Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Attitude to Death: Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Receptors, Death Domain: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mortality: All deaths reported in a given population.Autopsy: Postmortem examination of the body.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Infant, Newborn: An infant during the first month after birth.DNA Fragmentation: Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Cell Line, Tumor: A cell line derived from cultured tumor cells.Caspase Inhibitors: Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Caspase 8: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.Infant Mortality: Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.Death Domain Receptor Signaling Adaptor Proteins: Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.BH3 Interacting Domain Death Agonist Protein: A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.United Statesbcl-2-Associated X Protein: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Caspase 9: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.Fas Ligand Protein: A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Amino Acid Chloromethyl Ketones: Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.Homicide: The killing of one person by another.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Mice, Inbred C57BLSuicide: The act of killing oneself.Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Poly(ADP-ribose) Polymerases: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.bcl-X Protein: A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.bcl-Associated Death Protein: A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Programmed Cell Death 1 Receptor: An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Receptors, TNF-Related Apoptosis-Inducing Ligand: Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.TNF-Related Apoptosis-Inducing Ligand: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Vital Statistics: Used for general articles concerning statistics of births, deaths, marriages, etc.Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Hospitalization: The confinement of a patient in a hospital.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Asphyxia: A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.EnglandPopulation Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Terminal Care: Medical and nursing care of patients in the terminal stage of an illness.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Receptor-Interacting Protein Serine-Threonine Kinases: A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mortality, Premature: Deaths that occur before LIFE EXPECTANCY is reached within a given population.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Cytoprotection: The process by which chemical compounds provide protection to cells against harmful agents.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.bcl-2 Homologous Antagonist-Killer Protein: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.WalesCoronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Wounds, Gunshot: Disruption of structural continuity of the body as a result of the discharge of firearms.TNF Receptor-Associated Death Domain Protein: A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.Poisoning: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Recurrence: The return of a sign, symptom, or disease after a remission.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Inhibitor of Apoptosis Proteins: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.Caspase 1: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Caspase 2: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Forensic Pathology: The application of pathology to questions of law.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Stillbirth: The event that a FETUS is born dead or stillborn.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Lung Neoplasms: Tumors or cancer of the LUNG.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Animals, Newborn: Refers to animals in the period of time just after birth.Caspase 7: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Great BritainCell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Apoptotic Protease-Activating Factor 1: A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Breast Neoplasms: Tumors or cancer of the human BREAST.Staurosporine: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Acute Disease: Disease having a short and relatively severe course.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.JapanCalcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesDNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Receptors, Tumor Necrosis Factor, Type I: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Child Mortality: Number of deaths of children between one year of age to 12 years of age in a given population.SwedenChi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Microtubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.Grief: Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.Perinatal Mortality: Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.Proto-Oncogene Proteins c-akt: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
... fire risk; increasing rates of tree death; lack of rule enforcement, and lack of money. In 2010, the city hired a full-time ...
"Death threats? No. Risk? Yes". L.A. Times. Retrieved 2012-06-23. Bruno, Anothony. "The Bonanno Family". TruTV. Retrieved 2012- ... With Michael's tacit blessing, he ordered the deaths of Gilday, Keinszig and Lucchesi in one mass slaughter. However, Mary was ... Michael was devastated by his beloved daughter's death. Vincent begins his tenure as The Godfather. Boss (official and acting) ...
... the KSI risk curves using actual crash reconstruction data which led to the human tolerances for serious injury and death ... At the second level is real time risk reduction, which involves providing users at severe risk with a specific warning to ... poses several risks. The more serious risk is a collision with oncoming traffic. Since this is nearly a head-on collision, ... of Germany's traffic deaths. The autobahn fatality rate of 1.9 deaths per billion-travel-kilometres compared favorably with the ...
Calabria B, Degenhardt L, Hall W, Lynskey M (May 2006). "the risk of death? Systematic review of epidemiological evidence on ... elevated crash risk estimates. Likewise better controlled studies have found lower (or no) elevated crash risk estimates".[59] ... According to the Merck Index,[27] the LD50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for ... Researchers suggest that moldy cannabis should thus be discarded to avoid these serious risks.[citation needed] ...
HIV/AIDS - deaths[edit]. Up to 300 (2015 estimate)[1] Major infectious diseases[edit]. Degree of risk: high ... Deaths per year Natural change per year CBR1 CDR1 NC1 TFR1 IMR1 ... Children at risk of contracting HIV/AIDS in Afghanistan ... Note: WH5N1 avian influenza has been identified in this country; it poses a negligible risk as of 2009.[citation needed] ... 1 CBR = crude birth rate (per 1000); CDR = crude death rate (per 1000); NC = natural change (per 1000); TFR = total fertility ...
"The death of the US shopping mall". BBC News. November 4, 2014. Schwartz, Nelson D. (January 3, 2015). "The Economics (and ... Calculated Risk Blog. Pocock, Emil. "Shopping Center Studies at Eastern Connecticut State University". Eastern Connecticut ... "The Death of the American Mall and the Rebirth of Public Space". The International. Retrieved February 26, 2013. McBride, Bill ...
Calabria B, Degenhardt L, Hall W, Lynskey M (May 2006). "the risk of death? Systematic review of epidemiological evidence on ... elevated crash risk estimates. Likewise better controlled studies have found lower (or no) elevated crash risk estimates". The ... risk factors and risk perceptions". Drug and Alcohol Review. 23 (3): 319-44. doi:10.1080/09595230412331289482. PMID 15370012. ... According to the Merck Index, the LD50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male ...
Risk.ru (evlampei) (1992). "Winter Khan Tengri 1992 ". American Alpine Journal (Motomo Ohmiya & Valery Khrichtchatyi) (1993). " ... American Alpine Journal (Lindsay Griffin) (2005). "Asia, Kyrgyzstan, Tien Shan, Borkoldoy, Khan Tengri, Multiple Deaths". p. ... Khrichtchatyi's long-time friend Ilia Iodes and two British climbers also met their deaths. The body of one Englishman was ...
Risk factors[edit]. Occupational risk factors[edit]. Workers in certain fields are at risk of repetitive strains. Most ... Deaths. Unknown. A repetitive strain injury (RSI) is an injury to part of the musculoskeletal or nervous system which is caused ... Age and gender are important risk factors for RSIs. The risk of RSI increases with age.[14] Women are more likely affected than ... Mining Publication: Risk Profile of Cumulative Trauma Disorders of the Arm and Hand in the U.S. Mining Industry U.S. CDC-NIOSH ...
... fetal death also occurs in nearly all those cases. Abortion decreases the risk of death to the mother.[24] Some survivors ... Deaths. ~5,000 deaths per year[2]. Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic ... The virus is estimated to be responsible for about 5,000 deaths annually. The fever accounts for up to one-third of deaths in ... The risk of death once infected is about one percent and frequently occurs within two weeks of the onset of symptoms.[1] Among ...
Risk of death ~25%[1]. Necrotizing enterocolitis (NEC) is a medical condition where a portion of the bowel dies.[1] It ... Risk factors. Preterm birth, congenital heart disease, birth asphyxia, exchange transfusion, prolonged rupture of membranes[1] ... Rates of death were almost three times higher for the black populations than for the white populations.[16] ... The exact cause is unclear.[1] Risk factors include congenital heart disease, birth asphyxia, exchange transfusion, and ...
The risk of death following contracting the disease was about 30%, with higher rates among babies.[6][11] Often those who ... a b c d Giblin, James C. When Plague Strikes: The Black Death, Smallpox, AIDS. United States of America: HarperCollins ... severe platelet loss and poor immune response were often cited as causes of death.[28] In flat smallpox modes of death are ... death occurs suddenly about six days after the fever develops. Cause of death in hemorrhagic cases involved heart failure, ...
Risk of death ~ 25%[1]. Crimean-Congo hemorrhagic fever (CCHF) is a viral disease.[1] Symptoms of CCHF may include fever, ... The risk of death among those affected is between 10 and 40%.[1] It was first detected in the 1940s.[4] ... with one death.[clarification needed] As of August 2008, a total of 50 deaths were reported for the year thus far in various ... Between 2002-2008 the Ministry of Health of Turkey reported 3,128 CCHF cases, with a 5% death rate.[citation needed] In July ...
The acute form of the disease often presents with sudden severe abdominal pain and is associated with a high risk of death.[1] ... Among those affected even with treatment the risk of death is 70% to 90%.[3] In those with chronic disease bypass surgery is ... Risk factors. Atrial fibrillation, heart failure, chronic kidney failure, being prone to forming blood clots, previous ... Risk factors for acute mesenteric ischemia include atrial fibrillation, heart failure, chronic kidney failure, being prone to ...
