Respiratory syncytial viruses. Medical search

A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.

Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.

Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.

An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.

Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.

Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.

A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.

Inflammation of the BRONCHIOLES.

Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.

A genus of the subfamily PNEUMOVIRINAE, containing two members: Turkey rhinotracheitis virus and a human Metapneumovirus. Virions lack HEMAGGLUTININ and NEURAMINIDASE.

Proteins found in any species of virus.

Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Substances elaborated by viruses that have antigenic activity.

A general term for diseases produced by viruses.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

Inflammation of the lung parenchyma that is caused by a viral infection.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.

Process of growing viruses in live animals, plants, or cultured cells.

The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

Viruses whose genetic material is RNA.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

Ribonucleic acid that makes up the genetic material of viruses.

A species of the genus PNEUMOVIRUS causing pneumonia in mice.

Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.

Established cell cultures that have the potential to propagate indefinitely.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.

A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.

Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.

An infant during the first month after birth.

Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.

A species of RESPIROVIRUS, subfamily PARAMYXOVIRINAE, most often seen in conjunction with a secondary infection of MANNHEIMIA HAEMOLYTICA resulting in pneumonic pasteurellosis (PASTEURELLOSIS, PNEUMONIC).

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).

Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans.

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

A genus of the family PARAMYXOVIRIDAE (subfamily PNEUMOVIRINAE) where the human and bovine virions have neither hemagglutinin nor neuraminidase activity. RESPIRATORY SYNCYTIAL VIRUS, HUMAN is the type species.

A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.

The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

Antibodies produced by a single clone of cells.

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.

Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.

The functional hereditary units of VIRUSES.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.

The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.

A subfamily of MURIDAE found nearly world-wide and consisting of about 20 genera. Voles, lemmings, and muskrats are members.

A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.

Vaccines or candidate vaccines used to prevent infection with parainfluenza viruses in humans and animals.

Viruses parasitic on plants higher than bacteria.

Viruses whose nucleic acid is DNA.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

A species of RUBULAVIRUS associated particularly with acute laryngotracheitis (CROUP) in children aged 6 months to 3 years.

Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.

Delivery of medications through the nasal mucosa.

The confinement of a patient in a hospital.

A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.

The relationships of groups of organisms as reflected by their genetic makeup.

Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.

Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.

The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Sites on an antigen that interact with specific antibodies.

Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

Virus diseases caused by the PICORNAVIRIDAE.

A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Deoxyribonucleic acid that makes up the genetic material of viruses.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.

Disease having a short and relatively severe course.

Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.

Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).

The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.

Elements of limited time intervals, contributing to particular results or situations.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.

Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.

The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

A species of ALPHAVIRUS isolated in central, eastern, and southern Africa.

Genotypic differences observed among individuals in a population.

The outer protein protective shell of a virus, which protects the viral nucleic acid.

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

Virus diseases caused by the ORTHOMYXOVIRIDAE.

Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

The interactions between a host and a pathogen, usually resulting in disease.

Pathological processes involving the NASOPHARYNX.

Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Group of chemokines with the first two cysteines separated by three amino acids. CX3C chemokines are chemotactic for natural killer cells, monocytes, and activated T-cells.

Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.

Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.

Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.

Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.

A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).

Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.

A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.

The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Viruses that produce tumors.

One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.

Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.

Diseases of domestic and mountain sheep of the genus Ovis.

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.

A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.

Proteins prepared by recombinant DNA technology.

A copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.

Child hospitalized for short term care.

A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.

Infection of the lung often accompanied by inflammation.

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Infections with viruses of the genus RUBULAVIRUS, family PARAMYXOVIRIDAE.

A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Viruses which produce a mottled appearance of the leaves of plants.

Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.

A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.

Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.

A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).

The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.

Methods for using more than one primer set in a polymerase chain reaction to amplify more than one segment of the target DNA sequence in a single reaction.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.

Detection of antibody to bovine syncytial virus and respiratory syncytial virus in bovine fetal serum. (1/1481)

Batches of commercial fetal bovine serum, described by the suppliers as antibody-free, all contained antibody to bovine syncytial virus (BSV) when tested by indirect immunofluorescence. Antibody to bovine respiratory syncytial virus (RSV) was not detected in these sera. Twenty-four percent of individual fetal bovine sera contained antibody to BSV, and 14% contained antibody to RSV when tested by indirect immunofluorescence. BSV antibody titers in fetal sera from dams with high BSV antibody levels were variable but always higher than RSV antibody titers. Radial immunodiffusion studies with BSV-positive sera revealed the presence of immunoglobulin M (IgM), IgG, and IgA, but the quantity of these immunoglobulins was not directly related to the BSV antibody titers. The evidence suggests that the antibody present in fetal sera arose as the result of infection rather than from maternal transfer across the placenta. (+info)

Maternal immunization. (2/1481)

Maternal immunization can enhance passive immunity of infants to pathogens that cause life-threatening illnesses. In most instances, immunization during pregnancy will provide important protection for the woman as well as for her offspring. The tetanus toxoid and influenza vaccines are examples of vaccines that provide a double benefit. Other vaccines under evaluation include those for respiratory syncytial virus, pneumococci, group B streptococci, and Haemophilus influenzae type b. Although most IgG antibody crosses the placenta in the third trimester, the process is time-dependent, dictating that immunization should be accomplished ideally at least 6 weeks prior to delivery. IgG1 antibodies are transferred preferentially. Maternal immunization has not interfered with active immunization of the infant. Inactivated vaccines administered in the third trimester of pregnancy pose no known risk to the woman or to her fetus. (+info)

Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines. (3/1481)

A number of antibodies generated during human respiratory syncytial virus (RSV) infection have been cloned by the phage library approach. Antibodies reactive with an immunodominant epitope on the F glycoprotein of this virus have a high affinity for affinity-purified F antigen. These antibodies, however, have a much lower affinity for mature F glycoprotein on the surface of infected cells and are nonneutralizing. In contrast, a potent neutralizing antibody has a high affinity for mature F protein but a much lower affinity for purified F protein or F protein in viral lysates. The data indicate that at least two F protein immunogens are produced during natural RSV infection: immature F, found in viral lysates, and mature F, found on infected cells or virions. Binding studies with polyclonal human immunoglobulin G suggest that the antibody responses to the two immunogens are of similar magnitudes. Competitive binding studies suggest that overlap between the responses is relatively limited. A mature envelope with an antigenic configuration different from that of the immature envelope has an evolutionary advantage in that the infecting virus is less subject to neutralization by the humoral response to the immature envelope that inevitably arises following lysis of infected cells. Subunit vaccines may be at a disadvantage because they most often resemble immature envelope molecules and ignore this aspect of viral evasion. (+info)

Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. (4/1481)

The NS2 and SH genes of respiratory syncytial virus (RSV) have been separately deleted from a recombinant wild-type RSV strain, A2 (M. N. Teng and P. L. Collins, J. Virol. 73:466-473, 1998; A. Bukreyev et al., J. Virol. 71:8973-8982, 1997; and this study). The resulting viruses, designated rA2DeltaNS2 and rA2DeltaSH, were administered to chimpanzees to evaluate their levels of attenuation and immunogenicity. Recombinant virus rA2DeltaNS2 replicated to moderate levels in the upper respiratory tract, was highly attenuated in the lower respiratory tract, and induced significant resistance to challenge with wild-type RSV. The replication of rA2DeltaSH virus was only moderately reduced in the lower, but not the upper, respiratory tract. However, chimpanzees infected with either virus developed significantly less rhinorrhea than those infected with wild-type RSV. These findings demonstrate that a recombinant RSV mutant lacking either the NS2 or SH gene is attenuated and indicate that these deletions may be useful as attenuating mutations in new, live recombinant RSV vaccine candidates for both pediatric and elderly populations. The DeltaSH mutation was incorporated into a recombinant form of the cpts248/404 vaccine candidate, was evaluated for safety in seronegative chimpanzees, and can now be evaluated as a vaccine for humans. (+info)

Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. (5/1481)

RD3-0028, a benzodithiin compound, has antiviral activity against respiratory syncytial virus (RSV) in cell culture. We used a mouse model of RSV infection to determine the in vivo effect of RD3-0028. Cyclophosphamide (CYP)-treated, immunosuppressed mice were inoculated intranasally. The lungs of the mice were removed on day 4. The virus titers of the lungs of RD3-0028-treated mice were compared to the virus titers of the lungs of virus-inoculated, untreated control mice. In an effort to increase the therapeutic effectiveness of this compound, RD3-0028 was administered by aerosol to RSV-infected mice by using a head-exposure system. Aerosols generated from reservoirs containing RD3-0028 (7 mg/ml) administered for 2 h twice daily for 3 days significantly reduced the pulmonary titer of RSV-infected mice. It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. Furthermore, the RD3-0028 aerosol administration appeared to protect the lungs of infected, CYP-treated mice against tissue damage, as evidenced by the preservation of the lung architecture and a reduction in pulmonary inflammatory infiltrates. RD3-0028 aerosol was not toxic for mice at the therapeutic dose. The present study demonstrates the effectiveness of aerosol administration of RD3-0028 for RSV-infected mice. (+info)

A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgA. (6/1481)

The standard method for collection of respiratory secretions, by use of a nasal wash (NW) to measure virus-specific IgA, is problematic in frail elderly adults. Therefore, a simplified collection approach using a nasal swab (NS) is described. NW and NS samples were collected from healthy young and frail elderly adults, and IgA titers to respiratory syncytial virus (RSV) fusion and attachment glycoproteins were determined by enzyme immunoassay. Correlation between IgA titers in NW and NS was excellent for each of the antigens (correlation coefficients,.71-.93). In addition, NS results were reproducible when frail elderly subjects were sampled several weeks apart and were nearly equivalent to results from NW samples. The ability to sample nasal secretions by use of an NS when an NW is not technically feasible will facilitate the study of mucosal immunity to RSV as well as the study of mucosal response to candidate RSV vaccines in frail elderly populations. (+info)

Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. (7/1481)

To determine the role of surfactant protein-A(SP-A) in antiviral host defense, mice lacking SP-A (SP-A-/-) were produced by targeted gene inactivation. SP-A-/- and control mice (SP-A+/+) were infected with respiratory syncytial virus (RSV) by intratracheal instillation. Pulmonary infiltration after infection was more severe in SP-A-/- than in SP-A+/+ mice and was associated with increased RSV plaque-forming units in lung homogenates. Pulmonary infiltration with polymorphonuclear leukocytes was greater in the SP-A-/- mice. Levels of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-6 were enhanced in lungs of SP-A-/- mice. After RSV infection, superoxide and hydrogen peroxide generation was deficient in macrophages from SP-A-/- mice, demonstrating a critical role of SP-A in oxidant production associated with RSV infection. Coadministration of RSV with exogenous SP-A reduced viral titers and inflammatory cells in the lung of SP-A-/- mice. These findings demonstrate that SP-A plays an important host defense role against RSV in vivo. (+info)

