A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.
The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.
Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.
A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Exclusive legal rights or privileges applied to inventions, plants, etc.
Three individuals derived from three FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Freedom of equipment from actual or potential hazards.
Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.
A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
Conjugation results in a lower pKa. This results in the conjugated bile acids being ionized at the usual pH in the intestine, ... CDCA and other bile acids form micelles, which facilitate lipid digestion. After absorption, they are taken up by the liver and ...
Lastly, micelles result from electrostatic interaction between nucleic acids and copolymers. Chemokines are used in the ... The nanoparticles currently used in experimental trials are usually nanoplexes, polyplexes, lipoplexes, or micelles. These four ...
Detergent micelles will also bind the dye and increase background noise dramatically. This effect is lessened by switching to ... The resulting chromatogram allows the researcher to estimate the dispersity and expression level of the tagged protein in the ... When the protein unfolds, the exposed hydrophobic surfaces bind the dye, resulting in an increase in fluorescence by excluding ... Intrinsic fluorescence lifetime works with membrane proteins and detergent micelles but a powerful UV fluorescer in the buffer ...
As a result of its hydrocarbon tail, and its anionic "head group", it has amphiphilic properties that allow it to form micelles ... "Precision Relative Aggregation Number Determinations of SDS Micelles Using a Spin Probe. A Model of Micelle Surface Hydration ... The critical micelle concentration (CMC) in pure water at 25 °C is 8.2 mM, and the aggregation number at this concentration is ... The micelle ionization fraction (α) is around 0.3 (or 30%). SDS is synthesized by treating lauryl alcohol with sulfur trioxide ...
Oxygen oxidises the Cu(I) to Cu(II) which impedes the reaction and results in low yields. One of the more commonly used Cu ... In water the biohybrid micelles with a diameter of 30 to 70 nanometer form aggregates. The use of a Cu catalyst in water was an ... However, better results are observed with the pentamethylcyclopentadienyl(Cp*) version. This may be due to the sterically ... The CuAAC click reaction also effectively couples polystyrene and bovine serum albumin (BSA). The result is an amphiphilic ...
As a result, the surfactant monomers and micelles migrate quite slowly, though their net movement is still toward the cathode. ... they will migrate toward the cathode at a higher velocity than that of the negatively charged micelles. Mixed micelle systems, ... Analytes that solubilize completely within the micelles (analytes that are highly hydrophobic) should migrate at the micelle ... The anionic character of the sulfate groups of SDS cause the surfactant and micelles to have electrophoretic mobility that is ...
... micelles) as well. This phenomenon is important because they predict that in the presence of ethanol the micelles can serve as ... The results are depicted in the simulations and supported by mass density profiles as well. The mass density profiles show the ... The results are supported by the simulations which show that at approximately 12 mol% of ethanol the membrane was no longer ... Another example is the formation of micelles which has a non-lamellar formation in which the hydrophilic region is ...
As a result, these two fluids have very different applications. The magnetic particles, which are typically micrometer or ... Addition of a surfactant allows micelles to form around the ferroparticles. A surfactant has a polar head and non-polar tail ( ... This results in an increased mobility and agility for the patient. Smart fluid Ferrofluid Electrorheological fluid Rheology ... These modes involve, respectively, fluid flowing as a result of pressure gradient between two stationary plates; fluid between ...
... resulting in the delivery of bile into the duodenal part of the small intestine. Bile salts form amphipathic lipids, micelles ...
These results suggest that they could be used in medicine without risk of biocompatibility issues and thus potentially lead to ... The way spiders produce spidroin in micelles has inspired a method of mass producing recombinant proteins. By fusing a pH- ...
Nippon Kayaku Announces FDA Orphan Drug Designation to New Polymeric micelle Anti-Cancer Drug NK012 for Small Cell Lung Cancer ... ". "Search of: NK012 - List Results - ClinicalTrials.gov". www.clinicaltrials.gov. Retrieved 2020-11-28. ... NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite). NK012 is an SN-38-releasing polymeric micelle ... 2008). "Novel SN-38-Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression ...
... micelles). The resulting equation solved for capacity factor in terms of partition coefficients is much the same as that of ... The addition of micelles to the mobile phase introduces a third phase into which the solutes may partition. Micelles are ... The solute will partition between the water and the stationary phase (KSW), the water and the micelles (KMW), and the micelles ... Many of the characteristics of micelles differ from those of bulk solvents. For example, the micelles are, by nature, spatially ...
... the resulting amphiphilic polymer-protein conjugate is capable of reversible self-assembly into micelles. In addition to ... The resulting hybrid catalyzes the hydrolysis of glycoside when irradiated by 350 nm UV light, but turns inactive under 420 nm ... Micelles refers to a type of supramolecular structure consisting of amphiphilic molecules self-assemblies, usually hollow ... The resulting nanoparticles show excellent encapsulation capability for both hydrophobic and hydrophilic molecules, such as ...
However, in sharp contrast to surfactant micelles, the interior of a casein micelle is highly hydrated. The caseins in the ... As a result, it has relatively little tertiary structure. It is relatively hydrophobic, making it poorly soluble in water. It ... Any of several molecular models could account for the special conformation of casein in the micelles. One of them proposes the ... Holt C (1992). "Structure and Stability of Bovine Casein Micelles". In Anfinsen CB, Richards FM, Edsall JT, et al. (eds.). ...
... which results in bacterial cell death. It has been proposed that the formation of spherical micelles by daptomycin may affect ... Each KS catalytic cycle results in the net addition of two carbons. After three more iterations of elongation, a thioesterase ... This causes rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA, and RNA ... Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride" (PDF). ChemPhysChem. 17 (14): 2118-22. doi: ...
This can result in multiple particles within each micelle, which may negatively impact overall resolution. For this reason ... Generally, two end groups result in the highest conversion into micelles (91%): C 10 F 21 {\displaystyle C_{10}F_{21}} C 8 F 17 ... Once solubilized by encapsulation in either a hydrophobic interior micelle or a hydrophilic exterior micelle, the QDs can be ... which will spontaneously form micellular structures at its critical micelle concentration (CMC). The critical micelle ...
... micelles} }} is number concentration of micelles (number of micelles per unit volume), and N A {\displaystyle N_{\mathrm {A ... A dispersion resulting from emulsion polymerization is often called a latex (especially if derived from a synthetic rubber) or ... Excess surfactant creates micelles in the water. Small amounts of monomer diffuse through the water to the micelle. A water- ... Monomer in the micelle quickly polymerizes and the growing chain terminates. At this point the monomer-swollen micelle has ...
An alternative method using micelles was found, with green characteristics. Micelles generally facilitate reactions thanks to ... which resulted in higher yield of β-Halostyrenes. They found that using the microwave irradiation could synthesize (E)-β- ... The trend in the yield of the resulting halide is primary > secondary > tertiary. Chowdhury and Roy noted several drawbacks of ... β-unsaturated carboxylic acids result in low yield. Regarding reactions using α, β-unsaturated carboxylic acids, Kuang et al. ...
... by transient adsorption of micelles at the water-oil interface, and bulk reaction, whereby the surfactant micelles capture ... Solubilization is distinct from dissolution because the resulting fluid is a colloidal dispersion involving an association ... Solublization may occur in a system consisting of a solvent, an association colloid (a colloid that forms micelles), and at ... Literature distinguishes two major mechanisms of solubilization process of oil by surfactant micelles, affecting the kinetics ...
... as removal of the CYP79A1 gene from the Sorghum bicolor genome results in plants lacking dhurrin content. This strain could ... vitro biosynthesis of dhurrin has been constructed in both microsomes recovered from Sorghum bicolor seedlings and in micelles ... are much more likely to eat an amount that would contain a lethal dosage of dhurrin for their respective species and can result ...
There are several models that account for the special conformation of casein in the micelles. One of them proposes that the ... This method is the result of a modification to the one described by S.S. Twining (1984). The main modification was substituting ... Milk-clotting proteases act on the soluble portion, κ-casein, thus originating an unstable micellar state that results in clot ... Holt, C. (1992). "Structure and Stability of Bovine Casein Micelles". In Anfinsen, C.B.; Richards, Frederic M.; Edsall, John T ...
... for the interior region of reverse micelles and determined how water structure and mobility varied with reverse micelle water ... predicting that chromophore-surfactant interactions can lead to dramatically different results for solutes that repelled by and ... Although quite simple, this model helped to explain many observed trends in water and solute dynamics in reverse micelles. Its ... Faeder, J.; Ladanyi, B. M. (2000). "Molecular Dynamics Simulations of the Interior of Aqueous Reverse Micelles". The Journal of ...
This results in a type of surfactant that usually is classified as amphipathic. Lecithin is sold as a food additive and dietary ... In aqueous solution, its phospholipids can form either liposomes, bilayer sheets, micelles, or lamellar structures, depending ...
As the micelles form, the micelle diameter actually shrinks creating a "reel in" effect. The general structure of these ... The resulting interfacial copolymer helps to stabilize the dispersed phase due to the hydrogen-bonding effects of ... Micelles of the gradient copolymer can form when the gradient copolymer concentration is too high in a block copolymer solution ... The resulting change in composition throughout the polymerization creates an inconsistent gradient along the polymer. Forced ...
Quantum confinement results when the electrons in a material are confined to a very small volume. Quantum confinement is size ... Examples of this ordering are layered alternating sheets of solution and surfactant, micelles, or even a hexagonal arrangement ... However, results from recent studies challenge this model. Using NMR, quantum dots have been shown to be nonstoichiometric ... The addition of surfactants to solutions often results in a phase change in the solution leading to a liquid crystallinity. A ...
The complex specifically targeted human prostate cancer cells in vitro, and these results suggest that SIPPs may have a role in ... In a recent study, multifunctional SIPP micelles were synthesized and conjugated to a monoclonal antibody against prostate- ...
