Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Respiratory Mucosa: The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Adenoids: A collection of lymphoid nodules on the posterior wall and roof of the NASOPHARYNX.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Olfactory Mucosa: That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.Mucociliary Clearance: A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.Respiratory System: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Administration, Intranasal: Delivery of medications through the nasal mucosa.Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Organ Culture Techniques: A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1)Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Laryngeal Mucosa: The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Smog: A mixture of smoke and fog polluting the atmosphere. (Dorland, 27th ed)Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Cholestanones: CHOLESTANES substituted with any number of keto groups.Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).Secosteroids: Steroids in which fission of one or more ring structures and concomitant addition of a hydrogen atom at each terminal group has occurred.Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.Otitis Media, Suppurative: Inflammation of the middle ear with purulent discharge.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Otitis Media: Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.Vulvovaginitis: Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.Infectious Bovine Rhinotracheitis: A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.Herpesvirus 1, Bovine: A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.Balanitis: Inflammation of the head of the PENIS, glans penis.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Alphaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.Herpesvirus 5, Bovine: A species of VARICELLOVIRUS that causes a fatal MENINGOENCEPHALITIS in calves.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Respiratory Tract DiseasesAsthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Principal Component Analysis: Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Teratocarcinoma: A malignant neoplasm consisting of elements of teratoma with those of embryonal carcinoma or choriocarcinoma, or both. It occurs most often in the testis. (Dorland, 27th ed)Dry Powder Inhalers: A device that delivers medication to the lungs in the form of a dry powder.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma. (1/2809)BACKGROUND: Inhaled corticosteroids and beta agonists are the most commonly used treatments in asthma and are often used together. Recent evidence suggests that many of the anti-inflammatory actions of corticosteroids are mediated by cross-talk between the activated glucocorticoid receptor (GR) and other transcription factors such as the pro-inflammatory nuclear factor kappa B (NFkappaB). Beta agonists can activate the transcription factor cAMP response element binding protein (CREB). A mutual inhibition between GR and CREB occurs in vitro which raises the possibility of a negative interaction between corticosteroid and beta agonist drugs. A study was undertaken to determine whether these interactions occur during treatment with beta2 agonists and corticosteroids in asthma. METHODS: Seven subjects who were participating in a randomised, placebo controlled, crossover study of six weeks treatment with inhaled budesonide (400 microg twice daily), terbutaline (1 mg four times daily), and combined treatment were recruited. Biopsy samples of the bronchial mucosa were obtained after each treatment and analysed for the DNA binding activity of GR, CREB, and NFkappaB. RESULTS: Budesonide increased GR activity (p<0.05) and decreased NFkappaB activity (p<0.05). No treatment combination altered CREB activity and terbutaline had no significant effects on any transcription factor. CONCLUSIONS: Inhaled corticosteroids have significant effects on GR and NFkappaB activity in bronchial mucosa. A negative interaction between inhaled corticosteroids and beta agonists was not found. (+info)
Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus. (2/2809)Respiratory syncytial virus (RSV) is a mucosally restricted pathogen that can cause severe respiratory disease. Although parenteral administration of sufficient RSV-specific IgG can reduce severity of lower respiratory tract infection in high-risk infants, delivery of antibody by direct airway administration is an attractive alternative. Topical and parenteral administration of an IgA monoclonal antibody (MAb) specific for the RSV F glycoprotein was compared with an IgG MAb, specific for the same antigenic site, for ability to protect mice against RSV infection. Administration of RSV-specific IgG was more effective in reducing RSV titers in lung (4.6 log10 pfu/g) than IgA MAb (3.6 log10 pfu/g) when given intranasally immediately prior to infection (P=.005). RSV titers in the nose were reduced only by prophylactic administration of IgG parenterally. Therefore, topical administration of IgA is no more effective than topically administered IgG and is less effective than systemically administered IgG for protecting against RSV infection. (+info)
Differential sensitivity of normal and cystic fibrosis airway epithelial cells to epinephrine. (3/2809)1. Exposure to epinephrine has been shown to have a range of effects on cells and tissues. A recent study suggested that the proliferative ability of CF epithelial cells, exposed to high concentrations of epinephrine (200 - 300 microM), was reduced when compared to that of normal cells. This approach could potentially provide a means to effectively separate cells with functional cyclic AMP-dependent Cl-ion transport from those defective in this pathway. 2. The sensitivity to killing by epinephrine is reported here for four different CF cell lines, three normal cell lines, and two CF epithelial cell lines complemented with wild-type (wt) CF transmembrane conductance regulator (CFTR) cDNA. 3. While each cell line exhibited varying sensitivity to 200 microM epinephrine, no predictable pattern was observed between the expression of wt-CFTR and cell survival following epinephrine exposure. Overall, normal cell lines did exhibit a greater resistance to epinephrine-induced cell death although, the most resistant cell line was derived from CF tracheal epithelium (SigmaCFTE29o-). 4. The expression of exogenous wt-CFTR increased the survival of one cell line (CFDEo-) when compared to the parent line, but in another complemented line, survival was reduced. 5. These findings suggest that while epinephrine induces cell killing, it is not consistently effective for preferential selection of normal over CF cells. Although CFTR may play a role in the mechanism(s) of epinephrine killing, other factors such as cell density, proliferative ability, cell type origin and phenotype are involved. (+info)
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. (4/2809)T1/ST2 is an orphan receptor of unknown function that is expressed on the surface of murine T helper cell type 2 (Th2), but not Th1 effector cells. In vitro blockade of T1/ST2 signaling with an immunoglobulin (Ig) fusion protein suppresses both differentiation to and activation of Th2, but not Th1 effector populations. In a nascent Th2-dominated response, anti-T1/ST2 monoclonal antibody (mAb) inhibited eosinophil infiltration, interleukin 5 secretion, and IgE production. To determine if these effects were mediated by a direct effect on Th2 cells, we next used a murine adoptive transfer model of Th1- and Th2-mediated lung mucosal immune responses. Administration of either T1/ST2 mAb or T1/ST2-Ig abrogated Th2 cytokine production in vivo and the induction of an eosinophilic inflammatory response, but failed to modify Th1-mediated inflammation. Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses. (+info)
Epithelial P2X purinergic receptor channel expression and function. (5/2809)P2X purinergic receptor (P2XR) channels bind ATP and mediate Ca(2+) influx--2 signals that stimulate secretory Cl(-) transport across epithelia. We tested the hypotheses that P2XR channels are expressed by epithelia and that P2XRs transduce extracellular ATP signals into stimulation of Cl(-) transport across epithelia. Electrophysiological data and mRNA analysis of human and mouse pulmonary epithelia and other epithelial cells indicate that multiple P2XRs are broadly expressed in these tissues and that they are active on both apical and basolateral surfaces. Because P2X-selective agonists bind multiple P2XR subtypes, and because P2X agonists stimulate Cl(-) transport across nasal mucosa of cystic fibrosis (CF) patients as well as across non-CF nasal mucosa, P2XRs may provide novel targets for extracellular nucleotide therapy of CF. (+info)
Effect of fluticasone propionate and salmeterol on Pseudomonas aeruginosa infection of the respiratory mucosa in vitro. (6/2809)The purpose of this study was to investigate the effect of the corticosteroid, fluticasone propionate (FP), on Pseudomonas aeruginosa infection of the respiratory mucosa of an organ culture model in vitro. Organ cultures infected with P. aeruginosa had significantly (p< or =0.05) elevated levels of mucosal damage and significantly (p< or =0.05) less ciliated cells compared to controls. Preincubation of tissue with FP (10(-6) or 10(-5) but not 10(-7) M) prior to P. aeruginosa infection significantly (p< or =0.05) reduced the bacterially induced mucosal damage in a concentration-dependent manner. FP (10(-5) M) also significantly (p< or =0.05) prevented loss of ciliated cells. FP did not alter the density of bacteria adherent to the different mucosal features of the organ cultures, but did reduce total bacterial numbers due to the reduced amount of damaged tissue, which is a preferred site of P. aeruginosa adherence. It has previously been shown that the long-acting beta2-agonist salmeterol (4 x 10(-7)M) also reduces the mucosal damage caused by P. aeruginosa infection, probably via elevation of intracellular cyclic adenosine monophosphate concentrations. Preincubation of tissue with both 10(-7)M FP and 10(-7)M salmeterol, concentrations at which they did not by themselves influence the effect of P. aeruginosa infection, significantly (p< or =0.05) reduced P. aeruginosa-induced loss of cilia. However, there was no additional benefit from adding 4 x 10(-7)M salmeterol to 10(-6)M FP. In conclusion fluticasone propionate reduced mucosal damage caused by P. aeruginosa infection in vitro and preserved ciliated cells. There was a synergistic action with salmeterol in the preservation of ciliated cells. (+info)
M1/MUC5AC mucin released by human airways in vitro. (7/2809)A series of monoclonal antibodies which bind to a mucin known as M1 (anti-M1 MAbs) have also been shown to detect the product of the human gene MUC5AC. The aim of this investigation was to determine the concentration of the M1 mucin in the surface epithelium of human bronchial preparations by means of immunohistochemistry and in the bronchial fluid derived from human airways by means of an immunoradiometric assay. Human bronchial ring preparations from the resection material of 20 patients were challenged with methacholine, leukotriene D4, or anti-immunoglobulin E. Experiments were performed in preparations with an intact epithelium as well as in tissues in which the epithelium had been mechanically removed. The anti-M1 MAbs stained the goblet cells in the epithelium intensely and there was also light and less uniform staining in the submucosa. The M1/MUC5AC mucin in the fluids secreted by the bronchial preparations was not modified during either the experimental protocol or stimulation with the different secretagogues. However, in preparations in which the epithelium had been removed, there was a significant reduction in the amount of M1/MUC5AC mucin detected. These data suggest that the M1/MUC5AC mucin detected in the biological fluids produced by human airways in vitro may be released constantly, and principally from the goblet cells in the epithelial layer. (+info)
Arsenite exposure of cultured airway epithelial cells activates kappaB-dependent interleukin-8 gene expression in the absence of nuclear factor-kappaB nuclear translocation. (8/2809)Airway epithelial cells respond to certain environmental stresses by mounting a proinflammatory response, which is characterized by enhanced synthesis and release of the neutrophil chemotactic and activating factor interleukin-8 (IL-8). IL-8 expression is regulated at the transcriptional level in part by the transcription factor nuclear factor (NF)-kappaB. We compared intracellular signaling mediating IL-8 gene expression in bronchial epithelial cells cultured in vitro and exposed to two inducers of cellular stress, sodium arsenite (As(III)), and vanadyl sulfate (V(IV)). Unstimulated bronchial epithelial cells expressed IL-8, and exposure to both metal compounds significantly enhanced IL-8 expression. Overexpression of a dominant negative inhibitor of NF-kappaB depressed both basal and metal-induced IL-8 expression. Low levels of nuclear NF-kappaB were constitutively present in unstimulated cultures. These levels were augmented by exposure to V(IV), but not As(III). Accordingly, V(IV) induced IkappaBalpha breakdown and NF-kappaB nuclear translocation, whereas As(III) did not. However, both As(III) and V(IV) enhanced kappaB-dependent transcription. In addition, As(III) activation of an IL-8 promoter-reporter construct was partially kappaB-dependent. These data suggested that As(III) enhanced IL-8 gene transcription independently of IkappaB breakdown and nuclear translocation of NF-kappaB in part by enhancing transcription mediated by low levels of constitutive nuclear NF-kappaB. (+info)
CIL:49801, Primary human small airway epithelial cells immortalized with telomerase. CIL. Dataset
Nitric oxide gas phase release in human small airway epithelial cells | Respiratory Research | Full Text
Small airway (airway diameter , 1-2 mm) inflammation is thought to play a critical role in the pathogenesis of asthma including airways hyper-responsiveness, spontaneous exacerbations of symptoms, and tissue remodeling . Non-invasive markers of inflammation, such as NO gas in the exhaled breath, could assist in the management of airway inflammation, but the anatomical source remains unclear. Our study demonstrates that small airway epithelial cells can be differentiated at an air-liquid interface to express markers such as mucin and cilia. The differentiated epithelium produces a very small, but detectable, amount of NO gas at baseline. However, the production is significantly increased, due to the upregulation of iNOS, following exposure to soluble inflammatory mediators, most notably a combination of IL-1β, TNF-α and IFN-γ. As such, iNOS in the small airway epithelium is a probable source of NO in the exhaled breath of asthma.. Bronchioles are generally , 1 mm in diameter, are devoid of ...
