A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night blindness and progressive contraction of the visual field.
Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.
Recording of electric potentials in the retina after stimulation by light.
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
A rare degenerative inherited eye disease that appears at birth or in the first few months of life that results in a loss of vision. Not to be confused with LEBER HEREDITARY OPTIC NEUROPATHY, the disease is thought to be caused by abnormal development of PHOTORECEPTOR CELLS in the RETINA, or by the extremely premature degeneration of retinal cells.
A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age.
The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)
Type III intermediate filament proteins expressed mainly in neurons of the peripheral and CENTRAL NERVOUS SYSTEMS. Peripherins are implicated in neurite elongation during development and axonal regeneration after injury.
Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.
The blood vessels which supply and drain the RETINA.
Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2.
Devices for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth. (UMDNS, 1999)
Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.
A group of disorders involving predominantly the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the RETINA; RETINAL PIGMENT EPITHELIUM; BRUCH MEMBRANE; CHOROID; or a combination of these tissues.
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.
The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
Examination of the interior of the eye with an ophthalmoscope.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
The macroglial cells of EPENDYMA. They are characterized by bipolar cell body shape and processes that contact BASAL LAMINA around blood vessels and/or the PIA MATER and the CEREBRAL VENTRICLES.
The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; OPTIC NERVE DISEASES; OPTIC CHIASM diseases; or BRAIN DISEASES affecting the VISUAL PATHWAYS or OCCIPITAL LOBE.
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Nerve cells of the RETINA in the pathway of transmitting light signals to the CENTRAL NERVOUS SYSTEM. They include the outer layer of PHOTORECEPTOR CELLS, the intermediate layer of RETINAL BIPOLAR CELLS and AMACRINE CELLS, and the internal layer of RETINAL GANGLION CELLS.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
A group of rare, idiopathic, congenital retinal vascular anomalies affecting the retinal capillaries. It is characterized by dilation and tortuosity of retinal vessels and formation of multiple aneurysms, with different degrees of leakage and exudates emanating from the blood vessels.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.
An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)
A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.
Defects of color vision are mainly hereditary traits but can be secondary to acquired or developmental abnormalities in the CONES (RETINA). Severity of hereditary defects of color vision depends on the degree of mutation of the ROD OPSINS genes (on X CHROMOSOME and CHROMOSOME 3) that code the photopigments for red, green and blue.
Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.
Neurons of the innermost layer of the retina, the internal plexiform layer. They are of variable sizes and shapes, and their axons project via the OPTIC NERVE to the brain. A small subset of these cells act as photoreceptors with projections to the SUPRACHIASMATIC NUCLEUS, the center for regulating CIRCADIAN RHYTHM.
Method of measuring and mapping the scope of vision, from central to peripheral of each eye.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
The administration of substances into the eye with a hypodermic syringe.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).
Genes that influence the PHENOTYPE only in the homozygous state.
Biochemical identification of mutational changes in a nucleotide sequence.
The total area or space visible in a person's peripheral vision with the eye looking straightforward.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Diseases affecting the eye.
A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. Low vision generally refers to visual disorders that are caused by diseases that cannot be corrected by refraction (e.g., MACULAR DEGENERATION; RETINITIS PIGMENTOSA; DIABETIC RETINOPATHY, etc.).
Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Method of making images on a sensitized surface by exposure to light or other radiant energy.
An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Transport proteins that carry specific substances in the blood or across cell membranes.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Introduction of substances into the body using a needle and syringe.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Any method used for determining the location of and relative distances between genes on a chromosome.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light. (1/1813)

The photopathology of retinal lesions produced by extended exposure (1000 sec) to low corneal power levels (62 microW) of blue light (441 nm) was investigated by light microscopy in 20 rhesus eyes over an interval ranging from 1 hr to 90 days after exposure. Results indicate a nonthermal type of photochemical lesion originating in the retinal pigment epithelium and leading to a histological response with hypopigmentation which requires 48 hr to appear. This type of lesion helps to explain solar retinitis and eclipse blindness and has significance for aging and degenerative changes in the retina.  (+info)

Pigment epithelial windows and drusen: an animal model. (2/1813)

Aging rhesus monkeys, both controls and those undergoing long-term administration of investigational oral contraceptive steroids, developed widespread hyperfluorescent dots at the posterior pole. The dots were considered to represent drusen. Histologic (including electron microscopic) study showed the "drusen" in some of the animals to be almost exclusively pigment epithelial windows produced by a lipoidal degeneration of the pigment epithelial cells. The experiment provided a fortuitous model for direct correlation of clinical and histologic observations of myriad uniform, tiny, depigmented, hyperfluorescent, nonleaking spots at the level of the retinal pigment epithelium.  (+info)

Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. (3/1813)

PURPOSE: Accumulated evidence has shown that apoptosis and necrosis contribute to neuronal death after ischemia. The present study was performed to study the temporal and spatial patterns of neuronal necrosis and apoptosis after ischemia in retina and to outline mechanisms underlying necrosis and apoptosis. METHODS: Retinal ischemia was induced by increasing intraocular pressure to a range of 160 mm Hg to 180 mm Hg for 90 minutes in adult rats. The patterns of neuronal cell death were determined using light and electron microscopy and were visualized by TdT-dUTP nick-end labeling (TUNEL). The mRNA expression profile of p53 was examined using reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization histochemistry. Immunohistochemistry was performed using anti-p53, anti-microtubule associated protein-2, and anti-glial fibrillary acidic protein antibodies. RESULTS: Within 4 hours after ischemia, neurons in the inner nuclear cell layer (INL) and ganglion cell layer (GCL) underwent marked necrosis, made apparent by swelling of the cell body and mitochondria, early fenestration of the plasma membrane, and irregularly scattered condensation of nuclear chromatin. After 3 days, the INL and GCL neurons showed further degeneration through apoptosis marked by cell body shrinkage, aggregation, and condensation of nuclear chromatin. Apoptotic neurons were also observed sparsely in the outer nuclear cell layer. Intravitreal injections of MK-801 prevented early neuronal degeneration after ischemia. Of note, mRNA and protein levels of p53, the tumor suppressor gene known to induce apoptosis, were increased in the retinal areas undergoing apoptosis 1 to 3 days after ischemic injury. CONCLUSIONS: Ischemia produces the N-methyl-D-aspartate-mediated necrosis and slowly evolving apoptosis of neurons in the retina. The latter may depend on the expression of the p53 proapoptosis gene.  (+info)

Idiopathic central serous chorioretinopathy. (4/1813)

Idiopathic central serous chorioretinopathy (ICSC) is usually seen in young males with Type A personality. Clinical evaluation of the macula with fundoscopy and biomicroscopy, coupled with fluorescein angiography establishes the diagnosis. Indocyanine green angiographic studies have reinformed that the basic pathology lies in choriocapillaries and retinal pigment epithelium. Most of the ICSC resolve completely in four months, and some of them could resolve early with direct photocoagulation of the leaking site. Oral steroids have no role, and could even cause an adverse reaction.  (+info)

Rapid pneumatic and Mackey-Marg applanation tonometry to evaluate the postural effect on intraocular pressure. (5/1813)

A postural study was conducted in three separate groups of subjects. The first group comprised 20 women volunteers with an average age of 20-75 years. In this group, the study was conducted by the pneumatonograph only. Mean pressure recorded was 15-65 +/- 0-25 mmHg and there was an average rise of 1-4 mmHg in supine posture. Groups 2 and 3 comprised 151 non-glaucomatous and 108 glaucomatous eyes respectively in the age range of 30 to 85 years. In these two groups, the study was conducted using the PTG and the Mackay-Marg tonometer. Clinical evaluation of the Mackay-Marg with the PTG gave significant correlation, with mean Mackay-Marg readings being 1-13 mmHg higher. The intraocular pressure when changing from seated to the supine position increased on average by 2-71 and 4-04 mmHg, respectively in Groups 2 and 3 and by 2-51 and 3-72 mmHg by Vackay-Marg, suggesting a higher change in glaucomatous subjects. Pressure on resumption of sitting was found to be lower than the initial pressure. Postural change also showed some direct relationship with age in non-glaucomatous subjects.  (+info)

Chronic retinal vein occlusion in glaucoma. (6/1813)

Asymptomatic chronic retinal vein occlusion that occurs in chronic simple glaucoma is described. The condition is characterized by marked elevation of retinal vein pressure with collateral vessels and vein loops at the optic disc in cases of central vein occlusion, or retinal veno-venous anastomoses along a horizontal line temporal and nasal to the disc in hemisphere vein occlusion. No patient had visible arterial changes, capillary closure, fluorescein leakage, or haemorrhages. The vein occlusion was not limited to "end stage" glaucoma. The role of increased intraocular pressure and glaucomatous enlargement of the optic cup with retinal vein distortion in the pathogenesis of the condition was stressed. Follow-up of these patients revealed persistence of the retinal vein occlusion shown by elevated retinal vein pressures. This would reduce effective perfusion of the inner retina and optic disc and may affect the long-term visual prognosis.  (+info)

Apoptosis and caspases after ischemia-reperfusion injury in rat retina. (7/1813)

PURPOSE: Extensive cell loss in the retinal ganglion cell layer (RGCL) and the inner nuclear layer (INL) was noted in a rat model of retinal ischemia-reperfusion injury by transient elevated intraocular pressure (IOP). The possible involvement of apoptosis and caspases was examined in this model of neuronal loss. METHODS: Transient elevated IOP was induced in albino Lewis rats through the insertion of a needle into the anterior chamber connected to a saline column. Elevated IOP at 110 mm Hg was maintained for 60 minutes. Groups of animals were euthanatized at various times after reperfusion, and their retinas were evaluated by morphology, agarose gel electrophoresis of DNA, in situ terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL), immunohistochemistry of caspases II (ICH1) and III (CPP32), and morphometry. YVAD.CMK, a tetrapeptide inhibitor of caspases, was used to examine the involvement of caspases. RESULTS: A marked ladder pattern in retinal DNA gel analysis, typical of internucleosomal DNA fragmentation and characteristic of apoptosis, was present 12 and 18 hours after reperfusion. Labeling of nuclei in the RGCL and the inner nuclear layer (INL) by TUNEL was noted between 8 and 18 hours after reperfusion. Histologic and ultrastructural features typical of apoptosis were also observed in the inner retina after ischemia. YVAD.CMK administered during the ischemic period inhibited apoptotic fragmentation of retinal DNA and ameliorated the tissue damage. When administered intravitreally 0, 2, or 4 hours after reperfusion, YVAD.CMK was also effective in preserving the inner retina but had no significant effect when administered 6 or 8 hours after reperfusion. The inner retina showed transient elevated immunoreactivity of caspases II and III 4 and 8 hours after reperfusion. CONCLUSIONS: Retinal ischemia-reperfusion after transient elevated IOP induced apoptosis of cells in the retinal ganglion cell layer and the INL. Caspases may have a pivotal role in the early events of the apoptotic pathway(s). Rescue by using anti-apoptotic agents after ischemia-reperfusion is feasible.  (+info)

Retinopathy of prematurity-mimicking retinopathy in full-term babies. (8/1813)

The purpose of this study was to analyze the fundus findings and associated abnormalities in full-term babies with retinopathy of prematurity (ROP)-mimicking retinopathy. In twenty-seven such babies suffering from this condition, retinal findings were retrospectively analyzed. These babies were not premature and had not required supplementary oxygen; there was no family history of the disease, and no known causes. Bilaterality and severity of retinopathy were compared between groups with associated systemic abnormalities and those without. Forty eyes in twenty-seven full-term babies had abnormal retinal findings; dragged retina accounted for 42.5%, and falciform retinal fold for 47.5%, and retrolental membrane for 10%. Nine babies had associated brain abnormalities, and in these, severe bilateral retinopathy was more likely to occur than in those without abnormalities. These results suggest that if full-term babies have associated abnormalities of the brain, the presence of retinopathy should be ascertained postnatally by cautious examination of the retina.  (+info)

