A state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Neurons which activate MUSCLE CELLS.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Elements of limited time intervals, contributing to particular results or situations.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
The number of males per 100 females.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).
A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The act of BREATHING in.
The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.
The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
A cell line derived from cultured tumor cells.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Established cell cultures that have the potential to propagate indefinitely.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Use of electric potential or currents to elicit biological responses.
These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
A transient absence of spontaneous respiration.
Computer-based representation of physical systems and phenomena such as chemical processes.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Neural tracts connecting one part of the nervous system with another.
A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) or the structures whose movement is directed along cytoskeletal filaments (MYOSIN; KINESIN; and DYNEIN motor families).
The function of opposing or restraining the excitation of neurons or their target excitable cells.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.
Refers to animals in the period of time just after birth.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
The functional hereditary units of INSECTS.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
The relationships of groups of organisms as reflected by their genetic makeup.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.
The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.
Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.
The rate dynamics in chemical or physical systems.
Proteins found in any species of bacterium.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The observable response an animal makes to any situation.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
The quality of surface form or outline of CELLS.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Biological actions and events that support the functions of the RESPIRATORY SYSTEM.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Sexual activities of animals.
The spread of response if stimulation is prolonged. (Campbell's Psychiatric Dictionary, 8th ed.)
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Genotypic differences observed among individuals in a population.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.
The total process by which organisms produce offspring. (Stedman, 25th ed)
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
Transport proteins that carry specific substances in the blood or across cell membranes.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)
Nucleic acid sequences involved in regulating the expression of genes.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.
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Developed by Dr. Jeffrey Carmen, a privately practicing psychologist in New York, passive infrared HEG is a marriage of the ... Coben, R., Linden, M. & Myers, T.E. (2010). Neurofeedback for autism spectrum disorder: a review of the literature. Applied ... In addition, HEG has shown promise at alleviating depression, stress and chronic anxiety.[12] There is also work done by Dr. ... Developed by Dr. Hershel Toomim, near infrared hemoencephalography measures changes in the local oxygenation level of the blood ...
Annual Review of Immunology. 2003, 21: 139-176. ISSN 0732-0582. PMID 12414722. doi:10.1146/annurev.immunol.21.120601.141107.. ... 和HLA-DR (人类T细胞的特异标志)。CTLA-4在活化T细胞表面的上调,对共激活受体有竞争性抑制作用,可以避免活化T细胞的过度活化。活化T细胞的表面糖基化情况也有改变[32]。 ... Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068. doi:10.1146/annurev.immunol.18.1.529.. ... Annual Review of
I wanted to let you know that I saw the page you reviewed, Greg Lemin, and have un-reviewed it again. If you have any questions ... if contests aren't your thing we would be grateful if you could consider destubbing a few African articles during the drive to ... So can you review it then? Jevansen (talk) 04:16, 1 November 2016 (UTC). Orphaned cricketers[edit]. Hi Jevansen ... If you wish to participate in the 2017 election, please review the candidates and submit your choices on the voting page. ...
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"International Socialist Review. 1 (10). Retrieved 27 July 2011.. *^ G. D. H. Cole (2010). Attempts at General Union. Taylor & ... the other the aggressive-expansionist drive to unite all 'labouring men and women' for a 'different order of things'. ... "California Law Review. Archived from the original on 16 December 2017. Retrieved 15 December 2017. ...the United States Supreme ... Social Thought and Action, 1914-1965 (2015). online review. *Mommsen, Wolfgang J., and Hans-Gerhard Husung, eds. The ...
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"Woody Allen Reviews a Graphic Tale of a Scandalous Starlet" by Woody Allen, The New York Times, December 22, 2016 ... Dr. Franklyn Thorpe divorced Astor in April 1935.[2] A legal battle drew press attention to Astor in 1936 when a custody battle ... On loan to Fox Film Corporation, Astor starred in Dressed To Kill (1928), which received good reviews, and the sophisticated ... Dr. Kildare, Burke's Law, and Ben Casey. In 1954, she appeared in the episode "Fearful Hour" of the Gary Merrill NBC series ...
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Dr. Jacques Cohen, an embryologist of the Institute, discovered a technique called the cytoplasmic transfer in 1996 in which ... The New Jersey Attorney General must review the deal before it is official, with the expectation that the merger will be ... In January 2009, Dr. Stuart Geffner performed the world's first all-robotic kidney transplant at Saint Barnabas Medical Center ...
Royalguard11(Talk·Desk·Review Me!) 23:20, 2 December 2006 (UTC) *Unfortunately, this appears to be a story of only Canadian ... Dr. Juan Ignacio Vergara from the Military Hospital emphasized the potentially fatal situation the former president is in. The ... but is this journalistic speculation or is there an article published in a reputable peer-reviewed science journal to back it ...