Applications of Mouse Airway Epithelial Cell Culture for Asthma Research | Society for Mucosal Immunology
15-deoxy-Δ-Prostaglandin J <sub>2</sub> induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H <sub...
TY - JOUR. T1 - 15-deoxy-Δ-Prostaglandin J 2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H 292). AU - Chiba, Takahito. AU - Ueki, Shigeharu. AU - Ito, Wataru. AU - Kato, Hikari. AU - Takeda, Masahide. AU - Kayaba, Hiroyuki. AU - Furue, Masutaka. AU - Chihara, Junichi. PY - 2009/6/1. Y1 - 2009/6/1. N2 - Background: 15-Deoxy-Δ 12,14-prostaglandin J 2 (15d-PGJ 2), a major prostanoid metabolized from prostaglandin D 2 (PGD 2), plays an important role in various biological processes including inflammatory responses. 15d-PGJ 2 exerts its effects through two major receptors, chemoattractant receptor- homologous molecule expressed on Th2 cells (CRTH2) and peroxisome proliferator-activated receptor-γ (PPARγ). The 15d-PGJ 2/PPARγ system, in particular, regulates numerous biological processes including adipogenesis, apoptosis, and inflammation. Although our studies have shown that PGD 2 (metabolic precursor of 15d-PGJ 2) induces IL-8 and GM-CSF production, the role of 15d-PGJ 2 ...
Modification of gene expression of the small airway epithelium in response to cigarette smoking<...
TY - JOUR. T1 - Modification of gene expression of the small airway epithelium in response to cigarette smoking. AU - Harvey, Ben Gary. AU - Heguy, Adriana. AU - Leopold, Philip L.. AU - Carolan, Brendan J.. AU - Ferris, Barbara. AU - Crystal, Ronald. PY - 2007/1/1. Y1 - 2007/1/1. N2 - The earliest morphologic evidence of changes in the airways associated with chronic cigarette smoking is in the small airways. To help understand how smoking modifies small airway structure and function, we developed a strategy using fiberoptic bronchoscopy and brushing to sample the human small airway (10th-12th order) bronchial epithelium to assess gene expression (Affymetrix HG-U133A and HG-133 Plus 2.0 array) in phenotypically normal smokers (n = 16, 25 ± 7 pack-years) compared to matched nonsmokers (n = 17). Compared to samples from large (second to third order) bronchi, the small airway samples had a higher proportion of ciliated cells, but less basal, undifferentiated, and secretory cells, and contained ...
Culturing of respiratory viruses in well-differentiated pseudostratified human airway epithelium as a tool to detect unknown...
The Pulmonary Epithelium in Health and Disease, 1st Edition
Richard C. Boucher, MD | Marsico Lung Institute
Specialty Areas: Normal Physiology of Airway Surface Liquids (ASL); ASL System Failure in CF and COPD. Research Focus:. Dr. Bouchers lab has focused on the normal physiology of airway surface liquids (ASL) and how this system fails in airways diseases, e.g., cystic fibrosis and COPD. The lab pursues a variety of investigations into the functions of airway epithelia in health and disease. In general terms, the lab focuses on five interrelated areas of research:. ...
Screening Device for Differentiated Primary Cell Models of Airway Epithelia - Robert Lowery
Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7...
"One-step immortalization of primary human airway epithelial cells capa" by Jordan L. Smith, Liam C. Lee et al.
BACKGROUND: The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the mechanisms of oncogenesis. Easy establishment of immortalized but non-transformed human cells from various tissues would facilitate these genetic analyses. RESULTS: We report here a simple, one-step immortalization method that involves retroviral vector mediated co-expression of the human telomerase protein and a shRNA targeting the CDKN2A gene locus. We demonstrate that this method could successfully immortalize human small airway epithelial cells while maintaining their chromosomal stability. We further showed that these cells retain p53 activity and can be transformed by the KRAS oncogene. CONCLUSIONS: Our method simplifies the immortalization process and is broadly applicable for establishing immortalized epithelial cell lines from primary human tissues for cancer research.
Oxidative stress in Nipah virus-infected human small airway epithelial cells | Microbiology Society
Nipah virus (NiV) is a zoonotic emerging pathogen that can cause severe and often fatal respiratory disease in humans. The pathogenesis of NiV infection of the human respiratory tract remains unknown. Reactive oxygen species (ROS) produced by airway epithelial cells in response to viral infections contribute to lung injury by inducing inflammation and oxidative stress; however, the role of ROS in NiV-induced respiratory disease is unknown. To investigate whether NiV induces oxidative stress in human respiratory epithelial cells, we used oxidative stress markers and monitored antioxidant gene expression. We also used ROS scavengers to assess their role in immune response modulation. Oxidative stress was confirmed in infected cells and correlated with the reduction in antioxidant enzyme gene expression. Infected cells treated by ROS scavengers resulted in a significant decrease of the (F2)-8-isoprostane marker, inflammatory responses and virus replication. In conclusion, ROS are induced during NiV
Primary Small Airway Epithelial Cells; Normal, Human (HSAEC) ATCC ®
ATCC ® Normal Human Primary Small Airway Epithelial Cells, when grown in Airway Epithelial Cell Basal Media supplemented with Bronchial Epithelial Cell Growth Kit (ATCC PCS-300-040) components, provide an ideal cell system to propagate small airway epithelial cells in serum-free conditions. The cells are cryopreserved at the first passage to ensure the highest viability and plating efficiency. ATCC ® Primary Cell Solutions™ cells, media, supplements and reagents are quality tested together to guarantee optimum performance and reliability.
Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression...
Cigarettes vary in tobacco blend, filter ventilation, additives, and other physical and chemical properties, but little is known regarding potential differences in toxicity to a smokers airway epithelia. We compared changes in gene expression and cytokine production in primary normal human bronchia …
RvD3 and AT-RvD3 impact on airway epithelial cells and the resolution of inflammatory responses after acute lung injury in mice
Regulation of IL-1beta-mediated MUC2 gene in NCI-H292 human airway epithelial cells
This study demonstrates for the first time the effects of IL-1beta on the regulation of protein production as well as MUC2 gene transcription in cultured human airway epithelial cells. The effect of IL-1beta on the regulation of MUC2 protein was determined by flow cytometric analysis. The expression …
SUV39H1 reduction is implicated in abnormal inflammation in COPD<...
TY - JOUR. T1 - SUV39H1 reduction is implicated in abnormal inflammation in COPD. AU - Chen, Tzu Tao. AU - Wu, Sheng Ming. AU - Ho, Shu Chuan. AU - Chuang, Hsiao Chi. AU - Liu, Chien Ying. AU - Chan, Yao Fei. AU - Kuo, Lu Wei. AU - Feng, Po Hao. AU - Liu, Wen Te. AU - Chen, Kuan Yuan. AU - Hsiao, Ta Chih. AU - Juang, Jer Nan. AU - Lee, Kang Yun. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Chronic obstructive pulmonary disease (COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is causatively implicated in the abnormal inflammation observed in COPD. The SUV39H1 and H3K9me3 levels were reduced in peripheral blood mononuclear cells (PBMCs), primary human small airway epithelial cells (HSAEpCs) and lung tissues from COPD patients, which were correlated with poor lung function and the serum IL-8 and IL-6 levels. A specific SUV39H1 inhibitor, chaetocin, induced a distinct COPD panel of ...
JCI - IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
Increased mucus production is a common cause of morbidity and mortality in inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the precise molecular mechanisms for pathogenic mucus production are largely undetermined. Accordingly, there are no specific and effective anti-mucus therapeutics. Here, we define a signaling pathway from chloride channel calcium-activated 1 (CLCA1) to MAPK13 that is responsible for IL-13-driven mucus production in human airway epithelial cells. The same pathway was also highly activated in the lungs of humans with excess mucus production due to COPD. We further validated the pathway by using structure-based drug design to develop a series of novel MAPK13 inhibitors with nanomolar potency that effectively reduced mucus production in human airway epithelial cells. These results uncover and validate a new pathway for regulating mucus production as well as a corresponding therapeutic approach to mucus ...
Research Publications- Respiratory System | Respiratory Mucosa
Activation of transcription factor IL-6 (NF-IL-6) and nuclear factor-kappaB (NF-kappaB) by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells. Ozone (O(3)) is a major component of smog and an inhaled toxicant to the lung. O(3) rapidly reacts with the airway epithelial cell membrane phospholipids to... ...
Researchers explore SARS-CoV-2 at single cell resolution in human airway epithelial cells
Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic...