This results in a type of surfactant that is usually classified as amphipathic. Commercial egg lecithin, specified in the ... In aqueous solution, its phospholipids can form either liposomes, bilayer sheets, micelles, or lamellar structures, depending ...
... this biophysical interaction may result in the formation of micelles, liposomes, or lipid bilayers. Other aggregations are also ... Micelles and bilayers form in the polar medium by a process known as the hydrophobic effect. When dissolving a lipophilic or ...
As a result, simple, easy to produce and more environmentally friendly surfactants are used more widely. Rosen MJ (September ... Soluble surfactants are also capable of forming micelles and other aggregate structures in solution, leading to a stabilizing ... In solutions this behavior is known as wetting, and it occurs as a result of surfactants adsorbing to the air/water interface. ... The thermodynamic explanation for demulsification is the gain in Gibbs Free Energy resulting from lowering the total area of ...
As a result, the concentration of bile acids/salts in the small intestine is high enough to form micelles and solubilize lipids ... They serve as micelle-forming surfactants, which encapsulate nutrients, facilitating their absorption. These micelles are ... These result in the junction between the first two steroid rings (A and B) being altered, making the molecule bent; in this ... Bile acid-containing micelles aid lipases to digest lipids and bring them near the intestinal brush border membrane, which ...
A micelle - the lipophilic ends of the surfactant molecules dissolve in the oil, while the hydrophilic charged ends remain ... A molecule may be polar either as a result of polar bonds due to differences in electronegativity as described above, or as a ... A polar molecule has a net dipole as a result of the opposing charges (i.e. having partial positive and partial negative ... The dipoles do not cancel out resulting in a net dipole. Due to the polar nature of the water molecule itself, polar molecules ...
Food fat is dispersed by the action of bile into smaller units called micelles. The breaking down into micelles creates a much ... This initially results in the production of chyme which when fully broken down in the small intestine is absorbed as chyle into ... This results in a much larger surface area for the action of digestive enzymes. The teeth are named after their particular ... Mastication of the food with the help of saliva and mucus results in the formation of a soft bolus which can then be swallowed ...
The milling of cereals results in considerable loss (up to 60%) of vitamin B2, so white flour is enriched in some countries ... The beaker prepared at left holds a detergent in water, forming micelles that will show the passage of a visible laser beam. ... A deficiency of riboflavin can be primary - poor vitamin sources in one's daily diet - or secondary, which may be a result of ... In other animals, riboflavin deficiency results in lack of growth,[28] failure to thrive, and eventual death. Experimental ...
Unintended resultsEdit. This article needs additional citations for verification. Please help improve this article by adding ... Corbett, J. F. Hair Colorants: Chemistry and Toxicology; Micelle Press: Dorset, U.K., 1998; Thompson, R. H. "Naturally ... As the result, they cannot color hair to a lighter shade than it was before dyeing and are less damaging to hair than their ... Dipping or tip dyeing, similar to balayage in that the color is painted directly on the hair (This results in a more solid ...
Due to the lack of a strong secondary or tertiary structure as a result of the proline residues, casein micelles are not heat ... At a pH of 6.5 the casein micelles repulse each other due to the electronegativity of the outer layer of the micelle.[8] During ... its structure also assists in the reactivity of the micelle.[10] The formation of casein molecules into the micelle is very ... having a lower density than the core of the micelle. Casein micelles are rather porous structures, ranging in the size of 50- ...
Surfrider Foundation released preliminary results of their study "State of the Beach" in which they found that Corexit appears ... the dispersant transforms the oil containing the PAHs into small micelles that can penetrate through the interstitial space of ...
... of the micelle. The compounds that coat a micelle are typically amphiphilic in nature, meaning that micelles may be stable ... The water-solubility of the oxygen groups is the result of hydrogen bonding. Hydrogen bonding decreases with increasing ... Micelles, HLB. Surface rheology, adsorption. Langmuir trough, ellipsometry, Xray, surface rheology. Films. Frankel's law. ... Schematic diagram of a micelle of oil in aqueous suspension, such as might occur in an emulsion of oil in water. In this ...
Paulsson JF, Westermark GT (July 2005). "Aberrant processing of human proislet amyloid polypeptide results in increased amyloid ... "Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy". Biochemistry. 47 (48): ...
Cross-linking hydrophobic and hydrophilic polymers results in formation of micelle-like structures that can protectively assist ... resulting in rapid release of drugs entrapped in its matrix. A combination of PAAc with another polymer that is less sensitive ... often a hydrolysis reaction resulting in cleavage of bonds and release of drug as the matrix breaks down into biodegradable ...
Various approaches have been developed to achieve this goal, with many of them producing significantly better results over oil- ... which facilitates emulsification and micelle formation required for absorption of lipophilic substances.[39] Food intake (and ... "supplementation with CoQ10 resulted in a pooled mean net change of 3.67% (95% CI: 1.60%, 5.75%) in the ejection fraction, and - ...
The cell membrane of nearly all organisms is primarily made up of a phospholipid bilayer, a micelle of hydrophobic fatty acid ... It is often wrongly assumed that neutralization should result in a solution with pH 7.0, which is only the case with similar ... Neutralization with a base weaker than the acid results in a weakly acidic salt. An example is the weakly acidic ammonium ...
The third mechanism responsible for the translocation is based on the formation of the inverted micelles. Inverted micelles are ... It is probable that the results indicate that several CPP mechanisms are in competition and that several pathways contribute to ... thus generating the formation of an inverted micelle inside of the lipid bilayer. The structure of the inverted micelles ... Results on antiviral activity with PNA targeting HIV-1 have also been reported through disulfide linkage with TAT.[43] CPP-PMO ...
Meta-analyses have borne out conflicting results on the mortality benefit.[7] However analyses that exclude trials of short ... helps regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles ...
The minimized number of boundary molecules results in a minimal surface area.[2] As a result of surface area minimization, a ... Decrease surface tension until certain critical concentration, and no effect afterwards: surfactants that form micelles ... Since any curvature in the surface shape results in greater area, a higher energy will also result. Consequently, the surface ... Due to the cohesive forces a molecule is pulled equally in every direction by neighboring liquid molecules, resulting in a net ...
As a result, some fat cannot be absorbed from the gut and is excreted in the feces instead of being metabolically digested and ... which reduces micelle formation, and small intestinal disease producing malabsorption. Various other causes include certain ... As a result, the product was reformulated before general release to a hydrogenated form that is not liquid at physiologic ... The U.S. Food and Drug Administration warning indicated excessive consumption of Olestra could result in "loose stools"; ...
The critical micelle concentration for deoxycholic acid is approximately 2.4-4 mM.[4] ... in gut microbiota is increased resulting in greater conversion of the non-genotoxic primary bile acid, cholic acid, to ... Secondary bile acids increase intracellular production of reactive oxygen and reactive nitrogen species resulting in increased ...
Micelles, HLB. Surface rheology, adsorption. Langmuir trough, ellipsometry, Xray, surface rheology. Films. Frankel's law. ... Assembling several bubbles results in foam. When light shines onto a bubble it appears to change colour. Unlike those seen in a ... Each colour is the result of varying thicknesses of soap bubble film. Tom Noddy (who featured in the second episode of Marcus ... However the soap film is as thin as the visible light wavelength, resulting in interferences. This creates iridescence which, ...
... can result in a lack of viscosity resulting in a cheese spread that has more liquid than solid properties after passing through ... Casein micelles have a diameter ranging from 15-20 nanometers and are composed of flexible aggregates alpha, beta, and kappa- ... All of the negative charges causes the casein micelles to initially repel each other and provides stability to the matrix by ... When the group of casein micelles are exposed to heat and shearing forces, kappa-casein is cleaved causing the displacement of ...
This effect results from the fact that the driving force for mixing is usually entropy, not interaction energy. In other words ... polymeric micelles, and other materials. ... Nitrogen is generally used for this purpose, resulting in a ... Furthermore, the asphalt concrete road surface will suffer damage as a result of the diesel fuel dissolving the asphaltenes ... Dynamic mechanical analysis or DMA measures this complex modulus by oscillating the load and measuring the resulting strain as ...
This results in shorter sintering times compared to solid state sintering. A material's strength is dependent on its ... Molecular crystals, liquid crystals, colloids, micelles, emulsions, phase-separated polymers, thin films and self-assembled ... Differential stresses that develop as a result of non-uniform drying shrinkage are directly related to the rate at which the ... Thus, the pores in the object may close up, resulting in a denser product of significantly greater strength and fracture ...
This is a disadvantage because the preference of the dye to bind to these amino acids can result in a varied response of the ... When SDS concentrations are below critical micelle concentration (known as CMC, 0.00333%W/V to 0.0667%) in a Coomassie dye ... Although these modifications result in a less sensitive assay, a modified method becomes sensitive to detergents that can ... If nucleic acids are present in the sample, they would also absorb light at 280 nm, skewing the results further. By using the ...
One unfortunate result of the dispute was professional divisiveness among the mining engineering community for a generation. ... The adsorbed ligands can form micelles around the particles and form small-particle colloids improving stability and phase ... This results in a relatively low interfacial area and a low probability of particle-bubble contact.[24] Consequently, several ... resulting in higher energy surfaces to form attractions with adsorbates. The air bubbles must selectively adhere to the desired ...
... and bile salts form mixed micelles, in the watery duodenal contents (see diagrams on the right). The contents of these micelles ... This results in the complete combustion of the acetyl-CoA to CO2 and water. The energy released in this process is captured in ... The resulting molecule is prostaglandin G2 which is converted by the hydroperoxidase component of the enzyme complex into ... Once a 16:0 carbon fatty acid has been formed, it can undergo a number of modifications, resulting in desaturation and/or ...
