A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night blindness and progressive contraction of the visual field.
Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.
Recording of electric potentials in the retina after stimulation by light.
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
A rare degenerative inherited eye disease that appears at birth or in the first few months of life that results in a loss of vision. Not to be confused with LEBER HEREDITARY OPTIC NEUROPATHY, the disease is thought to be caused by abnormal development of PHOTORECEPTOR CELLS in the RETINA, or by the extremely premature degeneration of retinal cells.
A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age.
The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)
Type III intermediate filament proteins expressed mainly in neurons of the peripheral and CENTRAL NERVOUS SYSTEMS. Peripherins are implicated in neurite elongation during development and axonal regeneration after injury.
Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.
The blood vessels which supply and drain the RETINA.
Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2.
Devices for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth. (UMDNS, 1999)
Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.
A group of disorders involving predominantly the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the RETINA; RETINAL PIGMENT EPITHELIUM; BRUCH MEMBRANE; CHOROID; or a combination of these tissues.
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.
The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
Examination of the interior of the eye with an ophthalmoscope.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
The macroglial cells of EPENDYMA. They are characterized by bipolar cell body shape and processes that contact BASAL LAMINA around blood vessels and/or the PIA MATER and the CEREBRAL VENTRICLES.
The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; OPTIC NERVE DISEASES; OPTIC CHIASM diseases; or BRAIN DISEASES affecting the VISUAL PATHWAYS or OCCIPITAL LOBE.
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Nerve cells of the RETINA in the pathway of transmitting light signals to the CENTRAL NERVOUS SYSTEM. They include the outer layer of PHOTORECEPTOR CELLS, the intermediate layer of RETINAL BIPOLAR CELLS and AMACRINE CELLS, and the internal layer of RETINAL GANGLION CELLS.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
A group of rare, idiopathic, congenital retinal vascular anomalies affecting the retinal capillaries. It is characterized by dilation and tortuosity of retinal vessels and formation of multiple aneurysms, with different degrees of leakage and exudates emanating from the blood vessels.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.
An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)
A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.
Defects of color vision are mainly hereditary traits but can be secondary to acquired or developmental abnormalities in the CONES (RETINA). Severity of hereditary defects of color vision depends on the degree of mutation of the ROD OPSINS genes (on X CHROMOSOME and CHROMOSOME 3) that code the photopigments for red, green and blue.
Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.
Neurons of the innermost layer of the retina, the internal plexiform layer. They are of variable sizes and shapes, and their axons project via the OPTIC NERVE to the brain. A small subset of these cells act as photoreceptors with projections to the SUPRACHIASMATIC NUCLEUS, the center for regulating CIRCADIAN RHYTHM.
Method of measuring and mapping the scope of vision, from central to peripheral of each eye.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
The administration of substances into the eye with a hypodermic syringe.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).
Genes that influence the PHENOTYPE only in the homozygous state.
Biochemical identification of mutational changes in a nucleotide sequence.
The total area or space visible in a person's peripheral vision with the eye looking straightforward.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Diseases affecting the eye.
A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. Low vision generally refers to visual disorders that are caused by diseases that cannot be corrected by refraction (e.g., MACULAR DEGENERATION; RETINITIS PIGMENTOSA; DIABETIC RETINOPATHY, etc.).
Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Method of making images on a sensitized surface by exposure to light or other radiant energy.
An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Transport proteins that carry specific substances in the blood or across cell membranes.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
Introduction of substances into the body using a needle and syringe.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Any method used for determining the location of and relative distances between genes on a chromosome.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light. (1/1813)

The photopathology of retinal lesions produced by extended exposure (1000 sec) to low corneal power levels (62 microW) of blue light (441 nm) was investigated by light microscopy in 20 rhesus eyes over an interval ranging from 1 hr to 90 days after exposure. Results indicate a nonthermal type of photochemical lesion originating in the retinal pigment epithelium and leading to a histological response with hypopigmentation which requires 48 hr to appear. This type of lesion helps to explain solar retinitis and eclipse blindness and has significance for aging and degenerative changes in the retina.  (+info)

Pigment epithelial windows and drusen: an animal model. (2/1813)

Aging rhesus monkeys, both controls and those undergoing long-term administration of investigational oral contraceptive steroids, developed widespread hyperfluorescent dots at the posterior pole. The dots were considered to represent drusen. Histologic (including electron microscopic) study showed the "drusen" in some of the animals to be almost exclusively pigment epithelial windows produced by a lipoidal degeneration of the pigment epithelial cells. The experiment provided a fortuitous model for direct correlation of clinical and histologic observations of myriad uniform, tiny, depigmented, hyperfluorescent, nonleaking spots at the level of the retinal pigment epithelium.  (+info)

Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. (3/1813)

PURPOSE: Accumulated evidence has shown that apoptosis and necrosis contribute to neuronal death after ischemia. The present study was performed to study the temporal and spatial patterns of neuronal necrosis and apoptosis after ischemia in retina and to outline mechanisms underlying necrosis and apoptosis. METHODS: Retinal ischemia was induced by increasing intraocular pressure to a range of 160 mm Hg to 180 mm Hg for 90 minutes in adult rats. The patterns of neuronal cell death were determined using light and electron microscopy and were visualized by TdT-dUTP nick-end labeling (TUNEL). The mRNA expression profile of p53 was examined using reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization histochemistry. Immunohistochemistry was performed using anti-p53, anti-microtubule associated protein-2, and anti-glial fibrillary acidic protein antibodies. RESULTS: Within 4 hours after ischemia, neurons in the inner nuclear cell layer (INL) and ganglion cell layer (GCL) underwent marked necrosis, made apparent by swelling of the cell body and mitochondria, early fenestration of the plasma membrane, and irregularly scattered condensation of nuclear chromatin. After 3 days, the INL and GCL neurons showed further degeneration through apoptosis marked by cell body shrinkage, aggregation, and condensation of nuclear chromatin. Apoptotic neurons were also observed sparsely in the outer nuclear cell layer. Intravitreal injections of MK-801 prevented early neuronal degeneration after ischemia. Of note, mRNA and protein levels of p53, the tumor suppressor gene known to induce apoptosis, were increased in the retinal areas undergoing apoptosis 1 to 3 days after ischemic injury. CONCLUSIONS: Ischemia produces the N-methyl-D-aspartate-mediated necrosis and slowly evolving apoptosis of neurons in the retina. The latter may depend on the expression of the p53 proapoptosis gene.  (+info)

Idiopathic central serous chorioretinopathy. (4/1813)

Idiopathic central serous chorioretinopathy (ICSC) is usually seen in young males with Type A personality. Clinical evaluation of the macula with fundoscopy and biomicroscopy, coupled with fluorescein angiography establishes the diagnosis. Indocyanine green angiographic studies have reinformed that the basic pathology lies in choriocapillaries and retinal pigment epithelium. Most of the ICSC resolve completely in four months, and some of them could resolve early with direct photocoagulation of the leaking site. Oral steroids have no role, and could even cause an adverse reaction.  (+info)

Rapid pneumatic and Mackey-Marg applanation tonometry to evaluate the postural effect on intraocular pressure. (5/1813)

A postural study was conducted in three separate groups of subjects. The first group comprised 20 women volunteers with an average age of 20-75 years. In this group, the study was conducted by the pneumatonograph only. Mean pressure recorded was 15-65 +/- 0-25 mmHg and there was an average rise of 1-4 mmHg in supine posture. Groups 2 and 3 comprised 151 non-glaucomatous and 108 glaucomatous eyes respectively in the age range of 30 to 85 years. In these two groups, the study was conducted using the PTG and the Mackay-Marg tonometer. Clinical evaluation of the Mackay-Marg with the PTG gave significant correlation, with mean Mackay-Marg readings being 1-13 mmHg higher. The intraocular pressure when changing from seated to the supine position increased on average by 2-71 and 4-04 mmHg, respectively in Groups 2 and 3 and by 2-51 and 3-72 mmHg by Vackay-Marg, suggesting a higher change in glaucomatous subjects. Pressure on resumption of sitting was found to be lower than the initial pressure. Postural change also showed some direct relationship with age in non-glaucomatous subjects.  (+info)

Chronic retinal vein occlusion in glaucoma. (6/1813)

Asymptomatic chronic retinal vein occlusion that occurs in chronic simple glaucoma is described. The condition is characterized by marked elevation of retinal vein pressure with collateral vessels and vein loops at the optic disc in cases of central vein occlusion, or retinal veno-venous anastomoses along a horizontal line temporal and nasal to the disc in hemisphere vein occlusion. No patient had visible arterial changes, capillary closure, fluorescein leakage, or haemorrhages. The vein occlusion was not limited to "end stage" glaucoma. The role of increased intraocular pressure and glaucomatous enlargement of the optic cup with retinal vein distortion in the pathogenesis of the condition was stressed. Follow-up of these patients revealed persistence of the retinal vein occlusion shown by elevated retinal vein pressures. This would reduce effective perfusion of the inner retina and optic disc and may affect the long-term visual prognosis.  (+info)

Apoptosis and caspases after ischemia-reperfusion injury in rat retina. (7/1813)

PURPOSE: Extensive cell loss in the retinal ganglion cell layer (RGCL) and the inner nuclear layer (INL) was noted in a rat model of retinal ischemia-reperfusion injury by transient elevated intraocular pressure (IOP). The possible involvement of apoptosis and caspases was examined in this model of neuronal loss. METHODS: Transient elevated IOP was induced in albino Lewis rats through the insertion of a needle into the anterior chamber connected to a saline column. Elevated IOP at 110 mm Hg was maintained for 60 minutes. Groups of animals were euthanatized at various times after reperfusion, and their retinas were evaluated by morphology, agarose gel electrophoresis of DNA, in situ terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL), immunohistochemistry of caspases II (ICH1) and III (CPP32), and morphometry. YVAD.CMK, a tetrapeptide inhibitor of caspases, was used to examine the involvement of caspases. RESULTS: A marked ladder pattern in retinal DNA gel analysis, typical of internucleosomal DNA fragmentation and characteristic of apoptosis, was present 12 and 18 hours after reperfusion. Labeling of nuclei in the RGCL and the inner nuclear layer (INL) by TUNEL was noted between 8 and 18 hours after reperfusion. Histologic and ultrastructural features typical of apoptosis were also observed in the inner retina after ischemia. YVAD.CMK administered during the ischemic period inhibited apoptotic fragmentation of retinal DNA and ameliorated the tissue damage. When administered intravitreally 0, 2, or 4 hours after reperfusion, YVAD.CMK was also effective in preserving the inner retina but had no significant effect when administered 6 or 8 hours after reperfusion. The inner retina showed transient elevated immunoreactivity of caspases II and III 4 and 8 hours after reperfusion. CONCLUSIONS: Retinal ischemia-reperfusion after transient elevated IOP induced apoptosis of cells in the retinal ganglion cell layer and the INL. Caspases may have a pivotal role in the early events of the apoptotic pathway(s). Rescue by using anti-apoptotic agents after ischemia-reperfusion is feasible.  (+info)

Retinopathy of prematurity-mimicking retinopathy in full-term babies. (8/1813)

The purpose of this study was to analyze the fundus findings and associated abnormalities in full-term babies with retinopathy of prematurity (ROP)-mimicking retinopathy. In twenty-seven such babies suffering from this condition, retinal findings were retrospectively analyzed. These babies were not premature and had not required supplementary oxygen; there was no family history of the disease, and no known causes. Bilaterality and severity of retinopathy were compared between groups with associated systemic abnormalities and those without. Forty eyes in twenty-seven full-term babies had abnormal retinal findings; dragged retina accounted for 42.5%, and falciform retinal fold for 47.5%, and retrolental membrane for 10%. Nine babies had associated brain abnormalities, and in these, severe bilateral retinopathy was more likely to occur than in those without abnormalities. These results suggest that if full-term babies have associated abnormalities of the brain, the presence of retinopathy should be ascertained postnatally by cautious examination of the retina.  (+info)