Without treatment there is a 50%, 10 year risk of death, for the inherited versions. With treatment this decreases to less than ... This results in an increased risk of an irregular heartbeat which can result in fainting, drowning, or sudden death. These ... Seizures Sudden death. If there is sudden death, and doctors suspect long QT syndrome as the cause, they may recommend that the ... High risk (> 50%) - QTc > 500 ms, LQT1, LQT2, and LQT3 (males) Intermediate risk (30-50%) - QTc > 500 ms, LQT3 (females) or QTc ...
Complications for the baby include not getting enough oxygen which may result in death. It increases the risk of the mother ... This resulted in 23,000 maternal deaths down from 29,000 deaths in 1990 (about 8% of all deaths related to pregnancy). It is ... In 2013 it resulted in 19,000 maternal deaths down from 29,000 deaths in 1990. The word dystocia means difficult labour. Its ... Risk factors for a small pelvis include malnutrition and a lack of exposure to sunlight causing vitamin D deficiency. It is ...
"Children's Products and Risk - 00.11". Chicago Tribune (29 July 2008). "Safety bill a boy's sad legacy". chicagotribune.com ... In 1998, Ginzel and her husband, Boaz Keysar, founded Kids in Danger after the death of their son, Danny Keysar, who was ... Duncan, Ian (28 June 2012). "Chicago infant's death 14 years ago prompts stricter federal rules". Chicago Tribune. http:// ...
"Sabah quake: Death toll rises to 18; Malaysia to end search and rescue ops". The Straits Times. 10 June 2015. Retrieved 10 June ... "Incident Report of Earthquake 2015". Nepal Disaster Risk Reduction Portal. drrportal.gov.np. Retrieved 28 May 2015. "The Latest ... "China lowers death toll in Xinjiang quake to 3, says thousands of homes destroyed". South China Morning Post. July 4, 2015. ... This year was dominated by the earthquake in Nepal in April, with around 9,000 deaths. Another deadly event struck Afghanistan ...
The pattern indicates a sharp increase in risk of death for the widower, particularly but not exclusively, in the three months ... The death of a spouse can have a major impact on a person's mental health. Each individual may respond to their spouse's death ... Similarly, the Jewish men lived 5 years after the death of the wives while the Catholic men lived about 8 years after the death ... Catholic women lived 11 years after the death of their spouse while Jewish women lived 9.5 years after the deaths of their ...
The risk of death among those affected varies from 20 to 50%.[4] ... 20-50% risk of death[4]. Frequency. 1% of people admitted to ... Treatment of thrombosis with anticoagulants such as heparin is rarely used due to the risk of bleeding. ... has a significantly higher rate of death than DIC associated with trauma.[17] ...
This tradition, however, has changed following the death of Jaber Al Sabah [1977-2006]." Political Risk Yearbook, 1998. ... Political Risk Services. 1998. p. 48. ISBN 978-1-85271-371-3. : "The two branches of the Al-Sabah family, the Jabers and the ... The Belgian monarch does not automatically assume the throne at the death or abdication of his predecessor; he only becomes ... The Allegiance Commission will select a king and crown prince upon the death or incapacitation of either. This commission ...
Deaths Cause of death 27 January 1967 Apollo 1 Electrical fire in cabin, spread quickly by 16.7 psi (1.15 bar) pure oxygen ... Fatality risk[edit]. Further information: List of spaceflight-related accidents and incidents § Non-astronaut fatalities ... Use of a gas mixture carries risk of decompression sickness (commonly known as "the bends") when transitioning to or from the ... Without proper shielding, the crews of missions beyond low Earth orbit (LEO) might be at risk from high-energy protons emitted ...
Establish foresight of risk of death. Must show that a reasonable person in the circumstances and possessing the ... The dissent was of the opinion that the standard for manslaughter should be "objective forseeability [sic] of the risk of death ... It tells people that if they act in a dangerous manner even where death is not foreseeable, they may be held liable for any ... characteristics of the accused would foresee the act creating a risk of death. Lamer went into great detail on this last step. ...
Hatcher's testimony was characterized as an improper attempt by the prosecution to sway the jury toward a death sentence on the ... Threat assessment: A Risk Management Approach. Haworth Press. 2003. Retrieved 2007-10-17. Goleman, Daniel (April 21, 1993). " ... "Death in Waco". The New York Times. Retrieved 2007-10-17. "Portrait of a Poisoner". Time Magazine. October 18, 1982. Retrieved ... increasing the probability of violent deaths. In his analysis, the first stage of violence occurs when the cult leader tells ...
... grave risk of death to others; procurement of murder by payment or promise of payment; commission of murder for pecuniary gain ... Arizona's death row for males is located at the Arizona State Prison Complex - Florence in Florence. Female death row prisoners ... When the prosecution seeks the death penalty, the sentence is decided by the jury and must be unanimous. In case of a hung jury ... List of individuals executed in Arizona List of death row inmates in Arizona Crime in Arizona Law of Arizona "§ 13-752 ...
Johnny Risk. Episode: Johnny Risk Studio One. Rafael Martinez. Episoden: Man Under Glass ... Report on death of Mark Landon Eksterne henvisninger[redigér , redigér wikikode]. *. Wikimedia Commons har flere filer ...
... research shows parents and caregivers can help reduce the risk of SIDS and other sleep-related infant deaths by doing the ... Find out more about breastfeeding your baby to reduce the risk of SIDS pdf icon[480 KB]external icon. ... can learn more about these recommendations at Ways to Reduce the Risk of SIDS and Other Sleep-Related Causes of Deathexternal ... messages and educational materialsexternal icon about ways to reduce the risk of SIDS and other sleep-related infant deaths. ...
17 The death certificate database includes all deaths in Ontario. Causes of death were determined from death certificates, ... Risk of death among homeless women: a cohort study and review of the literature. Angela M. Cheung and Stephen W. Hwang ... In studies from a total of 7 cities, the risk of death among homeless women was greater than that among women in the general ... Risk factors for death in homeless adults in Boston. Arch Intern Med 1998;158 (13):1454-60. ...
... may actually raise the risk of death, a review of 68 studies on nearly a quarter-million people said on Tuesday. ... While the review did not pinpoint any biochemical mechanism that may be behind the increased death risk, it may be that "by ... It said the increased death risk is about 5 percent higher than those not given supplements and that figure is probably ... "Even more, beta carotene, vitamin A and vitamin E seem to increase the risk of death." ...
Healthy pregnant women are at high risk of hospitalization and death from H1N1 swine flu. Tamiflu or Relenza is recommended for ... Pregnancy Raises Swine Flu Death Risk. Healthy Pregnant Women at Risk of H1N1 Swine Flu Death, Hospitalization ... "But it does seem pregnant women are at increased risk of severe illness and death. So the proportion of deaths among pregnant ... That risk is based on her pregnancy and not on other risk factors. "Pregnant women are at risk just by virtue of being pregnant ...
Men diagnosed with prostate cancer may be able to reduce their risk of death not just from prostate cancer but from any cause ... Exercise Cuts Prostate Cancer Death Risk. 3 Hours of Vigorous Activity a Week Associated With a 61% Lower Risk of Prostate ... 6, 2011 -- Men diagnosed with prostate cancer may be able to reduce their risk of death not just from prostate cancer but from ... Men who reported vigorous activity for at least three hours per week had a 61% lower risk of a prostate cancer-specific death, ...
People who use opium have a considerably higher risk of dying from any cause, especially from cancer, respiratory conditions, ... During the study period 2,145 deaths were reported.. The authors found that opium usage was associated with an 86% greater risk ... An international team of researchers set out to find out whether opium usage might be linked to subsequently higher death risk. ... The researchers say that this is the first study to compare death risk among opium users versus non-users. ...
After Jason risks his life in a rash attempt to save two scuba divers trapped on a reef, Sean threatens to throw Jason off the ... team if he doesnt change the way he thinks about the risks and lives of people in need of a rescue in which Jason is confined ... Risk to Death TV-PG , 1h , Action, Drama , Episode aired 1 November 1999 ... After Jason risks his life in a rash attempt to save two scuba divers trapped on a reef, Sean threatens to throw Jason off the ...
High blood sugar levels increased the chances of death among patients in intensive care units, according to a study of more ... The study found the lowest death rates among emergency room patients with low levels of blood glucose or at the lower end of ... The death rates were significantly higher for patients with glucose levels in the high or high-normal range. ... High blood sugar levels increased the chances of death among patients in intensive care units, according to a study of more ...
After the death Saturday of a USC freshman from what may be bacterial meningitis, university officials are urging anyone who ... Infection-Risk Alert Follows Student Death. Anyone who had recent close contact with the USC freshman from Dana Point should be ... After the death Saturday of a USC freshman from what may be bacterial meningitis, university officials are urging anyone who ... No one else at the hospital is considered at risk, Weismuller said. ...
Tree nuts may lower risk of colon cancer recurrence, death Eating at least 2 ounces of tree nuts every week could reduce the ... When programmed cell death goes wrong. Cancer cells are masters at evading our immune system and avoiding death. When a cancer ... But cell death pathways do not happen in isolation, and activating one type of cell death does not guarantee that a cell does ... Cancer: Novel cell death technique may be better than chemo A study suggests that a new cell death method - called caspase- ...