H30.143 is a billable diagnosis code used to specify a medical diagnosis of acute posterior multifocal placoid pigment epitheliopathy, bilateral. Code valid for the fiscal year 2021
Symptoms of the following disorders can be similar to those of acute posterior multifocal placoid pigment epitheliopathy. Comparison may be useful for a differential diagnosis:. Diffuse unilateral subacute neuroretinitis (DUSN) is a progressive parasitic disease affecting the outer retina and retinal pigment epithelium (RPE). This syndrome is primarily unilateral, although bilateral cases have occurred. Examination of the eye shows visual loss, vitreous cells, optic disc inflammation and leakage, and transient, but recurrent, crops of gray-white outer retinal lesions.. Stationary or migrating parasitic worms (nematodes) have been identified deep in the retina or in the subretinal space. Later in the course of the disease, slowly progressive RPE changes and optic atrophy may be observed, as well as narrowing of the retinal vessels.. Multifocal choroidopathy syndromes are a group of rare disorders involving a major pathological change at or near the level of the retinal pigment epithelium (RPE) ...
TY - JOUR. T1 - Purtschers retinopathy associated with acute pancreatitis. AU - Hamp, Ania M.. AU - Chu, Edward. AU - Slagle, William S.. AU - Hamp, Robert C.. AU - Joy, Jeffrey T.. AU - Morris, Robert W.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/2. Y1 - 2014/2. N2 - PURPOSE: Purtschers retinopathy is a rare condition that is associated with complement-activating systemic diseases such as acute pancreatitis. After pancreatic injury or inflammation, proteases such as trypsin activate the complement system and can potentially cause coagulation and leukoembolization of retinal precapillary arterioles. Specifically, intermediate-sized emboli are sufficiently small enough to pass through larger arteries yet large enough to remain lodged in precapillary arterioles and cause the clinical appearance of Purtschers retinopathy. This pathology may present with optic nerve edema, impaired visual acuity, visual field loss, as well as retinal findings such as ...
Purpose : Split Spectrum Amplitude Decorrelation Angiography (SSADA) based Optical Coherence Tomography Angiography (OCTA) evaluation of Acute Multifocal Placoid Pigment Epitheliopathy (AMPPE). Methods : Retrospective review of SSADA based OCTA, SD-OCT and FA on patients with AMPPE, and to observe the choroidal vascular changes over the clinical course of this disease. Results : 2 patients with AMPPE were evaluated using OCTA. During the acute phase, OCTA detected no blood flow in the choriocapillaris corresponding to retinal placoid lesions on clinical exam, but there was surrounding increased flow. In addition, there were some hyporeflective areas in the RPE and outer retina corresponding to the retinal placoid lesions. There was no significant vascular flow changes in the superficial and deep retina. In the resolution stage of this disease, blood flow resumed and a pigment shadowing effect was noted. Conclusions : OCTA showed a significant deprivation of choriocapillaris blood flow in the ...
Cotton wool spots are an abnormal finding on funduscopic exam of the retina of the eye. They appear as fluffy white patches on the retina. They are caused by damage to nerve fibers and are a result of accumulations of axoplasmic material within the nerve fiber layer. There is reduced axonal transport (and hence backlog and accumulation of intracellular products) within the nerves because of the ischemia. This then causes the nerve fibers to be damaged by swelling in the surface layer of the retina. A 1981 analysis concluded that in most instances, cotton-wool spots do not represent the whole area of ischaemic inner retina but merely reflect the obstruction of axoplasmic flow in axons crossing into much larger ischaemic areas.[1] Associated findings include microvascular infarcts and hemorrhages. The appearance of cotton wool spots may decrease over time. Abundant cotton wool spots are seen in Malignant hypertension.. Diabetes and hypertension are the two most common diseases that cause these ...
Aims: To study the incidence, systemic associations, presenting features and natural history of Purtschers retinopathy in the UK and Ireland.. Methods: Cases were collected prospectively by active surveillance through the British Ophthalmological Surveillance Unit. Clinical details were obtained using an incident questionnaire, with follow-up at 1 and 6 months.. Results: Clinical details were obtained for 15 cases over 12 months. These were associated with road traffic accidents in 6 cases, chest compression in 6 cases and acute pancreatitis in 3 cases. All cases were symptomatic and presented with loss of visual acuity, visual field or a combination. Bilateral involvement was noted in 9 cases. The acute retinal signs of cotton wool spots, retinal haemorrhage and Purtscher flecken cleared within 1 month in 26% of eyes and within 6 months in all eyes. The most common chronic signs were optic disc pallor and atrophy of the retinal pigment epithelium. Without treatment, 50% of eyes improved by at ...
The U.S Food and Drug Administration in October 2017 revealed their plans to recommend gene therapy as a way to treat inherited retinal diseases. These diseases usually cause a gradual loss of sight that eventually leads to total blindness.. What are Inherited Retinal Diseases (IRDs)?. Inherited retinal diseases (IRDs) are rare eye problems that are caused by mutations that occur in the RPE65 gene. These types of gene mutations are hereditary and responsible for specific conditions that include Lebers congenital amaurosis and some forms of retinitis pigmentosa. Gene therapy can be used to treat these eye disorders.. How gene therapy can treat inherited retinal diseases. People suffering from various types of inherited retinal diseases either have genes that dont work, or are missing. Gene therapy can be used to treat these diseases by adding new genes to their cells to replace the missing or dysfunctional ones.. Usually, they use a specific prepared virus that introduces its own different ...
Cotton wool spots are yellow or white spots on the surface of the retina when the retina doesnt get enough blood. The effects of...
54-year-old woman was seen in the office on 3/25/2011. She was diagnosed as HIV positive in 1993. Her CD4 count is currently less than 50 and she was hospitalized for pneumocystis carinii pneumonia back in November of 2010. Earlier this month, on March 3rd, she had an episode where she felt strange. She dropped a smoothie and had slurred speech for about ten minutes. Her symptoms completely cleared and it was thought she had a transient ischemic attack. Since then she has had MRI and CT scans, both of which were normal, but she has noticed just for the last few weeks a few blind spots in the paracentral vision. Predominantly out of her right eye when she closes her left eye, she sees a few temporal blind spots. VISUAL ACUITY: Her vision is 20/25 in each eye. IOP: OD 11, OS 12. SLIT LAMP EXAM: Normal with clear lenses. EXTENDED OPHTHALMOSCOPY: OD: Vertical C/D ratio is 0.5. There is no posterior vitreous separation. There are cotton-wool spots predominantly superior to the optic nerve and ...
Purpose : Inherited retinal diseases (IRDs) may be caused by variations in genes affecting the connecting cilium of photoreceptor cells and the intraflagellar transport summarized as ciliopathies. CEP290 is frequently mutated in non-syndromic, but also syndromic IRDs. In preparation for clinical treatment trials detailed phenotypic work-up including longitudinal follow-up is mandatory. Methods : We performed genotype-phenotype correlations in 29 patients with biallelic mutations in CEP290. The study was approved by the IRB of the medical faculty, JLU Giessen. The patients received a comprehensive clinical examination including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) recording, and electrophysiology whenever possible. Results : We compiled data from a median age at first visit of 0.7 y and a median follow-up period of 5.1 y (range 6 m to 25.7 y). The oldest patient was 84 y at last visit ...
Hi, I donated platelets for the first time on Monday, and on Tuesday I noticed this crescent moon shadow in my left eye. I went to the opthamologist today, and she determined I had a cotton wool s...
So now that the biggest nature-themed event of 2017 is finished, we can all throw our rad NASA certified eclipse goggles into a drawer until 2024, when the next eclipse is due, and move on with our lives. Correct?. Wrong.. Nature is a cruel mistress, and if we think we can get away with a little entertainment and not pay the price, we have another thing coming to us. Over the next several days, there may be droves of patients presenting with the chief complaint of: Help, I looked at the eclipse through [a roll of toilet paper, binoculars, used film, four sets of sunglasses taped sequentially together] and now my vision is blurry, my eyes hurt, and there is a black spot in my visual field.. So, what is Solar Retinopathy? Also known as Photic Retinopathy, Foveomacular Retinitis, Solar Retinitis, or Eclipse Retinopathy, this is a disease process that has been described even by the Greeks during the Hellenic period, afflicting astronomers and sun-gazers.. This process is not a direct thermal burn, ...
In simple terms, genes are like recipes for making proteins. All the cells in our bodies read genetic information so they can make the critical proteins necessary to stay healthy and function properly. If there is a mistake in a gene - that is, a misspelling - a protein might not be made correctly and cells in the retina might degenerate and cause vision loss.. These misspellings are called mutations, and just like a mistake in a recipe, some mutations are more devastating than others. For example, when baking a cake, lets say there is an error in the recipe. It incorrectly calls for a quarter cup of sugar, when the right amount is a half of a cup. The cake may not taste great, but it is still edible. But lets say the instruction for adding flour is omitted entirely. Then the cake will be a complete failure and go uneaten.. Well, the same concept applies to genetic mutations in inherited retinal diseases. Some mutations can lead to devastating vision loss while others cause less severe, ...
The gene therapy technology already exists to treat most inherited retinal disease. The current challenge is to drive down the costs of implementing the technology.
Professor Anthony Moore, wrote an interesting article on gene testing for inherited retinal disease (IRD) in Ophthalmology, a scientific journal for eyes.
In this post, Professor Michaelides imagines a future of better retinal disease diagnostics and treatments, especially for inherited retinal diseases.
This live course is designed to provide clinicians with current information and strategies for the diagnosis and treatment of pediatric and hereditary retinal diseases. It focuses on the following topics: survey of pediatric retinal diseases and the use of gene therapy in hereditary retinal diseases. The first half of the course uses case scenarios to provide in depth knowledge of pediatric retinal diseases. It specifically addresses how to create a differential diagnosis for leukorcoria, the importance of ruling out retinoblastoma, a better understanding of retinovascular/exudative causes of pediatric retinal disease, a better understanding of hereditary vitreoretinal disorders in the pediatric population, how to differentiate congenital optic nerve head disorders and sequelae, and traumatic ocular injuries in pediatric patients. The second half of the course provides updates on current gene therapies for the treatment of hereditary retinal diseases with the potential to restore vision or slow ...
Also, exhibits, which in a medical negligence case typically involve medical records, may also be augmentin purchase into evidence and go with the jury into the jury room. L. Bruhn, W. Cotton wool spots and hemorrhages are features of retinal ischemia.
GAINESVILLE, Fla. and CAMBRIDGE, Mass. and COLUMBIA, Md., Aug. 15, 2017 (GLOBE NEWSWIRE) -- Applied Genetics Technology Corporation (NASDAQ:AGTC), a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapies for the treatment of rare diseases, and the Foundation Fighting Blindness (FFB) announced today a partnership agreement to support the organizations shared mission to advance gene therapy research to treat inherited retinal diseases.. We are grateful to AGTC for its continued support of the Foundation, says Valerie Navy-Daniels, FFBs chief development officer. AGTCs support will allow us to bring information about the advancements in treating inherited retinal diseases to more people and in doing so helps us get closer to our goal of bringing hope to people affected by these blinding conditions.. Under the terms of the agreement, AGTC will provide grant funding to support the Foundations My Retina Tracker® registry as well as a ...
Leaders in the field meet to educate physicians, researchers and the community at the 2012 Center for Vision Research Inherited Retinal Disease symposium.
Summary: The purpose of the study is to investigate the clinical effectiveness of prophylactic treatment of women who have previously undergone preeclampsia and are a part of the risk group for the formation of vascular retinal pathology. Material and Methods. The main group consisted of 40 women aged 24 to 43. The selection criterion was presence of a risk of vascular retinal pathology formation. Women of the main group were prescribed periodic courses of preventive treatment for a period of time of 3-4.5 years. The comparison group consisted of 51 women, who underwent preeclampsia, and also had a risk of forming vascular retinal pathology and did not receive preventive treatment. Results. Systematic conduct of preventive treatment courses with antiplatelet agents and antioxidants to women who have undergone preeclampsia and are at risk of vascular retinal pathology formation have been effective. Conclusion. Frequency of vascular retinal pathology formation in the main group decreased to 15% ...
A Peek Down the Pipeline: Emerging Drug-Delivery Options for Retinal Diseases Steven Yeh, MD, Thoms A. Albini, MD; and Andrew A. Moshfeghi, MD, MBA
Electrophysiologic tests are used widely in the objective functional examinations in different retinal diseases for several reasons as follows: (1) Differentiation of those diseases with similar...
Retinal Examinations for Macular Degeneration Close to 10 million people every year lose their vision as a result of the incurable eye disease, macular
The primary objective of the proposed study is to show that inhaled equimolar mixture of oxygen and nitrous oxide (EMONO) will reduce pain associated with retinal exam in the preterm infant, as compared to the current standard treatment (oral sucrose and topical anaesthesia). The investigators also aim to show that EMONO can be used safely in preterm neonates undergoing retinal exam, and will not result in any increase in apnea, bradycardia, or desaturation in the 24 hours following the exam. Finally, the investigators aim to show that EMONO will keep the infant calm, and make retinal examination easier and less traumatic. ...
A retinal disorder occurs when the retina malfunctions. The retina is the light-sensitive tissue on the inside and back of the eye.
NightstaRx announced the completion of a $45 million Series C financing transaction, the proceeds of which will be used for the upcoming phase 3 trial for Nightstars lead product candidate, NSR…
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IJEAP is an international journal that covers a wide range of the most recent and advanced research in engineering and sciences with rigorous scientific analysis.
Researchers study retinopathy as possible indicator of nephropathy... The number of diabetes mellitus cases is on the rise while the incidence of
Purpose: To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons. Design and Participants: Population-based, cross-sectional study comprising 2050 men and women aged 69 to 97 years without diabetes, living in four communities. Methods: Participants underwent retinal photography and standardized grading of retinal microvascular characteristics, including retinopathy (e.g., microaneurysms, retinal hemorrhages), focal arteriolar narrowing, and arteriovenous nicking. In addition, calibers of retinal arterioles and venules were measured on digitized photographs to obtain an estimate of generalized arteriolar narrowing. Atherosclerosis and its risk factors were obtained from clinical examination and laboratory investigations. Main Outcome Measures: Prevalence of retinal microvascular abnormalities and their associations with measures of atherosclerosis. Results: The prevalence of retinal microvascular abnormalities ...
TY - JOUR. T1 - Retinal microvascular abnormalities and blood pressure in older people. T2 - The Cardiovascular Health Study. AU - Wong, Tien Yin. AU - Hubbard, L. D.. AU - Klein, R.. AU - Marino, E. K.. AU - Kronmal, R.. AU - Sharrett, A. R.. AU - Siscovick, D. S.. AU - Burke, G.. AU - Tielsch, J. M.. PY - 2002/9. Y1 - 2002/9. N2 - Aim: To examine the relation between blood pressure and retinal microvascular abnormalities in older people. Methods: The Cardiovascular Health Study is a prospective cohort study conducted in four US communities initiated in 1989 to 1990. Blood pressure was measured according to standardised protocols at each examination. During the 1997-8 examination, retinal photographs were taken of 2405 people aged 69-97 years (2056 without diabetes and 349 with diabetes). Signs of focal microvascular abnormalities (focal arteriolar narrowing, arteriovenous nicking, and retinopathy) were evaluated from photographs according to standardised methods. To quantify generalised ...