H30.143 is a billable diagnosis code used to specify a medical diagnosis of acute posterior multifocal placoid pigment epitheliopathy, bilateral. Code valid for the fiscal year 2021
Symptoms of the following disorders can be similar to those of acute posterior multifocal placoid pigment epitheliopathy. Comparison may be useful for a differential diagnosis:. Diffuse unilateral subacute neuroretinitis (DUSN) is a progressive parasitic disease affecting the outer retina and retinal pigment epithelium (RPE). This syndrome is primarily unilateral, although bilateral cases have occurred. Examination of the eye shows visual loss, vitreous cells, optic disc inflammation and leakage, and transient, but recurrent, crops of gray-white outer retinal lesions.. Stationary or migrating parasitic worms (nematodes) have been identified deep in the retina or in the subretinal space. Later in the course of the disease, slowly progressive RPE changes and optic atrophy may be observed, as well as narrowing of the retinal vessels.. Multifocal choroidopathy syndromes are a group of rare disorders involving a major pathological change at or near the level of the retinal pigment epithelium (RPE) ...
TY - JOUR. T1 - Purtschers retinopathy associated with acute pancreatitis. AU - Hamp, Ania M.. AU - Chu, Edward. AU - Slagle, William S.. AU - Hamp, Robert C.. AU - Joy, Jeffrey T.. AU - Morris, Robert W.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/2. Y1 - 2014/2. N2 - PURPOSE: Purtschers retinopathy is a rare condition that is associated with complement-activating systemic diseases such as acute pancreatitis. After pancreatic injury or inflammation, proteases such as trypsin activate the complement system and can potentially cause coagulation and leukoembolization of retinal precapillary arterioles. Specifically, intermediate-sized emboli are sufficiently small enough to pass through larger arteries yet large enough to remain lodged in precapillary arterioles and cause the clinical appearance of Purtschers retinopathy. This pathology may present with optic nerve edema, impaired visual acuity, visual field loss, as well as retinal findings such as ...
Purpose : Split Spectrum Amplitude Decorrelation Angiography (SSADA) based Optical Coherence Tomography Angiography (OCTA) evaluation of Acute Multifocal Placoid Pigment Epitheliopathy (AMPPE). Methods : Retrospective review of SSADA based OCTA, SD-OCT and FA on patients with AMPPE, and to observe the choroidal vascular changes over the clinical course of this disease. Results : 2 patients with AMPPE were evaluated using OCTA. During the acute phase, OCTA detected no blood flow in the choriocapillaris corresponding to retinal placoid lesions on clinical exam, but there was surrounding increased flow. In addition, there were some hyporeflective areas in the RPE and outer retina corresponding to the retinal placoid lesions. There was no significant vascular flow changes in the superficial and deep retina. In the resolution stage of this disease, blood flow resumed and a pigment shadowing effect was noted. Conclusions : OCTA showed a significant deprivation of choriocapillaris blood flow in the ...
Cotton wool spots are an abnormal finding on funduscopic exam of the retina of the eye. They appear as fluffy white patches on the retina. They are caused by damage to nerve fibers and are a result of accumulations of axoplasmic material within the nerve fiber layer. There is reduced axonal transport (and hence backlog and accumulation of intracellular products) within the nerves because of the ischemia. This then causes the nerve fibers to be damaged by swelling in the surface layer of the retina. A 1981 analysis concluded that in most instances, cotton-wool spots do not represent the whole area of ischaemic inner retina but merely reflect the obstruction of axoplasmic flow in axons crossing into much larger ischaemic areas.[1] Associated findings include microvascular infarcts and hemorrhages. The appearance of cotton wool spots may decrease over time. Abundant cotton wool spots are seen in Malignant hypertension.. Diabetes and hypertension are the two most common diseases that cause these ...
Aims: To study the incidence, systemic associations, presenting features and natural history of Purtschers retinopathy in the UK and Ireland.. Methods: Cases were collected prospectively by active surveillance through the British Ophthalmological Surveillance Unit. Clinical details were obtained using an incident questionnaire, with follow-up at 1 and 6 months.. Results: Clinical details were obtained for 15 cases over 12 months. These were associated with road traffic accidents in 6 cases, chest compression in 6 cases and acute pancreatitis in 3 cases. All cases were symptomatic and presented with loss of visual acuity, visual field or a combination. Bilateral involvement was noted in 9 cases. The acute retinal signs of cotton wool spots, retinal haemorrhage and Purtscher flecken cleared within 1 month in 26% of eyes and within 6 months in all eyes. The most common chronic signs were optic disc pallor and atrophy of the retinal pigment epithelium. Without treatment, 50% of eyes improved by at ...
The U.S Food and Drug Administration in October 2017 revealed their plans to recommend gene therapy as a way to treat inherited retinal diseases. These diseases usually cause a gradual loss of sight that eventually leads to total blindness.. What are Inherited Retinal Diseases (IRDs)?. Inherited retinal diseases (IRDs) are rare eye problems that are caused by mutations that occur in the RPE65 gene. These types of gene mutations are hereditary and responsible for specific conditions that include Lebers congenital amaurosis and some forms of retinitis pigmentosa. Gene therapy can be used to treat these eye disorders.. How gene therapy can treat inherited retinal diseases. People suffering from various types of inherited retinal diseases either have genes that dont work, or are missing. Gene therapy can be used to treat these diseases by adding new genes to their cells to replace the missing or dysfunctional ones.. Usually, they use a specific prepared virus that introduces its own different ...
Cotton wool spots are yellow or white spots on the surface of the retina when the retina doesnt get enough blood. The effects of...
54-year-old woman was seen in the office on 3/25/2011. She was diagnosed as HIV positive in 1993. Her CD4 count is currently less than 50 and she was hospitalized for pneumocystis carinii pneumonia back in November of 2010. Earlier this month, on March 3rd, she had an episode where she felt strange. She dropped a smoothie and had slurred speech for about ten minutes. Her symptoms completely cleared and it was thought she had a transient ischemic attack. Since then she has had MRI and CT scans, both of which were normal, but she has noticed just for the last few weeks a few blind spots in the paracentral vision. Predominantly out of her right eye when she closes her left eye, she sees a few temporal blind spots. VISUAL ACUITY: Her vision is 20/25 in each eye. IOP: OD 11, OS 12. SLIT LAMP EXAM: Normal with clear lenses. EXTENDED OPHTHALMOSCOPY: OD: Vertical C/D ratio is 0.5. There is no posterior vitreous separation. There are cotton-wool spots predominantly superior to the optic nerve and ...
Purpose : Inherited retinal diseases (IRDs) may be caused by variations in genes affecting the connecting cilium of photoreceptor cells and the intraflagellar transport summarized as ciliopathies. CEP290 is frequently mutated in non-syndromic, but also syndromic IRDs. In preparation for clinical treatment trials detailed phenotypic work-up including longitudinal follow-up is mandatory. Methods : We performed genotype-phenotype correlations in 29 patients with biallelic mutations in CEP290. The study was approved by the IRB of the medical faculty, JLU Giessen. The patients received a comprehensive clinical examination including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) recording, and electrophysiology whenever possible. Results : We compiled data from a median age at first visit of 0.7 y and a median follow-up period of 5.1 y (range 6 m to 25.7 y). The oldest patient was 84 y at last visit ...
Hi, I donated platelets for the first time on Monday, and on Tuesday I noticed this crescent moon shadow in my left eye. I went to the opthamologist today, and she determined I had a cotton wool s...
So now that the biggest nature-themed event of 2017 is finished, we can all throw our rad NASA certified eclipse goggles into a drawer until 2024, when the next eclipse is due, and move on with our lives. Correct?. Wrong.. Nature is a cruel mistress, and if we think we can get away with a little entertainment and not pay the price, we have another thing coming to us. Over the next several days, there may be droves of patients presenting with the chief complaint of: Help, I looked at the eclipse through [a roll of toilet paper, binoculars, used film, four sets of sunglasses taped sequentially together] and now my vision is blurry, my eyes hurt, and there is a black spot in my visual field.. So, what is Solar Retinopathy? Also known as Photic Retinopathy, Foveomacular Retinitis, Solar Retinitis, or Eclipse Retinopathy, this is a disease process that has been described even by the Greeks during the Hellenic period, afflicting astronomers and sun-gazers.. This process is not a direct thermal burn, ...
In simple terms, genes are like recipes for making proteins. All the cells in our bodies read genetic information so they can make the critical proteins necessary to stay healthy and function properly. If there is a mistake in a gene - that is, a misspelling - a protein might not be made correctly and cells in the retina might degenerate and cause vision loss.. These misspellings are called mutations, and just like a mistake in a recipe, some mutations are more devastating than others. For example, when baking a cake, lets say there is an error in the recipe. It incorrectly calls for a quarter cup of sugar, when the right amount is a half of a cup. The cake may not taste great, but it is still edible. But lets say the instruction for adding flour is omitted entirely. Then the cake will be a complete failure and go uneaten.. Well, the same concept applies to genetic mutations in inherited retinal diseases. Some mutations can lead to devastating vision loss while others cause less severe, ...
The gene therapy technology already exists to treat most inherited retinal disease. The current challenge is to drive down the costs of implementing the technology.
Professor Anthony Moore, wrote an interesting article on gene testing for inherited retinal disease (IRD) in Ophthalmology, a scientific journal for eyes.
In this post, Professor Michaelides imagines a future of better retinal disease diagnostics and treatments, especially for inherited retinal diseases.
This live course is designed to provide clinicians with current information and strategies for the diagnosis and treatment of pediatric and hereditary retinal diseases. It focuses on the following topics: survey of pediatric retinal diseases and the use of gene therapy in hereditary retinal diseases. The first half of the course uses case scenarios to provide in depth knowledge of pediatric retinal diseases. It specifically addresses how to create a differential diagnosis for leukorcoria, the importance of ruling out retinoblastoma, a better understanding of retinovascular/exudative causes of pediatric retinal disease, a better understanding of hereditary vitreoretinal disorders in the pediatric population, how to differentiate congenital optic nerve head disorders and sequelae, and traumatic ocular injuries in pediatric patients. The second half of the course provides updates on current gene therapies for the treatment of hereditary retinal diseases with the potential to restore vision or slow ...
Also, exhibits, which in a medical negligence case typically involve medical records, may also be augmentin purchase into evidence and go with the jury into the jury room. L. Bruhn, W. Cotton wool spots and hemorrhages are features of retinal ischemia.
GAINESVILLE, Fla. and CAMBRIDGE, Mass. and COLUMBIA, Md., Aug. 15, 2017 (GLOBE NEWSWIRE) -- Applied Genetics Technology Corporation (NASDAQ:AGTC), a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapies for the treatment of rare diseases, and the Foundation Fighting Blindness (FFB) announced today a partnership agreement to support the organizations shared mission to advance gene therapy research to treat inherited retinal diseases.. We are grateful to AGTC for its continued support of the Foundation, says Valerie Navy-Daniels, FFBs chief development officer. AGTCs support will allow us to bring information about the advancements in treating inherited retinal diseases to more people and in doing so helps us get closer to our goal of bringing hope to people affected by these blinding conditions.. Under the terms of the agreement, AGTC will provide grant funding to support the Foundations My Retina Tracker® registry as well as a ...
Leaders in the field meet to educate physicians, researchers and the community at the 2012 Center for Vision Research Inherited Retinal Disease symposium.
Summary: The purpose of the study is to investigate the clinical effectiveness of prophylactic treatment of women who have previously undergone preeclampsia and are a part of the risk group for the formation of vascular retinal pathology. Material and Methods. The main group consisted of 40 women aged 24 to 43. The selection criterion was presence of a risk of vascular retinal pathology formation. Women of the main group were prescribed periodic courses of preventive treatment for a period of time of 3-4.5 years. The comparison group consisted of 51 women, who underwent preeclampsia, and also had a risk of forming vascular retinal pathology and did not receive preventive treatment. Results. Systematic conduct of preventive treatment courses with antiplatelet agents and antioxidants to women who have undergone preeclampsia and are at risk of vascular retinal pathology formation have been effective. Conclusion. Frequency of vascular retinal pathology formation in the main group decreased to 15% ...
A Peek Down the Pipeline: Emerging Drug-Delivery Options for Retinal Diseases Steven Yeh, MD, Thoms A. Albini, MD; and Andrew A. Moshfeghi, MD, MBA
Electrophysiologic tests are used widely in the objective functional examinations in different retinal diseases for several reasons as follows: (1) Differentiation of those diseases with similar...
Retinal Examinations for Macular Degeneration Close to 10 million people every year lose their vision as a result of the incurable eye disease, macular
The primary objective of the proposed study is to show that inhaled equimolar mixture of oxygen and nitrous oxide (EMONO) will reduce pain associated with retinal exam in the preterm infant, as compared to the current standard treatment (oral sucrose and topical anaesthesia). The investigators also aim to show that EMONO can be used safely in preterm neonates undergoing retinal exam, and will not result in any increase in apnea, bradycardia, or desaturation in the 24 hours following the exam. Finally, the investigators aim to show that EMONO will keep the infant calm, and make retinal examination easier and less traumatic. ...
A retinal disorder occurs when the retina malfunctions. The retina is the light-sensitive tissue on the inside and back of the eye.
NightstaRx announced the completion of a $45 million Series C financing transaction, the proceeds of which will be used for the upcoming phase 3 trial for Nightstars lead product candidate, NSR…
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IJEAP is an international journal that covers a wide range of the most recent and advanced research in engineering and sciences with rigorous scientific analysis.
Researchers study retinopathy as possible indicator of nephropathy... The number of diabetes mellitus cases is on the rise while the incidence of
Purpose: To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons. Design and Participants: Population-based, cross-sectional study comprising 2050 men and women aged 69 to 97 years without diabetes, living in four communities. Methods: Participants underwent retinal photography and standardized grading of retinal microvascular characteristics, including retinopathy (e.g., microaneurysms, retinal hemorrhages), focal arteriolar narrowing, and arteriovenous nicking. In addition, calibers of retinal arterioles and venules were measured on digitized photographs to obtain an estimate of generalized arteriolar narrowing. Atherosclerosis and its risk factors were obtained from clinical examination and laboratory investigations. Main Outcome Measures: Prevalence of retinal microvascular abnormalities and their associations with measures of atherosclerosis. Results: The prevalence of retinal microvascular abnormalities ...
TY - JOUR. T1 - Retinal microvascular abnormalities and blood pressure in older people. T2 - The Cardiovascular Health Study. AU - Wong, Tien Yin. AU - Hubbard, L. D.. AU - Klein, R.. AU - Marino, E. K.. AU - Kronmal, R.. AU - Sharrett, A. R.. AU - Siscovick, D. S.. AU - Burke, G.. AU - Tielsch, J. M.. PY - 2002/9. Y1 - 2002/9. N2 - Aim: To examine the relation between blood pressure and retinal microvascular abnormalities in older people. Methods: The Cardiovascular Health Study is a prospective cohort study conducted in four US communities initiated in 1989 to 1990. Blood pressure was measured according to standardised protocols at each examination. During the 1997-8 examination, retinal photographs were taken of 2405 people aged 69-97 years (2056 without diabetes and 349 with diabetes). Signs of focal microvascular abnormalities (focal arteriolar narrowing, arteriovenous nicking, and retinopathy) were evaluated from photographs according to standardised methods. To quantify generalised ...
