A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Narrowing of the spinal canal.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures.
The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.
A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
Procedure in which an anesthetic is injected directly into the spinal cord.
The paired bands of yellow elastic tissue that connect adjoining laminae of the vertebrae. With the laminae, it forms the posterior wall of the spinal canal and helps hold the body erect.
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Neurons which activate MUSCLE CELLS.
Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.
The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.
Forward displacement of a superior vertebral body over the vertebral body below.
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
The spinal or vertebral column.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Surgery performed on the nervous system or its parts.
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Space between the dura mater and the walls of the vertebral canal.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
Injuries involving the vertebral column.
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Act of eliciting a response from a person or organism through physical contact.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.
Devices which are used in the treatment of orthopedic injuries and diseases.
Any operation on the spinal cord. (Stedman, 26th ed)
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
A bundle of NERVE FIBERS connecting each posterior horn of the spinal cord to the opposite side of the THALAMUS, carrying information about pain, temperature, and touch. It is one of two major routes by which afferent spinal NERVE FIBERS carrying sensations of somaesthesis are transmitted to the THALAMUS.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
The joint that occurs between facets of the interior and superior articular processes of adjacent VERTEBRAE.
Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.
Elements of limited time intervals, contributing to particular results or situations.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Broken bones in the vertebral column.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Use of electric potential or currents to elicit biological responses.
Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Amount of stimulation required before the sensation of pain is experienced.
Vestibular nucleus lying immediately superior to the inferior vestibular nucleus and composed of large multipolar nerve cells. Its upper end becomes continuous with the superior vestibular nucleus.
Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.
A benign neoplasm composed of a mixture of adipose tissue and blood vessels. (Dorland, 27th ed)
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Refers to animals in the period of time just after birth.
Deformities of the SPINE characterized by abnormal bending or flexure in the vertebral column. They may be bending forward (KYPHOSIS), backward (LORDOSIS), or sideway (SCOLIOSIS).
Internal devices used in osteosynthesis to hold the position of the fracture in proper alignment. By applying the principles of biomedical engineering, the surgeon uses metal plates, nails, rods, etc., for the correction of skeletal defects.
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.
A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.
A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).
The largest of three bones that make up each half of the pelvic girdle.
Injuries to the PERIPHERAL NERVES.
Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
A reflex in which the AFFERENT NEURONS synapse directly on the EFFERENT NEURONS, without any INTERCALATED NEURONS. (Lockard, Desk Reference for Neuroscience, 2nd ed.)
A disorder characterized by the accumulation of encapsulated or unencapsulated tumor-like fatty tissue resembling LIPOMA.
A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.
Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Specialized devices used in ORTHOPEDIC SURGERY to repair bone fractures.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Renewal or physiological repair of damaged nerve tissue.
Surgical interruption of a spinal or cranial nerve root. (From Dorland, 28th ed)
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock.
Excision, in part or whole, of an INTERVERTEBRAL DISC. The most common indication is disk displacement or herniation. In addition to standard surgical removal, it can be performed by percutaneous diskectomy (DISKECTOMY, PERCUTANEOUS) or by laparoscopic diskectomy, the former being the more common.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The position or attitude of the body.
A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)
The physical activity of a human or an animal as a behavioral phenomenon.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
The grafting of bone from a donor site to a recipient site.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The observable response an animal makes to any situation.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
Neural tracts connecting one part of the nervous system with another.
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.
A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Pain during the period after surgery.
Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Adjustment and manipulation of the vertebral column.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
The function of opposing or restraining the excitation of neurons or their target excitable cells.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The act of constricting.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Surgical insertion of a prosthesis.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Application of a ligature to tie a vessel or strangulate a part.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).
The most common inhibitory neurotransmitter in the central nervous system.
A dead body, usually a human body.
Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Subdural hematoma of the SPINAL CANAL.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.
Comparison of the BLOOD PRESSURE between the BRACHIAL ARTERY and the POSTERIOR TIBIAL ARTERY. It is a predictor of PERIPHERAL ARTERIAL DISEASE.
The inferior part of the lower extremity between the KNEE and the ANKLE.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Contractile tissue that produces movement in animals.
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
A sample of CSF can be taken via lumbar puncture. This can reveal the intracranial pressure, as well as indicate diseases ... spinal cord, and stretches below the end of the spinal cord to the sacrum.[1][2] There is a connection from the subarachnoid ... CSF pressure, as measured by lumbar puncture, is 10-18 cmH2O (8-15 mmHg or 1.1-2 kPa) with the patient lying on the side and 20 ... Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord. It is produced by specialised ...
Analysis of the patient's cerebrospinal fluid (CSF), which is collected by a lumbar puncture ("spinal tap"), reveals an ... The extent of spinal paralysis depends on the region of the cord affected, which may be cervical, thoracic, or lumbar. The ... In cases of spinal polio, if the affected nerve cells are completely destroyed, paralysis will be permanent; cells that are not ... When spinal neurons die, Wallerian degeneration takes place, leading to weakness of those muscles formerly innervated by the ...
Lumbar spinal stenosis Spondylosis Spinal disease Lumbar disc disease Claudication Orthopedic surgery Neurosurgery Deer T, ... Abnormal signs may be revealed if the patient is observed walking until they exhibit NC. For example, a positive "stoop test" ... such as lumbar spinal stenosis (LSS) or other degenerative spinal diseases. Decreased walking and lower body motor ability due ... As a result of LSS, the spinal canal in the lumbar spine narrows, causing damage and arthritic changes in the spine. These ...
A lumbar puncture (also known as a spinal tap) can determine whether the spinal column and brain have been invaded. Brain and ... Immunohistochemical testing may reveal TdT or CALLA antigens on the surface of leukemic cells. TdT is a protein expressed early ... spinal column involvement can be diagnosed either through confirmation of leukemic cells in the lumbar puncture or through ... Cancer spreading into the Central nervous system (brain or spinal cord) has worse outcomes. ...
The majority of spinal disc herniations occur in the lumbar spine (95% at L4-L5 or L5-S1). The second most common site is the ... of the spinal canal following injection of a contrast material into the surrounding cerebrospinal fluid spaces will reveal ... "History of Lumbar Endoscopic Spinal Surgery and the Intradiskal Therapies". Advanced Concepts in Lumbar Degenerative Disk ... Spinal disc herniation is known in Latin as prolapsus disci intervertebralis. Click images to see larger versions Lumbar disc ...
A CT scan or MRI scan may reveal enlargement of one or both lateral ventricles, or causative masses or lesions, and lumbar ... CSF is present within the subarachnoid space, which covers the brain, spinal cord, and stretches below the end of the spinal ... A sample of CSF can be taken via lumbar puncture. This can reveal the intracranial pressure, as well as indicate diseases ... A lumbar puncture that drains CSF may also be used as part of treatment for some conditions, including idiopathic intracranial ...
Bhumibol suffered from lumbar spinal stenosis, and received a microsurgical decompression for the condition in July 2006. He ... WikiLeaks cables reveal scandal and disease in Thai royal family The Australian, 24 June 2011 "Household Bureau: The King ... In 2011, it was revealed as part of WikiLeaks's leak of United States diplomatic cables that he had suffered from Parkinson's ... "Doctors to perform surgery to cure lumbar spine stenosis for His Majesty". The Nation. Archived from the original on 29 ...
While the first lumbar punctures were performed in the late 19th century, the tests revealing elevated lymphocyte levels within ... "Cerebral spinal fluid (CSF) collection". www.nlm.nih.gov. National Institute of Health. Retrieved 2015-04-19. Gómez-Aranda, F; ... While a lumbar puncture may return a WBC count within the normal range of 0-5 cells per µL, this does not rule out the ... Modern lumbar punctures testing for lymphocyte counts are commonly used to diagnose or rule out certain diseases such as ...
It is intended as a means of breaking up adhesions (scar tissue) of or about spinal joints (cervical, thoracic, lumbar, sacral ... whose pre-MUA advanced diagnostic imaging revealed fibrosis after prior lumbar surgery.[unreliable medical source?] A 2005 ... Also, in the presence of a positive lumbar EMG study (nerve root compression) with lumbar disc herniation, Level II evidence ... Kohlbeck FJ, Haldeman S. Medication-assisted spinal manipulation. Spine J. 2002;2(4):288-302. DiGiorgi D. Spinal manipulation ...
Both these segments are located within the first thoracic vertebra to the first or second lumbar vertebra as the spinal cord ... An in-depth study of the lateral grey columns in the thoracic region of rats revealed two types of cells. One cell type was ... Each of these roots is the end of a spinal nerve connecting the spinal cord to the body. The vertebral column is divided into ... The lumbar splanchnic nerves from the upper two lumbar segments synapse in the abdomen on the inferior mesenteric ganglia, ...
... sacs most frequently located in the spinal canal of the S1-to-S5 region of the spinal cord (much less often in the cervical, ... Histologic examination reveals the Tarlov-cyst outer wall is composed of vascular connective tissue, and the inner wall is ... Occasionally, these cysts are observed in the lumbar and thoracic spine. However, these cysts most commonly arise at the S2 or ... Tarlov cysts are most commonly located in the S1 to S4/S5 region of the spinal canal, but can be found along any region of the ...
A lumbar puncture (also known as a spinal tap) can determine whether the spinal column and brain have been invaded. Brain and ... Immunohistochemical testing may reveal TdT or CALLA antigens on the surface of leukemic cells. TdT is a protein expressed early ... spinal column involvement can be diagnosed either through confirmation of leukemic cells in the lumbar puncture or through ... brain or spinal cord) has worse outcomes. Morphological, immunological, and genetic subtypes Person's response to initial ...
This may be evaluated with an MRI of the brain with gadolinium based contrast and lumbar spinal tap with testing of the ... Definitive diagnosis is achieved by biopsying the involved tissue, which will reveal lymphoproliferative neoplasia. Most ... cerebral spinal fluid for EBV viral levels. The presence of respiratory symptoms, such as cough or shortness of breath, in the ...
... that the networks responsible for locomotion are distributed throughout the lower thoracic and lumbar regions of the spinal ... Bellardita C, Kiehn O (June 2015). "Phenotypic characterization of speed-associated gait changes in mice reveals modular ... Whelan PJ (December 2003). "Developmental aspects of spinal locomotor function: insights from using the in vitro mouse spinal ... has also been shown to partially reactivate spinal locomotor neurons in complete or motor-complete spinal cord-injured patients ...
If the prolapse is very large and presses on the spinal cord or the cauda equina in the lumbar region, affection of both sides ... By revealing displacement of the contrast material, it can show the presence of structures that can cause pressure on the ... Pengherniaan cakera lumbar[sunting , sunting sumber]. Lumbar disc herniations occur in the lower back, most often between the ... MRI Scan of lumbar disc herniation between fourth and fifth lumbar vertebral bodies. ...
