order to investigate AMD, cellular and animal models have been developed. (utwente.nl)
  • We therefore suggest that new guidelines with regards to laboratory animal husbandry should be developed and implemented that ensure that control animals are fed in portions rather than ad libitum and are provided environmental stimulation. (pnas.org)
  • The goal of this course is to provide a sufficient appreciation of laboratory animal biology, care, and use to engender better science and enhanced animal welfare. (umassmed.edu)
  • Laboratory animal studies demonstrate that these two monoterpenes inhibit the formation of chemically induced breast, colon, liver, skin and pancreatic tumors. (personalcaretruth.com)
  • 3. How do laboratory animal science professionals feel about their work? (amprogress.org)
  • Obesity is one of the major risk factors for the Nonalcoholic Fatty Liver Disease (NAFLD) development, as the leading cause of chronic liver disease. (intechopen.com)
  • The aim of this chapter is to have a comparative analysis of animal models commongly used in the pathophysiology of obesity that present NAFLD/NASH. (intechopen.com)
  • Driven by the worldwide epidemic of obesity, particularly in the Western world, the DIO model has been integral in understanding the relationship between high-fat/high-density diets and obesity, including the discovery of Akt and mTOR, signals in the body linked to obesity and insulin resistance. (wikipedia.org)
  • The DIO model was developed in response to growing concerns over the health effects of obesity, as well as the rapid growth of the obesity rate in countries around the world. (wikipedia.org)
  • While models are an important method of investigating the influences of obesity and drug testing, it is important to understand the limits of the model's overall ability to resemble the human obesogenic pathophysiology. (wikipedia.org)
  • Rodent models of obesity. (medworm.com)
  • Unlike mice, which die of cancer by the crateful, not a single one of her animals has ever developed a naturally occurring tumor. (slate.com)
  • They then discovered that plant monoterpenes interfered with animal cholesterol synthesis, thereby reducing cholesterol levels and reducing tumor formation in animals. (personalcaretruth.com)
  • For example, animals fed a diet containing 5 percent orange peel oil had a significantly reduced risk of developing mammary tumors when treated with the chemical tumor inducer DMBA. (personalcaretruth.com)
  • Similarly, animals fed a 5-percent limonene diet had less chance of mammary tumor growth. (personalcaretruth.com)
  • In the following table, we have attempted to consolidate those, predominantly immunologically related, reagents that we and others have used in the hamster model. (hindawi.com)
  • Peripheral artery disease (PAD) is a common disorder in which blood supply to the extremities (commonly lower limb) is reduced due to an accumulation of atherothrombosis within the arteries. (edu.au)
  • In the strain of mice most commonly used for DIO models, C57BL/6J, mice who started the diet at 10 weeks old showed lower increases in body weight and cholesterol than mice who started at 54 weeks, despite the same diet type and duration. (wikipedia.org)
  • Although commonly used, these models suffer from specific issues. (utwente.nl)
  • Whole rodent necropsy, tissue collection, gross examination with report. (irbbarcelona.org)
  • Examination of brain tissue from the two groups of mice revealed that canola oil-treated animals had greatly reduced levels of amyloid beta 1-40, a peptide which protects neurons from damage. (dailymail.co.uk)
  • Using organ-on-a-chip technology, a realistic model of the retinal vasculature, containing human endothelial tissue and retinal cells will be developed to investigate the effects of the treatment. (utwente.nl)
  • We will use this model to simulate the conditions of wet-AMD, measure the permeability of the cultured blood vessels, and evaluate the resulting damage and recovery to cultured retinal tissue both in the presence and absence of inflammatory and anti-inflammatory stimuli. (utwente.nl)
  • Alterations in the sequential establishment of gut microbiota observed in western countries could therefore be responsible for a T-helper balance deviation toward a Th2 profile, a major factor in the rise of allergic diseases. (intechopen.com)