When M is Li, the result is lithium soap (e.g., lithium stearate), which is used in high-performance greases.[3] ... Structure of a micelle, a cell-like structure formed by the aggregation of soap subunits (such as sodium stearate): The ... Each species offers quite different fatty acid content, resulting in soaps of distinct feel. The seed oils give softer but ... The insoluble oil/fat molecules become associated inside micelles, tiny spheres formed from soap molecules with polar ...
... may be a preferable meat tenderizer to papain due to the resulting texture of meat produced. While papain can ... The enzymes thus destabilize κ-casein micelles and encourage clumping of hydrophobic protein residues, causing milk to curdle. ... to eliminate any resulting misfolded or denatured proteins.[9] ...
Ordinarily, the micelles in the duodenum have a diameter around 14-33 μm.[citation needed] ... The blockage of bile might cause a build up of bilirubin in the bloodstream which can result in jaundice. There are several ... The dispersion of food fat into micelles provides a greatly increased surface area for the action of the enzyme pancreatic ... In some instances of biliary obstruction, the bile may become infected by bacteria resulting in ascending cholangitis. ...
... this has resulted in a revision in the classification of placentals.[7] There are now thought to be three major subdivisions or ... Micelle; Spaulding, Paul M.; Velazco, Marcelo; Weksler, John r.; Wible, Andrea L.; Cirranello, A. L. (8 February 2013). "The ...
Casein micelles are attracted to the newly exposed fat surfaces. Nearly one-third of the micelles in the milk end up ... As a result of this treatment, all the pathogenic bacteria within the milk are destroyed, unlike when the milk is just ... However, there are two recent models of the casein micelle that refute the distinct micellular structures within the micelle. ... Each casein micelle is roughly spherical and about a tenth of a micrometer across. There are four different types of casein ...
Excess unreacted lye in the soap results in a very high pH and can burn or irritate skin, whereas not enough lye leaves the ... Structure of a micelle, a cell-like structure formed by the aggregation of soap subunits (such as sodium stearate): The ... Each species offers quite different fatty acid content and hence, results in soaps of distinct feel. The seed oils give softer ... The insoluble oil/fat molecules become associated inside micelles, tiny spheres formed from soap molecules with polar ...
In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to ... Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing ... Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing† ... Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug-siRNA ...
Purpose Worm-like and spherical micelles are both prepared here from the same amphiphilic diblock copolymer, poly(ethylene ... Results. The fission process exploits the finding that the PCL cores are fluid, rather than glassy or crystalline, and core- ... shows that the worm-like micelles load and solubilize twice as much drug as spherical micelles. In cytotoxicity tests that ... Thermally sensitive micelles self-assembled from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide-c o- ...
Results. The amount of coumarin in the brain after intranasal administration was significantly higher than that after ... biodistribution brain tumors cell penetrating peptide intranasal brain delivery micelles Takanori Kanazawa and Hiroyuki Taki ... Yokoyama M, Opanasopit P, Okano T, Kawano K, Maitani Y. Polymer design and incorporation methods for polymeric micelle carrier ... We have demonstrated that utilization of nano-sized micelles modified with Tat can facilitate direct intranasal brain delivery. ...
These results demonstrate that the hydrophobicity of the drug influences its ability to be encapsulated within the micelle, but ... uncrosslinked drug loaded micelles, or crosslinked, drug loaded micelles dissolved in 150 mM NaCl. Daunorubicin micelles were ... The addition of iron chloride to the micelle did not affect the drug and did not result in generation of polymer-drug ... To test stability of the crosslinked micelle, the in vitro stability of the micelle below the CMC was determined using a ...
Formation of drug-loaded micelles with these triblock copolymers typically represents a 70-90% efficient process, and results ... Epothilone D from the NHOH micelle formulation demonstrated a of 42.7 μg/mL at the 1 minute time point and an of 18.9 h. μg/mL ... Epothilone D from the Cys micelle formulation demonstrated a of 34 μg/mL at the 1-minute time point and an of 10.6 h. μg/mL. ... General Method for Formulation of Epothilone D Loaded Micelles (Hydroxamate). Formulation of epothilone-loaded micelles was ...
The effect of pH on iron-containing complex coacervate core micelles [Fe(III)-C3Ms] is investigated in this paper. The Fe(III)- ... Effect of pH on complex coacervate core micelles from Fe(III)-based coordination polymer. Wang Junyou, Junyou; Keizer, A. de; ... Research & Results. *Library *Health and nutrition *Climate and water *Food production *Biobased economy ...
Nevertheless, we prepared micelles using the resulting polymer and demonstrated that they could be loaded with pyrene.26 ... Thin to thick wormlike micelles as well as fibrous micelles can be provided depending on the chain used. The micelles have ... Micelle formulation study. Polymer micelles were prepared by dissolving poly(arb)-Rx (5 mg) in DMSO (0.5 mL), followed by the ... 5 shows the results of DLS analysis of the prepared micelles in water. Clearly, for both the C3 and C8 samples, the diameters ...
Human hepatic carcinoma vascular endothelial cells (T3A) were cultured with the resulting micelles to assess the micelle uptake ... The particle size distribution of non-targeting micelles mPEG-PCL-γ-Fe2O3 and targeting micelles cRGD-PEG-b-PCL-γ-Fe2O3. The ... Since the surface area of the micelles increases by molecular exclusion of cRGD on the micelle surface, the micelle core ... Keywords: micelles, PEG-PCL, cRGD, γ-Fe2O3, MRI Background. Cancer is a leading cause of death worldwide, resulting in 8.8 ...
It has been suggested that polymeric micelle nanoparticle drug carriers preferentially target tumor tissues, resulting in ... RESULTS. Twenty-one patients were entered into this study between August 2001 and October 2002, and all were eligible for ... Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery. Adv Drug Deliv Rev, 54: 169-90, 2002. ... Results: All of the patients were evaluable for toxicity and response. Acute hypersensitivity reactions were not observed. ...
Representative Results. 图3. 苯基缩水甘油醚的基于MPEG大分子引发剂阴离子聚合的插图制作MPEG- 期 B - (PheGE)15 制备嵌段共聚物胶束的阿霉素的装载示意图使用萘钾说明了羟基的mPEG的去质子化。作为自由基阴离子 ... Kwon, G., et al. Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate). Langmuir. 9 ... Nakanishi, T., et al. Development of the polymer micelle carrier system for doxorubicin.
As far as we know, the present study is the first time to demonstrate the potency of both fisetin and fisetin micelles inducing ... Multiple lines of evidence indicated that fisetin and fisetin micelles induce apoptosis in ovarian cancer cells in a dose- ... In addition, the efficacy of fisetin and fisetin-micelles in vivo was determined by using immunocompromised mice. Apoptosis was ... Further studies will be needed to validate the therapeutic potential of fisetin and fisetin micelles in ovarian cancer ...
Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces. Access & Citations. * ... Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces - Docwire News Doc Wire ...
Thus, there is an increasing interest in new micelle-forming, drug-solubilizing molecules that can offer im.. ... The results for the conventional surfactant Brij-35 are presented for the purpose of comparison. The results are averaged over ... From crystal to micelle,. ∆μ0cr/sol/kT. From water to micelle,. ∆μ0cr/sol/kT. ... micelles energetically favourable, resulting in the measured strong increase of their aqueous solubility. Furthermore, the ...
Results for 2D micelles. Publications & Outputs. *. Formation of two-dimensional micelles on graphene: a multi-scale ... Surface Functionalization of Graphene via the Controlled Assembly of 2D Micelles. Robinson, B. J., Kolosov, O. V., Bailey, S. W ...
Publications of Results: Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin ... Experimental: Curcumin micelles 500 mg curcumin incorporated into liquid micelles. Dietary Supplement: curcumin 500 mg curcumin ... Oral Bioavailability of Curcumin From Micronized Powder and Liquid Micelles in Healthy Young Women and Men. The safety and ... Study record managers: refer to the Data Element Definitions if submitting registration or results information. ...
Currently viewing only significant results (P-value , 0.001). Show all available results. ... A 40% sequence identity filter is applied before the structure alignments are calculated, so most results show low similarity. ...
... and Conductance of Gly15-Gramicidin a Incorporated Into Sds Micelles and Pc/Pg Vesicles. ... Currently viewing only significant results (P-value , 0.001). Show all available results. ... A 40% sequence identity filter is applied before the structure alignments are calculated, so most results show low similarity. ...
Search Results. 1. Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin ... Number of results to display per page 50 per page *20 per page ... micelles Remove constraint Subject: micelles Start Over ... micelles; palmitates; aqueous solutions; hydroxyl radicals; intravenous injection; moieties; neoplasms; hydrogen peroxide; ... micelles; nanocarriers; neoplasm cells; platinum; polyethylene glycol. Abstract:. ... The intrinsic or acquired cisplatin ...
Results showed that SSM in conc. of 40 mg/mL shows very low cytotoxicity at the end of 24, 48 and 72 h. The DNA damage caused ... The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM ... The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using ... 2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and ...
Keywords: micelles; antigens; amphiphilic copolymers; peptide amphiphiles micelles; antigens; amphiphilic copolymers; peptide ... Micelle-Based Adjuvants for Subunit Vaccine Delivery. Thomas Trimaille 1,* and Bernard Verrier 2. ... Trimaille, T.; Verrier, B. Micelle-Based Adjuvants for Subunit Vaccine Delivery. Vaccines 2015, 3, 803-813. ... "Micelle-Based Adjuvants for Subunit Vaccine Delivery." Vaccines 3, no. 4: 803-813. ...
Each of the plurality of cylindrical micelles may be loaded with a therapeutic agent. ... and a plurality of entangled cylindrical micelles disposed on the expandable framework. ... solidification of the cylindrical micelles 50 may be achieved by rapid evaporation of one or more solvent components resulting ... The cylindrical micelles 50 are not illustrated in FIG. 1. for the sake of clarity). Cylindrical micelles are a class of self- ...