Induction of CD95 (Fas) and apoptosis in respiratory epithelial cell cultures following respiratory syncytial virus infection. (8/1481)

Respiratory syncytial virus (RSV) infection is associated with epithelial cell death and vigorous inflammation. In mouse models, and in immunosuppressed patients, CD8(+) T cells are necessary for RSV clearance. In vitro, RSV has been shown to induce expression of several proteins on the respiratory epithelial cell, including RSV proteins, ICAM-1, and MHC class I, that can potentially interact with CD8(+) T cells in initiating apoptosis of the target cell. One mechanism of T-cell-directed cell death is the interaction of FasL on the CD8(+) T lymphocytes and Fas expressed on the target cell. In order to determine the ability of RSV to induce Fas on the respiratory epithelium, we studied the RSV infection of a human respiratory epithelial cell line (A549) in vitro. Fas mRNA and protein levels are increased two-to-fourfold following RSV infection, and transcriptional upregulation of Fas was demonstrated using promoter/reporter gene constructs. RSV infection directly resulted in cellular apoptosis, and the frequency of apoptotic cells was further increased by cross-linking with antibodies to Fas. These data demonstrate that RSV infection induces cellular apoptosis and suggest that interactions of surface Fas with T cells may further augment this process in vivo. (+info)

... (RSV), also called human respiratory syncytial virus (hRSV) and human orthopneumovirus, is a common ... This is synonymous with Human respiratory syncytial virus (hRSV), which is often shortened to just RSV. It belongs to the genus ... contagious virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. Its name ... This sloughing mechanism is also thought to be responsible for the spread of virus from the upper to lower respiratory tract. ...

https://en.wikipedia.org/wiki/Respiratory_syncytial_virus

A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. As of ... October 2018). "The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates" (PDF). ... In August 2021, Moderna received US FDA fast track designation for their Respiratory Syncytial Virus Vaccine. As of October 10 ... Dudas, RA; Karron, RA (July 1998). "Respiratory syncytial virus vaccines". Clinical Microbiology Reviews. 11 (3): 430-439. doi: ...

https://en.wikipedia.org/wiki/Respiratory_syncytial_virus_vaccine

... (BRSV) is pneumovirus closely related to human respiratory syncytial virus (RSV) that is a ... "Bovine respiratory syncytial virus infection enhances Pasteurella multocida adherence on respiratory epithelial cells". ... "Review on bovine respiratory syncytial virus and bovine parainfluenza - usual suspects in bovine respiratory disease - a ... Larsen, L. E. (2000-03-01). "Bovine Respiratory Syncytial Virus (BRSV): A review". Acta Veterinaria Scandinavica. 41 (1): 1-24 ...

https://en.wikipedia.org/wiki/Bovine_respiratory_syncytial_virus

... is a protein produced by respiratory syncytial virus. Some features of the G protein ... "Functional Features of the Respiratory Syncytial Virus G Protein". Viruses. 13 (7). doi:10.3390/v13071214. PMC 8310105. PMID ... Li XQ, Fu ZF, Alvarez R, Henderson C, Tripp RA (January 2006). "Respiratory syncytial virus (RSV) infects neuronal cells and ... Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, Tripp RA (February 2006). "Respiratory syncytial virus G protein and ...

https://en.wikipedia.org/wiki/Respiratory_syncytial_virus_G_protein

"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review ... respiratory syncytial virus and influenza vaccines. She has worked extensively with American Indian populations and in Africa ... as an Epidemiologic Intelligence Officer in the Bacterial Respiratory Diseases Branch. In 1996, as part of her job at the CDC, ...

https://en.wikipedia.org/wiki/Katherine_O'Brien

Building on discoveries that Prince made as a doctoral student, VSI pioneered the prevention of respiratory syncytial virus ( ... Gregory A. Prince; Amy Mathews; Spencer J. Curtis; David D. Porter (2000). "Treatment of Respiratory Syncytial Virus ... Marina S. Boukhvalova; Gregory A. Prince; Jorge C. G. Blanco (2007). "Respiratory Syncytial Virus Infects and Abortively ... Linda G. Byrd; Gregory A. Prince (December 1997). "Animal Models of Respiratory Syncytial Virus Infection". Clinical Infectious ...

https://en.wikipedia.org/wiki/Gregory_Prince

The company stated that it would no longer develop Motavizumab for the prevention of respiratory syncytial virus (RSV), and as ... It is being investigated by MedImmune (today a subsidiary of AstraZeneca) for the prevention of respiratory syncytial virus ... "Pharmacological management of human respiratory syncytial virus infection". Expert Opinion on Pharmacotherapy. 21 (18): 2293- ...

https://en.wikipedia.org/wiki/Motavizumab

... human respiratory syncytial virus •Bos primigenius: bovine respiratory syncytial virus •Rodentia: murine pneumonia virus Mild ... Human respiratory syncytial virus (HRSV) is the most known orthopneumovirus because of its direct correlation and importance in ... "Respiratory Syncytial Virus Infection (RSV)". Center for Disease Control and Prevention. Retrieved 2019-06-03. "Disease ... ISBN 978-0-88167-552-8. Collins, Peter L. (1991). "The Molecular Biology of Human Respiratory Syncytial Virus (RSV) of the ...

https://en.wikipedia.org/wiki/Orthopneumovirus

2009 Human Metapneumovirus and Respiratory Syncytial Virus Disease in Children, Yemen - Sept. 2006 Respiratory Syncytial Virus ... Najla Al-Sonboli et al., "Respiratory Syncytial Virus and Human Metapneumovirus in Children with Acute Respiratory Infections ... Najla Al-Sonboli et al., "Human Metapneumovirus and Respiratory Syncytial Virus Disease in Children, Yemen - Volume 12, Number ... Tripp, Ralph A. (2010-03-15), "Pneumovirus and Metapneumovirus: Respiratory Syncytial Virus and Human Metapneumovirus", Topley ...

https://en.wikipedia.org/wiki/Najla_Al-Sonboli

Mumps virus (Paramyxoviridae) Human respiratory syncytial virus (Paramyxoviridae) Parainfluenza (Paramyxoviridae) Rabies ( ... ssRNA viruses include the Ebola virus, hantaviruses, influenza viruses, the Lassa fever virus, and the rabies virus. ... Human-specific −ssRNA viruses include the measles virus and the mumps virus. Many diseases caused by −ssRNA viruses have been ... Negative-strand RNA viruses (−ssRNA viruses) are a group of related viruses that have negative-sense, single-stranded genomes ...

https://en.wikipedia.org/wiki/Negative-strand_RNA_virus

Historical instances of the phenomenon were seen in vaccine candidates for respiratory syncytial virus, SARS-CoV, Middle East ... "Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease". Clinical and Vaccine Immunology. 23 (3): ... Vaccine-associated enhanced respiratory disease (VAERD), or simply enhanced respiratory disease (ERD), refers to an adverse ... inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus". ...

https://en.wikipedia.org/wiki/Vaccine-associated_enhanced_respiratory_disease

Typical viruses include respiratory syncytial virus, rhinovirus, influenza, and others. Bacteria are uncommon pathogens but may ... These viruses may be spread through the air when people cough or by direct contact. Risk factors include exposure to tobacco ... Upper respiratory tract infections often precede acute bronchitis, with overlapping symptoms including headache, nasal ... At least one other lower respiratory tract symptom, such as sputum production, wheezing, chest pain. No alternative explanation ...

https://en.wikipedia.org/wiki/Acute_bronchitis

Caballero MT, Polack FP (May 2018). "Respiratory syncytial virus is an "opportunistic" killer". Pediatric Pulmonology. 53 (5): ... Cytomegalovirus is a family of opportunistic viruses, most frequently associated with respiratory infection. Human polyomavirus ... Opportunistic infections caused by feline leukemia virus and feline immunodeficiency virus retroviral infections can be treated ... HIV is a virus that targets T cells of the immune system and, as a result, HIV infection can lead to progressively worsening ...

https://en.wikipedia.org/wiki/Opportunistic_infection

Cases of respiratory syncytial virus (RSV) in India mainly occur in North India in the winter. This virus causes lower ... Broor, S; Parveen, S; Maheshwari, M (2018). "Respiratory syncytial virus infections in India: Epidemiology and need for vaccine ... respiratory tract infection. India, like many other countries, uses the World Health Organization system for reporting and ...

https://en.wikipedia.org/wiki/Vaccination_in_India

"Structural characterization of the human respiratory syncytial virus fusion protein core". Proceedings of the National Academy ...

https://en.wikipedia.org/wiki/Mona_Singh_(scientist)

This is most commonly caused by respiratory syncytial virus (RSV, also known as human pneumovirus). Other agents that cause ... Acute bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% ... Carbonell-Estrany X, Figueras-Aloy J (2004). "Identifying risk factors for severe respiratory syncytial virus among infants ... Anderson, Larry J.; Graham, Barney S. (2013). Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Current ...

https://en.wikipedia.org/wiki/Bronchiolitis

HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One ... "Glycosaminoglycan sulfation requirements for respiratory syncytial virus infection". Journal of Virology. 74 (22): 10508-13. ... October 1999). "A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry". Cell. 99 (1): 13-22. doi: ... and those that generate a herpes simplex virus 1 glycoprotein D (HSV-1 gD) binding site (HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST4, ...

https://en.wikipedia.org/wiki/Heparan_sulfate

27 January 2019). Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Springer-Verlag. ISBN 9783642389184. ... especially Respiratory Syncytial Virus (RSV), an important cause of morbidity and mortality in young children and the elderly ... and chief of the Respiratory and Enteric Viruses Branch of the CDC Division of Viral and Rickettsial Diseases (1982-2006). From ... He was director of the Division of Viral Diseases in the National Center for Immunization and Respiratory Diseases at the CDC ( ...

https://en.wikipedia.org/wiki/Larry_J._Anderson

... at the cell surface is the receptor for the Respiratory Syncytial Virus (RSV) fusion protein. Interference with the ... Shakeri A, Mastrangelo P, Griffin JK, Moraes TJ, Hegele RG (Nov 2014). "Respiratory syncytial virus receptor expression in the ... Bilawchuk LM, Griffiths CD, Jensen LD, Elawar F, Marchant DJ (Aug 2017). "The Susceptibilities of Respiratory Syncytial Virus ... "Identification of nucleolin as a cellular receptor for human respiratory syncytial virus". Nature Medicine. 17 (9): 1132-5. doi ...