The white dot syndromes are a group of inflammatory chorioretinopathies of unknown etiology which have in common a unique and characteristic appearance of multiple yellow-white lesions affecting multiple layers of the retina, retinal pigment epithelium (RPE), choriocapillaris, and the choroid. They also have overlapping clinical features. We discuss acute retinal pigment epitheliopathy, multiple evanescent white dot syndrome, acute posterior multifocal placoid pigment epitheliopathy, multifocal choroiditis and panuveitis, acute zonal occult outer retinopathy, birdshot chorioretinopathy, and serpiginous choroidopathy. Some of these diseases are associated with a viral prodrome suggesting a possible viral/infectious etiology, while others are associated with a number of systemic processes suggesting an autoimmune etiology. We also review the presentation, evaluation/diagnosis, and treatment of these entities as well as the prognosis. Where applicable we discuss recent advancements in diagnosing and
Is Central Serous Retinopathy (CSR) the new carpal tunnel for a generation of over-stressed and over-loaded information workers who spend far too many hours per day staring at screens of varying dimensions?. Central serous retinopathy (or choroidopathy) is essentially a delamination of the retina when cellular layers that normally serve as a fluid barrier between the choroid and the retina begin to leak. This introduces a bubble or blister of fluid underneath the retina. This results in blurred and dimmed vision.. Although CSR is idiopathic, it has been linked to chronic stress, defined biochemically as elevated serum cortisol levels. This finding is corroborated by an increased incidence of CSR in those with Cushings Syndrome (chronic overexposure to elevated levels of cortisol.) Men are more often affected than women; with an age of onset between 20-50, averaging around 45.. Ive been having progressively worse vision problems since December that I had attributed to floaters or sleep ...
Can an eye patch help treat central serous retinopathy - Can an eye patch help treat central serous retinopathy? No. Csr is typically treated with a watch and wait approach. Occasionally laser can be used to hasten the recovery. New injectable drugs are also being explored.
48-year-old man has had waxing and waning vision in the left eye for the last year from central serous retinopathy. OD is 20/16, OS is 20/16 - 2 months post PDT therapy with Visudyne ...
Purpose: Hypertension is a worldwide problem that contributes to other diseases such as cardiovascular diseases and also ocular diseases. Unfortunately, hypertensive awareness, remain less than optimal. The simplest method to determine the awareness of hypertension retinopathy can be achieve by completing questionnaire. Thus this study was conducted to identify the level of awareness of hypertensive retinopathy.Methods: Sixty four of hypertension patients 37 male and 27 female were assigned into this study where they need to answer 2 set of questionaire. All questionaires were collected as soon as subject finished answering the questions. Result: The questionaire of this research show good validity based on content and face validation done during pilot study. Overall the awareness of the hyperensive retinopathy were low with 23.4% aware about hypertensive retinopathy. Conclusion: Awareness of hypertensive retinopathy still low among hypertension patient in Selangor area. More research about this ...
To view the entire topic, please sign in or purchase a subscription. One often cited side effect is chloroquine retinopathy, which can result in permanent vision loss after high cumulative doses of chloroquine.. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and …. Abstract Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less.. Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 chloroquine retinopathy had received daily doses of 250 mg or less. In a pigmented rabbit model of chloroquine toxicity, serum hypo- and dysproteinemia developed with decreases in serum albumin and alpha 1 and 2 globulin fractions and increases in beta ...
Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure (i.e. hypertension). Most patients with hypertensive retinopathy have no symptoms. However, some may report decreased or blurred vision, and headaches. Signs of damage to the retina caused by hypertension include: Arteriolar changes, such as generalized arteriolar narrowing, focal arteriolar narrowing, arteriovenous nicking, changes in the arteriolar wall (arteriosclerosis) and abnormalities at points where arterioles and venules cross. Manifestations of these changes include Copper wire arterioles where the central light reflex occupies most of the width of the arteriole and Silver wire arterioles where the central light reflex occupies all of the width of the arteriole, and arterio-venular (AV) nicking or AV nipping, due to venous constriction and banking. advanced retinopathy lesions, such as microaneurysms, blot hemorrhages and/or flame hemorrhages, ischemic changes (e.g. cotton wool ...
What is Hypertensive Retinopathy?. Hypertensive retinopathy is a condition of retinal vascular changes that occur as a result of prolonged high blood pressure. Read Full Article. ...
Central serous retinopathy, CSR, is a disease in which a serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium (RPE).
Hypertensive retinopathy is related to high blood pressure Hypertensive retinopathy is graded according to seriousness Ophthalmic examination...
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Sickle Cell Retinopathy is recognized by the following codes as per the International Classification of Diseases (ICD) nomenclature:
Quantitative retinal signs were mainly analyzed as continuous variables and qualitative retinal signs were analyzed as binary variables. The association between retinal signs and vascular risk factors was assessed using linear and logistic regression to adjust for age, gender, and race.. In the main analysis, we used linear regression to model each of the DSST score, gait speed, and square root of CES-D score as a function of a retinal sign and covariates, and we used logistic regression to model the probability of depressive mood. Standardized coefficients were computed to compare the strength of associations between retinal signs and each outcome. Depressive symptoms were analyzed in 2 different ways: (1) square root of CES-D score among participants not using antidepressant medications, because CES-D score may not accurately represent the burden of depressive symptoms in these participants; and (2) the presence of depressive mood, as defined, in all participants. Of those with data on all 5 ...
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TY - JOUR. T1 - Assessment of patient-reported outcomes in retinal diseases. T2 - a systematic review. AU - Prem Senthil, Mallika. AU - Khadka, Jyoti. AU - Pesudovs, Konrad. N1 - Copyright © 2017 Elsevier Inc. All rights reserved.. PY - 2017/1/8. Y1 - 2017/1/8. N2 - Advances in the understanding of the genetic, molecular, and cellular biology of retinal diseases have led to the development of new treatments. These expanding treatment options demand appropriate outcome measures for studies of treatment benefit including patient-reported outcomes (PROs). A plethora of PRO instruments assess impacts of retinal diseases from the patients perspectives. We review all the studies that implemented PRO assessment in retinal diseases and also discuss quality assessment of the PRO instruments. We also include qualitative studies that explored quality of life impact on people with retinal diseases. Most studies used PRO instruments not specifically developed for retinal diseases (non-disease specific), ...
Hypertensive retinopathy is a syndrome that commonly affects older cats causing an abrupt onset of bilateral blindness. This condition is often associated with a cat that suddenly begins to bump into things, appears to be lost, and displays very cautious movements. The loss of vision is associated with dilated pupils that are unresponsive or poorly responsive to incoming light. Affected eyes may appear slightly cloudy, and focal red areas may be visible thorough the pupil, as a result of retinal hemorrhage. This condition is often associated with a systemic hypertension, which is another term for high blood pressure. The retina is a thin-layered photo sensory nerve tissue, that is closely adhered to the posterior fibrous coat of the eye. When rays of light enter the eye they are focused onto the retina by the cornea and the lens. The retina then transmits a signal to the optic nerve for the brain to interpret as an image. The retina itself contains blood vessels making it vulnerable to damage ...
Trusted Hypertensive Retinopathy Specialist serving DeSoto, TX & Plano, TX. Visit our website to book an appointment online: Retina Specialists
Hypertensive retinopathy is a complication of high blood pressure (hypertension) affecting the retina. Learn about it here and schedule an eye exam now!
Approach and Results-Pregnant Sprague Dawley rats were fed LS (0.03% NaCl) or normal salt (0.3% NaCl) diets, and ischemic retinopathy was induced in the offspring. An LS diet reduced retinal neovascularization and vaso-obliteration, the mRNA and protein levels of the angiogenic factors, vascular endothelial growth factor, and erythropoietin. Microglia, which influence vascular remodeling in ischemic retinopathy, were reduced by LS as was tumor necrosis factor-α. Macroglial Müller cells maintain the integrity of the blood-retinal barrier, and in ischemic retinopathy, LS reduced their gliosis and also vascular leakage. In retina, LS reduced mineralocorticoid receptor, angiotensin type 1 receptor, and renin mRNA levels, whereas, as expected, plasma levels of aldosterone and renin were increased. The aldosterone/mineralocorticoid receptor-sensitive epithelial sodium channel alpha (ENaCα), which is expressed in Müller cells, was increased in ischemic retinopathy and reduced by LS. In cultured ...
NDP-related retinopathies are X-linked recessive disorders characterized by very early childhood eye diseases/disorders due to degenerative and proliferative changes of the neuroretina. The spectrum of retinal findings ranges from Norrie disease (ND) to X-linked familial exudative vitreoretinopathy (FEVR), including some cases of persistent hyperplastic primary vitreous (PHPV), Coats disease, and advanced retinopathy of prematurity (ROP). These phenotypes appear to be a continuum of retinal findings with considerable overlap. The ocular findings that permit a presumptive diagnosis of an NDP-related retinopathy include the following: Bilateral, often symmetric, involvement of the eyes Normal-sized eyes, with normal anterior chambers and usually clear lenses at birth Vitreous abnormalities (hemorrhage, membranes, detachment, and/or vitreoretinal attachments) Presence of fibrous and vascular retinal changes at birth with progressive changes through childhood or adolescence The most severe phenotype ...
Retinitis Pigmentosa and other inherited retinal diseases can now be diagnosed with advanced electrophysiology, optical imaging, and genetic testing. In addition, innovative thereuputics including gene therapy and cell transplant are now being tested by our faculty.. ...
Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potential role as a neuroprotective agent for retinal diseases has received little attention. In addition, DMFs mode of action remains elusive, although studies have suggested nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an important mechanism. Here we investigated the neuroprotective role of monomethyl fumarate (MMF), the biologically active metabolite of DMF, in retinal ischemia-reperfusion (I/R) injury, and examined the role of Nrf2 in mediating MMF action. Wild-type C57BL/6J and Nrf2 knockout (KO) mice were subjected to 90 min of retinal ischemia followed by reperfusion. Mice received daily intraperitoneal injection of MMF. Inflammatory gene expression was measured using quantitative
OBJECTIVE:. The objective of this study is to investigate whether there is a correlation between genetic mutations, beginning with an analysis of ABCA4, and Plaquenil -induced retinal toxicity and to describe the phenotype of Plaquenil -induced retinal toxicity.. STUDY POPULATION:. The study will enroll 45 patients, 18 years of age or older, found to have Plaquenil -induced retinal toxicity. Seventy-five volunteers with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or Sj(SqrRoot)(Delta)gren s syndrome and history of Plaquenil use, but without evidence of retinal toxicity, will also be recruited.. DESIGN:. The study is an observational study with 1-2 outpatient visits to the NEI clinic or review of medical records for off-site participants. All participants will provide a blood sample for genetic analysis.. OUTCOME MEASURES:. Clinical examination and blood samples will be used for genetic testing and mutation identification. The outcome of this study is to identify genetic ...
In the evaluation of retinal findings, the development and progression of retinopathy were defined as a change of 2 steps up or more in a modified ETDRS scale of 19 stages in the Kumamoto Study, 3 steps up or more in a ETDRS scale of 25 stages in the DCCT, and 2 steps up in a modified ETDRS scale of 21 stages in the UKPDS (2,6,9 11,16). Because the patients with preproliferative retinopathy at the initiation of the study were not included in the Kumamoto Study, this classification system of 19 stages allowed us to evaluate the retinal findings efficiently. The cumulative percentage of patients showing the worsening in retinal findings was significantly less in patients receiving intensive insulin treatment than in those receiving conventional insulin treatment. With intensive insulin therapy, the risks of retinopathy were reduced in the primary prevention, the secondary intervention, and the combined cohorts. The risk calculated by proportional-hazards analysis in the combined cohort was ...
Purtschers retinopathy characterized by the appearance of cotton-wool spots and intraretinal hemorrhage at the posterior pole that commonly occurs after severe head and chest trauma. We report a pati...
The study shows that people with type 2 diabetes without retinopathy at the time of their first retinal examination were at low risk of progressing to preproliferative retinopathy (requiring referral to an ophthalmologist) and at very low risk of progressing to either PDR or maculopathy (requiring treatment) even after 5 years of follow-up. In contrast, patients with nonproliferative or preproliferative retinopathy at their first retinal examination were at much higher risk of progression. These findings support increasing the screening intervals in people with diabetes and without retinopathy detected at earlier screening examinations and are in keeping with our previous analysis of retinopathy prevalence at screening (5) and with other longitudinal studies of retinopathy incidence and progression (6,10-13). In this program, 80% of patients had no retinopathy at their first examination, so screening them less frequently could substantially reduce costs, allow limited resources to be shifted to ...
The retina is the light-sensitive layer of tissue at the back of the inner eye. It acts like the film in a camera - images come through the eyes lens and are focused on the retina. The retina converts these images to electrical signals and sends them via the optic nerve to the brain, allowing us to see. Retinal diseases disrupt your retinas ability to do its job, affecting your vision.. Mount Sinai offers expertise in the diagnosis and treatment of retinal disease. Our researchers and clinicians have been engaged in the field of eye care and research since the mid-1880s. More than 18,000 people seek eye care at Mount Sinai each year. Our eye care professionals are dedicated to providing you with the finest treatment available today.. Our retinal disease specialists include:. Scott E. Brodie, MD, PhD ...
While our programs focus is on training outstanding vitreoretinal surgeons, a strong medical retina and uveitis clinic supports our fellows training on the medical aspects of retinal diseases. The fellow has extensive exposure to the medical management of common retinal diseases as well as some of the most challenging medical retina conditions a retina physician may face. Clinical training encompasses retinal degenerative diseases with numerous opportunities for intravitreal injections, inherited retinal diseases, in-office care of peripheral retinal pathologies including pneumatic retinopexy and laser retinopexy using both slit-lamp laser delivery system and indirect ophthalmoscopy lasers. Our clinic is equipped with photodynamic therapy (PDT) laser for the patients who need this treatment modality and our fellow has the opportunity to participate in it. We are proud of having state of the art retina imaging facility and fellows will learn to interpret imaging data from a variety of modalities ...
Gazing at a the sun can cause a small macular burn with central vision loss. Learn more at Bennett & Bloom Eye Centers serving Louisville and more.
