Ribosomal proteins. Medical search

Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits.

A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE.

Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION.

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

Proteins found in any species of bacterium.

The large subunit of the 80s ribosome of eukaryotes. It is composed of the 28S RIBOSOMAL RNA, the 5.8S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 50 different RIBOSOMAL PROTEINS.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

The small subunit of the 80s ribosome of eukaryotes. It is composed of the 18S RIBOSOMAL RNA and 32 different RIBOSOMAL PROTEINS.

A species of GRAM-POSITIVE ENDOSPORE-FORMING BACTERIA in the family BACILLACEAE, found in soil, hot springs, Arctic waters, ocean sediments, and spoiled food products.

A species of gram-negative, aerobic, rod-shaped bacteria found in hot springs of neutral to alkaline pH, as well as in hot-water heaters.

Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I. (Singleton & Sainsbury, Dictionary of Microbiology & Molecular Biology, 2d ed)

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.

A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

The functional hereditary units of FUNGI.

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

A group of uridine ribonucleotides in which the phosphate residues of each uridine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.

The largest ribonucleoprotein component of RIBOSOMES. It contains the domains which catalyze formation of the peptide bond and translocation of the ribosome along the MESSENGER RNA during GENETIC TRANSLATION.

The small subunit of eubacterial RIBOSOMES. It is composed of the 16S RIBOSOMAL RNA and about 23 different RIBOSOMAL PROTEINS.

Protein factors uniquely required during the elongation phase of protein synthesis.

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

The functional hereditary units of BACTERIA.

Proteins obtained from ESCHERICHIA COLI.

Plant cell inclusion bodies that contain the photosynthetic pigment CHLOROPHYLL, which is associated with the membrane of THYLAKOIDS. Chloroplasts occur in cells of leaves and young stems of plants. They are also found in some forms of PHYTOPLANKTON such as HAPTOPHYTA; DINOFLAGELLATES; DIATOMS; and CRYPTOPHYTA.

Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.

A genus of HALOBACTERIACEAE whose growth requires a high concentration of salt. Binary fission is by constriction.

The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.

Constituent of the 40S subunit of eukaryotic ribosomes. 18S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.

One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.

The small ribonucleoprotein component of RIBOSOMES. It contains the MESSENGER RNA binding site and two TRANSFER RNA binding sites - one for the incoming AMINO ACYL TRNA (A site) and the other (P site) for the peptidyl tRNA carrying the elongating peptide chain.

Proteins found in any species of fungus.

The sum of the weight of all the atoms in a molecule.

A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.

The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.

Complexes of RNA-binding proteins with ribonucleic acids (RNA).

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.

A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.

The rate dynamics in chemical or physical systems.

Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.

An oligosaccharide antibiotic produced by various STREPTOMYCES.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. It includes cleavage, methylation, thiolation, isopentenylation, pseudouridine formation, conformational changes, and association with ribosomal protein.

The two dissimilar sized ribonucleoprotein complexes that comprise a RIBOSOME - the large ribosomal subunit and the small ribosomal subunit. The eukaryotic 80S ribosome is composed of a 60S large subunit and a 40S small subunit. The bacterial 70S ribosome is composed of a 50S large subunit and a 30S small subunit.

A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.

A process of GENETIC TRANSLATION, when an amino acid is transferred from its cognate TRANSFER RNA to the lengthening chain of PEPTIDES.

A species of halophilic archaea distinguished by its production of acid from sugar. This species was previously called Halobacterium marismortui.

The large subunit of the eubacterial 70s ribosome. It is composed of the 23S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 37 different RIBOSOMAL PROTEINS.

Esters of the hypothetical imidic acids. They react with amines or amino acids to form amidines and are therefore used to modify protein structures and as cross-linking agents.

Protein factors uniquely required during the initiation phase of protein synthesis in GENETIC TRANSLATION.

Deoxyribonucleic acid that makes up the genetic material of fungi.

Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.

A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of bacterial ribosomes by a process linked to hydrolysis of GTP to GDP.

Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.

Constituent of the 60S subunit of eukaryotic ribosomes. 28S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

The relationships of groups of organisms as reflected by their genetic makeup.

Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.

Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.

Proteins found in any species of archaeon.

Any method used for determining the location of and relative distances between genes on a chromosome.

Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. (1/4527)

Down-regulation of the Drosophila ribosomal protein S21 gene (rpS21) causes a dominant weak Minute phenotype and recessively produces massive hyperplasia of the hematopoietic organs and moderate overgrowth of the imaginal discs during larval development. Here, we show that the S21 protein (RpS21) is bound to native 40S ribosomal subunits in a salt-labile association and is absent from polysomes, indicating that it acts as a translation initiation factor rather than as a core ribosomal protein. RpS21 can interact strongly with P40, a ribosomal peripheral protein encoded by the stubarista (sta) gene. Genetic studies reveal that P40 underexpression drastically enhances imaginal disc overgrowth in rpS21-deficient larvae, whereas viable combinations between rpS21 and sta affect the morphology of bristles, antennae, and aristae. These data demonstrate a strong interaction between components of the translation machinery and showed that their underexpression impairs the control of cell proliferation in both hematopoietic organs and imaginal discs. (+info)

Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae. (2/4527)

Introns have typically been discovered in an ad hoc fashion: introns are found as a gene is characterized for other reasons. As complete eukaryotic genome sequences become available, better methods for predicting RNA processing signals in raw sequence will be necessary in order to discover genes and predict their expression. Here we present a catalog of 228 yeast introns, arrived at through a combination of bioinformatic and molecular analysis. Introns annotated in the Saccharomyces Genome Database (SGD) were evaluated, questionable introns were removed after failing a test for splicing in vivo, and known introns absent from the SGD annotation were added. A novel branchpoint sequence, AAUUAAC, was identified within an annotated intron that lacks a six-of-seven match to the highly conserved branchpoint consensus UACUAAC. Analysis of the database corroborates many conclusions about pre-mRNA substrate requirements for splicing derived from experimental studies, but indicates that splicing in yeast may not be as rigidly determined by splice-site conservation as had previously been thought. Using this database and a molecular technique that directly displays the lariat intron products of spliced transcripts (intron display), we suggest that the current set of 228 introns is still not complete, and that additional intron-containing genes remain to be discovered in yeast. The database can be accessed at http://www.cse.ucsc.edu/research/compbi o/yeast_introns.html. (+info)

Purification and characterization of initiation factor IF-E2 from rabbit reticulocytes. (3/4527)

Initiation factor IF-E2 was isolated from rabbit reticulocytes and purified 120-fold to near homogeneity by ammonium sulfate fractionation, column chromatography on DEAE-cellulose and phosphocellulose, and, when suitable, by sucrose density gradient centrifugation. The factor is a complex protein containing three nonidentical polypeptides of molecular weight 57,000, 52,000, and 36,000. It behaves as a complex throughout its purification and during polyacrylamide gel electrophoresis in nondenaturing buffer but its thress components are readily separated by electrophoresis in denaturing buffers. None of its components corresponds to any of the polypeptides of the other initiation factors or to any proteins of ribosomes washed in buffers containing a high salf concentration. A stoichiometric ratio of 1:1:1 was determined for the three polypeptides; based on the assumption of one copy each per complex, the calculated factor molecular weight is 145,000, a value in agreement with the measured value of 160,000. Initiation factor IF-E2 was radioactively labeled in vitro by reductive alkylation or by phosphorylation with a protein kinase also isolated from rabbit reticulocytes. Neither procedure causes a measurable change in the ability of the factor to form a ternary complex with GTP and the initiator methionyl-tRNA. 5'-Guanylyl-methylenediphosphonate may substitute for GTP, but only at relatively high concentrations. The binding of labeled initiation factor IF-E2 and methionyl-tRNA to the 40 S ribosomal subunit was studied by sucrose density gradient centrifugation. Appreciable binding of the factor is seen only when all three components of the ternary complex are included in the reaction mixture. The binding of either the factor or methionyl-tRNA was not stimulated by the addition of globin messenger RNA and initiation factor IF-E3. It was shown that all three polypeptide components of initiation factor IF-E2 are bound to these nascent initiation complexes. (+info)

Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. (4/4527)

