NEURONS in the inner nuclear layer of the RETINA that synapse with both the RETINAL PHOTORECEPTOR CELLS and the RETINAL BIPOLAR CELLS, as well as other horizontal cells. The horizontal cells modulate the sensory signal.
A common name for fish of the family Percidae, belonging to the suborder Percoidei, order PERCIFORMES.
Common name for FISHES belonging to the order Perciformes and occurring in three different families.
The common name for all members of the Rajidae family. Skates and rays are members of the same order (Rajiformes). Skates have weak electric organs.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Common name for Carassius auratus, a type of carp (CARPS).
Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.
Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.
Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.
An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
A family of freshwater fish comprising the minnows or CARPS.
##### I apologize, but the term "turtles" is not a recognized medical term or concept. It is commonly referred to as a group of reptiles with a shell, and does not have any direct relevance to medical definition.
Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.
A genus of the Ambystomatidae family. The best known species are the axolotl AMBYSTOMA MEXICANUM and the closely related tiger salamander Ambystoma tigrinum. They may retain gills and remain aquatic without developing all of the adult characteristics. However, under proper changes in the environment they metamorphose.
The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)
A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.

Afferents and homotypic neighbors regulate horizontal cell morphology, connectivity, and retinal coverage. (1/108)

Horizontal cells are inhibitory interneurons with laterally oriented dendrites that overlap one another, contacting the pedicles of cone photoreceptors. Because of their regular spacing, the network of horizontal cells provides a uniform coverage of the retinal surface. The developmental processes establishing these network properties are undefined, but cell-intrinsic instructions and interactions with other cells have each been suggested to play a role. Here, we show that the intercellular spacing of horizontal cells is essentially independent of genetic background and is predicted by local density, suggesting that horizontal cell positioning is modulated by proximity to other horizontal cells. Dendritic field area compensates for this variation in intercellular spacing, maintaining constant dendritic coverage between strains. Functional dendritic overlap is achieved anatomically at the level of the pedicles, where horizontal cells interact with one another to establish their connectivity: the number of dendritic terminals contacting a pedicle changes, reciprocally, between neighboring horizontal cells during development based on their relative proximity to each pedicle. Cellular morphology is also shown to be regulated by the afferents themselves: afferent elimination before innervation does not alter dendritic field size nor stratification but compromises dendritic branching and prevents terminal formation. Afferent and homotypic interactions therefore generate the morphology, spacing, and connectivity of horizontal cells underlying their functional coverage of the retina.  (+info)

Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse. (2/108)

Generation of center-surround antagonistic receptive fields in the outer retina occurs via inhibitory feedback modulation of presynaptic voltage-gated calcium channels in cone photoreceptor synaptic terminals. Both conventional and unconventional neurotransmitters, as well as an ephaptic effect, have been proposed, but the intercellular messaging that mediates the inhibitory feedback signal from postsynaptic horizontal cells (HCs) to cones remains unknown. We examined the possibility that proton concentration in the synaptic cleft is regulated by HCs and that it carries the feedback signal to cones. In isolated, dark-adapted goldfish retina, we assessed feedback in the responses of HCs to light and found that strengthened pH buffering reduced both rollback and the depolarization to red light. In zebrafish retinal slices loaded with Fluo-4, depolarization with elevated K(+) increased Ca signals in the synaptic terminals of cone photoreceptors. Kainic acid, which depolarizes HCs but has no direct effect on cones, depressed the K(+)-induced Ca signal, whereas CNQX, which hyperpolarizes HCs, increased the Ca signals, suggesting that polarization of HCs alters inhibitory feedback to cones. We found that these feedback signals were blocked by elevated extracellular pH buffering, as well as amiloride and divalent cations. Voltage clamp of isolated HCs revealed an amiloride-sensitive conductance that could mediate modulation of cleft pH dependent on the membrane potential of these postsynaptic cells.  (+info)

A cellular and molecular model of response kinetics and adaptation in primate cones and horizontal cells. (3/108)

A model for the sensitivity regulation in the primate outer retina is developed and validated using horizontal cell measurements from the literature. The main conclusion is that the phototransduction of the cones is the key factor regulating sensitivity. The model consists of a nonlinearity cascaded with three feedback control loops. The nonlinearity is caused by the hydrolysis of cGMP by activated phosphodiesterase. The first feedback loop is divisive, with calcium regulating the photocurrent in the cone outer segment. The second feedback loop is also divisive, with voltage-sensitive channels regulating the membrane voltage of the cone inner segment. The final feedback loop is subtractive, where the membrane voltage of the horizontal cell is subtracted from that of the cone before the cone drives the horizontal and bipolar cells. The model describes adequately the major characteristics of the horizontal cell responses to wide field, spectrally white stimuli. In particular, it shows (1) sensitivity and bandwidth control as a function of background intensity; (2) the major nonlinearities observed in the horizontal cells; and (3) the transition from linear responses toward contrast constancy (Weber's law) for background illuminances ranging from 1-1000 td.  (+info)