... a well-established risk factor for developing breast cancer - was not associated with a higher death risk compared with ... appears to worsen the inflammatory process that leads to the death of cells in the pancreas that produce insulin. Study ... BREAST CANCERDensity doesnt raise death riskWomen with dense breast tissue do not have an increased risk of death from breast ... Density doesnt raise death risk. Women with dense breast tissue do not have an increased risk of death from breast cancer, ...
... resulting in car driver deaths. Researchers computed the relative risks of car driver deaths in crashes with complying versus ... For unbelted car drivers, the fatality risk wasnt reduced if the light trucks complied with the commitments. That is, death ... In crashes with SUVs, the car driver death risk was 18-21 percent lower if the SUV was in compliance. ... Estimated fatality risk reductions for car drivers. Car driver belt use. Risk reduction. ...
The authors also said the increased risk of death attributable to lack of insurance suggests that alternative measures of ... Among the other factors that increased the risk of death were clinically-verified poor health (222 percent), smoking (102 ... In fact, the risk factor is 2.5 times higher than a 2002 estimate from the Institute of Medicine (IOM), which that suggested ... According to the report, published today in the Journal of Public Health, lack of health insurance was a factor in the death of ...
... but others caution that the overall risks and benefits of pacifier use remain unclear ... As well as the reduced risk of death, the study showed that using a pacifier cancelled out the risks posed by other known risk ... Babies who sleep with a pacifier (dummy) have a reduced risk of cot death, according to a new population-based study. Using a ... that the study suggests no benefit from using a pacifier in some of the babies most at risk of cot death, such as those with ...
They know the risks are extreme, yet still they do it. ... The death has thrown a spotlight on "pumping," a thriving ...
... Study finds large numbers of prescriptions could be to blame. by Gary Strauss, ... "Previous studies have shown that about 25 percent of U.S. overdose deaths had no drug information on the death certificate, so ... The findings are based on National Center for Health Statistics data from 1999 to 2014, during which the U.S. death rate from ... Mortality rates from these overdoses could be even higher than the statistics indicate because such drug-related deaths tend to ...
Four easy-to-adopt lifestyle behaviors are associated with a significantly lower risk of death, according to a new MESA ... Lower Risk of Death Clinically, a healthier lifestyle also translated into a significant reduction in all-cause mortality and a ... Individuals who adopted all four healthy behaviors had an approximate 80% lower risk of death than those with no healthy ... Cite this: Four Healthy Lifestyle Behaviors Lower Risk of Death, Slow CAC Progression - Medscape - Jun 04, 2013. ...
... that adults with DM1 are at high risk for arrhythmias and death and they identified independent risk factors for sudden death ... Table 2. Risk for Sudden Death in the Invasive Compared with Noninvasive Group ... Table 1. Risk for Death in the Invasive Compared with Noninvasive Group ... The risk for sudden death was about 75% lower in the invasive strategy group, regardless of the analytical method applied, the ...
... according to the largest analysis ever to examine the impact of gender on heart failure deaths. ... higher death risk than women, and male gender was an independent risk factor for death. ... home/heart center/ heart a-z list/ heart failure death risk lower for women article ... The researchers concluded that more study is needed to understand why the risk of death from heart failure is lower among women ...
A fatal adverse event (FAE) is defined as a death caused in all likelihood by a drug and is a major cause of fatality in the ... The authors write that given the absolute risk of treatment-related mortality appears low, the use of bevacizumab should be ... Compared with chemotherapy alone, the addition of bevacizumab was associated with a 1.5 times increased risk of FAEs. This ... Bevacizumab was associated with a 3.5 times increased risk of FAEs in patients receiving taxanes or platinum agents (3.3 ...
... themselves causing asthma attacks or even death, experts have warned. ... Commonly used asthma drugs could be putting peoples lives at risk, ... Commonly used asthma drugs could be putting peoples lives at risk, themselves causing asthma attacks or even death, experts ... with recent clinical trials suggesting an increase in the number of deaths among asthmatics using them. ...
Pfizer Incs antibacterial drug Tygacil increases the risk of death whether used as authorized by the U.S. Food and Drug ... In September 2010, the FDA issued a reminder to physicians that Tygacil carried a higher risk of death than other drugs used to ... Reuters) - Pfizer Incs antibacterial drug Tygacil increases the risk of death whether used as authorized by the U.S. Food and ... The agency said the increased risk of death was mostly seen in patients with hospital-acquired pneumonia though it was also ...
Predicting risk for death from MRSA bacteremia.. Pastagia M1, Kleinman LC, Lacerda de la Cruz EG, Jenkins SG. ... We used regression risk analysis to quantify the association between clinical correlates and death. We found that older age, ... To determine predictors of risk for death, we conducted a retrospective cohort study. We examined 699 episodes of MRSA ... consultation with an infectious disease specialist was associated with lower risk for death; and MRSA strain types were not ...
... may also reduce the risk of dying from cancer, according to new research. ... long recommended for people at high risk of heart attack, ... Daily Aspirin and Cancer Death Risk: Perspective. The new study ... home/cancer center/ cancer a-z list/ daily aspirin may reduce risk of cancer death article ... A previous study by others found daily aspirin reduced cancer death risk by 37%. "In our analysis, daily aspirin use was ...
Predicting risk of death from cardiovascular disease. BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7319.999/a (Published ... EDITOR-I would like to predict the risk score for all patients in my practice aged 35 years or older as so clearly described in ... Is there any possibility of extrapolating the risk scores to an older age? ... the article by Pocock et al.1 My enthusiasm invariably turns to disappointment when using risk scores because of the following ...
  • 15 A study of people using homeless shelters in New York found age-adjusted death rates 2 to 3 times higher than those in the city's general population. (cmaj.ca)
  • While the review did not pinpoint any biochemical mechanism that may be behind the increased death risk, it may be that "by eliminating free radicals from our organism, we interfere with some essential defensive mechanisms," the study concluded. (reuters.com)
  • Balz Frei, director of the Linus Pauling Institute at Oregon State University, said the study and the data studied are both flawed because more than two-thirds of the previous research that was examined involved people with heart disease, cancer or other risks who were being treated to see if the supplements worked. (reuters.com)
  • The Natural Products Association, a supplement trade group, said the study "stands in stark contrast to large actual clinical studies that have not demonstrated any increased risks. (reuters.com)
  • Our results suggest that men can reduce their risk of prostate cancer progression after a diagnosis of prostate cancer by adding physical activity to their daily routine," study author Stacey Kenfield of Harvard says in a news release. (webmd.com)
  • The researchers say that this is the first study to compare death risk among opium users versus non-users. (medicalnewstoday.com)
  • During the study period 2,145 deaths were reported. (medicalnewstoday.com)
  • High blood sugar levels increased the chances of death among patients in intensive care units, according to a study of more than 1,800 patients at Stamford Hospital. (courant.com)
  • The study found the lowest death rates among emergency room patients with low levels of blood glucose or at the lower end of normal range. (courant.com)
  • While more study is needed to confirm the links, the studies suggest that another benefit of maintaining a healthful weight may be a reduction in prostate cancer risk, according to authors of the reports, published Monday in the online edition of the Journal of Clinical Oncology. (courant.com)
  • Women with dense breast tissue do not have an increased risk of death from breast cancer, according to a study by the National Cancer Institute . (sfgate.com)
  • The study, which appeared Monday in the Journal of the National Cancer Institute, looked at the cases of 9,000 women with breast cancer and determined that high breast density - a well-established risk factor for developing breast cancer - was not associated with a higher death risk compared with patients with lower density breasts. (sfgate.com)
  • Girls with attention deficit hyperactivity disorder (ADHD) are at high risk of hurting and even trying to kill themselves, a new study from UC Berkeley cautions. (sfgate.com)
  • Babies who sleep with a pacifier (dummy) have a reduced risk of cot death, according to a new population-based study. (newscientist.com)
  • They study found a 90% reduced risk of SIDS in babies who used a pacifier, compared to those who did not. (newscientist.com)
  • However, the UK's Foundation for the Study of Infant Deaths (FIDS) cautions that while the new study appears convincing, the overall picture remains very complicated. (newscientist.com)
  • As well as the reduced risk of death, the study showed that using a pacifier cancelled out the risks posed by other known risk factors, such as very soft bedding. (newscientist.com)
  • A study in 2000 suggested that the risk for SIDS only increases for babies who are used to sleeping with a pacifier and then stop. (newscientist.com)
  • The FIDS spokesperson notes another complication - that the study suggests no benefit from using a pacifier in some of the babies most at risk of cot death, such as those with low birthweight. (newscientist.com)