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Dr. Thiele Polyester Technology. Retrieved 4 January 2019.. *^ "Specifications for Polyester: Poly(ethylene-terephthalate)". ... Scott, Randall W. (1998). "A Practicing Comic-Book Librarian Surveys His Collection and Craft". Serials Review. 24 (1): 49-56. ...
The Republic of China (ROC) was founded by the Kuomintang (KMT) leader Dr. Sun Yat-sen in 1912. The Kuomintang's prior ... China Review. 19 (1): 31-56. ISSN 1680-2012. JSTOR 26603249.. ...
"Clinical Microbiology Reviews (Review). 22 (4): 552-63. doi:10.1128/CMR.00027-09. PMC 2772359. PMID 19822888.. ... "Mystery DR Congo fever kills 100". BBC News Online. 31 August 2007. Archived from the original on 11 November 2007.. ... "Review of Close, William T., Ebola: A Documentary Novel of Its First Explosion. Archived from the original on 21 October 2014. ... "Review of Close, William T., Ebola: Through the Eyes of the People. Archived from the original on 21 October 2014. Retrieved 17 ...
"Dr. Cushing Dead; Brain Surgeon, 70. A Pioneer Who Won Fame as Founder of New School of Neuro-Surgery. Discovered Malady ... Gadelha, Mônica R.; Leonardo Vieira Neto (2014). "Efficacy of medical treatment in Cushing's disease: a systematic review". ...
Basham, A. L.; Dani, D. H. (Winter 1968-1969). "(Review of) A Short History of Pakistan: Book One: Pre-Muslim Period". Pacific ... "Harappa Town Planning"-article by Dr S. Srikanta Sastri. *Art of the Bronze Age: Southeastern Iran, Western Central Asia, and ... said Dr. Richard Meadow of Harvard University, Director of the Harappa Archeological Research Project.[20] This primitive ...
Richards, MP (December 2002). "A brief review of the archaeological evidence for Palaeolithic and Neolithic subsistence". Eur J ...
"The New York Review of Books. Retrieved 30 March 2015.. *^ Roseman, Mark (10 August 2016). "The last word". The Times Literary ... The Development of the Final Solution-lecture from Dr. Havi Dreifuss, Yad Vashem ... Dr. Samuel Drix (Witness to Annihilation), Jochaim Schoenfeld (Holocaust Memoirs), and several survivors of the Janowska ... "Final Solution by David Cesarani review-the Holocaust on the hoof". The Guardian. Retrieved 13 February 2017 ...
"Campaigners call for UK to halt arms exports to Bahrain as Prince Andrew joins sales drive". Campaign Against Arms Trade. 15 ... "Year in Review 2017".. *^ Jackson, Michael (Summer 2007). "Honours of the Crown" (PDF). Canadian Monarchist News. Monarchist ...
The recipients of bursaries are means-tested and reviewed annually, and also carry an obligation to uphold the ideals and ... Dr Helen Wright 2013-2014[15]. *Mr Andrew Powell 2014-present[15] ...
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Official information from NHS about Dr Fatma El-Sayed including contact details, directions, opening hours and service/ ... Dr Fatma El-Sayed. 0151 317 8540 361-365 Queens Drive, Walton , Liverpool, Merseyside, L4 8SJ Website address not added ... Submit your review (required). We only use your email address to communicate with you about your feedback. This includes ...
Al Gore today will not be introduced as Dr. Al Gore, although he was awarded an honorary doctorate of humane letters. Oh, ... So, Karl is "Dr." to NOAA because a) it is good enough for NC State and b) he is quite the scientist in some way that would ... Karl "Dr. Karl". So let me answer about as directly as they did: I notice that you do not "add honorary or honoris causa or ... A review of Walk with Me: An Invitation to Faith, by Neal B. Freeman. ...
Blood Drive by Jeanne C. Stein is on Fayes read shelf. Faye gave this book 3 stars. Shelves: vampires-characters and read-in- ... Blood Drive (Anna Strong Chronicles, #2) by Jeanne C. Stein Fayes review May 17, 2012 ... Flagging a post will send it to the Goodreads Customer Care team for review. We take abuse seriously in our discussion boards. ... Sign into Goodreads to see if any of your friends have read Blood Drive. ...
Damon Albarns opera Dr Dee is a weirdly beautiful and original fantasia that, for sheer imagination, knocks most modern opera ... Damon Albarns Dr Dee, ENO, London Coliseum, review. Damon Albarns opera Dr Dee is a weirdly beautiful and original fantasia ... Striking: Dr Dee performed by English National Opera, Damon Albarn (the Composer), Melanie Pappenheim as Elizabeth Photo: ... It focuses on the figure of Dr John Dee, the Elizabethan alchemist, astronomer, geographer and sage who straddled the realms of ...