The proteins of the large subunit of rat liver ribosomes were separated into seven groups by stepwise elution from carboxymethylcellulose with LiCl at pH 6.5. Seventeen proteins (L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39) were isolated from three of the groups (B60, D60, G60) by ion exchange chromatography on carboxymethylcellulose and by filtration through Sephadex. The amount of protein obtained varied from 0.5 to 15 mg. Eight of the proteins (L9, L11, L13, L21, L22, L35', L37 and L39) had no detectable contamination; the impurities in the others were no greater than 9%. The molecular weight of the proteins was estimated by polyacrylamide gel electrophoresis in sodium dodecyl sulfate; the amino acid composition was determined. (+info)

Immunological comparison of the proteins of chicken and rat liver ribosomes. (5/4527)

A comparison of the proteins of chicken and rat liver ribosomes using immunochemical techniques was undertaken. The procedures included quantitative precipitation, passive hemagglutination, and immunodiffusion on Ouchterlony plates. The results indicate that antisera specific for chicken or rat liver ribosomes recognize only about 20% of common determinants. While there are important reservations, the results suggest extensive differences in the proteins of rat and chicken liver ribosomes. Despite those differences, rat and chicken liver ribosomal proteins maintain some homologous sequences present in bacterial ribosomal proteins. An enriched antibody preparation against chicken 80 S ribosomes inhibited the poly(U)-directed synthesis of polyphenylalanine and the elongation factor G (EF-G)-catalyzed binding of [3H]GDP to Escherichia coli ribosomes. Thus, chicken liver ribosomes, like ribosomes from rat liver and yeast, must have proteins homologous with those of E. coli ribosomes. (+info)

Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (6/4527)

The nuclear and nucleolar targeting properties of human ribosomal protein S25 (RPS25) were analysed by the expression of epitope-tagged RPS25 cDNAs in Cos-1 cells. The tagged RPS25 was localized to the cell nucleus, with a strong predominance in the nucleolus. At the amino terminus of RPS25, two stretches of highly basic residues juxtapose. This configuration shares common features with the nucleolar targeting signals (NOS) of lentiviral RNA-binding transactivators, including human immunodeficiency viruses' (HIV) Rev proteins. Deletion and site-directed mutational analyses demonstrated that the first NOS-like stretch is dispensable for both nuclear and nucleolar localization of RPS25, and that the nuclear targeting signal is located within the second NOS-like stretch. It has also been suggested that a set of continuous basic residues and the total number of basic residues should be required for nucleolar targeting. Signal-mediated nuclear/nucleolar targeting was further characterized by the construction and expression of a variety of chimeric constructs, utilizing three different backbones with RPS25 cDNA fragments. Immunofluorescence analyses demonstrated a 17 residue peptide of RPS25 as a potential nuclear/nucleolar targeting signal. The identified peptide signal may belong to a putative subclass of NOS, characterized by compact structure, together with lentiviral RNA-binding transactivators. (+info)

Autoreactive human T cell lines recognizing ribosomal protein L7. (7/4527)

Sera of patients suffering from systemic lupus erythematosus (SLE) frequently contain oligoclonal IgG autoantibodies with high affinity for the ribosomal protein L7 (rpL7). The humoral autoimmune response to rpL7 apparently is driven by antigen and T cell dependent. In order to analyze the T cell response to rpL7 we cultured peripheral blood lymphocytes of healthy individuals and SLE patients in the presence of recombinant rpL7. After 10 days, the cytokine response to re-stimulation with rpL7 was examined using a spot-ELISA. Measuring IFN-gamma secretion, the T cells of two patients and four healthy donors showed a significant increase in the number of spots as compared to control cells. Secretion of IL-4 or IL-10 was not detected. From the antigen-stimulated primary cultures we established by limiting dilution cloning six rpL7-reactive, IFN-gamma-secreting T cell lines which show a CD3+CD4+CD8- phenotype. One line additionally was shown to be positive for HLA-DR and CD45R0, but negative for CD27 and CD31. The cell lines carry alphabeta TCR chains which differ from each other in sequence and specificity. rpL7 fragments rich in basic amino acids could be identified as epitopes recognized by the TCR of three cell lines. Recognition of rpL7 is HLA-DR6 restricted or respectively HLA-DP restricted in the two cell lines analyzed. (+info)

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (8/4527)

Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistant sublines of Chinese hamster V79 cells have now been isolated. In order to gain understanding of possible targets for arsenite's action, one arsenite-resistant subline, As/R28A, was chosen as a donor for a cDNA expression library. The library from arsenite-induced As/R28A cells was transfected into arsenite-sensitive As/S5 cells, and transfectants were selected for arsenite-resistance. Two cDNAs, asr1 and asr2, which confer arsenite resistance to arsenite-hypersensitive As/S5 cells as well as to wild-type cells, were isolated. asr1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin-like region fused to S30 ribosomal protein. Arsenite was previously shown to inhibit ubiquitin-dependent proteolysis. These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite. (+info)

A ribosomal protein (r-protein or rProtein) is any of the proteins that, in conjunction with rRNA, make up the ribosomal ... proteins of the eukaryotic small ribosomal subunit proteins are also present in archaea (no ribosomal protein is exclusively ... 30S Ribosomal proteins at biochem.umd.edu Ribosomal+Protein at the US National Library of Medicine Medical Subject Headings ( ... November 2012). "Inactivation of ribosomal protein genes in Bacillus subtilis reveals importance of each ribosomal protein for ...

https://en.wikipedia.org/wiki/Ribosomal_protein

40S ribosomal protein SA is a ribosomal protein that in humans is encoded by the RPSA gene. It also acts as a cell surface ... This protein has been variously called Ribosomal protein SA; RPSA; LamR; LamR1; 37 kDa Laminin Receptor Precursor; 37LRP; 67 ... i) Yeast two-hybrid screens have shown that RPSA binds to Ribosomal protein S21 of the 40S small ribosomal subunit. (ii) Serial ... The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin ...

https://en.wikipedia.org/wiki/Ribosomal_protein_SA

Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both ... Human 40S ribosomal protein S6) at the PDBe-KB. (Genes on human chromosome 9, Ribosomal proteins). ... Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse ... Ruvinsky I, Meyuhas O (June 2006). "Ribosomal protein S6 phosphorylation: from protein synthesis to cell size". Trends in ...

https://en.wikipedia.org/wiki/Ribosomal_protein_S6

... including ribosomal protein L20 leader and ribosomal S15 leader. Ribosomal leaders typically bind ribosomal proteins that ... UTR of mRNAs encoding a ribosomal protein. When cellular concentrations of the ribosomal protein are high, excess protein will ... which leads to the synthesis of more copies of the ribosomal protein. Many examples of ribosomal protein leaders are known in ... A ribosomal protein leader is a mechanism used in cells to control the cellular concentration of a protein that forms a part of ...

https://en.wikipedia.org/wiki/Ribosomal_protein_leader

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene. Mammalian mitochondrial ... Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24 ... Overview of all the structural information available in the PDB for UniProt: Q9BYD3 (39S ribosomal protein L4, mitochondrial) ... "Entrez Gene: MRPL4 mitochondrial ribosomal protein L4". Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L4

Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. GRCh38: ... Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas ... It encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N-terminus and ribosomal protein S30 at the C- ... ribosomal protein S30". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S30

39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene. Mammalian mitochondrial ... v t e v t e (Genes on human chromosome 6, All stub articles, Human chromosome 6 gene stubs, Protein stubs, Ribosomal proteins) ... This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in ... "Entrez Gene: MRPL18 mitochondrial ribosomal protein L18". Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L18

... is a protein that in humans is encoded by the RPL7 gene. Ribosomes, the organelles that catalyze ... The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like ... "Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7". The Journal of ... "Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7". The Journal of ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L7

An L17 ribosomal protein leader is a ribosomal protein leader involved in ribosome biogenesis. It is used as an autoregulatory ... The structure is located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L17 (rplQ). Ribosomal protein ... Page for Ribosomal L17 leader at Rfam v t e (Ribosomal protein leader, All stub articles, Molecular and cellular biology stubs) ... mechanism to control the concentration of the ribosomal protein L17. Known Examples were predicted in Actinomycetota and ...

https://en.wikipedia.org/wiki/L17_ribosomal_protein_leader

... is a protein that in humans is encoded by the RPS29 gene. Ribosomes, the organelles that catalyze ... This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal ... "Entrez Gene: RPS29 ribosomal protein S29". Mirabello L, Macari ER, Jessop L, Ellis SR, Myers T, Giri N, Taylor AM, McGrath KE, ... Kondoh N, Noda M, Fisher RJ, Schweinfest CW, Papas TS, Kondoh A, Samuel KP, Oikawa T (August 1996). "The S29 ribosomal protein ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S29