The white dot syndromes are a group of inflammatory chorioretinopathies of unknown etiology which have in common a unique and characteristic appearance of multiple yellow-white lesions affecting multiple layers of the retina, retinal pigment epithelium (RPE), choriocapillaris, and the choroid. They also have overlapping clinical features. We discuss acute retinal pigment epitheliopathy, multiple evanescent white dot syndrome, acute posterior multifocal placoid pigment epitheliopathy, multifocal choroiditis and panuveitis, acute zonal occult outer retinopathy, birdshot chorioretinopathy, and serpiginous choroidopathy. Some of these diseases are associated with a viral prodrome suggesting a possible viral/infectious etiology, while others are associated with a number of systemic processes suggesting an autoimmune etiology. We also review the presentation, evaluation/diagnosis, and treatment of these entities as well as the prognosis. Where applicable we discuss recent advancements in diagnosing and
Is Central Serous Retinopathy (CSR) the new carpal tunnel for a generation of over-stressed and over-loaded information workers who spend far too many hours per day staring at screens of varying dimensions?. Central serous retinopathy (or choroidopathy) is essentially a delamination of the retina when cellular layers that normally serve as a fluid barrier between the choroid and the retina begin to leak. This introduces a bubble or blister of fluid underneath the retina. This results in blurred and dimmed vision.. Although CSR is idiopathic, it has been linked to chronic stress, defined biochemically as elevated serum cortisol levels. This finding is corroborated by an increased incidence of CSR in those with Cushings Syndrome (chronic overexposure to elevated levels of cortisol.) Men are more often affected than women; with an age of onset between 20-50, averaging around 45.. Ive been having progressively worse vision problems since December that I had attributed to floaters or sleep ...
Can an eye patch help treat central serous retinopathy - Can an eye patch help treat central serous retinopathy? No. Csr is typically treated with a watch and wait approach. Occasionally laser can be used to hasten the recovery. New injectable drugs are also being explored.
48-year-old man has had waxing and waning vision in the left eye for the last year from central serous retinopathy. OD is 20/16, OS is 20/16 - 2 months post PDT therapy with Visudyne ...
Purpose: Hypertension is a worldwide problem that contributes to other diseases such as cardiovascular diseases and also ocular diseases. Unfortunately, hypertensive awareness, remain less than optimal. The simplest method to determine the awareness of hypertension retinopathy can be achieve by completing questionnaire. Thus this study was conducted to identify the level of awareness of hypertensive retinopathy.Methods: Sixty four of hypertension patients 37 male and 27 female were assigned into this study where they need to answer 2 set of questionaire. All questionaires were collected as soon as subject finished answering the questions. Result: The questionaire of this research show good validity based on content and face validation done during pilot study. Overall the awareness of the hyperensive retinopathy were low with 23.4% aware about hypertensive retinopathy. Conclusion: Awareness of hypertensive retinopathy still low among hypertension patient in Selangor area. More research about this ...
To view the entire topic, please sign in or purchase a subscription. One often cited side effect is chloroquine retinopathy, which can result in permanent vision loss after high cumulative doses of chloroquine.. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and …. Abstract Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less.. Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 chloroquine retinopathy had received daily doses of 250 mg or less. In a pigmented rabbit model of chloroquine toxicity, serum hypo- and dysproteinemia developed with decreases in serum albumin and alpha 1 and 2 globulin fractions and increases in beta ...
Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure (i.e. hypertension). Most patients with hypertensive retinopathy have no symptoms. However, some may report decreased or blurred vision, and headaches. Signs of damage to the retina caused by hypertension include: Arteriolar changes, such as generalized arteriolar narrowing, focal arteriolar narrowing, arteriovenous nicking, changes in the arteriolar wall (arteriosclerosis) and abnormalities at points where arterioles and venules cross. Manifestations of these changes include Copper wire arterioles where the central light reflex occupies most of the width of the arteriole and Silver wire arterioles where the central light reflex occupies all of the width of the arteriole, and arterio-venular (AV) nicking or AV nipping, due to venous constriction and banking. advanced retinopathy lesions, such as microaneurysms, blot hemorrhages and/or flame hemorrhages, ischemic changes (e.g. cotton wool ...
What is Hypertensive Retinopathy?. Hypertensive retinopathy is a condition of retinal vascular changes that occur as a result of prolonged high blood pressure. Read Full Article. ...
Central serous retinopathy, CSR, is a disease in which a serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium (RPE).
Hypertensive retinopathy is related to high blood pressure Hypertensive retinopathy is graded according to seriousness Ophthalmic examination...
Treatment for hypertrophic cardiomyopathy in Chamarajpet, Bangalore, find doctors near you. Book Appointment Online, View Fees, Reviews Doctors for Hypertensive Retinopathy Treatment in Chamarajpet, Bangalore | Practo
This graph shows the total number of publications written about Hypertensive Retinopathy by people in this website by year, and whether Hypertensive Retinopathy was a major or minor topic of these publications ...
Ophthalmologists at New York Eye and Ear Infirmary of Mount Sinai have created a new technique to evaluate patients with sickle cell retinopathy and assess the disease before it progresses and leads to permanent vision loss.
Sickle Cell Retinopathy is recognized by the following codes as per the International Classification of Diseases (ICD) nomenclature:
Quantitative retinal signs were mainly analyzed as continuous variables and qualitative retinal signs were analyzed as binary variables. The association between retinal signs and vascular risk factors was assessed using linear and logistic regression to adjust for age, gender, and race.. In the main analysis, we used linear regression to model each of the DSST score, gait speed, and square root of CES-D score as a function of a retinal sign and covariates, and we used logistic regression to model the probability of depressive mood. Standardized coefficients were computed to compare the strength of associations between retinal signs and each outcome. Depressive symptoms were analyzed in 2 different ways: (1) square root of CES-D score among participants not using antidepressant medications, because CES-D score may not accurately represent the burden of depressive symptoms in these participants; and (2) the presence of depressive mood, as defined, in all participants. Of those with data on all 5 ...
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TY - JOUR. T1 - Assessment of patient-reported outcomes in retinal diseases. T2 - a systematic review. AU - Prem Senthil, Mallika. AU - Khadka, Jyoti. AU - Pesudovs, Konrad. N1 - Copyright © 2017 Elsevier Inc. All rights reserved.. PY - 2017/1/8. Y1 - 2017/1/8. N2 - Advances in the understanding of the genetic, molecular, and cellular biology of retinal diseases have led to the development of new treatments. These expanding treatment options demand appropriate outcome measures for studies of treatment benefit including patient-reported outcomes (PROs). A plethora of PRO instruments assess impacts of retinal diseases from the patients perspectives. We review all the studies that implemented PRO assessment in retinal diseases and also discuss quality assessment of the PRO instruments. We also include qualitative studies that explored quality of life impact on people with retinal diseases. Most studies used PRO instruments not specifically developed for retinal diseases (non-disease specific), ...
Hypertensive retinopathy is a syndrome that commonly affects older cats causing an abrupt onset of bilateral blindness. This condition is often associated with a cat that suddenly begins to bump into things, appears to be lost, and displays very cautious movements. The loss of vision is associated with dilated pupils that are unresponsive or poorly responsive to incoming light. Affected eyes may appear slightly cloudy, and focal red areas may be visible thorough the pupil, as a result of retinal hemorrhage. This condition is often associated with a systemic hypertension, which is another term for high blood pressure. The retina is a thin-layered photo sensory nerve tissue, that is closely adhered to the posterior fibrous coat of the eye. When rays of light enter the eye they are focused onto the retina by the cornea and the lens. The retina then transmits a signal to the optic nerve for the brain to interpret as an image. The retina itself contains blood vessels making it vulnerable to damage ...
Trusted Hypertensive Retinopathy Specialist serving DeSoto, TX & Plano, TX. Visit our website to book an appointment online: Retina Specialists
Hypertensive retinopathy is a complication of high blood pressure (hypertension) affecting the retina. Learn about it here and schedule an eye exam now!
Approach and Results-Pregnant Sprague Dawley rats were fed LS (0.03% NaCl) or normal salt (0.3% NaCl) diets, and ischemic retinopathy was induced in the offspring. An LS diet reduced retinal neovascularization and vaso-obliteration, the mRNA and protein levels of the angiogenic factors, vascular endothelial growth factor, and erythropoietin. Microglia, which influence vascular remodeling in ischemic retinopathy, were reduced by LS as was tumor necrosis factor-α. Macroglial Müller cells maintain the integrity of the blood-retinal barrier, and in ischemic retinopathy, LS reduced their gliosis and also vascular leakage. In retina, LS reduced mineralocorticoid receptor, angiotensin type 1 receptor, and renin mRNA levels, whereas, as expected, plasma levels of aldosterone and renin were increased. The aldosterone/mineralocorticoid receptor-sensitive epithelial sodium channel alpha (ENaCα), which is expressed in Müller cells, was increased in ischemic retinopathy and reduced by LS. In cultured ...
NDP-related retinopathies are X-linked recessive disorders characterized by very early childhood eye diseases/disorders due to degenerative and proliferative changes of the neuroretina. The spectrum of retinal findings ranges from Norrie disease (ND) to X-linked familial exudative vitreoretinopathy (FEVR), including some cases of persistent hyperplastic primary vitreous (PHPV), Coats disease, and advanced retinopathy of prematurity (ROP). These phenotypes appear to be a continuum of retinal findings with considerable overlap. The ocular findings that permit a presumptive diagnosis of an NDP-related retinopathy include the following: Bilateral, often symmetric, involvement of the eyes Normal-sized eyes, with normal anterior chambers and usually clear lenses at birth Vitreous abnormalities (hemorrhage, membranes, detachment, and/or vitreoretinal attachments) Presence of fibrous and vascular retinal changes at birth with progressive changes through childhood or adolescence The most severe phenotype ...
Retinitis Pigmentosa and other inherited retinal diseases can now be diagnosed with advanced electrophysiology, optical imaging, and genetic testing. In addition, innovative thereuputics including gene therapy and cell transplant are now being tested by our faculty.. ...
Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potential role as a neuroprotective agent for retinal diseases has received little attention. In addition, DMFs mode of action remains elusive, although studies have suggested nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an important mechanism. Here we investigated the neuroprotective role of monomethyl fumarate (MMF), the biologically active metabolite of DMF, in retinal ischemia-reperfusion (I/R) injury, and examined the role of Nrf2 in mediating MMF action. Wild-type C57BL/6J and Nrf2 knockout (KO) mice were subjected to 90 min of retinal ischemia followed by reperfusion. Mice received daily intraperitoneal injection of MMF. Inflammatory gene expression was measured using quantitative
OBJECTIVE:. The objective of this study is to investigate whether there is a correlation between genetic mutations, beginning with an analysis of ABCA4, and Plaquenil -induced retinal toxicity and to describe the phenotype of Plaquenil -induced retinal toxicity.. STUDY POPULATION:. The study will enroll 45 patients, 18 years of age or older, found to have Plaquenil -induced retinal toxicity. Seventy-five volunteers with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or Sj(SqrRoot)(Delta)gren s syndrome and history of Plaquenil use, but without evidence of retinal toxicity, will also be recruited.. DESIGN:. The study is an observational study with 1-2 outpatient visits to the NEI clinic or review of medical records for off-site participants. All participants will provide a blood sample for genetic analysis.. OUTCOME MEASURES:. Clinical examination and blood samples will be used for genetic testing and mutation identification. The outcome of this study is to identify genetic ...
In the evaluation of retinal findings, the development and progression of retinopathy were defined as a change of 2 steps up or more in a modified ETDRS scale of 19 stages in the Kumamoto Study, 3 steps up or more in a ETDRS scale of 25 stages in the DCCT, and 2 steps up in a modified ETDRS scale of 21 stages in the UKPDS (2,6,9 11,16). Because the patients with preproliferative retinopathy at the initiation of the study were not included in the Kumamoto Study, this classification system of 19 stages allowed us to evaluate the retinal findings efficiently. The cumulative percentage of patients showing the worsening in retinal findings was significantly less in patients receiving intensive insulin treatment than in those receiving conventional insulin treatment. With intensive insulin therapy, the risks of retinopathy were reduced in the primary prevention, the secondary intervention, and the combined cohorts. The risk calculated by proportional-hazards analysis in the combined cohort was ...
Purtschers retinopathy characterized by the appearance of cotton-wool spots and intraretinal hemorrhage at the posterior pole that commonly occurs after severe head and chest trauma. We report a pati...
The study shows that people with type 2 diabetes without retinopathy at the time of their first retinal examination were at low risk of progressing to preproliferative retinopathy (requiring referral to an ophthalmologist) and at very low risk of progressing to either PDR or maculopathy (requiring treatment) even after 5 years of follow-up. In contrast, patients with nonproliferative or preproliferative retinopathy at their first retinal examination were at much higher risk of progression. These findings support increasing the screening intervals in people with diabetes and without retinopathy detected at earlier screening examinations and are in keeping with our previous analysis of retinopathy prevalence at screening (5) and with other longitudinal studies of retinopathy incidence and progression (6,10-13). In this program, 80% of patients had no retinopathy at their first examination, so screening them less frequently could substantially reduce costs, allow limited resources to be shifted to ...
The retina is the light-sensitive layer of tissue at the back of the inner eye. It acts like the film in a camera - images come through the eyes lens and are focused on the retina. The retina converts these images to electrical signals and sends them via the optic nerve to the brain, allowing us to see. Retinal diseases disrupt your retinas ability to do its job, affecting your vision.. Mount Sinai offers expertise in the diagnosis and treatment of retinal disease. Our researchers and clinicians have been engaged in the field of eye care and research since the mid-1880s. More than 18,000 people seek eye care at Mount Sinai each year. Our eye care professionals are dedicated to providing you with the finest treatment available today.. Our retinal disease specialists include:. Scott E. Brodie, MD, PhD ...
While our programs focus is on training outstanding vitreoretinal surgeons, a strong medical retina and uveitis clinic supports our fellows training on the medical aspects of retinal diseases. The fellow has extensive exposure to the medical management of common retinal diseases as well as some of the most challenging medical retina conditions a retina physician may face. Clinical training encompasses retinal degenerative diseases with numerous opportunities for intravitreal injections, inherited retinal diseases, in-office care of peripheral retinal pathologies including pneumatic retinopexy and laser retinopexy using both slit-lamp laser delivery system and indirect ophthalmoscopy lasers. Our clinic is equipped with photodynamic therapy (PDT) laser for the patients who need this treatment modality and our fellow has the opportunity to participate in it. We are proud of having state of the art retina imaging facility and fellows will learn to interpret imaging data from a variety of modalities ...