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  • 2017 Volkswagen Tiguan Euro-Spec First Drive Review: Baby Q7, Anyone? (motortrend.com)
  • The Marvel comic superhero, Dr. Strange, on which this 2016 film is based, was created by Steve Ditko in 1963, and has odd parallels. (openthemagazine.com)
  • Dr. Kate Zhong, a geriatric psychiatrist and pharmacologist, poses for a photo in her home office in Henderson, Monday, Nov. 28, 2016. (reviewjournal.com)
  • At CES 2016, Mushkin had two USB Flash Drives (UFDs) on display belonging to the 'small footprint' club, the Impact 256GB and the Atom 128GB. (anandtech.com)
  • Many hard drive recovery services use AI and ML, impacting storage devices such as SSDs and flash controllers. (business.com)
  • Our coverage includes reviews of the best recovery for RAID, SSDs and external hard drives. (business.com)
  • Faster read times than rotating hard drives are a given with SSDs, but Intel finally delivered a solid-state drive offering write performance approaching the write times of rotating storage. (extremetech.com)
  • Whereas SSDs typically have a read access of less than 0.200ms, the Black2's flash drive took 15.9ms. (techspot.com)
  • Along with a full range of memory modules for desktops, laptops and servers, Strontium offers an assortment of flash-based data storage products including memory cards, solid state drives (SSDs) and USB flash drives. (cdrlabs.com)
  • With declining PC sales and increase in affordability of SSDs, hard drive vendors have scrambled to make up for the deficit and increase revenue by targeting the NAS market. (anandtech.com)
  • According to Silicon-Power the drive meets military drop-test standard (MIL-STD-810F 516.5 Procedure IV. (geardiary.com)
  • If I ever need another procedure, Dr. D would be my first an d only choice. (wellness.com)
  • I went to Dr. Danilyants for a second opinion after researching the Dual Port innovative procedure to remove large fibroids. (wellness.com)
  • I feel I was totally prepared for this surgery, first going to listen to Dr. Baranov's seminar, where he made it very easy to understand this entire procedure. (obesityhelp.com)
  • I highly recommend if your thinking about having this procedure go to Dr Barnov info session. (obesityhelp.com)
  • In our 4 TB NAS drive roundup from last year, we also indicated that efforts would be taken to add more drives to the mix along with an updated benchmarking scheme involving RAID-5 volumes. (anandtech.com)
  • Due to HGST's strange sampling scheme, we are still trying to obtain enough drives for our NAS-specific benchmkaring, but they did send us their 4 TB SAS drive for participation in this roundup. (anandtech.com)
  • For evaluation in a NAS environment, we configured three drives of each model in a RAID-5 volume and processed selected benchmarks from our standard NAS review methodology. (anandtech.com)
  • Durable, easy to use and among the top choices for gassy babies, the Dr. Brown's Natural Flow Options Glass Wide-Neck Bottle features an internal venting system that works to reduce colic , gas and spit-up, and the vented nipple allows baby to control the pace of her own feeding. (todaysparent.com)
  • Dr. Brown's nipples come in five flow rates, ranging from newborn to nine months plus. (todaysparent.com)
  • One of our testers even found that her baby spit up less during and after feeding when using the Dr. Brown's Natural Flow Options Glass Wide-Neck Bottle. (todaysparent.com)
  • The Dr. Brown's glass bottle suffered no breakage, cracking or scratches, and the bottle's travel lid stayed on four out of five times. (todaysparent.com)
  • The Dr. Brown's Natural Flow Options Glass Wide-Neck Bottle has six separate pieces (a couple more than many bottles), so it requires a little extra TLC when it comes to cleaning . (todaysparent.com)
  • In our lab tests, we found that the Dr. Brown's Natural Flow Options Glass Wide-Neck Bottle didn't leak at all when carried around in a diaper bag for 30 minutes. (todaysparent.com)
  • Dr. Brown's HappyPaci Silicone Pacifier is easy to clean, BPA Free, and affordable. (gadgetreview.com)
  • Dr Brown's HappyPaci Soft Silicone Pacifier is shaped like a bottle nipple to provide your little one with a familiar sucking apparatus and its one piece construction eliminates the possibility of a choking hazard. (gadgetreview.com)
  • With Dr. Brown's HappyPaci Pacifier, soothing an infant is simple because it is a pacifier shaped like Dr Brown's bottle nipple. (gadgetreview.com)
  • The Dr. Brown's HappyPaci Pacifier is also dishwasher and sterilizer safe. (gadgetreview.com)
  • The Dr. Brown's HappyPaci Silicone Pacifier is made easy because of the familiar Dr Brown's nipple shape baby has become accustomed to. (gadgetreview.com)
  • While there may be a slight chance of nipple confusion and size issues, Dr. Brown's HappyPaci Silicone Pacifier has everything you could want in a pacifier. (gadgetreview.com)
  • Sign into Goodreads to see if any of your friends have read Blood Drive . (goodreads.com)
  • Click here for the Fat Loss Factor website or HERE to read the full review. (prweb.com)
  • You can also claim loyalty rewards, make bookings or enquiries, track and attend our latest events of interest, send us a photo for treatment recommendations, read and leave reviews. (cnet.com)
  • Samsung claims the drive 'sets the standard for speed, capacity, durability and connectivity' - read our review to find out whether our experts agree. (which.co.uk)