It generally targets the lumbar region of the spinal cord, and the only true way of diagnosing it is through biopsy or needle ... Less than 15% of K. kingae-positive clinical specimens reveal organisms on Gram stain. Infections due to K. kingae are ...
There is also a notable incidence of lumbar spinal fusion patients that present with sacroiliac pain and hypermobility, ... Diagnostic testing, such as X-ray, CT scan, or MRI, do not usually reveal abnormalities; therefore, they cannot reliably be ... A fixation of the joint (screws or similar hardware only, without the use of bone grafting) is more common than a spinal fusion ... Yoo H, Shin D, Song C (2015). "Changes in the spinal curvature, degree of pain, balance ability, and gait ability according to ...
... where other diagnostic tests have failed to reveal clear confirmation of a suspected disc as the source of pain, and surgical ... a CT scan identifies leakage from the discs to identify any spinal disc herniation. Possible complications include nerve damage ... Lumbar provocative discography (also referred to as "discography" or discogram) is an invasive diagnostic procedure for ...
In 1946 and 1955 the neurosurgeon Eduard Busch performed a lumbar sympathectomy on Blixen's spinal cord, but her pain returned ... In 2012, the Nobel records were opened after 50 years and it was revealed that Blixen was among a shortlist of authors ... "prejudices reveal more about the perceiver than the perceived". The book consists of four tales: "Shadows on the Grass", which ... in spite of the fact that blood and spinal fluid tests were negative. By the time she left Africa, Blixen was suffering from ...
T-ALL can spread to areas of the brain and spinal cord, which can be diagnosed through lumbar puncture assessment in patients ... This also reveals the spread of T-ALL. Genetic testing helps identify chromosomal abnormalities in the patients. This can help ... Lumbar puncture helps to identify leukemic cells surrounding the cerebrospinal fluid (CSF). Even if leukemic cells are not ... To prevent ineffective treatments towards T-Cells that have invaded the CNS, lumbar puncture allows doctors to determine ...
... and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. As an adjuvant ... Richter R (2011-06-28). "Medtronic's spinal fusion product shown to be harmful in bold review by medical journal and its ... reveal a further need "to modify the available carrier systems as well as explore other biomaterials with desired properties." ... Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA (May 2009). "Six-year outcomes of anterior lumbar interbody ...
Even though a CT scan can reveal these pertinent signs of lumbar spinal stenosis, it can sometimes give a cloudy image due to ... A common disorder that causes increased pressure in the spinal canal is lumbar spinal stenosis. Lumbar spinal stenosis is ... The most common lumbar spinal fusion occurs between L4 and L5. A lumbar spinal fusion may be recommended when non-surgical ... Spinal microsurgery is a minimally invasive unilateral laminotomy used to correct bilateral lumbar spinal compression. Spinal ...
Lumbar puncture (spinal tap), this helps determine via a test using the cerebral-spinal fluid, obtained from the lumbar region ... MRI imaging reveals T2 hyperintensity in the structures of the medial temporal lobes, and in some cases, other limbic ... Neurological examinations usually reveal a drowsy or confused person. Stiff neck, due to the irritation of the meninges ... Encephalitis with meningitis is known as meningoencephalitis, while encephalitis with involvement of the spinal cord is known ...
Where the spinal cord ends in some of the lumbar vertebrae, a fine fiber issues downwards, and the canal runs up even within ... revealing the resplendent inner world of the divine forces and consciousness of the soul and spirit. Yoga refers to this power ... Suppose you add eight after eight, piled one on top of the other, that will represent the spinal cord. The left is the Ida, the ... We know that the spinal cord is composed in a peculiar manner. If we take the figure eight horizontally (∞), there are two ...
2005). "The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding". Dev. ... 2009). "A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar ... can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models. It is also being investigated for its ... "Delivery of recombinant follistatin lessens disease severity in a mouse model of Spinal Muscular Atrophy". Hum. Mol. Genet. 18 ...
... which is collected by a lumbar puncture ("spinal tap"), reveals an increased number of white blood cells (primarily lymphocytes ... The extent of spinal paralysis depends on the region of the cord affected, which may be cervical, thoracic, or lumbar.[42] The ... A blockage of the lumbar anterior spinal cord artery due to polio (PV3) ... Spinal polio, the most common form of paralytic poliomyelitis, results from viral invasion of the motor neurons of the anterior ...
The extra lumbar and thoracic vertebrae account for the cat's spinal mobility and flexibility. Attached to the spine are 13 ... Nie, W.; Wang, J.; O'Brien, P.C. (2002). "The genome phylogeny of domestic cat, red panda and five Mustelid species revealed by ... An analysis of the domestic cat genome revealed that the ancestral wildcat genome was significantly altered in the process of ... seven lumbar vertebrae (humans have five); three sacral vertebrae (as do most mammals, but humans have five); and a variable ...
Neurological examination may reveal a stiff neck in occasional cases (erroneously suggesting meningitis). Anaerobic and ... Macewan W (1893). Pyogenic Infective Diseases of the Brain and Spinal Cord. Glasgow: James Maclehose and Sons. Ingraham FD, ... Lumbar puncture procedure, which is performed in many infectious disorders of the central nervous system is contraindicated in ...
It may also cause intermittent double vision.[30][33] Lyme radiculopathy is an inflammation of spinal nerve roots that often ... revealed the presence of the DNA sequence of Borrelia burgdorferi making him the earliest known human with Lyme disease.[242] ... Demonstration by lumbar puncture and CSF analysis of pleocytosis and intrathecal antibody production are required for definite ... Further examination revealed spirochetes in 60% of the ticks. Burgdorfer credited his familiarity with the European literature ...
"Response of lumbar paraspinal muscles spindles is greater to spinal manipulative loading compared with slower loading under ... "X-rays can reveal neither the subluxations nor the innate intelligence associated with chiropractic philosophy, because they do ... Spinal manipulation, which chiropractors call "spinal adjustment" or "chiropractic adjustment", is the most common treatment ... spinal manipulation was ineffective at treating any condition.[9] Spinal manipulation may be cost-effective for sub-acute or ...
Usually the hip (head of the femur), lower back (lumbar spine), or heel (calcaneum) are imaged, and the bone density (amount of ... The ability to work in two planes is important for orthopedic and spinal surgery and can reduce operating times by eliminating ... Ionising and non-ionising radiation can be used to reveal the internal structure of the body on an image receptor by ...
Further research reveals that another possible consequence of wearing high heels is an increase of pressure in one's veins. ... This changed position places more pressure and tension on the lower lumbar spine which explains why the women complained of ... Spinal Column Curvature. In a 2016 study from the Sahmyook University in Korea, researchers wanted to investigate the effects ... The results of the study indicated an increase in both cervical and lumbar muscle activation as heel height increased. The ...
... innervated by sympathetic nervous system fibers from the lumbar spinal cord and parasympathetic fibers from the sacral spinal ... and Conundrums Revealed. Sterling Publishing Company, Inc. ISBN 978-1-4027-5039-7. Retrieved 17 October 2013.. ... Spinal cord injury. During spinal shock, the bladder is flaccid and unresponsive. It becomes overfilled, and urine dribbles ... The bladder can be made to contract by voluntary facilitation of the spinal voiding reflex when it contains only a few ...
... and lumbar. Definite ALS was defined as upper motor neuron (UMN) and lower motor neuron (LMN) signs in three spinal cord ... While a magnetic resonance imaging (MRI) is often normal in people with early stage ALS, it can reveal evidence of other ... Classic ALS accounts for about 70% of all cases of ALS and can be subdivided into spinal-onset and bulbar-onset ALS.[11] Spinal ... spinal muscular atrophy, and spinal and bulbar muscular atrophy can also mimic certain aspects of the disease and should be ...
Bone scans should reveal osteoblastic appearance due to increased bone density in the areas of bone metastasis-opposite to what ... Spinal cord compression can occur with metastases to the spine and can be treated with steroids, surgery, or radiation therapy ... "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the lumbar region and in ... Prostate cancer in the spine can also compress the spinal cord, causing tingling, leg weakness and urinary and fecal ...
Dandy also observed that air introduced into the subarachnoid space via lumbar spinal puncture could enter the cerebral ... Consequently, fMRI can be used to reveal brain structures and processes associated with perception, thought and action. The ...
Blood tests to reveal microfilaremia are useful in many, but not all cases, as one third of loiasis patients are ... Microfilariae have been recovered from spinal fluids, urine, and sputum. During the day they are found in peripheral blood, but ... Within 12-24 hours post-Ivermectin treatment (D1), individuals complained of fatigue, anorexia, and headache, joint and lumbar ...
Later study revealed they were generated by rapid fluttering of the eyelids, sometimes so minute that it was difficult to see. ... Spinal cord and spinal canal. *Spinal decompression. *Discectomy. *Intervertebral disc annuloplasty. *Cordotomy ... It has been shown that combining or multiplying such measures can reveal previously hidden information in EEG data.[145] ... "Burns & Rajan (2015) Combining complexity measures of EEG data: multiplying measures reveal previously hidden information. ...
A systematic review found moderate quality evidence that spinal manipulation is effective for the treatment of acute lumbar ... Needle EMG is the more sensitive portion of the test, and may reveal active denervation in the distribution of the involved ... Only low level evidence was found to support spinal manipulation for the treatment of chronic lumbar radiculopathies, and no ... "Epidural Injections for Lumbar Radiculopathy and Spinal Stenosis: A Comparative Systematic Review and Meta-Analysis". Pain ...
Neck, lumbar and pelvic vertebrae are very reduced in number (only 2-10 lumbar and pelvic vertebrae are present), while only a ... "Giant boid snake from the paleocene neotropics reveals hotter past equatorial temperatures". Nature. 457 (7230): 715-718. ... Spinal osteoarthropathy (reptile disease). *The New Encyclopedia of Snakes. *The Snakes of Europe and Snakes of Europe ... lumbar (lower back), sacral (pelvic), and caudal (tail) vertebrae. Early in snake evolution, the Hox gene expression in the ...
Similarly, spinal or lumbar puncture (e.g. spinal injections, epidurals, etc.) carry increased risk so treatment is suspended ... and neither did stratification of the duration of anticoagulation reveal a trend towards fracture.[41] ... and the spinal cord.[19] Risk of bleeding is increased if the INR is out of range (due to accidental or deliberate overdose or ...
Neurosurgery of the spine covers the cervical, thoracic and lumbar spine. Some indications for spine surgery include spinal ... Harvey Cushing at Johns Hopkins Hospital revealed greater care being taken in neurosurgery. During this time, surgeons did not ... Spondylosis is the condition of spinal disc degeneration and arthritis that may compress the spinal canal. This condition can ... If there is prior permanent neural tissue damage spinal surgery may not take away the symptoms.[citation needed] ...