  • Previous studies have shown that about 25 percent of U.S. overdose deaths had no drug information on the death certificate, so it is likely that national statistics underestimate the number of opioid-related deaths,'' said Columbia University professor Xiwen Huang, one of the three authors of the study. (aarp.org)
  • The researchers found that when boomers aged from their 40s to 60s, they experienced consistently higher death rates from opioid overdoses than other generations at the same age, according to Guohua Li, senior author of the study. (aarp.org)
  • March 27, 2012 - In a retrospective study of adults with myotonic dystrophy type 1 (DM1) and major infranodal conduction delays, an invasive strategy based on electrophysiologic study and prophylactic permanent pacing was associated with a lower incidence of sudden death and a higher survival rate at 9 years, compared with a strategy based solely on noninvasive follow-up. (medscape.com)
  • The researchers concluded that more study is needed to understand why the risk of death from heart failure is lower among women than men. (medicinenet.com)
  • To determine predictors of risk for death, we conducted a retrospective cohort study. (nih.gov)
  • The study, published online in the journal Circulation, found people who consumed fast-food even once a week increase their risk of dying from coronary heart disease by 20 percent, in comparison to people who avoid fast-food. (upi.com)
  • An analysis of nearly 25 years of data for about 10,000 civil servants in London finds an association between socioeconomic position and risk of death, with much of this relation accounted for by health behaviors such as smoking, alcohol consumption, diet and physical activity, according to a study in the March 24/31 issue of JAMA. (redorbit.com)
  • More than half of the early deaths analyzed in the study were blamed on natural causes, such as acute and chronic illnesses like heart disease. (livescience.com)
  • I think it's an important study that's drawing attention to the general health risk that's associated with a range of psychiatric disorders," said Dr. Mark Olfson, a professor of psychiatry at Columbia University, who wasn't involved in the study. (livescience.com)
  • Indeed, about 67 percent of the deaths analyzed in the study were blamed on natural causes, while about 17 percent were due to unnatural causes, such as suicide and accidental injury. (livescience.com)
  • The rest of the deaths in the study had unknown causes. (livescience.com)
  • NEW YORK, Sept. 15 (UPI) -- Chemical particles in the air increase the overall risk of death, as well as increasing the risk of death from heart disease and respiratory disease, researchers found in a large study. (upi.com)
  • New York, March 12 (IANS) Even a single episode of severe hypoglycemic condition -- having low blood glucose levels -- may be associated with nearly double the risk of cardiovascular disease or death in older adults with Type 2 diabetes, a study has found. (yahoo.com)
  • Dealing with worries and demands from close family was also linked to a higher mortality risk, the study said. (bbc.com)
  • In this study, the researchers said physiological reactions to stress, such as high blood pressure and an increased risk of cardiovascular disease, were most likely to explain the increased mortality risk. (bbc.com)
  • The study said: "Men respond to stressors with increased levels of cortisol, which may increase their risk of adverse health outcomes. (bbc.com)
  • The study found that frequent worries or demands generated by partners and children were linked to a 50%-100% increased risk of death from all causes. (bbc.com)
  • Those who were unemployed were at significantly greater risk of death from any cause than those who had a job, the study said. (bbc.com)
  • A new study links social isolation with a higher risk of death. (psychcentral.com)
  • There also was an increased risk of death from cancer in white men and women, the study discovered. (psychcentral.com)
  • The findings "indicate that a composite measure of social isolation is a robust predictor of mortality risk among men, women, blacks, and whites," the researchers say in the study, which was published in the American Journal of Epidemiology . (psychcentral.com)
  • Fiber reduces the risk of dying from colorectal cancer, according to a new study published in JAMA Oncology . (pcrm.org)
  • As part of Harvard's Nurses' Health Study and Health Professionals Follow-Up Study, researchers looked at 1,575 participants with colorectal cancer and analyzed their diets and risk for mortality. (pcrm.org)
  • First, they calculated study participants' duration of marijuana use, then they combined the information with mortality data from the 2011 National Center for Health Statistics and estimated the effects of marijuana use on deaths from hypertension, heart disease, and cerebrovascular disease (stroke, for example). (healthcentral.com)
  • During the 15-year study, 335 deaths occurred, the majority of which were from cancer. (mercola.com)
  • During the 15-year study, 335 deaths occurred. (mercola.com)
  • The case study detailed here underscores both the scientific inefficiency and the real risks to patients of the current failure to report data promptly,' they said. (cnn.com)
  • Even when parents take steps to remove unsafe items from their bed, bed-sharing remains a risk factor for SIDS and other sleep-related causes of infant deaths, a new study suggests. (usatoday.com)
  • In two-thirds of 8,207 cases reviewed in the study, infants were bed-sharing with an adult at the time of death, but a larger proportion of younger infants (ages 0 to 3 months) were bed-sharing compared with older infants, 74% vs. 59%, finds the research published online today in Pediatrics . (usatoday.com)
  • So many of the deaths that we saw in this study were in the context of bed sharing, yet, at least according to the (state review teams that provided the data) there were no other objects in the bed that would have made an additional risk," he says. (usatoday.com)
  • The risk of pregnant women dying after IVF treatment is more than three times higher than women who conceive naturally, according to a recent study conducted in the Netherlands. (marieclaire.co.uk)
  • A newer cholesterol drug, used with older statin medicines, modestly lowered heart risks and deaths in a big study of heart attack survivors that might persuade insurers to cover the pricey treatment more often. (foxbusiness.com)
  • The new study tested the rival drug, Praluent, for a longer time and in patients at higher risk - nearly 19,000 people who in the previous year had a heart attack or chest pain serious enough to put them in the hospital. (foxbusiness.com)
  • Breast-feeding is already known to provide a slew of benefits to mother and baby, and now one more positive can be added to the list: it reduces the risk of sudden infant death syndrome, a new study says. (livescience.com)
  • A regular serving of fried chicken or fish is associated with a higher risk of death from any cause except cancer, according to a new study done in postmenopausal women in the United States. (cnn.com)
  • Women who enjoyed fried chicken once or more per day had a 13% higher risk of death from any cause compared with women who did not eat any fried food, according to the study , published Wednesday in the medical journal BMJ. (cnn.com)
  • A 2017 study found that people who eat fried potatoes two or more times a week double their risk of an early death compared with those who avoid them. (cnn.com)
  • We identified a total of 135 deaths and cardiac arrests in U.S. triathlons from the inception of the sport in 1985 through 2016," said study lead author Dr. Kevin Harris. (hon.ch)
  • For the study, the team examined 30 years of data collected by the U.S. National Registry of Sudden Death in Athletes. (hon.ch)
  • He cautioned that the findings may actually underestimate the true risk, given that "some victims might not have been reported or identified during the study. (hon.ch)
  • Our study shows that a population almost twice the size of Port Douglas is being wiped out in Australia each year - with smoking causing more than 6,400 cardiovascular deaths, including from heart attack and stroke. (news-medical.net)
  • 2019) Tobacco smoking and risk of 36 cardiovascular disease subtypes: fatal and non-fatal outcomes in a large prospective Australian study. (news-medical.net)
  • Jardiance sharply reduced chances of dying in diabetic patients at high risk of heart complications, a study shows, making the Type 2 diabetes medication the first shown to lengthen diabetics' lives. (timesunion.com)
  • The study found Jardiance reduced deaths from heart complications by 38 percent, deaths from any cause by 32 percent and hospitalizations due to chronic heart failure by 35 percent. (timesunion.com)
  • Last month, the drugmakers announced their study showed cardiovascular deaths were lower in participants taking Jardiance than those given a dummy pill, in addition to standard heart and diabetes drugs. (timesunion.com)
  • Having three or more traits of the so-called metabolic syndrome significantly increases the risk of dying from coronary heart disease, cardiovascular disease or any other cause, according to a new study. (scienceblog.com)
  • The study emphasizes the importance of close risk-factor monitoring and management, particularly blood pressure and dyslipidemia (abnormal levels of blood fats), which are common in those with the metabolic syndrome," Wong said. (scienceblog.com)
  • What we think is going on is that the mist inhaler is delivering a higher concentration of tiotropium than it should be and that may be increasing the risk of death,' Dr. Sonal Singh of Johns Hopkins University School of Medicine, who led the study, said in a statement. (foxnews.com)
  • The inhaler is approved for use in Britain and Europe, but failed to win a nod from the U.S. Food and Drug Administration , which noted an excess number of deaths in a study of 17,000 patients. (foxnews.com)
  • We estimate that there will be one additional death for every 124 patients treated for a year with tiotropium Respimat,' Dr. Yoon Loke of Norwich Medical School at the University of East Anglia, who worked on the study, said in a statement. (foxnews.com)
  • Washington, DC--People who have metabolic syndrome are more likely to die from cardiovascular disease than people who do not have the condition, and having diabetes or high blood pressure worsens the risk, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism . (eurekalert.org)