  • Keep in mind that even while the Plextor drive sports higher read times, better access rates, and a better burst speed, it's also significantly more expensive that the ASUS offering. (hothardware.com)
  • The same sectors are read again and compared to the sectors written to the hard drive. (hothardware.com)
  • Nevertheless, the one chapter on "Telomerase Does Not Cause Cancer" is controversial and so, not only did I provide references, I provided a link so readers could read the full text scientific peer reviewed studies. (youtube.com)
  • The sequential read performance is much the same with the full drive dropping just 4% of its original performance when empty. (techspot.com)
  • Although, I had read good reviews, Dr. Danilyants exceeded my expectations! (wellness.com)
  • The inside story on Dr. Gary M. Levin's remarkable Multiple Sclerosis Cure "Read on to discover what really causes your multiple sclerosis! (purrl.net)
  • Producers Marc Platt and Adam Siegel optioned the source novel after Siegel read a review from Publishers Weekly. (wikipedia.org)
  • The top one, the no-compromise DV mode, only works with the hard drive - it's been included primarily for editing footage from a digital camcorder. (techradar.com)
  • In a feat of miniturization Toshiba has today revealed it is working on the worlds first sub 1 inch Hard Disk Drive. (dpreview.com)
  • Tokyo -- Toshiba Corporation today announced development of 0.85-inch hard disk drive (HDD), the first hard drive to deliver multi-gigabyte data storage to a sub-one-inch form factor. (dpreview.com)
  • With hackers, viruses and malware running rampant, the rising number of cyberattacks is urging many businesses to turn to hard drive recovery services. (business.com)
  • Hard drive nightmares like lost email conversations and exposed financial data can halt productivity and hinder your business's growth. (business.com)
  • The ability to recover lost data from mobile devices, flash drives and RAID servers is a great benefit to look for when choosing a hard drive recovery service. (business.com)
  • After researching many hard drive recovery services, we've found the ones we think are best for various business needs. (business.com)
  • While some hard drive recovery services have already started investing in artificial intelligence (AI) and machine learning (ML), we expect more companies to join them in the year ahead. (business.com)
  • With features such as automatic backups, updates and malware scans, AI and ML are influencing hard drive recovery trends and enhancing reliability. (business.com)
  • To support these AI and ML capabilities, hard drive recovery services must be able to work well with parallel file systems and flash-native tools, including NAND flash memory chips. (business.com)
  • Below are all our reviews for hard drive recovery services. (business.com)
  • How Does a Hard Drive Work? (business.com)
  • At the center of this process is the hard drive that stores a system's data. (business.com)
  • Despite becoming more rugged and reliable over the 50 years since its invention, the hard drive can be the weak link in the chain of saving and recalling company data. (business.com)
  • The size of a paperback book, traditional hard drives are electro-mechanical marvels that hold terabytes of data. (business.com)
  • While they may be more expensive than traditional hard drives, the popularity of flash storage or solid-state devices (SSD) can help with reliability. (business.com)
  • Adding a shelf to the back of your Mac to store hard drives and other knick-knacks may have seemed like a no-brainer, but the BackPack was the accessory that nailed it. (thenextweb.com)
  • The Samsung Portable SSD T3 is a small external hard drive. (which.co.uk)
  • Hard disk drives have been one of the main sources of noise in computers for years. (silentpcreview.com)
  • some of the first articles in SPCR nearly eight years ago introduced DIY approaches to hard drive silencing, essential in those days because most desktop drives were a lot noisier than they are today. (silentpcreview.com)
  • Hard Drive Silencing: Sandwiches & Suspensions ) Still, hard drives continue to make noise today, and those who want truly silent computers seek to eliminate this noise. (silentpcreview.com)
  • The Scythe Quiet Drive 2.5 is basically a double-box enclosure with damping between the boxes to reduce the airborne noise and mechanical vibration of any 2.5″ hard drive. (silentpcreview.com)
  • Scythe Quiet Drive 2.5 retail package and a notebook hard drive of the type it is meant to silence. (silentpcreview.com)
  • The Quiet Drive has the same dimensions as a standard 3.5″ desktop hard drive so that it can be installed in a 3.5″ internal drive bay. (silentpcreview.com)
  • Prosoft Engineering 's Data Rescue Center can keep a dead hard drive from ruining a business's prospects, with the ability to repair it and recover what it holds. (business.com)
  • As a full-service data recovery firm, Prosoft works with everything you might need to recover data from, including laptop hard drives, tablets, phones, flash drives and even RAID arrays. (business.com)
  • In order to determine how well each drive extracts audio tracks, sectors are copied to the hard drive from three different locations on the CD. (hothardware.com)