While this may explicitly relate only to lumbar scolioses, small imbalances in the lumbar spine could precipitate thoracic ... "Scoliosis and Spinal Disorders. 13: 3. doi:10.1186/s13013-017-0145-8. PMC 5795289. PMID 29435499.. ... Recent longitudinal studies reveal that the most common form of the condition, late-onset idiopathic scoliosis, causes little ... "Scoliosis and Spinal Disorders. 11: 20. doi:10.1186/s13013-016-0076-9. PMC 4973373. PMID 27525315.. ...
The sacro-lumbar expansion is not unique to stegosaurs, nor even sauropods. It is also present in birds. In their case, it ... Based on the results of the study, it was revealed that Stegosaurus had a bite similar in strength to that of modern ... Soon after describing Stegosaurus, Marsh noted a large canal in the hip region of the spinal cord, which could have ... Buchholz (née Giffin) EB (1990). "Gross Spinal Anatomy and Limb Use in Living and Fossil Reptiles". Paleobiology. 16 (4): 448- ...
In the third stage, neurological examination may reveal clonus and positive Babinski sign. Coma and seizures represent the most ... Spinal cord. *Myelitis: Poliomyelitis. *Demyelinating disease *Transverse myelitis. *Tropical spastic paraparesis. *Epidural ...
a) T1-weighted and (b) short tau inversion recovery (STIR) magnetic resonance images of lumbar and lower thoracic spine in ... Involvement of the spinal joints is more suggestive of psoriatic arthritis than rheumatoid arthritis.[3] Osteoarthritis shares ... at the enthesis and reveal bone erosion at tendon insertion (short thin arrows). ...
When the sacral sections of the spinal cord were studied in patients with Shy-Drager syndrome, it was revealed that cell death ... The sacral region of the spinal cord is fourth segment (cervical, thoracic, and lumbar being the first three) of vertebrae in ... The sacral region of the spinal cord is fourth segment (cervical, thoracic, and lumbar being the first three) of vertebrae in ... The sympathetic innervation (nerve supply) comes from the sympathetic preganglionic neurons located in the upper lumbar spinal ...
Spinal curvatures of kyphoscoliosis or lumbar lordosis may be present. The pelvic bones may be deformed. A condition known as ... "Evidence in the bones reveals rickets in Roman times". the Guardian. Retrieved 20 August 2018 ...
... in lumbar spinal cord increases following a sciatic nerve constriction injury". Brain Research. 565 (1): 1-7. doi:10.1016/0006- ... The blue material shows DNA visualized with DAPI stain, and reveals the nuclei of the astrocyte and other cells. Image courtesy ... They may occur in many parts of the brain and sometimes in the spinal cord. They can occur at any age and they primarily occur ... "Transplantation of Specific Human Astrocytes Promotes Functional Recovery after spinal Cord Injury". PLoS ONE. 6 (3): e17328. ...
An X-ray may reveal this. Pleural effusion, in which there is fluid abnormally present between the two pleurae of the lungs, is ... The thoracic spinal levels at which the three major structures pass through the diaphragm can be remembered by the number of ... descend and insert into the lumbar vertebrae at L1 & L2.[5][6] ... which serves to strengthen the lumbar spine.[10] The key to ... the phrenic nerve that innervates the diaphragm originates from the cervical spinal cord (C3,4, and 5). As the septum ...
... (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord ... have revealed at least twelve other genes outside the HLA locus that modestly increase the probability of MS.[38] ... Testing of cerebrospinal fluid obtained from a lumbar puncture can provide evidence of chronic inflammation in the central ... These lesions most commonly affect the white matter in the optic nerve, brain stem, basal ganglia, and spinal cord, or white ...
Lumbar puncture or surgical treatment may be required to prevent optic atrophy in cases of intracranial hypertension refractory ... However, one study has revealed a possible connection to food allergies, particularly to dairy products.[40] An estimated ... Less commonly there may be inflammation of the brain or spinal cord, blood clots, aneurysms, or blindness.[2][1] Often the ...
CT scan of the lumbar spine prior to surgery reveals undiagnosed osteoporosis in many patients For patients contemplating ... FDA approves first spinal tether device to treat children with idiopathic scoliosis The U.S. Food and Drug Administration today ... Robotic technology for spinal fusion at Norwalk Hospital helps great grandmother stay active Lifelong Norwalk, Connecticut ... Global task force of bone health experts question effectiveness of spinal fusion procedures There is little to no evidence that ...
To our knowledge, there is no report of osteolipomas in the lumbar spine. ,i,Case Presentation.,/i, We report a very rare case ... of a solitary lumbar intraspinal osteolipoma, presenting as a cauda equina syndrome. The intraspinal osteolipoma was excised en ... Plain radiographs fail to reveal the lesion. MRI would demonstrate a mass occupying the spinal canal. A clarity of thought is ... reported a case of a lumbar spinal ossifying lipoma in the subcutaneous region in communication with an intradural lipoma ...
Shown are transverse sections through lumbar spinal cord. Lateral is to the right. Approximate margin of the spinal cord is ... a, In the lumbar spinal cord at 11.5 dpc, many En-1-expressing cells (green) are detected lateral (arrow) and medial (arrowhead ... 1982) Motoneuron cell death in the developing lumbar spinal cord of the mouse. Dev Brain Res 4:473-479. ... Expression Patterns of Developmental Control Genes in Normal andEngrailed-1 Mutant Mouse Spinal Cord Reveal Early Diversity in ...
Less invasive approach to lumbar fusion - Mayo Clinic. The orientation of the screws away from the neural elements potentially ... Examining the implications of astrocyte heterogeneity across the brain and spinal cord - Mayo Clinic. Staining for F-actin ... using rhodamine-conjugated phalloidin reveals dynamic cytoskeletal elements.. *. Pulmonary Medicine Clinical Trials - Medical ...
Histopathology revealed the presence of typical (World Health Organisation grade I) meningiomas. The mean Ki-67/MIB-1 index was ... A case of a lumbar meningioma was recorded. The most common presenting symptom was motor and sensory deficits and unsteady gait ... Gezen F, Kahraman S, Canakci Z (2000) Review of 36 cases of spinal cord meningioma. Spine 25:727-731CrossRefPubMedGoogle ... Levy W, Bay J, Dohn D (1982) Spinal cord meningioma. J Neurosurg 57:804-812CrossRefPubMedGoogle Scholar ...
A lumbar puncture revealed multiple oligoclonal bands in the cerebral spinal fluid. MRI has demonstrated numerous plaques in ...
A lumbar puncture revealed multiple oligoclonal bands in the cerebral spinal fluid. Clinical history: MRI has demonstrated ...
... revealing fibrillation potentials, denervation, and increased amplitude. However, nerve conducti... more ... Spinal muscle atrophy. By age 9 years, this patient with type I spinal muscle atrophy now has thoracic curve of 60° and lumbar ... Spinal muscle atrophy. Follow-up radiographs in patient at age 13 years reveal some spinal decompensation. Note so-called ... Spinal muscle atrophy. Spine anteroposterior view. Spinal curvature is progressing. Lumbar curve now is 70°, and thoracic curve ...
Spinal muscle atrophy. By age 9 years, this patient with type I spinal muscle atrophy now has thoracic curve of 60° and lumbar ... Spinal muscle atrophy. Follow-up radiographs in patient at age 13 years reveal some spinal decompensation. Note so-called ... Spinal muscle atrophy. Spine anteroposterior view. Spinal curvature is progressing. Lumbar curve now is 70°, and thoracic curve ... Spinal muscle atrophy. At age 4 years, this boys chest radiograph already reveals presence of significant 32° left thoracic ...
Lumbar puncture, or spinal tap: This can diagnose meningitis.. In a lumbar puncture, cerebrospinal fluid from around the brain ... Blood test: This may reveal higher-than-normal levels of antibodies to WNV. A complete blood count may be done. ... Myelitis, or West Nile poliomyelitis: Inflammation of the spinal cord. *Acute flaccid paralysis: Sudden weakness in the arms, ... CT or MRI scan of the head: This can sometimes reveal brain inflammation and swelling. ...
Lumbar puncture to assess for CNS involvement. Cerebral spinal fluid may show pleocytosis with a predominance of lymphocytes ... After initial infection, IFAT reveals the earliest positive results for IgM antibodies; also confirmed early-on by the DA ... In patients with advanced esophageal involvement, chest radiography may reveal a tubular mass along the aorta and air-fluid ... 45] In the acute setting, echocardiography may reveal pleural effusions, apical or anterior dyskinesis, and left ventricular ...
A lumbar puncture revealed a CSF pleocytosis (Table). He was admitted with a diagnosis of postviral demyelination syndrome and ... MRI of the spine revealed mild cervical spinal stenosis and homogeneous enhancement of the cauda equina consistent with ... involvement of spinal motor neurons and lesions in the ventral gray matter of the spinal cord, with an absence of lesions in ... Spinal Cord 2001;39:662--3.. *Solomon T, Kneen R, Dung N, et al. Poliomyelitis-like illness due to Japanese encephalitis virus ...
The MR images revealed a CSF leak from the lumbar thecal sac. A computed tomography (CT) myelogram, performed by injection into ... After shunt reservoir manometry indicated low pressure, spinal magnetic resonance (MR) imaging was performed. ... Our study revealed that saccadic reading is slower in PD, but controls and PD patients are both impacted by visuospatial ... Examination revealed a 1-2 Hz down-beating nystagmus in primary gaze that worsened with left, right, and down gazes. Gaze ...
Spinal mobility in the cervical and lumbar spine correlates with magnetic resonance imaging findings for inflammatory and ... Contrast-enhanced computed tomography scan revealed bilateral sacroiliitis. Magnetic resonance imaging of the spinal cord ... and lumbar (lumbar flexion [LF], lateral-lumbar-flexion [LLF]) spine component scores (linear definition). Generalised linear ... Spinal mobility in the cervical and lumbar spine correlates with magnetic resonance imaging findings for inflammatory and ...
A section through the lumbar spinal cord shows β-gal positive neurons (blue, arrows) only in the ventrolateral motor columns. ( ... Motoneurons from E14 spinal cord of NF-L-Cre; Stat3flox/wt and NF-L-Cre; Stat3flox/KO mice were cultivated in the presence of ... Spinal motoneurons do not depend on Stat3 signaling during the phase of naturally occurring cell death. (A) Embryonic ... A) RT-PCR analysis using total RNA derived from acutely isolated facial nuclei revealed an increase of Bcl-xl mRNA 2 d after ...