Gazing at a the sun can cause a small macular burn with central vision loss. Learn more at Bennett & Bloom Eye Centers serving Louisville and more.
Diabetic retinopathy is best diagnosed with a dilated eye exam. A yearly eye exam at our Calgary eye clinic can help prevent diabetic vision loss.
a)Health benefits policies may not require that an optometrist hold hospital staff privileges.. (b)When any health benefits policy provides for the payment of eye care benefits or vision care benefits, such policy shall be construed to include payment to all eye care providers who provide benefits within the scope of their providers licenses.. (c)Any limitation or condition placed upon services, diagnosis or treatment by or payment to a particular type of licensed provider shall apply equally to all licensed providers without unfair discrimination as to the usual and customary treatment procedures of an eye care provider.. (d)Any health benefits policy that includes eye care benefits, including a diabetic retinal examination, shall provide each covered person diagnosed with diabetes direct access to an eye care provider of their choice from the insurers panel of providers independent of, and without referral from, any other provider or entity for one annual diabetic retinal examination. The ...
Figure caption and citation for the preceding image starts]: Nonproliferative diabetic retinopathy: exudate (yellow arrow), microaneurysms (red arrow), cotton wool spot (white arrow), nerve fiber layer hemorrhage (green arrow) Courtesy of Moorfields Photographic Archive; used with permission [Citation ends]. Blood vessels in the eye may leak fluid into the retina, which leads to blurred vision. Proliferative diabetic retinopathy (PDR) is the more advanced form of the disease. New blood vessels start to grow in the eye (neovascularization), which are fragile and can hemorrhage. ...
We have not found evidence that deletions within the D4Z4 repeat array are associated with abnormal regulation of gene expression on chromosome 4q35. Only a single gene within 8 Mb of the D4Z4 repeat, LRP2BP, showed abnormal expression that was specific to FSHD. However, neither this gene nor FRG1 itself showed imbalance of allelic expression. Although we did observe a weak correlation between size of the residual D4Z4 array and expression level for FRG1, we did not observe upregulation of FRG1 mRNA in FSHD, assessed either by microarray analysis or qRT-PCR. In the context of recent transgenic mouse models, in which 20-fold or greater overexpression of FRG1 was required to induce skeletal myopathy,14 it is noteworthy that none of the FSHD muscle samples in the current study showed ,1.5-fold upregulation of FRG1 by microarray analysis. We also considered models involving longer range effects of the FSHD deletion on 4q gene expression, either through mislocalization of the mutant chromosome in the ...
دليل المعلومات الطبي يحتوي على مكتبة طبية, موسوعات, منتديات, والمزيد من المعلومات الطبية المفيدة لكل الطلاب والدارسين في المجال الطبي.
To study the relationship between cone spacing and density and clinical measures of visual function near the fovea. High-resolution images of the photoreceptor mosaic are obtained with Adaptive Optics Scanning Laser Ophthalmoscopy. ...
Retinal diseases can severely affect the sight and health of the eye. Our retinal surgeons, Dr. Ko and Dr. Glazer-Hockstein at our Wilmington office focus on retinal diseases detachment, tears, and vascular disease and provide treatments that restore health and sight to the patient.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Salmon JF (13 December 2019). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic approach (9th ed.). ... Valsalva retinopathy is a form of retinopathy due to retinal bleeding secondary to rupture of retinal vessels caused by ... Valsalva retinopathy is a form of sub-retinal, sub-hyaloid or sub-internal limiting membrane hemorrhage occur due to rupture of ... retinal vessels caused by a strenuous physical activity. Physical exertion like weight lifting and aerobic exercise, coughing, ...
John F., Salmon (2020). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic approach (9th ed.). ... Although often brief and harmless, they may be a sign of retinal detachment. Retinal detachment: Symptoms include floaters, ... A retinal migraine is when you have only visual symptoms without a headache. Reduced blinking: Lid closure that occurs too ... "WHO , Priority eye diseases". WHO. Retrieved 2020-09-02. Coursey, Terry G; de Paiva, Cintia S (2014-08-04). "Managing Sjögren's ...
List of systemic diseases with ocular manifestations Progressive outer retinal necrosis "Cytomegalovirus retinitis: MedlinePlus ... "Inflammatory Retinal Diseases. Medical information , Patient". Patient. Retrieved 2016-03-16. V, Narendran; Kothari, Abhishek ( ... Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil ... Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be ...
"Inflammatory Retinal Diseases. Medical information". patient.info. Retrieved 2020-04-25. "Cytomegalovirus Adult and Adolescent ... This corticosteroid is usually used to treat disorders and diseases including macular edema secondary to retinal vein occlusion ... "Intravitreal Steroids for the Treatment of Retinal Diseases". The Scientific World Journal. 2014: 1-15. doi:10.1155/2014/989501 ... in turn curing various eye diseases. Disorders/diseases that can be treated with intravitreal injection include: Age-related ...
Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. Vol. 572. pp. 29-33. doi:10.1007/0-387-32442-9_5 ... Rao KN, Zhang W, Li L, Anand M, Khanna H (2016b) Prenylated retinal ciliopathy protein RPGR interacts with PDE6delta and ... Rao KN, Li L, Anand M, Khanna H (2015). "Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary ... Murga-Zamalloa CA, Desai NJ, Hildebrandt F, Khanna H (July 2010). "Interaction of ciliary disease protein retinitis pigmentosa ...
"Acucela - Retinal Diseases". acucela.com. Retrieved 2016-03-01. Protein Structure and Function Båvik CO, Busch C, Eriksson U ( ... The photoisomerization of 11-cis-retinal to all-trans-retinal initiates the phototransduction pathway through which the brain ... multiplex PCR and mutation screening in patients from India with retinal degenerative diseases". Journal of Genetics. 81 (1): ... "Entrez Gene: RPE65 retinal pigment epithelium-specific protein 65kDa". Wolf G (Mar 2005). "Function of the protein RPE65 in the ...
Retinal Vascular Disease. Springer. pp. 430-. ISBN 978-3-540-29541-9. Retrieved 29 June 2010. Conley, C. Lockard (1952). "A ... and only a small proportion will proceed to develop this disease (which causes joint pains, skin problems and kidney failure, ...
Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. Vol. 801. pp. 291-300. doi:10.1007/978-1-4614- ... single-disease hypothesis holds for Mendelian disorders such as Huntington's disease and cystic fibrosis, complex diseases and ... Celiac disease (CD) is a complex immune disorder that has been found to have strong genetic links in disease. In particular, ... In the table below is a performance comparison of diseases selected on disease frequency and known heritability estimates, with ...
"Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69. doi:10.1016/j.preteyeres.2017.01. ... over 100 disease-causing mutations have been related to BVMD as well as a number of other degenerative retinal diseases. Adult- ... Retinal Degenerative Diseases. review. Advances in Experimental Medicine and Biology. Vol. 723. pp. 603-10. doi:10.1007/978-1- ... Mutations in the BEST1 gene have been identified as the primary cause for at least five different degenerative retinal diseases ...
Landrum, John T; Nolan, John (18 October 2013). Carotenoids and Retinal Disease. CRC Press. ISBN 9781466502055. "Brain and ... Carotenoids and Retinal Disease. Further conferences on Macular Carotenoids at Downing College were held in 2013 and 2015. The ...
Bedford, Peter (2006). "Hereditary Retinal Diseases" (PDF). Proceedings of the 31st World Congress of the World Small Animal ... CEA can also cause retinal or scleral coloboma, coloboma of the optic disc, retinal detachment, or intraocular hemorrhage. It ... It can be a mild disease or cause blindness. CEA is caused by a simple autosomal recessive gene defect. There is no treatment. ... Lowe J, Kukekova A, Kirkness E, Langlois M, Aguirre G, Acland G, Ostrander E (2003). "Linkage mapping of the primary disease ...
"Retinal diseases - Symptoms and causes". Mayo Clinic. "Understanding how immune cells cause scarring in wet age-related macular ... Macular scarring is formation of the fibrous tissue in place of the normal retinal tissue on the macular area of the retina ...
Minireview: Fibronectin in retinal disease. Exp Biol Med (Maywood). 2017 ;242(1):1-7 Goyal R, Vega ME, Pastino AK, Singh S, ...
Structural implications for retinal disease". FEBS Letters. 528 (1-3): 17-22. doi:10.1016/S0014-5793(02)03241-6. PMID 12297272 ... A second product of Meta II decay is an all-trans-retinal opsin complex in which the all-trans-retinal has been translocated to ... This means replacing all-trans-retinal with 11-cis-retinal and the decay of Meta II is crucial in this process. During the ... Park PS (2014). "Constitutively active rhodopsin and retinal disease". Pharmacology & Therapeutics of Constitutively Active ...
CRISPR Genome Surgery in Stem Cells and Disease Tissues , Stephen Tsang , Elsevier. Atlas of Inherited Retinal Diseases , ... Professor Tsang studies metabolic signaling in retinal diseases, as well as gene therapy and stem cell therapy to treat such ... He also edited a book on inherited retinal diseases. He has authored over 280 peer reviewed articles, including articles ... diseases. In 2010, Tsang led an international research team that used embryonic stem cells of mice to replace diseased retinal ...
Structural implications for retinal disease". FEBS Letters. 528 (1-3): 17-22. doi:10.1016/s0014-5793(02)03241-6. PMID 12297272 ... Audo I, Robson AG, Holder GE, Moore AT (2008). "The negative ERG: clinical phenotypes and disease mechanisms of inner retinal ... The third mutation is Ala292Glu, and it is located in the seventh transmembrane helix, in proximity to the site of retinal ... Nakamura M, Ito S, Piao CH, Terasaki H, Miyake Y (July 2003). "Retinal and optic disc atrophy associated with a CACNA1F ...
Bhattacharya, Sanjoy (May 2009). "Retinal deimination in aging and disease". IUBMB Life. 61 (5): 504-509. doi:10.1002/iub.184. ... Citrullinated vimentin may be an autoantigen in RA and other autoimmune diseases, and is used to study RA. Moreover, antibodies ... In adults, MBP deimination is found in demyelination diseases such as multiple sclerosis. MBP may affect different cell types ... Citrullinated proteins are also found in the cellular debris accompanying the destruction of cells in alzheimer disease, and ...
"Retinal astrocytic hamartoma and Bourneville's disease". Oman J Ophthalmol. 5 (3): 198-9. doi:10.4103/0974-620X.106108. PMC ... Retinoblastoma protein Coats' disease Trilateral retinoblastoma Pinealoblastoma India portal Medicine portal Long link - please ... PMID 29380786.{{cite journal}}: CS1 maint: multiple names: authors list (link) Honavar SG (2018). "Retinal vasoproliferative ... "Rosai dorfman disease of the orbit". J Hematol Oncol. 1: 7. doi:10.1186/1756-8722-1-7. PMC 2474646. PMID 18588698.{{cite ...
August 2020). "Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases". Eye. 34 (8): 1341-1356. doi: ... Over time, progressive retinal damage may appear on a retinal exam, first with small bulges in retinal blood vessels called ... Gupta A, Cavallerano J, Sun JK, Silva PS (17 October 2016). "Evidence for Telemedicine for Diabetic Retinal Disease". Seminars ... The earliest changes leading to diabetic retinopathy include narrowing of the retinal arteries associated with reduced retinal ...
Song D, Dunaief JL (2013). "Retinal iron homeostasis in health and disease". Frontiers in Aging Neuroscience. 5: 24. doi: ... copper storage disease). Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency ... This test is to determine if there are signs of Wilson disease. Another test that can be done is a urine copper level test; ... O'Brien PJ, Bruce WR (2009). Endogenous Toxins: Targets for Disease Treatment and Prevention, 2 Volume Set. John Wiley & Sons. ...
Retinal diseases at TU Teaching Hospital. J.K. Shrestha, S. Koirala, OK Malla, S. Miller. Journal of the 1997, 19:13-17. 11. ... 2. Von 's disease (Neurofibromatosis): Case report: P.C. Karmacharya, S. Koirala, M.P. Upadhyay J. Inst. Med. P. 113 3. ... 1992; 30:120-124). 7. Knowledge Attitude and Practice (KAP) Towards Eye disease: Finding of a Survey in Rural Bhaktapur. ...
By analogy to Coats disease, the exudative retinopathy is thought to result from breakdown of the blood-retinal barrier at the ... doctor/1926 at Who Named It? Coats G (Nov 1908). "Forms of retinal disease with massive exudation". R Lond Ophthalmol Hosp Rep ... These findings mimic Coats disease. Characteristically, the abnormal vessels are localized and the retinal blood vessels ... In some eyes, retinal vessels form small nodules on the surface of the retina, known as angiomas. These can bleed and be ...
"Retinal ganglion cell degeneration in Alzheimer's disease". Brain Research. 501 (2): 364-372. doi:10.1016/0006-8993(89)90653-7 ... Sadun has focused his research on diseases of the optic nerve, diseases of mitochondrial impairment, optic nerve regeneration, ... Progress in retinal and eye research, 23(1), 53-89. Pan, B. X., Ross-Cisneros, F. N., Carelli, V., Rue, K. S., Salomao, S. R., ... In these and other studies, he has also investigated the role of mitochondria in aging and disease in the brain, optic nerve ...
The Retinal Pigment Epithelium: Function and Disease. Gallemore RP, Hughes BA and Miller SS (1998) "Light-induced responses of ... The Retinal Pigment Epithelium: Function and Disease. Gallemore RP, McCuen B II. (2000) "Silicone oil tamponade in ... "Diagnosis of vitreoretinal adhesions in macular disease with optical coherence tomography." Retina-the journal of retinal and ... Hughes, BA, Gallemore, RP and Miller, SS (1998) "Transport mechanisms in the retinal pigment epithelium". In: The retinal ...
SCGH has the Australian Inherited Retinal Disease Registry and DNA Bank (AIRDR) on-site. AIRDR analyses the DNA of consenting ... The AIRDR resource is available to researchers pursuing an interest in the varying causes of inherited retinal disease. The ... "Australian Inherited Retinal Disease Registry and DNA Bank". Department of Health, Western Australia. 15 September 2020. ... "The Western Australian Inherited Retinal Disease DNA Databank". Australasian Physical & Engineering Sciences in Medicine. ...
Bakall B, Hariprasad SM, Klein KA (July 2018). "Emerging Gene Therapy Treatments for Inherited Retinal Diseases". Ophthalmic ... Leber's congenital amaurosis, or biallelic RPE65-mediated inherited retinal disease, is an inherited disorder causing ... Ameri H (March 2018). "Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal ... "First Gene Therapy For Inherited Disease Gets FDA Approval". NPR. 19 December 2017. Russell S, Bennett J, Wellman JA, Chung DC ...
Gold D, Feiner L, Henkind P (September 1977). "Retinal arterial occlusive disease in systemic lupus erythematosus". Arch. ... leading to a decrease in retinal circulation which, in turn, causes retinal hypoxia. While, most commonly, emboli causing ... Newman NJ (1998). "Cerebrovascular disease". In Hoyt WG, Miller N, Walsh F, Newman NJ (eds.). Walsh and Hoyt's Clinical Neuro- ... Smit RL, Baarsma GS, Koudstaal PJ (1994). "The source of embolism in amaurosis fugax and retinal artery occlusion" (PDF). Int ...
Compositions and methods for correction of heritable ocular disease, (2021). Vision test for determining retinal disease ... Her research focuses on gene therapy for retinal diseases. Her laboratory developed the first FDA approved gene therapy for use ... Currently, her laboratory is investigating gene therapy approaches for other retinal diseases. Sanford Lorraine Cross Award, ... "Vision test for determining retinal disease progression", published 2021-12-28, assigned to The Trustees of the University of ...
Let's Chat About...ProQR's work in treatments for inherited retinal disease. Hope in Focus. YouTube. 31 January 2022. Retrieved ... The company's ultimate goal revolves around treating inherited retinal diseases by stopping and potentially reversing vision ... ProQR is an ophthalmology company targeting genetic diseases by focusing on making changes to the RNA. The firm's RNA editing ... Subsequently, the company expanded its pipeline into treating other rare diseases. In 2017, a spin-out of ProQR named Amylon ...
"RetNet: Genes and Mapped Loci Causing Retinal Diseases". RetNet. Retrieved 12 May 2015. Han J, Dinculescu A, Dai X, Du W, Smith ... Similar to rd1 in mice, Rod-cone dysplasia type 1 (rcd1-PRA) is a form of progressive retinal atrophy (PRA), with early onset ... Anant JS, Ong OC, Xie HY, Clarke S, O'Brien PJ, Fung BK (Jan 1992). "In vivo differential prenylation of retinal cyclic GMP ... PDE6 is a highly concentrated protein in retinal photoreceptors. With the presence of the GAF domain, PDE6 can actively bind to ...
... to develop an implantable microelectronic retinal device that restores useful vision to people blinded by retinal diseases ( ... The center enacted the only FDA-approved visual prosthesis to date (Argus retinal prosthesis or ARGUS II). Co-winner of USDOE/ ...