PACCM CF and Host Defense | Department of Medicine
The long-term and central goal of the Cystic Fibrosis Research Center at the University of Pittsburgh is to provide improved treatments, and ultimately a cure, for cystic fibrosis (CF). A collaborative effort by investigators in the Departments of Cell Biology and Physiology, Medicine, and Pediatrics, our strategy is to implement this goal using our strengths in the basic science of CFTR and epithelial ion transport and to translate our increasingly applied basic science knowledge to clinical investigations.. In order to achieve these goals we have established centers of excellence in three broad categories: Cell and Molecular Biology of CF, Infection and Inflammation in CF, and Clinical Studies in CF. These centers are summarized below:. Cell and Molecular Biology: The bulk of our research is conducted using primary human airway cell cultures established from CF and non-CF tissues that are made available by the more than 100 lung transplants that are performed annually at the University of ...
TRPV4-Mediated calcium-influx into human bronchial epithelia upon exposure to diesel exhaust particles | RTI
Effect of cytokines on ICAM-1 and ZO-1 expression on human airway epithelial cells<...
TY - JOUR. T1 - Effect of cytokines on ICAM-1 and ZO-1 expression on human airway epithelial cells. AU - Shahana, Shahida. PY - 2005/9. Y1 - 2005/9. N2 - The presence of adhesion molecules on airway epithelial cells may be important in recruiting leukocytes to the epithelium. The study aimed at investigating the effects of interleukin (IL)-4, IL-8, IL-13 and interferon-gamma (IFN-gamma) on cell viability and intracellular adhesion molecule (ICAM)-1 and zonula occludens protein (ZO)-1 expression on cultured human basal and columnar airway epithelial cells. Cycloheximide (CHX) induced cell death in both cell lines. The cytokines IL-4, IL-8, IL-13 and IFN-gamma had only minor effects on cell proliferation in the columnar 16HBE14o-cells, and inhibited the effects of CHX on cell death. IFN-gamma increased ICAM-1 expression in both cell lines. Western blot analysis showed that CHX inhibited both ICAM-1 and ZO-1 expression in the basal cell line. A combination of IL-4 and IFN-gamma appeared to break ...
Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers. (Research). - Free Online...
Normal Human Bronchial Epithelial Cells<...
In Vitro Assessment of Nano-Cerium Oxide (nCeO2) and Nano-Ferric Oxide (nFe2O3) on Fibrogenic and Carcinogenic Potential
Goal of the present study is to investigate the specific cellular responses to nCeO2 and nFe2O3 in various lung cell types and develop an in vitro chronic exposure model to predict the potential fibrogenic and carcinogenic effects. Primary human lung fibroblasts were treated with nCeO2 (size dXRD = 17 nm, SSA = 61 m2/g) and direct stimulation of collagen production (a hallmark of fibrosis) was evaluated. In separate experiments, primary human small airway epithelial cells were exposed to a sub-lethal concentration (0.625 µg/cm2) of nCeO2 and nFe2O3 (size dXRD = 20 nm, SSA = 50 m2/g) for 6 weeks and their effects on cell transformation and invasion were evaluated. Our results showed new data that nCeO2 can induce a dose-dependent increase in collagen production by lung fibroblasts; nCeO2 can induce proliferation of lung epithelial cells as compared to vehicle-treated control and nFe2O3 induced neoplastic transformation of epithelial cells as determined by soft-agar colony formation assay and transwell
Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport...
Lin, H., Li, H., Cho, H.-J., Bian, S., Roh, H.-J., Lee, M.-K., Kim, J. S., Chung, S.-J., Shim, C.-K. and Kim, D.-D. (2007), Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies. J. Pharm. Sci., 96: 341-350. doi: 10.1002/jps.20803 ...
JCI - Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling
Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of asthma is indirect airway hyperresponsiveness (AHR), and a prominent molecular endotype is the presence of type 2 inflammation. The underlying basis for type 2 inflammation and its relationship to AHR are incompletely understood. We assessed the expression of type 2 cytokines in the airways of subjects with and without asthma who were extensively characterized for AHR. Using quantitative morphometry of the airway wall, we identified a shift in mast cells from the submucosa to the airway epithelium specifically associated with both type 2 inflammation and indirect AHR. Using ex vivo modeling of primary airway epithelial cells in organotypic coculture with mast cells, we show that epithelial-derived IL-33 uniquely induced type 2 cytokines in mast cells, which regulated the expression of epithelial IL33 in a feed-forward loop. This ...
3896 Purpose: To evaluate the oncogenic impact of p53 knockdown, mutant K-RASV12, mutant EGFR alone and their combination on tumorigenicity of a newly developed immortalized human bronchial epithelial cell line. Background: Molecular analysis of lung cancer has revealed several genetic and epigenetic alterations in the multistep pathogenesis of lung cancer. However, little is known about the relative importance of each individual alteration on the tumorigenic process. One approach is to use a model system in which the contribution of each genetic alteration to lung tumorigenesis can be assessed individually and combinatorially. We have developed an in vitro model system using normal human bronchial epithelial cells that overexpress Cyclin-dependent kinase 4 and human telomerase. Ectopic expression of these two genes enables the cells to bypass the growth inhibitory signals of the p16/Rb pathway and also replicative senescence induced by shortened telomeres. We manipulated this cell line (HBEC3), ...
Global gene expression analysis of Act1's effects in airway epithelial cells (161.17) | The Journal of Immunology
Act1/CIKS is an intracellular protein that has been shown to play an important role in mediating IL-17A and IL-25 signaling effects. Recently, defects in Act1 function and/or expression has been implicated in inflammatory disease, such as psoriatic arthritis and atopic dermatitis. We have found that the modulation of Act1 expression levels in human airway epithelial cells changes the expression levels of some genes, in the absence of cytokine stimulation. RNAseq is a powerful new technique to quantitatively measure changes at the transcriptome level. Here we describe the use of RNAseq to globally analyze the effects of modulating Act1 expression in human airway epithelial cells. ...
Positive Inotropic Effects by Uridine Triphosphate (UTP) and Uridine Diphosphate (UDP) via P2Y2 and P2Y6 Receptors on...
In our study we demonstrate that the plasma levels of UTP are significantly elevated in patients with acute myocardial infarction. A combination of pharmacology and mRNA quantification indicates that UTP is probably acting via P2Y2 receptors in man, and via both P2Y2 and P2Y4 receptors on cardiomyocytes from mice. Our results indicate that UDP is a novel inotropic factor acting via P2Y6 receptors.. The first demonstration of UTP release used [3H]uridine-labeled endothelial cells. In the study, [3H]UTP release occurred in response to increased flow.27 Since the development of the first sensitive quantitative assay for UTP, its release has been measured from a variety of cells including platelets, leukocytes, primary airway epithelial cells, rat astrocytes, and several other cell lines.24 To our knowledge, we are now the first to quantify UTP levels in human plasma. UTP levels correlated significantly with ATP, indicating corelease of the nucleotides. The UTP levels were ≈1:10 of the ATP levels, ...
Airway Epithelial Cell Core | Research | Washington University in St. Louis
The airway epithelial cell core provides investigators with primary culture preparations of human and mouse airway epithelial cells. We routinely procure human tissues from lung transplantation donors and explanted lungs and surgical tissues, including those with lung disease. The core can also culture airway cells obtained by lung and nasal brushing or scraping. In collaboration with core users, Brody Lab members will establish cultures from mice or materials provided by the core users. Core users can be instructed on all methods for culture, manipulation and evaluation of preparations. Lead time of one month should be provided to allow for scheduling and the necessary period for cell growth. IRB permission may be required for some tissues and studies.. ...
Effect of active smoking on the human bronchial epithelium transcriptome | BMC Genomics | Full Text
Lung cancer is the most common cause of cancer-related deaths. Tobacco smoke exposure is the strongest aetiological factor associated with lung cancer. In this study, using serial analysis of gene expression (SAGE), we comprehensively examined the effect of active smoking by comparing the transcriptomes of clinical specimens obtained from current, former and never smokers, and identified genes showing both reversible and irreversible expression changes upon smoking cessation. Twenty-four SAGE profiles of the bronchial epithelium of eight current, twelve former and four never smokers were generated and analyzed. In total, 3,111,471 SAGE tags representing over 110 thousand potentially unique transcripts were generated, comprising the largest human SAGE study to date. We identified 1,733 constitutively expressed genes in current, former and never smoker transcriptomes. We have also identified both reversible and irreversible gene expression changes upon cessation of smoking; reversible changes were
The Anti-inflammatory Effect of Alpha-1 Antitrypsin in Rhinovirus-infected Human Airway Epithelial Cells | Abstract
NL20 ATCC ® CRL-2503™ Homo sapiens lung/bronchus Accident v
NL20-TA [NL20T-A] ATCC ® CRL-2504™ Homo sapiens Accident vic
NL20 (ATCC CRL-2503) is an immortalized, nontumorigenic human bronchial epithelial cell line derived from normal bronchus taken from an accident victim at autopsy. The cell line was established by transfection with the origin of replication-defective SV40 large T plasmid, p129. NL20 cells at passage 183 were inoculated into nude mice and a small slowly growing subcutaneous tumor developed from a minor clone in this otherwise stable cell line.
Role of H2O2 in the oxidative effects of zinc exposure in human airway epithelial cells. | Sigma-Aldrich
Bronchial epithelium, SEM - Stock Image C022/6437 - Science Photo Library
Bronchial epithelium. Coloured scanning electron micrograph (SEM) of a cultured bronchial epithelial cell. The respiratory epithelium is composed of a mixed population of ciliated, nonciliated, and mucous-secreting cells from proximal to distal airways. In vitro models ( cell culture) using primary cells and cell lines are essential for understanding the function and pathophysiology of these cells in diseases such as asthma. Magnification: x 2000 when printed 10 centimetres wide. - Stock Image C022/6437
As part of a robust innate immune system, the cells of the airway epithelium secrete fluid and proteins to create the highly proteinaceous periciliary liquid (PCL). Many proteins present in the PCL have proposed antimicrobial functions, including two of the most abundant proteins, BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1). The function of these two proteins in host defence is unresolved and we hypothesize that they interact with the respiratory pathogen, S. aureus, to limit infection.. Air-liquid interface (ALI) cultures of primary bronchial epithelial cells secrete many proteins present in the PCL, including BPIFA1 and BPIFB1. Pull down assays interacting cell secretions with S. aureus were used to visualise protein-bacterial interactions. Both BPIFA1 and BPIFB1 were shown interact strongly with S. aureus. Recombinant proteins generated in CHO cells exhibited similar binding to the endogenous proteins. Deglycosylation using PNGase F treatment prior to pull down assays highlighted that these ...