A non-canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina. (4/108)

Vertebrate melanopsin is a photopigment in the eye, required for photoentrainment. Melanopsin is more closely related to opsin proteins found in invertebrates, than to the other photo-pigments. Although the invertebrate melanopsin-like protein is localized in rhabdomeric photoreceptors in the invertebrate eye, it has been shown to be expressed in a subset of retinal ganglion cells in the mouse and in horizontal cells in the frog, indicating its diversified expression pattern in vertebrates. Here we show that two types of melanopsin transcripts are expressed in the developing chicken retina. Melanopsin is firstly expressed by a small subset of ganglion cells, and then prominently expressed by horizontal cells and later by bipolar cells in the developing chicken retina. This suggests that a subset of ganglion, horizontal, and bipolar cells in the chicken retina may have rhabdomeric properties in their origins.  (+info)

A comparison of release kinetics and glutamate receptor properties in shaping rod-cone differences in EPSC kinetics in the salamander retina. (5/108)

Synaptic transmission from cones is faster than transmission from rods. Using paired simultaneous recordings from photoreceptors and second-order neurones in the salamander retina, we studied the contributions of rod-cone differences in glutamate receptor properties and synaptic release rates to shaping postsynaptic responses. Depolarizing steps evoked sustained calcium currents in rods and cones that in turn produced transient excitatory postsynaptic currents (EPSCs) in horizontal and OFF bipolar cells. Cone-driven EPSCs rose and decayed faster than rod-driven EPSCs, even when comparing inputs from a rod and cone onto the same postsynaptic neurone. Thus, rod-cone differences in EPSCs reflect properties of individual rod and cone synapses. Experiments with selective AMPA and KA agonists and antagonists showed that rods and cones both contact pharmacologically similar AMPA receptors. Spontaneous miniature EPSCs (mEPSCs) exhibited unimodal distributions of amplitude and half-amplitude time width and there were no rod-cone differences in mEPSC properties. To examine how release kinetics shape the EPSC, we convolved mEPSC waveforms with empirically determined release rate functions for rods and cones. The predicted EPSC waveform closely matched the actual EPSC evoked by cones, supporting a quantal release model at the photoreceptor synapse. Convolution with the rod release function also produced a good match in rod-driven cells, although the actual EPSC was often somewhat slower than the predicted EPSC, a discrepancy partly explained by rod-rod coupling. Rod-cone differences in the rates of exocytosis are thus a major factor in producing faster cone-driven responses in second-order retinal neurones.  (+info)

Modulation by melatonin of glutamatergic synaptic transmission in the carp retina. (6/108)

Melatonin is involved in a variety of physiological functions through activating specific receptors coupled to GTP-binding protein. Melatonin and its receptors are abundant in the retina. Here we show for the first time that melatonin modulates glutamatergic synaptic transmission from cones to horizontal cells (HCs) in carp retina. Immunocytochemical data revealed the expression of the MT1 receptor on carp HCs. Whole-cell recordings further showed that melatonin of physiological concentrations potentiated glutamate-induced currents from isolated cone-driven HCs (H1 cells) in a dose-dependent manner, by increasing the efficacy and apparent affinity of the glutamate receptor. The effects of melatonin were reversed by luzindole, but not by K 185, indicating the involvement of the MT1 receptor. Like melatonin, methylene blue (MB), a guanylate cyclase inhibitor, also potentiated the glutamate currents, but internal infusion of cGMP suppressed them. The effects of melatonin were not observed in cGMP-filled and MB-incubated HCs. These results suggest that the melatonin effects may be mediated by decreasing the intracellular concentration of cGMP. Consistent with these observations, melatonin depolarized the membrane potential of H1 cells and reduced their light responses, which could also be blocked by luzindole. These effects of melatonin persisted in the presence of the antagonists of receptors for dopamine, GABA and glycine, indicating a direct action of melatonin on H1 cells. Such modulation by melatonin of glutamatergic transmission from cones to HCs is thought to be in part responsible for circadian changes in light responsiveness of cone HCs in teleost retina.  (+info)

Electrical feedback in the cone pedicle: a computational analysis. (7/108)