Diabetic retinopathy is best diagnosed with a dilated eye exam. A yearly eye exam at our Calgary eye clinic can help prevent diabetic vision loss.
a)Health benefits policies may not require that an optometrist hold hospital staff privileges.. (b)When any health benefits policy provides for the payment of eye care benefits or vision care benefits, such policy shall be construed to include payment to all eye care providers who provide benefits within the scope of their providers licenses.. (c)Any limitation or condition placed upon services, diagnosis or treatment by or payment to a particular type of licensed provider shall apply equally to all licensed providers without unfair discrimination as to the usual and customary treatment procedures of an eye care provider.. (d)Any health benefits policy that includes eye care benefits, including a diabetic retinal examination, shall provide each covered person diagnosed with diabetes direct access to an eye care provider of their choice from the insurers panel of providers independent of, and without referral from, any other provider or entity for one annual diabetic retinal examination. The ...
Figure caption and citation for the preceding image starts]: Nonproliferative diabetic retinopathy: exudate (yellow arrow), microaneurysms (red arrow), cotton wool spot (white arrow), nerve fiber layer hemorrhage (green arrow) Courtesy of Moorfields Photographic Archive; used with permission [Citation ends]. Blood vessels in the eye may leak fluid into the retina, which leads to blurred vision. Proliferative diabetic retinopathy (PDR) is the more advanced form of the disease. New blood vessels start to grow in the eye (neovascularization), which are fragile and can hemorrhage. ...
We have not found evidence that deletions within the D4Z4 repeat array are associated with abnormal regulation of gene expression on chromosome 4q35. Only a single gene within 8 Mb of the D4Z4 repeat, LRP2BP, showed abnormal expression that was specific to FSHD. However, neither this gene nor FRG1 itself showed imbalance of allelic expression. Although we did observe a weak correlation between size of the residual D4Z4 array and expression level for FRG1, we did not observe upregulation of FRG1 mRNA in FSHD, assessed either by microarray analysis or qRT-PCR. In the context of recent transgenic mouse models, in which 20-fold or greater overexpression of FRG1 was required to induce skeletal myopathy,14 it is noteworthy that none of the FSHD muscle samples in the current study showed ,1.5-fold upregulation of FRG1 by microarray analysis. We also considered models involving longer range effects of the FSHD deletion on 4q gene expression, either through mislocalization of the mutant chromosome in the ...
دليل المعلومات الطبي يحتوي على مكتبة طبية, موسوعات, منتديات, والمزيد من المعلومات الطبية المفيدة لكل الطلاب والدارسين في المجال الطبي.
To study the relationship between cone spacing and density and clinical measures of visual function near the fovea. High-resolution images of the photoreceptor mosaic are obtained with Adaptive Optics Scanning Laser Ophthalmoscopy. ...
Retinal diseases can severely affect the sight and health of the eye. Our retinal surgeons, Dr. Ko and Dr. Glazer-Hockstein at our Wilmington office focus on retinal diseases detachment, tears, and vascular disease and provide treatments that restore health and sight to the patient.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
LUXTURNA is the first pharmacologic treatment indicated for inherited retinal disease and the first adeno-associated virus vector gene therapy approved in the USA.
Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. 572. pp. 29-33. doi:10.1007/0-387-32442-9_5. ISBN ... "Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition". Scientific Reports. 5 ... "Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in ...
"Inflammatory Retinal Diseases. Medical information , Patient". Patient. Retrieved 2016-03-16. V, Narendran; Kothari, Abhishek ( ... List of systemic diseases with ocular manifestations Progressive outer retinal necrosis "Cytomegalovirus retinitis : ... Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil ... Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be ...
"Inflammatory Retinal Diseases. Medical information". patient.info. Retrieved 2020-04-25. "Cytomegalovirus Adult and Adolescent ... This corticosteroid is usually used to treat disorders and diseases including macular edema secondary to retinal vein occlusion ... "Intravitreal Steroids for the Treatment of Retinal Diseases". The Scientific World Journal. 2014: 1-15. doi:10.1155/2014/989501 ... in turn curing various eye diseases. Disorders/diseases that can be treated with intravitreal injection include: Age-related ...
"Acucela - Retinal Diseases". acucela.com. Retrieved 2016-03-01. Protein Structure and Function Båvik CO, Busch C, Eriksson U ( ... The photoisomerization of 11-cis-retinal to all-trans-retinal initiates the phototransduction pathway through which the brain ... multiplex PCR and mutation screening in patients from India with retinal degenerative diseases". Journal of Genetics. 81 (1): ... "Entrez Gene: RPE65 retinal pigment epithelium-specific protein 65kDa". Wolf G (Mar 2005). "Function of the protein RPE65 in the ...
Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology. 801. pp. 291-300. doi:10.1007/978-1-4614-3209-8_ ... single-disease hypothesis holds for Mendelian disorders such as Huntington's disease and cystic fibrosis, complex diseases and ... Celiac disease (CD) is a complex immune disorder that has been found to have strong genetic links in disease. In particular, ... In the table below is a performance comparison of diseases selected on disease frequency and known heritability estimates, with ...
"Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69. doi:10.1016/j.preteyeres.2017.01. ... over 100 disease-causing mutations have been related to BVMD as well as a number of other degenerative retinal diseases. Adult- ... Retinal Degenerative Diseases. review. Advances in Experimental Medicine and Biology. 723. pp. 603-10. doi:10.1007/978-1-4614- ... Mutations in the BEST1 gene have been identified as the primary cause for at least five different degenerative retinal diseases ...
Bedford, Peter (2006). "Hereditary Retinal Diseases" (PDF). Proceedings of the 31st World Congress of the World Small Animal ... CEA can also cause retinal or scleral coloboma, coloboma of the optic disc, retinal detachment, or intraocular hemorrhage. It ... It can be a mild disease or cause blindness. CEA is caused by a simple autosomal recessive gene defect. There is no treatment. ... Lowe J, Kukekova A, Kirkness E, Langlois M, Aguirre G, Acland G, Ostrander E (2003). "Linkage mapping of the primary disease ...
"Retinal diseases - Symptoms and causes". Mayo Clinic. "Understanding how immune cells cause scarring in wet age-related macular ... Macular scarring is formation of the fibrous tissue in place of the normal retinal tissue on the macular area of the retina ...
Diabetic Eye Disease John F., Salmon (2020). "Retinal vascular disease". Kanski's clinical ophthalmology : a systematic ... Although often brief and harmless, they may be a sign of retinal detachment. Retinal detachment: Symptoms include floaters, ... A retinal migraine is when you have only visual symptoms without a headache. Reduced blinking: Lid closure that occurs too ... "WHO , Priority eye diseases". WHO. Retrieved 2020-09-02. Coursey, Terry G; de Paiva, Cintia S (2014-08-04). "Managing Sjögren's ...
Retinal Vascular Disease. Springer. pp. 430-. ISBN 978-3-540-29541-9. Retrieved 29 June 2010. CS1 maint: discouraged parameter ... and only a small proportion will proceed to develop this disease (which causes joint pains, skin problems and kidney failure, ...
Retinal diseases at TU Teaching Hospital. J.K. Shrestha, S. Koirala, OK Malla, S. Miller. Journal of the 1997, 19:13-17. 11. ... 2. Von 's disease (Neurofibromatosis): Case report: P.C. Karmacharya, S. Koirala, M.P. Upadhyay J. Inst. Med. P. 113 3. ... 1992; 30:120-124). 7. Knowledge Attitude and Practice (KAP) Towards Eye disease: Finding of a Survey in Rural Bhaktapur. ...
February 2007). "Genotype-phenotype correlation in von Hippel-Lindau disease with retinal angiomatosis". Archives of ... Around 1 in 8000 people will have this disease and it has approximately 100% penetrance. An individual with this disease will ... The reason for the large clinical spectrum of this disorder may be due to other gene mutations that modify the disease. The ... The disease is characterized by basal cell nevi, jaw keratocysts and skeletal abnormalities. Estimates of NBCCS prevalence ...
Bakall B, Hariprasad SM, Klein KA (July 2018). "Emerging Gene Therapy Treatments for Inherited Retinal Diseases". Ophthalmic ... Ameri H (March 2018). "Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal ... or biallelic RPE65-mediated inherited retinal disease, is an inherited disorder causing progressive blindness. Voretigene is ... Voretigene neparvovec is indicated for the treatment of people with vision loss due to inherited retinal dystrophy caused by ...
"RetNet: Genes and Mapped Loci Causing Retinal Diseases". RetNet. Retrieved 12 May 2015. Han J, Dinculescu A, Dai X, Du W, Smith ... Similar to rd1 in mice, Rod-cone dysplasia type 1 (rcd1-PRA) is a form of progressive retinal atrophy (PRA), with early onset ... Anant JS, Ong OC, Xie HY, Clarke S, O'Brien PJ, Fung BK (Jan 1992). "In vivo differential prenylation of retinal cyclic GMP ... PDE6 is a highly concentrated protein in retinal photoreceptors. With the presence of the GAF domain, PDE6 can actively bind to ...
Minireview: Fibronectin in retinal disease. Exp Biol Med (Maywood). 2017 ;242(1):1-7 Goyal R, Vega ME, Pastino AK, Singh S, ...
Structural implications for retinal disease". FEBS Letters. 528 (1-3): 17-22. doi:10.1016/S0014-5793(02)03241-6. PMID 12297272 ... Retinal is produced in the retina from vitamin A, from dietary beta-carotene. Isomerization of 11-cis-retinal into all-trans- ... A second product of Meta II decay is an all-trans-retinal opsin complex in which the all-trans-retinal has been translocated to ... This means replacing all-trans-retinal with 11-cis-retinal and the decay of Meta II is crucial in this process. During the ...
Structural implications for retinal disease. Volume 528, Issues 1-3, 25 September 2002, Pages 17-22. V.R. Rao, G.B. Cohen and D ... Audo I, Robson AG, Holder GE, Moore AT (2008). "The negative ERG: clinical phenotypes and disease mechanisms of inner retinal ... Nakamura M, Ito S, Piao C, Terasaki H, Miyake Y (2003). "Retinal and optic disc atrophy associated with a CACNA1F mutation in a ... The third mutation is Ala292Glu, and it is located in the seventh transmembrane helix, in proximity to the site of retinal ...
Her research focuses on gene therapy for retinal diseases. Her laboratory developed the first FDA approved gene therapy for use ... Currently, her laboratory is investigating gene therapy approaches for other retinal diseases. Sanford Lorraine Cross Award, ... "Vision test for determining retinal disease progression", issued 2015-11-04 [21], "Compositions and methods for self-regulated ... Vision test for determining retinal disease progression (Application PCT/US2015/058958) Compositions and methods for self- ...
Bhattacharya, Sanjoy (May 2009). "Retinal deimination in aging and disease". IUBMB Life. 61 (5): 504-509. doi:10.1002/iub.184. ... Citrullinated vimentin may be an autoantigen in RA and other autoimmune diseases, and is used to study RA. Moreover, antibodies ... In adults, MBP deimination is found in demyelination diseases such as multiple sclerosis. MBP may affect different cell types ... In the normal retina, deimination is found in nearly all the retinal layers, including the photoreceptors. Deimination has been ...
"Retinal astrocytic hamartoma and Bourneville's disease". Oman J Ophthalmol. 5 (3): 198-9. doi:10.4103/0974-620X.106108. PMC ... Retinoblastoma protein Coats' disease Trilateral retinoblastoma Pinealoblastoma India portal Medicine portal Long link - please ... "Rosai dorfman disease of the orbit". J Hematol Oncol. 1: 7. doi:10.1186/1756-8722-1-7. PMC 2474646. PMID 18588698.CS1 maint: ... "Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1". J AAPOS. 13 (1): 97-8. doi:10.1016/j.jaapos. ...
Structural implications for retinal disease.". FEBS Lett. 528 (1-3): 17-22. PMID 12297272. doi:10.1016/S0014-5793(02)03241-6.. ... Isto significa que hai que substituír o todo-trans-retinal por 11-cis-retinal e a descomposición de metarrodopsina II (Meta II ... Prodúcese unha isomerización da configuración 11-cis-retinal a todo-trans-retinal causada pola luz, que induce un cambio ... trans-retinal / opsina, no cal o todo-trans-retinal foi translocado a outros sitios de unión. Que a descomposición do Meta II ...
Structural implications for retinal disease.". FEBS Lett. 528 (1-3): 17-22. PMID 12297272. doi:10.1016/S0014-5793(02)03241-6.. ... Retinal nastaje u retini iz Vitamina A, dijetarnog beta-karotena. Izomerizacija 11-cis-retinala u sve-trans-retinal pod ... GDP molekul je vezan u Gtα-podjedinici i kovalento vezani retinal (crno ) je u rodopsinu. N-terminus rodopsina je crven i C- ... Retinal zauzima horizontalan položaj u odnosu na membranu. Svaki spoljašnji segment diska sadrži hiljade vizuelnih molekula ...
Numerous neuronal and retinal diseases have LPO in their etiology. To put things in perspective, the brain makes up 1.5-2% of ... Parkinson's disease (MPTP and a-Syn models in mice and rats) Huntington's disease (in mice) Alzheimer's disease (APP/PS1 and ... However, in certain disease states, the natural PUFA maintenance system is not able to cope with disease-related increased ... Any process that either increases oxidation of PUFAs or hinders their ability to be replaced can lead to serious disease. ...
The eye care professional will look at the retina for early signs of the disease, such as: leaking blood vessels, retinal ... Seah, Ivan (January 30, 2020). "Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases". Eye. 34: ... Gupta A, Cavallerano J, Sun JK, Silva PS (17 October 2016). "Evidence for Telemedicine for Diabetic Retinal Disease". Seminars ... Diabetic diet Purtscher's retinopathy, a disease with similar abnormalities in the eye, usually caused by trauma. Retinal ...
Song D, Dunaief JL (2013). "Retinal iron homeostasis in health and disease". Frontiers in Aging Neuroscience. 5: 24. doi: ... copper storage disease). Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency ... O'Brien PJ, Bruce WR (2009). Endogenous Toxins: Targets for Disease Treatment and Prevention, 2 Volume Set. John Wiley & Sons. ... Like any other plasma protein, levels drop in patients with hepatic disease due to reduced synthesizing capabilities. ...
By analogy to Coats disease, the exudative retinopathy is thought to result from breakdown of the blood-retinal barrier at the ... doctor/1926 at Who Named It? Coats G (Nov 1908). "Forms of retinal disease with massive exudation". R Lond Ophthalmol Hosp Rep ... These findings mimic Coats disease. Characteristically, the abnormal vessels are localized and the retinal blood vessels ... In some eyes, retinal vessels form small nodules on the surface of the retina, known as angiomas. These can bleed and be ...
The Retinal Pigment Epithelium: Function and Disease. Gallemore RP, Hughes BA and Miller SS (1998) "Light-induced responses of ... The Retinal Pigment Epithelium: Function and Disease". Gallemore RP, McCuen B II. (2000) "Silicone oil tamponade in ... "Diagnosis of vitreoretinal adhesions in macular disease with optical coherence tomography." Retina-the journal of retinal and ... Hughes, BA, Gallemore, RP and Miller, SS (1998) "Transport mechanisms in the retinal pigment epithelium". In: The retinal ...
Retinal diseases in dogs include retinal dysplasia, progressive retinal atrophy, and sudden acquired retinal degeneration. ... This strategy is effective against a number of retinal diseases that have been studied, including neovascular diseases that are ... When light strikes 11-cis-retinal (in the disks in the rods and cones), 11-cis-retinal changes to all-trans-retinal which then ... Modification of systemic risk factors for retinal disease. Uncommon treatment modalities[edit]. Rare or uncommon methods of ...
SCGH has the Australian Inherited Retinal Disease Registry and DNA Bank (AIRDR) on-site. AIRDR analyses the DNA of consenting ... De Roach, J., Chelva, E., Laurin, S., Lamey, T & Price, R.I. (2007). The western Australian inherited retinal disease dna ... The AIRDR resource is available to researchers pursuing an interest in the varying causes of inherited retinal disease. The ... "Australian Inherited Retinal Disease Registry and DNA Bank". Department of Health, Western Australia. 15 September 2020. ...
... retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, ... and progression of these endemic diseases. In Animal Models for Retinal Diseases, recognized experts in the field highlight ... the book continues by covering animal models for the research of specific human retinal diseases, e.g., retinal degeneration, ... Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular ...
Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), held July 13-18, 2014 at the ... Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease ... My Retina Tracker™: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases ... The Symposium addressed the blinding diseases of inherited retinal degenerations, which have no effective treatments, and age- ...