Results: The cellular study showed that Val-PMs/Phe-PMs had a high PepT1 affinity, resulting in a higher drug uptake and ... To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the transport efficiency ... Methods: Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) ... Conclusion: PepT-1-mediated micelles, using PepT1 as a target on intestinal epithelium, have unique functions with intestine ...
Conclusions: The results demonstrate that micelle formulated ICG can be visualized in the retinal vasculature and laser-induced ... Results: In vivo imaging before dye application showed ill-defined retinal lesions at day 7. Immediately following intravenous ... In vivo imaging of a new indocyanine green micelle formulation in an animal model ... In vivo imaging of a new indocyanine green micelle formulation in an animal model ...
... and changes in isometric tension were recorded.Results: Cinnamaldehyde induced concentration-dependent but endothelium- ... Cinnamaldehyde-loaded micelles also inhibited contractions induced by 40 mM KCl Ca2+ reintroduction or Bay K8644. Poly( ... Cinnamaldehyde-loaded control micelles induced complete, partly endothelium-dependent relaxations sensitive to catalase and ... micelles possess vasodilator properties, but that the mechanism underlying the relaxation that they cause differs from that of ...
CA2920328)This nucleic acid-encapsulating polymer micelle complex is characterized in being formed of: a block copolymer ... Retrieval result of J-STORE Back to the list Contact Information for " Nucleic acid-encapsulating polymer micelle complex and ... Nucleic acid-encapsulating polymer micelle complex and method for producing same Abstract. (CA2920328). This nucleic acid- ... Nucleic acid-encapsulating polymer micelle complex and method for producing same Foreign code. F170009169. ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T ... Results: 5. 10. 20. 40. 60. 80. 100. Update. Now showing items 1-1 of 1 ...
Results and Discussion. The path of the chemical reaction between RA, biotin and pullulan is shown in fig. 1. PRB micelle was ... These results showed that DOX loaded in biotin-targeted micelles was more cytotoxic than free DOX and DOXloaded non-targeted ... 7a shows the results of MCF-7 cell viability by MTT assay in the presence of free DOX, DOX-loaded targeted micelles and DOX- ... CMC of PRB micelles. To determine the CMC value of the PRB micelles, pyrene is used as a hydrophobic fluorescent probe in 﫿 ...
The results show that upon rapid change in salt concentration, "worm-like" micelles are formed by the fusion of globular and ... Figure 2. Fit results deduced from the time-resolved SAXS data. a) Time dependence for the aspect ratio of SDS micelles, in 0.5 ... The above findings suggest that individual micelles undergo successive fusion events resulting in elongated structures. Because ... Figure 3. Schematic illustration of the transformation of spherical/ellipsoidal micelles to worm-like micelles at higher salt ...
RESULTS. Preparation of CSO-SA and PPT-CSO-SA. The CSO-SA was prepared by coupling reaction between amine groups of CSO and ... In vitro antitumor activities of micelles. In vitro assay of micelles, we used CSO-SA (25% the substitute degree of amino ... the majority of drugs were located in the cores of micelles. The micelles could greatly improve the water solubility of ... Zeta potentials of micelles decreased in comparison with CSO-SA when PPT was loaded to CSO-SA. With the increase of the PPT- ...
I got some reasonable results. Unexpectedly, I had to set nres. Subst.doc led me to believe. it would automatically be set ... The px,py,pz time series have the average position of all P atoms, which is probably close to the COM for an intact micelle. ... Although there are no errors, the resulting time series is smaller than expected; all values are less than 1. I must have done ... stream toppar.str read psf card name /export/lustre_1/mallsopp/dpc/radius/setup/micelle-tmp-sim1.psf OPEN UNIT 1 READ CARD ...
  • To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. (hindawi.com)
  • Polymer micelles offer a promising approach to achieving these goals due to their inherent ability to overcome multiple biological barriers, such as avoidance of the reticuloendothelial system (RES) [ 2 ]. (hindawi.com)
  • Polymer micelles have received much attention over the past thirty years as drug delivery vehicle [ 5 - 11 ]. (hindawi.com)
  • Many different drug delivery technologies, including liposomes, degradable polyester particles, and polymer micelles, have been investigated both preclinically and clinically, but few have achieved FDA approval [ 23 ]. (hindawi.com)
  • 11-13 Inspired by natural compounds, polyphenol derivatives loaded within synthetic polymer micelles were prepared for anti-cancer reagent 14 and dermatitis treatment. (rsc.org)
  • The present experiments were designed to compare the acute relaxing properties of cinnamaldehyde with those of self-assembling polymer micelles either loaded with cinnamaldehyde or consisting of a polymeric prodrug [poly(cinnamaldehyde)] that incorporates the compound in its backbone. (dovepress.com)
  • 8-10 Numerous efforts have been paid to study the micelle formulation ability and the morphology by the use of various kinds of amphiphilic block copolymers. (rsc.org)
  • In this project, we conducted the synthesis of heterobifunctional PEO/PBLA block-copolymers as well as the synthesis and chariacterzation of the resulting polymeric micelles. (nii.ac.jp)
  • Dynamic light scattering measurements revealed a formation of micelles with relatively narrow distribution from block copolymers with considerably high substitution degree of side chain. (nii.ac.jp)
  • Of interest, in the case of block copolymers of PEG with poly (L-lysine) substituted with hydrocynnamic acid (HCA), secondary structure of poly (L-lysine) segments changed from random to beta-sheet upon micellization, indicating a close relationship between micelle formation and secondary structure of poly (amino acid) segments forming the core. (nii.ac.jp)
  • Publications] S.Cammas: 'Design of functional polymeric micelles as site-specific drug vehicles based on poly (α-hydroxy ethylene oxide-co-β-benzyl L-aspartate) block copolymers' Materials Science & Engineering C. (in press). (nii.ac.jp)
  • Lastly, micelles result from electrostatic interaction between nucleic acids and copolymers. (wikipedia.org)
  • 3. The worm-like micelle of claim 1, wherein all of the super-amphiphilic molecules comprising the micelle are block copolymers. (freepatentsonline.com)
  • 5. The worm-like micelle of claim 4, wherein increasing molecular weight of the copolymers increases both core diameter of the worm-like micelle and its stiffness in terms of persistence length. (freepatentsonline.com)
  • Polymeric micelles, which are commonly formed by amphiphilic block copolymers, demonstrate excellent potential in the field of DDS. (omicsonline.org)
  • Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. (uzh.ch)
  • Formation of Complex Micelles with Double-Responsive Channels from Self-Assembly of Two Diblock Copolymers. (docme.ru)
  • Angewandte Chemie Channels in Micelles DOI: 10.1002/ange.200600172 Formation of Complex Micelles with DoubleResponsive Channels from Self-Assembly of Two Diblock Copolymers** Guiying Li, Linqi Shi,* Rujiang Ma, Yingli An, and Nan Huang The establishment of an effective method to prepare desirable nanostructures and to eventually convert them into designed architectures is of increasing interest in nanotechnology, chemistry, and biology. (docme.ru)
  • 11-15] For example, Jiang and co-workers reported core-stabilized polymeric micelles with a mixed shell made from two incompatible copolymers. (docme.ru)
  • 16-19] We present herein a simple and effective method to prepare complex micelles with tunable channels from the self-assembly of two diblock copolymers, namely, poly(tertbutyl acrylate)-b-poly(N-isopropylacrylamide) (PtBA-bPNIPAM) and poly(tert-butyl acrylate)-b-poly(4-vinylpyridine) (PtBA-b-P4VP). (docme.ru)
  • Thus, there is an increasing interest in new micelle-forming, drug-solubilizing molecules that can offer improved effectiveness and safety. (ijpsonline.com)
  • However, there is an increasing interest in finding new micelle-forming, drugsolubilizing molecules that offer improved drug-loading capacity, lower toxicity and greater drug stability [ 9 - 11 ]. (ijpsonline.com)
  • Promising results were obtained also with hydrophobically-modified polysaccharides: amphiphilic molecules formed by conjugation of a polysaccharide (e.g. pullulan, cellulose, dextran, heparin) with a hydrophobic moiety (e.g. fatty acids, bile acids, cholesterol, polylactides) [ 15 ]. (ijpsonline.com)
  • Producing micelles from pullulan requires conjugation with hydrophobic molecules to gain amphiphilic nature. (ijpsonline.com)
  • In this work, the surface activities and pH-induced self-assembling behaviors of the semi-synthetic CLA molecules into micelles or vesicles. (ebscohost.com)
  • Notably, this cross-linking method provides the possibility for conjugation of functional molecules either by using the thiol moieties still present after NCL or by simply adjusting the molar ratio between the polymers (resulting in excess cysteine or thioester moieties) during micelle formation. (wur.nl)
  • To facilitate the introduction of targeting molecules onto micelle formulations, a naturally occurring surfactant protein oleosin was used to stabilize superparamagnetic iron oxide clusters. (upenn.edu)
  • Before silica-shelling, they coated the quantum dots with detergent micelles, which enable the incorporation of other hydrophobic molecules, such as lipid-soluble photosensitizers, and hydrophobic oxidizing and contrast agents. (photonics.com)
  • and wherein at least one of said super-amphiphilic molecules is a hydrophilic block copolymer, the weight fraction (w) of which, relative to total copolymer molecular weight, directs assembly of the amphiphilic molecules into the worm-like micelle of up to one or more microns in length, and determines its stability, flexibility and convective responsiveness. (freepatentsonline.com)
  • 2. The worm-like micelle of claim 1, wherein the one or more super-amphiphilic molecules of the micelle comprise at least one di-block copolymer. (freepatentsonline.com)
  • 6. The worm-like micelle of claim 4, wherein at least a portion of the one or more super-amphiphilic molecules of the micelle are chemically cross-linked. (freepatentsonline.com)
  • As a model system, we used amphiphilic polymer molecules carrying both water-repellent and water-compatible blocks, which spontaneously self-organize into so-called "micelles" when dispersed in water. (uio.no)