One of the fundamental principles of neuroscience is that direct electrical interactions between neurons are not possible without specialized electrical contacts, gap junctions, because the transmembrane resistance of neurons is typically much higher than the resistance of the adjacent extracellular space. However it has been proposed that in the retina direct electrical interactions between cones and second-order neurons occur due to the specific morphology of the cone synaptic terminal. This electrical mechanism could potentially explain the phenomenon of "negative feedback" from horizontal cells to cones and the recent finding that the tips of horizontal cell dendrites contain hemichannels has rekindled interest in the idea. We quantitatively evaluated the possibility that hemichannels and/or glutamate channels mediate electrical feedback from horizontal cells to cones. The calculations show that it is unlikely that an electrical mechanism plays a significant functional role because 1) the necessity of preserving adequate cone-to-horizontal-cell synaptic transmission limits the extracellular space resistance and the horizontal-cell dendritic transmembrane resistances to values at which the effectiveness of electrical feedback is very low and its electrical effect on the cone presynaptic membrane is negligible, 2) electrical feedback is most effective in the dark and weaker during light adaptation, which contradicts the experimental data, and 3) electrical negative feedback is associated with much stronger electrical positive feedback from horizontal cells to cones, a phenomenon that has never been reported. Therefore it is likely that negative feedback from horizontal cells to cones is chemical in nature.  (+info)

Feedback effects of horizontal cell membrane potential on cone calcium currents studied with simultaneous recordings. (8/108)

Horizontal cell (HC) to cone feedback helps establish the center-surround arrangement of visual receptive fields. It has been shown that HC activity influences cone synaptic output by altering the amplitude and voltage dependence of the calcium current (ICa) in cones. In this study, we obtained voltage-clamp recordings simultaneously from cones and HCs to directly control the membrane potential of HCs and thereby measure the influence of HC membrane potential changes on ICa in adjacent cones. Directly hyperpolarizing voltage clamped HCs produced a negative activation shift and increased the amplitude of ICa in cones. Both of these effects were abolished by enhancing extracellular pH buffering capacity with HEPES. In contrast, addition of the gap junction blocker, carbenoxolone, did not significantly alter the shifts or amplitude changes in cone ICa produced by changes in HC membrane potential. These results support the hypothesis that changes in the HC membrane potential alter the voltage dependence and amplitude of cone ICa by altering extracellular pH levels at the synapse.  (+info)

Retinal horizontal cells are a type of neuron located in the outer retina of the eye, specifically in the inner nuclear layer. These cells receive input from photoreceptors (rods and cones) and provide feedback to them through their extensive lateral connections, forming a neural network that helps in processing visual information.

Horizontal cells have dendrites that branch out and connect with multiple photoreceptor cells. They respond to light by hyperpolarizing, which means they become less excitable when exposed to light. This response is the opposite of photoreceptors, which depolarize (become more excitable) in response to light.

The primary function of retinal horizontal cells is to mediate lateral inhibition, a process that helps sharpen the contrast between adjacent areas of the visual scene. By comparing the signals from neighboring photoreceptors, horizontal cells can enhance the differences in light intensity and help create a more detailed and precise image. This information is then sent to bipolar cells, which relay it further to ganglion cells and ultimately to the brain for visual perception.

I'm sorry for any confusion, but "perches" is not a term commonly used in medical terminology. It is most often used to refer to a place where a bird or small animal perches, or in measurements of height (such as "perches above ground"). If you have any questions about a medical term or concept, I would be happy to help clarify!

I apologize for any confusion, but "bass" is not a medical term. It is a term that can have several meanings depending on the context. In music, "bass" refers to a low-pitched sound or instrument. In fishing and aquatic biology, "bass" refers to various species of freshwater fish.

If you are looking for a medical term related to the human body, perhaps you meant "brachial basal sulcus" or "basilar artery." If you can provide more context or clarify your question, I would be happy to help further!

The retina is the innermost, light-sensitive layer of tissue in the eye of many vertebrates and some cephalopods. It receives light that has been focused by the cornea and lens, converts it into neural signals, and sends these to the brain via the optic nerve. The retina contains several types of photoreceptor cells including rods (which handle vision in low light) and cones (which are active in bright light and are capable of color vision).

In medical terms, any pathological changes or diseases affecting the retinal structure and function can lead to visual impairment or blindness. Examples include age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinitis pigmentosa among others.

I'm sorry for any confusion, but "Goldfish" is not a term used in medical definitions. Goldfish are small domesticated fish that are often kept as pets. They belong to the family Cyprinidae and the genus Carassius. The most common species of goldfish is Carassius auratus. If you have any questions about goldfish or their care, I might be able to help with some general information, but for specific medical concerns, it would be best to consult a veterinarian.