Lumbar puncture showed increased monocyte count and cerebrospinal fluid pressure. Culture of the spinal fluid revealed no ... 1). Head computed tomography (CT) scan revealed a thick skull, heterogeneous diploe, and a lot of hardened macular shadow. No ... Skull radiography revealed hypertransradiancy with multiple round marginal irregular osteoclasia. Computed tomography (CT) scan ... Magnetic resonance imaging (MRI) scans revealed diploe and thick skull with outer table erosion appearing as "worm-eaten" spots ...
Repeated lumbar puncture revealed increased cerebro-spinal fluid (CSF) pressure and protein content. Malignant cells were not ... Surgical treatment consisted in (1) placement of an ommaya reservoir for daily CSF puncture, (2) Spinal dural biopsy confirming ... MRI now ruled out local tumor progression but revealed meningeal contrast enhancement along the medulla, the myelon, and the ... Repeated lumbar puncture revealed increased cerebro-spinal fluid (CSF) pressure and protein content. Malignant cells were not ...
Studies revealed Schistosoma mansoni involvement of the upper lumbar spinal cord. Histological examination of the involved ... The present report is the third biopsy-proven case of S. mansoni of the spinal cord in continental United States. ... A review of the pertinent literature indicates that biopsy-proven schistosomiasis of the spinal cord is rare. ... portion of cord suggested the presence of an ectopic female adult worm in an adjacent spinal vein may have been responsible. ...
Studies revealed Schistosoma mansoni involvement of the upper lumbar spinal cord. Histological examination of the involved ... Schistosomiasis Mansoni of the Spinal Cord R. M. Rosenbaum, N. Ishii, H. Tanowitz and M. Wittner ... The present report is the third biopsy-proven case of S. mansoni of the spinal cord in continental United States. ... Analysis of existing health statistics reveals that tuberculosis may be emerging as the leading infectious cause of disability ...
... also known as spinal muscular atrophy) is an autosomal recessive hereditary disease characterized by progressive hypotonia and ... muscle weakness occurs because of a progressive degeneration of the alpha motor neuron from anterior horn cells in the spinal ... Spinal muscle atrophy. By age 9 years, this patient with type I spinal muscle atrophy now has thoracic curve of 60° and lumbar ... Spinal muscle atrophy. Follow-up radiographs in patient at age 13 years reveal some spinal decompensation. Note so-called ...
At that time, he presented with symptoms of lumbar spinal stenosis and neurogenic claudication due to a L4-L5 Grade I ... The lumbar MRI scan reveals severe spinal stenosis at L4-L5 with a Grade I spondylolisthesis, and stenosis at L2-L3. ... At that time, he presented with symptoms of lumbar spinal stenosis and neurogenic claudication due to a L4-L5 Grade I ... Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective long-term study comparing fusion and pseudarthrosis. ...
Spinal tap or lumbar puncture is a test to diagnose serious infections and conditions like multiple sclerosis. In this test, ... A spinal tap is also known as a lumbar puncture. A spinal tap is a test in which a sample of the CSF (cerebrospinal fluid) is ... NKorea In Panic - US Army Reveals Secret Weapon. Home , Health .membershipBar {border: 0px solid #777;background: #ccc;padding ... Before performing a lumbar puncture, the doctors check whether the patient is allergic to any medications. The spinal tap test ...
Lumbar puncture revealed a normal spinal-fluid pressure, protein, sugar and colloidal-gold curve. An electroencephalogram was ... A repeat electroencephalogram 3 days later revealed no marked change.. X-ray films of the skull, knees, shoulders and an ... X-ray study of the teeth revealed extensive caries involving the deciduous teeth, and several permanent teeth were loose. ...
A 23-gauge 3.5-inch spinal needle was inserted into the right Z-joint. Withdrawal revealed serosanguinous fluid. Contrast ... Home , December 2009 - Volume 88 - Issue 12 , Percutaneous Rupture of a Lumbar Synovial Facet Cyst ... The option of a spinal injection procedure was discussed, and he wanted to proceed with that. The procedure performed was a ... After the right L5 spinal nerve injection was performed, the right L4-L5 Z-joint (facet) was identified under fluoroscopy. The ...
The differential diagnosis includes spinal cord compression secondary to vertebral fracture or space-occupying lesion, spinal ... Spinal cord emergencies are uncommon, but injury must be recognized early so that the diagnosis can be quickly confirmed and ... The most important information in the assessment of a possible spinal cord emergency comes from the history and the clinical ... infection or abscess, vascular or hematologic damage, severe disc herniation and spinal stenosis. ...
In this article, we will examine the challenges and findings of researchers looking for the optimal treatment for lumbar spinal ... The use of Prolotherapy and stem cell therapy for spinal stenosis treatment. ... you make the appointment at the doctor and your trip to the doctor or health care provider reveals a diagnosis of lumbar spinal ... Management of lumbar spinal stenosis. BMJ. 2016 Jan 4;352:h6234. [Google Scholar]. 8 Genevay S, Atlas SJ. Lumbar spinal ...
All lumbar vertebral bodies are of normal heights and reveal normal MR signal. Disc dehyderation throughout lumbar spine with ... Conus medullaris reveals normal MR signal. Multi level central canal and lateral recess stenosis throughout lumbar spine due to ... Scoliosis with increased lordosis of lumbar spine.. - Grade I anterior listhesis of L4 over L5 with spinal stenosis of mild to ... Transitional segment at lumbar spine is noted. Increased lumbar lordosis with mild scoliosis is seen. Grade I anterior ...
Lumbar puncture (spinal tap) may be performed to aid in determining the cause when infection is suspected. ... Computed tomography (CT ) and magnetic resonance imaging (MRI) reveal enlarged ventricles and may indicate a specific cause of ... Cerebrospinal fluid- Fluid that circulates throughout the cerebral ventricles and around the spinal cord within the spinal ... Lumbar puncture (spinal tap) may be performed to aid in determining the cause when infection is suspected. ...
In some cases, your doctor may need to perform a lumbar puncture, or spinal tap. This involves the removal of a small amount of ... This exam can reveal any increased pressure within the brain, which can occur from swelling. CT and MRI scans can also be used ... cerebral spinal fluid to test for any problems other than an infection. A lumbar puncture will not be performed if any ...
3] 18F-FDG PET/MRI in Chronic Sciatica: Early Results Revealing Spinal and Non-spinal Abnormalities. The Journal of Nuclear ... In carefully selected patients diagnosed with lumbar disc prolapse, surgical discectomy may ameliorate symptoms that are ... Even when MRI revealed multiple defects, the highly localized and increased uptake of 18F-FDG was diagnostic of pain. ... In this study, the diagnosis of sciatica triggered by spinal nerve impingement was based on the increased 18F-FDG uptake ...
  • Magnetic resonance imaging (MRI) of the lumbar spine revealed a solitary intraspinal posterior epidural lesion of 1.8 × 1.5 × 0.5 cm at the L2-L3 level with heterogeneous signal intensities and adjacent epidural fatty hypertrophy contributing to severe canal stenosis (3 mm). (hindawi.com)
  • Owing to the heterogeneous signal intensities, computerized topography (CT) was performed which revealed the presence of an osseous lesion attached to the right L2 inferior articular process causing severe secondary canal stenosis (Figure 3 ). (hindawi.com)
  • MRI of the spine revealed mild cervical spinal stenosis and homogeneous enhancement of the cauda equina consistent with meningitis. (cdc.gov)
  • At that time, he presented with symptoms of lumbar spinal stenosis and neurogenic claudication due to a L4-L5 Grade I spondylolisthesis and stenosis (L2-L3). (spineuniverse.com)
  • The lumbar MRI scan reveals severe spinal stenosis at L4-L5 with a Grade I spondylolisthesis, and stenosis at L2-L3. (spineuniverse.com)
  • The differential diagnosis includes spinal cord compression secondary to vertebral fracture or space-occupying lesion, spinal infection or abscess, vascular or hematologic damage, severe disc herniation and spinal stenosis. (aafp.org)
  • In this article, we will examine the challenges and findings of researchers looking for the optimal treatment of lumbar spinal stenosis. (caringmedical.com)
  • Eventually, you make the appointment at the doctor and your trip to the doctor or health care provider reveals a diagnosis of lumbar spinal stenosis. (caringmedical.com)
  • I went to the doctor, I had an MRI and the doctor told me I had spinal stenosis. (caringmedical.com)
  • Degenerative lumbar foraminal stenosis or lateral stenosis or Neural foraminal stenosis. (caringmedical.com)
  • The diagnosis names listed above all refer to the most common type of lumbar spinal stenosis. (caringmedical.com)
  • Many people suffering from spinal stenosis do very well with surgery. (caringmedical.com)
  • Spinal Stenosis is the result of degenerative arthritis. (caringmedical.com)
  • When I was a medical student thirty years ago, the traditional treatment for spinal stenosis was a laminectomy surgery. (caringmedical.com)
  • In decompression fusion, the spinal cord is given its room and the vertebrae are fused to prevent future stenosis at that segment level. (caringmedical.com)
  • Because there is a fusion to stabilize the vertebrae, this gives us the understanding that the cause of stenosis is spinal instability. (caringmedical.com)
  • Brain MRI revealed cerebral infarction with multiple intracranial arterial stenosis and convexal subarachnoid hemorrhage. (unboundmedicine.com)
  • After experiencing lower back pain and discomfort, a lumbar MRI revealed that I have L3-L5 spinal stenosis. (timescolonist.com)
  • Spinal stenosis is the narrowing of bony structures of the spine, usually by degenerative arthritis, which may lead to compression of the spinal cord or nerve roots. (timescolonist.com)
  • Multi level central canal and lateral recess stenosis throughout lumbar spine due to ligamentum flavum hypertrophy, facet degenerative changes, scoliosis and circumferential disc bulges is seen. (healthboards.com)
  • At L4-5, there is mild to moderate stenosis of spinal canal and foramina, further compounded by a small diffuse disc protrusion. (healthboards.com)
  • Grade I anterior listhesis of L4 over L5 with spinal stenosis of mild to moderate degree involving the canal and foramina compounded by a diffuse degenerated protruding disc. (healthboards.com)
  • Supported by kind and knowledgeable professionals and with access to high quality private healthcare facilities, he provides the best quality care for patients with problems affecting the neck and back such as sciatica, slipped disc, cervical spondylosis, osteoporosis and spinal stenosis. (privatehealth.co.uk)
  • Well known for his sympathetic, kind and friendly manner, Mr Fagan has a special interest in state of the art treatment of conditions giving rise to back and neck pain in adults, such as slipped disc, spinal stenosis or stress fractures (spondylolysis). (privatehealth.co.uk)