My research interests are to elucidate the cellular and molecular mechanisms by which environmental carcinogens cause lung cancer and to identify markers for the diagnosis, prognosis and treatment of this disease. We investigate genetic and epigenetic changes in oncogenes and tumor suppressor genes in specimens obtained from lung cancer patients and individuals at high risk for developing lung cancer. In addition, we apply new mouse models to investigate pathways of tobacco smoke carcinogen-mediated lung tumorigenesis. We would like to understand how airway epithelial cells are involved in the initiation and progression of lung tumors, and how they are influenced by environmental factors that increase lung cancer risk and how they respond to therapies. ...
Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7 |...
In this study, we examined the expression of the antimicrobial RNase 7 in cultured airway epithelial cells. We demonstrated that undifferentiated S-PBEC, primarily consisting of BCs, but not mucociliary-differentiated ALI-PBEC, expressed RNase 7 upon stimulation with the respiratory pathogen NTHi. This was in marked contrast to other examined innate immune mediators that were induced by NTHi in both S-PBEC and ALI-PBEC. Furthermore, differentiated ALI-PBEC displayed a decreased baseline RNase 7 expression compared with S-PBEC after 2 wk of culturing in air-exposed conditions. Cigarette smoke exposure, which caused transient disruption of the epithelial barrier function, reinitiated RNase 7 expression in the remaining undifferentiated BCs in ALI-PBEC, which was demonstrated using confocal microscopy and isolation of luminal and basal cell fractions. Moreover, we showed that this induction required activation of EGFR and the downstream ERK1/2 signaling pathway and furthermore demonstrated that ...
ALI Archives | BioLife Solutions
Bluhmki, T., Bitzer, S., Gindele, J. A., Schruf, E., Kiechle, T., Webster, M., Schymeinsky, J., Ries, R., Gantner, F., Bischoff, D., Garnett, J. and Heilker, R. Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model. Scientific Reports. 2020; 10(1). doi: 10.1038/s41598-020-69948-2. Read More ...
Pages that link to "Template:Respiratory Epithelium EM01" - Embryology
Rule of 6ix: March 2013
1) The main issue with this paper is this: these cell lines, although originally human, are all immortalized cancer cell lines characterised by markedly different biological properties when compared to normal human cells of the same tissue/cell type. They cant be readily used a surrogates for normal human tissue/cell types. None were primary cells nor were any even from recently acquired tissue samples from biopsies etc. People have infected primary human airway epithelial cultures with hCoV-EMC - so this can be done successfully - , although it would be more difficult for other tissue types as these cultures havent been developed. Some of these cell lines used may by chance lack key viral repressors of infection present in normal primary cells, which could skew results from cell culture infection experiments. Plus, a human tissue is not just a single cell type - they are composed of diverse kinds of cells that could together behave much, much differently than cell lines in culture ...
AsthmaAsthma is a condition characterized by paroxysmal narrowing of the bronchial airways due to inflammation of the bronchi...
Incidence of acute asthma, defined as the number of persons who develop asthma within a specific time period, is approximately % annually. Childhood asthma persists into adulthood in approximately 50% of cases. Those with symptoms persisting into the second decade of life usually have asthma throughout adulthood. Asthma prevalence is 6-10% (ie, million persons); one half of these cases are children (ie, 8-20% of all children). Overall, acute asthma represents about 2% of all ED visits Childhood asthma
Hackett, T.L., Shaheen, F., Johnson, A., Wadsworth, S., Pechkovsky, D.V., Jacoby, D.B., et al. (2008) Characterization of side...
Bronchial Epithelial Cell Medium-basal-phenol red free - Science PRO
Bronchial Epithelial Cell Medium-basal - Science PRO
Alveolar Epithelium - Explore the Science & Experts | ideXlab
Bronchial Cells Play a Key Role in Immune Response - Healthcanal.com : Healthcanal.com
Limber Lungs: One Type of Airway Cell Can Regene | Genetics And Genomics
RT-PCR for IL-8 (A), IL-6 (B), HOX1 (C), and COX2 (D) r | Open-i
Search Articles | University of Toronto Libraries
Edema of the gastrointestinal mucosa typically leads to severe abdominal pain; in the upper respiratory tract, it can be life- ... The skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue, swell over ... Tracheal intubation is required in these situations to prevent respiratory arrest and risk of death. Sometimes, the cause is ...
Bovine herpesvirus 5
Sites of latency include the CNS and mucosae of the nose and trachea. The disease has been documented in South America, the ... Signs of respiratory disease include tachycardia and tachypnea with pyrexia, dyspnea, mucoid nasal discharge, hypersalivation ... It causes meningoencephalitis and respiratory disease in cattle and sheep. As with all herpes viruses latent infection can ...
Patulous Eustachian tube
Chronic upper respiratory inflammatory diseases are almost always associated with PET; half of these patients report previous ... Lying head down may help since it increases venous blood pressure and congestion of the mucosa. With time patients may develop ... respiratory autophonia. At this stage, they hear "from inside".[this quote needs a citation] They describe hearing their own ... be a cause of patulous Eustachian tube due to the effects of pregnancy hormones on surface tension and mucus in the respiratory ...
Influenza A virus subtype H3N8
Aerosolized influenza virus is inhaled and embeds in the respiratory mucosa, of the upper and lower respiratory tract. The ... The ultimate source of the virus is respiratory tract secretions. Coughing horses can release the virus into the air, where it ... virus is attracted to the glycoproteins and mucopolysaccharides of the mucus coating the respiratory mucosa. If the infecting ... Equine influenza (EI) is a highly contagious respiratory disease of horses and related animals such as donkeys, mules and ...
The life expectancy of these patients is normal as long as the potential side effects of thickening mucosa, such as respiratory ... Its original name of 'lipoidosis cutis et mucosae' was changed to 'lipoid proteinosis cutis et mucosae' due to Urbach's belief ... Lipoidosis cutis et mucosae. Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin 273: 285-319 ... White or yellow infiltrates form on the lips, buccal mucosa, tonsils, uvula, epiglottis and frenulum of the tongue. This can ...
The respiratory epithelium that covers the erectile tissue (or lamina propria) of the turbinates plays a major role in the ... The flow of blood to the nasal mucosa, in particular the venous plexus of the conchae is regulated by the pterygopalatine ... The respiratory epithelium also serves as a means of access for the lymphatic system, which protects the body from being ... Animals with respiratory turbinates can breathe faster without drying out their lungs, and consequently can have a faster ...
Involvement of the skin or mucosa b. Respiratory difficulties c. Low blood pressure d. Gastrointestinal symptoms Low blood ... Respiratory symptoms and signs that may be present include shortness of breath, wheezes, or stridor. The wheezing is typically ... Respiratory difficulties may include: shortness of breath, stridor, or low oxygen levels among others. Low blood pressure is ... If death occurs, it is usually due to either respiratory (typically asphyxia) or cardiovascular causes (shock), with 0.7-20% of ...
Bovine herpesvirus 1
Shedding begins from the nasal mucosa as soon as infection occurs, and the virus has replicated in the upper respiratory tract ... The respiratory disease caused by BoHV-1 is commonly known as infectious bovine rhinotracheitis. This disease affects the upper ... BoHV-1 enters the animal through the mucous membrane in the respiratory tract or genital tracts. The main mode of disease ... BoHV-1 is also a contributing factor in shipping fever, also known as bovine respiratory disease (BRD). It is spread ...
Careful attention to respiratory status, acid-base balance, and treatment of other illnesses helps prevent the conditions under ... It is believed that shunting of blood away from the mucosa makes the mucous membrane ischaemic and more susceptible to injury. ... The ulcerations may be superficial and confined to the mucosa, in which case they are more appropriately called erosions, or ... and respiratory failure to the mortality independently of the stress ulceration cannot be ignored. Risk factors for stress ...
Nitrogen dioxide poisoning
Its poor solubility in water enhances its passage and its ability to pass through the moist oral mucosa of the respiratory ... effects of pollutant exposure on acute respiratory symptoms and respiratory function in adults". Arch Environ Health. 57 (2): ... Exposure to high level of nitrogen dioxide may lead to inflammation of the mucous membrane and the lower and upper respiratory ... 1997). "Respiratory effects associated with indoor nitrogen dioxide exposure in children". Int J Epidemiol. 26 (4): 788-96. doi ...
As the guttural pouches are covered by respiratory epithelium and mucosa, they have the potential to be affected by all ... Arabian horse Equine respiratory system Cranial nerves Hyrax Perissodactyls Circle of Willis Pollock, P. J. (2007). "Diagnosis ... respiratory pathogens. Most infections are self-limiting, requiring no or little medical intervention. Upon endoscopy, affected ...
Globalization and disease
... pneumoniae infection may destroy respiratory mucosal cells and facilitate the penetration of antigens into the mucosa. A study ... These viral respiratory infections are mostly caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV). Although ... It may cause injury to the respiratory epithelial cell after its attachment. The injury of host epithelial cells caused by M. ... 2007), M. pneumonia can persist in the respiratory tract up to several months after recovery from acute pneumonia. In fact, M. ...
Gierke respiratory bundle (Named for German anatomist Hans Paul Bernhard Gierke). Krause respiratory bundle (Named for German ... Taste buds in the mucosa of the tongue can also generate impulses in the rostral regions of the solitary tract. The efferent ... respiratory, and intestinal tracts. Afferent fibers from cranial nerves 7, 9 and 10 convey taste (SVA) in its rostral portion, ...
Dead space (physiology)
The respiratory dead space". Am. J. Physiol. 154: 405-416. Heller H, Könen-Bergmann M, Schuster K (1999). "An algebraic ... "Relationship between the humidity and temperature of inspired gas and the function of the airway mucosa". Critical Care ... "Respiratory dead space." in Handbook of Physiology. Section 3: Respiration. Vol 1. Wallace O. Fenn and Hermann Rahn (eds). ... Respiratory Physiology: The Essentials. Lippincott Williams & Wilkins; Ninth edition. ISBN 978-1609136406. the Dead space page ...
Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared ... In humans, the nose is located centrally on the face and serves as an alternative respiratory passage especially during ... as well as contributes moisture to integral components of the respiratory system. Capillary structures of the nose warm and ... with the digestive system, and then into the rest of the respiratory system. ...