  • With three kids at home I've got thousands and thousands of memories, in the form of digital pictures, stored on various hard drives. (geardiary.com)
  • From time to time I take one of the portable hard drives with me, to a family members house, or on the road. (geardiary.com)
  • The Silicon-Power Armor A80 is a portable USB 3.0 Hard Drive ready to take on life's unexpected surprises. (geardiary.com)
  • The Armor A80 is the perfect hard drive for those people who take their data on the road often. (geardiary.com)
  • If you want to insure your data survives whatever life throws at you the Armor A80 is the type of external hard drive you want. (geardiary.com)
  • I received the 64GB version, which is the perfect size for storing photos, documents, and other items I don't want cluttering my main hard-drive, especially when those items are things that I might still need access to on a regular basis. (geardiary.com)
  • Many photographers have bought notebooks and subnotebooks so that they can easily transfer shots from the memory cards to their hard drives. (ixbtlabs.com)
  • What they need is a hard drive, batteries and a memory slot. (ixbtlabs.com)
  • They developed a device called photo hard drive. (ixbtlabs.com)
  • Photos can be recorded not only on a hard drive, but directly on CDs in the field conditions. (ixbtlabs.com)
  • And not every lab would receive a photo hard drive. (ixbtlabs.com)
  • Well, even the most compact CD-RW drive is much bigger than a 2.5' hard drive, plus other components. (ixbtlabs.com)
  • Fortunately, there are two buttons for recording the cards' contents onto CDs while inexpensive photo hard drives are usually deprived of the check mode at all, and it's not always possible to make 2-3 copies if a hard drive doesn't have a large size. (ixbtlabs.com)
  • It was "Dr. Son" calling "Dr. Dad," an achievement that had been so very long and hard in coming. (bookbrowse.com)
  • Back in July 2012 , Western Digital began the trend of hard drive manufacturers bringing out dedicated units for the burgeoning SOHO / consumer NAS market with the 3.5' Red hard drive lineup. (anandtech.com)
  • Later, Seagate also jumped into the fray with a hard drive series carrying similar firmware features. (anandtech.com)
  • On the enterprise side, hard drive vendors have been supplying different models for different applications, but all of them are quite suitable for 24x7 NAS usage. (anandtech.com)
  • The correct choice of hard drives for a NAS system is influenced by a number of factors. (anandtech.com)
  • In this review, we will discuss some of these aspects while evaluating ten different hard drives targeting the NAS market. (anandtech.com)
  • Get full reviews, ratings, and advice delivered weekly to your inbox. (commonsensemedia.org)
  • Patient satisfaction ratings and reviews are based on personal opinions. (healthgrades.com)
  • Want to see more ratings and reviews from real customers? (angieslist.com)
  • However, the Black2's sequential write performance is extremely poor, hitting just 139MB/s -- mighty close to the 140MB/s delivered by its own disk drive. (techspot.com)
  • Dr. Seuss lends his formidable talents to the Land of Nod, sending young sleepers off with a chuckle in their hearts. (commonsensemedia.org)
  • Leave it to Dr. Seuss to make high comedy out of sleeping. (commonsensemedia.org)
  • A dazzling beginning reader by Dr. Seuss. (commonsensemedia.org)
  • Is Dr. Seuss rolling in his grave yet? (rottentomatoes.com)
  • The Cat in the Hat isn't so much a movie as an extremely long commercial for Universal's Dr. Seuss-inspired products and tie-ins. (rottentomatoes.com)
  • Whereas the Plextor PX-708A maintains a uniform rotational velocity and access pattern, both ASUS drives perform erratically here. (hothardware.com)
  • It doesn't break records, but in general it looks good (my Plextor drive has 12/10/32 and I'm not going to replace it ever). (ixbtlabs.com)
  • The simple plug and play drives comes in three different storage capacities, 320G, 500G or 640G. (geardiary.com)
  • Built from the same technology that made the Intel SSD 335 Series possible, the Intel Solid State Drive 525 Series packages a LSI/SandForce SF-2281VB1-SDC processor optimized for the mSATA interface with 6Gb/s bandwidth and available in capacities up to 240GB utilizing 25nm INFT NAND Flash components. (madshrimps.be)
  • Dr. Keller promotes the concept of one patient focus per day to provide the one on one care that his patients deserve. (regrowhair.com)
  • One of the latest additions to Strontium's line of USB flash drives is the AUTO. (cdrlabs.com)
  • Flash drives are a dime a dozen these days, and most of them carry uninteresting specifications. (anandtech.com)
  • In particular, flash drives advertising smaller physical footprints have tended to carry disappointing performance numbers. (anandtech.com)
  • External memory is my best option, so I've been trying the Leef Copper Edition Surge 64GB USB Flash Drive . (geardiary.com)
  • We have reviewed the Atom 64GB version before. (anandtech.com)
  • I highly recommend giving Google Drive a chance if you own a Google account and find yourself constantly emailing files back and forth from device to device. (spiceworks.com)
  • Geography Drive USA is a title that I can easily recommend as an application that is both highly educational and a lot of fun. (148apps.com)
  • I wholeheartedly recommend Dr. Natalya Danilyants. (wellness.com)