... therefore falls under the classification of diseases known as ciliopathies. Mutations that have been ... and less commonly there may be twisted retinal blood vessels or optic nerve hypoplasia. The eye anomalies can result in an ... "Strømme Syndrome , Hereditary Ocular Diseases". disorders.eyes.arizona.edu. Archived from the original on 24 July 2017. ...
... fluorescein retinal angiography that demonstrated multifocal retinal artery occlusions without evidence of embolic disease. ... Autoimmune diseases, Neurological disorders, Vascular diseases, Rare syndromes, Syndromes affecting the nervous system). ... Retinal Artery Wall Plaques in Susac Syndrome. American Journal of Ophthalmology 135: 483-6; 2003 Susac JO, Murtagh FR, Egan RA ... Susac's syndrome is a very rare disease, of unknown cause, and many persons who experience it do not display the bizarre ...
... , or Becker's phenomenon, is the presence of visible (through an ophthalmoscope) pulsation of retinal arteries, ... found in patients with aortic insufficiency or Graves' disease. The sign was named after Otto Heinrich Enoch Becker. Corrigan's ...
Trisomy 13 (Patau syndrome) Norrie disease Walker-Warburg syndrome Autosomal dominant Autosomal recessive Causes a 'white ... falciform retinal septum and ablatio falcicormis congenita) and a combination of both. Most examples of PHPV are unilateral and ...
Delahunty was a guest worker at the National Institute of Diabetes and Digestive and Kidney Diseases in the diabetes branch. At ... "ENVIRONMENTAL EFFECTS ON THE METABOLISM OF CARASSIUS AURATUS: ROLE OF THE PINEAL ORGAN AND RETINAL PATHWAYS - ProQuest". ... Role of the Pineal Organ and Retinal Pathways. He received a fellowship from the Arthur J. Schmitt Foundation for his final ...
Chorio-retinal dysplasia i.e. changes in the retina) In 1992, Feingold and Bartoshesky described two unrelated children with ... Genetic diseases and disorders). ...
If we want to understand health and disease, we need to understand life at the molecular level and to know how all the ... He was particularly interested in studying retinal, a polyene and a chromophore of opsins. Schulten was able to provide a ...
Chen PY, Chang WS, Chou RH, Lai YK, Lin SC, Chi CY, Wu CW (2007). "Two non-homologous brain diseases-related genes, SERPINI1 ... Labauge P, Krivosic V, Denier C, Tournier-Lasserve E, Gaudric A (Jun 2006). "Frequency of retinal cavernomas in 60 patients ... a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and ...
Quandt was afflicted with a retinal disease that left scars, and he was nearly blind from the age of nine. Consequently, he had ...
Line Renaud Award of the Fondation pour la Recherche Médicale Retinal gene therapy using lentiviral vectors Viral vector ... as well as prophylactic and therapeutic vaccinations in infectious diseases and oncology. Charneau's development of lentiviral ...
Eye diseases, Syndromes affecting the eye, All stub articles, Disease stubs, Eye stubs). ... retinal, preretinal, subhyaloidal, or intra-vitreal hemorrhage. Its likely cause is a rapid increase in ICP. The classic ...
Articles lacking sources from January 2013, All articles lacking sources, Eye diseases). ... which shows an area of retinal excavation in the region of the staphyloma. ( ...
Sensors play a role in innovations in agriculture and the food industry in order to reduce wastage and detect diseases. Light ... in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings". Light Sci ... allowing the food supply chain to detect disease, ripeness and nutrients in fruit and plants. It can also help food producers ...
Theories suggest that the dis edema is due to retinal vascular leakage into and surrounding the optic nerve and disruption of ... Diabetic papillopathy is a self-limiting disease that may affect both type 1 and type 2 diabetic patients. Unilateral or ... Ramanjit, Sihota; Radhika, Tandon (2015). Parsons' diseases of the eye (Twenty-second ed.). New Delhi, India. p. 369. ISBN 978- ... axoplasmic flow resulting from microvascular disease of the optic nerve head. Edema is seen in and around the optic nerve head ...
Gough, Thomas (2008). Breed predispositions to disease in dogs and cats. Oxford, UK: Wiley. pp. 11-12. ISBN 9780470690802. OCLC ... cataract and generalized progressive retinal atrophy (GPRA). Afghan myelopathy (causing pelvic limb ataxia) is sometimes ...
Knockout rat disease models for Parkinson's disease, Alzheimer's disease, hypertension, and diabetes, using zinc-finger ... The Royal College of Surgeons rat (or RCS rat) is the first known animal with inherited retinal degeneration. Although the ... Knockout rats can mimic human diseases, and are important tools for studying gene function and for drug discovery and ... This mutation results in defective retinal pigment epithelium phagocytosis of photoreceptor outer segments. The shaking rat ...
Colour normalisation of retinal images (PDF) (Report). Mark A. Rubin; Maciej P. Zerkowski; Robest L. Camp; Rainer Kuefer; ... 2002). Classification and localisation of diabetic-related eye disease. Proceedings of the European Conference on Computer ... Colour normalisation of retinal images (PDF) (Report). Image Enhancement by Contrast Transform Archived January 18, 2012, at ... 2002). Classification and localisation of diabetic-related eye disease. Proceedings of the European Conference on Computer ...
RT001 has been shown to be effective in a model of Alzheimer's disease in mice. "9-cis, 12-cis-11,11-D2-Linoleic acid ethyl ... Demidov, Vadim V. (April 2020). "Site-specifically deuterated essential lipids as new drugs against neuronal, retinal and ... PSP is a disease involving modification and dysfunction of tau protein; RT001's mechanism of action both lowers lipid ... dysfunctional glucose metabolism and Alzheimer disease". Nature Reviews. Neuroscience. 20 (3): 148-160. doi:10.1038/s41583-019- ...
The company specialized in developing and manufacturing ophthalmic surgical devices, specifically for retinal diseases.[ ...
"New AI Approach in Retinal Diagnostics Targets Inclusivity for Patients with Sight-Stealing Diseases". Johns Hopkins University ... "outstanding vision scientists whose work contributes to knowledge about vitreoretinal disease." In 2013, Bressler was appointed ... low-shot deep learning does have the potential to overcome limitations imposed by a low number of training images in retinal ...
They include systemic mycoses (fungal infections) and parasitic diseases, as well as eight weeks before and two weeks after ... central retinal vein occlusion, visualization during vitrectomy and the prevention of asthma attacks. The derivative ... Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is ...
Glaucoma Lacrimal (Tear Duct) Disorder Laser treatment Oculo-plastic Services Orbital Disorder Pediatric eye care Retinal ... Cataract surgery Cornea and External Eye Disease Diabetic retinopathy Diagnostic procedures including Fundus Flourescien ... disorders including Vitreo- Retinal Surgery Uveitis Clinic As of 2020, there are 19 fully-equipped hospitals and 58 primary ...
A prion disease called kuru has been traced to this. Brain-computer interface Central nervous system disease List of ... Wong, RO (1999). "Retinal waves and visual system development". Annual Review of Neuroscience. St. Louis, MO. 22: 29-47. doi: ... The most important that are covered in the human brain article are brain disease and the effects of brain damage. The shape and ... All these things we endure from the brain, when it is not healthy... On the Sacred Disease, attributed to Hippocrates The Roman ...
... steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185-195. PMID 12107412. Pizon ... "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease". American Journal of ...
... is a symptom of several common retinal and macular diseases, therefore treating the underlying disorder can ... The retinal mechanism involves the displacement of retinal layers which results in the mislocation of light on the retina. The ... Many of these tests have a poor ability to accurately diagnose or identify a person with the disease (i.e.,poor sensitivity). ... The mechanisms that result in the development of metamorphopsia involve structural changes in the retina of the eye (retinal ...
A pregnant woman from Poland, diagnosed with a severe eye disease, tried to get an abortion to avoid an escalation of her ... Given the serious nature of the applicant's sight impairment, the risk of retinal detachment had always been present and ... disease. Her requests were rejected by several medical doctors and she underwent labor of her third child. Her condition later ...
Retinal haemorrhage (H35.7) Separation of retinal layers Central serous retinopathy Retinal detachment: Detachment of retinal ... Other chorioretinal disorders in diseases classified elsewhere (H33) Retinal detachment - the retina detaches from the choroid ... Peripheral retinal degeneration (H35.5) Hereditary retinal dystrophy (H35.5) Retinitis pigmentosa - genetic disorder; tunnel ... International Statistical Classification of Diseases (WHO ICD-10) - Diseases of the eye and adnexa (ICD-10 codes H00-H59) ...
General availability of retinal photocoagulation in the public health system (Noncommunicable diseases). This indicator is ... General availability of retinal photocoagulation in the public health system (Noncommunicable diseases) ...
retinal diseases Clinical Research Trial Listings on CenterWatch ... Changes in the retinal anatomy that occur in epiretinal ... Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2) (BabySTEPS2) Retinopathy. of prematurity (ROP) is a disorder of ... Extremely premature infants are at risk of developing a potentially blinding eye disease, called retinopathy. of prematurity ( ...
Retinal Hemorrhages in 4 Patients with Dengue Fever. Emerging Infectious Diseases. 2005;11(5):770-772. doi:10.3201/ ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... on virus cultured from serum taken early in the disease. The diagnosis of retinal hemorrhage was made by an ophthalmologist ... Retinal hemorrhages may reflect the rising incidence of dengue in Singapore or may be caused by changes in the predominant ...
... of Stem Cell Reports focuses on stem-cell-derived retinal cell types as an in vitro model for retinal development and disease ... Stem-cell-based therapies for retinal disease are gaining momentum, and clinical trials are currently being conducted in ... Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal ... Ali and colleagues characterize the differentiation of cone photoreceptors in mESC retinal organoids, showing substantial ...
How familiar are you with the management of inherited retinal diseases? Test your knowledge with this quick quiz. ... A New Era in Retinal Disease Management: Targeting New Pathways and Investigating Novel MOAs 0.5 CME / ABIM MOC Credits ... A New Era in Retinal Disease Management: Targeting New Pathways and Investigating Novel MOAs ... Fast Five Quiz: Management of Inherited Retinal Diseases - Medscape - Apr 27, 2022. ...
Establish new methods of early diagnosis and treatment of these diseases - using the eye as a window on to the brain ... These include glaucoma, age-related macular degeneration and some inherited retinal disorders.. The groups work is focused on ... Identify early markers of cell processes in neurodegenerative disease in the eye - including Glaucoma, Alzheimers, Parkinsons ... The process of neurodegeneration is implicated in several degenerative diseases of the retina. ...
... ultimately offering patients new treatment options for several retinal diseases. ... HealthCare have entered into a five-year collaboration agreement to jointly develop new ophthalmic therapies targeting retinal ... diseases. The goal of the strategic research alliance is to accelerate the translation of innovative approaches from the ... Retinal vein occlusion. "Bayer is strongly committed to further expanding its research efforts in the area of retinal diseases ...
EP-3377061-B1 chemical patent summary.
... ocular disease, phototransduction, retina, retinal diseases, retinal ganglion cells, vision, vision loss ... retinal diseases, retinal imaging, rod cell, rods, sub-Airy disk, vision, vision loss, visual cortex ... retinal diseases. Finding Better Ways to Image the Retina Posted on May 13th, 2021. by Dr. Francis Collins ... Like other parts of the eye, the retina can break down, and retinal diseases, including age-related macular degeneration, ...
Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high ... To be included in our narrative review, the article must have described the effect of an antioxidant in a retinal disease ... 24. Masuda T, Shimazawa M, Hara H. Retinal diseases associated with oxidative stress and the effects of a free radical ... This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a ...
The Global Retinal Disease Therapeutics Market size is expected to reach around USD 18,845.6 Million by 2026 and growing at ... Key Highlights points of Retinal Disease Therapeutics Market 2019 :. *Competitive study of the major Retinal Disease ... The Retinal Disease Therapeutics Market Report 2018 is an in depth study analyzing the current state of the Retinal Disease ... Major Players in Retinal Disease Therapeutics Market are: Merck and Co., Inc., Novartis AG, Allergan plc, F. Hoffmann-La Roche ...
Patients with a disease known as retinal vein occlusion (RVO) have a significantly higher incidence of stroke when compared ... "Retinal vein occlusion (RVO) is a retinal vascular disease in which a retinal vein is compressed by an adjacent retinal artery ... Patients with a disease known as retinal vein occlusion (RVO) have a significantly higher incidence of stroke when compared ... Patients With Certain Type Of Retinal Vascular Disease Are At a Higher Risk of Stroke Personalised Printable Document (PDF). ...
The bi-specific approach aims to successfully treat complement-mediated and angiogenesis driven retinal diseases by suppressing ... The bi-specific approach aims to successfully treat complement-mediated and angiogenesis driven retinal diseases by suppressing ... Samsung Biologics to develop treatment for retinal diseases with Kanaph Therapeutics. 24 September 2020 , News ... a bi-specific Fc fusion protein intended to treat retinal diseases.. According to Kanaph Therapeutics, KNP-301 is designed to ...
The clinical presentation of rare retinal diseases is often not described in the literature in detail using state of art ... Patients with rare eye diseases will also benefit from the database as we expect it will give a better insight into their ... Research programmes investigating the natural history, variability and diagnostic approaches of rare eye diseases will be ... the aim of this project is to establish a database to be able to provide detailed clinical information on rare eye diseases - ...
Then we cultured the cell suspensions on a T-75 flask for 18 days and then shook retinal microglia from other retinal cells. We ... Then, we cultured the cell suspensions on a T-75 flask for 18 days and then shook retinal microglia from other retinal cells. ... We found numerous retinal microglia grow and attach to Müller cells 10 days after seeding and increase rapidly on days 14-18. ... In conclusion, this study provides an effective way to isolate and culture retinal microglia from adult human eyes, which may ...
... macular dystrophy and Stargardt disease (MD/STGD); early-onset retinal disease and Leber congenital amaurosis (EORD/LCA); ... A paradigm shift in the delivery of services for diagnosis of inherited retinal disease. J Med Genet 2012;49:322-6. doi:10.1136 ... The molecular basis of human retinal and vitreoretinal diseases. Prog Retin Eye Res 2010;29:335-75. doi:10.1016/j.preteyeres. ... Inherited retinal diseases (IRDs) are a diverse set of Mendelian disorders that are a major cause of inherited blindness across ...
Retinal Dysfunction as an Early Indicator of Neurological Disease at Western Sydney University, listed on FindAPhD.com ... Retinal Dysfunction as an Early Indicator of Neurological Disease. Western Sydney University School of Medicine ... Towards restoring memory dysfunction in prodromal Alzheimers Disease. University of Glasgow TARGETING DNA METHYLATION AS A ... Mechanistic understanding of how Non-Alcoholic Fatty Liver disease (NAFLD) can lead to cardiovascular dysfunction using induced ...
Genetics of Ocular Disease, Acute Retinal Necrosis Syndrome, Phthisis bulbi ...
Morphological and Multifractal Analyses of Retinal Amyloid Deposits for Staging in Alzheimers Disease. ... Alzheimers disease (AD) is the most common cause of dementia and affects millions of people worldwide. The prominence and ... Peter Andrew Charles Neathway (2020). Morphological and Multifractal Analyses of Retinal Amyloid Deposits for Staging in ...
Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ning Cheung, F. M.Amirul Islam, David R. Jacobs, A ... Arterial compliance and retinal vascular caliber in cerebrovascular disease. In: Annals of neurology. 2007 ; Vol. 62, No. 6. pp ... Arterial compliance and retinal vascular caliber in cerebrovascular disease. Annals of neurology. 2007 Dec;62(6):618-624. doi: ... Arterial compliance and retinal vascular caliber in cerebrovascular disease. / Cheung, Ning; Islam, F. M.Amirul; Jacobs, David ...
Specialist Certificate in Glaucoma and Retinal Disease ... Specialist Certificate in Glaucoma and Retinal Disease ...