https://en.wikipedia.org/wiki/Nucleolin

"Regeneron to Discontinue Development of Suptavumab for Respiratory Syncytial Virus" (Press release). Regeneron. August 14, 2017 ... antibody designed for the prevention of medically attended lower respiratory tract disease due to respiratory syncytial virus. ...

https://en.wikipedia.org/wiki/Suptavumab

He was nearly killed by human respiratory syncytial virus at three months old. He was adopted by his stepfather, Wayne, at 13 ...

https://en.wikipedia.org/wiki/Addison_Russell

August 2018). "Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses ... In experiments in animals favipiravir has shown activity against West Nile virus, yellow fever virus, foot-and-mouth disease ... Nipah virus is a causative agent of outbreaks of encephalitis with pneumonia and has a high case fatality rate. The first ... "Korona virus: Koji se lekovi protiv Kovida-19 koriste u Srbiji". 22 November 2021. "EVA Pharma Announces Availability of ...

https://en.wikipedia.org/wiki/Favipiravir

"Passive immunisation against respiratory syncytial virus: a cost-effectiveness analysis". Archives of Disease in Childhood. 95 ... Microantibodies can stop viruses such as HIV from infecting cells in vitro. Antibodies are produced naturally by the body and ... virus-neutralizing microantibody". The Journal of General Virology. 86 (Pt 6): 1791-800. doi:10.1099/vir.0.80812-0. PMID ... which includes the production of antibodies that destroy infectious agents such as bacteria and viruses. Some infections can be ...

https://en.wikipedia.org/wiki/Microantibody

... is a humanized monoclonal antibody against respiratory syncytial virus. "WHO Drug Information" (PDF). Archived from ...

https://en.wikipedia.org/wiki/Felvizumab

Developed Monoclonal antibodies against JE, Dengue, WN, Chikungunya, Influenza and respiratory syncytial viruses (RSV). ... viruses First visualization of Hepatitis E virus particles, confirmation of the virus as the causative agent of water bore ... Invaluable collection of sera and virus strains: Approx. 260,000 serum samples and >600 strains of viruses isolated from humans ... Influenza and related viruses, Clinical virology, Biochemistry, Virus registry, and Biostatistics. The research activities of ...

https://en.wikipedia.org/wiki/National_Institute_of_Virology

In pregnant women, he studied the effectiveness of influenza and respiratory syncytial virus vaccines. He led one of the ... the influenza and respiratory syncytial virus vaccines. Since the global COVID-19 pandemic in 2020, he has been leading COVID- ... "Respiratory and Meningeal Pathogens Reaearch Unit". www.rmpru.com. Archived from the original on 8 February 2021. Retrieved 8 ... Madhi is professor of vaccinology and director of the South African Medical Research Council Respiratory and Meningeal ...

https://en.wikipedia.org/wiki/Shabir_Madhi

Respiratory tract infections are associated with member viruses such as human respiratory syncytial virus. There are five ... Viruses in this family are often associated with respiratory infections, and are transmitted through respiratory secretions. N ... proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein". Journal ... "Overexpression of the M2-2 Protein of Respiratory Syncytial Virus Inhibits Viral Replication". Journal of Virology. 79 (22): ...

https://en.wikipedia.org/wiki/Pneumoviridae

Yamada, Yumi; Yoshihara, Shigemi (2010). "Creola Bodies in Infancy with Respiratory Syncytial Virus Bronchiolitis Predict the ... These results were in keeping with the hypothesis that eosinophils cause desquamation of respiratory epithelial cells resulting ...

https://en.wikipedia.org/wiki/Creola_bodies

Wang, KC; Chang, JS; Chiang, LC; Lin, CC (2009). "4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a ...

https://en.wikipedia.org/wiki/4-Methoxycinnamaldehyde

"Increased concordance of severe respiratory syncytial virus infection in identical twins". Pediatrics. 121 (3): 493-6. doi: ...

https://en.wikipedia.org/wiki/Concordance_(genetics)

... his group is known for working on developing vaccines against respiratory syncytial virus, parainfluenza virus, influenza virus ... Respiratory syncytial virus and other pneumoviruses: a review of the international symposium-RSV 2003, Virus Research 106 (2004 ... 1331-1342 Collins PL, Hill MG... Murphy BR (1995). Production of infectious human respiratory syncytial virus from cloned cDNA ... Chanock award for lifetime achievements in RSV research at the Respiratory Syncytial Virus 2003 symposium in November 2003. He ...

https://en.wikipedia.org/wiki/Brian_R._Murphy

... has also worked with researchers at SickKids to study the development of asthma following severe respiratory syncytial virus ...

https://en.wikipedia.org/wiki/Shelley_Deeks

These viruses include hepatitis C virus, HIV-1, influenza A virus, poliovirus, respiratory syncytial virus, and SARS-CoV. ... They are found in a variety of viral genomes but are particularly common in RNA viruses. Many viruses that cause human disease ... Carrasco L (August 1995). "Modification of membrane permeability by animal viruses". Advances in Virus Research. 45: 61-112. ... Influenza and Other Respiratory Viruses. 1 (1): 27-34. doi:10.1111/j.1750-2659.2006.00006.x. PMC 4634659. PMID 19453477. Oxford ...

https://en.wikipedia.org/wiki/Viroporin

Studying ways of preventing or treating diseases caused by respiratory syncytial virus (RSV), herpes simplex virus, and dengue ... Developing vaccine strategies for Ebola, HIV, Lassa virus, West Nile virus, Japanese encephalitis viruses, and herpes. ... Developing an animal model to test vaccines to protect people against the Zika virus. On April 14, 2018, four baboons escaped ... Helped advance a new treatment which moved from animal to human trials for chronic hepatitis B virus (HBV) infection. ...

https://en.wikipedia.org/wiki/Texas_Biomedical_Research_Institute

... joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and ... At the NIH, Corbett worked on the pathogenesis of respiratory syncytial virus as well as on a project focused on innovative ... Recognizing that the virus was similar to severe acute respiratory syndrome coronavirus, Corbett's team utilized previous ... Her early research considered the development of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome ...

https://en.wikipedia.org/wiki/Kizzmekia_Corbett

... respiratory syncytial virus (RSV), spinal fluid leak, and tobacco smoke. Rhinorrhea is especially common in cold weather. Cold- ... soldier in the fight against respiratory viruses". Clin. Microbiol. Rev. 24 (1): 210-29. doi:10.1128/CMR.00014-10. PMC 3021210 ... This is to prevent infection from spreading to the lungs and respiratory tract, where it could cause far worse damage. It has ... also been suggested that rhinorrhea is a result of viral evolution whereby virus variants that increase nasal secretion are ...

https://en.wikipedia.org/wiki/Rhinorrhea

"Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis". BMC Infectious Diseases. 6: 175. doi: ...

https://en.wikipedia.org/wiki/IFI27

Known viral causes of atypical pneumonia include respiratory syncytial virus (RSV), influenza A and B, parainfluenza, ... adenovirus, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), COVID-19 and measles. Chest ... "Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak". Archived from the original on 7 December 2008. Retrieved ... Despite general symptoms and problems with the upper respiratory tract (such as high fever, headache, a dry irritating cough ...

https://en.wikipedia.org/wiki/Atypical_pneumonia

2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls ... 2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway ...

https://en.wikipedia.org/wiki/CCL8

In children, influenza is one of the two most common causes of ARDS, the other being the respiratory syncytial virus. About 3-5 ... that contain weakened viruses. There are three types of inactivated vaccines: whole virus, split virus, in which the virus is ... Influenza B virus (IBV) and Influenza C virus (ICV) primarily infect humans, and Influenza D virus (IDV) is found in cattle and ... Influenza viruses that infect the upper respiratory tract like H1N1 tend to be more mild but more transmissible, whereas those ...

https://en.wikipedia.org/wiki/Influenza

... and respiratory syncytial virus. Tedizolid was approved by the US Food and Drug Administration on June 20, 2014. Mullin, Emily ...

https://en.wikipedia.org/wiki/Cubist_Pharmaceuticals

... leading to the design of a better vaccine against respiratory syncytial virus. Graham is married to Cynthia Turner-Graham, also ... He was a member of the research team that designed a spike protein to combat the virus. His research found that some virus ... but he insisted on maintaining a research laboratory to focus on vaccines for three categories of respiratory viruses. During ... collaborated to create a vaccine intended to prevent the Zika virus. Moving from inception to manufacturing in just three ...

https://en.wikipedia.org/wiki/Barney_S._Graham

Respiratory Syncytial Virus (RSV), and SARS-CoV-2. On 30 October, it was reported that worldwide 424 deaths occurred due to the ... The first northern hemisphere autumn after the relaxation of US public health measures led to a surge in respiratory viruses ... On 23 November, it was reported that the second wave of the virus had led some hospitals to stop accepting patients. The virus ... the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 ...

https://en.wikipedia.org/wiki/COVID-19_pandemic

... intended for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in newborns and infants. ... Nirsevimab is being investigated as an experimental vaccine against respiratory syncytial virus, RSV, in the general infant ... "New medicine to protect babies and infants from respiratory syncytial virus (RSV) infection". European Medicines Agency (EMA) ( ... "Nirsevimab demonstrated protection against respiratory syncytial virus disease in healthy infants in Phase 3 trial" (Press ...

https://en.wikipedia.org/wiki/Nirsevimab

... and precise viral quantitation demonstrates children co-infected with rhinovirus and respiratory syncytial virus, ... Recombination in RNA viruses appears to be an adaptive mechanism for transmitting an undamaged genome to virus progeny. ... An example is the coinfection of liver cells with hepatitis B virus and hepatitis D virus, which can arise incrementally by ... Virus Res. 2019;265:43-46. doi:10.1016/j.virusres.2019.03.003 Drake JW (August 1958). "Interference and multiplicity ...

https://en.wikipedia.org/wiki/Coinfection

Bartz H, Büning-Pfaue F, Türkel O, Schauer U (September 2002). "Respiratory syncytial virus induces prostaglandin E2, IL-10 and ...

https://en.wikipedia.org/wiki/Interleukin_11

... hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV), human immunodeficiency virus (HIV), respiratory syncytial ... Benzethonium chloride exhibits a broad spectrum of microbiocidal activity against bacteria, fungi, mold and viruses. ... virus (RSV), and norovirus.[citation needed] The US Food and Drug Administration (FDA) specifies that the safe and effective ...