I cannot provide a medical definition for "carps" as it is not a term used in medicine. The term "carp" refers to a type of freshwater fish that belongs to the family Cyprinidae. If you meant to ask about something else, please provide more context or clarify your question.

"Catfishes" is a term that refers to a group of ray-finned fish belonging to the order Siluriformes. However, in a medical or clinical context, "catfishing" has taken on a different meaning. It is a term used to describe the phenomenon of creating a false online identity to deceive someone, particularly in social media or dating websites. The person who creates the fake identity is called a "catfish." This behavior can have serious emotional and psychological consequences for those who are being deceived.

Retinal cone photoreceptor cells are specialized neurons located in the retina of the eye, responsible for visual phototransduction and color vision. They are one of the two types of photoreceptors, with the other being rods, which are more sensitive to low light levels. Cones are primarily responsible for high-acuity, color vision during daylight or bright-light conditions.

There are three types of cone cells, each containing different photopigments that absorb light at distinct wavelengths: short (S), medium (M), and long (L) wavelengths, which correspond to blue, green, and red light, respectively. The combination of signals from these three types of cones allows the human visual system to perceive a wide range of colors and discriminate between them. Cones are densely packed in the central region of the retina, known as the fovea, which provides the highest visual acuity.

I'm sorry for any confusion, but Quisqualic Acid is not a commonly used term in medicine or medical research. It is actually a type of neurotoxin that comes from certain plants and has been used in scientific research related to the nervous system and brain function. However, it is not something that would typically be discussed in a medical context for patient care or treatment.

Kainic acid is not a medical term per se, but it is a compound that has been widely used in scientific research, particularly in neuroscience. It is a type of excitatory amino acid that acts as an agonist at certain types of receptors in the brain, specifically the AMPA and kainate receptors.

Kainic acid is often used in research to study the effects of excitotoxicity, which is a process that occurs when nerve cells are exposed to excessive amounts of glutamate or other excitatory neurotransmitters, leading to cell damage or death. Kainic acid can induce seizures and other neurological symptoms in animals, making it a valuable tool for studying epilepsy and related disorders.

While kainic acid itself is not a medical treatment or diagnosis, understanding its effects on the brain has contributed to our knowledge of neurological diseases and potential targets for therapy.

Dopamine is a type of neurotransmitter, which is a chemical messenger that transmits signals in the brain and nervous system. It plays several important roles in the body, including:

* Regulation of movement and coordination
* Modulation of mood and motivation
* Control of the reward and pleasure centers of the brain
* Regulation of muscle tone
* Involvement in memory and attention

Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. It is released by neurons (nerve cells) and binds to specific receptors on other neurons, where it can either excite or inhibit their activity.

Abnormalities in dopamine signaling have been implicated in several neurological and psychiatric conditions, including Parkinson's disease, schizophrenia, and addiction.

Glutamates are the salt or ester forms of glutamic acid, which is a naturally occurring amino acid and the most abundant excitatory neurotransmitter in the central nervous system. Glutamate plays a crucial role in various brain functions, such as learning, memory, and cognition. However, excessive levels of glutamate can lead to neuronal damage or death, contributing to several neurological disorders, including stroke, epilepsy, and neurodegenerative diseases like Alzheimer's and Parkinson's.

Glutamates are also commonly found in food as a natural flavor enhancer, often listed under the name monosodium glutamate (MSG). While MSG has been extensively studied, its safety remains a topic of debate, with some individuals reporting adverse reactions after consuming foods containing this additive.

Glutamic acid is an alpha-amino acid, which is one of the 20 standard amino acids in the genetic code. The systematic name for this amino acid is (2S)-2-Aminopentanedioic acid. Its chemical formula is HO2CCH(NH2)CH2CH2CO2H.

Glutamic acid is a crucial excitatory neurotransmitter in the human brain, and it plays an essential role in learning and memory. It's also involved in the metabolism of sugars and amino acids, the synthesis of proteins, and the removal of waste nitrogen from the body.

Glutamic acid can be found in various foods such as meat, fish, beans, eggs, dairy products, and vegetables. In the human body, glutamic acid can be converted into gamma-aminobutyric acid (GABA), another important neurotransmitter that has a calming effect on the nervous system.

Membrane potential is the electrical potential difference across a cell membrane, typically for excitable cells such as nerve and muscle cells. It is the difference in electric charge between the inside and outside of a cell, created by the selective permeability of the cell membrane to different ions. The resting membrane potential of a typical animal cell is around -70 mV, with the interior being negative relative to the exterior. This potential is generated and maintained by the active transport of ions across the membrane, primarily through the action of the sodium-potassium pump. Membrane potentials play a crucial role in many physiological processes, including the transmission of nerve impulses and the contraction of muscle cells.