  • We also discovered a new mechanism how molecules move between different micelles. (uio.no)
  • Micelles are lipid molecules that arrange themselves in a spherical form in aqueous solutions. (wikibooks.org)
  • Conversely, for membrane protein complexes in micelles, the transition into the gas phase usually leads to the disruption of interactions, particularly between cytoplasmic and membrane subunits, and a mass spectrum dominated by large aggregates of detergent molecules. (sciencemag.org)
  • The results clearly show that the enzyme molecules preferentially adsorb on the lateral surfaces of the single crystal but not on the chain-folded surfaces. (jove.com)
  • In the appropriate medium, the ionizable regions of the micelles interacted with oppositely charged molecules, thus forming polyion complex micelles (PIC micelles) with a core-shell structure [ 7 , 8 ]. (omicsonline.org)
  • We demonstrate that the co-delivery of these two agents with our micellar system results in a synergistic tumor cell killing of cervical and breast cancer cell lines in vitro . (rsc.org)
  • These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes. (hindawi.com)
  • Often, a large percentage of cytotoxic drug administered to the patient does not reach the tumor environment but rather is distributed throughout the body, resulting in the many toxic effects associated with chemotherapy and a narrowing of the drug's therapeutic window. (hindawi.com)
  • The EPR effect is a consequence of the disorganized nature of the tumor vasculature, which results in increased permeability of polymer therapeutics and drug retention at the tumor site. (hindawi.com)
  • γ-Fe 2 O 3 -loaded PEG-PCL micelles not only possess ultra-small size and high superparamagnetic sensitivity, also can be actively targeted to carcinoma vascular endothelial cells by tumor-targeted cRGD. (medsci.org)
  • Histological analysis, terminal deoxynucleotidyltransferase-mediated nick-end labeling assay, western blot, immunohistochemical detection and microvessel density detection demonstrated that fisetin and fisetin micelles induced increased tumor apoptosis, proliferation suppression and antiangiogenesis activities. (biomedcentral.com)
  • In current study, we detected the effect of fisetin and fisetin-micelles on ovarian cancer cell line growth, the relative apoptosis pathway and the anti-tumor effect in xenograft mice. (biomedcentral.com)
  • Tumor accumulation ratios to normal tissue (muscle) at 24 hours for polymeric micelles (tumor/muscle ratio=40) showed an order of magnitude increase in comparison to free adriamycin (tumor/muscle ratio=1.5). (nii.ac.jp)
  • An increase in the tumor accumulation ratio to the heart was also significant for the micelle-forming conjugate, suggesting a low incidence of cardiac toxicity in the conjugate system. (nii.ac.jp)
  • In vitro cytotoxicity test showed that the micelles had a dose-dependent toxicity for HeLa cells, indicating a great potential for controlled release of 6-mercaptopurine in tumor cells. (scirp.org)
  • Therefore, if we chose the dimer that two monomer units were joined by a disulfide bond, it would be able to remain stable in bloodstream, and become easy to cleavage once the micelle had entered into tumor cells, and the controlled release of drug might be achieved. (scirp.org)
  • Despite current advances in imaging technologies and treatment planning strategies, a major limitation persists in accurately delineating tumor from normal tissue resulting in radiation-induced damage to healthy structures. (upenn.edu)
  • Unfortunately, many probes enable preferential accumulation in tumor sites through the EPR effect, which may not result in the desired imaging effects. (biomedcentral.com)
  • Here, we highlight key aspects of the design of polymeric micelles as therapeutic delivery systems with a review of their clinical applications in several non-brain tumor cancer types. (frontiersin.org)
  • Nile red-GCP micelles lead to higher levels of fluorescence in tumor. (nsti.org)
  • The two most recent models are a solution NMR structure of PLN in detergent micelles (dodecylphosphocholine, DPC) with an unusual bellflower topology ( 11 ), and a low-resolution pinwheel model derived from fluorescence anisotropy data ( 12 ). (pnas.org)
  • Our results suggest that protein lipid complexes form via contacts between proteins and mixed lipid/detergent micelles. (diva-portal.org)
  • For soluble proteins, these complexes arise from nonspecific contacts between the protein and detergent/lipid micelles in the electrospray droplet. (diva-portal.org)
  • Here, however, we show that by maintaining detergent micelles in solutions, well above the critical micelle concentration (CMC), it is possible to protect interactions between cytoplasmic and transmembrane subunits and, through gas-phase activation, release intact membrane complexes. (sciencemag.org)
  • There has been a renewal of interest in interactions of membrane proteins with detergents and lipids, sparked both by recent results that illuminate the structural details of these interactions and also by the realization that some experimental membrane protein structures are distorted by detergent-protein interactions. (mendeley.com)
  • NMR measurements revealed significant differences in DAGK-detergent interactions involving LMPC micelles versus micelles composed of dodecylphosphocholine. (mendeley.com)
  • These results highlight the fact that some integral membrane proteins can maintain native-like properties in lipid-free detergent micelles and also suggest that C(14)-based detergents may be worthy of more widespread use in studies of membrane proteins. (mendeley.com)
  • The unusual properties are suggested to result from interactions of the positively charged head-group of the detergent with the tetrapyrrole. (uni-muenchen.de)
  • Biotin and retinoic acid grafted pullulan conjugate was synthesized using carbodiimide activation ester bond formation strategy for biotin targeted delivery of doxorubicin in breast cancer chemotherapy using micelle formulation. (ijpsonline.com)
  • Doxorubicin-loaded micelles were prepared using the direct dissolution method. (ijpsonline.com)
  • The cytotoxicity of doxorubicin-loaded micelles was studied in MCF-7 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. (ijpsonline.com)
  • The results of in vitro cell culture cytotoxicity assay showed that the doxorubicin-loaded biotin grafted retinoic acid-pullulan micelles were more cytotoxic in comparison to the non-targeted pullulan and free doxorubicin. (ijpsonline.com)
  • Publications] G.Kwon: 'Block copolymer micelles for drug delivery : Loading and release of doxorubicin' J.Controlled Release. (nii.ac.jp)
  • Results of the comet (DNA degradation) assay presented in a previous publication [ 1 ] show that Doxorubicin (Dox) released from Pluronic micelles eventually binds to the DNA and causes it to fragment. (biomedcentral.com)
  • Lysosensor Green is hydrophobic, which indicates that in aqueous Pluronic solutions it will partition to the poly (propylene oxide) core of the Pluronic micelles, similar to the manner in which Doxorubicin and Ruboxyl partition to the core [ 4 ]. (biomedcentral.com)
  • Combination therapy with EGCG and doxorubicin in the micelle core could protect the cardiomyocytes from DOX-mediated cardiotoxicity. (greenmedinfo.com)
  • Green Tea Catechin-Based Complex Micelles Combined with Doxorubicin to Overcome Cardiotoxicity and Multidrug Resistance. (greenmedinfo.com)
  • In this study, a novel green tea catechin-based polyion complex (PIC) micelle loaded with doxorubicin (DOX) and (-)-Epigallocatechin-3-O-gallate (EGCG) was constructed through electrostatic interaction and phenylboronic acid-catechol interaction between poly(ethylene glycol)-block-poly(lysine-co-lysine-phenylboronic acid) (PEG-PLys/PBA) and EGCG. (greenmedinfo.com)
  • Anticancer drug doxorubicin (DOX) was loaded in the polymeric micelles. (polymer.cn)
  • Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking. (biomedsearch.com)
  • We have recently developed a novel strategy that utilizes micelles self-assembled from recombinant polypeptides after attaching doxorubicin, a cancer drug, to deliver the drug," explained Dr. Chilkoti, who is also the director of the Duke University Center for Biologically Inspired Materials and Material Systems. (fiercebiotech.com)
  • Publications] K.Kataoka: 'Sontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline' Macromolecules. (nii.ac.jp)
  • Amifsotine, a hydrophilic and extremely short half-life cytoprotective agent, was loaded based on chelating complex micelles (CCM) in order to provide the protection from radiation exposure. (omicsonline.org)
  • In the study described herein, the chelating complex micelles (CCM) composed of ferrous ion, poly(ethylene glycol)- block -poly (glutamic acid) (PEG-b-PGA), and cytoprotectant amifostine (WR-2721) are designed for the prevention of radiation damage. (omicsonline.org)
  • The formation of the complex micelles is shown in Figure 1. (docme.ru)
  • Transmission electron microscopy indicated that mainly wormlike cylindrical micelles were formed, even with highly hydrophilic polymers. (rsc.org)
  • An endovascular stent comprising an expandable framework including a plurality of interconnected segments, and a plurality of entangled cylindrical micelles disposed on the expandable framework. (google.com)
  • Each of the plurality of cylindrical micelles may be loaded with a therapeutic agent. (google.com)
  • 2. The stent of claim 1 , wherein the cylindrical micelles are loaded with a therapeutic agent. (google.com)
  • 3. The stent of claim 2 , wherein the therapeutic agent is encapsulated within the core region of each of the cylindrical micelles. (google.com)
  • 8. The stent of claim 1 , wherein the plurality of cylindrical micelles are disposed adjacent the inner surface of the expandable framework. (google.com)
  • 9. The stent of claim 8 , wherein a portion of the inner surface of the expandable framework is accessible through the plurality of cylindrical micelles. (google.com)
  • 12. The stent of claim 1 , wherein the plurality of cylindrical micelles surround each interconnected segment of the expandable framework. (google.com)
  • 13. The stent of claim 1 , wherein the plurality of cylindrical micelles are adhered to a surface of the expandable framework. (google.com)
  • 15. The stent of claim 1 , wherein the plurality of cylindrical micelles forms a fibrous structure. (google.com)
  • 16. The stent of claim 1 , wherein the plurality of cylindrical micelles has an average pore size of about 1 nanometer to about 1000 nanometers. (google.com)
  • 17. The stent of claim 1 , wherein each of the cylindrical micelles has a diameter of about 10 nanometers to about 50 nanometers. (google.com)