https://en.wikipedia.org/wiki/Benzethonium_chloride

HSV Influenza virus Human immunodeficiency virus, HIV Respiratory syncytial virus, RSV Yeasts and moulds Aspergillus niger ... Mikola H, Waris M, Tenovuo J (Mar 1995). "Inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus ... Respiratory tract antimicrobial defense system Furtmüller PG, Zederbauer M, Jantschko W, Helm J, Bogner M, Jakopitsch C, ... Streptococcus mutans Wolinella recta Xanthomonas campestris Yersinia enterocolitica Viruses Echovirus 11 Herpes simplex virus, ...

https://en.wikipedia.org/wiki/Hypothiocyanite

... (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human ... "Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in ... a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection". Journal of Medicinal ... Brendish NJ, Clark TW (December 2017). "Antiviral treatment of severe non-influenza respiratory virus infection". Current ...

https://en.wikipedia.org/wiki/Lumicitabine

... other viruses such as respiratory syncytial virus, parainfluenza virus and adenoviruses can cause them too. Rhinoviruses also ... Nitazoxanide also inhibits the replication of a broad range of other RNA and DNA viruses including respiratory syncytial virus ... A monoclonal drug is now being sold to help fight respiratory syncytial virus in babies, and antibodies purified from infected ... Nokes JD, Cane PA (December 2008). "New strategies for control of respiratory syncytial virus infection". Curr. Opin. Infect. ...

https://en.wikipedia.org/wiki/Antiviral_drug

"Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children". The Cochrane ... The aerosol form has been used in the past to treat respiratory syncytial virus-related diseases in children, although the ... Such hypermutation can be lethal to RNA viruses. Neither of these mechanisms explains ribavirin's effect on many DNA viruses, ... B virus on antiviral treatment with interferon and ribavirin in Asian patients with hepatitis C virus/hepatitis B virus ...

https://en.wikipedia.org/wiki/Ribavirin

... the medicine has been found to be effective against respiratory syncytial virus and influenza virus. Padheyam, a program to ...

https://en.wikipedia.org/wiki/Pankajakasthuri_Herbals

It is the second most common cause after Respiratory syncytial virus (RSV) of lower respiratory infection in young children.[ ... "Rates of Hospitalizations for Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza Virus in Older Adults". The ... Widmer, Kyle; Griffin, Marie R.; Zhu, Yuwei; Williams, John V.; Talbot, H. Keipp (2014-05-01). "Respiratory syncytial virus- ... "Seroepidemiologies of Human Metapneumovirus and Respiratory Syncytial Virus in Young Children, Determined with a New ...

https://en.wikipedia.org/wiki/Human_metapneumovirus

Sendai virus was also used as a backbone for vaccine against respiratory syncytial virus (HRSV). This virus (HRSV), is a major ... Sendai virus also used as a backbone for vaccine against respiratory syncytial virus (RSV). For cancer studies, it is desirable ... May 2015). "Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein ... The latter include Human Respiratory Syncytial Virus (HRSV), Human Metapneumovirus (HMPV) and Human Parainfluenza Viruses (HPIV ...

https://en.wikipedia.org/wiki/Murine_respirovirus

... respiratory syncytial virus, as well as strains of alpha-coronavirus NL-63 and beta-coronavirus SARS-CoV-2, etc. In vitro ... Enisamium iodide effectively inhibited SARS-CoV-2 virus replication in vitro in Caco-2 cells. Enisamium has antiviral activity ... Amizon tablets are indicated for the treatment and prevention of influenza and acute respiratory viral infections. Amizon Max ... March 2021). "Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase ...

https://en.wikipedia.org/wiki/Enisamium_iodide

... virus, or RSV, is a respiratory virus that infects the lungs and breathing passages. Learn how to prevent it. ... Source: National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases ... This may help prevent infection and spread of the virus during the RSV season ...

https://www.cdc.gov/rsv/about/prevention.html

Respiratory Syncytial Virus (RSV) causes cold-like symptoms in adults and healthy children, but can cause serious problems in ... What is respiratory syncytial virus (RSV)?. Respiratory syncytial virus, or RSV, is a common respiratory virus. It usually ... Respiratory Syncytial Virus (Nemours Foundation) Also in Spanish * Respiratory Syncytial Virus (RSV) (National Institute of ... Respiratory Syncytial Virus (RSV) (March of Dimes Foundation) Also in Spanish * Respiratory Syncytial Virus Infection (RSV) in ...

https://medlineplus.gov/respiratorysyncytialvirusinfections.html

... is the leading cause of lower respiratory tract infections (LRTIs) in infants and young children.{file44441}The clinical entity ... Infection with respiratory syncytial virus (RSV; see the image below), which manifests primarily as bronchiolitis or viral ... encoded search term (Respiratory Syncytial Virus Infection) and Respiratory Syncytial Virus Infection What to Read Next on ... Fast Five Quiz: Overview of Pediatric Respiratory Syncytial Virus * Fast Five Quiz: Pediatric Respiratory Syncytial Virus ...

https://www.medscape.com/answers/971488-178145/what-are-the-differential-diagnoses-for-respiratory-syncytial-virus-infection

Generic protocol to examine the incidence of lower respiratory infection due to respiratory syncytial virus in children less ... Respiratory syncytial virus [‎RSV]‎ is a leading cause of mortality and morbidity in young infants, little was known on its ... WHO preferred product characteristics for respiratory syncytial virus (‎RSV)‎ vaccines World Health Organization (‎World ... Circulation of Respiratory Syncytial Virus in Morocco during 2014-2016: Findings from a sentinel-based virological surveillance ...

https://extranet.who.int/iris/restricted/browse?authority=Respiratory+Syncytial+Viruses&type=mesh

... to develop a new respiratory syncytial virus (RSV) challenge strain ... RSV is recognised as a significant cause of respiratory illness in all age groups. It is highly infectious and the most common ... SGSs experience in both virus development and in conducting human challenge trials safely and to exacting standards provides ... cause of lower respiratory tract infections in paediatric populations worldwide, resulting in a high number of hospitalisations ...

https://manufacturingchemist.com/news/article_page/Development_of_new_respiratory_syncytial_virus_vaccine/134892

Respiratory syncytial virus (RSV), a common cause of winter outbreaks of acute respiratory disease, results in an estimated ... Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. ... An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines ... Respiratory syncytial virus infection in the elderly. Eur J Clin Microbiol Infect Dis 1996;15:777-81. * Whimbey E, Couch RB, ...

https://wonder.cdc.gov/wonder/prevguid/m0050267/m0050267.asp

A: Respiratory syncytial virus is a seasonal respiratory virus that usually causes mild, cold-like symptoms. Most people ... often caused by respiratory syncytial virus or RSV.. We asked UCSF Benioff Childrens Hospitals experts Steven Bin, M.D., ... Direct contact with the virus, like kissing the face of a child with RSV, also spreads the virus. ... date vaccinations for COVID-19 and influenza will help protect you and your family from this and other respiratory viruses. ...

https://universityofcalifornia.edu/news/what-respiratory-syncytial-virus-rsv

Infection Clinical Research Trial Listings in Pediatrics/Neonatology Pulmonary/Respiratory Diseases Family Medicine Infections ... Respiratory Syncytial Virus (RSV) Infection Clinical Trials. A listing of Respiratory Syncytial Virus (RSV) Infection medical ... Also, To better understand the burden of other respiratory viruses such as respiratory syncytial virus (RSV) and SARS-CoV-2 in ... in Preventing Hospitalizations Due to Respiratory Syncytial Virus in Infants (HARMONIE) (VAS00006) lower respiratory tract ...

https://www.centerwatch.com/clinical-trials/listings/condition/640/respiratory-syncytial-virus-rsv-infection/?dt_type=updated

... one of the most common causes of respiratory infections in immunocompetent individuals, can cause significant pulmonary ... Respiratory syncytial virus (RSV), one of the most common causes of respiratory infections in immunocompetent individuals, can ... Respiratory Syncytial Virus in Hematopoietic Stem Cell Transplantation and Solid-Organ Transplantation Curr Infect Dis Rep. ... Early diagnosis and medical intervention prior to the progression from upper to lower respiratory tract viral involvement is ...

https://pubmed.ncbi.nlm.nih.gov/26068871/

Respiratory syncytial virus (RSV) is a significant cause of respiratory tract infection in infants, young children, and older ... Fast Five Quiz: Pediatric Respiratory Syncytial Virus Management - Medscape - Mar 03, 2022. ...

http://reference.medscape.com/viewarticle/967068

MultiCare Health System is looking for older adults in Spokane to participate in a global vaccine trial for a respiratory virus ... MultiCare Health System is looking for older adults in Spokane to participate in a global vaccine trial for a respiratory virus ... Respiratory syncytial virus most often affects young children and older people, especially those with other health issues. Each ... Volunteers wanted for vaccine trial to prevent respiratory syncytial virus. Sept. 29, 2022 Updated Thu., Sept. 29, 2022 at 9:21 ...

https://www.spokesman.com/stories/2022/sep/29/volunteers-wanted-for-vaccine-trial-to-prevent-res/

... is a highly contagious respiratory virus that can cause serious illness in children and adults. It is important to know the ... is a highly contagious respiratory virus that can cause serious illness in children and adults. It is important to know the ... Respiratory syncytial virus (RSV) is a common virus that affects the human respiratory system. ... While there is no vaccine currently available for respiratory syncytial virus (RSV), Riverside encourages every eligible person ...

https://www.riversideonline.com/patients-and-visitors/healthy-you-blog/blog/r/respiratory-syncytial-virus

... a viral respiratory illness that usually causes mild, cold-like symptoms. ... Find more information about respiratory syncytial virus, or RSV, ... Respiratory Syncytial Virus (RSV) Doctors and health systems ... throughout the country are seeing an uptick in cases of respiratory syncytial virus, or RSV, a viral respiratory illness that ... Get vaccinated against respiratory illnesses, including the flu. Visit www.vaccines.gov to search for vaccine availability or ...

http://www.berriencounty.org/1875/Respiratory-Syncytial-Virus-RSV

All the latest science news about respiratory syncytial virus from Phys.org ... Human respiratory syncytial virus. Human respiratory syncytial virus (RSV) causes respiratory tract infections. It is the major ... RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, which includes common respiratory viruses ... Its name comes from the fact that F proteins on the surface of the virus cause the cell membranes on nearby cells to merge, ...

https://phys.org/tags/respiratory+syncytial+virus/sort/popular/1m/

US-5824307-A chemical patent summary.

https://pubchem.ncbi.nlm.nih.gov/patent/US-5824307-A

The presence of lower respiratory tract infection and infection in the pre-engraftment phase of BMT is believed to confer a ... infection is an important cause of respiratory mortality in immunosuppressed patients, including bone marrow transplant (BMT) ... Respiratory syncytial virus (RSV) infection is an important cause of respiratory mortality in immunosuppressed patients, ... Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination ...

https://www.nature.com/articles/1703046?error=cookies_not_supported&code=ab4a9259-195c-40dc-a9c7-72beaa08cd18

Browse our Human Respiratory Syncytial Virus Nucleoprotein VPN41 Antibodies all backed by our Guarantee+. ... Human Respiratory Syncytial Virus Nucleoprotein VPN41 Antibodies available through Novus Biologicals. ... Human Respiratory Syncytial Virus Nucleoprotein VPN41 Antibody (4-18) [Alexa Fluor® 488] ... 1 Results for "human-respiratory-syncytial-virus-nucleoprotein-vpn41" in Primary Antibodies ...