Horizontal gene transfer (HGT), also known as lateral gene transfer, is the movement of genetic material between organisms in a manner other than from parent to offspring (vertical gene transfer). In horizontal gene transfer, an organism can take up genetic material directly from its environment and incorporate it into its own genome. This process is common in bacteria and archaea, but has also been observed in eukaryotes including plants and animals.

Horizontal gene transfer can occur through several mechanisms, including:

1. Transformation: the uptake of free DNA from the environment by a cell.
2. Transduction: the transfer of genetic material between cells by a virus (bacteriophage).
3. Conjugation: the direct transfer of genetic material between two cells in physical contact, often facilitated by a conjugative plasmid or other mobile genetic element.

Horizontal gene transfer can play an important role in the evolution and adaptation of organisms, allowing them to acquire new traits and functions rapidly. It is also of concern in the context of genetically modified organisms (GMOs) and antibiotic resistance, as it can facilitate the spread of genes that confer resistance or other undesirable traits.

Photoreceptor cells are specialized neurons in the retina of the eye that convert light into electrical signals. These cells consist of two types: rods and cones. Rods are responsible for vision at low light levels and provide black-and-white, peripheral, and motion sensitivity. Cones are active at higher light levels and are capable of color discrimination and fine detail vision. Both types of photoreceptor cells contain light-sensitive pigments that undergo chemical changes when exposed to light, triggering a series of electrical signals that ultimately reach the brain and contribute to visual perception.

Cyprinidae is a family of fish that includes carps, minnows, and barbs. It is the largest family of freshwater fish, with over 2,400 species found worldwide, particularly in Asia and Europe. These fish are characterized by their lack of teeth on the roof of their mouths and have a single dorsal fin. Some members of this family are economically important as food fish or for aquarium trade.

I'm sorry for any confusion, but "turtles" is not a medical term. It refers to the group of reptiles that have a shell and include various species such as tortoises and terrapins. If you have any medical concerns or questions, I would be happy to try to help with those!

Dark adaptation is the process by which the eyes adjust to low levels of light. This process allows the eyes to become more sensitive to light and see better in the dark. It involves the dilation of the pupils, as well as chemical changes in the rods and cones (photoreceptor cells) of the retina. These changes allow the eye to detect even small amounts of light and improve visual acuity in low-light conditions. Dark adaptation typically takes several minutes to occur fully, but can be faster or slower depending on various factors such as age, prior exposure to light, and certain medical conditions. It is an important process for maintaining good vision in a variety of lighting conditions.

"Ambystoma" is a genus of salamanders, also known as the mole salamanders. These amphibians are characterized by their fossorial (burrowing) habits and typically have four limbs, a tail, and moist skin. They are found primarily in North America, with a few species in Asia and Europe. Some well-known members of this genus include the axolotl (A. mexicanum), which is famous for its ability to regenerate lost body parts, and the spotted salamander (A. maculatum). The name "Ambystoma" comes from the Greek words "amblys," meaning blunt, and "stoma," meaning mouth, in reference to the wide, blunt snout of these animals.

Ocular adaptation is the ability of the eye to adjust and accommodate to changes in visual input and lighting conditions. This process allows the eye to maintain a clear and focused image over a range of different environments and light levels. There are several types of ocular adaptation, including:

1. Light Adaptation: This refers to the eye's ability to adjust to different levels of illumination. When moving from a dark environment to a bright one, the pupils constrict to let in less light, and the sensitivity of the retina decreases. Conversely, when moving from a bright environment to a dark one, the pupils dilate to let in more light, and the sensitivity of the retina increases.
2. Dark Adaptation: This is the process by which the eye adjusts to low light conditions. It involves the dilation of the pupils and an increase in the sensitivity of the rods (specialised cells in the retina that are responsible for vision in low light conditions). Dark adaptation can take several minutes to occur fully.
3. Color Adaptation: This refers to the eye's ability to adjust to changes in the color temperature of light sources. For example, when moving from a room lit by incandescent light to one lit by fluorescent light, the eye may need to adjust its perception of colors to maintain accurate color vision.
4. Accommodation: This is the process by which the eye changes focus from distant to near objects. The lens of the eye changes shape to bend the light rays entering the eye and bring them into sharp focus on the retina.

Overall, ocular adaptation is an essential function that allows us to see clearly and accurately in a wide range of environments and lighting conditions.