  • 18. The stent of claim 1 , wherein each of the cylindrical micelles has a length of about 0.1 micrometer to about 100 micrometers. (google.com)
  • The present disclosure generally relates to medical devices including cylindrical micelles placed therewith. (google.com)
  • More specifically, the disclosure pertains to prostheses, such as prosthetic grafts and endovascular stents incorporating cylindrical micelles. (google.com)
  • The critical micelle concentrations (CMCs) of poly(Arb)- R x were determined as 1.3-5.2 mg mL −1 by the surface tension method. (rsc.org)
  • All the polymeric micelles exhibited ultra-small particle sizes with approximately 50 nm, high relaxation rate, and low toxicity even at high iron concentrations. (medsci.org)
  • Furthermore, in vitro cell experiments demonstrated that fluorescently labeled micelles were successfully taken up by HeLa cells while cell viability remained high even at high micelle concentrations. (wur.nl)
  • The result is an increase in the capture of carotenoids by our gathering cells, an improvement in absorption and bioavailability, and an ultimate increase in carotenoid concentrations at the target tissue (Macular Pigment Optical Volume). (macuhealth.com)
  • The presence of detergents at increasing micelle concentrations, on the other hand, resulted in moderate lipid binding to soluble proteins. (diva-portal.org)
  • PEO-PCL based worm-like filomicelles appear to be promising pharmaceutical nanocarriers with improved solubilization efficiency and comparable stability to spherical micelles, as well as better safety and efficacy in vitro compared to the prevalent Cremophor ® EL TAX formulation. (springer.com)
  • Polymeric micelles for delivery of poorly soluble drugs: preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids. (springer.com)
  • Stabilization of the micelles below the critical micelle concentration was demonstrated using a pH-reversible crosslinking mechanism, with proof-of-concept demonstrated in both in vitro and in vivo models. (hindawi.com)
  • Zhang Y, Pan J, Xu Q, Li H, Wang J, Zhang C, Hong G. Synthesis and in vitro experiments of carcinoma vascular endothelial targeting polymeric nano-micelles combining small particle size and supermagnetic sensitivity. (medsci.org)
  • The cRGD-terminated γ-Fe 2 O 3 -loaded polymeric micelles targeting to carcinoma vascular endothelial cells, were characterized in particle size, morphology, loading efficiency and so on, especially high MRI sensitivity in vitro. (medsci.org)
  • Bahadori F, Kocyigit A, Onyuksel H, Dag A, Topcu G. Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation. (mdpi.com)
  • After conducting in vitro and vivo toxicology experiments, we also examined the active targeting capability of the micelles upon dual-mode imaging in vivo. (biomedcentral.com)
  • By performing in vitro and vivo toxicology assay, the micelles had good biocompatibility. (biomedcentral.com)
  • The loaded worm-like micelles of the present invention are particularly suited for the stable and controlled transport, delivery and storage of materials, either in vivo or in vitro. (freepatentsonline.com)
  • The DOX loaded polymeric micelles exhibited efficient anticancer activity in vitro. (polymer.cn)
  • Furthermore, the in vitro cytotoxicity results affirmed that M-PMM could serve as a better alternative for treating and preventing human colorectal cancer. (benthamscience.com)
  • This paper describes the synthesis of long-chain-alkylated poly(arbutin)s (poly(Arb)- R x , where R = alkyl-chain length and x = degree of substitution (DS)) and their aqueous micelle formation. (rsc.org)
  • Recently, we have succeeded in following the complete kinetics of micelle formation from a pool of monomers to globular micelles using time-resolved SAXS combined with stopped-flow mixing [2]. (esrf.eu)
  • The upturn of intensity at low Q values indicates the formation of worm-like micelles. (esrf.eu)
  • Mixing of these polymers in aqueous solution followed by heating to 50 °C resulted in the formation of thermosensitive flower-like micelles. (wur.nl)
  • Karvar M, Strubbe F, Beunis F, Kemp R, Goulding M, Neyts K. Study of double layer formation of Aerosol OT inverse micelles in nonpolar liquids. (ugent.be)
  • These results highlight how mechanochromic polymer sensors can be used to detect the molecular transitions occur during supramolecular structure formation with high precision. (wur.nl)
  • For membrane proteins, lipids are incorporated into the surrounding micelle in solution, and complex formation occurs independently of the ESI process. (diva-portal.org)
  • The formation of a micelle is a response to the amphipathic nature of fatty acids, meaning that they contain both hydrophilic regions (polar head groups) as well as hydrophobic regions (the long hydrophobic chain). (wikibooks.org)
  • Micelle formation is favored when the cross-sectional area of the head group is greater than that of the acyl side chain(s), as in free fatty acids, more notably lysophospholipids (phospholipids lacking one fatty acid), and many detergents, such as sodium dodecyl sulfate. (wikibooks.org)
  • Separating the water from the hydrophobic tails during micelle formation increases the disorder of the system, and this increase in entropy is favorable. (wikibooks.org)
  • For this effect only very small amounts of enzyme are required, some bacteria as the ones used for yogurt and cheese production produce these enzymes in a natural way resulting in curd formation in the same way as described above. (madsci.org)
  • The formation of ellipsoidal mixed micelles was confirmed by small angle neutron scattering (SANS) analysis. (benthamscience.com)
  • This fusion can result in the formation of mem- brane surface pores and tubes causing cell leakage. (yudu.com)
  • The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. (uzh.ch)
  • Among the various alternatives for CrEL, the polymeric micelles have a great potential in terms of water solubility, in vivo stability, and the nanoscopic size of the micellar structure. (aacrjournals.org)
  • One of the classical approaches to improve the aqueous solubility of hydrophobic drugs, which is still being widely used in the pharmaceutical industry, is to solubilize them in surfactant micelles [ 4 , 5 ]. (ijpsonline.com)
  • Polymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. (dovepress.com)
  • Taking advantage of the heat, ethanol, and pH mediated micelle disassociation, it was possible to improve the solubility of caseins in fluid milk via esterification. (tennessee.edu)
  • which in turn resulted in a better solubility at low pH values. (tennessee.edu)
  • Study was conducted as a part of determination of Critical Micelle Concentration (CMC) and water solubility was derived in the study. (europa.eu)
  • For surface active substances the critical micelle concentration (CMC) method is used as an alternative to the water solubility. (europa.eu)
  • Under the study conditions, the water solubility (critical micelle concentration) of the test substance was determined to be 0.73 g/L at 21.31°C. (europa.eu)
  • A study was conducted to determine the water solubility of the test substance, C12-14 TMAC (97% active) using the critical micelle concentration (CMC) method, which is recommended for surface active substances. (europa.eu)
  • The water solubility of the test substance was determined using critical micelle concentration (CMC) method, which is recommended for surface active substances (Oosterwijk, 2020). (europa.eu)
  • The study was well conducted according to guidelines and critical micelle concentration (CMC) method is used as an alternative to the water solubility. (europa.eu)
  • The water solubility was determined using a guideline based on critical micelle concentration (CMC). (europa.eu)
  • Decreasing the temperature to 10 °C only affected the size of the micelles (increased to 90 nm) but hardly affected the polydispersity index (PDI) and aggregation number (N agg ) confirming covalent stabilization of the micelles by NCL. (wur.nl)
  • This resulted in a reduction on the size of the micelles. (tennessee.edu)
  • An inclusion-interaction assembly strategy was used to construct novel pH/redox responsive core-shell micelles with hydrophobic drug as the core and hydrophilic polymer as the shell. (scirp.org)
  • It self-assembled into pH/redox responsive core-shell micelles in distilled water. (scirp.org)
  • With an increase in temperature or pH value, the core-shell micelles convert into a new type of micelle, where soluble chains stretch out from the core through the now collapsed shell. (docme.ru)
  • Due to their unique size range (20-150 nm), micelles are able to avoid renal clearance (typically less than 20 nm) and uptake by the liver and spleen (particles greater than 150 nm). (hindawi.com)
  • Human hepatic carcinoma vascular endothelial cells (T3A) were cultured with the resulting micelles to assess the micelle uptake using Prussian blue staining and the cell signal intensity using MRI. (medsci.org)
  • The cellular study showed that Val-PMs/Phe-PMs had a high PepT1 affinity, resulting in a higher drug uptake and transcellular transport than TP-PMs. (dovepress.com)
  • This paper probes and discusses possible mechanisms by which the P105 micelles and the ultrasound drug delivery system induce drug uptake by cancer cells. (biomedcentral.com)
  • In order to test the hypothesis that endocytosis is involved in micelle uptake, a probe that fluoresces more strongly in acidic environments was used, namely Lysosensor Green (Molecular Probes, L-7535, Eugene, OR). (biomedcentral.com)
  • We observed more cellular uptake of the micelles with the help of anti-human CD326 grafted onto the micelles. (biomedcentral.com)
  • While flow cytometry is commonly used for characterization of DOX intracellular uptake, the above aspects of DOX fluorescence may significantly complicate interpretation of flow cytometry results. (biomedsearch.com)
  • Results showed an enhanced uptake from nile red-GCP nanoparticles compared to compound in solution. (nsti.org)
  • Nano-scaled micelles were designed to extend the half-lives of drugs and reduce the uptake by reticuloendothelial system (RES) [ 1 ]. (omicsonline.org)
  • During the self-assembly of PEG-PCL micelles, superparamagnetic γ-Fe 2 O 3 nanoparticles (11 nm) was loaded into the hydrophobic core. (medsci.org)
  • In aqueous solution above a critical micellar concentration ( cmc ), they self-assemble into micelles consisting of a hydrophobic core of tail groups surrounded by a shell of hydrophilic head groups and water. (esrf.eu)
  • To achieve this effect at a sufficient level, it will be important to emphasize the core-shell structure of the micelle in order to inhibit nonspecific intertactions of the hydrophobic core of the micelle with the biocomponents (e.g. (nii.ac.jp)