Euro BMBF-funding for retinal disease research. With more than 150 million affected people, retinal degenerative diseases are ... Retinal diseases are associated with build-up of waste products. Vision loss may occur, for example, when the retinal pigment ... This process, known as phagocytosis, is essential for visual function and survival of our light sensitive retinal neurons, ... Abnormal RPE cell function can lead to retinal degeneration, visual impairment and even loss of sight. Therapeutic compounds ...
Hunt D, Buch P, Michaelides M. Guanylate cyclases and associated activator proteins in retinal disease. Molecular and Cellular ... Hunt, David ; Buch, P. ; Michaelides, M. / Guanylate cyclases and associated activator proteins in retinal disease. In: ... Hunt, D, Buch, P & Michaelides, M 2010, Guanylate cyclases and associated activator proteins in retinal disease, Molecular ... Hunt, D., Buch, P., & Michaelides, M. (2010). Guanylate cyclases and associated activator proteins in retinal disease. ...
The Duke Center for Retinal Degenerations and Ophthalmic Genetic Diseases offers a one-year training program for one fellow ... The Duke Center for Retinal Degenerations and Ophthalmic Genetic Diseases offers a one-year training program for one fellow ... The fellowship will prepare the fellow to work independently as an inherited retinal disease specialist. The candidate will ... and metabolic diseases that affect the eye, as well as autoimmune retinopathies and other phenocopies of inherited retinal ...
... how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs ... Researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited ... Potential of precision genome editing in treating inherited retinal diseases: Research. ANI , Updated: Sep 25, 2022 05:38 IST ... Inherited retinal diseases (IRDs) are a genetically heterogeneous group of blinding disorders characterized by a progressive ...
Fundus Image Classification and Retinal Disease Localization with Ophthalmologist Intervention 0 views * Share * Embed. Static ... How to Extract More Information with Less Burden: Fundus Image Classification and Retinal Disease Localization with ... How to Extract More Information with Less Burden: Fundus Image Classification and Retinal Disease Localization with ... How to Extract More Information with Less Burden: Fundus Image Classification and Retinal Disease Localization with ...
... an eye disease that can lead to childhood vision loss. ... classifies vision loss and retinal changes in Stargardt disease ... medicalxpress.com/news/2022-01-vision-loss-retinal-stargardt-disease.html ... an eye disease that can lead to childhood vision loss. ...
... and copper play important roles both in retinal physiology and disease. They are involved in various retinal functions such as ... Home › Related Articles › Iron, zinc, and copper in retinal physiology and disease. ... Iron accumulation in the retina, a characteristic of aging, may be involved in the pathogenesis of retinal diseases such as age ... Iron, zinc, and copper in retinal physiology and disease.. Abstract: The essential trace metals iron, zinc, ...
Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number ... Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number ... Purpose: Part of the hidden genetic variation in heterogeneous genetic conditions such as inherited retinal diseases (IRDs) can ... Finally, this IRD-oriented CNV study can serve as a paradigm for other genetically heterogeneous Mendelian diseases with hidden ...
The use of retinal biomarkers may be used for early detection of in vivo Alzheimer disease pathologic abnormalities after ... RESILIENT Long-Term Extension Data, Associations Between Abuse and Migraine, Retinal Biomarkers in Alzheimer Disease. ... Future Leaders in NeurologyDisease Spotlight: NMOSDDisease Spotlight: InsomniaECTRIMS 2022NEALS 2022 ... Future Leaders in NeurologyDisease Spotlight: NMOSDDisease Spotlight: InsomniaECTRIMS 2022NEALS 2022 ...
  • The process of neurodegeneration is implicated in several degenerative diseases of the retina. (ucl.ac.uk)
  • The formation of reactive oxygen species occurs primarily from the mitochondrial respiratory chain as well as several enzymatic and oxidation reactions that occur in the neurosensory retina and retinal pigment epithelium. (dovepress.com)
  • This project aims to characterise the function of neurotransmitter systems in the retina, such as dopamine and acetylcholine, and apply that knowledge to diagnose diseases such as Parkinson's, Alzheimer's, ADHD and diabetes. (findaphd.com)
  • Vision loss may occur, for example, when the retinal pigment epithelial cells (RPE), which underlie the neural retina, are impaired in taking up and recycling natural waste products of the retina. (medizin-aspekte.de)
  • Iron accumulation in the retina, a characteristic of aging, may be involved in the pathogenesis of retinal diseases such as age-related macular degeneration (AMD). (jostchemical.com)
  • The use of retinal biomarkers may be used for early detection of in vivo Alzheimer disease pathologic abnormalities after results from a cross-sectional study demonstrated both functional and structural changes of the retina in cognitively normal older adults. (neurologylive.com)
  • When the retina retracts from the blood vessels supplying oxygen, it results in a medical emergency known as retinal detachment. (eyetx.com)
  • As the disease progresses, blood vessels that nourish the retina may swell and distort. (kelliseyeandlasercenter.com)
  • Accompanying scar tissue can contract and cause retinal detachment-the pulling away of the retina from the underlying tissue, like wallpaper peeling away from a wall. (kelliseyeandlasercenter.com)
  • Retinal detachment occurs when the thin lining at the back of your eye, called the retina, begins to pull away from its blood supply of oxygen and nutrients. (kelliseyeandlasercenter.com)
  • When a retinal vein is blocked, it cannot drain blood from the retina. (kelliseyeandlasercenter.com)
  • Our team of 17 board certified retina physicians and surgeons have the knowledge and experience to treat the most complex retinal diseases and disorders. (southeasternretina.com)
  • Branch retinal vein occlusion blocks the small arteries in the retina and is often caused by high blood pressure. (southeasternretina.com)
  • There are many inherited retinal diseases that affect the macula and retina and can cause severe vision loss. (southeasternretina.com)
  • Lattice degeneration is a condition that causes thinning and weakening of the peripheral retina, the light-sensitive layer of cells lining the back of the eye, which can lead to a retinal tear. (southeasternretina.com)
  • These very powerful light beams can help destroy abnormal blood vessels in the retina or act to seal off retinal tears. (rieyeinstitute.com)
  • Most retinal surgery involves first removing the vitreous gel (the clear fluid inside the eye), and then using delicate instruments to remove any abnormal tissue from the surface of the retina. (rieyeinstitute.com)
  • AMD is a disease that affects the macula, the small area in the center of the retina that allows fine details to be seen clearly. (rieyeinstitute.com)
  • 1 Additional significant structures of the retina include arteries and veins, which provide essential oxygen and nutrients to the retina and maintain retinal circulation. (vision-relief.com)
  • RVO is the second most common disease of blood vessels within the retina, the first being diabetic retinopathy. (vision-relief.com)
  • Data should demonstrate feasible methods and technology to generate retina organoids with maximum relevance to human physiology and disease. (nih.gov)
  • Solutions will be evaluated for establishment of a human PSC-derived in vitro retina model system that resembles the morphology of a healthy-native retina and is viable through formation of photoreceptor outer segments and/or long-term survival of retinal ganglion cells with extension of axonal processes. (nih.gov)
  • Characterization of retinal cell types, retina organoid structure, and retina organoid function are expected. (nih.gov)
  • The most common cause of this dulling in an adult is a cataract , but an abnormal red reflex may also clue you in to other pathologies in the cornea (abrasion, infection, or scar), vitreous (hemorrhage or inflammation), or retina (retinal detachment). (moviecultists.com)
  • Eyes with other anterior segment abnormalities, retina disease, or glaucoma can be included. (who.int)
  • Retinal detachment (see the image below) refers to separation of the inner layers of the retina from the underlying retinal pigment epithelium (RPE, choroid). (medscape.com)
  • Diseases involving the RETINA . (bvsalud.org)
  • A vitreoretinal specialist is a medical professional who specializes in the diagnosis, management, and treatment of diseases and conditions affecting the macula, peripheral retina, and/or vitreous gel. (myvision.org)
  • This professional differs from a general ophthalmologist in that their primary focus is the treatment of vitreoretinal diseases affecting the retina and vitreous. (myvision.org)
  • elbow dysplasia, Legg-Calvé-Perthes disease (degeneration of the femoral head which can cause lameness and joint swelling), intervertebral disc disease (pressure on the spinal cord that can cause paralysis), progressive retinal atrophy (PRA: degeneration of retina which can lead to blindness), epilepsy and blindness. (omlet.us)
  • The sessions saw a range of specialists speak on topics like medical retina, surgical retina, vitero-retinal surgery and retinal pot pourri. (thenewswingz.com)
  • Regular retinal examination in every 6 months is mandatory to detect early changes in retina. (thenewswingz.com)
  • In advanced solutions, Fundus Cameras is the device that helps to document the retina of the eyes which translates the optical image and enables Optometrists to see it in other electric devices to diagnose the disease. (marketdensity.com)
  • These include glaucoma, age-related macular degeneration and some inherited retinal disorders. (ucl.ac.uk)
  • Tam and team are currently working with physician-scientists in the NIH Clinical Center to image the retinas of people with a variety of retinal diseases, including age-related macular degeneration (AMD), a leading cause of vision loss in older adults. (nih.gov)
  • Early, encouraging results from two human studies - trials launched by Bionic Sight and GenSight - are putting optogenetic therapies in the spotlight for patients with advanced vision loss (i.e., only light perception) from retinal conditions such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). (fightingblindness.org)
  • The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments and cures for people affected by retinitis pigmentosa, macular degeneration, Usher syndrome and the entire spectrum of retinal degenerative diseases. (fightingblindness.org)
  • Currently, triamcinolone acetonide and dexamethasone are the two steroid preparations used to treat macular edema associated with central retinal vein occlusion (CRVO). (medscape.com)
  • The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study is a National Eye Institute-sponsored randomized controlled trial comparing 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone acetonide versus observation for visual acuity loss due to macular edema associated with perfused CRVO. (medscape.com)
  • Aerie's retinal therapeutics development programs are focused on significant retinal diseases, including age-related macular degeneration (AMD) and diabetic macular edema (DME), that represent major causes of sight-impairment and blindness in adults worldwide. (aeriepharma.com)
  • Age-related macular degeneration (AMD) is a disease that blurs the sharp, central vision you need for "straight-ahead" activities such as reading, sewing, and driving. (kelliseyeandlasercenter.com)
  • Macular puckers usually arise from age-related changes in the vitreous gel but can result from any type of eye injury, inflammation, disease, or surgery. (southeasternretina.com)
  • The most common retinal diseases are diabetic retinopathy, age-related macular degeneration, and retinal detachments. (rieyeinstitute.com)
  • This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. (elsevier.com)
  • Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration but also found in glomerulonephritis . (bvsalud.org)
  • Retinal Disease Eyes diagnosed with retinal diseases as confirmed at the study visit or prior visits including but not limited to, age-related macular degeneration, diabetic retinopathy, diabetic macular edema, macular hole, epiretinal membrane. (who.int)
  • Objective: analysis of the official statistical data on the disease and availability of health care to patients with age-related macular degeneration (AMD) and diabetic retinopathy (DR) that are prescribed intravitreal injection of drugs (IVD) as the first-line therapy for wet age-related macular degeneration and diabetic macular edema, respectively. (idmz.ru)
  • Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. (ox.ac.uk)
  • Here we describe five families affected by an adult-onset retinal dystrophy with early macular involvement and associated central visual loss in the third or fourth decade of life. (ox.ac.uk)
  • As a result, AI-based diagnostic systems are in development for many other eye diseases, including cataract, age-related macular degeneration (AMD ), and glaucoma . (nih.gov)
  • Prolonged exposure to blue rays is causing multiple optical defects and diseases like macular degeneration, retinal damage, Computer Eye Syndrome and Cataract. (thescholartimes.com)
  • Studies reveal that smoking increases your vulnerability to diseases like Age-Related Macular Degeneration, Dry Eye Syndrome, Glaucoma, including Cataract. (thescholartimes.com)
  • More serious, even sight-threatening eye problems and diseases related to age include glaucoma, retinal detachment, macular degeneration, cataracts, and diabetic retinopathy. (keeneeyecare.com)
  • We always hear about the increased risk of lung cancer and heart disease from smoking, but it also increases the risk of age-related macular degeneration and cataracts! (keeneeyecare.com)
  • The eye disease caused by multiple reasons including diabetic retinopathy, retinal detachment, age-related macular dystrophy (AMD) and glaucoma. (marketdensity.com)
  • Mutations in BEST1 cause five distinct retinal degenerative diseases, including adult vitelliform macular dystrophy (AVMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC), and retinitis pigmentosa (RP). (ox.ac.uk)
  • Patients with a disease known as retinal vein occlusion (RVO) have a significantly higher incidence of stroke when compared with persons who do not have RVO, according to a report in the March issue of Archives of Ophthalmology, one of the JAMA/Archives journals. (medindia.net)
  • Retinal vein occlusion (RVO) is a retinal vascular disease in which a retinal vein is compressed by an adjacent retinal artery, resulting in blood flow turbulence, thrombus formation, and retinal ischemia," the authors write as background information in the article. (medindia.net)
  • No known effective medical treatment is available for the prevention or treatment of central retinal vein occlusion (CRVO). (medscape.com)
  • Central retinal artery occlusion usually occurs in people between the ages of 50 and70. (southeasternretina.com)
  • retinal vein occlusion (RVO) occurs when there is blockage of a vein. (vision-relief.com)
  • 3,5 A blockage of the central vein is called a central retinal vein occlusion (CRVO) and blockage of smaller vein is called a branch retinal vein occlusion (BRVO). (vision-relief.com)
  • Lowth M. Retinal vein occlusion. (vision-relief.com)
  • 2017. https://patient.info/eye-care/visual-problems/retinal-vein-occlusion . (vision-relief.com)
  • 2020. https://www.asrs.org/patients/retinal-diseases/24/branch-retinal-vein-occlusion . (vision-relief.com)
  • 2019. https://my.clevelandclinic.org/health/diseases/14206-retinal-vein-occlusion-rvo . (vision-relief.com)
  • The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. (vision-relief.com)
  • Ehlers JP, Fekrat S. Retinal vein occlusion: beyond the acute event. (vision-relief.com)
  • Cugati S, Wang JJ, Rochtchina E, Mitchell P. Ten-year incidence of retinal vein occlusion in an older population: the Blue Mountains Eye Study. (vision-relief.com)
  • The STRONG project is a European consortium for the study of a topical treatment of ischaemic central retinal vein occlusion (iCRVO) to prevent neovascular glaucoma (NVG). (europa.eu)
  • The lack of oxygen in the specific tissue (hypoxia) associated with retinal vein occlusion is mostly (but not exclusively) responsible for the subsequent release of angiogenic factors (i.e. vascular endothelial growth factor, VEGF). (europa.eu)
  • At the same time, STRONG was planned to provide important data on age and sex matched normal values of controls and retinal vein occlusion (RVO) patients and the natural course of iCRVO and NVG in a very large and well-investigated cohort. (europa.eu)
  • However, there are many forms of rare secondary glaucomas that develop following other eye diseases, including secondary neovascular glaucoma (NVG) most frequently presenting following ischemic central retinal vein occlusion (iCRVO). (europa.eu)
  • Next to central retinal artery occlusion, chemical burns to the eye, and endophthalmitis, it is one of the most time-critical eye emergencies encountered in the emergency setting. (medscape.com)
  • Next to central retinal artery occlusion, chemical burns to the eye, and endophthalmitis, a retinal detachment is one of the most time-critical eye emergencies encountered in the ED. Retinal detachment (RD) was first recognized in the early 1700s by de Saint-Yves, but clinical diagnosis remained elusive until Helmholtz invented the ophthalmoscope in 1851. (medscape.com)