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene. Mammalian mitochondrial ... v t e v t e (Genes on human chromosome 4, All stub articles, Human chromosome 4 gene stubs, Protein stubs, Ribosomal proteins) ... This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. GRCh38: Ensembl release 89: ... Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24 ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L1

... referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins ... RPL24 ribosomal protein L24". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed ... 60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene. Ribosomes, the organelles that catalyze ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L24

An eL15 ribosomal protein leader is a ribosomal protein leader involved in ribosome biogenesis. It is used as an autoregulatory ... untranslated regions of mRNAs encoding ribosomal proteins eL15 (rpl15e). Similarities between the eL15 ribosomal protein and ... Page for Ribosomal eL15 leader at Rfam v t e (Ribosomal protein leader, All stub articles, Molecular and cellular biology stubs ... the rRNA site to which this protein binds were detected. Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal ...

https://en.wikipedia.org/wiki/EL15_ribosomal_protein_leader

Page for Ribosomal protein L10 leader at Rfam v t e (Ribosomal protein leader, All stub articles, Molecular and cellular ... Other ribosomal protein leaders identified in the same study include those of L13, L19, L20 and L21. Zengel JM, Lindahl L (1994 ... It is located in the 5′ untranslated regions of mRNAs encoding ribosomal proteins L10 and L12 (rplJ-rplL). A Rho-independent ... This family is a putative ribosomal protein leader autoregulatory structure found in B. subtilis and other low-GC Gram-positive ...

https://en.wikipedia.org/wiki/Ribosomal_protein_L10_leader

The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically ... "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic ... 60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene. Ribosomes, the organelles that catalyze ... "Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid". ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L6

RPL13A ribosomal protein L13a". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... 60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene. Ribosomes, the organelles that catalyze ... The protein belongs to the L13P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing ... 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509-23. doi:10.1101/gr.8.5.509. PMID 9582194. Higa S, ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L13a

... is a protein that in humans is encoded by the MRPL13 gene. Mammalian mitochondrial ... "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05. Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, ... ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes ... They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L13

39S ribosomal protein L40, mitochondrial is a protein that in humans is encoded by the MRPL40 gene. Mammalian mitochondrial ... v t e v t e (Genes on human chromosome 22, All stub articles, Human chromosome 22 gene stubs, Protein stubs, Ribosomal proteins ... 1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of ... "Entrez Gene: MRPL40 mitochondrial ribosomal protein L40". Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. ( ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L40

The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ... 40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene. Ribosomes, the organelles that catalyze ... Pei L (1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of ... Pei, L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S10

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene. Mammalian mitochondrial ... 1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of ... Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958-69. doi:10.1074/jbc.M106510200. PMID ... Overview of all the structural information available in the PDB for UniProt: Q7Z7H8 (39S ribosomal protein L10, mitochondrial) ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L10

RPS11 ribosomal protein S11". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... The protein belongs to the S17P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ... 40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene. Ribosomes, the organelles that catalyze ... Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S11

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene. Mammalian mitochondrial ... v t e v t e (Genes on human chromosome 2, All stub articles, Human chromosome 2 gene stubs, Protein stubs, Ribosomal proteins) ... Overview of all the structural information available in the PDB for UniProt: Q8TCC3 (Human 39S ribosomal protein L30, ... "Entrez Gene: MRPL30 mitochondrial ribosomal protein L30". Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L30

Page for Ribosomal protein L20 leader at Rfam v t e (GO template errors, Ribosomal protein leader, All stub articles, Molecular ... L20 ribosomal protein leader is a ribosomal protein leader involved in the ribosome biogenesis. It is used as an autoregulatory ... Ribosomal protein leader Meyer MM (March 2018). "rRNA Mimicry in RNA Regulation of Gene Expression". Microbiol Spectr. 6 (2). ... All three types of leader exhibit apparent similarities to the region of Ribosomal RNA to which the L20 protein normally binds ...

https://en.wikipedia.org/wiki/Ribosomal_protein_L20_leader

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene. Mammalian mitochondrial ... v t e v t e (Genes on human chromosome 2, All stub articles, Human chromosome 2 gene stubs, Protein stubs, Ribosomal proteins) ... Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". The Journal of ... Overview of all the structural information available in the PDB for UniProt: O75394 (Human 39S ribosomal protein L33, ...

https://en.wikipedia.org/wiki/Mitochondrial_ribosomal_protein_L33

... is a protein that in humans is encoded by the RPL38 gene. The human RPL38 gene resides on the long ... The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. An ~18kbp deletion, encompassing ... "Entrez Gene: RPL38 ribosomal protein L38". Morgan, WC (1950). "A new tail-short mutation in the mouse whose lethal effects are ... 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379-390. doi: ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L38

RPL27 ribosomal protein L27". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ... 60S ribosomal protein L27 is a protein that in humans is encoded by the RPL27 gene. Ribosomes, the organelles that catalyze ... 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379-90. doi: ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L27

... is a protein that in humans is encoded by the RPL22 gene on Chromosome 1. Ribosomes, the organelles ... The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed ... "Entrez Gene: RPL22 ribosomal protein L22". Wu H, Tian H, Wu G, Langdon G, Kurtis J, Shen B, Ma L, Li X, Gu Y, Hu X, Zhu C (July ... "A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22". Biochemical and Biophysical Research ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L22

The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the ... 40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene. Ribosomes, the organelles that catalyze ... "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal ... "Entrez Gene: RPS3 ribosomal protein S3". Bommer UA, Lutsch G, Stahl J, Bielka H (1992). "Eukaryotic initiation factors eIF-2 ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S3

The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant ... RPS23 ribosomal protein S23". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes ... 40S ribosomal protein S23 is a protein that in humans is encoded by the RPS23 gene. Ribosomes, the organelles that catalyze ...

https://en.wikipedia.org/wiki/40S_ribosomal_protein_S23

RPL18 ribosomal protein L18". Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". ... The protein belongs to the L18E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ... 60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene. Ribosomes, the organelles that catalyze ... 2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379-90. doi: ...

https://en.wikipedia.org/wiki/60S_ribosomal_protein_L18

A diploid isolate of C. blankii had an observed "potential for use in single cell protein production from hemicellulose ... Blood sample DNA sequencing of the 26S ribosomal subunit can definitively identify C. blankii. In nature, Candida blankii forms ...

https://en.wikipedia.org/wiki/Candida_blankii

... the microsporidia shrunk its genome eliminating almost 1000 genes and reduced even the size of protein and protein-coding genes ... "Psyllid endosymbionts exhibit patterns of co-speciation with hosts and destabilizing substitutions in ribosomal RNA". Insect ... Wernegreen, J. J.; Moran, N. A. (1999-01-01). "Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein- ... Distinct roles for mediator proteins in mitosis and meiosis". Proceedings of the National Academy of Sciences. 98 (15): 8411- ...

https://en.wikipedia.org/wiki/Genome_size

Winkelmann DA, Kahan L (Apr 1983). "Immunochemical accessibility of ribosomal protein S4 in the 30 S ribosome. The interaction ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...

https://en.wikipedia.org/wiki/PSMD7

Phylogenetic relationships of Sparassis inferred from nuclear and mitochondrial ribosomal DNA and a protein-coding gene (rpb2 ... Kim (2012). "Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein ...

https://en.wikipedia.org/wiki/Sparassis

... phosphorylates ribosomal protein s6, which is involved in protein synthesis; and phosphorylates a translational repressor ... Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein ... the E7 protein of Human papillomavirus (HPV), and the B18R protein of vaccinia virus. Reducing IFN-α activity may prevent ... the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the ...

https://en.wikipedia.org/wiki/Interferon

Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome ... 2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...

https://en.wikipedia.org/wiki/SKIV2L2

... proteins are of interest for biotechnology and industrial use due to their thermostable nature. One application is ... All-Species Living Tree Project."16S rRNA-based LTP release 132". Silva Comprehensive Ribosomal RNA Database. Retrieved 2015-08 ... Intracellular proteins are not necessarily stable at low pH however, as Sulfolobus species maintain a significant pH gradient ... They are also unique in the sense that the genes encoding the structural proteins of the virus are constantly transcribed and ...

https://en.wikipedia.org/wiki/Sulfolobus

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene. The protein encoded by ... Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with ... Ren Y, Busch RK, Perlaky L, Busch H (1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with ... "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ...