  • We have demonstrated that utilization of nano-sized micelles modified with Tat can facilitate direct intranasal brain delivery. (springer.com)
  • Synthethic "copolymer micelles" are cell-like delivery methods for cancer medication inside the body, but researchers at Purdue University believe they might have discovered that these nano-sized micelles can also help to fix spinal cord injuries , according to PopSci.com. (seriousaccidents.com)
  • however, conventional micelles do not have long-term stability in complex biological environments such as plasma. (hindawi.com)
  • PMs with unique properties such as high stability, low critical micelle concentration (CMC), biodegradability, small particle size and high loading capacity are suitable candidates to produce drug delivery systems [ 2 , 3 ]. (ijpsonline.com)
  • RES) by covering the core with a hydrated outer shell which will provide higher stability of the micelle structure in blood. (nii.ac.jp)
  • We found that the micelles owned superior imaging properties and long-time stability based on multiple characterizations. (biomedcentral.com)
  • The phenylboronic acid-catechol interaction endowed the PIC micelles with high stability under physiological condition. (greenmedinfo.com)
  • Herein we demonstrate that unequivocal step-change shifts in micelle populations occur over several weeks following transfer into a highly selective solvent.Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein systems.Moreover, the non-equilibrium micelle size increase can have a major impact on the assumed stability of solution assemblies, for which performance is dictated by nanocarrier size and structure. (nih.gov)
  • Moreover, the non-equilibrium micelle size increase can have a major impact on the assumed stability of solution assemblies, for which performance is dictated by nanocarrier size and structure. (nih.gov)
  • The PEG corona also enhanced the stability of the mixed micelles formulation as observed in the zeta potential data. (benthamscience.com)
  • According to Dr. MacKay, a co-corresponding author of the report, the stability of micelles is important to their success or failure as drug delivery systems. (fiercebiotech.com)
  • The stability of micelles has thermodynamic and kinetic components," he said. (fiercebiotech.com)
  • 20-25 Unfortunately, the selectivity of C-C coupling over C-O coupling for βArb systems was found to be generally poor, and the number average molecular weight ( M n ) of the resulting polymers was limited to 3200, most likely due to the occurrence of enzyme-catalyzed equilibrium polymerization. (rsc.org)
  • We then examined how the self-assembly of these micelles was affected when we blended polymers of different length or when we let them crystallize. (uio.no)
  • Methotrexate-conjugated polymer hybrid micelles (M-PHMs) were prepared by self-assembly of two functional amphiphilic polymers (MTX-PEI-LA and mPEG-LA) at an optimized weight ratio. (thno.org)
  • Physical parameters of optimized micelles comprising particle size, zeta potential, drug loading efficacy, and drug release profile were determined. (ijpsonline.com)
  • The results reveal that the nanomicelles have formed with mean particle size of 191 nm and zeta potential of -9.45 mv. (ijpsonline.com)
  • The optimized PEGylated mixed micelles of meloxicam (M-PMM) had a high percent entrapment efficiency of 73.6% ± 0.72% and mean particle size of 132 nm ± 67nm. (benthamscience.com)
  • The resulting CCM-Ami monodispersed with a mean particle size 25 nm and showed a slow release behavior as compared to amifostine. (omicsonline.org)
  • In cytotoxicity tests that compare to the clinically prevalent solubilizer, Cremophor ® EL, both micellar carriers are far less toxic, and both types of TAX-loaded micelles also show fivefold greater anticancer activity on A549 human lung cancer cells. (springer.com)
  • The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using Sulforhodamine-B, WST-1, Acridine Orange/Ethidium Bromide and alkaline single-cell gel electrophoresis assays. (mdpi.com)
  • 42% hydrophilic polyethylene oxide (PEO) or polyethylene glycol (PEG) and at least one hydrophobic block that drives self-assembly of the worm-like micelle. (freepatentsonline.com)
  • 8. The worm-like micelle of claim 1, wherein the worm-like micelle is biocompatible. (freepatentsonline.com)
  • In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to efficiently deliver a small interfering RNA (siRNA) targeting the PLK-1 gene while offering a hydrophobic environment for encapsulation of lipophilic drugs such as camptothecin is developed. (rsc.org)
  • Described herein is polymer micelle drug delivery system that enables encapsulation and stabilization of a wide variety of chemotherapeutic drugs in a single platform. (hindawi.com)
  • Taken together, this made epothilone D attractive for encapsulation in a stabilized polymer micelle for improved safety and efficacy. (hindawi.com)
  • For efficient encapsulation in micelle cores, DOX is usually deprotonated, which removes the positive charge and enhances hydrophobicity of DOX molecule. (biomedsearch.com)
  • Drugs can be loaded into polymeric micelles through physical encapsulation, covalent bonding, or electrostatic interactions. (omicsonline.org)
  • The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM) made of a lipid-based amphiphilic distearoyl-sn-glycero-phosphatidylethanolamine-polyethylene glycol (PEG)-2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and PEG. (mdpi.com)
  • Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-α-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs). (dovepress.com)
  • The way this anti-paralysis shot works is that the outer shell of micelles consist of polyethylene glycol (PEG), which can hone in on damaged axons - nerve cells in the body - acting like bio-safe plaster to the area of injury. (seriousaccidents.com)
  • Association colloids such as phospholipid reverse micelles could increase the rate of lipid oxidation in bulk oils. (ebscohost.com)
  • In addition to phospholipids, other surface active minor components in commercial oils such as free fatty acids may impact lipid oxidation rates and the physical properties of reverse micelles. (ebscohost.com)
  • CDCA and other bile acids form micelles, which facilitate lipid digestion. (wikipedia.org)
  • The size of a micelle is more limited than that of a lipid bilayer. (wikibooks.org)
  • The integral membrane enzyme diacylglycerol kinase (DAGK) has long been thought to require the presence of lipid as an obligate 'cofactor' in order to be catalytically viable in micelles. (mendeley.com)
  • The lesson will teach students how to make a primitive soap, understand the basic chemistry behind soap, conceptualize how soap removes debris via micelle aggregation, and identify what hard water is and its effect on micelle aggregation. (uakron.edu)
  • Students will be able to assess why hard water affects the aggregation of soap micelles. (uakron.edu)
  • Further studies will be needed to validate the therapeutic potential of fisetin and fisetin micelles in ovarian cancer treatment. (biomedcentral.com)
  • The present findings demonstrate that cinnamaldehyde-loaded and poly(cinnamaldehyde) micelles possess vasodilator properties, but that the mechanism underlying the relaxation that they cause differs from that of cinnamaldehyde, and thus could be used both to relieve coronary vasospasm and for therapeutic drug delivery. (dovepress.com)
  • Our results indicate that simvastatin targeted delivery to LSEC is a promising therapeutic approach for CLD. (physiciansweekly.com)
  • The same was true for the DOX encapsulated in micelles or nanodroplets, which may explain their low therapeutic efficacy in the absence of ultrasound. (biomedsearch.com)
  • Microbubble cavitation results in the transient permeabilization of both plasma and nuclear membranes, thus allowing DOX penetration into the cell nuclei, which dramatically enhances therapeutic efficacy of DOX-loaded nanodroplet systems. (biomedsearch.com)
  • Herein, we reported a novel polymeric micelle with π-π conjugated cinnamate moiety on glycerol dendrimer as lipophilic segment , the modified dendritic segment was connected to poly(ethylene glycol) (PEG) via click chemistry. (polymer.cn)
  • These problems are illustrated in the experiments on the intracellular trafficking of DOX encapsulated in poly(ethylene glycol)-co-polycaprolactone (PEG-PCL) micelles or PEG-PCL stabilized perfluorocarbon nanodroplets, with and without the application of ultrasound used as an external trigger. (biomedsearch.com)
  • Physical properties of DOPC reverse micelles in the presence of free fatty acids in bulk oils were also investigated by the small angle X-ray scattering technique. (ebscohost.com)
  • Since their discovery over a century ago, surfactant micelles have been a topic of intense interest in both academic and technological research [1]. (esrf.eu)
  • Typically surfactant micelles aggregate into highly dynamic nanostructures consisting of either spherical or non-spherical shapes such as ellipsoidal, cylindrical and discoidal shapes. (esrf.eu)
  • In addition, the efficacy of fisetin and fisetin-micelles in vivo was determined by using immunocompromised mice. (biomedcentral.com)
  • Background Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. (tudelft.nl)
  • The fission process exploits the finding that the PCL cores are fluid, rather than glassy or crystalline, and core-loading of the hydrophobic anticancer drug delivery, paclitaxel (TAX) shows that the worm-like micelles load and solubilize twice as much drug as spherical micelles. (springer.com)
  • in contrast, DOX fluorescence is increased after binding to the histone or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles. (biomedsearch.com)
  • A definitive structure of the native casein micelle structure continues to elude researchers. (tennessee.edu)
  • LogP=-2.084) into raw skim milk did not result on the peptide being found associated with isolated casein micelles. (tennessee.edu)
  • In the conditions of the chill step, beta casein and calcium migrated out of the micelles. (tennessee.edu)
  • Applying a short (4 weeks) instead of a conventional (8 weeks) dry period resulted in increased plasmin activity in milk, but did not affect the β-casein fraction. (wur.nl)
  • At low somatic cell counts, dry period reduction or omission only tended to result in an increased plasmin activity due a higher casein concentration in milk. (wur.nl)
  • These proteins are present in the milk as large aggregates named casein micelles, because of their large size [200-500 nm] milk has that white appearance. (madsci.org)