Methicillin-resistant Staphylococcus aureus
In humans, S. aureus is part of the normal microbiota present in the upper respiratory tract, and on skin and in the gut mucosa ... It's believed that this will improve the outcomes of those with cystic fibrosis and other respiratory infections. A colourised ... People with cystic fibrosis may develop respiratory complications related to MRSA infection. The incidence of MRSA in those ... Schenck, LP; Surette, MG; Bowdish, DM (November 2016). "Composition and immunological significance of the upper respiratory ...
In humans, S. aureus is part of the normal microbiota present in the upper respiratory tract, and on skin and in the gut mucosa ... Schenck, LP; Surette, MG; Bowdish, DM (November 2016). "Composition and immunological significance of the upper respiratory ... respiratory tract, and on the skin. It is often positive for catalase and nitrate reduction and is a facultative anaerobe that ... respiratory infections such as sinusitis, and food poisoning. Pathogenic strains often promote infections by producing ...
In humans, S. aureus is part of the normal microbiota present in the upper respiratory tract, and on skin and in the gut mucosa ... The lung microbiota (or pulmonary microbial community) is a complex variety of microbes found in the lower respiratory tract ... They are known to cause respiratory disorders under particular conditions namely if the human immune system is impaired. The ... Macromolecular components of respiratory secretions (proteins, glycoproteins, lipids, nucleic acids) are converted to nutrients ...
Inflammatory reaction (e.g. acute respiratory tract infections, chronic sinusitis, rhinitis or environmental irritants) ... Nosebleeds are due to the rupture of a blood vessel within the richly perfused nasal mucosa. Rupture may be spontaneous or ... Spontaneous epistaxis is more common in the elderly as the nasal mucosa (lining) becomes dry and thin and blood pressure tends ... Application of a topical antibiotic ointment to the nasal mucosa has been shown to be an effective treatment for recurrent ...
Ndryshimi mes inspektimeve të "Përdoruesi:Tiimiii/I ftohti i zakonshem"
... colds are defined as upper respiratory tract infections that affect the predominantly nasal part of the respiratory mucosa,via ... Supplementation on Upper Respiratory Tract Infections in Healthy Adults: The VIDARIS Randomized Controlled Trial,/subtitle,,url ... The economic burden of non-influenza-related viral respiratory tract infection in the United States,url=,journal=Arch. Intern. ... Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American ...
Ciliated pseudostratified columnar (respiratory epithelium). Roof of pharynx Palatine tonsils. Non-keratinized stratified ... and the mucosa-associated lymphoid tissue (MALT). Other viewpoints treat them (and the spleen and thymus) as large lymphatic ... Ciliated pseudostratified columnar (respiratory epithelium). Incompletely encapsulated. No crypts, but small folds. Roof of ... Kato A et al, B-lymphocyte lineage cells and the respiratory system, Journal of Allergy and Clinical Immunology, Volume 131, ...
Areas normally affected are lips, buccal mucosa, gingivae, frenum and tongue. The most common injuries are lips and gingivae. ... Higher risk of dislodging during contact sports and airway occlusion which may lead to respiratory distress ... The facial nerve and parotid duct should be examined for any potential damage when the buccal mucosa is involved. ... Facial nerve should be examined for any potential damage when buccal mucosa is involved. ...
Acute inhalation injury
Irritant gases are those that, on inhalation, dissolve in the water of the respiratory tract mucosa and provoke an inflammatory ... When inhaled the vapor produces a direct inflammatory effect on the respiratory tract. Respiratory damage is related to the ... 1998) Persistent respiratory effects in survivors of the Bhopal disaster. Thorax 53:S43-6. Demnati R, Fraser R, Ghezzo H, ... The most common cause of death in burn centers is now respiratory failure. The September 11 attacks in 2001 and forest fires in ...
Granulomatosis with polyangiitis
In general, rhinitis is the first sign in most people. Involvement of the upper respiratory tract, such as the nose and ... non-specific ulcerations throughout oral mucosa ... Death usually resulted from uremia or respiratory failure. ... and medium-size vessels in many organs but most commonly affects the upper respiratory tract and the kidneys. Therefore, the ...
Olfactory ensheathing cells
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bats, pangolins, felines, minks respiratory transmission 2019 ... Contact of mucosae or wounds with feces of kissing bugs. Accidental ingestion of parasites in food contaminated by bugs or ... Severe acute respiratory syndrome SARS coronavirus bats, civets close contact, respiratory droplets ... Middle East respiratory syndrome MERS coronavirus bats, camels close contact Monkeypox Monkeypox virus rodents, primates ...
Human digestive system
The pharynx is a part of the conducting zone of the respiratory system and also a part of the digestive system. It is the part ... Within its mucosa are millions of embedded gastric glands. Their secretions are vital to the functioning of the organ. ... Most of the oral cavity is lined with oral mucosa, a mucous membrane that produces a lubricating mucus, of which only a small ... The palate is hard at the front of the mouth since the overlying mucosa is covering a plate of bone; it is softer and more ...
Remarkably, the IgA1 that accumulates in the kidney does not appear to originate from the mucosa-associated lymphoid tissue ( ... In children and younger adults, the history and association with respiratory infection can raise the suspicion of IgA ... which usually starts within a day or two of a non-specific upper respiratory tract infection (hence synpharyngitic), as opposed ... MALT), which is the site of most upper respiratory tract infections, but from the bone marrow. This, too, suggests an immune ...
Edema of the gastrointestinal mucosa typically leads to severe abdominal pain; in the upper respiratory tract, it can be life- ... The skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue, swell over ... Tracheal intubation is required in these situations to prevent respiratory arrest and risk of death. ...
ಅಲರ್ಜಿ - ವಿಕಿಪೀಡಿಯ
Once inhaled, variola major virus invaded the oropharyngeal (mouth and throat) or the respiratory mucosa, migrated to regional ... Respiratory complications tend to develop on about the eighth day of the illness and can be either viral or bacterial in origin ... Complications of smallpox arise most commonly in the respiratory system and range from simple bronchitis to fatal pneumonia. ... or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to- ...
Respiratory dysfunction (in the absence of a cyanotic heart defect or a known chronic respiratory disease) *the ratio of the ... In the gastrointestinal tract, increased permeability of the mucosa alters the microflora, causing mucosal bleeding and ... Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ...
Lower respiratory infections include various pneumonias, influenzas and acute bronchitis. *^ Diarrheal diseases are caused by ... Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, ... Respiratory tract infection. *Odontogenic infection (an infection that originates within a tooth or in the closely surrounding ... Droplet contact, also known as the respiratory route, and the resultant infection can be termed airborne disease. If an ...
In the human female, the urethra is about 1.9 inches (4.8 cm) to 2 inches (5.1 cm) long and exits the body between the clitoris and the vagina, extending from the internal to the external urethral orifice. The meatus is located below the clitoris. It is placed behind the symphysis pubis, embedded in the anterior wall of the vagina, and its direction is obliquely downward and forward; it is slightly curved with the concavity directed forward. The proximal 2/3rds is lined by transitional epithelium cells while distal 1/3rd is lined by stratified squamous epithelium cells. The urethra consists of three coats: muscular, erectile, and mucous, the muscular layer being a continuation of that of the bladder. Between the superior and inferior fascia of the urogenital diaphragm, the female urethra is surrounded by the urethral sphincter. Somatic (conscious) innervation of the external urethral sphincter is supplied by the pudendal nerve. ...
Upper gastrointestinal series
Barium contrast is more sensitive in the demonstration of subtle mucosa and sub-mucosa abnormalities but computer tomography is ... Aspiration or inhalation of barium sulfate into the lungs during oral application can lead to serious respiratory complications ... and atrophy of the overlying mucosa. Schistosomiasis caused by infection with flatworms have an appearance resembling ...
Of these, 93% reported being ill in the three weeks preceding the onset of Reye's syndrome, most commonly with a respiratory ... "Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy ... "Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa" ...
කොවිඩ්-19 - විකිපීඩියා
Respiratory system/. acute viral nasopharyngitis/. viral pneumonia. DNA virus. *Epstein-Barr virus *EBV infection/Infectious ... "High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa". International Journal of Oral Science ... කොවිඩ්-19 එසේත් නැත්නම් කොරෝනා වෛරස් රෝගය 2019 (ඉංග්රීසි: Coronavirus disease 2019, COVID-19) යනු severe acute respiratory ... රෝගය පුද්ගලයෙකුගෙන් පුද්ගලයෙකුට පැතිරෙන්නේ බොහෝවිට කහින විට ඇතිවන බිඳිති (respiratory droplets) හරහා ය. එසේම ආසාදිත ...
The pink color of the esophageal mucosa contrasts to the deeper red of the gastric mucosa, and the mucosal transition ... The mucosa is a stratified squamous epithelium of around three layers of squamous cells, which contrasts to the single layer of ... The wall of the oesophagus from the lumen outwards consists of mucosa, submucosa (connective tissue), layers of muscle fibers ... protecting the esophageal mucosa. In addition, the acute angle of His and the lower crura of the diaphragm helps this ...
The cross-current respiratory gas exchanger in the lungs of birds. Air is forced from the air sacs unidirectionally (from right ... The digestion products are then absorbed through the intestinal mucosa into the blood. The intestine ends via the large ... Respiratory air sacs often form air pockets within the semi-hollow bones of the bird's skeleton. ... In comparison to the mammalian respiratory tract, the dead space volume in a bird is, on average, 4.5 times greater than it is ...
Cysteinyl leukotriene receptor 2
Sensory nervous system
The gustatory cortex is the primary receptive area for taste. The word taste is used in a technical sense to refer specifically to sensations coming from taste buds on the tongue. The five qualities of taste detected by the tongue include sourness, bitterness, sweetness, saltiness, and the protein taste quality, called umami. In contrast, the term flavor refers to the experience generated through integration of taste with smell and tactile information. The gustatory cortex consists of two primary structures: the anterior insula, located on the insular lobe, and the frontal operculum, located on the frontal lobe. Similarly to the olfactory cortex, the gustatory pathway operates through both peripheral and central mechanisms.[clarification needed] Peripheral taste receptors, located on the tongue, soft palate, pharynx, and esophagus, transmit the received signal to primary sensory axons, where the signal is projected to the nucleus of the solitary tract in the medulla, or the gustatory nucleus of ...
Research Publications- Respiratory System | Respiratory Mucosa
Respiratory mucosa | definition of respiratory mucosa by Medical dictionary
What is respiratory mucosa? Meaning of respiratory mucosa medical term. What does respiratory mucosa mean? ... Looking for online definition of respiratory mucosa in the Medical Dictionary? respiratory mucosa explanation free. ... tunica mucosa tracheae [TA]), and mucosa of bronchi [TA] (tunica mucosa bronchi [TA]). See: respiratory region of mucosa of ... it includes the respiratory region of the nasal mucosa [TA] (pars respiratoria tunicae mucosae nasi [TA]), mucosa of the ...