Mayo Clinic has a long history of research on retinal diseases and cancers of the eye. The large number of people who seek care ... See a list of publications by Mayo Clinic doctors on retinal diseases on PubMed, a service of the National Library of Medicine. ... Mayo Clinic eye experts combine patient care with research to expand the understanding of retinal conditions. ... Retinal surgery, Diabetic retinopathy, Retinal detachment, Retinal disease more see full list in profile ...
Mayo Clinic has a long history of research on retinal diseases and cancers of the eye. The large number of people who seek care ... See a list of publications on retinal diseases by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. ... Mayo Clinic eye experts combine patient care with research to expand the understanding of retinal conditions. ...
Inherited retinal diseases-or IRDs-are a group of diseases that can cause severe vision loss or even blindness. Each IRD is ... What are Inherited Retinal Diseases (IRDs)?. Inherited retinal diseases-or IRDs-are a group of diseases that can cause severe ... Stargardt Disease. Stargardt Disease. Stargardt disease is also called Stargardt macular dystrophy. The disease causes damage ... What Increases the Risk for Inherited Retinal Diseases?. IRDs are diseases that result from variants in our DNA. DNA is the ...
Electrodiagnosis of Retinal Disease. Authors. * Yozo Miyake Copyright. 2006. Publisher. Springer Japan. Copyright Holder. ... It provides rapid and easily accessible descriptions of the major retinal diseases and specifies the information needed for ... As such,this book does not include every clinical disease but only those that we have identi?ed or studied in detail. In ... "In this book Yozo Miyake succeeds … in presenting a broad range of possible applications of retinal electrodiagnostics. … This ...
... very prestigious conference A comprehensive source for the latest basic research in the field of retinal degenerative diseases ... Retinal Degenerative Diseases. Mechanisms and Experimental Therapy. Editors: Ash, J., Grimm, C., Hollyfield, J.G., Anderson, R. ... Retinal Degenerative Diseases. Book Subtitle. Mechanisms and Experimental Therapy. Editors. * John Ash ... The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures ...
Behcets disease with retinal vascular lesions. Br Med J 1967; 2 :220 ... Behcets disease with retinal vascular lesions.. Br Med J 1967; 2 doi: https://doi.org/10.1136/bmj.2.5546.220 (Published 22 ...
... a platform that uses big data and artificial intelligence not only to recognize two of the most common retinal diseases but ... He explains that diagnosing and treating retinal diseases normally involves visiting a general medical doctor or an optometrist ... they describe a platform that uses big data and AI not only to recognize two of the most common retinal diseases but also to ... Earlier studies have used machine learning to study retinal images, but the authors of the new study say their platform goes a ...
What is very rewarding for me is that FFBs support helped us find the retinal-disease gene mutation in 33 families, who were ... 9:00 a.m. PDT - 10:15 a.m. PDT- Opening Session: Mission Possible! The Years Top Advances and Whats Next in Retinal Disease ... In fact, inherited retinal diseases are caused by mutations in single genes.. Continue Reading… ... Get the inside scoop on this years top research advances and whats next in retinal disease science by watching VISIONS 2018 ...
... physiology and diseases of the eye. Submissions should focus on focusing on new diagnostic and surgical techniques, instrument ... In Vivo Molecular Imaging in Retinal Disease. Fang Xie,1 Wenting Luo,2 Zhongyu Zhang,2 and Dawei Sun2 ... Yannis M. Paulus, and Akrit Sodhi, "Anti-angiogenic Therapy for Retinal Disease," 2016. View at Publisher · View at Google ... α activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles," ...
This review will cover recent findings on retinal degeneration in AD, pathological similarities between AD and eye diseases, ... Alzheimers disease (AD) is the major cause of dementia in the world. Although the entorhinal cortex and hippocampal complex ... Keywords: Age-related macular degeneration; Alzheimers disease; Aß deposition; DARC; Glaucoma; Real time imaging technology; ... the retina has been recently shown to be effective in the reduction of retinal neuronal degeneration and loss in eye diseases. ...
Inherited Retinal Diseases and Degenerations/Retinitis Pigmentosa. Retinitis Pigmentosa and other inherited retinal diseases ... Vitreoretinal & Macular Diseases. *Macular Degeneration*Diabetic Retinopathy*Macular Surgery*Retinal Detachment*Pediatric ... Rare eye disease is focus of new Stanford Medicine center*DIYs at risk for increase in eye injuries during Coronavirus (COVID- ... Cornea & External Disease*Glaucoma*Neuro-Ophthalmology. Neuro-Ophthalmology. *Applications*Fellows. *Ophthalmic Plastic & ...
... or branch retinal arteries. The common presenting symptom is a sudden, painless loss of vision ... Retinal artery occlusions may involve the ophthalmic, central, ... Retinal Vascular Diseases: Retinal Artery Occlusions. George J ... Retinal artery occlusions may involve the ophthalmic, central, or branch retinal arteries. The common presenting symptom is a ... Retinal Vascular Diseases: Cystoid Macular Edema and Related Diseases Course Peripheral Retinal Lesions in Profile Course ...
Part XII: Investigations of Human Retinal Disease *Retinal Degeneration, Remodeling and Plasticity by Bryan William Jones, ... Seminar: Cellular Response Associated to Retinal Diseases and Therapeutic Approaches. Nicolás Cuenca, professor Department of ... New Webvision Chapter: Retinal Degeneration, Remodeling and Plasticity. We have a new Webvision chapter on Retinal Degeneration ... Abstract: At the cellular and molecular level, the response to retinal injury is similar in diseases like AMD, glaucoma, ...
Diseases : Retinal Degeneration: Light-Induced, Retinal Diseases. Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory ... Diseases : Eye Damage, Oxidative Stress, Retinal Diseases, Ultraviolet Radiation Induced Damage. Pharmacological Actions : ... Diseases : Diabetic Retinopathy, Glaucoma, Inflammation, Macular Degeneration, Retinal Diseases. Pharmacological Actions : Anti ... Diseases : Inflammation, Retinal Diseases. Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP- ...
There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, ... Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked ... In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was ... Category: Opthalmology Tags: Disease of the Year: Cerebrovascular Disorders Source Type: research ...
No one in the retinal disease research community brought more passion and commitment to his or her work than Dr. Eliot Berson. ... 9:00 a.m. PDT - 10:15 a.m. PDT- Opening Session: Mission Possible! The Years Top Advances and Whats Next in Retinal Disease ... Get the inside scoop on this years top research advances and whats next in retinal disease science by watching VISIONS 2018 ... As most people affected by retinal diseases know, firsthand, there are relatively few eye doctors who understand and can ...
The therapeutic potential of CoQ10 for other retinal diseases was also discussed. Results: CoQ10 has been applied in different ... Conclusion: A wide range of evidence supports a role of CoQ10 in retinal diseases through inhibiting production of reactive ... "Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases".. More about this publication? *. Current Medicinal Chemistry ... Oxidative stress is a major contributory factor in the process of retinal degeneration. Method: The related literature was ...
Injectable Liquid Prosthesis to Treat Retinal Diseases Developed. June 29th, 2020 Medgadget Editors Materials, Ophthalmology ... Rapid Diagnosis of Infectious Disease at Point of Care: Interview with Shawn Marcell, CEO of Torus Biosystems. Mobility-Enabled ... Retinal prostheses promise the restoration of vision to people with age-related macular degeneration, retinitis pigmentosa, and ... A number of technologies are already in existence that mimic the functionality of the retina by stimulating the inner retinal ...
... an eminent professor at University of Oxford pioneering gene treatments for retinal disease. ... Gene therapy for retinal disease is the next class of medicines to become available to patients. Professor MacLaren is a leader ... New gene therapy treatments for retinal diseases. Professor Robert MacLaren, Professor of Ophthalmology, University of Oxford ... Lang lecture: New gene therapy treatments for retinal diseases. This event has now passed ...
This is a peripheral retinal change most frequent in patients with hemoglobin SC but also can be present in patients wit... ... How are proliferative retinal changes characterized in sickle cell disease (SCD)?. Updated: Sep 30, 2020 ... Risk factors for conjunctival and retinal vessel alterations in sickle cell disease. Acta Ophthalmol Scand. 2006 Apr. 84(2):234 ... Drugs & Diseases , Ophthalmology , Ophthalmologic Manifestations of Sickle Cell Disease (SCD) Q&A ...
... Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. ... "Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease," International Journal of Inflammation, vol. 2013, ...
Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human ... Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone ... advanced retinal imaging, and electrophysiology consistent with achromatopsia. Genetic sequencing confirmed a homozygous R565Q ...
... a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. ... Novel Pathway Regulates Angiogenesis - May Fight Retinal Disease, Cancer. Sunday, May 29, 2011 ... This presents a number of new research opportunities to test its influence on retinal diseases that are often associated with ... Branching Retinal Blood Vessels. The top images show (at left) deep layer branching blood vessel formation in the retina of a ...
The Spanish firm Sylentis has developed a compound to treat diseases of the retina, such as age-related macular degeneration ... A-drug-to-treat-retinal-diseases-with-drops-instead-of-injections More in Medicine & Health. * Stable ischemic heart disease in ... A drug to treat retinal diseases with drops instead of injections. FECYT - Spanish Foundation for Science and Technology ... A Drug to Treat Retinal Diseases with Drops Instead of Injections (IMAGE) view more ...
The Spanish firm Sylentis has developed a compound to treat diseases of the retina, such as age-related macular degeneration ... Retinal diseases could be treated by ophthalmic drops instead of intraocular injections. *Download PDF Copy ... www.agenciasinc.es/en/News/A-drug-to-treat-retinal-diseases-with-drops-instead-of-injections ... The Spanish firm Sylentis has developed a compound to treat diseases of the retina, such as age-related macular degeneration ...
The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal ... Part XII: Investigations of Human Retinal Disease *Retinal Degeneration, Remodeling and Plasticity by Bryan William Jones, ... Part VI: Retinal Neurogenesis: Early stages in the development of neurons and pathways *Formation of Early Retinal Circuits in ... Dynamics of retinal degeneration in the rd10 mouse was also examined including an analysis of retinal vasculature and kinetics ...
Retinal bleeding has an occurrence rate of seven cases per 1,000 people, making it one of the most common causes of decreased ... There are three types of retinal hemorrhage. Abnormal blood vessel hemorrhage is the result of damage from diseases such as ... There are several behaviors and diseases that increase a persons chance of suffering from retinal hemorrhage. In addition to ... What Is the Standard Treatment for Retinal Edema?. A: The standard treatment for retinal edema is topically applied NSAIDs, ...
  • This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). (springer.com)
  • The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. (springer.com)
  • These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. (springer.com)
  • It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. (springer.com)
  • Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2010 meeting and included in the proposed volume. (springer.com)
  • To create a forum for scientists and clinicians interested in degenerative retinal diseases, we began in 1984 to organize a biennial symposium on Retinal Degeneration as a satellite meeting of the International Congress of Eye Research. (springer.com)
  • The VIII International Symposium on Retinal Degeneration was held from July 28-25, 1998, at the Hotel Vier Jahreszeiten in Schluchsee, a small town in the Black Forest of southwestern Germany. (springer.com)
  • A variety of diagnostic, clinical, histopathological, and physiological assessments of retinal degeneration in patients are also included. (springer.com)
  • The AD-related changes in the retina are associated with degeneration and loss of neurons, reduction of the retinal nerve fibres, increase in optic disc cupping, retinal vascular tortusity and thinning, and visual functional impairment. (ingentaconnect.com)
  • Targeting AD-liked changes in the retina has been recently shown to be effective in the reduction of retinal neuronal degeneration and loss in eye diseases. (ingentaconnect.com)
  • This review will cover recent findings on retinal degeneration in AD, pathological similarities between AD and eye diseases, and highlight the potential of modern technologies for the detection of prospective biomarkers in the eye in early AD. (ingentaconnect.com)
  • A diet supplemented with grapes rescued retinal structure and function in an oxidative stress-induced mouse model of retinal degeneration. (greenmedinfo.com)
  • An Acer palmatum extract prevents N-ethyl-N-nitrosourea-induced retinal degeneration. (greenmedinfo.com)
  • Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. (greenmedinfo.com)
  • MCs demonstrate changes in metabolism and morphology during retinal degeneration . (utah.edu)
  • Oxidative stress is a major contributory factor in the process of retinal degeneration. (ingentaconnect.com)
  • Method: The related literature was reviewed through searching PubMed using keywords: CoQ10, CoQ10 and oxidative stress, CoQ10 and retinal degeneration. (ingentaconnect.com)
  • Retinal prostheses promise the restoration of vision to people with age-related macular degeneration, retinitis pigmentosa, and other conditions that lead to the loss of functional photoreceptors. (medgadget.com)
  • The Spanish firm Sylentis has developed a compound to treat diseases of the retina, such as age-related macular degeneration and diabetic retinopathy, which will be administered by ophthalmic drops instead of intraocular injections. (eurekalert.org)
  • Hereditary diseases such as aceruloplasminemia, Friedreich's ataxia, pantothenate kinase-associated neurodegeneration, and posterior column ataxia with retinitis pigmentosa involve retinal degeneration associated with iron dysregulation. (mdpi.com)
  • In addition to hereditary causes, dietary or parenteral iron supplementation has been recently reported to elevate iron levels in the retinal pigment epithelium (RPE) and promote retinal degeneration. (mdpi.com)
  • The scientists, led by Gleeson and UCSD graduate student Carrie M. Louie, discovered that loss of the AHI1 gene, which had already been found to cause Joubert Syndrome, a ciliopathy of mental retardation and impaired balance, also caused severe early onset retinal degeneration in the mouse model that they created. (ucsd.edu)
  • This finding sheds light on one of the potential causes of retinal degeneration, protein mis-trafficking, which has been of fundamental interest in the study of inherited blindness, according to Gleeson. (ucsd.edu)
  • Bilberry anthocyanin extract exhibited protective effects against visible light-induced retinal degeneration. (greenmedinfo.com)
  • Notably, these features were not disease-specific, suggesting that they might correspond to common mechanisms of degeneration or repair in pathologic states. (nih.gov)
  • RPE disease generally paralleled photoreceptor degeneration. (nih.gov)
  • Inherited diseases that lead to retinal degeneration and blindness affect both dogs and people. (petmd.com)
  • I have an interest in diseases of the retina such as those caused by diabetes, and other blood vessel problems such as retinal vein occlusions as well as age related macular degeneration. (spirehealthcare.com)
  • I specialise in the management of Age-related Macular Degeneration, Diabetic Eye disease and Retinal Vein Occlusions. (spirehealthcare.com)
  • Because many retinal diseases such as diabetic retinopathy, retinal vein occlusions, age-related macular degeneration, involve a key inflammatory component, NGIRDS has focused on the study of the resident immune cell in the retina, the microglial cell, and how it interacts with other retinal cells in the healthy and diseased retina. (nih.gov)
  • Retinal findings of the patients with SSc consisted of hard exudates, vascular tortuosity, microhaemorrhage, and macular degeneration. (bmj.com)
  • Dr. Schwartz' primary areas of research include early diagnosis and treatment of diseases such as retinopathy of prematurity (ROP), diabetic eye disease, and macular degeneration. (thesciencenetwork.org)