  • The analysis tells us diabetes and high blood pressure are significant factors that elevate the risk of death from cardiovascular disease among people with metabolic syndrome," said another author of the study, Prof..Eun-Jung Rhee, MD, PhD, of Kangbuk Samsung Hospital at Sungkyunkwan University School of Medicine. (eurekalert.org)
  • The current study emphasizes that the mortality risk becomes much more pronounced with longer term prescriptions. (eurekalert.org)
  • The Daily Mail gave a better overview of the study, although the claim that "three slices of wholemeal bread a day slash the risk of dying of heart disease by 25%" is slightly exaggerated. (www.nhs.uk)
  • The German Study of Sudden Infant Death is a case-control study of 333 infants who died of sudden infant death syndrome and 998 age-matched controls. (aappublications.org)
  • This study shows that breastfeeding reduced the risk of sudden infant death syndrome by ∼50% at all ages throughout infancy. (aappublications.org)
  • The aim of the German Study of Sudden Infant Death (GeSID) was to identify risk factors for SIDS in a population where only few infants sleep prone. (aappublications.org)
  • Men also had higher mortality rates than women six months after hip fracture - and the men's scores on cognitive tests were significantly associated with their risk of death: those who did poorly on the tests were more likely to die during the study. (reuters.com)
  • A new study from the University of Iowa found strong associations between those who skipped breakfast and death from cardiovascular disease. (msn.com)
  • Now though, an eight-year study has found those who regularly eat french fries have double the chance of death than those who don't. (news.com.au)
  • As this study was observational it was not possible to conclude that these factors were the reason that risk was reduced. (biomedcentral.com)
  • Due to the observational nature of this study, however, it is not possible to conclude that these various reproductive factors are the cause of the reduction in risk that has been seen. (biomedcentral.com)
  • CN) - Adding fuel to the adage "sitting is the new smoking," a new study finds that sitting for extended periods of time is a significant risk factor for all causes of death. (courthousenews.com)
  • This study examined the relationship of in-hospital death and 13 conditions likely to have been present prior to the patient's admission to the hospital, defined using secondary discharge diagnosis codes. (nih.gov)
  • The study also found a higher risk of depression and irritable bowel syndrome (IBS) in these women. (psychcentral.com)
  • Study participants were followed for 10 years for the development of heart disease and for death from any cause. (psychcentral.com)
  • While taking ATVs and other such vehicles on busy streets is certainly dangerous, a new study suggests that the age of riders may be an even bigger risk factor. (consumeraffairs.com)
  • A study published in October 2016 in JAMA Internal Medicine shed some light on these questions as they related to long-term risk of death from heart disease and cancer. (everydayhealth.com)
  • And for every 3 percent substitution of plant protein in place of animal protein, cancer-related death in study participants dropped by 17 percent. (everydayhealth.com)
  • This is the first study to determine diabetes as a risk factor for mortality after lung transplantation. (endocrineweb.com)
  • Kathryn L. Hackman, MD of Monash University, and a Visiting Endocrinologist at The Alfred Hospital in Melbourne, Australia led the study revealing diabetics have a 5.6 fold increased risk of death after lung transplant. (endocrineweb.com)
  • People who eat more red or processed meat have a higher risk of death from all causes including cancer, while a higher consumption of white meat reduces such risks, a study found. (health24.com)
  • A new, 15-year-long study, published online yesterday in PLoS Medicine , followed 6,441 men and women-both with and without the condition-in the National Heart, Lung and Blood Institute's large Sleep Heart Health Study to see if there was any correlation between apnea and a higher risk of death. (scientificamerican.com)
  • Our study does not prove that women are not at risk,' says Naresh Punjabi , lead study author and an associate professor of medicine at The Johns Hopkins Hospital in Baltimore. (scientificamerican.com)
  • It's long been believed that sleep apnea increases the rate of death,' says David Schulman , an assistant professor of medicine at Emory University in Atlanta who wasn't involved in the study, noting that those with apnea are more likely to have high blood pressure and elevated cholesterol. (scientificamerican.com)
  • The study determined that participants with low adherence to the AHEI increased their risk of cardiovascular and noncardiovascular death. (elsevier.com)
  • A second study in the same issue reviewed data on nearly 2,500 women and found the risk of death from any cause over up to four years was 65 percent higher with the less-invasive operation. (reuters.com)
  • Similar less-invasive surgery is used to treat endometrial, ovarian and uterine cancers, but for those malignancies, studies have shown that minimally-invasive surgery does not pose a higher risk of complications, death or tumor recurrence, noted Dr. Jason Wright, chief of gynecologic oncology at Columbia University Irving Medical Center and New York-Presbyterian Hospital in New York City and a coauthor of the second study. (reuters.com)
  • In the retrospective database study, four-year death rates were 5.3 percent with conventional "open" surgery and 9.1 percent with minimally-invasive surgery. (reuters.com)
  • Soy - A new study suggests that eating plant protein can lower your risk of death, while eating meat is associated with an increased risk of death. (cnn.com)
  • PATIENTS: A total of 596 patients in nontraumatic coma enrolled in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT), including 247 in the model derivation set and 349 in the model validation set. (rand.org)
  • The study, commissioned by the government in April at the height of the U.K. outbreak, found that people of Bangladeshi ethnicity had about twice the risk of death from the virus as white Britons. (click2houston.com)
  • The study did not take account of factors such as obesity - which increases the risk of death from the coronavirus - or the occupations of those who have died. (click2houston.com)
  • The study confirmed that the biggest risk factor with COVID-19 is age, with people aged 80 or over 70 times more likely to die from the virus than those aged under 40. (click2houston.com)
  • New evidence underscores the importance of eating breakfast every day, according to a study published today in the Journal of the American College of Cardiology that showed skipping breakfast was significantly associated with an increased risk of death from heart disease. (news-medical.net)
  • A study of more than 240,000 deaths in Queensland over more than a decade has found even low levels of air pollution raises the risk of dying. (brisbanetimes.com.au)
  • The Monash University study looked at Queensland's causes of death for a 15-year period to 2013, to examine whether even cities with relatively clean air, such as Brisbane, were adversely affected by air pollution. (brisbanetimes.com.au)
  • The study found that for every rise of one microgram per cubic metre (ug/m3) of particles 2.5 microns or smaller, there was a corresponding 2 per cent increase in the risk of dying. (brisbanetimes.com.au)
  • Professor Yuming Guo from Monash University's school of public health and preventive medicine said the link between high levels of air pollution and an increased risk of dying had already been established, but the study confirmed that very low levels were also a risk. (brisbanetimes.com.au)
  • Sleep-disordered breathing (also known as sleep apnea) is associated with an increased risk of death, according to new results from the Wisconsin Sleep Cohort, an 18-year observational study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. (emaxhealth.com)
  • The Wisconsin Sleep Cohort is the most comprehensive assessment yet of mortality risks associated with sleep-disordered breathing and the first to study a randomly selected population of adults in the United States. (emaxhealth.com)
  • Men who continued to smoke after a cancer diagnosis had an increased risk of death compared with those who quit smoking after diagnosis, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. (innovations-report.com)
  • Tao and colleagues used data from the Shanghai Cohort Study, which is a prospective cohort study investigating the association between lifestyle characteristics and risk of cancer among middle-aged and older men in Shanghai, China. (innovations-report.com)
  • SUNDAY, Dec. 2, 2018 (HealthDay News) -- The risk of sudden unexpected death in people with epilepsy can change over time, and it usually changes for the better, a new study reports. (healthday.com)
  • In what the researchers are calling hopeful news, the study found that people who have a medium or high risk of sudden unexpected death in epilepsy (SUDEP) often don't remain at the same risk level. (healthday.com)
  • Ayub, a clinical fellow at Massachusetts General Hospital and Harvard Medical School, said the study wasn't able to tease out why risk levels changed, but one reason may be a change in epilepsy treatment. (healthday.com)
  • That's the finding from a new Swedish study published on Friday in the journal Scientific Reports which states that dog ownership is associated with a reduced risk for cardiovascular disease and death. (northernstar.com.au)
  • A very interesting finding in our study was that dog ownership was especially prominent as a protective factor in persons living alone,' said study author Tove Fall, 'which is a group reported previously to be at higher risk of cardiovascular disease and death than those living in a multi-person household. (northernstar.com.au)
  • The same study found that when patients are treated with Avastin and certain chemotherapy drugs - taxanes or platinum medications - risks for fatal Avastin side effects like bleeding, blood clots, and bowel perforations may triple. (newsinferno.com)
  • RxPG] Care at a trauma center lowers by 25 percent the risk of death for injured patients compared to treatment received at non-trauma centers, according to the results of a nationwide study conducted by researchers at the Johns Hopkins Bloomberg School of Public Health and the University of Washington School of Medicine. (rxpgnews.com)