Ictaluridae is not a term that has a medical definition, as it pertains to the field of biology and zoology rather than medicine. Ictaluridae is the family of freshwater fishes commonly known as "North American catfishes." These fishes are characterized by their barbels, which resemble cats' whiskers, and their armored bodies.

However, in a medical context, certain types of Ictaluridae may be mentioned in relation to food safety or allergies. For example, if a patient has an allergy to fish, they may need to avoid consuming Ictaluridae species such as channel catfish or blue catfish. Similarly, if there is a concern about foodborne illness, certain types of Ictaluridae may be implicated in outbreaks of diseases such as scombrotoxin poisoning.

Therefore, while "Ictaluridae" itself does not have a medical definition, it is a term that may be used in medicine in relation to food safety or allergies.

Photic stimulation is a medical term that refers to the exposure of the eyes to light, specifically repetitive pulses of light, which is used as a method in various research and clinical settings. In neuroscience, it's often used in studies related to vision, circadian rhythms, and brain function.

In a clinical context, photic stimulation is sometimes used in the diagnosis of certain medical conditions such as seizure disorders (like epilepsy). By observing the response of the brain to this light stimulus, doctors can gain valuable insights into the functioning of the brain and the presence of any neurological disorders.

However, it's important to note that photic stimulation should be conducted under the supervision of a trained healthcare professional, as improper use can potentially trigger seizures in individuals who are susceptible to them.

Retinal bipolar cells are a type of neuron located in the inner nuclear layer of the retina, an light-sensitive tissue that lines the interior of the eye. These cells play a crucial role in the visual system by transmitting visual signals from photoreceptors (rods and cones) to ganglion cells, which then relay this information to the brain via the optic nerve.

Bipolar cells have two processes or "arms" that connect to either photoreceptors or ganglion cells: one process receives input from photoreceptors and the other transmits output to ganglion cells. They are called "bipolar" because of this dual connection. These cells can be classified into different types based on their morphology, neurotransmitter usage, and synaptic connections with photoreceptors and ganglion cells.

There are two primary types of retinal bipolar cells: rod bipolar cells and cone bipolar cells. Rod bipolar cells mainly transmit signals from rod photoreceptors, which are responsible for low-light vision, while cone bipolar cells connect to cone photoreceptors that handle color vision and high visual acuity in bright light conditions.

Retinal bipolar cells help process and encode visual information based on contrast, spatial patterns, and temporal changes in light intensity. Their output contributes significantly to the formation of visual perceptions such as brightness, contrast, and motion detection. Dysfunction or damage to retinal bipolar cells can lead to various visual impairments and diseases, including some forms of vision loss.