  • These micelles remain in solution because ONE of the 4 different caseins (k-casein) has the particular characteristic to keep these aggregates in solution. (madsci.org)
  • What happens to milk when meat tenderizer is added is that proteins with a particular function [named proteolytic enzymes*] interact with that protecting k-casein and as a result it loses its protective function. (madsci.org)
  • Micelles were prepared by solvent-substituting technique in the presence of peptide models to obtain peptide-loaded polymeric micelles. (nii.ac.jp)
  • Pyrene in the micelle was shown to be stably entrapped in the core, suggesting a promising feature of these micelles as novel peptide carriers. (nii.ac.jp)
  • In this study, we engineered hybrid metal oxide-peptide amphiphile micelles (HMO-Ms) that combine an inorganic, magnetic iron oxide or manganese oxide inner core with organic, fibrin-targeting peptide amphiphiles, consisting of the sequence CREKA, for potential MRI imaging of thrombosis on atherosclerotic plaques. (biomedcentral.com)
  • Hybrid metal oxide-peptide amphiphile micelles, consisting of an iron oxide (Fe-Ms) or manganese oxide (Mn-Ms) core with CREKA peptides, were self-assembled into 20-30 nm spherical nanoparticles, as confirmed by dynamic light scattering and transmission electron microscopy. (biomedcentral.com)
  • Re-formulations including microcapsules and polymer complex were investigated to assess the efficacy for radioprotection, but no better result was found [ 14 - 16 ]. (omicsonline.org)
  • DLS showed that the micelles were stable in aqueous solution. (scirp.org)
  • Micro-Micelle™ is a revolutionary upgrade to our patented 10-10-2 formulation. (macuhealth.com)
  • Figure 1 depicts the typical evolution of background-subtracted normalised SAXS intensities upon mixing solutions of 1 weight % of SDS with 2 M NaCl, corresponding to a final salt concentration of 1 M. At this salt concentration, worm-like micelles form spontaneously. (esrf.eu)
  • Micelles form spontaneously in water, as stated above this spontaneous arrangement is due to the amphipathic nature of the molecule. (wikibooks.org)
  • As far as we know, the present study is the first time to demonstrate the potency of both fisetin and fisetin micelles inducing apoptosis in ovarian cancer cells. (biomedcentral.com)
  • The results demonstrate that micelle formulated ICG can be visualized in the retinal vasculature and laser-induced CNV showing overall stronger signal intensity as compared to conventional ICG for all tested dosages. (arvojournals.org)
  • These results demonstrate the potential of these micelles for drug delivery applications. (wur.nl)
  • With good biocompatibility and excellent imaging properties of the micelles, our results uncover efficient active homing of those micelles after intravenous injection, and undoubtedly demonstrate the as-obtained micelles holds great potential for early pancreatic cancer diagnosis in the future and would pave the way for the following biomedical applications. (biomedcentral.com)
  • Herein we demonstrate that unequivocal step-change shifts in micelle populations occur over several weeks following transfer into a highly selective solvent. (nih.gov)
  • Critical micelle concentration of final conjugate was determined using the pyrene fluorescence method. (ijpsonline.com)
  • However, DOX fluorescence depends on a number of factors that should be taken into consideration when interpreting results of DOX fluorescence measurements. (biomedsearch.com)
  • Multiple lines of evidence indicated that fisetin and fisetin micelles induce apoptosis in ovarian cancer cells in a dose-dependent manner. (biomedcentral.com)
  • We conclude that the lipids in the resulting complexes interact predominantly with sites located in the transmembrane segments, resulting in nativelike complexes that can be interrogated by MS. (diva-portal.org)
  • However, when the lipids form micelles the hydrophobic tails interact with each other rather than with water. (wikibooks.org)
  • The structure of lipids in aqueous solutions are usually bilayer sheets of lipids rather than spherical micelles. (wikibooks.org)
  • Medium chain functional lipids form dou- ble-layered micelles that can fuse with the bacterial cell membrane. (yudu.com)
  • 5. The nucleic acid-encapsulating polymer micelle complex according to any one of Claims 1 to 4, wherein the DNA and the cationic polymer chain block bonded to the DNA due to an electrostatic interaction form a core portion, and the uncharged hydrophilic polymer chain block forms a shell portion. (go.jp)
  • Electrostatic interaction has also been attempted for the preparation of polymeric micelles. (omicsonline.org)
  • Students will be able to describe the molecular structure of a micelle. (uakron.edu)
  • Remarkably, at stoichiometries close to full charge compensation a gradual transition from single molecular complexes to multimolecular micelles is observed. (wur.nl)
  • Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. (mdpi.com)
  • Typical polymeric micelles consist of a compact core formed by the insoluble blocks of the polymer and a stretched shell formed by the soluble blocks so that the inner core can serve as a nanocontainer for various substances. (docme.ru)
  • Worm-like and spherical micelles are both prepared here from the same amphiphilic diblock copolymer, poly(ethylene oxide)- b -poly (ε-caprolactone) (PEO [5 kDa]-PCL [6.5 kDa]) in order to compare loading and delivery of hydrophobic drugs. (springer.com)
  • As these platforms have shown very promising results for a list of other solid tumors, it is important to examine what the current barriers are to transforming these particles into delivery systems that may one day benefit GBM patients. (frontiersin.org)
  • The dark patches represent more dense areas in the micelles which coincide with the higher content of HPMA-Cys/ETSA close to the PEG chain revealed by the polymerization kinetics study. (wur.nl)
  • CryoTEM images showed micelles with an uniform spherical shape and dark patches close to the corona of micelles were observed in the tomographic view. (wur.nl)
  • Fatty acids from Glycolipids and phospholipids with their two hydrophobic chains are too bulky to fit into the a spherical shape as micelles do. (wikibooks.org)
  • By protecting a membrane protein complex within a n -dodecyl-β- d -maltoside micelle, we demonstrated a powerful strategy that will enable the subunit stoichiometry and ligand-binding properties of membrane complexes to be determined directly, by precise determination of the masses of intact complexes and dissociated subunits. (sciencemag.org)
  • As a result of these difficulties, progress has been limited, with relatively few examples of intact membrane protein complexes having been reported. (sciencemag.org)
  • It resulted in a micelle, in which only hydrogen bonds rather than covalent bonds existed between core and shell. (scirp.org)
  • Further, it achieved the integration of drug-loading and self-assembly in preparing drug-loaded micelles, avoiding the multiple steps used in the covalent-bond method. (scirp.org)
  • In DLS measurement, the average micelle diameters were 225-616 nm, and micelle size decreased with increasing DS because of increased stabilization by hydrophobic alkyl substituents. (rsc.org)
  • Subsequently, native chemical ligation in the core of micelles resulted in stabilization of the micelles with a Z-average of 65 nm at body temperature. (wur.nl)
  • In this study, the effects of free fatty acids on changes in the critical micelle concentration (CMC) of 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) in stripped corn oil (SCO) were determined by using the 7,7,8,8-tetracyanoquinodimethane solubilization technique. (ebscohost.com)
  • The polar head groups of micelles form the outside surface of the molecule, facing the aqueous environment, and their hydrophobic chains are clustered in the interior, where water is excluded since they are nonpolar. (wikibooks.org)
  • Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug-siRNA combo-therapies. (rsc.org)
  • Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. (springer.com)
  • Especially they can form micelles in a specific solvent, which make it possible to function as a drug carrier. (rsc.org)
  • Recently, the biodegradable polymeric micelles are gradually gaining attention due to high bioavailability, better selectivity and accurate targeting in the form of drug delivery systems. (biomedcentral.com)
  • The polymeric micelles have an important place in the field of drug delivery systems. (nii.ac.jp)
  • Publications] M.Yokoyama: 'Development of micelle-forming polymeric drug with superior anticancer activity' Polymeric Drugs and Drug Administration,Amer.Chem.Soc.Symposium Series 545. (nii.ac.jp)
  • In this study, native chemical ligation (NCL) was used as a selective cross-linking method to form core-cross-linked thermosensitive polymeric micelles for drug delivery applications. (wur.nl)
  • We assumed that, if a hydrophilic β-CD containing polymer and a dimer of hydrophobic drug could form an amphiphilic inclusion complex, with the dimer being partially embedded into the cavity of β-CD moiety, the complex should be able to self-assemble into a micelle, with dimer as core and the polymer as shell. (scirp.org)
  • This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. (biomedcentral.com)
  • The results of our experiments show that the increase in drug accumulation in the cells as a result of ultrasonication is not due to an increase in endocytosis due to ultrasonication. (biomedcentral.com)
  • We hypothesize that sonoporation plays an important role in the acoustically activated drug delivery of chemotherapy drugs delivered from Pluronic micelles. (biomedcentral.com)
  • 3) ultrasound induces an increase in the active endocytosis of the micelles (with drug) into the cell. (biomedcentral.com)
  • Simvastatin has been tested as vasoprotective drug in experimental models of CLD showing promising results, but also limiting adverse effects. (physiciansweekly.com)
  • Polymeric micelles are important nanovehicles for anticancer drug delivery. (polymer.cn)
  • The lipophilic segment in polymeric micelle is an important factor to affect the drug loading properties. (polymer.cn)
  • However, MTX monotherapy often results in drug resistance and irreversible joint damage due to its slow onset of action and long duration [ 15 - 18 ]. (thno.org)
  • Thus, we believe that genetically encoded polypeptide micelles are likely to play an increasing role in the design of next generation nanoscale carriers of drug and imaging agents. (fiercebiotech.com)
  • As a result, developing a new drug delivery carrier represents a major target for an unmet need within the drug industry [ 10 ]. (omicsonline.org)