https://en.wikipedia.org/wiki/NOL1

A connector protein dimer (e.g. CTCF or YY1) stabilizes the loop by anchoring one member on the enhancer and the other on the ... 5s ribosomal RNAs and other small RNAs General transcription factor binding sites, e.g. TATA box, B recognition element. Many ... The loop is stabilized by a dimer of a connector protein (e.g. dimer of CTCF or YY1), with one member of the dimer anchored to ... The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are ...

https://en.wikipedia.org/wiki/Promoter_(genetics)

mtDNA is packaged with proteins which appear to be as protective as proteins of the nuclear chromatin. Moreover, mitochondria ... The heavy strand is rich in guanine and encodes 12 subunits of the oxidative phosphorylation system, two ribosomal RNAs (12S ... InterMitoBase: an annotated database and analysis platform of protein-protein interactions for human mitochondria. (apparently ... an annotated database and analysis platform of protein-protein interactions for human mitochondria". BMC Genomics. 12: 335. doi ...

https://en.wikipedia.org/wiki/Mitochondrial_DNA

Peptides and proteins are chains of amino acids held together by peptide bonds (and sometimes by a few isopeptide bonds). ... Some peptides, like alpha-amanitin, are called ribosomal peptides as they are made by ribosomes, but many are nonribosomal ... Conformational protein folding is usually much faster (typically 10-100 ms) than cis-trans isomerization (10-100 s). A ... In the unfolded state of proteins, the peptide groups are free to isomerize and adopt both isomers; however, in the folded ...

https://en.wikipedia.org/wiki/Peptide_bond

Small vacuoles and a Golgi body with stacked cisternae occurred within the cytoplasm outside the ribosomal area. Mitochondria, ... proteins and amino acids. B. dendrobatidis also contains a variety of proteolytic enzymes and esterases that help it digest ... and possess a core area of ribosomes often with membrane-bound spheres of ribosomes within the main ribosomal mass. A small ...

https://en.wikipedia.org/wiki/Batrachochytrium_dendrobatidis

Furthermore, SINEs frequently contain motifs for YY1 polycomb proteins. YY1 is a zinc-finger protein that acts as a ... Short-interspersed nuclear elements are transcribed by RNA polymerase III which is known to transcribe ribosomal RNA and tRNA, ... Thereafter, one of the strands is incorporated into a multi-protein RNA-induced silencing complex (RISC). Among these proteins ... encodes a protein which binds to RNA and acts as a chaperone to facilitate and maintain the LINE protein-RNA complex structure ...

https://en.wikipedia.org/wiki/Short_interspersed_nuclear_element

They hypothesized that RNA could be "druggable" by targeting the 3D structure in the same way as protein 3D structures are used ... Moazed, Danesh; Noller, Harry F. (June 1987). "Interaction of antibiotics with functional sites in 16S ribosomal RNA". Nature. ... Zapp, Maria L; Stern, Seth; Green, Michael R (1993). "Small molecules that selectively block RNA binding of HIV-1 rev protein ... Whereas 85% of the human genome is transcribed into RNA only 3% of the transcripts code for functional protein. Although, ...

https://en.wikipedia.org/wiki/RNA-targeting_small_molecule_drugs

... using a six-gene phylogeny including ribosomal DNA and protein-coding genes, found support for the establishment of a new class ... Early molecular evidence using ribosomal DNA suggested that Geoglossaceae sensu lato was not a monophyletic group, and that the ...

https://en.wikipedia.org/wiki/Geoglossaceae

... "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

https://en.wikipedia.org/wiki/NME3

Mutations in the RPS6KA3 gene can result in expression of an RSK2 protein (ribosomal S6 kinase 2) with reduced or absent kinase ... Mutations in the RPS6KA3 disturb the function of the protein, but it is unclear how a lack of this protein causes the signs and ... The protein RSK2 which is encoded by the RPS6KA3 gene is a kinase which phosphorylates some substrates like CREB and histone H3 ... The protein is involved in cell signaling pathways that are required for learning, the formation of long-term memories, and the ...

https://en.wikipedia.org/wiki/Coffin–Lowry_syndrome

RCSB Protein Data Bank. Databases of proteins: Swiss Institute of Bioinformatics (SIB); European Bioinformatics Institute (EBI ... Turmel M, Gutell RR, Mercier JP, Otis C, Lemieux C (July 1993). "Analysis of the chloroplast large subunit ribosomal RNA gene ... Databases of proteins: Database of protein structures, solved at atomic resolution: "PDB". Research Collaboratory for ... Jacquier A, Dujon B (June 1985). "An intron-encoded protein is active in a gene conversion process that spreads an intron into ...

https://en.wikipedia.org/wiki/List_of_homing_endonuclease_cutting_sites

"Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway". ... Otherwise, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB). Once ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi: ... a type 1 protein-phosphatase-binding protein". The Journal of Biological Chemistry. 276 (17): 14161-9. doi:10.1074/jbc. ...

https://en.wikipedia.org/wiki/P16

The ribosomal protein S19 has been suggested as a possible find me signal. Apoptosis causes a dimerization of S19, inducing a ... "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes". ... dimerized ribosomal protein S19 (RP S19), endothelial monocyte-activating polypeptide II (EMAP II) and formyl peptides ( ... PANX1 is a four pass transmembrane protein that forms large pores in the plasma membrane of a cell, allowing molecules up to 1 ...

https://en.wikipedia.org/wiki/Find-me_signals

... as exclusively present in members of this genus in the proteins 30S ribosomal protein S6-L-glutamate ligase, crossover junction ... endodeoxyribonuclease RuvC, Tim44 domain-containing protein, pyruvate dehydrogenase (acetyl-transferring), homodimeric type, c- ...

https://en.wikipedia.org/wiki/Aquicella

... ribosomal protein L10e, RecJ-like exonuclease, ribosomal protein S15, adenylosuccinate synthase, phosphopyruvate hydratase, RNA ... The number of solutes causes osmotic stress on microbes, which can cause cell lysis, unfolding of proteins and inactivation of ... These studies have also identified 68 conserved signature proteins (CSPs) whose homologs are only found in the members of these ... Because of the elevated potassium levels, haloarchaea have specialized proteins that have a highly negative surface charge to ...

https://en.wikipedia.org/wiki/Haloarchaea

Like many other protein synthesis inhibitors, telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S. ... In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older ... Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit ...

https://en.wikipedia.org/wiki/Telithromycin

ribosomal protein L23a pseudogene 7provided by HGNC. Primary source. HGNC:HGNC:17336 See related. AllianceGenome:HGNC:17336 ... RPL23AP7 ribosomal protein L23a pseudogene 7 [ Homo sapiens (human) ] Gene ID: 118433, updated on 13-May-2022 ... Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. Balasubramanian S, et al. Genome ... Model RNAs and proteins are also reported here.. Reference GRCh38.p14 Primary Assembly. Genomic * NC_000002.12 Reference GRCh38 ...

https://www.ncbi.nlm.nih.gov/gene/118433

Differential stoichiometry among core ribosomal proteins Citation:. Slavov N, Semrau S, Airoldi E, Budnik B, van Oudenaarden A ... While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest ... Differential stoichiometry among core ribosomal proteins. Cell Reports. 2015;1 (13). ... Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation ...

https://scholar.harvard.edu/nslavov/publications/variable-stoichiometry-among-core-ribosomal-proteins

Protein target information for 60S ribosomal protein L7a (zebrafish). Find diseases associated with this biological target and ...

https://pubchem.ncbi.nlm.nih.gov/protein/A0A2R8Q9K6

"Ribosomal Proteins" by people in Harvard Catalyst Profiles by year, and whether "Ribosomal Proteins" was a major or minor topic ... Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway ... Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal ... "Ribosomal Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Ribosomal%20Proteins

More info for Fold d.28: Ribosomal protein S19. Timeline for Fold d.28: Ribosomal protein S19: *Fold d.28: Ribosomal protein ... Lineage for Fold d.28: Ribosomal protein S19. *Root: SCOPe 2.08 *. Class d: Alpha and beta proteins (a+b) [53931] (396 folds). ... Fold d.28: Ribosomal protein S19 [54569] (1 superfamily). alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: ... d.28.1: Ribosomal protein S19 [54570] (1 family) automatically mapped to Pfam PF00203. ...