"Retinal Horizontal Cells" by people in this website by year, and whether "Retinal Horizontal Cells" was a major or minor topic ... "Retinal Horizontal Cells" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... as well as other horizontal cells. The horizontal cells modulate the sensory signal. ... Retinal Horizontal Cells*Retinal Horizontal Cells. *Horizontal Cells, Retinal. *Cell, Retinal Horizontal ...
Native responses of the GABAC receptor type occur in retinal bipolar or horizontal cells across vertebrate species. GABAС ... Qian H, Dowling JE (January 1993). "Novel GABA responses from rod-driven retinal horizontal cells". Nature. 361 (6408): 162-4. ... Feigenspan A, Wässle H, Bormann J (January 1993). "Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells". ... After this period of development, a chloride pump is upregulated and inserted into the cell membrane, pumping Cl− ions into the ...
Qian H, Dowling JE (1993) Novel GABA responses from rod-driven retinal horizontal cells. Nature 361: 162-164. ... Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar Purkinje cells: a Lugaro cell to Purkinje cell ... Feigenspan A, Wassle H, Bormann J (1993) Pharmacology of GABA receptor Cl-channels in rat retinal bipolar cells. Nature 361: ... Optogenetics reveals roles for supporting cells in force transmission to and from outer hair cells in the mouse cochlea ...
Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes ... Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes ... Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes ... Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes ...
... a green-sensitive photoreceptive molecule present in zebrafish deep brain and retinal horizontal cells. J Neurosci 20:2845-2851 ... opsin-immunoreactive cells in the diencephalon and α-transducin-immunoreactive cells in the telencephalon were observed in ... von Frisch (1911) examined the effect of direct illumination into the brain on the body color and proposed that cells of the ... By in situ hybridization histochemistry, the rhodopsin mRNA was detected in the rod photoreceptor cells in the retina. However ...
... mice to blue light not only induces cone cell death but also disrupts the inner blood-retinal barrier. Macular edema in humans ... This was accompanied by retinal swelling and the appearance of cystoid spaces in both inner and ONLs of R91W;Nrl−/− mice ... Recently, we generated R91W;Nrl−/− double-mutant mice, which display a well-ordered all-cone retina with normal retinal ... mice led to additional cell death detected within the inner nuclear layer. Microglia/macrophage infiltration at the site of ...
Retinal neurons fall into one of five classes-photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion ... They also identified a type of retinal cell that had not been seen before. ... By mapping all the neurons in this 117-by-80-micrometer patch of retinal tissue, the researchers were able to classify most of ... Diagramming the wiring of retinal neurons is a first step toward mapping the brain. ...
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development. Edqvist, P.H., ... which have also been translocated in a ventricular direction were positive for the horizontal cell markers Lim1 and Prox1 [14]. ... Assignment of LHX1 to human chromosome bands 17q11.2--,q12 by use of radiation hybrid mapping and somatic cell hybridization. ... Assignment of LHX1 to human chromosome bands 17q11.2--,q12 by use of radiation hybrid mapping and somatic cell hybridization [8 ...
2006) Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells ... N-cadherin also promotes dendritic arborization in retinal ganglia (Riehl et al., 1996) and horizontal cells (Tanabe et al., ... 1996) Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo Neuron 17:837-848. ... 2014) Type II cadherins guide assembly of a direction-selective retinal circuit Cell 158:793-807. ...
Visual acuity, studied in hatchlings, is highest in a horizontal band with retinal cells packed about twice as densely as ... The red-eared slider has an exceptional seven types of color-detecting cells in its eyes.[37]. Turtles make use of vision to ... The retinas light-sensitive cells include both rods for vision in low light, and cones with three different photopigments for ... A freshwater turtle, the red-eared slider, has an exceptional seven types of cone cell.[37][38][39] ...
Targeted Deletion of Vesicular GABA Transporter from Retinal Horizontal Cells Eliminates Feedback Modulation of Photoreceptor ... Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development. Frontiers in Cell ... Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming ... Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model. Frontiers in ...
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage ... Cell Cycle Life Science Poster. Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA ... Cell Cycle and DNA Damage product guide. Our Cell Cycle and DNA Damage Research Guide highlights over 750 products for cell ... Cell Cycle & DNA Damage Repair Poster. In normal cells, each stage of the cell cycle is tightly regulated, however in cancer ...
... cell bodies of bipolar, amacrine and horizontal cells) and in the retinal pigment epithelium. These cell classes also express β ... Retinal Biomarkers. Retinal Nerve Fiber Layer and Optic Nerve. The first histological evidence for retinal abnormalities in AD ... Studies in animal models confirmed that APP is expressed by retinal ganglion cells, in the inner nuclear layer of the retina ( ... 2015). Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive ...
... horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. Based on the ... cells (HCs), BCs, amacrine cells (ACs), and retinal ganglion cells. New evidence suggests that mouse MGCs do not significantly ... Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell ... Retinal BCs die first in a model of chronic hypoglycemia [24], and retinal ganglion cells die faster than photoreceptors after ...