  • This year, Dr. Schwartz led two new clinical trials testing the use of stem cell-derived retinal pigment epithelial cells to address vision loss in people suffering from Stargardt's macular dystrophy and dry age-related macular degeneration. (thesciencenetwork.org)
  • Sight restoration after retinal degeneration still represents an unmet goal. (epfl.ch)
  • This area is damaged in more common retinal conditions such as macular degeneration and can be damaged by diabetes. (rpbusa.org)
  • The technology was developed in part in collaboration with BioTime scientists and includes composition and methodologies to develop 3-D retinal tissue constructs from pluripotent stem cells for their implantation in patients with advanced stages of retinal degeneration. (businesswire.com)
  • This could lead to vision restoration treatments for a variety of blinding retinal degenerative diseases, particularly retinitis pigmentosa, macular degeneration, and diabetic retinopathy, among other diseases and conditions," said Michael D. West, PhD, Co-Chief Executive Officer of BioTime. (businesswire.com)
  • In MSA, retinal degeneration was closely associated with disease severity and progressively worsened overtime in a predictable fashion, sufficient for biostatistical modeling. (clinicaltrials.gov)
  • His research interests include ocular manifestations of systemic diseases, novel therapeutic agents and new drug delivery systems in the treatment of ocular inflammatory disease, retinal vascular disease, and the pharmacotherapy of age-related macular degeneration. (utah.edu)
  • Using a protein, grown in the laboratory and implanted behind the retina, this promising new procedure offers hope for patients with age-related macular degeneration (AMD) and other retinal diseases. (uconn.edu)
  • LambdaVision's implant can restore high-quality vision to those patients who are no longer candidates for traditional treatments and have end-stage retinal degeneration, Wagner said. (uconn.edu)
  • It is used to treat various eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and infections inside the eye such as endophthalmitis. (wikipedia.org)
  • This manuscript looks at a mechanism of retinal pigment epithelium (RPE) cell death with notable findings identifying therapeutic targets for disorders that involve the RPE cells. (utah.edu)
  • In human induced pluripotent cells, we show that the mutation affects retinal neurogenesis and maturation of retinal pigment epithelium (RPE). (nature.com)
  • Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice. (greenmedinfo.com)
  • A series of enzymatic reactions, located in both the photoreceptor outer segment and the retinal pigment epithelium, transform retinol into the visual chromophore 11- cis -retinal, regenerating visual pigments. (mdpi.com)
  • Among these important proteins are Lecithin:retinol acyltransferase (LRAT) and retinal pigment epithelium-specific 65-kDa protein (RPE65) known to be responsible for esterification of retinol to all- trans -retinyl esters and isomerization of these esters to 11- cis -retinal, respectively. (mdpi.com)
  • We used an algorithm based on computational and experimental data to provide parameters that can cause photothermal stimulation to the retinal pigment epithelium without causing collateral damage to photoreceptors or choroid. (clinicaltrials.gov)
  • 10% and signal strength of ≥ 5 OCT ILM and borders (internal limiting membrane) and RPE (retinal pigment epithelium) properly identified. (clinicaltrials.gov)
  • After spectral domain optical coherence tomography, the macular cube was exported into a novel analysis tool and volumetric assessment from the ellipsoid zone to the retinal pigment epithelium was performed. (ovid.com)
  • Using this information, mapping was completed with en face representation of the height between the ellipsoid zone and retinal pigment epithelium. (ovid.com)
  • Retinitis Pigmentosa and other inherited retinal diseases can now be diagnosed with advanced electrophysiology, optical imaging, and genetic testing. (stanford.edu)
  • Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in 10,000 individuals, respectively. (jci.org)
  • Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness. (nih.gov)
  • Deleterious mutations in these genes are identified in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). (mdpi.com)
  • Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. (news-medical.net)
  • Diseases like autosomal dominant retinitis pigmentosa present a special challenge to researchers. (news-medical.net)
  • Rhodopsin is an important therapeutic target because mutations in it cause about 30 percent of autosomal dominant retinitis pigmentosa and 15 percent of all inherited retinal dystrophies. (news-medical.net)
  • Our hRPC programme currently focuses on two inherited retinal diseases, retinitis pigmentosa (RP) and cone rod dystrophy (CRD), hereditary diseases of the eye that lead to progressive loss of vision due to cells in the retina becoming damaged and eventually dying. (reneuron.com)
  • We have worked with world-leading collaborators and academic institutions in the retinal disease field to successfully take our retinitis pigmentosa programme through pre-clinical development. (reneuron.com)
  • Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. (springer.com)
  • Inherited retinal diseases-or IRDs-are a group of diseases that can cause severe vision loss or even blindness. (preventblindness.org)
  • This is Ben Shaberman, director of science communications, at the Foundation Fighting Blindness (FFB), and I'm pleased to present a quick overview of some of the exciting research advances for inherited retinal diseases made during 2017. (blindness.org)
  • The Foundation Fighting Blindness and 4D Molecular Therapeutics (4DMT), an innovative leader in viral vector development, have formed a partnership to help companies and researchers quickly obtain and implement high-quality vectors for their retinal gene-therapy development efforts. (blindness.org)
  • Our experimental results highlight the potential relevance of nanomaterials in the development of second-generation retinal prostheses to treat degenerative retinal blindness, and represents a major step forward," said Fabio Benfenati, the lead researcher, in a press release. (medgadget.com)
  • The function of cilia has not been understood, but patients with ciliopathies can suffer from a spectrum of problems including retinal blindness, obesity, renal failure, liver fibrosis and mental impairment. (ucsd.edu)
  • The group then tested whether mutations in genes might contribute to retinal blindness in other related diseases. (ucsd.edu)
  • The scientists found that patients carrying a particular genetic alteration were between five and ten times more likely to have retinal blindness, and that some forms of this blindness may be particularly amenable to gene therapy. (ucsd.edu)
  • This book provides comprehensive and up-to-date information on diagnosis, medical and surgical treatments for pediatric retinal vascular conditions, which are leading causes of childhood blindness throughout the world. (okian.ro)
  • Inherited retinal diseases are a group of rare disorders caused by one of more than 260 different genes, where mutation results in vision loss or blindness, often disproportionally affecting children and young adults. (pharmatimes.com)
  • Our human retinal progenitor cell (hRPC) programme for blindness-causing diseases of the retina is partnered with the Schepens Eye Research Institute Massachusetts Eye and Ear, an affiliate of Harvard Medical School in Boston, USA and a world-renowned clinical centre for the treatment of retinal diseases. (reneuron.com)
  • This free screening initiative offered by Spark Therapeutics gives eligible patients and their physicians easy access to laboratory testing for more than 30 disease-causing genes," said Steve Rose, chief research officer at Foundation for Fighting Blindness. (blindness.org)
  • In December 2017, Fighting Blindness welcomed the landmark approval of the first gene therapy for the eye and inherited retinal disease. (fightingblindness.ie)
  • Angiogenesis, the abnormal overgrowth of blood vessels, underlies many severe diseases, and when angiogenesis develops in the eye's retina it causes decreased vision and can even lead to blindness ," said Richard L. Sidman, the study's corresponding author. (diabetes.co.uk)
  • The incidence of blindness caused by retinal degenerative diseases is increasing at a rapid rate due to an increase in the global geriatric population, Wagner said. (uconn.edu)
  • Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. (springer.com)
  • While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2010. (springer.com)
  • We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume. (springer.com)
  • 3) It has been previously hypothesized that MCs in retinal degenerations exhibit deficient E transport. (utah.edu)
  • Most retinal degenerations and diseases can be diagnosed by a dilated eye examination. (oomc.com)
  • There are currently many gene therapy approaches being explored both in the lab and in on-going clinical trials for the treatment of inherited retinal degenerations. (fightingblindness.ie)
  • This trial seeks to prove the safety and efficacy of photothermal stimulation treatment to diabetic macular edema, chronic central serous retinopathy, macular edema secondary to branch retinal vein occlusion and macular telangiectasia. (clinicaltrials.gov)
  • This method will be used to treat macular diseases such as diabetic macular edema, branch retinal vein occlusion macular edema, chronic central serous retinopathy and macular telangiectasia. (clinicaltrials.gov)
  • On July 22, the first patient received treatment from the laser for proliferative diabetic retinopathy, the most severe stage of eye disease caused by diabetes. (healthcanal.com)
  • Diabetic Retinopathy - The deterioration of retinal blood vessels, called diabetic retinopathy, can lead to vision loss. (hines-sight.com)
  • Although considered one disease, there are many types of diabetic retinopathy. (hines-sight.com)
  • Widefield photography, OCT and OCT-A can play a critical role in helping us monitor for retinal changes in moderate to severe nonproliferative diabetic retinopathy, increase the frequency of follow up and discuss the importance of systemic control, smoking cessation and nutrition. (reviewofoptometry.com)
  • I have previously held the post of Clinical Lead of the Peterborough & Cambridgeshire Diabetic Eye Screening Service with responsibility for the clinical governance of the programme which delivered retinal screening to approximately 30,000 patients. (spirehealthcare.com)
  • Sidman and colleagues believe that Vasotide could be used to treat other retinal conditions in the future, including diabetic retinopathy. (diabetes.co.uk)
  • There are also increasing off-label use of bevacizumab (Avastin) for the management of various ophthalmologic diseases, like AMD, retinal vein occlusion and diabetic macular edema. (wikipedia.org)
  • https://journals.lww.com/jneuro-ophthalmology/Fulltext/2020/03000/Retinal_Vascul. (medworm.com)
  • The 2020 Ophthalmology Section's Lang Lecture will be given by Professor Robert MacLaren, an eminent professor at University of Oxford pioneering gene treatments for retinal disease. (rsm.ac.uk)
  • As The William F. Chatlos Professor of Ophthalmology at Harvard Medical School, he dedicated himself to clinical care and vision-saving research for people with inherited retinal diseases for five decades. (blindness.org)
  • Retinal bleeding has an occurrence rate of seven cases per 1,000 people, making it one of the most common causes of decreased vision, according to the American Academy of Ophthalmology. (reference.com)
  • The rarest form of the disease is caused by blood from an adjacent source, such as a tumor, reports the American Academy of Ophthalmology. (reference.com)
  • The standard treatment for retinal edema is topically applied NSAIDs, according to the Review of Ophthalmology. (reference.com)
  • aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Ophthalmology and Retinal Diseases in Pediatrics. (waset.org)
  • Also, high quality research contributions describing original and unpublished results of conceptual, constructive, empirical, experimental, or theoretical work in all areas of Ophthalmology and Retinal Diseases in Pediatrics are cordially invited for presentation at the conference. (waset.org)
  • ICORP 2022 has teamed up with the Special Journal Issue on Ophthalmology and Retinal Diseases in Pediatrics . (waset.org)
  • Ophthalmology evaluations on an annual basis are important to monitor disease progression and optimize your or your child's care, but their frequency may be modified based on the severity of the symptoms. (chop.edu)
  • Santen is a leading, multi-national ophthalmology company developing an innovative gene therapy product for the treatment of a significant inherited retinal disease affecting patients with few or no therapy options. (pharmatimes.com)
  • It should also be a hot topic in ophthalmology, particularly for retinal specialists. (ophthalmologytimes.com)
  • The recent expansion of our ophthalmology programmes into CRD is part of a broader strategy to evaluate the efficacy of our hRPC therapeutic candidate across a range of genetic diseases of the eye. (reneuron.com)
  • Our team of investigators in the Horae Gene Therapy Center and the Department of Ophthalmology & Visual Sciences is in a unique position to fulfill these requirements for developing treatments of retinal degenerative diseases," said Hemant Khanna. (biospace.com)
  • The IDentify Your Inherited Retinal Disease, or ID YOUR IRD, initiative was formally unveiled this week at the American Academy of Ophthalmology (AAO) 2016 Annual Meeting by Spark Therapeutics, a fully integrated gene therapy company seeking to transform the lives of patients with debilitating genetic diseases by developing investigational, potentially one-time, life-altering treatments. (blindness.org)
  • A confirmed genetic diagnosis is a critical gateway for patients with inherited retinal diseases and this initiative will help patients, caregivers and the medical community better understand their disease," said Mark Pennesi, M.D., Ph.D., associate professor of ophthalmology in the OHSU School of Medicine, OHSU Casey Eye Institute. (blindness.org)
  • This collaboration will accelerate translation of new treatments for currently incurable retinal diseases," said Peter Francis, SVP Clinical, Translational R&D, Program Leader, Ophthalmology Therapeutic Area of 4D Molecular Therapeutics. (biospace.com)
  • The aim of our study was to evaluate retinal parameters, measured with optical coherence tomography, as biomarkers of WFS progression. (diabetesjournals.org)
  • To investigate the role of retinal thinning for visual hallucination in PD, we conducted a case-control study using spectral domain optical coherence tomography. (nih.gov)
  • To determine whether retinal abnormalities, as measured by high definition optical coherence tomography (HD-OCT) and visual electrophysiology techniques can be used as a clinical biomarker to monitor disease progression overtime in patients with Parkinson disease. (clinicaltrials.gov)
  • A full-thickness retinal break, which may lead to total rhegmatogenous retinal detachment, may occur. (medscape.com)
  • Normal blood vessel hemorrhage occurs when trauma damages an element of the eye, as occurs in retinal detachment. (reference.com)
  • Retinal Detachment - A retinal detachment is a condition where the tissues of the retina separate from the back of the eye. (hines-sight.com)
  • A retinal surgeon stiches a silicone material to the outside of the eye when there's a retinal detachment, which buckles the sclera and causes a decrease in the circumference of the eye and re-attaches the retina. (oomc.com)
  • A surgeon will perform pars plana vitrectomy (PPV) or scleral buckling to treat a complex retinal detachment. (oomc.com)
  • The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal detachment), presenting as: Blurred vision Blind spots Specks in your vision Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus retinitis. (wikipedia.org)
  • Proliferative vitreoretinopathy has been observed in cases of retinal detachment. (wikipedia.org)
  • Often individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir. (wikipedia.org)
  • Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil endotamponade. (wikipedia.org)
  • An adverse effect of this is retinal detachment (and vitreous hemorrhage), also there is no systemic beneficial effect for cytomegalovirus organ disease. (wikipedia.org)
  • The manual is of value to a wide range of practitioners and trainees, including students,residents, fellows and ophthalmologists who treat retinal diseases. (springer.com)
  • A stable small peptide that binds to two retinal VEGF receptors blocks angiogenesis in animal models of human retinal diseases. (sciencemag.org)
  • In the February 22 issue of Cell , they describe a platform that uses big data and AI not only to recognize two of the most common retinal diseases but also to rate their severity. (eurekalert.org)
  • Clinical study of the inflammatory involvement in common retinal diseases, including the targeting inflammation and microglial activation as a therapeutic strategy in proof-of-concept Phase I/II clinical trials. (nih.gov)
  • The investigators hope that finding the genetic cause will increase understanding of more common retinal diseases. (rpbusa.org)