http://scop.berkeley.edu/sunid=54569

... encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification. ,i,Methods,/i,. A segment of the , ... which cannot be achieved by 16S ribosomal DNA (rDNA) homologue genes comparison. 183 of the 188 (97.3%) clinical isolates ... Ribosomal protein S1 (rpsA), which is in the 30S ribosome subunit, contains the S1 domain that has been found in a large number ... Evaluation of the Ribosomal Protein S1 Gene (rpsA) as a Novel Biomarker for Mycobacterium Species Identification. Hongfei Duan ...

https://www.hindawi.com/journals/bmri/2015/271728/

Recombinant 50S ribosomal protein L4 (rplD). Cat# MBS1000074. Supplier: MyBiosource. Available at Gentaur Genprice in 5 to 7 ... Product Name Synonyme: [50S ribosomal protein L4]. Other Names: [50S ribosomal protein L4P; 50S ribosomal protein L4; 50S ... Recombinant 50S ribosomal protein L4 (rplD) MyBiosource Recombinant Proteins MBS1000074 , Recombinant 50S ribosomal protein L4 ... 50S ribosomal protein L4 (rplD)]Product Name Synonyme: [50S ribosomal protein L4]Other Names: [50S ribosomal... ...

https://biocheminfo.org/mbs1000074-recombinant-50s-ribosomal-protein-l4-rpld/

Incorporation of the yeast mitochondrial ribosomal protein Mrp2 into ribosomal subunits requires the mitochondrially encoded ... Incorporation of the yeast mitochondrial ribosomal protein Mrp2 into ribosomal subunits requires the mitochondrially encoded ... Evidence that synthesis of the Saccharomyces cerevisiae mitochondrially encoded ribosomal protein Var1p may be membrane ... Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA. Herrmann, J.M., Stuart, R ...

https://www.wikigenes.org/e/gene/e/854586.html

... Doctoral dissertation, Harvard ... translation of mRNAs encoding ribosomal proteins and translation factors that comprise 5 terminal oligopyrimidine (TOP) motifs ... mTOR-independent mode for translational regulation of ribosomal proteins and translation factors. ... Modulation of these transcripts consequently impacts ribosome biogenesis and cell-wide protein synthesis capacity. However, it ...

https://dash.harvard.edu/handle/1/41128618

Binding of ribosomal proteins S7, S9, and S19 to unmodified 16S rRNA individually and in all possible combinations showed that ... A paradigm for local conformational control of function in the ribosome: binding of ribosomal protein S19 to Escherichia coli ... binding of either S19 alone or some other protein or combination of proteins to the 16S rRNA can abolish activity of the m5C MT ... A purified complex containing stoichiometric amounts of proteins S7, S9, and S19 bound to 16S rRNA was isolated and shown to ...

https://pubmed.ncbi.nlm.nih.gov/1766869/

60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG) ... and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. The ... 60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG). *PDB DOI: 10.2210/ ... Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins have been shown to be ...

https://www.rcsb.org/structure/4bu2

... rplR) - Gentaur.com - Product info ... Recombinant Rickettsia rickettsii 50S ribosomal protein L18 (rplR)[50S ribosomal protein L18 (rplR)] ... Recombinant Rickettsia rickettsii 50S ribosomal protein L18 (rplR)[50S ribosomal protein L18 (rplR)] ... Ask Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder ...

https://gentaur.com/mybiosource/recombinant-rickettsia-rickettsii-50s-ribosomal-protein-l18-rplr-08025029872

The 60S ribosomal proteins were isolated from ribosomes of human placenta and separated by reversed phase HPLC. The fractions ... For nine proteins (L3, L4, L5, L7A, L10, L14, L19, L31, and L40), the molecular masses could not be determined. Proteins P1 and ... Forty-six large subunit proteins were found, 22 of which showed masses in accordance with the SwissProt database (June 2002) ... A loss of methionine without acetylation was found for protein L8 and L17. ...

https://www.semanticscholar.org/paper/Characterization-and-Analysis-of-Posttranslational-Odintsova-M%C3%BCller/d89b0c7c2730c317a91ede530218c1f9c891a490

A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it ... In the system proposed here, homologous ribosomal proteins are assigned the same name, regardless of species. It is designed so ... The objective is to eliminate the confusion caused by the assignment of identical names to ribosomal proteins from different ...

https://cipsm.de/publications/research-area-c/a-new-system-for-naming-ribosomal-proteins/

Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]. *Ribosomal Protein S6 Kinases, 90-kDa [D08.811.913.696.620.682. ... A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their ... Ribosomal Protein S6 Kinases, 90-kDa*Ribosomal Protein S6 Kinases, 90-kDa ... "Ribosomal Protein S6 Kinases, 90-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was ...

https://profiles.umassmed.edu/display/120533

Lamont, Ella, "The effect of ribosomal protein inhibition on lifespan in Drosophila melanogaster" (2015). WWU Honors College ...

https://cedar.wwu.edu/wwu_honors/530/

ribosomal protein S6 kinase B1 - p70 subfamily. Detailed annotation on the structure, function, physiology, pharmacology and ... 70 kDa ribosomal protein S6 kinase 1 , p70 ribosomal S6 kinase alpha , ribosomal protein S6 kinase beta-1 , ribosomal protein ... ribosomal protein S6 kinase, polypeptide 1 , ribosomal protein S6 kinase ... p70 subfamily: ribosomal protein S6 kinase B1. Last modified on 25/07/2019. Accessed on 09/12/2022. IUPHAR/BPS Guide to ...

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1525

Human Oral Microbiome Database

https://homd.org/genome/blast?gid=SEQF2073

... Version 9.14. Ribosomal proteins identified from 2,087 genomes in 542 taxa. Tree constructed on ...

https://www.homd.org/genome/ribosomal_protein_tree?otid=849

Mitochondrial S1 ribosomal protein genes in legumes: Expression and transfer to the nucleus during evolution. Description. ... This along with the absence of an RNA-binding domain from the mitochondrial S1 ribosomal protein, and the divergence of the 3 ... Mitochondrial S1 ribosomal protein genes in legumes: Expression and transfer to the nucleus during evolution. ... The gene encoding the mitochondrial S1 ribosomal protein (rps1 ) is regarded as being among the most dynamic with respect to ...

https://ruor.uottawa.ca/handle/10393/29902

Mechanisms by which Antibiotics that Bind to Bacterial Ribosomal Subunits Interfere with Translation and Block Protein ... This series of Flash animations shows various mechanisms by which antibiotics that bind to bacterial ribosomal subunits ...

http://teachspatial.org/mechanisms-by-which-antibiotics-that-bind-to-bacterial-ribosomal-subunits-interfere-with-translation-and-block-protein-synthesis/

Boster Bio Anti-Ribosomal Protein S11 RPS11 Antibody catalog # A07622S11. Tested in ELISA, IHC, WB applications. This antibody ... ribosomal protein S11,40S ribosomal protein S11 RPS11 S11 ribosomal protein S11 40S ribosomal protein S11,small ribosomal ... Anti-Ribosomal Protein S11 RPS11 Antibody. RPS11 antibody. Boster Bio Anti-Ribosomal Protein S11 RPS11 Antibody catalog # ... Be the first to review Anti-Ribosomal Protein S11 RPS11 Antibody. *The first user to submit a review for a product is eligible ...

https://www.bosterbio.com/anti-ribosomal-protein-s11-rps11-antibody-a07622s11-boster.html

... be achieved without de novo protein synthesis and ribosomal and extra-ribosomal functions of MPS1 and other ribosomal proteins ... The study of MPS1 and other ribosomal proteins (16) in PCs may shed some light on the functions of these proteins and their ... It is worth noting that Nissl stain strongly labels proteins (5), including ribosomal proteins, and thus some overlapping of ... MPS1 is a ribosomal protein with extra-ribosomal functions such as DNA repair and transcription (16, 19). Berthon et al. ...

https://cgp.iiarjournals.org/content/13/1/47

MD trajectories of the complex between the ribosomal protein S15 and RNA were also recorded in the presence and absence of Mg( ... First, the isolated protein S15 was studied by comparing NMR conformer sets, available in the PDB and recalculated using the ... In the absence of Mg(2+), this network has the same pattern as the network observed in the isolated protein, where the helix ... When the Mg(2+) ions are removed, the internal mobility of the RNA and of the protein increases at the interaction interface ...

https://hal-pasteur.archives-ouvertes.fr/pasteur-01570154

40S ribosomal protein S20: A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. Jb ...

https://swissmodel.expasy.org/templates/6sv4.96

Recombinant Saccharum hybrid 30S ribosomal protein S2, chloroplastic (rps2). Order Recombinant Saccharum hybrid 30S ribosomal ... protein S2 chloroplastic rps2 01015972466 at Gentaur Saccharum hybrid 30S ribosomal protein S2, chloroplastic (rps2) ...