  • however, the MRI of the lumbar spine demonstrated severe stenosis (narrowing) of the spinal canal. (justia.com)
  • This article focuses on the evaluation and management of lumbar spinal stenosis (LSS), the most common condition for which older adults undergo spinal surgery. (chiro.org)
  • Lumbar spinal stenosis exists not uncommonly in older adults with CLBP and management often can be accomplished without surgery. (chiro.org)
  • Lumbar spinal stenosis (LSS) is a common source of pain and diminished function among older adults with chronic low back pain (CLBP). (chiro.org)
  • 2 ] Lumbar spinal stenosis is the most common indication for spinal surgery among Medicare recipients, [ 3, 4 ] occurring at a rate of 135.5 surgeries per 100,000 Medicare beneficiaries in 2007. (chiro.org)
  • 10 ] Lumbar spinal stenosis can co-occur with these and other chronic conditions and thus may be an important contributor to a syndrome of functional compromise in older adults. (chiro.org)
  • Total facetectomy with/without fusion and facet-preserving microforaminotomy have been performed as conventional surgical treatments for lumbar foraminal stenosis (LFS). (nih.gov)
  • 8. An MRI of the cervical spine performed on August 20, 2006 revealed 'C5-C6 and C6-C7 degenerative disc disease and spondylosis with mild spinal stenosis ….moderate bilateral C6-C7 neural foraminal narrowing…' (Exhibit 8). (mass.gov)
  • Further work-up revealed degenerative changes in his lumbar spine and he underwent a laminectomy at L4-5 for significant stenosis. (upmc.edu)
  • The authors report the case of a woman with a history of extensive gout, emphasizing the clinical, radiological, and pathological features of a lumbar spinal stenosis. (thejns.org)
  • Neurogenic claudication (NC), also known as pseudoclaudication, is the most common symptom of lumbar spinal stenosis (LSS) and describes intermittent leg pain from impingement of the nerves emanating from the spinal cord. (wikipedia.org)
  • The term neurogenic claudication is sometimes used interchangeably with spinal stenosis. (wikipedia.org)
  • NC does not occur by itself, but rather, is associated with other underlying spinal or neurological conditions such as spinal stenosis or abnormalities and degenerative changes in the spine. (wikipedia.org)
  • Diagnosis of neurogenic claudication is based on typical clinical features, the physical exam, and findings of spinal stenosis on Computer Tomography (CT) or X-Ray imaging. (wikipedia.org)
  • MRI of the cervical spine displayed mild narrowing of the spinal cord and the right neural foramina at the C5-6 level. (cdc.gov)
  • Spinal mobility in the cervical and lumbar spine correlates with magnetic resonance imaging findings for inflammatory and structural changes in patients with active ankylosing spondylitis. (medworm.com)
  • Lateral radiographs of the cervical and lumbar spine (baseline and 2 years) were assessed for new bone formation (syndesmophyte formation and/or growth combined), and spinal MRIs were asse. (medworm.com)
  • The spine is divided into four sections: the cervical, thoracic, lumbar and sacrococcygeal vertebrae. (aafp.org)
  • Spinal MRI revealed spinal hemorrhage in the cervical, thoracic, and part of the lumbar spine. (unboundmedicine.com)
  • Physical examination revealed a palpable lymph node (3 × 4 cm) at the left cervical lymph node, lower extremity strength of 4 on a 5-point scale ( https://www.ncbi.nlm.nih.gov/books/NBK436008/ ), and decreased deep tendon reflexes. (cdc.gov)
  • MRI spine revealed myelitis of the lower cervical and upper thoracic spinal cord and radiculitis of the cauda equina. (medalerts.org)
  • MRI brain and spinal cord showed myelitis involving anterior aspect of lower cervical and upper thoracic spinal column from C6 to T1 and radiculitis of cauda equina. (medalerts.org)
  • This is a board who has mostly cervical patients, however many of us also have lumbar problems. (healthboards.com)
  • A search of the literature revealed no reports of symptomatic postoperative cervical spinal cord tethering. (thejns.org)
  • The authors present five cases of delayed postoperative cervical spinal cord tethering and discuss the benefit of detethering in these patients. (thejns.org)
  • On September 11, 2003, Dr. Pasarin ordered cervical, thoracic, and lumbar MRIs, which revealed compression in both the lower back and neck. (justia.com)
  • This neurosurgeon concluded that Saunders should undergo a second lumbar surgery -3- and, at a later date, a cervical spine surgery. (justia.com)
  • Lumbar segments were the mostly affected sites (23/24), followed by the sacral segments and cauda equina (20/24), cervical (5/24) and thoracic (5/24) segments. (scielo.br)
  • 3 , 6 This phenomenon is in marked contrast with the reflex expulsive ejaculations that are observed in men with higher spinal lesions (for example, cervical or thoracic lesions). (nature.com)
  • There is little to no evidence that two surgical procedures used to fuse crumbled vertebrae following a spinal fracture caused by osteoporosis reduce pain for patients any better than non-surgical or placebo procedures, according to a new report from a global task force of bone health experts published today in the Journal of Bone and Mineral Research. (news-medical.net)
  • Additionally, chronic disease can weaken the anterior spinal ligament, making the space between the vertebrae and the retroperitoneum lessen, favoring the emergence of vascular or visceral lesions. (sages.org)
  • Spinal Magnetic Resonance Imaging revealed intradural extramedullary mass lesions located at the thoracic 2-3 and lumbar 5 vertebrae levels. (isciii.es)
  • They presented with symptoms and signs due to cord compression at the lower thoracic and lumbar vertebrae. (who.int)
  • In both children and adults, neuromuscular and skeletal disorders such as cerebral palsy, muscular dystrophy, and arthritis can contribute to the degeneration of tissue around the lumbar vertebrae , leading to scoliosis. (wisegeek.com)
  • A skilled surgeon can perform a spinal fusion , a procedure in which two or more vertebrae are permanently fused together to prevent scoliosis from getting worse. (wisegeek.com)
  • A lumbar puncture revealed multiple oligoclonal bands in the cerebral spinal fluid. (nottingham.ac.uk)
  • This involves the removal of a small amount of cerebral spinal fluid to test for any problems other than an infection. (healthline.com)
  • Cerebral spinal fluid analysis: What does it show? (medicalnewstoday.com)
  • An examination of the cerebral spinal fluid (CSF) reveals enough information to make a diagnosis and implement a treatment plan. (livestrong.com)
  • Upon magnetic resonance imaging, the 'hour-glass' subdural compression appeared as a T1-hypointense, T2-hyperintense ovoidal area suggestive of cerebral spinal fluid collection, compatible with hydrosyringomyelia. (ovid.com)
  • A lumbar puncture revealed a CSF pleocytosis ( Table ). (cdc.gov)
  • Repeated lumbar puncture revealed increased cerebro-spinal fluid (CSF) pressure and protein content. (hindawi.com)
  • Messori A, Rychlicki F, Salvolini U (2002) Spinal epidural en-plaque meningioma with an unusual pattern of calcification in a 14-year-old girl: case report and review of the literature. (springer.com)
  • She received combined spinal-epidural anesthesia from anesthesiologist A, and delivered a healthy baby. (cdc.gov)
  • To determine whether other cases of health-care--associated bacterial meningitis had occurred, the hospital conducted a 6-month retrospective review among postpartum patients who received combined spinal-epidural anesthesia. (cdc.gov)
  • CSF leaks may follow diagnostic or therapeutic lumbar puncture as well as spinal anesthesia and after an inadvertant puncture of the dura following epidural anesthesia or epidural steroid injections (Johkura et al. (dizziness-and-balance.com)
  • 1,5 The last complication is exceptional, but it has been described after epidural anaesthesia, myelography, and diagnostic lumbar puncture. (elsevier.es)
  • Tophaceous gout of the lumbar spine mimicking an epidural abscess: MR features. (thejns.org)
  • 1949 - 1952 1996 Bonaldi VM Duong H Starr MR Sarazin L Richardson J: Tophaceous gout of the lumbar spine mimicking an epidural abscess: MR features. (thejns.org)
  • Tophaceous lumbar gout mimicking an epidural abscess. (thejns.org)
  • 216 1998 Gines R Bates DJ: Tophaceous lumbar gout mimicking an epidural abscess. (thejns.org)
  • a): axial T1-weighted contrast-enhanced MRI, (b) axial fluid-attenuated inversion recovery (FLAIR), and (c) sagittal T1-weighted contrast-enhanced MRI revealed a hyperintense lesion on the right cingulate gyrus with slight local mass effect (arrows). (hindawi.com)
  • In this study, the diagnosis of sciatica triggered by spinal nerve impingement was based on the increased 18 F-FDG uptake suggesting a potentially painful lesion, while the MRI indicated the lesion type associated with pathologies such as tumor, facet synovitis, herniated disc or other causes. (gehealthcare.com)
  • Unfortunately, the injections fail to provide the desired results for the worker due to the size and position of the spinal lesion. (floridabar.org)
  • Spinal MRI revealed a nonenhancing T2-hyperintense lesion in the central cord at the level of T1/T2 suggesting a spinal cord edema. (aappublications.org)
  • T1-weighted MRI scan, with gadolinium, revealed a serpiginous, inhomogeneously-enhancing, intramedullary lesion extending from the conus medullaris to the T9 level (Figure 1 ). (upmc.edu)
  • Axial CT scan revealing an expansive destructive lytic lesion at the L-4 lamina and spinous process, with constriction of the cord. (thejns.org)
  • Inclusion criteria involved having a stable lesion for at least 3 months at the time of sexological consultation, with no other medical conditions than the spinal lesion that could affect sexual function (for example, diabetic patients were excluded). (nature.com)
  • In some cases, your doctor may need to perform a lumbar puncture, or spinal tap. (healthline.com)
  • Doctors usually perform a lumbar puncture on a person who is lying still in a fetal position. (medicalnewstoday.com)
  • We propose a 2-year pilot prospective, randomized, double-blind, controlled study of TNF-a inhibitor (infliximab) in patients with sciatica as a result of postoperative lumbar spinal fibrosis. (clinicaltrials.gov)
  • Led by Mr Fagan, SpineArt is a multidisciplinary clinical network providing comprehensive care for back and spinal problems, from initial assessment through to postoperative physiotherapy. (privatehealth.co.uk)
  • Postoperative radiologic images revealed significantly enlarged bilateral foramens at L5-S1 level. (nih.gov)
  • Sagittal T 2 -weighted (left) and axial T 1 -weighted lumbar MR images obtained 2 years after surgery, demonstrating postoperative changes at the previous operative site and no evidence of neural compression. (thejns.org)
  • Lumbar puncture showed increased monocyte count and cerebrospinal fluid pressure. (ispub.com)
  • Culture of the spinal fluid revealed no abnormal findings. (ispub.com)
  • A spinal tap is a test in which a sample of the CSF (cerebrospinal fluid) is taken to diagnose suspected diseases like multiple sclerosis. (newsmax.com)