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Experiencing a serious bout of Respiratory Syncytial Virus (RSV) can be traumatizing, especially with a very young baby who ... For most of us, RSV (Respiratory Syncytial Virus) just looks like a bad cold. But for babies and young children, it can result ... But alas, Adam came down with the virus. His symptoms were like those of a typical cold at the beginning, Ireland recalls. But ... What Ireland remembers more than anything is that she was not warned about how serious things could get with a virus like RSV ...

https://www.scarymommy.com/espiratory-syncytial-virus-rsv

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of ...

https://www.merck.com/publication/upper-and-lower-respiratory-tract-correlates-of-protection-against-respiratory-syncytial-virus-following-vaccination-of-nonhuman-primates/

... is a common virus that can cause infections in the nose, throat, lungs and respiratory tract. ... Respiratory syncytial virus (RSV) is a common virus that can cause infections in the nose, throat, lungs and respiratory tract ... I actually heard someone the other day say its not respiratory syncytial virus. Its repetitive suctioning virus because you ... At The Forefront: RSV, COVID and other respiratory illnesses. Respiratory viruses are surging throughout the area and parents ...

https://www.uchicagomedicine.org/comer/conditions-services/infectious-diseases/rsv

Respiratory Syncytial Virus (RSV) in children can become severe in just a few days. See its signs and symptoms and how you can ... What Is Respiratory Syncytial Virus (RSV) in Children?. About 58,000 children younger than 5 years old are hospitalized because ... of the respiratory syncytial virus (RSV) annually in the United States. While this respiratory virus often causes mild, cold- ... We recommend that you follow the safety precautions to help keep your child from catching the virus and to see a pediatrician ...

https://www.stmarysmc.com/healthy-living/corporate-content/what-is-respiratory-syncytial-virus-rsv-in-children

https://www.westbocamedctr.com/healthy-living/corporate-content/what-is-respiratory-syncytial-virus-rsv-in-children

Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada)-dedicated to using leading-edge science to save and improve lives around the world. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge.. ...

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Three respiratory viruses - COVID-19, influenza and respiratory syncytial virus, or RSV - are currently circulating in the U.S ... for the respiratory syncytial virus," says Dr. Robert Jacobson, a Mayo Clinic pediatrician. "Its a nearly ubiquitous virus in ... Jacobson says respiratory syncytial virus can start a cycle of illness within a family. "It keeps coming back and the family ... For instance, people with cold like symptoms should avoid kissing babies at risk for respiratory syncytial virus. The Centers ...

https://newsnetwork.mayoclinic.org/discussion/infectious-diseases-a-z-break-the-cycle-of-respiratory-syncytial-virus/

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection ... The lung is a critical prophylaxis target for numerous infectious agents, including human respiratory syncytial virus (RSV) and ... Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection. by Pooja Munnilal Tiwari, Daryll Vanover, ...

https://www.bruker.com/zh/products-and-solutions/fluorescence-microscopy/fluorescence-microscopy-journal-club/pre-2020/engineered-mrna-expressed-antibodies-prevent-respiratory-syncyti.html

Respiratory Syncytial Virus: Reasons for Optimism About a Dreaded Childhood Disease * Azucena Bardají , Associate Research ... Respiratory Syncytial Virus: Reasons for Optimism About a Dreaded Childhood Disease. 23.11.2022 Photo: H4+ Sven Torfinn ... influenza and respiratory syncytial virus (RSV). This "tripledemic" has already overwhelmed hospital paediatric units in some ... RSV causes infections of the lungs and the respiratory tract. It is so common that most children become infected with the virus ...

https://www.isglobal.org/en/healthisglobal/-/custom-blog-portlet/virus-respiratorio-sincitial-razones-para-el-optimismo-en-una-temible-enfermedad-infantil/91163/0

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease in infants, young children and ... Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review ... Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years. Virus Res. 2011 Dec; ... Respiratory syncytial virus (RSV) is recognized to be the most important viral pathogen causing acute lower respiratory tract ...

https://www.emro.who.int/ar/emhj-volume-22-2016/volume-22-issue-7/circulation-of-respiratory-syncytial-virus-in-morocco-during-2014-2016-findings-from-a-sentinel-based-virological-surveillance-system-for-influenza.html

Another illness that is common from late fall through early spring is respiratory syncytial virus infection or RSV. ... The virus can spread from one person to another, and you can get it by touching unclean surfaces. Almost all children get RSV ...

https://publications.aap.org/aapnews/news/18683/Does-your-child-have-a-cold-or-respiratory?autologincheck=redirected?nfToken=00000000-0000-0000-0000-000000000000

RSV or Respiratory Syncytial Virus is a seasonal lung infection that mainly affects the lower respiratory tract of children and ... RSV or Respiratory Syncytial Virus is a seasonal lung infection that mainly affects the lower respiratory tract of children and ... Since RSV is a virus, antibiotic treatment is not possible. It is mostly seen as a mild infection and is treated on par with ... Children who are infected with the virus can be contagious for up to 3 to 8 days and in certain cases with kids who have weak ...

https://countyenews.com/respiratory-syncytial-virus-in-children/

Respiratory Syncytial Virus Infection (RSV): Trends and Surveillance. (medscape.com)
Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries. (medscape.com)
Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. (medscape.com)
Perez-Yarza EG, Moreno A, Lazaro P, Mejias A, Ramilo O. The association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature. (medscape.com)
Oray-Schrom P, Phoenix C, St Martin D, Amoateng-Adjepong Y. Sepsis workup in febrile infants 0-90 days of age with respiratory syncytial virus infection. (medscape.com)
Respiratory syncytial virus infection in elderly and high-risk adults. (medscape.com)
Homelessness has not previously been identified as a risk tions as the safety-net hospital for the Seattle metropolitan factor for respiratory syncytial virus (RSV) infection. (cdc.gov)
Only 10% (4/40) persons as an at-risk population for severe RSV disease of patients with RSV infection who were readmitted within might guide prioritization strategies for RSV vaccines 30 days had a positive swab specimen for the same virus at and therapeutics as they become available. (cdc.gov)
This virus remains active on surfaces longer than most, so it is important to wash your hands and disinfect surfaces regularly to reduce the spread of the infection. (universityofcalifornia.edu)
A listing of Respiratory Syncytial Virus (RSV) Infection medical research trials actively recruiting patient volunteers. (centerwatch.com)
Respiratory syncytial virus (RSV) is a significant cause of respiratory tract infection in infants, young children, and older or immunocompromised adults. (medscape.com)
However, for most infants, children and adults, there is no specific treatment for RSV infection, though researchers are working to develop vaccines and antivirals (medicines that fight viruses). (riversideonline.com)
It is the major cause of lower respiratory tract infection and hospital visits during infancy and childhood. (phys.org)
Respiratory syncytial virus (RSV) infection is an important cause of respiratory mortality in immunosuppressed patients, including bone marrow transplant (BMT) recipients. (nature.com)
The presence of lower respiratory tract infection and infection in the pre-engraftment phase of BMT is believed to confer a poor prognosis. (nature.com)
Similar to many other respiratory viruses, there is no specific treatment for managing the symptoms of an RSV infection. (uchicagomedicine.org)
The proportion of positive RSV infection was higher in patients hospitalized with acute respiratory infection compared to those with mild symptoms in out-patient clinics. (who.int)
La proportion d'infections positives au VRS était plus élevée chez les patients hospitalisés pour une infection respiratoire aiguë que chez les patients en consultation externe souffrant de légers symptômes. (who.int)
Does your child have a cold or respiratory syncytial virus infection? (aap.org)
Another illness that is common from late fall through early spring is respiratory syncytial virus infection or RSV. (aap.org)
RSV or Respiratory Syncytial Virus is a seasonal lung infection that mainly affects the lower respiratory tract of children and adults. (countyenews.com)
The incubation time for virus, i.e. time from infection until the symptoms arrive is generally between 4 to 5 days. (researchnester.com)
hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome. (microbiologyresearch.org)
Neutralizing antibodies seem to be a correlate of protection against severe disease, and cell-mediated immunity is thought to be essential for virus clearance following acute infection. (ugent.be)
15, 2017-RSV infection reduces the risk of infection with human rhinovirus, which could have implications for vaccine development and prevention strategies for viral respiratory tract infections in infants. (vumc.org)
However, if more vulnerable patients (e.g. preterm infants, ill infants or elderly people) are infected with the virus, they may develop a severe lower respiratory tract infection, such as bronchiolitis or pneumonia. (efcni.org)
During two animal infection experiments, swabs were collected from personnel (nasal mucosa) and their clothes, boots and equipment after contact with calves shedding either virus. (biomedcentral.com)
While Respiratory syncytial virus (or RSV), might result in a common and annoying cold for healthy adults and older children, this highly contagious lung infection can result in a severe respiratory illness that blocks the breathing airways in young children. (activebeat.com)
Researchers conducted a systematic literature review of studies published between January 2017 and December 2020 that reported estimates of morbidity and mortality among children younger than 5 years with RSV-associated acute lower respiratory infection (LRI). (infectiousdiseaseadvisor.com)
Zeng S, Wu J, Liu J, Qi F, Liu B.IL-33 Receptor (ST2) Signalling is Important for Regulation of Th2-Mediated Airway Inflammation in a Murine Model of Acute Respiratory Syncytial Virus Infection[J].Scand J Immunol, 2015, 81:494-501. (fudan.edu.cn)
Popow-Kraupp, T. and Aberle, J.H. (2011) Diagnosis of Respiratory Syncytial Virus Infection. (testtargettreat.com)
1999) Respiratory syncytial virus: an underestimated cause of respiratory infection, with prospects for a vaccine. (testtargettreat.com)
Evaluation of an acute point-of-care system screening for respiratory syncytial virus infection. (testtargettreat.com)
IMSEAR at SEARO: Respiratory syncytial virus infection in children in West Bengal. (who.int)
In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. (mdpi.com)
At first, the virus causes an infection in the upper respiratory tract. (ahealthyme.com)
A blood test may help see if the infection is caused by a virus or bacteria. (ahealthyme.com)
Pascal Soriot, Chief Executive Officer, said: "The long-acting antibody combination has the potential to offer almost immediate protection to those who are not able to be vaccinated, to both prevent infection or treat the disease in patients already infected with the virus. (cision.com)
1-4 The reduced Fc receptor binding aims to minimise the risk of antibody-dependent enhancement of disease - a phenomenon in which virus-specific antibodies promote, rather than inhibit, infection and/or disease. (cision.com)
What is the risk of serious bacterial infection (SBI) in febrile infants ≤60 days of age with influenza virus infections? (the-hospitalist.org)
Co-infection rates between the viruses ranged from 1% (hMPV and Adenovirus) to 12% (hMPV and Human Bocavirus). (pediatriceducation.org)
These symptoms are common to other respiratory viral infections but are highly suggestive of influenza virus infection when an outbreak is occurring in the community. (medscape.com)
2-7 Although SARS has not re-appeared, sporadic cases of human infection with avian influenza viruses continue to occur. (who.int)
8 Common non-influenza respiratory viruses are also important causes of significant acute respiratory infection in the country. (who.int)