  • Proton pump inhibitors, used by millions to quell stomach acid, are associated with a higher risk of death, one observational study suggests. (cbsnews.com)
  • Some heartburn drugs used by millions of Americans are associated with a higher risk of death, a new study suggests, but people on the drugs should talk with their doctor first before stopping the medicines, experts say. (cbsnews.com)
  • We started thinking, if this is really true that PPIs are associated with all of these adverse events, does that translate to a higher risk of death, an increased risk of mortality," study author Dr. Ziyad Al-Aly told CBS News. (cbsnews.com)
  • The authors found that opium usage was associated with an 86% greater risk of death from several causes, including asthma , COPD (chronic obstructive pulmonary disease), TB ( tuberculosis ), cancer and circulatory diseases. (medicalnewstoday.com)
  • When researchers analyzed data from 31 studies involving nearly 28,000 men and 14,000 women, they found male gender to be an independent risk factor for death from heart failure. (medicinenet.com)
  • Most of the reduced risk was found for colorectal, stomach, and esophageal cancers. (medicinenet.com)
  • Andrew Odegaard, a University of Minnesota postdoctoral researcher, senior author Mark Pereira of the University of Minnesota School of Public Health, and colleagues at the National University of Singapore, found eating fast-food two or more times a week increased the risk of developing type 2 diabetes by 27 percent. (upi.com)
  • The researchers found that in the analyses adjusted for sex and year of birth, those with the lowest socioeconomic position had a 1.6 times higher risk of death from all causes than those with the highest socioeconomic position. (redorbit.com)
  • Using data from 148 studies conducted in several countries, Walker and colleagues found that the death rate for people with mental disorders was, on average, 2.22 times higher than that of people in the general population. (livescience.com)
  • In the full sample, a statistically significant, positive dose-response relationship was found between social isolation and mortality risk over the 30-year follow-up period. (psychcentral.com)
  • They found no link between marijuana use and death from heart disease or cerebrovascular disease. (healthcentral.com)
  • The researchers found those in the highest quarter, eating greater than four servings of ultraprocessed food each day, had the greatest risk for all-cause mortality compared to those in the lowest quarter. (mercola.com)
  • And the investigators found that sudden death, cardiac arrest, and trauma-related death during triathlons are not rare. (hon.ch)
  • Overall, risk of dying during a triathlon was 1.74 for every 100,000 athletes -- the equivalent of about five triathlete deaths a year, investigators found. (hon.ch)
  • A diet with more fiber and whole grains may mean a lower risk of death and disease, a new analysis commissioned by the World Health Organization has found. (usatoday.com)
  • It found that the risk of death in patients using the tiotropium Respimat inhaler was 52 percent higher than patients who used a placebo. (foxnews.com)
  • And surgery roughly doubled patients' risk of developing heart problems or dying of other causes, doctors found. (nydailynews.com)
  • We found higher estimated cardiovascular risks associated with marijuana use than cigarette smoking. (yahoo.com)
  • It was found that women who gave birth early (aged 20 years or less) or later in life (aged 31 years or more) had a higher risk of death compared to those who gave birth when aged 26 to 30 years old. (biomedcentral.com)
  • It was also found that there was a reduced risk of death in women who had breastfed compared to those who did not. (biomedcentral.com)
  • A sub-analysis found a link between women that have given birth and breastfed and a reduced risk of death from ischemic heart disease. (biomedcentral.com)
  • Then, after the 2015 tests had found potentially deadly problems - especially but not exclusively for pilots weighing less than 165 pounds - Air Force Lt. Gen. Christopher Bogdan, the former program manager, repeatedly downplayed the risk, as in October 2015 testimony to a House panel and subsequent comments to reporters. (rollcall.com)
  • We found that both habits, sitting for many hours in a day and sitting for long uninterrupted periods, were linked to an increased risk of death, regardless of whether a person exercised," Diaz said. (courthousenews.com)
  • People with obesity who commute by car were found to have a 32% increased risk of death, compared with those people with a normal weight and commute via cycling and walking, revealed new research presented at this year's European Congress on Obesity in Glasgow, Scotland (28 April - 1 May). (medindia.net)
  • Scientists at Charles Sturt University in Australia have found that the presence of anemia in patients with chronic heart failure is associated with a significantly increased risk of death. (medindia.net)
  • After adjusting for age, race, body mass index (BMI) and smoking, the authors found that men ages 40 to 70 with severe apnea (defined as more than 30 incidents of disrupted breathing 10 seconds or longer per hour-8.2 percent of the cohort's men) had about one and a half times higher risk of dying from any cause than those who did not. (scientificamerican.com)
  • In an interesting twist, Wright's team found that women who were not white, not privately insured and lived in areas with lower average incomes and lower education levels were more likely to have undergone "open" surgery, with its longer recovery time, greater risk of blood loss and other drawbacks. (reuters.com)
  • The researchers found that associations between protein intake and risk of death were confined to participants who had at least one unhealthy lifestyle habit or ailment, such as smoking, heavy drinking, obesity or physical inactivity. (cnn.com)
  • What we found is that even very low levels of air pollution can have a serious effect on health and hasten death," Professor Guo said. (brisbanetimes.com.au)
  • If, as we've found, there is an increased risk of mortality associated with levels of air pollution below this quality standard, that is a new risk for human health," he said. (brisbanetimes.com.au)
  • After three years, about 41 percent of those in the high-risk group remained in that category and just 5 percent in the medium-risk category stayed in the same risk group, researchers found. (healthday.com)
  • Previous studies have found reduced risk of certain health issues, like asthma and allergies, in kids who grow up with a dog. (northernstar.com.au)
  • They found a 25 percent increased risk of death in the patients who took a PPI compared with the people who took H2 blockers - about one extra death for every 500 people taking PPIs for a year. (cbsnews.com)
  • The researchers found a "graded" relationship, meaning the longer patients took the medication - for 30 days, 60 days, 90, 120 days, a year and so on - the higher their risk of death. (cbsnews.com)
  • It would have been more interesting if they had looked at the biological pathways and shown why or how conflicts had an effect on mortality risk," she said. (bbc.com)
  • This was a systematic review that pooled the findings of prospective cohort studies in a meta-analysis to try to better establish whether eating wholegrains is linked with mortality risk. (www.nhs.uk)
  • The authors wonder what the long-term health risks might be for patients prescribed opioids for chronic pain treatment. (medicalnewstoday.com)
  • Cell death: Is our health at risk? (medicalnewstoday.com)
  • But cell death can have side effects, and if it malfunctions, our health is at stake. (medicalnewstoday.com)
  • According to the report, published today in the Journal of Public Health, lack of health insurance was a factor in the death of as many as 45,000 people in 2005. (go.com)
  • In fact, the risk factor is 2.5 times higher than a 2002 estimate from the Institute of Medicine (IOM), which that suggested about 18,000 people between the ages of 25 and 64 die per year because of lack of health insurance. (go.com)
  • The authors also said the increased risk of death attributable to lack of insurance suggests that alternative measures of medical care for uninsured people, such as community health centers, do not protect against fatal medical issues as effectively as private health insurance. (go.com)
  • The findings are based on National Center for Health Statistics data from 1999 to 2014, during which the U.S. death rate from reported drug overdoses nearly quadrupled. (aarp.org)
  • They add that because bevacizumab is increasingly used in cancer patients, it is particularly important for all health care practitioners and patients to understand and recognize the risk of treatment-related mortality and to monitor closely to identify and treat serious adverse effects. (redorbit.com)
  • When people think about the risk of death for people with mental health problems, they often focus on suicide because it's so tragic and traumatic," Olfson told Live Science. (livescience.com)
  • But people with mental health disorders face many other health problems - such as high rates of smoking, poor diet, lack of exercise and a lack of medical care - that can lead to an early death, Olfson said. (livescience.com)
  • The risk to health from chemical particles in the air remained the same regardless of location or nearly any social or economic circumstance. (upi.com)
  • Our data add to a growing body of evidence that particulate matter is really harmful to health, increasing overall mortality, mostly deaths from cardiovascular disease, as well as deaths from respiratory disease in nonsmokers," said George Thurston, a professor of population health and environmental medicine at NYU Langone, in a press release. (upi.com)
  • It is especially important to continue monitoring health risks as national standards for air pollution are strengthened. (upi.com)
  • Race and ethnicity are risk markers for other underlying conditions that affect health including socioeconomic status, access to health care, and exposure to the virus related to occupation, e.g., frontline, essential, and critical infrastructure workers. (cdc.gov)
  • But it is not just the mothers that are putting their health at risk. (marieclaire.co.uk)