Ultrastructural analysis showed that LTE damaged mitochondria in retinal ganglion cells and in the inner plexiform layer. Thus ... Retinal cryosections were immunolabeled for glial fibrillary acid protein (GFAP) and with terminal deoxynucleotidyl transferase ... was immunolabelled on retinal whole-mounts. To count and measure Opn4-positive ipRGC somas and dendrites (including Sholl ... increased retinal GFAP immunoreactivity (p , 0.001, p = 0.002, respectively), and caused outer segment vesiculation and outer ...
Transmembrane protein 237 localizes to retinal photoreceptor outer segments and to the outer plexiform layers horizontal cells ... Autologous induced stem-cell-derived retinal cells for macular degeneration. N Engl J Med. 2017; 376:1038-1046. ... IQCB1 has been reported to localize to retinal photoreceptors and to primary epithelial cells cilia.82 ... Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. Nat ...
Retinal Horizontal Cells. NEURONS in the inner nuclear layer of the RETINA that synapse with both the RETINAL PHOTORECEPTOR ... CELLS and the RETINAL BIPOLAR CELLS, as well as other horizontal cells. The horizontal cells modulate the sensory signal.. ... Low levels of Otx2 impair ... a) Cell clusters visualized using t- ... 3 photoreceptor, 2 horizontal cell, 12 bipolar cell, 7 ... Cells1. *In cultured cells treated with 1, 25-(OH) 2 D 3 for 72 h, calbindin-D 28K induction was greater in cells from adult ...
A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum. Kato, M., Sugiyama, T., ... KCNJ13 gene deletion impairs cell alignment and phagocytosis in retinal pigment epithelium derived from human-induced ... Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt ... Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells ...
Proton transport mechanism of retinal horizontal cells mediating pH changes in the synaptic cleft of cone photoreceptor ... isolated cells / カテコラミン / ガンマアミノ酪酸 / 神経伝達物質 / カメ / vision / 伝達物質 / 視覚 / pH-sensitive dye / horizontal cell / lateral inhibition ... Protons work as negative feedback mediators extruded via V-ATPase from horizontal cells to cone photoreceptors cells in fish ... Protons work as negative feedback mediators extruded via V-ATPase from horizontal cells to cone photoreceptors cells in fish ...
The electron micrograph in the top panel shows two invaginating synapses between cone and horizontal cells in the outer p... ... cell surface Confocal image of the developing eye of a chick embryo. The dark region in the centre is the where the surface ... Figures 323 & 324 from Chapter 13 (Cilia and Flagella) of The Cell by Don W. Fawcett M.D. The outer segments of the rods and ...
Onecut1 is essential for horizontal cell genesis and retinal integrity. J Neurosci. 2013 Aug 07; 33(32):13053-65, 13065a. ... The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. ... Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neurons presynaptic terminal ... Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid- ...
Retinal horizontal cells express a chemogenetic channel after systemic AAV infection. Cell bodies of horizontal cells are ... developed a method to control the activity of horizontal cells. Horizontal cells are a retinal circuit element that provides ... in the entire horizontal cell network allowed us to reversibly and efficiently perturb the activity of all horizontal cells ... In addition, the team found that the model made five further predictions about the role of horizontal cells, which they had ...
Mueller glial cells, bipolar cells, horizontal cells, and ganglion cells in the retina.[32] Dopamine modulates the receptive ... As the inner retinal layer (IRL) [internal limiting membrane, nerve fiber layer, ganglion cell layer, and inner plexiform ... Retinal pathology in Alzheimers disease. I. Ganglion cell loss in foveal/parafoveal retina. Neurobiology of aging. May-Jun ... Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol [Internet]. 2016 Jan [cited 2019 Aug 14];79(1):90-109. ...
... to be involved in the pathogenesis of retinal lesions is abnormalities in the internal limiting membrane formed by Müller cells ... Fukutin, responsible for FCMD, and α-DG are expressed in Müller cells. Moreover, fukutin may be involved in synaptic functions ... of retinal neurons through the glycosylation of α-DG. In this chapter, ocular lesions of fetal and child FCMD patients are ... Clinical ocular manifestations are myopia, strabismus, retinal detachment, and so on. Since the retina has a structure partly ...
Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell ... Horizontal-cell feedback modulation of horizontal cells. Horizontal-cell modulation of transmitter release from cones serves to ... horizontal-cell types accumulate GABA (51). A likely target of horizontal-cell GABA is other horizontal cells. Kamermans ... Horizontal-cell GABA could still have a feed-forward action directly upon bipolar cell dendrites or other horizontal-cell ...
... horizontal cells, bipolar cells,Müller glia, amacrine cells and ganglion cells(Fig. 4B). The Cre-negative mGFP+ clones were ... bipolar cells, horizontal cells, amacrine cells and Müller Glia) and in the GCL (ganglion and amacrine cells)(Fig. 4D). In ... horizontal cells, bipolar cells, amacrine cells and ganglion cells) and one glial type (Müller glia) organized in a ... Ganglion cells, cone photoreceptors, horizontal cells and amacrine cells were produced and initiated differentiation. However, ...
This leads to activation of the next line of cells (bipolar, horizontal cells and retinal ganglion cells). ... The most sensitive of retinal ganglion cells need ~0.04% of rhodopsin molecules per rod cell to be activated (Takeshita et al ... b) Absolute threshold of On and Off retinal ganglion cells. Both On and Off RGCs carry rich information about the weakest light ... So, I can make a reliable guess that you cannot actually "see" a photon although one of the retinal photoreceptor cells can ...
... we discover that retinal horizontal cells express the leucine-rich repeat domain cell adhesion molecule AMIGO1. Horizontal ... Here, we identify a cell surface protein, AMIGO1, that selectively promotes axon growth of horizontal cells, a retinal ... By contrast, horizontal cell dendrites and synapse formation of horizontal cell axons and dendrites are unaffected by AMIGO1 ... AMIGO1 selectively expands the size of horizontal cell axons. When Amigo1 is deleted in all or individual horizontal cells of ...

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