  • I would highly recommend Dr. Baranov if your looking for help losing weight. (obesityhelp.com)
  • In the same PC, we also evaluate the performance of the drive using some aspects of our direct attached storage (DAS) testing methodology . (anandtech.com)
  • Work on the drive has centered on Toshiba's Ome Operations-Digital Media Network, home to the company's main development site for digital and mobile products and the manufacturing site for the device. (dpreview.com)
  • Prosoft can even work with ransomware-inundated or encrypted drives as long as you have the encryption key. (business.com)
  • A team at the University of California, San Diego, has just shown an evolution-warping technology called a gene a drive can work in mice. (technologyreview.com)
  • That means a mouse gene drive probably can't work in the wild-at least not yet-because it's not efficient enough. (technologyreview.com)
  • When traditional and unconventional medicine does not work it may be time to try something else, something that is tried by thousands of people all over the world and reviewed back as a definite cure for tinnitus. (continuumbooks.com)
  • Identifying and working with these key elements are at the heart of Dr. Phillip C. McGraw's latest work, Self Matters, and soon they will be at the heart of your own new work: you. (bookbrowse.com)
  • In this groundbreaking work, Dr. Phil challenges you to find your "authentic self" -- that person you once were before life took its toll. (bookbrowse.com)
  • Dr. Baranov does amazing work. (obesityhelp.com)
  • I first saw the bad review about Dr. Labored and was hesitant to make an appointment but the receptionist was so helpful and it was so easy to make an appointment. (healthgrades.com)
  • Was this review helpful? (germandeli.com)
  • While mission-critical applications tend to use SAS drives, it is the nearline SATA versions that are more suitable for home / SMB users. (anandtech.com)
  • Other than the HGST SAS drive, the other nine drives all carry a SATA interface. (anandtech.com)
  • As usual, we will start off with a feature set comparison of the various drives, followed by a look at the raw performance when connected directly to a SATA 6 Gbps port. (anandtech.com)
  • In this article, Benchmark Reviews tests the Intel SSD 525 Series mSATA Solid State Drive (SSDMCEAC240B301) against SATA 6GB/s storage solutions. (madshrimps.be)
  • So, Karl is "Dr." to NOAA because a) it is good enough for NC State and b) he is quite the scientist in some way that would qualify for a degree if he tried. (nationalreview.com)
  • That said, the company attempts to keep its prices low, which is good news for small businesses with broken drives. (business.com)
  • The Deca Drive makes the most of decent electronics with a well-designed lens that throws out plenty of peripheral light, with the central beam focused a good 10m in front of you. (bikeradar.com)
  • Dr. Strange' has a few things that many other comic book adaptation movies don't - irony, self deprecating humor and good actors in Cumberbatch and Mikkelsen who can speak the funny lines in the script, with a perfectly straight, superhero and/or villainous face. (openthemagazine.com)
  • Bettman stopped short of saying that Las Vegas will definitely get an NHL club, but wished Foley and Las Vegas good luck in the ticket deposit drive. (reviewjournal.com)
  • As I have already written, NOAA styles the co-lead author of the looming " Unified Synthesis Product " as "Dr. Tom Karl", though NOAA's own various bios published for Mr. Karl list his highest academic achievement as a master's degree (though he was awarded an honorary doctorate of humane letters by North Carolina State in 2002). (nationalreview.com)
  • FatLossReviews.net releases an insightful and informative product review. (prweb.com)
  • As well as thousands of impartial product reviews from our Test Labs, a Which? (which.co.uk)
  • This product has no reviews. (skinstore.com)
  • It is normally really worth taking a look at some freely available stats on this product, and I do so in the statistics part of the review. (purrl.net)
  • They don't have an effect on the neutrality of the product reviews as we incorporate them for each and every product. (purrl.net)
  • Yet, thankfully, I do not have to depend solely on me to create these product reviews - I have you guys to assist me! (purrl.net)
  • Dr Gary's Multiple Sclerosis Cure has a frenzy ranking of 61.79/100 that is definitely a typical score and shows that even though the product is selling well, it's not quite reached the top of the sales ladder. (purrl.net)
  • I have been wanting to get to the 3 week point before posting up a review of my observations of this product. (anabolicminds.com)
  • Dr. Baranov came HIGHLY recommended by SEVERAL people and I started to realize there was a common theme to everything I had heard about him and the practice at Saratoga Hospital--professionalism, caring, experience. (obesityhelp.com)
  • A gene drive involves adding a "selfish" gene to animals that is then passed to their offspring at a rate higher than the usual 50-50 chance. (technologyreview.com)
  • There's a plan to kill off malaria mosquitoes , for example, and one conservation group wants to use a gene drive to eradicate invasive mice and rats on islands , where they prey on sea birds. (technologyreview.com)