  • Quitting at any age provides a whole host of health and other benefits and quitting by age 45 avoids about 90 per cent of the cardiovascular risks of smoking. (news-medical.net)
  • Researchers reviewed data from 6,255 patients who participated in the second National Health and Nutrition Examination Survey (NHANES 2) from 1976 through 1980 and had causes of death documented over an average of 13 years. (scienceblog.com)
  • Some surgery centers are accused of overlooking high-risk health problems and treat patients who experts say should be operated on only in hospitals, if at all. (businessinsider.com)
  • LONDON (Reuters) - British people should eat less to lose weight as being obese increases the risk of dying from the novel coronavirus, junior health minister Helen Whately said on Monday. (reuters.com)
  • Reuters Health) - After a hip fracture, men are more cognitively impaired - and therefore, more at risk of death - than women, researchers in Baltimore say. (reuters.com)
  • Orthopedic surgeon Dr. John Tiberi of the Kerlan-Jobe Orthopaedic Clinic in Los Angeles, California told Reuters Health, "Hip fractures in the elderly are known to have significant risks, even after appropriate treatment. (reuters.com)
  • Further studies are needed to confirm these findings and clarify the mechanisms that link these risks, which could then help in the development of new strategies to improve the long-term health of women. (biomedcentral.com)
  • To determine the health risks of extended sedentary time, a team of researchers studied nearly 8,000 black and white adults ages 45 and older and measured both their total and average lengths of sedentary time. (courthousenews.com)
  • Inadequate oversight combined with global manufacturing and easy Internet distribution has Cohen and other experts worried that the risk of purchasing supplements laced with untested ingredients, banned substances or prescription drugs is a serious public health concern. (runnersworld.com)
  • Each year, college drinking contributes to an estimated 1,400 student deaths, 500,000 injuries, and 70,000 cases of sexual assault or date rape, according to the National Institute on Alcohol Abuse and Alcoholism, a part of the federal National Institutes of Health. (go.com)
  • The health outcomes of interest were death from any cause, death due to heart disease and hospital admission due to non-fatal heart disease. (medindia.net)
  • Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. (medindia.net)
  • Brief periods of interrupted breathing during sleep affect an estimated 10 to 25 percent of people in the U.S. A smattering of studies have linked the condition, known as obstructive sleep apnea, to a host of serious health risks, such as cardiovascular disease, obesity and even accidents-but long-term, population-based data on mortality overall have been lacking. (scientificamerican.com)
  • Health Secretary Matt Hancock said it was inarguable that "being black or from a minority ethnic background is a major risk factor" in the pandemic. (click2houston.com)
  • The risk of death was linked to the severity of sleep-disordered breathing and was not attributable to age, gender, body mass index (an indicator of overweight or obesity), or cardiovascular health status. (emaxhealth.com)
  • Michael J. Twery, PhD, director of the NHLBI National Center on Sleep Disorders Research, is available to comment on these findings, as well as on associated health risks of sleep-disordered breathing, and the importance of diagnosing and treating the condition. (emaxhealth.com)
  • With so many studies associating PPIs with other health risks, researchers from Washington University School of Medicine in St. Louis wanted to find out if people who took the drugs were at greater risk of dying. (cbsnews.com)
  • It's not clear why PPIs are linked to a higher risk for some health conditions, said May, but theories include the possibility that less gastric acid production changes the environment of the stomach and lower bowel and may affect how other drugs a patient may be taking - such as a heart medication - are metabolized. (cbsnews.com)
  • CHICAGO (Reuters) - Beta carotene and vitamins A and E, antioxidant supplements taken by millions to fight disease, may actually raise the risk of death, a review of 68 studies on nearly a quarter-million people said on Tuesday. (reuters.com)
  • Reuters) - Pfizer Inc's antibacterial drug Tygacil increases the risk of death whether used as authorized by the U.S. Food and Drug Administration or for unapproved conditions, the agency warned on Friday. (reuters.com)
  • Of the 135 fatalities, cardiac arrest and sudden death were the most common causes: 90 occurred during the swim portion, 15 while running and seven while bicycling. (hon.ch)
  • Automatic detection and transvenous or subcutaneous defibrillation of malignant ventricular arrhythmias by implantable cardioverter defibrillators are vital for management of patients at high risk for sudden cardiac death. (ahajournals.org)
  • Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which occur during physical activity. (sun-sentinel.com)
  • Sudden cardiac death most often occurs as the result of ventricular fibrillation (VF), an abrupt irregular heart rhythm that causes the heart to quiver inneffectively rather than pumping normally. (sun-sentinel.com)
  • In lacrosse and other sports such as baseball and hockey, however, another unpredictable and relatively uncommon source of cardiac death has been recognized - commotio cordis. (sun-sentinel.com)
  • While commotio cordis is rare, most young athletes who die of sudden cardiac death have an underlying cardiac abnormality. (sun-sentinel.com)
  • Those who have a family history of one of these disease states or of unexplained sudden death should undergo a cardiac evaluation before participation in athletics. (sun-sentinel.com)
  • These players have a higher than normal risk of sudden, potentially fatal heart rhythm disturbances or cardiac arrest, when the heart stops beating. (hopkinsmedicine.org)
  • But African-Americans are more vulnerable, with two to three times the rate of sudden cardiac death than in whites. (hopkinsmedicine.org)
  • The checkup will include a basic questionnaire to review any past history of chest pain, shortness of breath, fainting spells, instances of sudden cardiac death in relatives, weight and blood pressure measurements, and tests for unusual heartbeats or murmurs. (hopkinsmedicine.org)
  • Young athletes and their parents should feel secure in pursuing physical fitness to the best of their children's abilities and without the unknown risk from sudden cardiac death," says Abraham, an associate professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute. (hopkinsmedicine.org)
  • If there had been better understanding and appreciation for the risks involved with these heart abnormalities, Abraham says, it may have saved the life of Baltimore native Reggie Lewis, 27, a basketball player for the Boston Celtics, who in the summer of 1993 dropped dead on the court from cardiac arrest, likely triggered by an overly enlarged and thickened heart. (hopkinsmedicine.org)
  • Cerati D, Schwartz P (1991) Single cardiac nerve fibre activity, acute myocardial ischaemia and sudden death. (springer.com)
  • A fatal adverse event (FAE) is defined as a death caused in all likelihood by a drug and is a major cause of fatality in the United States. (redorbit.com)
  • Mannequin tests in 2015 had demonstrated that some F-35 pilots were at risk of fatal neck injuries if they had to eject in the original seats under some emergency conditions. (rollcall.com)
  • Methadone and buprenorphine reduced the risk of death by about half for people who'd previously had a non-fatal opioid overdose. (nih.gov)
  • But people who experience a non-fatal overdose are at increased risk of a later fatal overdose. (nih.gov)
  • But whether they can reduce the risk of death after a non-fatal opioid overdose hasn't been clear. (nih.gov)
  • Those smokers have around triple the risk of dying from cardiovascular disease compared to people who have never smoked, and double the risk of a heart attack, a stroke or heart failure. (news-medical.net)
  • People who ate the most wholegrain food had a 16% lower chance of dying during the studies, compared to people who ate the least wholegrain food ( relative risk [RR] 0.84, 95% confidence interval [CI] 0.8 to 0.88), and had a 18% lower chance of dying from cardiovascular disease (RR 0.82, 95% CI 0.79 to 0.85). (www.nhs.uk)
  • 3 Data source: NCHS provisional death counts ( https://data.cdc.gov/NCHS/Deaths-involving-coronavirus-disease-2019-COVID-19/ks3g-spdg , data through January 30, 2021). (cdc.gov)
  • Men who walked more than 90 minutes per week at a normal to brisk pace had a 46% lower risk of dying from any cause compared to men who walked less than 90 minutes per week. (webmd.com)
  • Men who reported vigorous activity for at least three hours per week had a 61% lower risk of a prostate cancer-specific death, compared with men who exercised for less than an hour per week. (webmd.com)
  • Most important, scoring higher on the lifestyle score was associated with a lower risk of all-cause mortality, report investigators in their paper, published online June 4, 2013 in the American Journal of Epidemiology . (medscape.com)
  • Individuals who adopted all four healthy behaviors had an approximate 80% lower risk of death than those with no healthy behaviors. (medscape.com)
  • Cite this: Four Healthy Lifestyle Behaviors Lower Risk of Death, Slow CAC Progression - Medscape - Jun 04, 2013. (medscape.com)
  • In our analysis, daily aspirin use was associated with about a 16% lower risk of dying from cancer overall," Jacobs says. (medicinenet.com)
  • There was a weaker link to a lower risk of dying from cancer. (www.nhs.uk)
  • Previous work, using UK Biobank data, has shown that active commuting, mainly cycling, was associated with a 50% lower risk of death, from any cause, and heart disease compared to car commuting. (medindia.net)
  • runners also faced a 45% lower risk of death from cardiovascular disease, according to a press release . (newser.com)
  • Comparatively, the top fifth of white meat consumers had a slightly lower risk for death than those who ate the least white meat. (health24.com)
  • Why animal protein is linked to mortality and plant protein is linked to a lower risk of death remains largely a mystery, Song said. (cnn.com)
  • However, previous research has shown links between higher consumption of fried foods and an increased risk of Type 2 diabetes and heart disease. (cnn.com)
  • Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabetes and cardiovascular disease. (medindia.net)
  • Homeless people are at high risk for illness and have higher death rates than the general population. (cmaj.ca)
  • People who use opium have a considerably higher risk of dying from any cause, especially from cancer , respiratory conditions, and circulatory disease, researchers from Tehran University of Medical Sciences, Tehran, Iran, reported in the BMJ (British Medical Journal) . (medicalnewstoday.com)
  • The finding comes amid efforts to develop better treatments for asthma, which affects around five million people in the UK, causing some 1,400 deaths every year. (netdoctor.co.uk)
  • The researchers drew their conclusions after looking at death rates in more than 100,000 people who had suffered one heart attack. (telegraph.co.uk)
  • Following revelations of Magnano's death, he told CNN, 'Unfortunately, the things we're saying about this type of surgery keep being proven right by people having major disasters. (cnn.com)
  • People still need to check with their doctor if they are at risk for asthma, bronchitis, or COPD before flying in that region," he said. (foxnews.com)
  • Hypoglycemia is clearly an under-recognised risk factor for death and cardiovascular disease in people with diabetes. (yahoo.com)
  • Previous research suggests people with high levels of anxiety and demands from partners and children, and those who often argue with close family members, could be at a higher risk of heart disease and strokes. (bbc.com)
  • But she added that people who were always or often involved in conflicts were at greatest risk, and could be helped. (bbc.com)
  • (CNN) -- A government researcher said Monday that experimental blood substitutes are linked to an increased risk of heart attack and death, and suggested that studies on people should be halted. (cnn.com)
  • But the benefit was small - 167 people would need to use Praluent for nearly three years to prevent a single death. (foxbusiness.com)
  • The new drugs clearly help people at high risk and are not aimed at people at low risk, such as those who have high cholesterol but have never had a heart attack, he said. (foxbusiness.com)
  • Praluent's makers say they will aim for those price ranges for insurers that remove barriers to coverage for people at the highest risk. (foxbusiness.com)
  • A lot of people underestimate the risks of light smoking,' said Professor Banks. (news-medical.net)
  • Younger people who have metabolic syndrome should be aware of the risk, particularly those who have diabetes and high blood pressure. (eurekalert.org)
  • We can't be sure that all the reduced risk is solely down to eating wholegrain food, as people who eat wholegrain may also have other patterns of healthy behaviour, such as exercising regularly, avoiding smoking and sticking to the recommended guidelines for alcohol consumption. (www.nhs.uk)
  • The people who reported high levels of animal protein consumption and were most at risk for death from heart disease were also overweight, more sedentary, consumed alcohol, or smoked. (everydayhealth.com)
  • The results highlight missed opportunities to help people at high risk of death from opioid use. (nih.gov)
  • People with a recent cancer diagnosis were excluded because of their higher risk of death overall. (nih.gov)
  • The government didn't offer any solutions, prompting concerns that people from black, Asian and other minority backgrounds will still face a disproportionate risk if there is a second spike in the coronavirus outbreak. (click2houston.com)
  • One of the things we saw that was kind of scary is that although we can tell people what their risk is, there was no long-term outlook. (healthday.com)
  • People with zero were placed in the low-risk category. (healthday.com)
  • And people who had three or more generalized seizures annually were considered at high risk of SUDEP. (healthday.com)
  • Another is that none of the people actually had a SUDEP event, making it difficult to capture the actual risk, he said. (healthday.com)
  • The results were most robust in single people: For these individuals, dog ownership was linked to a 33 per cent reduced risk of mortality from any cause (it was 11 per cent for multiple-person households), compared to non-owners. (northernstar.com.au)
  • Heart attack-related death was reduced by 36 per cent for single people, compared to 15 per cent for non-single. (northernstar.com.au)
  • People who live alone have been shown previously to be at a higher risk of cardiovascular death. (northernstar.com.au)
  • They looked at data on 275,933 people who had been prescribed a PPI and 73,355 who'd been prescribed an H2 blocker between October 2006 and September 2008, tracking deaths up to five years. (cbsnews.com)
  • The difference may sound small, but considering millions of people take PPIs, Al-Aly said, "It's a small but significant risk. (cbsnews.com)
  • Some people who are at a higher risk for cancer can also benefit from PPIs, said May. (cbsnews.com)
  • Braat studied deaths between 1984 and 2008 for the research, identifying that 17 women who had died in pregnancy had undergone IVF treatment, forming a death rate of 42.5% for every 100,000 pregnancies, compared with 12.1 in every 100,000 for women who had conceived naturally. (marieclaire.co.uk)
  • As of Febru- ary 28, 2020, the cumulative number of reported deaths in basic strategies available to mitigate disease spread in China was 2,858. (cdc.gov)
  • In China, the cumulative number suming that ascertainment bias is consistent, we can of reported deaths was 2,858 as of February 28, 2020, adjust for right censoring by using established meth- a figure that already dwarfed the number of persons ods and available data ( 6 , 7 ). (cdc.gov)
  • Our analysis relies on epidemi- have died with biased death risk is shown in the mid- ologic data reported through February 11, 2020, because dle parenthetical term, and the contribution of sur- of the change in case definition that was announced by vivors is shown in the right parenthetical term. (cdc.gov)
  • We report mortality rates and causes of death in a cohort of women who used homeless shelters in Toronto. (cmaj.ca)
  • The top three causes of death were accidents, self-injury, and circulatory for those ages 12 to 25, cancer, circulatory, and accidental for those ages 26 to 32, and cancer, circulatory, and genetic for those ages 33 to 39. (medpagetoday.com)
  • Using public data to do its calculations, the website also listed the possible causes of death, including illnesses or accidents. (wikipedia.org)
  • Longer total and average sedentary time were both associated with higher risk for all causes of death, with the connection being dose-dependent. (courthousenews.com)
  • Cause-of-death distributions are estimated from death registration data, and data from population-based epidemiological studies, disease registers and notifications systems for selected specific causes of death. (wikipedia.org)
  • But when flu symptoms strike, the antiviral drugs Tamiflu and Relenza pose vastly less risk than the flu itself. (webmd.com)
  • Although the American Academy of Pediatrics advises that infants do not need to be repositioned onto their backs if they roll into the prone position, parents need to be reminded that cribs and bassinets should be clear of any objects, so that if the infant rolls, there is no risk of rolling into soft or loose bedding or objects that may pose a suffocation risk, Colvin says. (usatoday.com)
  • The F-35 fighter jets' flawed ejection seats, which Air Force officials said in May had been fixed, still pose a "serious" risk that will probably injure or kill nearly two dozen pilots, according to an internal Air Force safety report that service officials withheld from the press. (rollcall.com)
  • But energy-enhancing pills, powders and drinks targeted to gym rats and endurance competitors may also pose risks. (runnersworld.com)
  • The agency said at the time it had analyzed pooled clinical trial data and determined that most deaths were related to progression of the infection. (reuters.com)
  • We used regression risk analysis to quantify the association between clinical correlates and death. (nih.gov)
  • Nigel Mercer, president of the British Association of Aesthetic Plastic Surgeons, last month described the cosmetic surgery industry an 'unregulated mess' in the journal Clinical Risk. (cnn.com)
  • Punjabi and others look forward to formal clinical trials, in which researchers can start testing methods of intervention and treatment to see if they can bring the risk of mortality in check. (scientificamerican.com)
  • CONCLUSIONS: Five readily available clinical variables identify a large subgroup of patients in nontraumatic coma at high risk for poor outcomes. (rand.org)
  • Previous studies have suggested that opium might raise the risk of developing bladder and throat cancers, coronary heart disease , as well as some other conditions and illnesses. (medicalnewstoday.com)
  • Researchers at the American Cancer Society note that social isolation was associated with a higher risk of death from all causes, including heart disease, for all races studied. (psychcentral.com)
  • A person's social isolation score was positively associated with death from heart disease in all subgroups. (psychcentral.com)
  • It is particularly interesting that patients with even one or two metabolic syndrome traits, or those with the metabolic syndrome but without diabetes were at increased risk for death from coronary heart disease and cardiovascular diseases," said Nathan D. Wong, Ph.D., professor and director of the Heart Disease Prevention Program, division of cardiology at the University of California, Irvine. (scienceblog.com)
  • There was however, no association between marijuana use and death from heart disease or cerebrovascular disease. (yahoo.com)
  • Many of these associations were also apparent when we considered cause-specific deaths from total cancer and ischemic heart disease. (biomedcentral.com)
  • 95% CI = 1.1-1.9) increased the risk for sudden coronary heart disease death. (nih.gov)
  • However, the risk of heart disease was still increased by 82% in active commuters with obesity compared with normal weight active commuters. (medindia.net)
  • And weight loss through diet certainly has significant benefits, including lowering your risk of developing high blood pressure , heart disease, diabetes , some cancers, and sleep apnea . (everydayhealth.com)