  • CSF is a colorless fluid that helps in delivering nutrients to the spinal cord and brain. (newsmax.com)
  • A lumbar puncture is performed to measure the pressure of cerebrospinal fluid. (newsmax.com)
  • Withdrawal revealed serosanguinous fluid. (lww.com)
  • A lumbar puncture ("spinal tap") checks for leukemia cells in the fluid around the brain and spinal cord. (umm.edu)
  • A doctor will collect a sample of fluid from a person's lower back during a procedure called a lumbar puncture, which is also known as a spinal tap. (medicalnewstoday.com)
  • Cerebrospinal fluid protects the brain and spinal cord. (medicalnewstoday.com)
  • If a person has a condition that affects the CNS, it will disrupt the blood-brain barrier, which can usually be detected by changes in the composition of the spinal fluid. (medicalnewstoday.com)
  • Low cerebrospinal fluid (CSF) pressure headache is caused by an internal spinal fluid leak and may range from obvious and disabling to subtle and nagging. (hopkinsmedicine.org)
  • The brain normally sits inside a "bag" filled with spinal fluid that extends down from the skull into the spine. (hopkinsmedicine.org)
  • MRI of the neck and back occasionally reveals spinal fluid leaking out of its normal location. (hopkinsmedicine.org)
  • Computed tomography (CT) myelogram (a CT scan of the back after dye is injected into the spinal fluid) may reveal the site of the leak directly. (hopkinsmedicine.org)
  • CSF cisternogram - a procedure in which a radioactive dye is injected in the spinal fluid and detected by a special radiation-detecting camera - may reveal the leak directly, or may only show indirect evidence of the leak's presence but not its exact location. (hopkinsmedicine.org)
  • Lumbar puncture (spinal tap) may reveal lower than normal spinal fluid pressure, but might increase the severity of the symptoms temporarily. (hopkinsmedicine.org)
  • A computed tomography (CT) revealed air in the spinal canal adjacent to the surgery site, pneumoperitoneum and free fluid in the paracolic gutter. (sages.org)
  • The middle layer, the arachnoid, is important because of its involvement in the normal flow of the cerebrospinal fluid (CSF), a lubricating and nutritive fluid that bathes both the brain and the spinal cord. (thefreedictionary.com)
  • A needle inserted into your lower back removes a small amount of cerebrospinal fluid (CSF), the protective fluid that surrounds the brain and spinal column. (mayoclinic.org)
  • Cerebrospinal fluid (CSF) collection is a test to look at the fluid that surrounds the brain and spinal cord. (sutterhealth.org)
  • The test is also used to measure pressure in the spinal fluid. (sutterhealth.org)
  • Lumbar puncture with fluid collection may also be part of other procedures such as an x-ray or CT scan after dye has been inserted into the CSF. (sutterhealth.org)
  • Lumbar punctures (LPs) are interventional procedures that are used to collect cerebrospinal fluid. (spiedigitallibrary.org)
  • RT-PCR on total RNA derived from adult cerebral cortex, brainstem, spinal cord, and sciatic nerve detects Cre message only brain and spinal cord, but not in sciatic nerve, liver, spleen, and kidney (latter three not shown). (rupress.org)
  • The procedure performed was a right L5 spinal nerve injection, right zygapophysial (Z-joint) injection (L4-L5 intra-articular facet), and intentional rupture of the synovial facet cyst. (lww.com)
  • After the right L5 spinal nerve injection was performed, the right L4-L5 Z-joint (facet) was identified under fluoroscopy. (lww.com)
  • Cysts encroach the neuroforamen and cause spinal nerve irritation and radiculopathy. (lww.com)
  • The spinal cord and nerve roots are protected within these structures. (aafp.org)
  • The approach has been shown to significantly reduce motion-induced errors by combining PET and MRI, and facilitated the detection of specific pain sources (herniated disc, degenerated facet joints, and spinal nerve impingement) in sciatica. (gehealthcare.com)
  • Based on morphological insights obtained by MRI combined with the increased 18 F-FDG uptake, the researchers identified spinal nerve impingement caused by a herniated disc in half of all the patients investigated. (gehealthcare.com)
  • Ophthalmic examination may reveal uveitis, retinal or optic nerve oedema, and in more serious cases, retinal detachment. (pubmedcentralcanada.ca)
  • B ) Close-up from ( A ) with nerve suction electrodes (with silver wires), an intracellular electrodes and the 3 silicon probes (green) inserted into the spinal cord. (elifesciences.org)
  • 1,2 The main complications of the procedure are post-lumbar puncture headache (PPH) and transient nerve root irritation. (elsevier.es)
  • A follow up diagnos tic test revealed acute lumbar radiculopathy-lower back pain caused by compression, inflammation and/or injury to a spinal nerve root. (justia.com)
  • NC is a medical condition most commonly caused by damage and compression to the lower spinal nerve roots. (wikipedia.org)
  • The International Association for the Study of Pain defines neurogenic claudication as, "pain from intermittent compression and/or ischemia of a single or multiple nerve roots within an intervertebral foramen or the central spinal canal. (wikipedia.org)
  • Surgical treatments are predominantly used to relieve pressure on the spinal nerve roots and are used when nonsurgical interventions are ineffective or show no effective progress. (wikipedia.org)
  • Before performing a lumbar puncture, the doctors check whether the patient is allergic to any medications. (newsmax.com)
  • During the acute phase of trypanosomiasis, the CBC count may reveal leukocytosis with relative lymphocytosis, and transaminase levels are often elevated. (medscape.com)
  • Pearn J. Genetic studies of acute infantile spinal muscular atrophy (SMA type I). An analysis of sex ratios, segregation ratios, and sex influence. (medscape.com)
  • Hounsgaard, J., Hultborn, H., Jespersen, B. & Kiehn, O. Bistability of α-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. (nature.com)
  • In contrast, despite the fact that the vast majority of neurons in the spinal cord are interneurons, with few exceptions ( Shiga and Oppenheim, 1991 ) the early molecular development of this population of cells is the least well studied. (jneurosci.org)
  • Functional properties of lamina X neurons in the spinal cord remain unknown despite the established role of this area for somatosensory integration, visceral nociception, autonomic regulation and motoneuron output modulation. (frontiersin.org)
  • A review of the pertinent literature indicates that biopsy-proven schistosomiasis of the spinal cord is rare. (ajtmh.org)
  • ABSTRACT Schistosomiasis of the spinal cord is an uncommon but potentially curable form of schistosomiasis, if diagnosed and managed early. (who.int)
  • This paper describes the clinical manifestations, diagnosis and management of schistosomiasis of the spinal cord in 5 patients attending Shaab and Ibn Khuldoun Hospitals, Khartoum from 1997 to 2007. (who.int)
  • This is the diagnosis when the central canal, where the spinal cord rests within the spine is closing in on the spinal cord. (caringmedical.com)
  • CSF helps keep the pressure in the skull cavity and spinal canal at constant levels. (medicalnewstoday.com)
  • Magnetic resonance imaging of the spine revealed an intradural extramedullary mass occupying the spinal canal at the level of T10-L3. (tripdatabase.com)
  • Sagittal T 2 -weighted (left) and axial T 1 -weighted (right) MR images revealing the lamina bilaterally and the spinous process of L-4 infiltrated by tissue with expansion of the relevant osseous structures, extending into the spinal canal and compressing the thecal sac from behind. (thejns.org)
  • We report a very rare case of a solitary lumbar intraspinal osteolipoma, presenting as a cauda equina syndrome. (hindawi.com)
  • MRI now ruled out local tumor progression but revealed meningeal contrast enhancement along the medulla, the myelon, and the cauda equina. (hindawi.com)
  • Although intraspinal osteolipomas are benign lesions and generally have good prognosis, they need to be removed en bloc as they may result in rapid neurological deterioration. (hindawi.com)
  • D'Aliberti G, Talamonti G, Villa F (2008) Anterior approach to thoracic and lumbar spine lesions: results in 145 consecutive cases. (springer.com)
  • MRI revealed multiple demyelinating lesions in the brain and another in the spinal cord at D8 with no contrast uptake. (elsevier.es)
  • He underwent total excision of these spinal lesions. (isciii.es)
  • Spinal cord injuries are usually associated with anejaculation, but few premature ejaculations (PE) are described in lumbosacral lesions. (nature.com)
  • Gottfried ON, Gluf W, Quinones-Hinojosa A (2003) Spinal meningiomas: surgical management and outcome. (springer.com)
  • Surgical treatment consisted in (1) placement of an ommaya reservoir for daily CSF puncture, (2) Spinal dural biopsy confirming leptomeningeal oligodendroglioma metastasis, and (3) ventriculo-peritoneal shunt placement after CSF protein has decreased to 1500-2000 mg/l. (hindawi.com)
  • We report the case of a 38-year-old male with secondary cranial and spinal leptomeningeal tumor dissemination 8 months after surgical resection of an anaplastic oligodendroglioma WHO grade III of the right frontal lobe. (hindawi.com)
  • Unfortunately, years later, many of these surgical patients would develop worsening spinal arthritis and would have worse symptoms than those that sent them to the original surgery. (caringmedical.com)
  • In June 2007, the Healthcare Infection Control Practices Advisory Committee (HICPAC) recommended for the first time that surgical masks be worn by spinal procedure operators to prevent infections associated with these procedures ( 1 ). (cdc.gov)
  • With access to an onsite MRI scanner and a Level 2 High Dependency Unit (HDU), their aim is to offer the best care for elective spinal surgical patients in the region. (privatehealth.co.uk)
  • Spinal cord dissemination over 10 years after surgical removal of the fourth ventricle ependymoma without local recurrence is extremely rare. (isciii.es)
  • Spinal decompression is the main surgical intervention and is the most common back surgery in patients over 65. (wikipedia.org)
  • We discuss a case of an osteochondroma in the lumbar spine causing spinal compression - giving symptoms of weakness in the right leg, and in the L5 and S1 distribution. (scielo.org.za)
  • Neurological examinations reveal weakness and other signs. (medhelp.org)
  • Neurologic examination revealed right leg weakness and sensory deficits with a sensory level at T5. (aappublications.org)
  • AT/RT is infrequently located in the spinal cord.A 16-month-old boy presented with progressive urinary retention and weakness of the lower extremities. (tripdatabase.com)
  • The physical examination revealed weakness in Saunders s finger extensors. (justia.com)
  • Dr. Pasarin conducted a physical exam of Saunders, which revealed weakness in his upper extremities and abnormal reflexes in his arms. (justia.com)
  • Atypical teratoid/rhabdoid tumor of lumbar spine in a toddler child Atypical teratoid/rhabdoid tumor (AT/RT) is a rare pediatric central nervous system malignancy with poor outcome. (tripdatabase.com)