http://chinaelisa.com/catalog/1037-mybiosource/1117-recombinant-saccharum-hybrid-30s-ribosomal-protein-s2-chloroplastic-rps2

Text; Format: print Publication details: Buenos Aires, Argentina : Universidad de Buenos Aires, 1992Dissertation note: Thesis (Ph.D.) - Universidad de Buenos Aires, Argentina, 1992. Availability: Items available for loan: WHO HQ (1)Call number: QX 70 92SC. ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BRibosomal%20proteins.%7D

Human Oral Microbiome Database

https://ehomd.org/genome/blast?gid=SEQF3147

The nucleotide sequence of the ribosomal protein L14 gene of Xenopus laevis.. scientific article published on February 1987 ... Sequences coding for the ribosomal protein L14 in Xenopus laevis and Xenopus tropicalis; homologies in the 5 untranslated ... The nucleotide sequence of the ribosomal protein L14 gene of Xenopus laevis. (English) ...

https://m.wikidata.org/wiki/Q40565434

CROSS-PROTECTIVE EFFECT OF A COMBINED L5 PLUS L3 LEISHMANIA MAJOR RIBOSOMAL PROTEIN BASED VACCINE COMBINED WITH A TH1 ADJUVANT ... Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant ... CONCLUSIONS: The data presented here demonstrate the potential use of L. major L3 and L5 recombinant ribosomal proteins for the ... BACKGROUND: Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against ...

https://www.arca.fiocruz.br/handle/icict/10387

Ribosomal protein S1 ( rpsA ), which is in the 30S ribosome subunit, contains the S1 domain that has been found in a large number of RNA-associated proteins. (hindawi.com)
The ribosomal protein L11 (rpL11), a component of the large 60S subunit, was identified as a PPARα-associated protein. (elsevier.com)
The protein produced from the RPL11 gene is among those found in the large subunit. (medlineplus.gov)
RPL3A is one of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (phytoab.com)
Ribosomal protein S3 (rpS3) is a 243 amino acid component of the 40S ribosomal small subunit. (elsevier.com)
This agent inhibits protein synthesis by binding to the 50S subunit on the ribosome. (medscape.com)
Binds to 30S ribosomal subunit, thus inhibiting bacterial protein synthesis. (medscape.com)
During initiation, the small subunit of the ribosome bound to initiator t-RNA searches for the mRNA starting at the 5' terminal to identify and bind the initiation codon (AUG). The large subunit of the ribosome then joins the small ribosomal subunit to generate the initiation complex at the initiation codon. (bostonmolecules.com)
Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells. (dwarkeshpharma.com)
Mechanism of action :- Spiramycin is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth. (dwarkeshpharma.com)

Evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through short sequence duplications. (harvard.edu)
Gds1 Interacts with NuA4 To Promote H4 Acetylation at Ribosomal Protein Genes. (harvard.edu)
The sequences discrepancy was obvious between M. kansasii and M. gastri, M. chelonae and M. abscessus, M. avium and M. intracellulare , and M. szulgai and M. malmoense , which cannot be achieved by 16S ribosomal DNA (rDNA) homologue genes comparison. (hindawi.com)
Proteomic LC-MS analysis of Arabidopsis cytosolic ribosomes: Identification of ribosomal protein paralogs and re-annotation of the ribosomal protein genes. (semanticscholar.org)
Variation among homologous sequences immediately preceding mitochondrial-located rps1 in legumes was observed, and using a bioinformatics approach, a broad range of sequence conservation (including non-homology) was seen upstream of protein-coding genes located in the seven completely-sequenced flowering plant mitochondrial genomes. (uottawa.ca)
Cmejla R, Cmejlova J, Handrkova H, Petrak J, Petrtylova K, Mihal V, Stary J, Cerna Z, Jabali Y, Pospisilova D. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia. (medlineplus.gov)
Mutations in ribosomal protein genes have for example been found in endometrial cancer (RPL22), T-cell acute lymphoblastic leukemia (RPL10, RPL5 and RPL11), chronic lymphocytic leukemia (RPS15), colorectal cancer (RPS20), and glioma (RPL5). (scilifelab.se)
Among the ribosomal protein genes present in higher plant plastid genomes, rps18 is special in that it is absent from the plastid genomes of several non-green unicellular organisms, including Euglena longa and Toxoplasma gondii. (mpg.de)
Diamond-Blackfan syndrome is caused by the deletion of genes for ribosomal protein RPS19 in 25% of patients, leading to defects in ribosome biogenesis. (medscape.com)
Germ-line mutations in genes encoding components of both the small ( RPS24 , RPS17 , RPS7 , RPS10 , and RPS26 ) and large ( RPL35A , RPL5 , RPL11 , and RPL26 ) ribosomal subunits have also been described in DBA patients. (medscape.com)
genes and of the genes encoding ribosomal proteins L4 and Streptococcus pneumoniae serotype 3, isolated from a L22 were amplified by using the primers and conditions penicillin-allergic patient and initially susceptible to fluoro- previously described (7,8). (cdc.gov)
The Ataxin -family protein ATXN1L has beforehand been reported to work together with CIC in each developmental and illness contexts to facilitate the repression of CIC goal genes and promote the post-translational stability of CIC. (ataxin.com)

Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation in disease. (harvard.edu)
Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells. (harvard.edu)
Modulation of these transcripts consequently impacts ribosome biogenesis and cell-wide protein synthesis capacity. (harvard.edu)
Conclusion: Since MPS1 is involved in cell division, DNA repair, and ribosomal biogenesis, it may be a useful antigen for studying processes such as protein synthesis, oncogenesis, regeneration, aging, and perhaps diseases of the human cerebellum. (iiarjournals.org)
Ribosomes are cellular machines essential for protein synthesis. (scilifelab.se)
Depletion of YbeY and YbeX have largely overlapping phenotypes, including accumulation of 17S pre-rRNA and an approximately 1 kb 16S rRNA cleavage product, sensitivity to heat shock, and to the protein synthesis inhibitors chloramphenicol and erythromycin. (ut.ee)
The mechanism of action of mupirocin is via inhibition of bacterial protein synthesis. (medscape.com)
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, while clavulanate inhibits beta-lactamase producing bacteria. (medscape.com)
Dicloxacillin binds to one or more penicillin-binding proteins, which, in turn, inhibits synthesis of bacterial cell walls. (medscape.com)
Erythromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. (medscape.com)
Third-generation cephalosporin that inhibits bacterial cell wall synthesis by adhering to penicillin-binding proteins. (medscape.com)
Ticarcillin binds to penicillin-binding proteins, thus inhibiting bacterial cell wall synthesis. (medscape.com)
Tetracyclines inhibit protein synthesis and, therefore, bacterial growth by binding with 30S and possibly 50S ribosomal subunits of susceptible bacteria. (medscape.com)
Carbapenems inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins. (medscape.com)
The CCL2 in MAC-T cells attenuates endoplasmic reticulum stress induced by tunicamycin, suggesting that CCL2 regulates intracellular synthesis of proteins and lipids and prevents activation of apoptotic pathways initiated in response to endoplasmic reticulum stress. (ewha.ac.kr)
The information for protein synthesis is generally stored in DNA, which is transcribed to messenger RNA (mRNA), and then translated into a protein. (bostonmolecules.com)
However, in eukaryotes, the processes of transcription and translation are spatially separated and occur sequentially with transcription happening in the nucleus and translation, or protein synthesis, occurring in the cytoplasm. (bostonmolecules.com)
Translation or protein synthesis is a multi-step process that requires a lot of molecules including transfer RNAs (tRNA), amino acids, ATP, GTP and other cofactors to transfer information from mRNA to protein in ribosomes. (bostonmolecules.com)
Although there are some particular differences existed, the overall process of protein synthesis is similar in both prokaryotes and eukaryotes with three stages of initiation, elongation and termination. (bostonmolecules.com)
Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. (dwarkeshpharma.com)
The biochemical processes commonly inhibited include cell wall synthesis in bacteria and fungi, cell membrane synthesis, synthesis of 30S and 50S ribosomal subunits, nucleic acid metabolism, function of topoisomerases, viral proteases, viral integrases, viral envelope entry/fusion proteins, folate synthesis in parasites, and parasitic chemical detoxification processes. (mhmedical.com)