  • Abnormal RPE cell function can lead to retinal degeneration, visual impairment and even loss of sight. (medizin-aspekte.de)
  • Inherited retinal diseases (IRDs) are a genetically heterogeneous group of blinding disorders characterized by a progressive degeneration of the photoreceptors as well as the retinal pigment epithelium (RPE). (aninews.in)
  • These studies also provide a novel view of retinal and visual function in retinal disease which should be considered when evaluating treatments involving retinal degeneration. (uleth.ca)
  • photoreceptor degeneration initially leaves the inner retinal circuitry intact and new photoreceptors need only make single, short synaptic connections to contribute to the retinotopic map. (semanticscholar.org)
  • It is shown that host cells are labelled with the donor marker through cytoplasmic transfer, and the occurrence of Cre-Lox recombination between donor and host photoreceptors is detected, which may provide alternate therapeutic strategies at earlier stages of retinal degeneration. (semanticscholar.org)
  • All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. (elsevier.com)
  • Glaucoma in general is more than a single disease entity: it is a group of conditions characterized by progressive optic nerve degeneration (detectable by pathological cupping of the optic disc) and loss of visual function, ultimately resulting in total blindness. (europa.eu)
  • According to available evidence, none of the organic eye diseases such as glaucoma, cataract, retinal degeneration and other such conditions are affected by the use of the eyes in poor light. (cdc.gov)
  • This is either an age-related or disease-induced degeneration of the macula (the part of the eye that processes central vision). (myvision.org)
  • Microglia relate to many diseases, such as diabetic retinopathy, glaucoma, and optic nerve injury. (frontiersin.org)
  • Retinal microglia are involved in the pathogenesis of inflammatory ocular diseases, such as diabetic retinopathy, glaucoma, and optic nerve injury. (frontiersin.org)
  • Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. (elsevier.com)
  • Secondary NVG, the major cause of which is iCRVO, is a very aggressive, rare form of glaucoma, responsible for 3.9 % of glaucoma cases, but contributing disproportionately to blindness from all eye diseases. (europa.eu)
  • With more than 150 million affected people, retinal degenerative diseases are one of the most frequent causes of visual impairment worldwide. (medizin-aspekte.de)
  • The McPherson Eye Research Institute and the Wisconsin Council of the Blind & Visually Impaired are teaming up to bring you an engaging program on retinitis pigmentosa (RP) and other inherited retinal degenerative diseases, live-streamed on Zoom. (wcblind.org)
  • Inherited retinal diseases (IRDs) are a diverse set of Mendelian disorders that are a major cause of inherited blindness across the world. (bmj.com)
  • Currently, there are no effective treatments for these devastating diseases, which commonly result in blindness . (aninews.in)
  • A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy. (nih.gov)
  • Photoreceptor loss causes irreversible blindness in many retinal diseases. (semanticscholar.org)
  • Both of these diseases may lead to blindness if left untreated. (eyetx.com)
  • A retinal detachment is a very serious problem that usually causes blindness unless treated. (southeasternretina.com)
  • Retinal disease, also called retinal disorders, affect this vital tissue which affects vision and, in serious cases, can cause blindness. (chatswoodeye.com)
  • Retinal diseases are significant causes of blindness and vision loss and they take the second place in the structure of disabilities due to blindness in Russia. (idmz.ru)
  • Poodles are more prone to Blindness, epilepsy and Progressive Retinal Atrophy than other breeds. (omlet.us)
  • AMD, a retinal disease causing severe and irreversible vision loss, is a major cause of blindness in individuals older than 55 years. (pharmaceuticalprocessingworld.com)
  • The aim of this narrative review is to describe the mechanisms of retinal oxidative stress and summarize the current available evidence for antioxidants as a treatment for vitreoretinal disorders. (dovepress.com)
  • Background Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous set of disorders, for which diagnostic second-generation sequencing (next-generation sequencing, NGS) services have been developed worldwide. (bmj.com)
  • This program provides comprehensive training in the evaluation, diagnosis and management of patients-both children and adults-with a broad array of inherited eye disorders including inherited retinal and macula degenerations, genetic syndromes, and metabolic diseases that affect the eye, as well as autoimmune retinopathies and other phenocopies of inherited retinal diseases. (duke.edu)
  • Retinal disorders affect this vital tissue. (medlineplus.gov)
  • The authors of these studies primarily considered the lifetime risk of ICH, and many bleeding disorders, such as von Willebrand disease (vWD), have no specific published data regarding prevalence of ICH. (cdc.gov)
  • More than 1,000 ophthalmologists from India and abroad attended the meet to share knowledge about the latest advancements in the diagnosis and management of vitreo-retinal disorders. (thenewswingz.com)
  • To evaluate the manifestations of sickle cell disease on the orofacial complex through a review of current literature concerning prevalence of dental caries, periodontal disease, temporomandibular joint disorders and radiographic alterations of maxillofacial bones. (bvsalud.org)
  • Sickle cell disease (SCD) includes genetic blood disorders in which morphologic alterations of erythrocytes are caused by presence of the sickle hemoglobin (HbS). (bvsalud.org)
  • We report the clinical and electrophysiologic findings in three patients with Bietti's crystalline corneal-retinal dystrophy. (elsevier.com)
  • therefore, we investigated the prevalence among 33 patients with retinal vein and artery occlu- sions and 80 controls. (who.int)
  • Antinuclear antithrombin, protein C, protein S or pres- antibodies were investigated with standard- ence of antiphospholipid antibodies, are ized enzyme-linked immunosorbent assay common in patients with retinal vein occlu- sions and may contribute to the etiology of (ELISA). (who.int)
  • This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. (dovepress.com)
  • Ali and colleagues characterize the differentiation of cone photoreceptors in mESC retinal organoids, showing substantial numbers of committed cone precursors. (cell.com)
  • This process, known as phagocytosis, is essential for visual function and survival of our light sensitive retinal neurons, called photoreceptors. (medizin-aspekte.de)
  • The emerging therapies from Bionic Sight and GenSight are designed to enable retinal ganglion cells to respond to light, so they can work like a back-up system for photoreceptors, the cells that normally make vision possible. (fightingblindness.org)
  • Ganglion cells often survive after photoreceptors are lost to advanced retinal disease. (fightingblindness.org)
  • Two groups are working on optogenetic therapies designed to resurrect dormant cone photoreceptors in people with advanced retinal disease. (fightingblindness.org)
  • There is a critical need for new therapies that treat a variety of serious diseases of the eye," says Peter J. McDonnell, director of the Wilmer Eye Institute and professor of ophthalmology at the Johns Hopkins University School of Medicine. (news-medical.net)
  • The Wilmer Eye Institute's deep understanding of eye disease biology and patient care and Bayer's expertise in drug discovery and development in ophthalmology complement each other perfectly. (news-medical.net)
  • However, India suffers from an acute shortfall of skilled experts in retinal ophthalmology. (thenewswingz.com)
  • To further investigate their morphology and functions in vitro , a reliable culture procedure of primary human retinal microglia is necessary. (frontiersin.org)
  • Transforming growth factor-beta1 induces alpha-smooth muscle actin expression and fibronectin synthesis in cultured human retinal pigment epithelial cells. (medscape.com)
  • Small areas of balloon-like swelling in the retina's tiny blood vessels, called microaneurysms, occur at this earliest stage of the disease. (kelliseyeandlasercenter.com)
  • This is a disease of the eyes in which the blood vessels become damaged due to elevated blood sugar associated with diabetes . (myvision.org)
  • In essence, we trained a computer to identify subtle abnormalities in retinal blood vessels from thousands of images of premature infant retinas. (nih.gov)
  • Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy. (medscape.com)
  • Researchers found that over 10 years, 89% of patients needed PRP after initial complete RPR, and approximately 33% and 16% required retinal surgery and intravitreal injection, respectively, with men (74.5%) at a significantly higher risk for needing vitreous surgery. (ophthalmology360.com)
  • In this study, subjects (eyes) will be recruited and divided into 4 groups, i.e. normal, cataract, significant refractive errors and retinal diseases. (who.int)
  • It is known to believe that smoking causes cataract by altering the structure of the retinal cells through oxidation. (thescholartimes.com)
  • Serious adverse events were rare and often related to the injection procedure including endophthalmitis (severe inflammation of the interior of the eye), intraocular inflammation, retinal detachment, retinal tear, increased eye pressure and traumatic cataract. (pharmaceuticalprocessingworld.com)
  • Dr Gunn specialises in medical and surgical diseases of the cornea, routine and complex cataract surgery and laser and refractive eye surgery. (optometryqldnt.org.au)
  • Today, with the advent of scleral buckling and small-gauge pars plana vitrectomy, in addition to laser and cryotherapy techniques, rapid ED diagnosis and treatment of a retinal detachment truly can be a vision-saving opportunity. (medscape.com)
  • They keep retinal homeostasis via regulating intra-retinal cell contacts and cytokine secretions from neurons and retinal pigment epithelium ( Langmann, 2007 ). (frontiersin.org)
  • Components (neurons, retinal pigment epithelium [RPE], glia) may be produced separately or dissociated and recombined (1) if protocol addresses a significant biological or technical hurdle and (2) if in the process of re-assembly, specific functions/roles of cell types are delineated. (nih.gov)
  • The doctor prefers the ophthalmoscope because it gives a comprehensive view to provide any particular details like retinal holes or detachments that may be a cause for alarm. (eyetx.com)
  • Results of vitrectomy for diabetic traction retinal detachments using the en bloc excision technique. (medscape.com)
  • Tragically, retinal detachments were uniformly blinding until the 1920s when Jules Gonin, MD, pioneered the first repair of retinal detachments in Lausanne, Switzerland. (medscape.com)
  • We will leverage our extensive expertise to expedite ThKanapherapeutics' success in bringing advanced treatments for retinal disease to address the unmet medical needs of patients. (biospectrumasia.com)
  • The visual adaptation model was developed to provide a novel approach for testing potential treatments for retinal disease, and the work in this thesis provides empirical support for this model. (uleth.ca)
  • The goal of the strategic research alliance is to accelerate the translation of innovative approaches from the laboratory to the clinic, ultimately offering patients new treatment options for several retinal diseases. (news-medical.net)
  • Eskies are prone to hip dysplasia, progressive retinal atrophy, Legg-Calve-Perthes disease, and juvenile cataracts, to name a few. (spendonpet.com)
  • Production of platelet-derived growth factor by interleukin-1 beta and transforming growth factor-beta-stimulated retinal pigment epithelial cells leads to contraction of collagen gels. (medscape.com)
  • Immunohistochemical analysis showed DRAM2 localization to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells where it might be involved in the process of photoreceptor renewal and recycling to preserve visual function. (ox.ac.uk)
  • Twenty-seven-gauge vitrectomy for combined tractional and rhegmatogenous retinal detachment involving the macula associated with proliferative diabetic retinopathy. (medscape.com)
  • IRDs are clinically heterogeneous and vary widely in their severity, age of onset, pathogenesis, manner of disease progression and inheritance pattern. (bmj.com)
  • Washington [US], September 25 (ANI): Researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs). (aninews.in)
  • The paper describes current preclinical successes and clinical genome editing approaches for treating inherited retinal degenerative disease and stresses there is hope that in vivo gene editing will be the future treatment paradigm for IRDs. (aninews.in)
  • Purpose: Part of the hidden genetic variation in heterogeneous genetic conditions such as inherited retinal diseases (IRDs) can be explained by copy-number variations (CNVs). (uni-koeln.de)
  • Despite the fact that the macula takes up only 3% of the retinal surface area, it is responsible for all detailed vision, such as reading, artwork, seeing the face of a clock, etc. (rieyeinstitute.com)
  • Vitrectomy for diabetic traction retinal detachment involving the macula. (medscape.com)
  • Results and prognostic factors in vitrectomy for diabetic traction retinal detachment of the macula. (medscape.com)
  • We report 4 patients with retinal hemorrhages that developed during hospitalization for de ngue fever. (cdc.gov)
  • When a patient is diagnosed with retinal detachment, it requires immediate medical attention, usually including immediate surgery to preserve eyesight. (eyetx.com)
  • Other retinal diseases require surgery. (rieyeinstitute.com)
  • Retinal surgery is usually done in a hospital operating room with a local anesthetic. (rieyeinstitute.com)
  • Sometimes retinal surgery is required. (rieyeinstitute.com)
  • Outcomes of 27 Gauge Microincision Vitrectomy Surgery for Posterior Segment Disease. (medscape.com)
  • Speaking on the occasion, Prof. Dr Amar Agarwal, Chairman, Dr Agarwal's Eye Hospitals, said: "The 12th edition of RETICON was a great success, with around 1,000 eye surgeons from India and abroad participating to discuss the latest innovations in vitreo-retinal surgery. (thenewswingz.com)
  • The clinical presentation of rare retinal diseases is often not described in the literature in detail using state of art phenotyping, although this is performed on daily basis in retinal clinics. (hra.nhs.uk)
  • In 2008, two groups of researchers reported restoring some vision in people with a rare retinal disease . (wordpress.com)
  • The diagnosis of retinal hemorrhage was made by an ophthalmologist after dilated fundoscopic examination. (cdc.gov)
  • Patients with a suspicion of retinal disease, undergoing eye examination and optical coherence tomography (OCT) scans, will be recruited across 24 optometry practices in the UK. (city.ac.uk)
  • A retinal examination is the only way to properly diagnose retinal problems. (rieyeinstitute.com)
  • A Pearson χ 2 test compared differences between men and women in whether they received a glycated hemoglobin A 1c (HbA 1c ) test in previous 6 months, a low-density lipoprotein cholesterol test in previous year, and a retinal examination in previous year. (cdc.gov)
  • A retinal examination, or a funduscopy, checks for eye diseases. (cdc.gov)
  • Doctors use specific procedures, with the help of specialized instruments, to diagnose retinal diseases, particularly retinal detachment. (eyetx.com)
  • This week Neurology News Network covered the long-term extension results of bimagrumab in patients with sporadic inclusion body myositis, data examining the history of abuse and its association with greater migraine-related sensory hypersensitivity symptoms, and the use of retinal biomarkers in vivo Alzheimer disease. (neurologylive.com)
  • Anyone experiencing the symptoms of a retinal detachment should call the office immediately at 440-285-2020. (kelliseyeandlasercenter.com)
  • What are the symptoms of Stargardt's disease? (moviecultists.com)
  • How do you deal with complex clinical manifestations of conditions, such as signs (visually observable patient abnormalities), symptoms (abnormal perceptions of illness that only the patients can report, such as pain, itching, fatigue, depressive feelings), and syndromes (clusters of signs, symptoms, and other clinical phenomena that may or may not be indicative of a specific underlying disease)? (cdc.gov)
  • Fortunately, most people who carry the Toxoplasma gondii parasite don't develop the symptoms of the disease it can cause. (medicalxpress.com)
  • These diseases may go unnoticed for a long time, as some of them show no symptoms in early stages. (thenewswingz.com)
  • The SC disease is the most second common manifestation of SCD, presenting less severe symptoms 4 , and is characterized by heterozygosis of two mutant hemoglobins, HbS and HbC (SC genotype). (bvsalud.org)
  • In sickle cell trace, the heterozygosis for genes of normal (HbA) and mutant (HbS) hemoglobins (AS genotype) does not exhibit clinical symptoms of the disease under physiological conditions 3,5 . (bvsalud.org)