Respiratory Mucosa | Blausen Medical
Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa. -...
Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa.. ... the balance between host defenses and microbial virulence as it has coevolved to maintain the health of the respiratory mucosa. ... S. pneumoniae do not bind to mucins but attach to respiratory tract epithelial cells. Attachment is increased by viral ... Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. H. influenzae attach to ...
Penetration of erythromycin through respiratory mucosa : a study using secretory otitis media as a model (Book, 1979) [WorldCat...
Penetration of erythromycin through respiratory mucosa : a study using secretory otitis media as a model. [L Sundberg;] ... Penetration of erythromycin through respiratory mucosa : a study using secretory otitis media as a model. Author:. L Sundberg. ... schema:name "Penetration of erythromycin through respiratory mucosa : a study using secretory otitis media as a model"@en ;. ... Add tags for "Penetration of erythromycin through respiratory mucosa : a study using secretory otitis media as a model". Be the ...
Upper airway mucosa temperature in obstructive sleep apnoea/hypopnoea syndrome, nonapnoeic snorers and nonsnorers | European...
Your Name) has sent you a message from European Respiratory Society Message Body (Your Name) thought you would like to see the ... Upper airway mucosa temperature in obstructive sleep apnoea/hypopnoea syndrome, nonapnoeic snorers and nonsnorers. F Series, I ... European Respiratory Society. 442 Glossop Road. Sheffield S10 2PX. United Kingdom. Tel: +44 114 2672860. Email: [email protected] ... Upper airway mucosa temperature in obstructive sleep apnoea/hypopnoea syndrome, nonapnoeic snorers and nonsnorers ...
Respiratory region of tunica mucosa of nose | definition of respiratory region of tunica mucosa of nose by Medical dictionary
What is respiratory region of tunica mucosa of nose? Meaning of respiratory region of tunica mucosa of nose medical term. What ... respiratory region of tunica mucosa of nose explanation free. ... does respiratory region of tunica mucosa of nose mean? ... Looking for online definition of respiratory region of tunica mucosa of nose in the Medical Dictionary? ... respiratory region of mucosa of nasal cavity. (redirected from respiratory region of tunica mucosa of nose) respiratory region ...
Crosssection Of A Bronchiole In The Respiratory Tract Showing Its Folded Mucosa And The Surrounding Thinwalled Alveoli Through...
Nasal mucosa and blood cell transcriptome profiles do not reflect respiratory symptoms associated with moisture damage
In a next step, bovine respiratory and genital mucosa explants of the same animals were inoculated with several BoHV-1 subtypes ... In a next step, bovine respiratory and genital mucosa explants of the same animals were inoculated with several BoHV-1 subtypes ... In a next step, bovine respiratory and genital mucosa explants of the same animals were inoculated with several BoHV-1 subtypes ... a Comparative analysis of replication characteristics of BoHV-1 subtypes in bovine respiratory and genital mucosa explants: a ...
The US3 protein of pseudorabies virus drives viral passage across the basement membrane in porcine respiratory mucosa explants
Here, using an ex vivo system of porcine nasal respiratory mucosa explants that allows to study PRV invasion through the BM, we ... Here, using an ex vivo system of porcine nasal respiratory mucosa explants that allows to study PRV invasion through the BM, we ... Here, using ex vivo porcine respiratory mucosa explants, we show that the conserved US3 protein of the porcine alphaherpesvirus ... Here, using ex vivo porcine respiratory mucosa explants, we show that the conserved US3 protein of the porcine alphaherpesvirus ...
HKU Scholars Hub: Pseudomonas aeruginosa pyocyanin: discruption of ultrastructure of human respiratory mucosa in vitro
Method The human respiratory mucosa was obtained without anaesthetic from the inferior turbinate of 6 healthy subjects, and ... Method The human respiratory mucosa was obtained without anaesthetic from the inferior turbinate of 6 healthy subjects, and ... Conference Paper: Pseudomonas aeruginosa pyocyanin: discruption of ultrastructure of human respiratory mucosa in vitro. *Show ... Pseudomonas aeruginosa pyocyanin: discruption of ultrastructure of human respiratory mucosa in vitro. en_HK. ...
KAKEN - Research Projects | Relationship between asthmatic respiratory inflammation and abnormal secretion of olfactory mucosa...
Oral respiratory Nitric acid (FeNO) was found high concentrations in respiratory mucosa with remarkable infiltrative ... Not only cilia damage of the respiratory sinus mucosa, but also olfactory cilia damage and highly secretion of Bowman gland ... Relationship between asthmatic respiratory inflammation and abnormal secretion of olfactory mucosa-effect of olfactory ... On the other hand, histopathological eosinophilic infiltration in anterior portion of sinus respiratory mucosa significantly ...
PR-39, a porcine host defence peptide, is prominent in mucosa and lymphatic tissue of the respiratory tract in healthy pigs...
PR-39, a porcine host defence peptide, is prominent in mucosa and lymphatic tissue of the respiratory tract in healthy pigs and ... PR-39, a porcine host defence peptide, is prominent in mucosa and lymphatic tissue of the respiratory tract in healthy pigs and ... PR-39 was found in all tissue samples of the upper respiratory tract in healthy and diseased pigs. Within the tracheobronchial ... Keywords: Swine; Innate immunity; Cathelicidin; Antibacterial peptide; Pleuropneumonia; Respiratory tract. Journal: BMC ...
Light and electron microscopic studies on the submucosal glands of respiratory nasal mucosa in calves experimentally infected...
Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa...
... we undertook a transcriptional profiling study of the nasal mucosa over the course of acute respiratory illness amongst ... We found that acute respiratory illness is characterized by dynamic, time-specific transcriptional profiles whose magnitudes of ... To address the deficiencies in our understanding of the molecular events characterizing acute respiratory illness-induced ... Time point-based microarray and principal component analyses were conducted to identify and distinguish acute respiratory ...
Respiratory Mucosa | Profiles RNS
"Respiratory Mucosa" by people in this website by year, and whether "Respiratory Mucosa" was a major or minor topic of these ... The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous ... "Respiratory Mucosa" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Respiratory Mucosa" by people in Profiles. ...
Respiratory System Anatomy: What Happens to Air When You Breathe In?
Many people only know the basics of respiratory system anatomy. Read more about the lungs and the alveoli where gas exchange ... These hollow sections of the skull are lined with the same mucosa as other parts of the respiratory system. They warm and ... About the Respiratory System. The human respiratory system is the primary means through which gas exchange occurs in the body. ... Learn more about the respiratory system anatomy. How does air cycle through the respiratory system and where does gas exchange ...
A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production -...
Upper Respiratory Tract Infections Intervention ICMJE *Drug: PrEP-001 6.4 mg 6.4 mg as 4 sprays per nostril (ie total of 8 ... A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production. ... A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production ... Has experienced upper or lower respiratory infection (viral, fungal or bacterial) that resolved less than 4 weeks before Day 1 ...
GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa | PNAS
2015) Respiratory epithelial cells orchestrate pulmonary innate immunity. Nat Immunol 16(1):27-35. ... Whereas the oral mucosa of Gas6+/+ mice was mainly colonized by bacteria of the Firmicutes phylum, Gas6−/− mice contained three ... 7A, higher expression levels of the noted enzymes were found in the oral mucosa of Gas6−/− compared with Gas6+/+ mice. We next ... S5B). However, the percentages of these cells in the oral mucosa of G→G mice were significantly higher than in W→G mice, in ...
Buccal mucosa numb and Ear burning sensation and Numbness of both ears - Symptom Checker - check medical symptoms at...
List of causes of Buccal mucosa numb and Ear burning sensation and Numbness of both ears, alternative diagnoses, rare causes, ... Respiratory symptoms (5166 causes) *Common symptoms (8589 causes) *Body symptoms (5672 causes) *Breathing symptoms (3381 causes ... Buccal mucosa numb:*Causes: Buccal mucosa numb *Introduction: Buccal mucosa numb *Buccal mucosa numb: Add a 4th symptom *Buccal ... More Searches: Buccal mucosa numb. *Buccal mucosa numb: Add a 4th symptom *Buccal mucosa numb: Remove a symptom *Start with new ...
Buccal mucosa sensitive and Calf numbness and Vaginal burning sensation - Symptom Checker - check medical symptoms at...
List of 21 causes for Buccal mucosa sensitive and Calf numbness and Vaginal burning sensation, alternative diagnoses, rare ... Respiratory symptoms (5166 causes) *Common symptoms (8589 causes) *Body symptoms (5672 causes) *Breathing symptoms (3381 causes ... Buccal mucosa sensitive:*Causes: Buccal mucosa sensitive *Introduction: Buccal mucosa sensitive *Buccal mucosa sensitive: Add a ... Buccal mucosa *Buccal *Mucosa *Sensitive *more symptoms...» Broaden Your Search: Remove a Symptom. *REMOVE Buccal mucosa ...
Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life | Thorax
However, there are few data on DCs in the mucosa of the human respiratory tract in health and disease.6-8 To date, only adult ... BACKGROUND Dendritic cells (DCs) in the mucosa of the respiratory tract might be involved in the early development of pulmonary ... This study extends the knowledge on the first occurrence of DCs in the human respiratory mucosa. The investigation of their ... All infants who had died of respiratory infectious diseases had DCs in the tracheal mucosa. ...
Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa - Volume 27, Number 1-January 2021 - Emerging Infectious Diseases...
Analyses of infection chains have demonstrated that severe acute respiratory syndrome coronavirus 2 is highly transmissive. ... Lipsitch M, Cohen T, Cooper B, Robins JM, Ma S, James L, et al. Transmission dynamics and control of severe acute respiratory ... Upper Respiratory Infections in Schools and Childcare Centers Reopening after COVID-19 Dismissals, Hong Kong Presymptomatic ... Postmortem stability of SARS-CoV-2 in nasopharyngeal mucosa. A) Correlation of SARS-CoV-2 RNA loads of the pharynx (at corpse ...
Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification | European Respiratory Society
Nasal mucosa pathology. Nasal mucosa specimens revealed a chronic subepithelial inflammatory cell infiltration consisting ... As far as the histopathology of the nasal mucosa is concerned, the present study demonstrated an attenuated nasal mucosa ... no upper or lower respiratory tract disease (e.g., upper respiratory tract infection, rhinitis, sinusitis, chronic obstructive ... Your Name) has sent you a message from European Respiratory Society Message Body (Your Name) thought you would like to see the ...
Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa
European Respiratory Journal On the subject. Medical and Health Sciences Search outside of DiVA. GoogleGoogle Scholar. ... 1. Phospholipase A2 expression in the human nasal mucosa. Open this publication in new window or tab ,,Phospholipase A2 ... 2. Phospholipase A2 expression in the human nasal mucosa. Open this publication in new window or tab ,,Phospholipase A2 ... Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa. Lindbom, John Linköping University, ...
Heel Mucosa Compositum on sale at AllStarHealth.com
Mucosa Compositum information including description from Heel, supplement facts, and suggested use. Order online for quick ... Upper respiratory tract Tamper Evident: Use this product only if imprinted shrink seal around neck and cap is intact.. ... Mucosa duodeni 8X, Mucosa ilei 8X, Mucosa jejuni 8X, Mucosa nasalis suis 8X, Mucosa oesophagi 8X, Mucosa oculi 8X, Mucosa oris ... 8X, Mucosa pulmonis 8X, Mucosa pylori 8X, Mucosa recti 8X, Mucosa vesicae felleae 8X, Mucosa vesicae urinariae 8X, Natrum ...
Frontiers | Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with...
Here, we report of implantation of an engineered 3D construct embedded with human oral mucosa stem cells (hOMSC) induced to ... Here, we report of implantation of an engineered 3D construct embedded with human oral mucosa stem cells (hOMSC) induced to ... Rats were anesthetized using 1-3% isoflurane and maintained at 37°C; breathing was monitored with a respiratory sensor (n = 3/ ... 2014). Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo. Stem Cells ...
Respiratory system - Wikipedia
Most of the respiratory system is lined with mucous membranes that contain mucosa-associated lymphoid tissue, which produces ... The Respiratory System University level (Microsoft Word document). *Lectures in respiratory physiology by noted respiratory ... The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs ... In humans and other mammals, the anatomy of a typical respiratory system is the respiratory tract. The tract is divided into an ...
CiNii 論文 - Comparative Studies of Mucosa and Immunoglobulin (Ig)-Containing Plasma Cells in...
Immunohistochemcial study on the distribution of lymphoid tissues in the upper alimentary and respiratory tracts of chickens ... Comparative Studies of Mucosa and Immunoglobulin (Ig)-Containing Plasma Cells in the Gastrointestinal Tract of Broiler and ... The aims of this study was to find out the histological differences of the mucosa and comparative analysis of Ig-containing ... 1. Migration of B Immunoblasts into intestinal respiratory and genital tissues MCDERMOTT MR ...
EpithelialTracheaNasal cavityPathologyAnatomyBronchiolesInfectionsIntestinalTractsInflammationTissueExplantsAirwaySyncytial virusVirusesAirwaysNoseBuccal mucosaGastrointestinal mucosaLungsSquamousUpper respiratoryHistopathological and histochemicalOralThroatTrachealLamina propriaHuman respiratory tractSystemAlveoliInhalationAlveolarTurbinateRespiratoriaSymptomsTracheobronchialSinonasalSyndrome coronavirusOlfactory regionLungBacterial
- Fibro-osseous and respiratory epithelial hamartoma of the fronto-ethmoid region. (molecularstation.com)
- S. pneumoniae do not bind to mucins but attach to respiratory tract epithelial cells. (nih.gov)
- IMPORTANCE : Many viruses, including alphaherpesviruses, primarily replicate in epithelial cells of surface mucosae, such as the respiratory mucosa. (ugent.be)
- Here, using ex vivo porcine respiratory mucosa explants, we show that the conserved US3 protein of the porcine alphaherpesvirus pseudorabies virus (PRV) is critical for passage of PRV across the basement membrane and contributes to efficient viral epithelial spread. (ugent.be)
- The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells. (rush.edu)
- The IgA secreted across the mucosa prevents microbial binding to epithelial cells in the digestive and respiratory tracts. (biomedcentral.com)
- The lining epithelium of respiratory mucosa showed a loss of ciliated cells with metaplasia of goblet cells , hyperplasia of squamous cells and edema , inflamation in sub epithelial area). (bvsalud.org)
- Creative Bioarray provides the most comprehensive list of primary cells and tumor cell line for your researches, including Respiratory cells and lung cell , Human corneal epithelial cells (HCECs) & HCE-T Cell line. (creative-bioarray.com)
- The mammalian nasal passage is lined with four different epithelial populations: squamous, transitional (nonciliated cuboidal/columnar), respiratory, and olfactory epithelium. (aspetjournals.org)
- The epithelial tissue - the tissue covering body surfaces - of the buccal mucosa is characterized as "squamous. (wisegeek.com)
- The epithelial tissue of the buccal mucosa is non-keratinised, which means that these cells have a nucleus, or central generating core, as well as cytoplasm, which consists of all living structures in a cell apart from the nucleus. (wisegeek.com)
- The squamous epithelial tissue of the buccal mucosa area is particularly subject to cancer, and over 90% of oral cancers have been associated with squamous cell carcinomas of the mouth and lip areas. (wisegeek.com)
- METHODS Specimens of the distal trachea from patients who had died from sudden death in the first year of life (n=29) and in older age groups (n=59) as well as from those who had died from respiratory tract infections in the first year of life (n=8) were examined by immunohistochemistry. (bmj.com)
- The earlier generations (approximately generations 0-16), consisting of the trachea and the bronchi, as well as the larger bronchioles which simply act as air conduits , bringing air to the respiratory bronchioles, alveolar ducts and alveoli (approximately generations 17-23), where gas exchange takes place. (wikipedia.org)
- Light micrograph of a section through mucosa of the trachea. (sciencephoto.com)
- In its natural state, the olfactory mucosa lines the roof of the nasal cavity, adjacent to the respiratory mucosa that lines the lower nasal cavity. (thefreedictionary.com)
- Oral respiratory Nitric acid (FeNO) was found high concentrations in respiratory mucosa with remarkable infiltrative eosinophils and high FeNO concentration was imaged to flow from choana into nasal cavity. (nii.ac.jp)
- The nasal mucosa , also known as the mucous membrane and respiratory mucosa, is the tissue that lines the nasal cavity . (wisegeek.com)
- Another way the nasal cavity lining prepares air to enter the respiratory system is by warming it with the heat radiating from the blood vessels within the lamina propria. (wisegeek.com)
- Final pathology of the right-sided lesion revealed mostly dilated vascular channels with unremarkable overlying respiratory mucosa , consistent with a hemangioma (figure 3). (thefreedictionary.com)
- A randomised, crossover, sham-controlled design was adopted, and nasal resistance, nasal wash inflammatory markers and pathology of nasal mucosa were examined in OSA patients using CPAP and exhibiting nasal symptoms. (ersjournals.com)
- Respiratory System Anatomy: What Happens to Air When You Breathe In? (brighthub.com)
- Learn more about the respiratory system anatomy. (brighthub.com)
- The respiratory system anatomy is divided into upper and lower tracts. (brighthub.com)
- In humans and other mammals , the anatomy of a typical respiratory system is the respiratory tract . (wikipedia.org)
- Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. (nih.gov)
- Infants who had died from sudden death (thus excluding the influence of diseases) were compared with a small group of infants who had died of respiratory tract infections. (bmj.com)
- Bacterial infections of respiratory and gastrointestinal mucosae : based on a symposium of the SGM held in September 1987 / edited by W. Donachie, E. Griffiths, J. Stephen. (who.int)
- Acute respiratory infections are responsible for the hospitalization and deaths of millions of individuals annually worldwide 1 . (nature.com)
- Relief of symptoms of mild upper respiratory infections. (globalherbalsupplies.com)
- Rationale HIV-infected adults are at an increased risk of lower respiratory tract infections. (bmj.com)
- This might contribute to the susceptibility of HIV-infected adults to lower respiratory tract infections such as pneumonia and tuberculosis. (bmj.com)
- Respiratory infections are a leading cause of death in lower income countries, accounting for approximately three million deaths a year. (bmj.com)
- Details of the patient's history aid in differentiating a common cold from conditions that require targeted therapy, such as group A streptococcal pharyngitis , bacterial sinusitis, and lower respiratory tract infections. (medscape.com)
- Most people are familiar with nasal mucosa and how it helps keep out infections but few people know that we also require nasal mucus for our sense of smell. (wisegeek.com)
- Mucous membranes line the digestive, respiratory, and reproductive tracts and are the primary barrier between the external world and the interior of the body. (creative-bioarray.com)
- Moist layer of tissue lining the body's openings, including the genital/urinary and anal tracts, the gut and the respiratory tract. (aidsmap.com)
- A membrane lining all body passages that communicate with the air, such as the respiratory and alimentary tracts, and having cells and associated glands that secrete mucus. (thefreedictionary.com)
- Any of the membranes lining the passages of the body that open onto the outside, such as the respiratory and digestive tracts. (thefreedictionary.com)
- Therefore, olfactory dysfunction in eosinophilic sinusitis was thought to be affected by lower respiratory tract inflammation. (nii.ac.jp)
- The precise roles of the different PLA 2 enzymes in airways inflammation are not known and the gene expression of the different PLA 2 s in the human nasal mucosa has not previously been examined. (diva-portal.org)
- Sites of systemic absorption include broken skin tissue, inflamed gastric sites, eczematous skin and respiratory mucosa with the risk of a reaction increasing with number and duration of sprays administered. (thefreedictionary.com)
- We established bovine respiratory and genital organ cultures with emphasis on maintenance of tissue morphology and viability during in vitro culture. (ugent.be)
- All BoHV-1 subtypes exhibited a more profound invasion capacity in respiratory tissue compared to that in genital tissue at 24 h pi. (ugent.be)
- However, at 24 h pi plaque latitude was found to be larger in genital tissue compared to respiratory tissue and this for all subtypes. (ugent.be)
- PR-39 was found in all tissue samples of the upper respiratory tract in healthy and diseased pigs. (k-state.edu)
- Creative Bioarray's in vitro airway tissue model could be applied to in vitro respiratory toxicity testing, it is very similar to in vivo airway mucosa in terms of morphology, of differentiation markers and of functional characteristics. (creative-bioarray.com)
- For a number of species, including nonhuman primates, nasal tissue, especially olfactory mucosa, contains high concentrations of P450s. (aspetjournals.org)
- The nasal mucosa is moist tissue that secretes mucous. (wisegeek.com)
- The mucous produced by the nasal mucosa is the body's answer to the vulnerability of exposed internal tissue. (wisegeek.com)
- It is lined by a ciliated pseudostratified columnar epithelium (respiratory epithelium) resting on a connective tissue lamina propria. (sciencephoto.com)
- In a next step, bovine respiratory and genital mucosa explants of the same animals were inoculated with several BoHV-1 subtypes. (ugent.be)