  • MRI or CT images can reveal any swelling of the brain or another condition that might be causing your symptoms, such as a tumor. (mayoclinic.org)
  • Stryker's Spine division today announced the publication of a pre-clinical animal study comparing the performance of spinal implants made from a variety of materials, which illustrated the bone in-growth and biological fixation capabilities of its 3D-printed Tritanium cages. (news-medical.net)
  • We present the first case of lumbar intraspinal osteolipoma and have discussed its clinical presentation, diagnostic challenges, and management along with a pertinent review of literature. (hindawi.com)
  • Panigrahi I, Kesari A, Phadke SR, Mittal B. Clinical and molecular diagnosis of spinal muscular atrophy. (medscape.com)
  • The most important information in the assessment of a possible spinal cord emergency comes from the history and the clinical evaluation. (aafp.org)
  • Clinical studies have demonstrated a significant association between lumbar spinal fibrosis after lumbar discectomy and the recurrence of radicular pain in 25% of cases. (clinicaltrials.gov)
  • The clinical manifestations posterior to an intestinal injury by lumbar instrumentation are nonspecific. (sages.org)
  • Mr Dan Fagan is Consultant Spinal Surgeon at SpineArt in Yarm, a specialist clinical network covering the Northeast and North Yorkshire. (privatehealth.co.uk)
  • Clinical and pathological features of bovine lymphoma involving the spinal cord were evaluated through a retrospective study of the necropsy database from 2005 to 2017. (scielo.br)
  • However, the former is a clinical term, while the latter more specifically describes the condition of spinal narrowing. (wikipedia.org)
  • Surgery was scheduled performing a laminectomy with discectomy and lumbar spinal instrumentation in the intervertebral spaces L4-L5 and L5-S1. (sages.org)
  • A diagnostic thoraco-lumbar laminectomy and spinal cord biopsy was performed. (upmc.edu)
  • Lumbar puncture repeatedly revealed yellow and muddy CSF with an increased opening pressure of about 50 cm H 2 O. CSF examination showed marked elevation of protein (15972 mg/l), slightly elevated cell count (16/ L), and normal glucose and lactate. (hindawi.com)
  • Histological examination of the involved portion of cord suggested the presence of an ectopic female adult worm in an adjacent spinal vein may have been responsible. (ajtmh.org)
  • The patient's physical examination demonstrated diminished lordosis with limited range of motion of the lumbar spine. (spineuniverse.com)
  • The examination revealed a well-healed incision without any drainage or erythema. (spineuniverse.com)
  • Examination revealed decreased pin-prick and temperature sensation on the left below the T8 level. (ajnr.org)
  • Physical examination revealed absent peristalsis and rebound tenderness, without hemodynamic compromise. (sages.org)
  • Neurologic examination revealed reduced sensibility to all modalities, a positive Romberg test, and vertigo. (aappublications.org)
  • The examination revealed overall strength of 2/5 in the lower limbs, absence of deep tendon reflexes, and bilaterally absent plantar reflex. (elsevier.es)
  • The subarachnoid spaces posterior to the spinal cord were normal. (ajnr.org)
  • On the basis of these studies, a diagnosis of transdural herniation of the spinal cord at the T6 level was made, with no evidence of a posterior intradural arachnoid cyst. (ajnr.org)
  • Bowel perforation after posterior spinal instrumentation: A rare complication. (sages.org)
  • Intestinal perforation is a rare complication of lumbar instrumentation on a posterior approach. (sages.org)
  • Early diagnosis can prevent fatal outcomes, so it is of great importance to include intestinal perforation in the diagnosis of patients with abdominal pain posterior to lumbar instrumentation. (sages.org)
  • Although the majority of the recurrences take place within a few years after surgery, we experienced a case with multiple spinal disseminations 12 years after the resection of the fourth ventricle ependymoma and administration of the radiation therapy to the posterior fossa. (isciii.es)
  • Two primary ovarian pregnancies and 1 heterotopic pregnancy (uterine and ovarian) had somatic dysfunction at the T10-T11 spinal levels and CRPs posterior for the ovary, 1 primary omental pregnancy with somatic dysfunction at the T9-T12 spinal levels and CRPs anterior and posterior for the ileum and jejunum, and 1 tubal pregnancy with somatic dysfunction at the T10-L1 spinal levels and CRPs anterior and posterior for the fallopian tube. (jaoa.org)
  • These symptoms are relieved with sitting or lumbar flexion. (spineuniverse.com)
  • 6 ] It is theorized that since extension of the spine and weight-bearing forces cause greater narrowing of the spinal canals [ 7, 8 ] that the symptoms of LSS are exacerbated by standing, walking and bending backwards and relieved by sitting, lying or forward flexion movements. (chiro.org)
  • A positive "shopping cart sign" refers to the worsening of pain with spinal extension and improvement with spinal flexion. (wikipedia.org)
  • Findings from electromyography (EMG) in patients with SMA are characteristic of a neuropathic disorder, revealing fibrillation potentials, denervation, and increased amplitude. (medscape.com)
  • Which physical findings are characteristic of type II spinal muscle atrophy (SMA)? (medscape.com)
  • The findings underscore the need to follow established infection-control recommendations during spinal procedures, including the use of a mask and adherence to aseptic technique. (cdc.gov)
  • Cerebral MRI revealed no pathologic findings. (aappublications.org)
  • Magnetic resonance imaging (MRI) scans revealed diploe and thick skull with outer table erosion appearing as "worm-eaten" spots (Fig. 2). (ispub.com)
  • Authors: Baraliakos X, Hermann KA, Xu S, Hsia EC, Braun J Abstract OBJECTIVES: We aimed to assess relationships between single Bath Ankylosing Spondylitis Metrology Index (BASMI) components and corresponding spinal segment magnetic resonance images (MRI) in anti-tumour-necrosis-factor-treated AS patients. (medworm.com)
  • Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis. (medworm.com)
  • Abstract Objective: To evaluate the association between trabecular bone score (TBS) and new bone formation in ankylosing spondylitis (AS) patients, and to investigate whether TBS is independently associated with new bone formation.Method: Sixty-eight patients with AS underwent spinal magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry of the lumbar spine to measure TBS and bone mineral density at baseline. (medworm.com)
  • His lumbar magnetic resonance imaging confirmed a right L4-L5 facet cyst ( Fig. 1 ). (lww.com)
  • 1. Doyle A, Merrilees M: Synovial cysts of the lumbar facet joints in a symptomatic population: Prevalence on magnetic resonance imaging. (lww.com)
  • Magnetic resonance imaging demonstrated a mildly decreased intradiscal T2 signal with shallow central subligamentous disk displacement and low-grade facet arthropathy at L5/S1, a hypolordotic lumbar curvature, and accessory superior bundles of the right piriformis muscle without morphologic magnetic resonance imaging evidence of piriformis syndrome. (chiro.org)
  • Magnetic resonance imaging reveals lumbar spinal fibrosis by a hyposignal in the T1 sequence and a hypersignal in T2 sequence around the spinal tissue. (clinicaltrials.gov)
  • The physician can also take x-rays and magnetic resonance imaging ( MRI ) scans of the lumbar region. (wisegeek.com)
  • Physical therapy and spinal injections provided minimal relief of symptoms. (spineuniverse.com)
  • If your doctor orders a lumbar puncture test for you, he does so based on your symptoms. (livestrong.com)
  • If you look at the broader picture then the symptoms could be due to MS, muscular dystrophy, benign intracranial hypertension, Parkinson's disease, brain or spinal cord injury. (medhelp.org)
  • Lumbar scoliosis can result in several different signs and symptoms. (wisegeek.com)
  • I can wholeheartedly relate to the symptoms of lumbar scoliosis. (wisegeek.com)
  • These variables were measured in real time by fast-cyclic voltammetry in the decerebrate cat's lumbar spinal cord during fictive locomotion, which was evoked by electrical stimulation of the mesencephalic locomotor region (MLR) and registered as integrated activity in bilateral peripheral nerves to hindlimb muscles. (frontiersin.org)
  • It surrounds and protects the brain and the spinal cord, which make up the central nervous system (CNS). (medicalnewstoday.com)
  • CSF surrounds and protects the brain and the spinal cord. (medicalnewstoday.com)
  • Meningitis is a serious inflammation of the meninges, the thin, membranous covering of the brain and the spinal cord. (thefreedictionary.com)
  • Anterior to this intervertebral space separated only by the anterior spinal ligament, we can find the bifurcation of the aorta, the vena cava and the abdominal cavity. (sages.org)
  • A new technology that increases the safety and precision of spinal fusion surgeries while reducing the time needed for the procedure now is available at Rush University Medical Center. (news-medical.net)
  • The spinal tap test is a safe procedure and has minimal risks. (newsmax.com)
  • The option of a spinal injection procedure was discussed, and he wanted to proceed with that. (lww.com)
  • Dr. Pasarin reviewed the MRI results, ordered additional radiological diagnostic studies of Saunders s lumbar spine, and concluded that a lumbar decompression procedure was necessary. (justia.com)
  • We evaluated ten consecutive patients that underwent surgery for spinal meningiomas. (springer.com)
  • A detailed assessment revealed that his second lumbar vertebra was the site of injury. (medindia.net)
  • Spinal cord emergencies are uncommon, but injury must be recognized early so that the diagnosis can be quickly confirmed and treatment can be instituted to possibly prevent permanent loss of function. (aafp.org)
  • The calf was euthanized and the necropsy confirmed the diagnosis of segmental spinal cord hypoplasia of the lumbar tract associated to hydromyelic and syringomyelic cavities. (ovid.com)
  • For patients contemplating spinal fusion surgery to alleviate pain, bone health is an important consideration. (news-medical.net)
  • Hematoxylin and eosin-stained sections revealed bone tissue with marrow fibrosis and inflammatory cell invasion (Fig. 4). (ispub.com)
  • Fig.1 Skull X-ray showed the hypertransradiancy which reveals multiple circle, marginal irregular bone destruction. (ispub.com)
  • Fig.4 Photomicrograph of the biopsy specimen revealed a bone tissue having inflammatory cells invasion and a marrow ingredient with fiberization. (ispub.com)
  • The idea was that by cutting away the bone the spinal cord would have more room or not be compressed. (caringmedical.com)
  • Of all spinal tumours, 70% of primary bone tumours are benign. (scielo.org.za)
  • We experimentally evaluated the system using a metal-wire phantom mimicking high reflection bone structures and human spinal bone phantom. (spiedigitallibrary.org)