  • This is a differentiated approach that would potentially allow the use of AAV vectors for the treatment of orphan degenerative retinal diseases such as Leber Congenital Amaurosis (LCA) type 10 due to CEP290 mutations (the most common type of LCA), and autosomal recessive Stargardt disease (STGD1) due to ABCA4 mutations. (biospace.com)
  • The collaboration will combine the complementary expertise of 4D Molecular Therapeutics with the Casey Eye Institute and the Oregon National Primate Research Center to identify and develop gene therapies for degenerative retinal diseases. (biospace.com)
  • The laser provides treatment for various rare eye diseases, including retinal vein occlusion, neovascular glaucoma, and retinal tears. (healthcanal.com)
  • Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? (medworm.com)
  • Only a few published case reports have referred to occlusion of retinal arteries or veins in SSc. (bmj.com)
  • The damage to the small blood vessels there causes leakage of fluid Pseudophakic cystoid macular edema Macular edema secondary to retinal vein occlusion Macular edema secondary to uveitis Infections, such as endophthalmitis and retinitis Noninfectious vitritis Sometimes, an intravitreal injection of antibiotics and steroids is given as part of routine cataract surgery. (wikipedia.org)
  • We offer quality both medical and surgical treatment plans for retinal diseases. (utah.edu)
  • Promising gene therapies for inherited retinal diseases (IRDs) - many of which have moved into clinical trials - use viral delivery systems (aka vectors) to get copies of the therapeutic gene to the retinal cells that need them. (blindness.org)
  • The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer's disease. (ingentaconnect.com)
  • Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, including subclinical and clinical CeVD. (medworm.com)
  • We have identified 4 related NHPs at the California National Primate Research Center with visual impairment and findings from clinical ophthalmic examination, advanced retinal imaging, and electrophysiology consistent with achromatopsia. (jci.org)
  • Tool for Evaluating RWE in the Treatment of Retinal Disease Randomized clinical trials have long been held as the gold standard for evidence based medical practices. (globalrph.com)
  • This book is a comprehensive source of authoritative information on the clinical features,diagnosis, differential diagnosis, and management of medical and surgical retinal diseases. (springer.com)
  • To test clinical efficacy of sub-visible retinal therapy using ms-range exposures of visible lasers one needs first to establish proper titration methods necessary to assure on one hand the lack of tissue damage, and on the other hand sufficient hyperthermia to elicit cellular response. (clinicaltrials.gov)
  • Clinical trials may be discussed that test novel therapies to target mitochondrial retinal or optic neuropathy disorders. (chop.edu)
  • The aim of the collaboration is to generate pre-clinical proof of concept to treat an inherited retinal disease with lentiviral vectors developed and manufactured by Oxford Biomedica, and includes a licence to use the company's LentiVector platform. (pharmatimes.com)
  • Pre-clinical studies have demonstrated that retinal implantation of human retinal progenitor cells (hRPC) have the potential to preserve existing photoreceptors, potentially reducing or halting further deterioration of vision. (reneuron.com)
  • Pre-clinical studies carried out in disease models by the Company's academic collaborators have demonstrated that, when transplanted into the retina, our retinal progenitor cell technology has the potential to preserve existing photoreceptors, potentially reducing or halting further deterioration of vision. (reneuron.com)
  • The synergy between Dr. Gao's highly recognized team of experts in gene therapy at the University of Massachusetts Medical School and Ophthotech's clinical expertise has the potential to fulfill of our commitment to advance innovative solutions for the treatment of retinal diseases. (biospace.com)
  • The Pangere Center provides exemplary patient care through specialized testing, clinical research and evaluation, and accurate diagnoses of various inherited retinal diseases. (chicagolighthouse.org)
  • Designate your donation to the Pangere Center to support specialized patient testing and evaluations, research studies (including clinical trials) and the training of retinal specialists. (chicagolighthouse.org)
  • The molecular mechanisms are very different in each case but the clinical impact on the development of the disease is the same. (healthcanal.com)
  • Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study. (cdc.gov)
  • Clinical significance was further evaluated by determination of IRS-1 expression in monkey and human retinal biopsy specimens. (nih.gov)
  • Together, these findings support the clinical testing of aganirsen for human retinal neovascular diseases. (nih.gov)
  • The mission of our section (NGIRDS) is to explore and understand the fundamental biological mechanisms underlying retinal diseases and translate these findings into proof-of-concept clinical studies to discover new therapies. (nih.gov)
  • Additionally, to analyse the association of retinal disease with other clinical/laboratory findings, particularly the findings of nailfold capillaries in patients with SSc. (bmj.com)
  • a clinical stage biotech company, developing RNA therapies for genetic retinal disease including Usher syndrome. (fightingblindness.ie)
  • BioTime, Inc. (NYSE MKT:BTX), a clinical-stage biotechnology company developing and commercializing products addressing degenerative diseases, today announced that the company has obtained a world-wide license to intellectual property (IP) assets from University of Pittsburgh . (businesswire.com)
  • We propose to measure retinal nerve fiber density in these patients considering them as 'pre-motor' PD and follow their clinical evolution overtime. (clinicaltrials.gov)
  • Retinal changes were assessed from photographs by graders masked to clinical data. (ahajournals.org)
  • HealthDay News) - Patients with multiple sclerosis (MS) with clinical or radiologic nonocular disease activity have accelerated ganglion cell/inner plexiform (GCIP) layer thinning, according to a study published in the Jan. 1 issue of Neurology . (empr.com)
  • Clinical Infectious Diseases. (wikipedia.org)
  • What are Inherited Retinal Diseases (IRDs)? (preventblindness.org)
  • Though the U.S. Food & Drug Administration (FDA) is more tightly regulating U.S. clinics that tout stem-cell trials and treatments for inherited retinal diseases (IRDs) and a host of other conditions, many significant loopholes and enforcement limitations remain. (blindness.org)
  • For anyone wanting to know about the latest clinically focused research for inherited retinal diseases (IRDs), the Innovation Summit for Retinal Cell and Gene Therapy was the place to be. (blindness.org)
  • The purpose of this study is to find out whether color vision measured with the Cambridge Color Test is a good way to examine the severity of inherited retinal diseases (IRDs). (clinicaltrials.gov)
  • IRDs are a major cause of vision loss worldwide, but very little is known about how the diseases affect color vision over time. (clinicaltrials.gov)
  • PHILADELPHIA, Oct. 13, 2016 (GLOBE NEWSWIRE)-Spark Therapeutics (NASDAQ: ONCE) will provide physicians and eligible patients access to genetic testing and counseling for more than 30 genes linked to certain forms of inherited retinal diseases (IRDs), a group of eye conditions believed to affect more than 100,000 people in the United States. (blindness.org)
  • People with IRDs are encouraged to seek testing even if they have previously been tested for a genetic disease. (blindness.org)
  • Inherited retinal diseases (IRDs) are retinal conditions that are passed down through family members. (physiciansweekly.com)
  • Because IRDs are associated with specific gene mutations and may have similar symptoms to other retinal conditions, it is important that patients receive genotype testing to confirm a specific diagnosis. (physiciansweekly.com)
  • To view and listen to Ben Shaberman's presentation of "Top Retinal Research Advances for 2017," with full slides and audio, click here . (blindness.org)
  • Because the retina is essential to vision, many people with retinal diseases usually realize they have a problem when the disease begins affecting the quality of their vision. (utah.edu)
  • This fluid, called Vitreous Gel, can cause a retinal tear. (oomc.com)
  • An injection of gas may also be necessary, along with a laser to seal the retinal tears, and the vitreous cavity may then be filled with a medical gas or silicone oil to help with healing. (oomc.com)
  • Albert T. Vitale specializes in the medical and surgical treatment of patients suffering from diseases of the retina and vitreous. (utah.edu)
  • Get the inside scoop on this year's top research advances and what's next in retinal disease science by watching VISIONS 2018 LIVE! (blindness.org)
  • To study the ocular disease without the complications of the kidney disease, naturally occurring point mutations of human CLDN19 were recreated in human induced pluripotent cells or overexpressed in the retinae of newborn mice. (nature.com)
  • We chose the G20D and R81W mutations because they are examples of more severe (G20D) and less severe (R81W) disease 11 . (nature.com)
  • Herein, we discuss the pathology of 11- cis -retinal deficiency caused by these mutations in both animal disease models and human patients. (mdpi.com)
  • Background: Autosomal recessive bestrophinopathy (ARB) is one of 5 blinding eye diseases caused by mutations in the gene BEST1. (clinicaltrials.gov)
  • Objective: To collect DNA/RNA and skin samples from individuals with ARB or other diseases due to mutations in the gene BEST1. (clinicaltrials.gov)
  • Retinal disease in Usher syndrome III caused by mutations in the clarin-1 gene. (nih.gov)
  • To determine the retinal phenotype of Usher syndrome type III (USH3A) caused by clarin-1 (CLRN1) gene mutations in a non-Finnish population. (nih.gov)
  • Inherited retinal diseases are ideal candidates for gene therapy because many of the responsible genetic mutations have already been identified. (pharmatimes.com)
  • Genetic retinal diseases occur when there are misspellings (or mutations) in your DNA. (fightingblindness.ie)
  • LUXTURNA (voretigene neparvovec-rzyl) is now approved in the United States for the treatment of patients with inherited retinal disease due to DNA mutations in both copies of the RPE65 gene. (fightingblindness.ie)
  • Once inside, they settle down and can then be used to electrically activate existing retinal neurons when light strikes the nanoparticles. (medgadget.com)
  • Enclosing the photoactive polymers in particles that are smaller than the photoreceptors increases the active surface of interaction with the retinal neurons, and allows to easily cover the entire retinal surface and to scale the photoactivation at the level of a single photoreceptor. (medgadget.com)
  • There is already a body of evidence that retinal neurons accumulate alpha-synuclein and degenerate in Parkinson disease (PD). (clinicaltrials.gov)
  • Further investigation revealed that retinal photoreceptor cells in the mouse model were most likely dying as a result of a toxic accumulation of the very photopigment that receives light signals in the eye and is crucial for normal vision. (ucsd.edu)
  • Photoreceptor layer loss and features of retinal remodeling were present in retinal regions with severe visual dysfunction, even at the youngest ages tested. (nih.gov)
  • Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease. (petmd.com)
  • To quantify and correlate ellipsoid zone and photoreceptor outer segment changes with visual acuity in Stargardt disease. (ovid.com)
  • The timing and varying location of these meetings provides an important assembly for investigators from throughout the world to convene for presentation of their new findings on the causes and potential therapies for degenerative retinal disorders. (springer.com)
  • In Animal Models for Retinal Diseases , recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. (springer.com)
  • The therapeutic potential of CoQ10 for other retinal diseases was also discussed. (ingentaconnect.com)
  • The images are from a Cincinnati Children's study published in Nature that researchers say has possible therapeutic implications for diseases of the retina and cancer. (cincinnatichildrens.org)
  • Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina - a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. (cincinnatichildrens.org)
  • Curcumin as a Therapeutic Option in Retinal Diseases. (greenmedinfo.com)
  • Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties. (greenmedinfo.com)
  • These models will be used to identify and test therapeutic approaches to treating these diseases. (clinicaltrials.gov)
  • Their novel Therapeutic Vector Evolution AAV platform holds huge promise for patients with inherited retinal dystrophies and related conditions. (biospace.com)
  • The answers are central to elucidating the basic function of microglia and are relevant to establishing a foundation for the development of therapeutic approaches aimed at microglial modulation as a strategy for retinal diseases. (nih.gov)
  • If OCT proves useful as a means to identify pre-motor PD, such a result would present an important therapeutic window to intervene with disease modifying drugs and to prevent the development of CNS deficits. (clinicaltrials.gov)
  • Ocular findings in sickle cell disease patients in Lagos. (medscape.com)
  • Their findings, which may lead to new therapies and improved diagnostics for retinal disease, will appear online in advance of publication in the journal Nature Genetics on January 17. (ucsd.edu)
  • Prospective studies with larger cohorts will be useful to corroborate our findings and also to determine if there is progression in the abnormalities in the foveal avascular zone identified in the current cohort and if there is any association of the retinal vasculature with onset or progression of dementia," study co-author Rajendra S. Apte, MD, PhD, told Healio.com/OSN. (healio.com)
  • Participants with preclinical biomarkers for Alzheimer's disease had a mean foveal avascular zone of 0.364 mm² compared with a mean 0.275 mm² for those with biomarker negative findings ( P = .002). (healio.com)
  • In light of these findings, the objective of this study was to examine the visual field in psoriatic patients without any pathology of the retina and/or optic nerve with the aim of evaluating retinal sensitivity. (scielo.br)
  • Expanding the spectrum of Ebola-associated eye disease: a summary of ocular findings in a large cohort of Ebola survivors. (cdc.gov)
  • To determine the prevalence of retinal disease in systemic sclerosis (SSc) and to characterise the findings of retinopathy. (bmj.com)
  • The patients with SSc were divided into two groups according to the retinal findings. (bmj.com)
  • Our findings suggest that retinal changes in MS reflect global central nervous system processes, and that OCT-derived GCIP thickness measures may have utility as an outcome measure for assessing neuroprotective agents, particularly in early, active MS," the authors write. (empr.com)
  • This highly collaborative project combined genetic, molecular, whole animal approaches with bioengineered nanoscaffold models of glaucoma and drug discovery to show that activation of the channel mimics the trabecular changes in glaucoma whereas elimination of the TRPV4 gene or systemic exposure to TRPV4 inhibitors protected mice from the disease. (utah.edu)
  • causes for these disorders, but more research is needed to understand why patients with these particular genetic alterations have such variable diseases," said Joseph G. Gleeson, MD, professor of neurosciences and pediatrics at UC San Diego and Howard Hughes Medical Institute Investigator, who supervised the work. (ucsd.edu)
  • As routine sequencing of the human genome becomes more and more feasible, studies like ours will help pinpoint which genetic alterations increase the risk of having a certain disease, or the likelihood that your children will have the disease. (ucsd.edu)
  • In veterinary medicine, we tend to lump them all together under the term progressive retinal atrophy (PRA) even though research has identified some of the specific genetic defects that are responsible. (petmd.com)
  • While deciding to be tested is always a personal decision between patients and their physicians, this type of information can identify the underlying genetic cause of a person's retinal disease and help them understand how the disease may affect their vision over their lifetime. (blindness.org)
  • The European Commission has given its seal of approval for use of the one-time gene therapy to treat patients with vision loss due to a genetic mutation in both copies of the RPE65 gene, if they have enough viable retinal cells. (pharmatimes.com)
  • Retina disease can be genetic or related to aging, diabetes, trauma or other chronic conditions. (oomc.com)
  • 4DMT is focused on the discovery and development of targeted, customized and proprietary next-generation AAV gene therapy products for use in patients with severe genetic diseases with high unmet medical need. (biospace.com)
  • These proprietary and targeted products allow us to treat both rare genetic diseases and complex large market diseases. (biospace.com)
  • Behcet's disease with retinal vascular lesions. (bmj.com)