Who is at risk for respiratory syncytial virus (RSV) infections? (medlineplus.gov)
What are the symptoms of respiratory syncytial virus (RSV) infections? (medlineplus.gov)
How are respiratory syncytial virus (RSV) infections diagnosed? (medlineplus.gov)
What are the treatments for respiratory syncytial virus (RSV) infections? (medlineplus.gov)
Can respiratory syncytial virus (RSV) infections be prevented? (medlineplus.gov)
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. (medscape.com)
It is highly infectious and the most common cause of lower respiratory tract infections in paediatric populations worldwide, resulting in a high number of hospitalisations. (manufacturingchemist.com)
Respiratory syncytial virus (RSV), one of the most common causes of respiratory infections in immunocompetent individuals, can cause significant pulmonary morbidity and mortality in hematopoietic stem cell (HSCT) and less often in solid-organ transplant recipients. (nih.gov)
Human respiratory syncytial virus (RSV) causes respiratory tract infections. (phys.org)
Respiratory syncytial virus (RSV) is a common virus that can cause infections in the nose, throat, lungs and respiratory tract. (uchicagomedicine.org)
RSV causes infections of the lungs and the respiratory tract. (isglobal.org)
We conducted a prospective study using sentinel-based influenza surveillance to detect RSV by real time PCR in patients with acute respiratory infections, enrolled during two seasons (2014/15, 2015/16). (who.int)
RSV remains important viral etiological agent causing influenza-like illness and severe acute respiratory infections especially among infants in Morocco. (who.int)
Additionally, increased incidences of respiratory infections and rising neonatal population are also among the major factors driving the growth of the market. (researchnester.com)
Respiratory syncytial virus is among the leading causes of lower respiratory tract infections in infants and young children. (researchnester.com)
RSV is the leading cause of lower respiratory tract infections in infants and children worldwide, with high morbidity and mortality rates. (labroots.com)
Respiratory Syncytial Virus is a virus that causes infections of the lungs and airways. (efcni.org)
Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. (emoryhealthsciblog.com)
found that lack of boot provision for visitors was a risk factor for infections with both viruses [ 12 ] and Toftaker et al. (biomedcentral.com)
Anti-interleukin-33 treatment limits acute exacerbation induced by respiratory syncytial virus[J]. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(1): 2-9. (fudan.edu.cn)
World Health Organization (WHO) Acute Respiratory Infections (Update September 2009). (testtargettreat.com)
Respiratory syncytial virus (RSV) (see the image below) is the leading cause of lower respiratory tract infections (LRTIs) in infants and young children. (medscape.com)
Takeuchi Y, Kikuchi T, Kimura M. Guillain-Barré syndrome associated with ECHO virus type 7 infections. (medscape.com)
Respiratory syncytial virus (RSV) causes more lower respiratory tract infections, often manifested as bronchiolitis, among young children than any other pathogen. (nih.gov)
Infections with influenza virus (H1N1), respiratory syncytial virus (RSV) or nontypeable Haemophilus influenzae (NTHi) are important triggers of exacerbations. (uni-wuerzburg.de)
Febrile infants with documented viral infections have a lower rate of SBI than febrile infants who do not have a positive test for a specific virus. (the-hospitalist.org)
The literature strongly supports this finding with respiratory syncytial virus (RSV), although the specific association with influenza is less clear, particularly as there is an increased risk of secondary bacterial infections in patients of all ages with influenza. (the-hospitalist.org)
Acute respiratory infections particularly clinical pneumonia are one of the most common causes of death world-wide. (pediatriceducation.org)
One study in Finland found ~15% (5% for each group) of rapid virus detection specimens had adenovirus, human metapneumovirus and human bocavirus (a Parvoviridae virus causing respiratory infections identified in 2005). (pediatriceducation.org)
Information on Respiratory Syncytial Virus Infections (RSV) has been updated. (phynetinc.com)
Acute viral respiratory infections are an important cause of morbidity and hospitalization in Viet Nam where social and demographic conditions appear to heighten the risk of outbreaks capable of causing widespread disease and mortality. (who.int)
In Viet Nam, human infections with avian influenza A(H5N1) virus have occurred since 2003 1 and cases of severe acute respiratory syndrome (SARS) occurred in 2004. (who.int)
A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. (bvsalud.org)

SGS's experience in both virus development and in conducting human challenge trials safely and to exacting standards provides the potential to gain efficacy data concerning the vaccine prior to initiating a phase III study. (manufacturingchemist.com)
MultiCare physician Dr. Jonathan Staben is enrolling local residents age 65 and older in a trial for a respiratory syncytial virus vaccine. (spokesman.com)
MultiCare Health System is looking for older adults in Spokane to participate in a global vaccine trial for a respiratory virus that currently has no approved vaccine or treatment. (spokesman.com)
While there is no vaccine currently available for respiratory syncytial virus (RSV), Riverside encourages every eligible person to receive vaccinations for both COVID-19 and the flu.For more information on receiving one or both of these vaccinations from Riverside, please visit riversideonline.com . (riversideonline.com)
There is no vaccine to protect against respiratory syncytial virus. (mayoclinic.org)
Oct. 20, 2016-Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it. (vumc.org)
Crafting a vaccine against RSV (respiratory syncytial virus) has been a minefield for 50 years, but scientists believe they have found the right balance. (emoryhealthsciblog.com)
Organoids generated from dozens of tissues and organs available commercially, or accessible through published protocols include patient-derived models of liver , heart, pancreas, brain, GI tract, kidney, and recently, of human airways suitable for drug and vaccine development and for studying infectious human respiratory diseases. (corning.com)
The investigational vaccine demonstrated an efficacy of 82.4% against RSV lower respiratory tract disease with three or more symptoms. (theperfectenemy.com)

Cases of RSV and other respiratory illnesses - such as enterovirus, rhinovirus and parainfluenza - are surging throughout the United States, placing many pediatric hospitals at full capacity. (uchicagomedicine.org)
Bovine Respiratory Syncytial virus (BRSV) and Bovine Parainfluenza 3 virus (BPIV3) are closely related viruses involved in and both important pathogens within bovine respiratory disease (BRD), a major cause of morbidity with economic losses in cattle populations around the world. (ugent.be)
B. Makoschey and A. C. Berge, "Review on bovine respiratory syncytial virus and bovine parainfluenza : usual suspects in bovine respiratory disease : a narrative review," BMC VETERINARY RESEARCH , vol. 17, no. 1, 2021. (ugent.be)
23, 2021-"We are seeing a spike in respiratory illnesses, especially RSV (respiratory syncytial virus) and parainfluenza, which cause croup and bronchiolitis in young children and flu-like symptoms in older children and adults," said James Antoon, MD, PhD, FAAP, assistant professor of Pediatrics at Children's Hospital at Vanderbilt. (vumc.org)
Common viral causes of pneumonia include Respiratory Syncytial virus, Influenza and B, Parainfluenza, Human metapneumovirus and Adenovirus. (pediatriceducation.org)
Parainfluenza tests diagnose four common viruses that cause respiratory illnesses, including croup and bronchitis. (phynetinc.com)

Fast Five Quiz: Pediatric Respiratory Syncytial Virus Management - Medscape - Mar 03, 2022. (medscape.com)
Feb. 28, 2022-Vanderbilt research on the impact of the antibiotic azithromycin during severe respiratory syncytial virus (RSV) bronchiolitis overwhelmingly support current national bronchiolitis guidelines, which recommend against antibiotics during acute bronchiolitis due to lack of effect on the acute illness. (vumc.org)
Fast Five Quiz: Respiratory Syncytial Virus (RSV) - Medscape - Nov 08, 2022. (medscape.com)

RSV is famously known as causing bronchiolitis , an asthma like condition in infants, but it can also cause a pneumonitis , a pneumonia , a bad cough, an upper respiratory illness. (mayoclinic.org)
In severe cases, however, RSV can spread to the lower respiratory tract, causing pneumonia or bronchiolitis (inflammation of the small airways in the lungs). (isglobal.org)
UNLABELLED: One of the major questions regarding long-term side effects of bronchiolitis by respiratory syncytial virus (RSV) is whether or not it induces asthma in later life. (rug.nl)
Moll, H A. / Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children : a quantitative review . (rug.nl)
In order to evaluate further the relationship between acute bronchiolitis in infancy and subsequent respiratory problems, children prospectively followed up from the time of their admission to hospital were reviewed along with a group of matched controls recruited at the previous five and a half year assessment. (bmj.com)
This study supports the claim that the excess respiratory symptoms after acute bronchiolitis are not due to familial or personal susceptibility to atopy. (bmj.com)
It is well documented that infants requiring admission to hospital with acute respiratory syncytial virus (RSV) bronchiolitis in the first year of life are more likely to have recurrent episodes of coughing and wheezing subsequently. (bmj.com)
The most common cause of bronchiolitis is a virus. (ahealthyme.com)
Bronchiolitis is most often caused by the respiratory syncytial virus. (ahealthyme.com)
001), while hospitalization rates for lower respiratory tract diseases excluding bronchiolitis did not vary significantly (P for trend = .20). (nih.gov)
During 1980-1996, rates of hospitalization of infants with bronchiolitis increased substantially, as did the proportion of total and lower respiratory tract hospitalizations associated with bronchiolitis. (nih.gov)
This winter we are expecting high levels of a childhood respiratory disease called Bronchiolitis, caused by the Respiratory syncytial Virus (RSV). (yaldingdoctors.nhs.uk)