They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits. (harvard.edu)
The findings suggest the importance of phosphorylation of the ribosomal protein uS15 by cytoplasmic protein kinases at several sites for its efficient transfer into the nucleolus, where pre-ribosomal subunits are assembled. (semanticscholar.org)
This series of Flash animations shows various mechanisms by which antibiotics that bind to bacterial ribosomal subunits interfere with translation. (teachspatial.org)
The specific functions of the RPL11 protein and the other ribosomal proteins within these subunits are unclear. (medlineplus.gov)

A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. (umassmed.edu)
Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN. (umassmed.edu)
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetopharmacology.org)
A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetopharmacology.org)
Nishizuka was born in Ashiya City (Hyogo Prefecture, Japan) on July 12, 1932 and was made famous by his discovery of protein kinase C. He will be sadly missed by all who knew him. (nature.com)
This corresponds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1). (cdc.gov)
Aberrations in Capicua (CIC) have lately been implicated as a adverse prognostic consider a mess of most cancers sorts by means of the derepression of targets downstream of the mitogen-activated protein kinase (MAPK) signaling cascade, similar to oncogenic E26 transformation-specific (ETS) transcription components. (ataxin.com)
Though transcriptomic signatures of ATXN1L KO cell traces indicated upregulation of the mitogen-activated protein kinase pathway, ERK exercise was discovered to contribute to CIC operate however not stability. (ataxin.com)

While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition. (harvard.edu)
Together, our findings support the existence of ribosomes with distinct protein composition and physiological function. (harvard.edu)
Proteins found in ribosomes. (harvard.edu)
The 60S ribosomal proteins were isolated from ribosomes of human placenta and separated by reversed phase HPLC. (semanticscholar.org)
Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins. (semanticscholar.org)
obtained impressive results with Archaea on the functions of MPS1 and other ribosomal proteins by genomic context analysis that indicated a previously unrecognized regulatory network coupling DNA replication, DNA repair, DNA transcription, translation and biogenesis of ribosomes that exists in both Archaea and Eukarya ( 16 ). (iiarjournals.org)
The RPL11 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. (medlineplus.gov)
Ribosomes process the cell's genetic instructions to create proteins. (medlineplus.gov)
Some ribosomal proteins are involved in the assembly or stability of ribosomes. (medlineplus.gov)
YbeY is a putative ribosomal endoribonuclease which has been implicated, among other things, to be involved in quality control of 70S ribosomes, in 17S pre-rRNA maturation and in ribosomal degradation. (ut.ee)

RpsA is a vital protein involved in protein translation and the ribosome-sparing process of translation. (hindawi.com)
In silico digestion of all 409 ribosomal protein sequences in Arabidopsis defined the proportion of theoretical gene-specific peptides for each gene family and highlighted the need for low m/z cutoffs of MS ion selection for MS/MS to characterize low molecular weight, highly basic ribosome proteins. (semanticscholar.org)
METTL18 is established as the second human histidine-specific protein MTase, and its functional relevance is demonstrated, indicating that METTL18-mediated methylation of RPL3 is important for optimal ribosome biogenesis and function. (semanticscholar.org)
This along with the absence of an RNA-binding domain from the mitochondrial S1 ribosomal protein, and the divergence of the 3' end of the SSU rRNA from that in bacteria point to the use of a non-classical-bacterial type of ribosome binding in initiator codon recognition. (uottawa.ca)

Because the reaction is not normally associated with members of the YcaO protein family, the Nair Lab is now exploring and predicting other examples of YcaOs that can also cut peptides. (illinois.edu)

We herein describe MPS1 as a new marker of PCs its use in immunohistochemistry in adult human cerebellum, employing specific affinity-purified polyclonal antibodies directed against the N -terminuus synthetic peptide corresponding to amino acids 2 to 17 of MPS1/S27 ribosomal protein with extra-ribosomal functions. (iiarjournals.org)
The DL43 cDNA is 320 nucleotides in length and predicts a protein of 76 amino acids and a calculated molecular mass of 8.9 kiloDaltons. (montclair.edu)
The Drosophila protein shares an 86% identity over the first 22 amino acids with the yeast YL43 protein and a 60% identity over the entire length of the partial sequence available for this protein. (montclair.edu)

Ribosomal Protein S6 Kinases, 90-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in Profiles. (umassmed.edu)
In 1969 he became professor and head of the Department of Biochemistry at Kobe University, where he established an outstanding research group focused on the roles of protein kinases in signal transduction. (nature.com)

60S acidic ribosomal protein P1-B(RPP1B) is a recombinant protein expressed in E. coli. (pp1b.com)

MPS1 is a ribosomal protein with extra-ribosomal functions such as DNA repair and transcription ( 16 , 19 ). (iiarjournals.org)
It has multiple roles in translation and extra-ribosomal functions like apoptosis and DNA repair. (elsevier.com)

When the functions of a protein, as in the case of MPS1/S27, serve a critical and unique survival purpose, the selective pressures of evolutionary laws of nature conserve the DNA sequences encoding such proteins ( 13 - 16 ). (iiarjournals.org)
Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
Protein factors as well as sequences in mRNA are involved in the recognition of the initiation codon and formation of the initiation complex. (bostonmolecules.com)

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. (gentaur.com)
protein_coding" "AAC73596","tesA","Escherichia coli","acyl-CoA thioesterase 1 and protease I and lysophospholipase L1 [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC76562","bcsF","Escherichia coli","DUF2636 family cellulose production small membrane protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC76745","bglF","Escherichia coli","fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component [Ensembl]. (ntu.edu.sg)

Ribosomal Protein LP2 Polyclonal Antibody detects endogenous levels of Ribosomal Protein LP2 protein. (proteogenix.science)
Rabbit Anti S6 Ribosomal Protein (Ab-235) detects endogenous levels of total S6 Ribosomal protein. (genoprice.com)

Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (nih.gov)

2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components and in the hydroxylation of transcription factors and splicing factor proteins. (rcsb.org)
The expression of MPS1/S27 protein in human adult cerebellum has not been established. (iiarjournals.org)
Ribosomal protein L11-mediated inhibition of gene expression is associated with decreased binding to the PPAR-response element (PPRE) DNA sequence. (elsevier.com)
We envisage that changes in expression and the occurrence of ribosomal protein gene mutations play important roles in cancer development. (scilifelab.se)
The subcellular location and expression levels during infection of the ribosomal proteins RPS3a, RPL7, RPL18, RPL18a plus GAPDH were determined. (bvsalud.org)
After the controlled-labeling of proteins during the induction of strobilar development, we identified modifications in protein expression. (cdc.gov)
Protein Expression and Purification. (elsevier.com)
We offer a variety of recombinant protein expression and purification services from gene to protein to crystallography. (bostonmolecules.com)

Synthesized non-phosphopeptide derived from human S6 Ribosomal protein around the phosphorylation site of serine 235 (R-L-S P -S-L). (genoprice.com)

Pharmacological inhibition of this pathway strongly and preferentially suppresses, in a 4EBP1/2-dependent manner, translation of mRNAs encoding ribosomal proteins and translation factors that comprise 5' terminal oligopyrimidine (TOP) motifs. (harvard.edu)
Together, we describe a novel translation assay that is directly applicable to large-scale RNA translation studies, and that enabled us to identify a non-canonical, mTOR-independent mode for translational regulation of ribosomal proteins and translation factors. (harvard.edu)
Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells. (bvsalud.org)
Here we have tested whether the ribosomal protein S18 is required for translation by deleting the rps18 gene from the tobacco plastid genome. (mpg.de)
Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. (expasy.org)
His work during that period included studies on the biosynthesis of nicotinamide adenine dinucleotide (NAD), the involvement of GTP in ribosomal protein translation and ADP-ribosylation by diphtheria toxin. (nature.com)
however, protein translation is also disrupted in eukaryotic mitochondria leading to effects that may confound experimental results. (mdwiki.org)

To evaluate the resolution and reliability of the rpsA gene, encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification. (hindawi.com)
The structures reveal that new protein hydroxylation activities can evolve by changing the coordination position from which the iron-bound substrate-oxidizing species reacts. (rcsb.org)
The objective is to eliminate the confusion caused by the assignment of identical names to ribosomal proteins from different species that are unrelated in structure and function. (cipsm.de)
In the system proposed here, homologous ribosomal proteins are assigned the same name, regardless of species. (cipsm.de)