  • Smith R. B. , Prior I. A. , Sturman D. . Behcet's disease with retinal vascular lesions. (bmj.com)
  • In particular, "efficacy studies have shown that the reduction of NRARP in the retina by means of siRNA leads to the regression of angiogenic retinal lesions and that the observed reductions are equivalent to those of anti-VEGF, which is the current treatment standard for these diseases with ocular injections", stresses the R&D manager. (eurekalert.org)
  • Possible reasons for exclusion included the following: a history of neurological diseases, space-occupying lesions, optic neuropathy, high refractive errors, glaucoma, retinal pathology, color vision defects and cataracts, the use of systemic and/or topical retinoic acid or immunosuppressive medication, and undergoing ultraviolet therapy. (scielo.br)
  • Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised by cutaneous and visceral fibrosis and proliferative intimal lesions of the small arteries, leading to an obliterative vasculopathy. (bmj.com)
  • At the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology), scientists have now come up with an injectable retinal prosthesis that does away with all the complexity and works directly to take over the function of diseased photoreceptors. (medgadget.com)
  • Mitochondrial retinal disease and optic neuropathy may occur when mitochondria in the photoreceptors and nerves in the eye are disrupted. (chop.edu)
  • This newly found retinal disease causes abnormal blood vessels in the macula, and these vessels are prone to bleeding. (rpbusa.org)
  • Intravitreal injection is used to inject a drug into the eye to reduce inflammation (anti-inflammatory), inhibit the growth and development of new blood vessels (angiostatic), or lower the permeability of blood vessels (anti-permeability), in turn curing various eye diseases. (wikipedia.org)
  • We treat and diagnose a wide variety of retinal diseases. (hines-sight.com)
  • The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. (springer.com)
  • Gene therapy for retinal disease is the next class of medicines to become available to patients. (rsm.ac.uk)
  • This unique lecture will update you on current progress and future developments of gene therapy for retina diseases. (rsm.ac.uk)
  • Oxford Biomedica and Santen have announced plans to enter into a research and development collaboration and option & licence agreement for development of gene therapy vectors for inherited retinal disease. (pharmatimes.com)
  • We look forward to working together with Santen in a true parternship that will bring to bear our respective capabilities in gene therapy vectors and inherited retinal diseases to maximise the value of this important R&D programme. (pharmatimes.com)
  • This new research is even more promising since it revealed that gene therapy could protect and even improve the dogs' vision when it was started in the later stages of the disease, after 50% or more of the rods and cones had already been lost. (petmd.com)
  • NEW YORK--( BUSINESS WIRE )-- Ophthotech Corporation (NASDAQ:OPHT) announced today that the Company has initiated an innovative gene therapy research collaboration focused on applying novel gene therapy technology to discover and develop next-generation therapies for the treatment of ocular diseases. (biospace.com)
  • As part of Ophthotech's strategy, the Company has entered into a series of sponsored research agreements with the University of Massachusetts Medical School and its Horae Gene Therapy Center to utilize their "minigene" therapy approach and other novel gene delivery technologies to target retinal diseases. (biospace.com)
  • Advances in gene therapy technologies have been promising and may provide transformational, next-generation therapies for patients with ophthalmic disease," stated Glenn P. Sblendorio, Chief Executive Officer and President of Ophthotech. (biospace.com)
  • Researchers seeking cures to diseases of the eye have led the way in innovation in gene therapy," said Terence R. Flotte, MD, executive deputy chancellor, provost and dean of the school of medicine at the University of Massachusetts Medical School, and a specialist in the field of gene therapy who was the first to use adeno-associated virus as a vehicle to deliver corrective genes in humans. (biospace.com)
  • The collaboration with UMass Medical School will also focus on developing the next generation of gene therapy vectors to allow novel delivery approaches for treatment of retinal diseases. (biospace.com)
  • Gene therapy and bioengineering for retinal diseases: what is the future? (epfl.ch)
  • For Aim 1, color discrimination thresholds (CCT and LvCCT) and assessments of retinal structure (imaging) and function (perimetry/microperimetry and electroretinogram) will be measured in 144 IRD participants with varying retinal phenotypes and visual acuities. (clinicaltrials.gov)
  • Microscopic inner retinal hyper-reflective phenotypes in retinal and neurologic disease. (nih.gov)
  • He explains that diagnosing and treating retinal diseases normally involves visiting a general medical doctor or an optometrist, then a general ophthalmologist, and finally a retina specialist. (eurekalert.org)
  • At the Moran Eye Center we are leaders and innovators in diagnosing and treating retinal diseases and retinal surgery. (utah.edu)
  • Mount Sinai offers expertise in the diagnosis and treatment of retinal disease. (mountsinai.org)
  • Digital retinal imaging is widely used to identify patients with retinal disease in primary care. (embs.org)
  • With the advent of the latest screening technology, the advantage of using ultra wide field scanning-laser ophthalmoscope (SLO) is its wide field of view of the retina making it a valuable tool in the management of patients with retinal disease. (embs.org)
  • Better managing patients with retinal disease begins with establishing a relationship with a retina specialty practice. (reviewofoptometry.com)
  • The severity and how fast the disease progresses can vary from person to person with RP, depending on the gene affected. (preventblindness.org)
  • Degree of severity of retinal dysfunction in IRD participants will be determined relative to the normal ranges obtained from the healthy volunteers (see Aim 3a below). (clinicaltrials.gov)
  • With EyesFirst, clinicians could compare a patient's history of OCT images to assess disease severity and track disease progression. (mitre.org)
  • There were no significant correlations between retinal thicknesses and duration or severity of PD and medication dosages. (nih.gov)
  • The severity was determined using the Psoriasis Area and Severity Index and the duration of the disease was recorded. (scielo.br)
  • There were correlations between disease severity and the mean deviations in standard achromatic perimetry and short wavelength automated perimetry and between disease severity and the corrected pattern standard deviation and pattern standard deviation of short wavelength automated perimetry (r = -0.363, r = -0.399, r = 0.515 and r = 0.369, respectively). (scielo.br)
  • Retinal sensitivity appears to be affected by the severity of psoriasis vulgaris. (scielo.br)
  • Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study. (springer.com)
  • The compounds currently used to treat these diseases are based on large antibodies that cannot penetrate from the ocular surface to the retina, so they must be administered by intravitreal injections. (eurekalert.org)
  • Psoriasis is a hyperproliferative chronic inflammatory skin disease of unknown etiology and ocular structures and visual pathways can also be affected during the course of this disease. (scielo.br)
  • Spire Cambridge Lea Hospital provides excellent facilities for the management of ocular disease with state-of-the-art technology supporting modern ophthalmic surgical and outpatient practice. (spirehealthcare.com)
  • Prevalence of retinal scar lesion types in a case-control study of ocular signs in Ebola virus disease survivors, Sierra Leone, 2016. (cdc.gov)
  • He is also one of about a handful of people in the country with dual training in ocular immunology and inflammatory disease as well as vitreoretinal surgery, and the only provider of such expertise in the Intermountain West. (utah.edu)
  • Alzheimer's disease (AD) is the major cause of dementia in the world. (ingentaconnect.com)
  • Current Alzheimer Research publishes peer-reviewed frontier review and research articles on all areas of Alzheimer's disease. (ingentaconnect.com)
  • This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer's disease. (ingentaconnect.com)
  • Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. (ingentaconnect.com)
  • The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer's disease. (ingentaconnect.com)
  • Subjects with preclinical Alzheimer's disease had a larger foveal avascular zone and decreased inner foveal thickness compared with subjects without preclinical Alzheimer's disease. (healio.com)
  • Researchers evaluated the OCTA measurements to determine if early retinal alterations could be detected in subjects with preclinical Alzheimer's disease . (healio.com)
  • A fluorescence image of retinal layers taken with a confocal microscope from wild, healthy mice (right) and mice genetically bred to show symptoms of Alzheimer's disease (left). (nih.gov)
  • The green represents amyloid deposits that are thought to correlate with Alzheimer's disease. (nih.gov)
  • The advance could be used to detect a biomarker of Alzheimer's disease, potentially offering a widespread early warning system for the disease. (nih.gov)
  • Diagnoses of Alzheimer's disease are currently only made after a patient begins to show symptoms of cognitive decline. (nih.gov)
  • Diagnosis or history of Alzheimer's disease, dementia or neurodegenerative disorders. (pfizer.com)
  • The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). (frontiersin.org)
  • In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. (utah.edu)
  • Major breakthroughs in the past few years have linked many forms of these diseases with defects in the structure or signaling capacity of the cilia in cells as diverse as retinal, fat, kidney, liver and nerve cells. (ucsd.edu)
  • Inner retinal images from 101 subjects affected by one of 38 retinal or neurologic conditions and 11 subjects with no known eye disease were examined for the presence of hyper-reflective features other than vasculature, retinal nerve fiber layer, and foveal pit reflex. (nih.gov)
  • Measurements such as retinal nerve fiber layer thickness, inner and outer foveal thickness, and foveal avascular zone were taken with OCT angiography (OCTA). (healio.com)
  • As the retina and optic nerve use a great amount of energy, it's not uncommon for vision to be affected by mitochondrial disease. (chop.edu)
  • For example, the thickness profile of the Retinal Nerve Fibre Layer - which can be calculated directly from the segment layer - is used in the diagnosis of glaucoma, which is one of the most common causes of sight-loss world-wide. (voice-online.co.uk)
  • In a comparison between patients with PD and healthy controls, there was significant parafoveal inner nuclear layer thinning, whereas other retinal layers, including the retinal nerve fiber layer, as well as total macular thicknesses were not different. (nih.gov)
  • In terms of visual hallucinations among the PD subgroups, only retinal nerve fiber layer thickness differed significantly, whereas total macular thickness and the thickness of other retinal layers did not differ. (nih.gov)
  • The retinal nerve fiber layer was thinnest in the group that had hallucinations without dementia, followed by the group that had hallucinations with dementia, and the group that had no hallucinations and no dementia. (nih.gov)
  • The results indicate that retinal nerve fiber layer thinning may be related to visual hallucination in nondemented patients with PD. (nih.gov)
  • Oxidative stress can lead to pathological processes, like cell apoptosis, angiogenesis and inflammation ending in retinal pathologies. (greenmedinfo.com)
  • Besides its role in barrier function, claudin-19 regulates the expression of RPE signature genes 16 , 17 that include visual cycle proteins and retinal neurotrophic factors. (nature.com)
  • But as incredible as genome surgery is, CRISPR has some flaws to overcome before it can live up to its hype of curing disease in humans by simply cutting out bad genes and sewing in good ones. (news-medical.net)
  • The viruses "infected" the dogs' retinal cells and inserted these functional genes. (petmd.com)
  • Currently, there is no effective treatment or cure for mitochondrial retinal or optic neuropathy disorders. (chop.edu)
  • Antioxidant therapies may be prescribed for some causes of mitochondrial retinal or optic neuropathy disorders. (chop.edu)
  • Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration. (nih.gov)
  • In this study, the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal neovascularization. (nih.gov)
  • IRD participants will be divided into four major categories: 1) cone & cone-rod dystrophies, 2) rod-cone dystrophies, 3) inherited maculopathies, and 4) inherited retinal dysfunction syndromes. (clinicaltrials.gov)
  • This same tool might work in hundreds of diseases, including Huntington's disease, Marfan syndrome, and corneal dystrophies. (news-medical.net)
  • This database could enable correlations between retinal changes and the onset and progression of chronic disease, leading to the identification of novel disease predictors. (mitre.org)
  • Optometrists can help slow disease progression and appropriately monitor and refer patients to a multitude of specialists-including those within our own ranks. (reviewofoptometry.com)
  • Whether retinal imaging could be useful as an objective biomarker to track disease progression and response to disease-modifying treatments in patients with PD is not known. (clinicaltrials.gov)
  • We hypothesize that patients with PD have specific patterns of damage in retinal structure and function, that this pattern can be identified in the premotor phase, We believe that OCT can be used as an objective biomarker of premotor diagnosis and disease progression. (clinicaltrials.gov)
  • Current treatments only succeed in slowing the progression of disease. (uconn.edu)
  • This is a pilot study which suggests that changes in the retinal vasculature and retinal thickness can be detected very early in disease prior to any evidence of cognitive decline. (healio.com)
  • Average retinal thickness and central thickness were measured using three-dimensional disc and macula scans covering a retinal area of 6 × 6 mm. (diabetesjournals.org)
  • Total macular thickness and the thickness of each retinal layer on horizontal scans through the fovea were compared between the groups. (nih.gov)
  • OCT quantifies the thickness of the different retinal layers. (clinicaltrials.gov)
  • But today, innovative diagnostic testing and breakthrough therapies allow optometrists to focus on retinal disease as a key aspect of our practices. (reviewofoptometry.com)
  • Filtering blue light reduces light-induced oxidative stress, senescence and accumulation of extracellular matrix proteins in retinal cells. (greenmedinfo.com)
  • This video abstract depicts how artificial intelligence takes on disease diagnosis in a new study from Zhang and colleagues where a deep-learning framework is utilized to develop an image-based diagnostic. (eurekalert.org)
  • Early diagnosis of individuals with chronic disease is a global health goal because the sooner a physician can detect a disease in a patient, the better the prognosis. (mitre.org)
  • OCT machines are used by ophthalmologists to produce non-invasive three-dimensional photographs of a patient's retina, which are used in the diagnosis of eye-related disease. (voice-online.co.uk)
  • Diagnosis of dry AMD as defined by the Age-Related Eye Disease Study (AREDS, 2005), including uni- or multi-focal GA, without foveal involvement. (pfizer.com)
  • Diagnosis or recent history of clinically significant cerebrovascular disease. (pfizer.com)
  • He is also one of the only ophthalmologists in the Intermountain West specializing in the diagnosis and treatment of uveitis and other infections and inflammatory diseases of the eye. (utah.edu)
  • Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human conditions, are necessary to more efficiently advance new therapies for patients. (jci.org)
  • As part of the federal government's National Institutes of Health (NIH), the National Eye Institute's mission is to "conduct and support research, training, health information dissemination, and other programs with respect to blinding eye diseases, visual disorders, mechanisms of visual function, preservation of sight, and the special health problems and requirements of the blind. (nih.gov)
  • These data suggest that retinal microvascular signs have specific associations with large cerebral vessel disease. (ahajournals.org)
  • How are proliferative retinal changes characterized in sickle cell disease (SCD)? (medscape.com)
  • All of this further helps us make timely referrals for patients at risk for vision loss due to DME or proliferative disease. (reviewofoptometry.com)
  • Retinal Vasculature in Development and Diseases. (harvard.edu)
  • A retinal examination uses bright light and lenses to examine the retina in both eyes and check for tears or detachments. (oomc.com)
  • Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be atrophic). (wikipedia.org)