SGS has a wealth of expertise in early phase clinical trials, first in human (FIH) studies, human challenge testing and complex PK/PD studies with a focus on infectious diseases, vaccines, and respiratory therapeutics. (manufacturingchemist.com)
Viral vector vaccines use a harmless, modified version of the virus to deliver instructions to the body's cells for how to recognize and fight the virus. (spokesman.com)
Therefore, combination vaccines against both viruses are very common and a variety of traditional live attenuated and inactivated BRSV and BPIV3 vaccines are commercially available. (ugent.be)
There currently are no approved vaccines for that virus. (theperfectenemy.com)

But we are seeing an unusual influx of RSV patients ages 2-4 year this year, likely because these toddlers and young children were not exposed to the virus as newborns when most people were wearing masks and when schools were closed, so many have not developed protective antibodies. (universityofcalifornia.edu)
Breastfeeding the kid is also an effective method to build resistance to the virus as breast milk contains antibodies and other immunity-boosting nutrients. (countyenews.com)
Maternal immunisation to boost respiratory syncytial virus (RSV) specific antibodies in pregnant women is a strategy to enhance infant protection. (biomedcentral.com)
Titers detect the presence of antibodies, which measure your body's ability to fight off certain pathogens -- most commonly viruses such as Measles, Mumps, and Rubella. (arcpointlabs.com)

Monitoring by the Centers for Disease Control and Prevention (CDC) and reports from U.S. hospitals are showing a spike in cases of respiratory syncytial virus (RSV) nationwide. (riversideonline.com)
Doctors and health systems throughout the country are seeing an uptick in cases of respiratory syncytial virus, or RSV, a viral respiratory illness that usually causes mild, cold-like symptoms. (berriencounty.org)
Many locations in the United States are experiencing a sharp rise in the number of cases of respiratory syncytial virus (RSV) as well as pediatric flu. (providence.org)

RSV is recognised as a significant cause of respiratory illness in all age groups. (manufacturingchemist.com)
For mild symptoms or to get tested for RSV or another respiratory illness, contact your primary care provider or nearest urgent care center. (berriencounty.org)
Dr. Jacobson says respiratory syncytial virus can start a cycle of illness within a family. (mayoclinic.org)
it is the leading cause of severe acute respiratory illness worldwide. (isglobal.org)
There are two different strains of virus- Type A and Type B that may lead to differences in severity of illness. (researchnester.com)
Because the health and safety of our patients, families, visitors and staff is of utmost importance to us and to prevent the spread of the virus causing COVID19 illness, new visitation restrictions are now in effect. (luriechildrens.org)
Human respiratory syncytial virus (RSV) is a common cause of respiratory illness in infants and children. (luriechildrens.org)
Background: Respiratory syncytial virus (RSV) is the most common cause of severe respiratory illness in infants. (ruc.dk)
If over the counter medication doesn't seem to help, it may be indicative of a more serious health issue, like respiratory illness. (activebeat.com)
If left untreated, RSV almost always progresses a serious lower respiratory tract illness-like bronchitis and eventually, pneumonia. (activebeat.com)
Corporate Authors(s) : for the South African Severe Acute Respiratory Illness (SARI) Surveillance Group Published Date : July 01 2017 Source : J Infect. (cdc.gov)
Due to this increased activity, CDC encourages broader testing for RSV among patients presenting with acute respiratory illness who test negative for SARS-CoV-2, the virus that causes COVID-19. (cdc.gov)
Clinicians should consider testing patients with a negative SARS-CoV-2 test and acute respiratory illness or the age-specific symptoms presented above for non-SARS-CoV-2 respiratory pathogens, such as RSV. (cdc.gov)
Clinicians should report laboratory-confirmed RSV cases and suspected clusters of severe respiratory illness to local and state health departments according to their routine reporting requirements. (cdc.gov)
So, in practice, what happened is, when we realized that we were in the middle of a deadly respiratory outbreak, we put out a high alert for people to watch out for chimpanzees who might have succumbed to the illness. (cdc.gov)
We are seeing more kids with worse respiratory illness than we've seen in the past, everything from babies a few months old to teenagers," Flores says. (nationalgeographic.com)
The season is ramping up even as the U.S. continues to combat the COVID-19 pandemic and a new surge of respiratory syncytial virus (RSV), a critical illness for youth that has put a strain on children's hospitals. (ksn.com)
Between October 2008 and September 2010, nose and throat swabs from adults and children (approximately 20 per week) presenting with an acute respiratory illness to the Ninh Hoa General Hospital were collected. (who.int)

This air-bourn virus can hit babies and young children extremely hard, graduating quickly from seemingly mild influenza symptoms to severe bronchitis and even pneumonia within four to six days following viral exposure. (activebeat.com)

In adults, RSV usually causes upper respiratory tract symptoms but can cause lower respiratory tract disease, especially in elderly and in immunocompromised persons (4-6). (cdc.gov)
Respiratory syncytial virus is a seasonal respiratory virus that usually causes mild, cold-like symptoms. (universityofcalifornia.edu)
However, some infants and people with weakened immune systems can continue to spread the virus for as long as four weeks, even after they stop showing symptoms. (universityofcalifornia.edu)
RSV symptoms can be very similar to other contagious respiratory viruses. (uchicagomedicine.org)
While this respiratory virus often causes mild, cold-like symptoms, RSV in children can be serious and may cause severe illnesses. (stmarysmc.com)
For instance, people with cold like symptoms should avoid kissing babies at risk for respiratory syncytial virus. (mayoclinic.org)
However, cyanosis, apnea and wheezing are all the severe symptoms of RSV developed in the later stage when the virus has already invaded the lower respiratory tract of an individual. (researchnester.com)
It's one of the many respiratory viruses that causes what we know as cold symptoms in adults and children. (providence.org)
RSV may also cause more significant respiratory symptoms, difficulty breathing and dehydration due to difficulty eating and/or drinking in younger children. (providence.org)
Infants and toddlers are more likely to have RSV symptoms affecting their lungs, such as wheezing, fast breathing, or respiratory distress. (providence.org)
It's not always possible to tell which virus is causing symptoms without a test, however most people with cold symptoms do not need to be tested for RSV. (providence.org)
Handwashing, mask wearing, staying home from work, school or day care when sick and avoiding anyone who has respiratory symptoms are vital in preventing the spread of RSV, influenza and COVID-19. (providence.org)
So the goal of treatment is to ease symptoms and wait for the body's immune system to fight off the virus. (ahealthyme.com)
So, they're a group of viruses that causes sniffles in children, maybe fevers, sore throats, cold-like symptoms, and usually don't cause that much harm in people, except under rare circumstances. (cdc.gov)
During outbreaks with the usual respiratory viruses, the signs and symptoms can suggest the correct diagnosis in most cases. (medscape.com)
The symptoms may worsen with time, and new respiratory symptoms, such as dyspnea and cyanosis, may appear. (medscape.com)
This study included more than 60,000 adults ages 60 or older in 22 countries, including the U.S. Moderna stated that mRNA-1345 achieved an efficacy of 83.7% in preventing RSV lower respiratory tract disease defined by two or more symptoms. (theperfectenemy.com)

In Berrien County, cases of RSV and other respiratory illnesses have been increasing over the last 10 weeks, with roughly 40 new RSV cases per week. (berriencounty.org)
Wait times may be elevated as respiratory illnesses reach seasonal peak levels. (berriencounty.org)
Consider having your children wear a mask in public places, including school, when you know local case rates of respiratory illnesses are high. (berriencounty.org)
We are also concerned about a large influx of patients with other respiratory illnesses, including COVID-19 and influenza. (providence.org)
It can cause illnesses that range from asymptomatic to severe respiratory distress and possibly death. (pediatriceducation.org)

It commonly appears during the coldest and wettest months of the year, similarly to the influenza virus. (efcni.org)

Hospital- of specimens containing influenza A/B virus and RSV by ized adults with RSV were more likely to be homeless, and using a rapid PCR assay (Focus Diagnostics, https://www. (cdc.gov)
Editorial Note: During the RSV season, health-care providers should consider RSV as a cause of acute respiratory disease in both children and adults. (cdc.gov)
While most people recover from RSV in a week or two, the virus can be serious, especially for infants, adults over the age of 50 and individuals with compromised immune systems. (berriencounty.org)

Abstract To study the role of interleukin-33 (IL-33) in acute exacerbation of allergic asthma induced by respiratory syncytial virus (RSV). (fudan.edu.cn)

The Centers for Disease Control and Prevention says kissing the face of a child with RSV also can cause the virus to jump from person to person. (mayoclinic.org)
The Centers for Disease Control and Prevention (CDC) is issuing this health advisory to notify clinicians and caregivers about increased interseasonal respiratory syncytial virus (RSV) activity across parts of the Southern United States. (cdc.gov)
As a result of the surge in these viruses , our emergency rooms, clinics and urgent care centers are seeing unprecedented patient volumes. (providence.org)
1 Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. (nih.gov)

Respiratory syncytial virus (RSV), a common cause of winter outbreaks of acute respiratory disease, results in an estimated 90,000 hospitalizations and 4500 deaths each year from lower respiratory tract disease among infants and young children in the United States (1). (cdc.gov)

RÉSUMÉ Bien que le virus respiratoire syncytial (VRS) soit l'une des principales causes de mortalité et de morbidité chez les jeunes nourrissons, les modes et les tendances de la circulation de ce virus au Maroc sont très peu connus. (who.int)

Human metapneumovirus (hMPV) is a single-stranded RNA virus in the Paramyxoviridae family that is closely related to avian metapneumovirus. (pediatriceducation.org)

About 58,000 children younger than 5 years old are hospitalized because of the respiratory syncytial virus (RSV) annually in the United States. (stmarysmc.com)
Respiratory syncytial virus (RSV) was associated with significant global morbidity and mortality in children and infants younger than 5 years, according to findings published in The Lancet . (infectiousdiseaseadvisor.com)
A recent study estimated that respiratory syncytial virus (RSV) causes 1 in 50 deaths among children younger than 5 years and 1 in 28 deaths in those younger than 6 months globally. (medscape.com)

It then spreads down into the windpipe (trachea) and lungs (lower respiratory tract). (ahealthyme.com)

We did this study, which was a study of rhinovirus C in chimpanzees, because we found ourselves in the middle of a severe outbreak of respiratory disease in a wild chimpanzee population in Uganda. (cdc.gov)

Early diagnosis and medical intervention prior to the progression from upper to lower respiratory tract viral involvement is essential to positively affect the clinical course. (nih.gov)
The greatest risk of disease progression from upper to lower respiratory tract disease is during the early posttransplant period for HSCT recipients, with lymphopenia being an important risk factor. (nih.gov)
In conclusion, these data support the continued effectiveness of palivizumab prophylaxis for severe RSV lower respiratory tract disease in a large cohort of high-risk infants from geographically diverse pediatric offices and clinics. (emmes.com)
Elderly persons may have a lower frequency of upper respiratory complaints. (medscape.com)