  • Results: This showed that the retinal changes observed in the preeclamptic women were associated with their age (P = 0.009), gestational age (P = 0.044), blood pressure (P = 0.001), Proteinuria (P = 0.001), Severity of the disease (P = 0.001), visual acuity (P = 0.035) as well as with the visual symptoms (P = 0.001) but not statistically significant with the gravida (P = 0.799). (bvsalud.org)
  • Diseases may include diabetic retinopathy and retinal detachment. (eyetx.com)
  • Patients with any levels of diabetic retinopathy should have retinal examinations at least once every year (3). (cdc.gov)
  • O'Hare JP, Hopper A, Madhaven C, Charny M, Purewell TS, Harney B, Griffiths J. Adding retinal photography to screening for diabetic retinopathy: a prospective study in primary care. (bvs.br)
  • Owens DR, Gibbins RL, Lewis PA, Wall S, Allen JC, Morton R. Screening for diabetic retinopathy by general practitioners: ophthalmoscopy or retinal photography as 35 mm colour transparencies? (bvs.br)
  • Stem-cell-based therapies for retinal disease are gaining momentum, and clinical trials are currently being conducted in different parts of the world. (cell.com)
  • These are to be achieved using novel non-invasive techniques to assess structural and functional changes in different models of disease and their treatment, with a view to offering quick and effective translation to the clinical arena. (ucl.ac.uk)
  • Hence, the aim of this project is to establish a database to be able to provide detailed clinical information on rare eye diseases - single cases or where possible case series. (hra.nhs.uk)
  • 144 potentially disease-causing mutations were identified as novel at the time of clinical analysis, and we further demonstrate the segregation of known disease-causing variants among individuals with IRD. (bmj.com)
  • Methods: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). (elsevier.com)
  • The candidate will learn the approach to patients and families and individuals with genetic diseases, methods of clinical molecular diagnosis, genetic counseling, visual electrophysiology, and psychophysics. (duke.edu)
  • The fellow will also have the opportunity to be engaged in clinical and/or basic-science research projects related to inherited retinal diseases and teaching opportunities. (duke.edu)
  • METHODS AND ANALYSIS: The HERMES study (Teleophthalmology-enabled and artificial intelligence-ready referral pathway for community optometry referrals of retinal disease: a cluster randomised superiority trial with a linked diagnostic accuracy study) is a cluster randomised clinical trial for evaluating the effectiveness of a teleophthalmology referral pathway between community optometry and HES for retinal diseases. (city.ac.uk)
  • Each of these articles explores different data sources, and despite the variation in disease and condition combinations selected, these articles show the ability of many US federal datasets to address and better characterize the scope of MCC as well as incorporate important MCC-related issues such as the effect of MCC on the cost of clinical care and the extent of clinical care use. (cdc.gov)
  • Clinical infectious diseases: an official publication of the Infectious Diseases Society of America vol 6: 1491-8. (scholarena.co)
  • Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, ciac297. (scholarena.co)
  • 1, 2, 3, 20 Numerous clinical trials have recently been completed (though not yet published) in evaluating the safety and efficacy of NAD+ treatment of human diseases and aging. (galleriamedpharmacy.com)
  • Besides the subjectivity inherent to this way to collect data, the clinical course of a disease may be different for some patients with the same diagnosis. (vin.com)
  • That's because imaging is so crucial to disease diagnosis and clinical outcome data are so readily available. (nih.gov)
  • The RETICON conference aims to plug this gap by making the latest advancements and innovations available to all retinal surgeons to improve clinical outcomes. (thenewswingz.com)
  • Once trumpeted as a possible panacea for diseases ranging from sickle cell anemia to cystic fibrosis, gene therapy faced serious questions after the high-profile death of an Arizona teenager in a clinical trial in 1999. (wordpress.com)
  • Algic crises is the most common and important clinical symptom of this disease 9 . (bvsalud.org)
  • The Johns Hopkins University and Bayer HealthCare have entered into a five-year collaboration agreement to jointly develop new ophthalmic therapies targeting retinal diseases. (news-medical.net)
  • There are currently no effective therapies to prevent or cure these diseases. (medizin-aspekte.de)
  • The goal of the CRTD is to explore the body's self-healing potential and to develop completely new, regenerative therapies for hitherto incurable diseases. (medizin-aspekte.de)
  • Early, encouraging results from two human studies - trials launched by Bionic Sight and GenSight - are putting optogenetic therapies in the spotlight for patients with advanced vision loss from retinal conditions. (fightingblindness.org)
  • The established model used for evaluating potential therapies for retinal disease has significant limitations. (uleth.ca)
  • Specifically, we evaluated two potential therapies for retinal degenerative disease and examined their effects on vision and retinal anatomy. (uleth.ca)
  • While effective, these therapies do not fully address the complex pathology that leads to progression of these retinal diseases. (aeriepharma.com)
  • The finding of retinal drusen in IgA glomerulonephritis is consistent with complement activation and represents a model for better understanding glomerular immune deposition and a supporting argument for treatment with anti- complement therapies . (bvsalud.org)
  • Solutions presented should have a sustained, powerful influence on the understanding of retinal diseases and accelerating research toward new therapies. (nih.gov)
  • The surgical objective is to enable retinal conformation to the retinal pigment epithelium (RPE). (medscape.com)
  • Elevated levels of "free" or loosely bound metal ions can exert toxic effects, and in order to maintain homeostatic levels to protect retinal cells from their toxicity, appropriate mechanisms exist such as metal transporters, chaperones, and the presence of certain storage molecules that tightly bind metals to form nontoxic products. (jostchemical.com)
  • The whole procedure started with removing the retinal vessels, mechanical separation and enzymatic dissociation, filtration, and centrifugation. (frontiersin.org)
  • Finally, image analyses tools and biomorphometric methods were developed and refined to better quantify and stage the disease by the evaluation of vessels in images. (europa.eu)
  • The Retinal Disease Therapeutics Market Report 2018 is an in depth study analyzing the current state of the Retinal Disease Therapeutics Market. (mynewsdesk.com)
  • Finally, this IRD-oriented CNV study can serve as a paradigm for other genetically heterogeneous Mendelian diseases with hidden genetic variation. (uni-koeln.de)
  • Retinal dystrophies are an overlapping group of genetically heterogeneous conditions resulting from mutations in more than 250 genes. (ox.ac.uk)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • If walrus is in your dinner plans, the Centers for Disease Control and Prevention recommends you make sure it's well done. (medicalxpress.com)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Alzheimer's disease (AD) is the most common cause of dementia and affects millions of people worldwide. (uwaterloo.ca)
  • Perceiving collision impacts in Alzheimer's disease: the effect of retinal eccentricity on optic flow deficits. (bvsalud.org)
  • Low NAD+ levels have been linked to several conditions associated with free radical damage, including diabetes, 8 heart disease, 7, 9 vascular dysfunction, 10 ischemic brain injury, 11 Alzheimer's disease, 12, 13 and vision loss. (galleriamedpharmacy.com)
  • Several genes that were specifically expressed in particular retinal circuit elements, such as inhibitory neuron types, are associated with eye diseases. (ista.ac.at)
  • The Global Retinal Disease Therapeutics Market size is expected to reach around USD 18,845.6 Million by 2026 and growing at CAGR above 6.9% over the forecast time frame 2019 to 2026. (mynewsdesk.com)
  • The study on Retinal Disease Therapeutics Market provides analysis of China market covering the industry trends, recent developments in the market and competitive landscape. (mynewsdesk.com)
  • Research study on Retinal Disease Therapeutics Market also discusses the opportunity areas for investors. (mynewsdesk.com)
  • Retinal Disease Therapeutics Market Research report includes analysis of key market players. (mynewsdesk.com)
  • It sets down shares of each player inside the Retinal Disease Therapeutics market, growth rate and market appeal in various regions/end users. (mynewsdesk.com)
  • Our meticulous study on Retinal Disease Therapeutics Market assists a user to make a convenient decision as a means to extend their market presence and boost their market share. (mynewsdesk.com)
  • The report provides detailed profiles of the major players to bring out a clear view of the competitive landscape of the Retinal Disease Therapeutics Market. (mynewsdesk.com)
  • The report provides exhaustive market share evaluation of the global Retinal Disease Therapeutics Market based on leading manufacturers. (mynewsdesk.com)
  • A section of this report highlights country-wise global Retinal Disease Therapeutics market. (mynewsdesk.com)
  • The report on Retinal Disease Therapeutics mentions key developments and activities executed by leading service providers operating in the market. (mynewsdesk.com)
  • To comprehend and provide actionable insights in the global Retinal Disease Therapeutics market, the VRR report is categorized into various sections: market analysis by ingredients, source, application, and region. (mynewsdesk.com)
  • The report evaluates the global Retinal Disease Therapeutics market with respect to market value (US$ Mn) and volume (MT). (mynewsdesk.com)
  • The overviews, SWOT analysis and strategies of each vendor in the Retinal Disease Therapeutics market provide understanding about the market forces and how those can be exploited to create future opportunities. (mynewsdesk.com)
  • Competitive study of the major Retinal Disease Therapeutics market players will help in analyzing the market driving and business strategies. (mynewsdesk.com)
  • Samsung Biologics and Kanaph Therapeutics have entered into a strategic partnership to develop KNP-301, a bi-specific Fc fusion protein intended to treat retinal diseases. (biospectrumasia.com)
  • According to Kanaph Therapeutics, KNP-301 is designed to target autoimmune diseases by inhibiting the alternative pathway of the complement system. (biospectrumasia.com)
  • Therefore, to realize the potential promise of small molecule therapeutics for retinal diseases, the challenge of delivering them to the back of the eye must be overcome. (aeriepharma.com)
  • Off-cone), and Retinal Ganglion Cells (identify at least three subtypes). (nih.gov)
  • And, they're gene-agnostic, designed to work independent of the mutated gene causing the patient's retinal disease. (fightingblindness.org)
  • The patient's disease progressed greatly from the age of 36 to 47 years. (elsevier.com)
  • Surgical outcomes of 25-gauge pars plana vitrectomy for diabetic tractional retinal detachment. (medscape.com)
  • Long-term outcomes of sutureless 25-G+ pars-plana vitrectomy for the management of diabetic tractional retinal detachment. (medscape.com)
  • Copper deficiency is associated with optic neuropathy, but retinal function is maintained. (jostchemical.com)
  • The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. (elsevier.com)
  • Fundoscopy typically reveals severe tortuosity, engorgement of retinal veins, deep haemorrhages, cotton wool spots and optic disc swelling . (moviecultists.com)
  • Whether this is mediated by small- or large-artery disease is unknown. (elsevier.com)
  • each standard deviation decrease in large-artery compliance was associated with a 0.70μm (p = 0.002) decrease in retinal arteriolar caliber. (elsevier.com)
  • each standard deviation decrease in small artery compliance was associated with a 1.43μm (p = 0.001) increase in retinal venular caliber. (elsevier.com)
  • In 50% of the cases, cartoid artery disease is present. (southeasternretina.com)
  • People who have RVO have an increased risk of other cardiovascular diseases (including stroke, heart attack, heart failure, and peripheral artery disease) and death. (vision-relief.com)
  • The key areas of research include haematology and immunology, diabetes, neurodegenerative diseases and bone regeneration. (medizin-aspekte.de)
  • The trials include one for a rare, genetic immune system disease called Wiskott-Aldrich syndrome and another scheduled to begin this summer for the neurodegenerative disease adrenoleukodystrophy, best known from the role it played in the movie "Lorenzo's Oil. (wordpress.com)
  • Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high metabolic demand. (dovepress.com)
  • Besides, due to their close relationship with blood-derived immunocytes and macroglia, retinal microglia can initiate inflammatory responses to defend microorganisms and lead to tissue injuries by releasing proinflammatory cytokines, reactive oxygen species (ROS), and reactive nitrogen species (RNS). (frontiersin.org)
  • Retinal diseases are diseases that impact the light-sensitive tissue located at the back side of the eye. (eyetx.com)
  • In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells were cultured within a three-dimensional microfluidic device, and cell responses at the tissue level to changes in the microenvironment were analyzed. (nii.ac.jp)
  • 5-7 In these states, the oxidative imbalance between formation and clearance of ROS has been implicated in disease progression and impairing survival signaling. (dovepress.com)
  • Preventing or slowing the progression of such disease depends ultimately on the patient. (cdc.gov)
  • Lucentis is designed to block new blood vessel growth and leakiness, which ultimately lead to disease progression and such vision loss. (pharmaceuticalprocessingworld.com)
  • Zolgensma is designed to address the genetic root cause of SMA by providing a functional copy of the human SMN gene to halt disease progression through sustained SMN protein expression with a single, one-time intravenous (IV) infusion. (genetherapynet.com)
  • Two brothers had regional involvement of the posterior pole with disturbances of retinal function attributable to localized disease, and there was only mild progression in these patients. (elsevier.com)
  • Conclusion: Our study highlights the importance of timely ophthalmoscopy which helps to assess severity of disease (pre-eclampsia) which affects the decision of induction of delivery to predict and prevent possible complications which in turn immensely helps in judicious management of disease. (bvsalud.org)
  • Harding SP, Broadbent DM, Neoh C, White MC, Vora J. Sensitivity and specificity of photography and direct ophthalmoscopy in screening for sight threatening eye disease: the Liverpool Diabetic Eye Study. (bvs.br)
  • In fact, 2.2% of people 65 years or older have severe vision problems from the disease. (rieyeinstitute.com)
  • Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
  • The aim of this research was to establish a new method to classify dogs in healthy or heart diseased (chronic degenerative mitral valve disease--CDMVD) in mild, moderate and severe, considering echocardiographic parameters. (vin.com)
  • The initial evaluation in one patient demonstrated diffuse disease involving retinal pigment epithelium and choriocapillaris with severe widespread disturbance of retinal function. (elsevier.com)
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • We also observed a robust response of retinal microglia in lipopolysaccharide (LPS) treatment with proinflammatory cytokines. (frontiersin.org)
  • With a large proportion of patients referred to Hospital Eye Services (HES) for diagnostics and disease management, the referral process results in unnecessary referrals from erroneous diagnoses and delays in access to appropriate treatment. (city.ac.uk)
  • This is important in the treatment of cardiovascular diseases in the aging population. (hopkinsmedicine.org)
  • This is a health issue because a disease can progress without early detection, proper diagnosis, treatment, and full commitment of the patient. (cdc.gov)
  • This would be the first non-invasive treatment for this disease. (europa.eu)
  • Moreover, even laser treatment does not cure the disease. (europa.eu)
  • With rapid medical advances related to retinal diseases, their management and treatment are becoming much more affordable and effective. (thenewswingz.com)
  • The early treatment helps to cure the diseases otherwise the victim loses their vision. (marketdensity.com)
  • The advanced technological solutions enable Optometrists and Ophthalmologists to detect eye disease in the early stage to provide appropriate treatment. (marketdensity.com)
  • To evaluate the red reflex of newborns, percentage of ocular diseases resulting in red reflex abnormality, and their relation with consanguinity in Southeast Turkey. (who.int)
  • Any transmission block at any part of the optical pathway of consanguinity and ocular diseases will be helpful in results in reflex abnormality that includes its absence, informing the public about risks of intermarriages. (who.int)
  • P- = .007) and retinal nerve fiber layer thickness (RNFL-T), particularly in the inferior quadrant. (neurologylive.com)