We describe the nucleotide sequence of a cDNA clone isolated from Drosophila Kc cells which encodes an amino acid sequence homologous to a 60S ribosomal protein from yeast (YL43) and rat (p23). (montclair.edu)
FA is the result of a genetic defect in a cluster of proteins responsible for DNA repair via homologous recombination . (wikipedia.org)

Fox, MG & Gaynor, JJ 1997, ' A cDNA encodes the drosophila homolog of yeast 60S ribosomal protein YL43 ', Mitochondrial DNA , vol. 7, no. 2, pp. 123-125. (montclair.edu)

Many of those protein substrates are equipped within the type of ribonucleoprotein (RNP) complicated consisting of RNA-binding proteins (RBPs) and mRNAs, that are subsequently translated in distal dendritic areas. (ataxin.com)

Since rpL11 is a regulator of p53 and the cell cycle, the association between this protein and PPARα was examined in detail. (elsevier.com)
These studies show that rpL11 inhibits PPARα activity and adds further evidence that ribosomal proteins play roles in the control of transcriptional regulation. (elsevier.com)
The RPL11 gene mutations that cause Diamond-Blackfan anemia are believed to cause problems with ribosomal function. (medlineplus.gov)

Antibodies against these proteins have been used for detection by immunochemistry in analyzing formalin-fixed and paraffin-embedded brain samples from normal and diseased cerebellum. (iiarjournals.org)

Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. (rcsb.org)

Adjustments in the manifestation of transcription elements like Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), Zinc finger proteins SNAIL1 (SNAIL), Twist-related proteins 1 (TWIST) or vimentin (VIM) might become prognostic factors along the way of carcinogenesis [16]. (cancerhugs.com)

An S7-ubiquitin fusion protein (S7-Ub) selectively inhibits MDM2 degradation of p53 and is unaffected by MDMX. (mdc-berlin.de)

Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (medlineplus.gov)
Role of ribosomal protein mutations in tumor development (Review). (scilifelab.se)
Recently, a series of studies applying whole-exome or whole-genome sequencing techniques have led to the discovery of ribosomal protein gene mutations in different cancer types. (scilifelab.se)

Developing biologically active recombinant protein is a challenge to many researchers in both academia and industry. (bostonmolecules.com)

As a result, we found proteins that are involved in important processes during development, such as energy metabolism, control pathways and cellular communication. (cdc.gov)
Because phosphorus is an essential element for DNA, RNA, several ubiquitous cofactors, and phosphorylated proteins, Pi-limitation has major affects on cellular metabolism and physiology. (biomedcentral.com)

RpS3 bound to Concanavalin A, a carbohydrate binding lectin protein, while treatment with peptide-N-glycosidase F shifted the secreted rpS3 to a lower molecular weight band. (elsevier.com)
The proteins responsible for the key molecular events leading to the structural changes between the developmental stages of Echinococcus granulosus remain unknown. (cdc.gov)

Identification of cellular proteins that interact with NS1 may help in further understanding the functions of NS1. (bvsalud.org)
The LC-MS/MS analysis of AHA-labeled NSPs by PSCs undergoing strobilation allowed for the identification of 365 proteins, of which 75 were differentially expressed in comparison between the presence or absence of strobilation stimuli and 51 were expressed exclusively in either condition. (cdc.gov)
IMSEAR at SEARO: Cloning of rice DNA in lambda Charon 4 phage and identification of the gene for a ribosomal protein. (who.int)

It is shown that the intact mass of Rpl1ab is 14 Da larger than its calculated mass with the previously described loss of the initiator methionine residue and N-terminal acetylation, and proposes that the YLR137W gene be given the standard name RKM5 (ribosomal lysine (K) methyltransferase 5). (semanticscholar.org)

Antimicrobial molecules should be viewed as ligands whose receptors are microbial proteins. (mhmedical.com)

NS1 is a multifunctional protein key to viral replication and pathogenesis . (bvsalud.org)

Synthesized peptide derived from the Internal region of human Ribosomal Protein LP2. (proteogenix.science)

In kinetoplasts, maxicircles play an important role in encoding ribosomal RNAs as well as various proteins involved in bioenergetic processes within the mitochondria. (microscopemaster.com)

and (2) The regulation and roles of fucokinase, fucosyltransferases and fucosylated target proteins in signaling networks, tumor progression, metastasis and immune evasion. (moffitt.org)

Interaction cloning was performed using bacterially expressed PPARα to identify proteins involved in PP signaling. (elsevier.com)
In this work, azidohomoalanine (AHA)-specific labeling was used to identify proteins expressed by E . granulosus protoscoleces (PSCs) upon the induction of strobilar development. (cdc.gov)
We used different protein tags that allowed for the visualization and purification of proteins produced specifically after the induction of strobilar development to identify proteins that might be involved in this process (temporally controlled and context-dependent). (cdc.gov)

Regulation of melanoma metastasis by ATF2-mediated control of protein fucosylation. (moffitt.org)
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. (moffitt.org)

also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. (rcsb.org)
Thus, ribosomal/nucleolar stress is likely a key integrating event in DNA damage signaling to p53. (mdc-berlin.de)

Useful in vitro research using ATXN1L human cell traces revealed that lack of ATXN1L results in the buildup of polyubiquitinated CIC protein, selling its degradation by means of the proteasome. (ataxin.com)
Degradation of CIC protein following lack of ATXN1L was as an alternative noticed to be mediated by the E3 ubiquitin ligase TRIM25 which was additional validated utilizing glioma-derived cell traces and the TCGA breast carcinoma and liver hepatocellular carcinoma cohorts. (ataxin.com)

Boster Bio Anti-Ribosomal Protein S11 RPS11 Antibody catalog # A07622S11. (bosterbio.com)

In this paper we isolated a total of 64 proteins from DENV infected human hepatic cells (Huh-7) that interact with NS1 by affinity chromatography and immunoprecipitation assays. (bvsalud.org)

Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis). (medlineplus.gov)

Anatomy12

Organisms7

Diseases1

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes30

Information Science4

Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. (1/4527)

Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae. (2/4527)

Purification and characterization of initiation factor IF-E2 from rabbit reticulocytes. (3/4527)

Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. (4/4527)

Immunological comparison of the proteins of chicken and rat liver ribosomes. (5/4527)

Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (6/4527)

Autoreactive human T cell lines recognizing ribosomal protein L7. (7/4527)

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (8/4527)

Ribosomal Proteins

Ribosomal Protein S6

Ribosomes

Ribosomal Protein S6 Kinases

RNA, Ribosomal

Escherichia coli

Molecular Sequence Data

Base Sequence

Protein Biosynthesis

Amino Acid Sequence

Ribosomal Protein S6 Kinases, 70-kDa

Anemia, Diamond-Blackfan

Saccharomyces cerevisiae

Bacterial Proteins

Ribosome Subunits, Large, Eukaryotic

RNA, Messenger

RNA, Bacterial

Mutation

Polyribosomes

Nucleic Acid Conformation

Ribosome Subunits, Small, Eukaryotic

Geobacillus stearothermophilus

Thermus thermophilus

Cell Nucleolus

Cloning, Molecular

RNA, Ribosomal, 5S

Ribosomal Protein S6 Kinases, 90-kDa

Transcription, Genetic

Genes, Fungal

Sequence Homology, Nucleic Acid

Genes

RNA, Ribosomal, 23S

Operon

Electrophoresis, Polyacrylamide Gel

Sequence Homology, Amino Acid

Poly U

Protein Binding

RNA-Binding Proteins

Ribosome Subunits, Large

Ribosome Subunits, Small, Bacterial

Peptide Elongation Factors

TOR Serine-Threonine Kinases

Sequence Alignment

Binding Sites

Phosphorylation

Protein Kinases

Saccharomyces cerevisiae Proteins

Genes, Bacterial

Escherichia coli Proteins

Chloroplasts

RNA, Fungal

Halobacterium

Emetine

RNA, Ribosomal, 18S

Thiostrepton

Ribosome Subunits, Small

Fungal Proteins

Molecular Weight

Codon

Gene Expression Regulation, Fungal

RNA, Transfer

Models, Molecular

Electrophoresis, Gel, Two-Dimensional

Ribonucleoproteins

Plasmids

Streptomycin

Amino Acids

Restriction Mapping

Peptide Chain Initiation, Translational

Sirolimus

RNA Precursors

Kinetics

Introns

Paromomycin

Species Specificity

Blotting, Northern

RNA Processing, Post-Transcriptional

Ribosome Subunits

Conserved Sequence

Gene Expression Regulation