On the other hand, the host's immune response considerably contributes to the tissue damage in the upper respiratory tract. (ugent.be)

In order to prevent spread of the endemic pathogens bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) between herds, knowledge of indirect transmission by personnel and fomites is fundamental. (biomedcentral.com)
Bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) are contagious pathogens detrimentally affecting production and animal welfare in the cattle industry. (biomedcentral.com)

Changes in Influenza and Other Respiratory Virus Activity During the COVID-19 Pandemic - United States, 2020-2021. (medscape.com)

A 3-D rendering of a live-attenuated respiratory syncytial virus (RSV) particle, captured in a near-to-native state by cryo-electron tomography. (emoryhealthsciblog.com)

Mortality associated with influenza and respiratory syncytial virus in the United States. (medscape.com)
Resveratrol also significantly reduced the replication of monkeypox virus, a zoonotic virus that is endemic in Western and Central Africa and causes human mortality. (researchgate.net)

The viruses are part of the bovine respiratory disease complex and are endemic worldwide. (biomedcentral.com)

This year, emergency departments nationwide are seeing an unusually early surge in very young and elderly patients with respiratory distress, often caused by respiratory syncytial virus or RSV. (universityofcalifornia.edu)
He was not tachypneic and had no signs of respiratory distress. (pediatriceducation.org)

Respiratory syncytial virus (RSV) is a common virus that affects the human respiratory system. (riversideonline.com)
The lung is a critical prophylaxis target for numerous infectious agents, including human respiratory syncytial virus (RSV) and influenza. (bruker.com)
The U.S Department of Health and Human Services warns of the advent of the RSV virus every year during fall, winter, and spring. (countyenews.com)
Human respiratory syncytial virus (RSV), also known as Human orthopneumovirus, is a multinucleated, enveloped, single-stranded RNA virus, which can affect any part of the respiratory tract and lead to intense inflammation. (researchnester.com)
The global human respiratory syncytial virus treatment market is anticipated to project a CAGR of over 12%, during the forecast period (2019-2027). (researchnester.com)
The market is segmented by route of administration into oral and parenteral form, out of which, the parenteral form segment is anticipated to witness higher demand in the global human respiratory syncytial virus treatment market on account of its high therapeutic concentrations that are achieved reliably and readily. (researchnester.com)
Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. (microbiologyresearch.org)
The results indicate that human nasal mucosa can carry both BCoV and BRSV RNA after exposure to virus shedding calves, but the carriage seems short-lived and the transmission potential is likely limited. (biomedcentral.com)
However, as related viruses like human respiratory syncytial virus (HRSV) and human coronavirus 229E remain infective for several hours on contaminated surfaces like countertops and surgical gloves [ 10 , 11 ], there is a potential for indirect transmission. (biomedcentral.com)
Human nasal mucosa might also be a vector for inter-herd virus transmission, as traffic of personnel between herds is common. (biomedcentral.com)
It is intriguing to wonder where RSV, a virus whose only known reservoir is human, hides - a enigma that makes it even harder to understand and anticipate its seasonality. (vaccinestogether.org)
ENTERIC cytopathogenic human orphan (ECHO) viruses. (medscape.com)
And with those samples, we were able to use next- generation DNA sequencing methodologies to identify the virus, which, again, turned out to be this very common human virus that had never been seen in chimps before. (cdc.gov)
Laboratory capacity is needed in central Viet Nam to provide early warning to public health authorities of respiratory outbreaks of importance to human health, for example the outbreak of influenza A(H1N1) pandemic in 2009. (who.int)

Respiratory syncytial virus most often affects young children and older people, especially those with other health issues. (spokesman.com)
In the United States, 60% of infants are infected during their first RSV season, and nearly all children will have been infected with the virus by 2-3 years of age. (phys.org)
If you're a parent or guardian, here are some other things you need to know about RSV, including how to help protect your children against this virus. (stmarysmc.com)
It is so common that most children become infected with the virus by the time they reach two years of age . (isglobal.org)
Children who are infected with the virus can be contagious for up to 3 to 8 days and in certain cases with kids who have weak immunity, the virus can stay contagious for up to 4 weeks. (countyenews.com)
Researchers estimated the global disease burden of respiratory syncytial virus among children and infants. (infectiousdiseaseadvisor.com)
This flu season is coming on the heels of a nasty spike of RSV, or respiratory syncytial virus, cases in children and just as COVID-19 cases are climbing - again. (whnt.com)

WAFP President Mark Johnson, MD, and more than 35 other health officers and health care leaders released a joint statement Friday urging the public to wear masks indoors to mitigate the surge in respiratory viruses. (wafp.net)

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen. (bvsalud.org)

Chronic IL-33 expression predisposes to virus induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity[J].J Allergy Clin Immunol, 2018, 141:1607-1619. (fudan.edu.cn)

Palivizumab prophylaxis of respiratory syncytial virus disease in 2000-2001: results from The Palivizumab Outcomes Registry. (emmes.com)
The objective of the Registry was to characterize the population of infants receiving prophylaxis for respiratory syncytial virus (RSV) disease by describing the patterns and scope of usage of palivizumab in a cross section of US infants. (emmes.com)
As import of birds and products from several Asian countries into the European Union (EU) is forbidden (DG Sanco Decision 2004/122/EC), the birds were humanely sacrificed and immediately sent to the Veterinary and Agrochemical Research Centre for routine diagnosis to exclude influenza and Newcastle disease viruses. (cdc.gov)
We'll be talking about a deadly respiratory disease in wild chimpanzees. (cdc.gov)

A lab test of nasal fluid or another respiratory specimen to check for RSV. (medlineplus.gov)

The 2014-2015 National Impact of the 2014 American Academy of Pediatrics Guidance for Respiratory Syncytial Virus Immunoprophylaxis on Preterm Infants Born in the United States. (medscape.com)
WAFP, along the with the Washington State Medical Association and the Washington Chapter of the American Academy of Pediatrics, released a joint statement urging the public to take precautions as respiratory syncytial virus (RSV) spike throughout Washington. (wafp.net)

Since July 1992, a total of 100 clinical and public health laboratories in 47 states have participated in NREVSS and have reported weekly to CDC the number of specimens tested for RSV by the antigen-detection and virus-isolation methods and the number of positive results. (cdc.gov)
BACKGROUND : External quality assessments (EQAs) for the molecular detection of respiratory syncytial virus (RSV) are necessary to ensure the provision of reliable and accurate results. (up.ac.za)
34%[95%CI-42%to-25%],respectively).Respiratory effect, but they also are subject to biases, including secular syncytial virus (RSV) activity was associated with strong trends and changes in detection or reporting ( 8 , 9 ). (cdc.gov)
There can be difficulties in detecting respiratory viruses including not actually testing for a particular organism or differences in detection methods. (pediatriceducation.org)
The primary aim of this study was to assist the Virology Laboratory at the Nha Trang Pasteur Institute (NTPI) to develop laboratory preparedness for respiratory virus outbreaks, including the detection of common respiratory viruses and avian influenza viruses. (who.int)

Respiratory syncytial virus, or RSV, is a common respiratory virus. (medlineplus.gov)
As with the "common cold," influenza, and COVID-19, individuals with RSV should take measures to prevent spreading the virus. (riversideonline.com)
RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae , which includes common respiratory viruses such as those causing measles and mumps. (phys.org)

Seasonal fluctuations in virus activity, which could influence the variations,particularlyinRSVactivity,maskedtheimpact baseline and the post-PCV estimates of incidence ( 7 , 10 ). (cdc.gov)
Every year, respiratory syncytial virus (RSV) makes its expected and dreaded seasonal appearance at a more or less predictable time, depending on multiple factors that still remain unclear but depend basically on a combination of latitude, relative humidity, and temperature. (vaccinestogether.org)

Anatomy24

Organisms54

Diseases30

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes36

Disciplines and Occupations2

Information Science4

Named Groups3

Health Care10

Geographicals1

Detection of antibody to bovine syncytial virus and respiratory syncytial virus in bovine fetal serum. (1/1481)

Maternal immunization. (2/1481)

Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines. (3/1481)

Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. (4/1481)

Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. (5/1481)

A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgA. (6/1481)

Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. (7/1481)

Induction of CD95 (Fas) and apoptosis in respiratory epithelial cell cultures following respiratory syncytial virus infection. (8/1481)

Respiratory Syncytial Viruses

Respiratory Syncytial Virus Infections

Respiratory Syncytial Virus, Human

Respiratory Syncytial Virus, Bovine

Respiratory Syncytial Virus Vaccines

Respirovirus Infections

Bronchiolitis, Viral

HN Protein

Viral Fusion Proteins

Sigmodontinae

Bronchiolitis

Respiratory Tract Infections

Nasopharynx

Metapneumovirus

Viral Proteins

Paramyxoviridae Infections

Antibodies, Viral

Antigens, Viral

Virus Diseases

Virus Replication

Pneumonia, Viral

Viral Envelope Proteins

Parainfluenza Virus 3, Human

Virus Cultivation

Vaccinia virus

RNA Viruses

Lung

Neutralization Tests

RNA, Viral

Murine pneumonia virus

Nasal Lavage Fluid

Mice, Inbred BALB C

Cell Line

Antiviral Agents

Respirovirus

Vero Cells

Cattle Diseases

Infant, Newborn

Seasons

Viral Vaccines

Parainfluenza Virus 3, Bovine

Molecular Sequence Data

Virus Shedding

Pneumovirus Infections

Cercopithecus aethiops

Pneumovirus

Orthomyxoviridae

Virology

Vaccines, Attenuated

Antibodies, Monoclonal

Virus Assembly

Paramyxoviridae

Viruses

Genes, Viral

Cytopathogenic Effect, Viral

Fluorescent Antibody Technique, Direct

Pulmonary Eosinophilia

Fluorescent Antibody Technique

Enzyme-Linked Immunosorbent Assay

Parainfluenza Virus 1, Human

Cattle

Nasal Mucosa

Receptors, Virus

Influenza, Human

Vaccines, Inactivated

Amino Acid Sequence

Viral Plaque Assay

Measles virus

Respiratory System

Vaccines, Synthetic

Arvicolinae

Simian virus 40

Influenza A Virus, H1N1 Subtype

Parainfluenza Vaccines

Plant Viruses

DNA Viruses

Influenza A Virus, H3N2 Subtype

Reverse Transcriptase Polymerase Chain Reaction

Parainfluenza Virus 2, Human

Defective Viruses