- Steukers L, Vandekerckhove A, Van Den Broeck W, Glorieux S, Nauwynck H. Comparative analysis of replication characteristics of BoHV-1 subtypes in bovine respiratory and genital mucosa explants: a phylogenetic enlightenment. (ugent.be)
- Exposure of formalin above permissible limit may create physiological modifications of respiratory mucosa , which causes upper airway irritation, sore throat, tingling and burning sensations of the nose and nasal blockage. (thefreedictionary.com)
- Increased airway mucins after cardiopulmonary bypass associated with postoperative respiratory complications in children. (rush.edu)
- Secretory Immunoglobulins A (SIgA) play a key role in the elaboration of the immunological response at the level of the upper respiratory airway, challenging allergens or pathogenic micro organisms. (biomedcentral.com)
- Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. (yale.edu)
- The lung is a critical prophylaxis target for clinically important infectious agents, including human respiratory syncytial virus (RSV) and influenza. (nature.com)
- Additionally, prophylaxis remains limited to antivirals and, in the case of respiratory syncytial virus (RSV), the broadly neutralizing antibody palivizumab is the only FDA approved treatment for high-risk populations. (nature.com)
- Influenza A viruses of the H9N2 subtype are endemic in poultry in many Eurasian countries and have occasionally caused clinical respiratory diseases in. (molecularstation.com)
- In fact, distributed on the mucous film lining the respiratory epithelium, SIgA neutralize viruses and bacterial surface antigens, favouring their phagocytosis. (biomedcentral.com)
- Respiratory illnesses that are airborne such as cold and flu viruses will spread rapidly from person to person due to lack of hygiene and lowered immune systems. (secretsofsurvival.com)
- Influenza viruses target respiratory mucosa. (aafp.org)
- Respiratory viruses and asthma. (biomedsearch.com)
- Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. (yale.edu)
- However, the precise contribution of different PLA 2 types to the formation of inflammatory lipid mediators in the upper airways is not known and the expression of different PLA 2 genes in the human nasal mucosa has not been examined. (diva-portal.org)
- The branching airways of the lower tract are often described as the respiratory tree or tracheobronchial tree (Fig. 2). (wikipedia.org)
- The airways of the respiratory tract offer resistance to the flow of air during inhalation and expiration. (reprocell.com)
- The principle of this procedure is the substitution of the fragile respiratory mucosa of the nose with strong skin grafts (generally from the thigh or oral mucosa) that withstand trauma and, thus, avoid bleeding. (thefreedictionary.com)
- Moreover, this investigation demonstrates, for the first time, the presence of the newly discovered phospholipase A 2 forms IID, IIE, III, IVB, IVC, X and calcium-independent membrane bound phospholipase A 2 in the human nasal mucosa and raises the possibility that one or several of these may be involved in inflammatory reactions in the nose. (diva-portal.org)
- A similar type of membrane also lines the exterior entrances to the respiratory system at the nose and throat areas. (wisegeek.com)
- See detailed information below for a list of 6 causes of Buccal mucosa numb , Symptom Checker , including diseases and drug side effect causes. (rightdiagnosis.com)
- The following medical conditions are some of the possible causes of Buccal mucosa numb. (rightdiagnosis.com)
- Listed below are some combinations of symptoms associated with Buccal mucosa numb, as listed in our database. (rightdiagnosis.com)
- Review further information on Buccal mucosa numb Treatments . (rightdiagnosis.com)
- Read more about causes and Buccal mucosa numb deaths . (rightdiagnosis.com)
- How Common are these Causes of Buccal mucosa numb? (rightdiagnosis.com)
- This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Buccal mucosa numb. (rightdiagnosis.com)
- The following list of conditions have ' Buccal mucosa numb ' or similar listed as a symptom in our database. (rightdiagnosis.com)
- pathological conditions associated with the buccal mucosa. (rightdiagnosis.com)
- What is the Buccal Mucosa? (wisegeek.com)
- The buccal mucosa is a specific area of the oral mucosa - a mucous membrane covering the mouth area. (wisegeek.com)
- The buccal mucosa area of this membrane extends around the inside of the cheek and lower mouth area, the bottom of the tongue, out to the lips and to the back of the throat. (wisegeek.com)
- The parotid gland, a large gland that produces saliva for the mouth as an aid in digestion, flows into an area of the buccal mucosa near the second upper molar, known as the buccal cavity or the inner surface of the buccal mucosa. (wisegeek.com)
- While the soft palate is part of the buccal mucosa, however, it does not continue on to extend up to the roof of the mouth, which is an area known as the hard palate. (wisegeek.com)
- In land animals the respiratory surface is internalized as linings of the lungs . (wikipedia.org)
- Respiratory portion - tissues w/in lungs where gas exchange occurs. (brainscape.com)
- Nevertheless, exposure of the lungs to various components of the e-cigarette aerosol could potentially damage the respiratory system or worsen preexisting lung disease through a variety of mechanisms (see Figure 11-1 ). (nap.edu)
- Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. (thefreedictionary.com)
- Examination of the nasal mucosa showed several ultrastructural changes in those exposed to passive smoke, including patchy loss of cilia, generalized loss of cilia, squamous metaplasia, hyperplasia of goblet cells and seromucinous acini and vascular congestion. (enttoday.org)
- In general, members of the Alphaherpesvirinae use the epithelium of the upper respiratory and/or genital tract as a preferential site for primary replication. (ugent.be)
- It has been hypothesized that subtype 1.1 invades preferentially the upper respiratory mucosa whereas subtype 1.2 favors replication at the peripheral genital tract. (ugent.be)
- The upper respiratory system is composed of what parts? (brainscape.com)
- Upper respiratory diseases (URDs) -- Maximum Time Interval is 5 years. (cdc.gov)
- Environmental tobacco smoke (ETS) is most in the upper respiratory tract. (cdc.gov)
Histopathological and histochemical1
- Here, we report of implantation of an engineered 3D construct embedded with human oral mucosa stem cells (hOMSC) induced to secrete neuroprotective, immunomodulatory, and axonal elongation-associated factors, in a complete spinal cord transection rat model. (frontiersin.org)
- Creative Bioarray's in vitro Oral Mucosa model could be applied to in vitro oral irritation, toxicity, tolerance test, and in vitro dental material assessment. (creative-bioarray.com)
- Oral mucosa irritation test, Safety Evaluation on dental Materials, Oral mucosa toxicity test, Gingival mucosa toxicity test, or any customized in vitro assays available at Creative Bioarray. (creative-bioarray.com)
- All infants who had died of respiratory infectious diseases had DCs in the tracheal mucosa. (bmj.com)
- This study focused on the presence of DCs in the tracheal mucosa in the first year of life. (bmj.com)
- Be the first to review Drug Discovery Assay Services Assay: Ion channel function in healthy human tracheal mucosa (Adrenoceptors). (reprocell.com)
- This assay asseses whether a test compound causes a change in short circuit current across healthy human tracheal mucosa with isoprenaline as a reference compound. (reprocell.com)
- Tracheal intubation is required in these situations to prevent respiratory arrest and risk of death. (wikipedia.org)
- Describe the lamina propria in the olfactory region and in the respiratory region? (brainscape.com)
- Among these, the olfactory mucosa (i.e., the olfactory epithelium and its underlying lamina propria) contains four primary cells: the duct cells lining Bowman's glands, basal cells, olfactory receptor cells, and the sustentacular cells or olfactory supporting cells. (aspetjournals.org)
Human respiratory tract3
- Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa. (nih.gov)
- However, there are few data on DCs in the mucosa of the human respiratory tract in health and disease. (bmj.com)
- Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome. (nih.gov)
- How does air cycle through the respiratory system and where does gas exchange occur? (brighthub.com)
- The gas exchange function of the respiratory system expels these wastes away from the body. (brighthub.com)
- The respiratory system is also responsible for the production of sound and aids in balancing the pH balance of the blood. (brighthub.com)
- These hollow sections of the skull are lined with the same mucosa as other parts of the respiratory system. (brighthub.com)
- A complete, schematic view of the human respiratory system with their parts and functions. (wikipedia.org)
- The respiratory system (also respiratory apparatus , ventilatory system ) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants . (wikipedia.org)
- In most fish , and a number of other aquatic animals (both vertebrates and invertebrates ) the respiratory system consists of gills , which are either partially or completely external organs, bathed in the watery environment. (wikipedia.org)
- The respiratory system in plants includes anatomical features such as stomata , that are found in various parts of the plant. (wikipedia.org)
- What are the functions of the respiratory system? (brainscape.com)
- What are the components of the respiratory system? (brainscape.com)
- The lower respiratory system is composed of what parts? (brainscape.com)
- What are the two functional divisions of the respiratory system? (brainscape.com)
- Another major function of the nasal mucosa is conditioning the air for entrance into the rest of the respiratory system. (wisegeek.com)
- The mucous within the nasal mucosa not only serves to remove bacteria from the air entering the respiratory system, but it also humidifies, or adds moisture, to the air. (wisegeek.com)
- These fluids are necessary to prevent drying effects, since this mucosa is part of the membrane system that lines the entire gastrointestinal tract, and this is open to exterior surfaces at both ends. (wisegeek.com)
- Currently there is a lack of information regarding the short- and long-term effects of e-cigarettes on the respiratory system. (nap.edu)
- Individuals may be exposed to toxic metals present in the environment via multiple routes, such as the respiratory tract through inhalation of air pollution [ 1 ], or orally by ingestion of contaminated food and water [ 2 ]. (hindawi.com)
- An MRL of 0.003 ppm has been derived be at a higher risk of developing adverse heating of animal and vegetable fats and for acute-duration inhalation exposure respiratory responses when exposed to a Dermal - Minor route of exposure. (cdc.gov)
- Figure 1: Cumulative concentration response curve to isoprenaline in isolated human lung mucosa, demonstrating a concentration dependent increase in Isc in the presence of increasing concentrations of isoprenaline. (reprocell.com)
- A 76-year old male with an adenocarcinoma of unknown primary origin in the lung presented with another tumor of the palate mucosa. (springer.com)
- This result suggested that origins of the tumors of the palate mucosa and in the lung were the same, even though the origin had not yet been determined. (springer.com)
- This result indicated that the primary site of the CUP was indeed the lung, and that the tumor of the palate mucosa was a metastasis of the LUAD. (springer.com)