  • Gene drive systems function by being inherited at higher rates compared with other alleles, allowing them to rapidly spread throughout a population. (nature.com)
  • RNA-guided CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) nucleases may ease the creation of multiple types of gene drive systems with improved effectiveness. (nature.com)
  • Gene drive systems (or gene drives) possess the potential to provide revolutionary solutions to key public health and environmental issues 1 , 2 . (nature.com)
  • Scientists think they can use gene drives to wipe out wild populations of animals with genes that are bad for them. (technologyreview.com)
  • Gene drives can be used to spread desirable genes throughout wild populations or to suppress harmful species. (nature.com)
  • Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne diseases such as malaria. (nature.com)
  • Here, we discuss the different types of engineered gene drives and their potential applications, as well as current policies regarding the safety and regulation of gene drives for the manipulation of wild populations. (nature.com)
  • Dr. Avram is a wonderful dermatologist. (zocdoc.com)
  • With this benchmark, we loaded a 698MB CD-R full of .mp3 files in the drive and let CD-DVD Speed run through its cycle of tests. (hothardware.com)
  • The CT 200h uses a highly modified existing platform incorporating numerous, exclusively developed body, chassis and powertrain control system engineering applications designed to offer a choice of two distinct driving moods - Dynamic, or Relaxing - in conjunction with the full hybrid's EV, ECO, NORMAL and SPORT, 'on-demand' drive modes. (theautochannel.com)
  • The RevoDrive 350 only suffers a 5% performance loss in our single large file copy test once the drive is full dropping from 629MB/s to 598MB/s. (techspot.com)
  • Full Review (794 words). (bookbrowse.com)
  • Dr. Baranov may or may not have had the goal to improve, change and impact so many people's lives and heath but go to one support group meeting (yes, they are open to anyone interested, pre or post-op) and there will be a ballroom full of people who all have stories about how amazing this man is. (obesityhelp.com)
  • Toshiba expects to start sampling the new drive in summer 2004 and to start mass production in autumn 2004, at an initial monthly production capacity of two to three hundred thousand units. (dpreview.com)
  • With the new drive, only a quarter the size of a 1.8-inch drive, Toshiba achieves a smaller, lighter, high capacity storage medium in which low power consumption is complemented by high performance. (dpreview.com)
  • The drive will have an initial capacity of 2 to 4 GB, and deliver enhanced data storage to smaller, lighter more efficient products. (dpreview.com)
  • The drive under development is planned to have a capacity of 2 to 4GB, but Toshiba anticipates achievement of even higher densities in the near future. (dpreview.com)
  • As solid-state drive technology evolves, we expect products to improve in three key axes: performance, price, and capacity. (extremetech.com)
  • Can it make a 7200rpm notebook drive quiet enough to take on an SSD, at least acoustically and in storage capacity? (silentpcreview.com)
  • The WD Red Pro is meant for rackmount units up to 16 bays, but is not intended to be a replacement for drives such as the WD Re, Seagate Constellation ES.3, Seagate Enterprise Capacity v4 and the Toshiba MG03ACA400 which target enterprise applications requiring durability under heavy workloads. (anandtech.com)
  • We put in the warranty request and were told by DR that they had them come out last time as a courtesy and this is not covered so whenever we walk in 3 rooms upstairs the floor makes noise. (consumeraffairs.com)
  • Dr. Maria Bazzini, DO does not participate in Zocdoc to offer online booking at this time. (zocdoc.com)
  • Both ASUS drives perform similarly for the third time. (hothardware.com)
  • They were conducted in September 2015 and Dr. Andrews believes gene therapy prices will not come down any time soon. (youtube.com)
  • This review is available to non-members for a limited time. (bookbrowse.com)
  • It is about a brilliant neurosurgeon called Dr. Stephen Strange, who is in a car accident and loses the use of his gifted hands, once capable of pinpoint precision in surgery. (openthemagazine.com)
  • A brilliant scholar, Dr. Perricone completed medical school in just 2 1/2 years, graduating at the head of his class. (alibris.com)
  • Dr. Richard Keller completed his General Surgery training at University of Illinois and has been a practicing physician for over 20 years. (regrowhair.com)
  • Dr. Jeffrey Crecelius, MD is a neurosurgery specialist in Lafayette, IN and has been practicing for 39 years. (healthgrades.com)
  • Dr. Mario Flores, MD is an internal medicine specialist in Pittsfield, MA and has been practicing for 27 years. (healthgrades.com)
  • All our students transitioned to Chromebooks last year, and have been using drive for years. (spiceworks.com)
  • I have been with Dr. Robert Martino for years, I am very happy with him and I have referred several of my friends to him. (angieslist.com)
  • Pros who have not received a review in the last three years do not have a rating displayed. (angieslist.com)
  • Dr. Howard Austrager has been clinic director of MetroWest Spine Clinic for the past 14 years. (angieslist.com)