  • We've found that in patients with single-level lumbar degenerative disc disease, who had either fusion or ProDisc-L procedures, both groups experienced dramatic improvement after surgery, and that improvement was durable for five years. (spineuniverse.com)
  • This outcome validated surgery as a very reasonable treatment option for patients with single-level lumbar degenerative disc disease who have failed at least six months of non-operative therapy. (spineuniverse.com)
  • These studies have concentrated primarily on the most ventral and dorsal cells in the spinal cord and the signals that control the specification of these cells. (jneurosci.org)
  • A growing body of data suggests that cell fates along the d/v axis of the spinal cord are controlled in part by secreted factors emanating from the ventral midline and dorsal non-neural ectoderm. (jneurosci.org)
  • To begin to examine the early development of spinal cord interneurons, we have focused on interneurons generated in the intermediate region (IR) of the spinal cord, here defined as the area between the dorsal and ventral horns, during the early stages of cell differentiation at 9.5-11.5 dpc. (jneurosci.org)
  • Micrographs show the ventral horn of the lumbar spinal cord. (nih.gov)
  • Here we introduce an ex-vivo spinal cord preparation with both dorsal and ventral roots still attached for functional studies of the lamina X neurons and their connectivity using an oblique LED illumination for resolved visualization of lamina X neurons in a thick tissue. (frontiersin.org)
  • Sagittal T1- and T2-weighted MR sequences obtained on a 1.5-T imaging unit showed ventral displacement of the spinal cord at the level of T6 ( Fig 1A ). (ajnr.org)
  • A, Sagittal T1-weighted MR image shows ventral displacement of the spinal cord at the T6 level ( arrows ). (ajnr.org)
  • No flow is visible on the ventral side of the spinal cord at the T6 level. (ajnr.org)
  • A lumbar puncture test can help diagnose serious infections like meningitis and diagnose disorders that may affect the nervous system like multiple sclerosis. (newsmax.com)
  • These may include infections (such as meningitis) and brain or spinal cord damage. (sutterhealth.org)
  • Therefore, over the course of six to nine months, if a patient is not getting better with the therapies that help most people-that being rest, physical therapy, spinal injections, and/or anti-inflammatory medication-we have very good validation that surgery can help. (spineuniverse.com)
  • Nonsurgical interventions include drugs, physical therapy, and spinal injections. (wikipedia.org)
  • however, it has been associated with increased risk of spinal cord injury. (springer.com)
  • Upregulation of the persistent sodium current ( I NaP ) in motoneurons contributes to the development of spasticity after spinal cord injury (SCI). (nature.com)
  • Boulenguez, P. & Vinay, L. Strategies to restore motor functions after spinal cord injury. (nature.com)
  • Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. (nature.com)
  • Harvey, P.J., Li, X., Li, Y. & Bennett, D.J. 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. (nature.com)
  • Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. (nature.com)
  • Inhibiting TNF- alpha could significantly decrease spinal fibrosis after lumbar discectomy. (clinicaltrials.gov)
  • Inhibiting TNF-a could significantly decrease sciatica pain because of lumbar spinal fibrosis after lumbar discectomy by decreasing spinal fibrosis. (clinicaltrials.gov)
  • The present report is the third biopsy-proven case of S. mansoni of the spinal cord in continental United States. (ajtmh.org)
  • IFAT reveals the earliest positive results for IgM antibodies after initial infection. (medscape.com)
  • Lumbar puncture CSF sample shows no WBC, normal protein and glucose, no evidence of viral or bacterial infection. (medalerts.org)
  • It may also suggest muscle defect mimicking spinal sciatica, due to infectious or non-infectious causes, ischemia, or trauma, and may be confirmed or denied by local anesthesia to ascertain the pain origin. (gehealthcare.com)
  • Head computed tomography (CT) scan revealed a thick skull, heterogeneous diploe, and a lot of hardened macular shadow. (ispub.com)
  • Control DXA scan in her girl child aged 6.8 years revealed low BMD at the lumbar spine. (biomedsearch.com)
  • Transverse sections through the L4 spinal cord were stained for human TDP-43 immunoreactivity and then counterstained with haematoxylin. (nih.gov)
  • Histological verification: transverse ( B ) and sagittal ( C ) slices, 200 μm thick, showing the location of the silicon probes in the spinal cord (red traces and location illustrated on right, electrodes stained with DiD). (elifesciences.org)
  • MRI revealed inflammation around spinal cord consistent with transverse myelitis vs. Guillain Barre syndrome. (medalerts.org)
  • Sacko O, Haegelen C, Mendes V (2009) Spinal meningioma surgery in elderly patients with paraplegia or severe paraparesis: a multicenter study. (springer.com)
  • Pregnancy-associated spinal osteoporosis (PPSO) is a rare condition characterized by severe back pain occurring near the end of the first pregnancy or shortly afterward. (biomedsearch.com)
  • Extremely low lumbar spine BMD, L2-L4: 0.627 g/cm(2), T-score -4.8, Z-score -4.3, 52% young adult indicated severe osteoporosis. (biomedsearch.com)
  • Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3. (medscape.com)
  • Hausmanowa-Petrusewicz I, Zaremba J, Borkowska J. Chronic proximal spinal muscular atrophy of childhood and adolescence: sex influence. (medscape.com)
  • Lumbar puncture or spinal tap is also confirmatory for MS in 80-85% of the patients showing signs of chronic inflammation and oligoclonal bands. (medhelp.org)
  • Li, Y., Gorassini, M.A. & Bennett, D.J. Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats. (nature.com)
  • Spinal deformities can be caused by many different factors, including congenital disorders and arthritis , and usually result in lower back pain and chronic fatigue. (wisegeek.com)
  • A patient may be instructed to take over-the-counter or prescription medications to relieve chronic pain , and schedule regular checkups to ensure that lumbar scoliosis does not worsen. (wisegeek.com)
  • All five women had received intrapartum spinal anesthesia. (cdc.gov)
  • Anesthesiologist A reported routine use of masks during spinal anesthesia procedures. (cdc.gov)
  • Staff members reported that the presence of unmasked visitors in the room during spinal anesthesia procedures was common. (cdc.gov)
  • Subsequently, the hospital reinforced policies and procedures to enhance hand hygiene and maintenance of sterile fields, and required the use of masks, gowns, and sterile gloves for staff members performing spinal anesthesia procedures. (cdc.gov)
  • In addition, the hospital instituted new policies to minimize visitors and require masks for all persons in the room during spinal anesthesia. (cdc.gov)
  • A standardized care pathway for children with adolescent idiopathic scoliosis undergoing spinal fusion surgery reduces the need for opioid pain medications and shortens hospital stays at Children's National Health System. (news-medical.net)
  • Johnson & Johnson Medical Devices Companies, through its subsidiary Johnson & Johnson Medical GmbH, announced today the acquisition of Emerging Implant Technologies GmbH, a privately held manufacturer of 3D-printed titanium interbody implants for spinal fusion surgery, based in Wurmlingen, Germany. (news-medical.net)
  • He has not had previous lumbar spine surgery. (spineuniverse.com)
  • We see the patients who have had surgery and now in some cases have been recommended to spinal fusion surgery. (caringmedical.com)
  • In most cases, there is an obvious cause of the leak, such as a spinal tap, spinal surgery, or trauma to the head or neck. (hopkinsmedicine.org)
  • They can follow spinal surgery (Sin, 2006), where there may be a tear in the dura that surrounds the spinal cord. (dizziness-and-balance.com)
  • Spine Art is based in offices in Yarm and Mr Fagan carries out consultations and spinal surgery at three leading private hospitals in the area: Nuffield Health Tees Hospital in Stockton-on-Tees, BMI Duchy Hospital in Harrogate and BMI Woodlands Hospital in Darlington. (privatehealth.co.uk)
  • His research interests include minimal access spinal surgery, vertebral body augmentation, balloon kyphoplasty and the treatment of osteoporotic vertebral compression fractures. (privatehealth.co.uk)
  • Mr Fagan recently featured in a radio interview talking about his spinal surgery practice. (privatehealth.co.uk)
  • Recently, endoscopic spinal surgery has been introduced as a minimally invasive therapeutic modality of LFS by several authors. (nih.gov)
  • Treatments › Surgery › Long-term Lumbar (Low Back) Artificial Disc Studies Show Pos. (spineuniverse.com)
  • All lumbar vertebral bodies are of normal heights and reveal normal MR signal. (healthboards.com)
  • Even when MRI revealed multiple defects, the highly localized and increased uptake of 18 F-FDG was diagnostic of pain. (gehealthcare.com)
  • Lumbar puncture (LP) is a technique often used for diagnostic purposes and less frequently for therapeutic ends. (elsevier.es)
  • RÉSUMÉ La schistosomiase médullaire est une forme rare mais potentiellement curable de la schistosomiase, lorsque le diagnostic a été posé au début de l'affection et que la prise en charge a été rapide. (who.int)
  • Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
  • Clinicians need to be aware of the possibility of ureteric injury in hyperextension lumbar fractures occurring in ankylosing spondylitis and treat them early to avoid urological complications. (medworm.com)
  • Despite a considerable body of literature, sound evidence regarding the optimal treatment for traumatic thoracic and lumbar spine fractures is lacking. (rug.nl)
  • Medical records of patients hospitalized for traumatic spinal fractures between 1991 and 2002 were identified in 2 trauma centers in the same country with established and different treatment strategies. (rug.nl)
  • Albanese V, Platania N (2002) Spinal intradural extramedullary tumors. (springer.com)
  • Brain MRI with injected contrast dye may reveal "enhancement" of the meninges lining of the brain and sometimes indicate evidence of the brain "sagging" downward from the skull toward the neck. (hopkinsmedicine.org)
  • My neck has no spinal deformity at all, yet is a problem. (scoliosis.org)
  • Disc degeneration in the neck (C5-6 C6-7)comes in 2nd place after the lumbar. (scoliosis.org)
  • Myelography revealed deviation and thinning of subarachnoid contrast medium columns in the lumbar segment. (ovid.com)
  • Cranial computed tomography (CCT) on admission now revealed marked ventricular enlargement. (hindawi.com)
  • Contrast material revealed an arthrogram and then filled the cyst ( Fig. 2 ). (lww.com)
  • Multiplanner, multisequential, non contrast MR study of lumbar spine. (healthboards.com)
  • The intraspinal osteolipoma was excised en bloc and fusion was performed as it required partial resection of the facet joint within 24 hours of presentation. (hindawi.com)
  • The nerves that leave your spinal cord and travel around the body have to pass through a gap or opening in the spine's facet joints, the foramen. (caringmedical.com)