  • Dr. Capasso researched for years and jotted down the outcomes of his research in this book. (continuumbooks.com)
  • Dr. James Phillips and Alan Watson, the program's founders have experienced the same condition and have suffered for years and tried numerous medicine but to no avail. (continuumbooks.com)
  • I also decided to stop Suboxone (stupid, stupid me for trying opiates) after a years use of Rx opiates and I knew that motivation and drive would be an issue. (anabolicminds.com)
  • Dr. Richard Keller has the skills and experience to deliver outstanding hair transplant results. (regrowhair.com)
  • the Wyndham Orlando Resort International Drive provides a true Florida resort experience. (expedia.com)
  • Prosoft's Data Rescue Center has the staff, equipment and experience to squeeze every bit of data from a worn-out server drive or dead notebook. (business.com)
  • I don't usually write reviews, but wanted to share my experience. (wellness.com)
  • This can prove to be a death sentence to your files if the drive is continually written and rewritten, as in a file server. (business.com)
  • Do not believe any of the positive reviews written here and especially those at ratemds.com. (ripoffreport.com)
  • The '4-Day Thyroid Fix' is a book that is written by Dr. Anthony Capasso. (continuumbooks.com)
  • All tracks are written by Dr. John, except where indicated. (wikipedia.org)
  • I will make sure to warn people from this litter in every website I have bought this from, or wherever I can write a review about it. (thriftyfun.com)
  • Write a review and tell users why it's Green! (judysbook.com)
  • Movies and TV shows are Certified Fresh with a steady Tomatometer of 75% or higher after a set amount of reviews (80 for wide-release movies, 40 for limited-release movies, 20 for TV shows), including 5 reviews from Top Critics. (rottentomatoes.com)
  • Several critics listed Drive as one of the best films of 2011, including the National Board of Review. (wikipedia.org)
  • View our latest car news , new car reviews or used car reviews online. (drive.com.au)
  • Mulligan is always a treat to view in film, and her presence in Drive is reason alone to see this movie in my mind. (geeksofdoom.com)
  • Dr. Seuss's Sleep Book can help youngsters to sleep or crank them into a frenzy of laughter and queries, depending on the kid. (commonsensemedia.org)
  • Dr. Richard Keller specializes in follicular unit strip surgery (FUSS) and recently started offering advanced follicular unit extraction (FUE) at his clinic. (regrowhair.com)
  • The Sonata Hybrid incorporates Hyundai's latest Hybrid Blue Drive system. (popularmechanics.com)
  • The drive incorporates a compact notebook-type CD-RW from Matsushita with the speeds of 24/10/24. (ixbtlabs.com)
  • The rugged design is great, but only is protective when the drive is powered off. (apple.com)
  • Overall a great drive. (apple.com)
  • Drive is a great way to store files and an even better way to share them. (spiceworks.com)
  • Solid state drives are great silent alternatives, but for large storage needs, they remain cost-prohibitive, while the cost-per-GB of HDDs continues to plummet. (silentpcreview.com)
  • This line certainly gets great reviews. (essentialdayspa.com)
  • Dr. Andrews commented on this video shortly after I uploaded it: Great Review Brent! (youtube.com)
  • Dr. Rowland herself was also friendly and had a great bedside manner, but after glancing at my X-Rays, she confirmed that I had a cavity in one of my molars. (judysbook.com)
  • Judy's Book has millions of listings and reviews for the best and not so great. (judysbook.com)
  • I was referred to Dr. Danilyants by my primary physician - she is absolutely great. (wellness.com)
  • Now, Dr. Phil takes those lessons a great leap further and explores one of the most challenging questions facing us all: When you look in the mirror, who is truly hiding beneath that face? (bookbrowse.com)
  • By using the high performance thermal conductive sheet, the Quiet Drive gives a high cooling efficiency. (silentpcreview.com)
  • The 4K-64 thread write performance of WD's flash drive was relatively poor at 109.6MB/s, 42% slower than the 840 Evo. (techspot.com)
  • Based on the number of tracks and the spacing of the dips, it seems logical that both ASUS drives might have been slowing down at the beginning of each track, quickly recovering to resume prior performance. (hothardware.com)
  • This one is for the sport exhaust, this one selects the drive modes - Comfort, Auto and Dynamic - and the button with the checkered flag cycles between three 'Performance' modes - Dry, Wet and Snow. (autotrader.ca)
  • What we are looking for is a reduction in write performance caused by the drive having to clear blocks before storing new data. (techspot.com)
  • Located in Dallgow-Doeberitz, a quite town 5 km west of Berlin, Germany, WGE Dr Brues is defined by outstanding performance and accessible handling. (pharmaceutical-business-review.com)
  • So I was a bit surprised by the defensive justification when NOAA finally got back to me on my request for clarification of what academic background supports the "Dr." title they assign to a man they only claim has earned a Master's degree, but who also claims a Ph.D. from NCSU in 1978, in an actual CV posted by John's Hopkins University. (nationalreview.com)
  • And often they review only the products that provide the most kickbacks when you buy. (gadgetreview.com)