Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
Surgical formation of an opening into the trachea through the neck, or the opening so created.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.
The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Measurement of oxygen and carbon dioxide in the blood.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.
Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.
The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.
Pathological processes involving any part of the LUNG.
Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
An infant during the first month after birth.
Relatively complete absence of oxygen in one or more tissues.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Elements of limited time intervals, contributing to particular results or situations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Failure of the SOFT PALATE to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (ADENOIDECTOMY; CLEFT PALATE) or an incompetent PALATOPHARYNGEAL SPHINCTER. It is characterized by hypernasal speech.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Skin breakdown or ulceration caused by VARICOSE VEINS in which there is too much hydrostatic pressure in the superficial venous system of the leg. Venous hypertension leads to increased pressure in the capillary bed, transudation of fluid and proteins into the interstitial space, altering blood flow and supply of nutrients to the skin and subcutaneous tissues, and eventual ulceration.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
The study and treatment of defects in binocular vision resulting from defects in the optic musculature or of faulty visual habits. It involves a technique of eye exercises designed to correct the visual axes of eyes not properly coordinated for binocular vision.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)

Autosomal dominant myopathy with proximal weakness and early respiratory muscle involvement maps to chromosome 2q. (1/1819)

Two Swedish families with autosomal dominant myopathy, who also had proximal weakness, early respiratory failure, and characteristic cytoplasmic bodies in the affected muscle biopsies, were screened for linkage by means of the human genome screening set (Cooperative Human Linkage Center Human Screening Set/Weber version 6). Most chromosome regions were completely excluded by linkage analysis (LOD score <-2). Linkage to the chromosomal region 2q24-q31 was established. A maximum combined two-point LOD score of 4.87 at a recombination fraction of 0 was obtained with marker D2S1245. Haplotype analysis indicated that the gene responsible for the disease is likely to be located in the 17-cM region between markers D2S2384 and D2S364. The affected individuals from these two families share an identical haplotype, which suggests a common origin.  (+info)

Outcome for cancer patients requiring mechanical ventilation. (2/1819)

PURPOSE: To describe hospital survival for cancer patients who require mechanical ventilation. MATERIALS AND METHODS: A prospective, multicenter observational study was performed at five academic tertiary care hospitals. Demographic and clinical variables were obtained on consecutive cancer patients at initiation of mechanical ventilation, and information on vital status at hospital discharge was acquired. RESULTS: Our analysis was based on 782 adult cancer patients who met predetermined inclusion criteria. The overall observed hospital mortality was 76%, with no statistically significant differences among the five study centers. Seven variables (intubation after 24 hours, leukemia, progression or recurrence of cancer, allogeneic bone marrow transplantation, cardiac arrhythmias, presence of disseminated intravascular coagulation, and need for vasopressor therapy) were associated with an increased risk of death, whereas prior surgery with curative intent was protective. The predictive model based on these variables had an area under the receiver operating characteristic curve of 0.736, with Hosmer-Lemeshow goodness-of-fit statistics of 7.19; P = .52. CONCLUSION: This model can be used to estimate the probability of hospital survival for classes of adult cancer patients who require mechanical ventilation and can help to guide physicians, patients, and families in deciding goals and direction of treatment. Prospective independent validation in different medical settings is warranted.  (+info)

Effects of acute prolonged exposure to high-altitude hypoxia on exercise-induced breathlessness. (3/1819)

The direct effects of hypoxia on exercise-induced breathlessness are unclear. Increased breathlessness on exercise is known to occur at high altitude, but it is not known whether this is related to the hypoxia per se, or to other ventilatory parameters. To examine the role of high-altitude hypoxia in exercise-induced breathlessness, studies were performed in 10 healthy, normal subjects at sea level and after acute exposure to an altitude of 4450 m. Although the perception of hand weights did not alter between sea level and high altitude, the intensity of exercise-induced breathlessness increased significantly at high altitude. This was associated with a higher minute ventilation and respiratory frequency for any given exercise level, whereas tidal volume was not significantly altered from sea level values. The increased intensity of breathlessness with exercise did not change significantly over the 5 days at high altitude. These results suggest that the increased intensity of exercise-induced breathlessness at high altitude is not related to peripheral mechanisms or the pattern of ventilation, or to the level of hypoxia per se, but to the level of reflexly increased ventilation.  (+info)

Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. (4/1819)

OBJECTIVE: To retrospectively analyze the clinical symptoms, laboratory findings, and outcomes in patients with microscopic polyangiitis (MPA) who were enrolled in various clinical trials conducted by the French Vasculitis Study Group. METHODS: A cohort of 85 patients meeting the Chapel Hill criteria for MPA participated in the study. Seventy-one of them were included in prospective therapeutic trials. Eighty-one diagnoses were biopsy proven. In the other patients, diagnosis was based on clinical findings. RESULTS: Forty-seven men and 38 women, with a mean +/- SD age of 56.8 +/- 14.6 years, met the criteria for MPA. Their main clinical symptoms were renal manifestations (78.8%), weight loss (72.9%), skin involvement (62.4%), fever (55.3%), mononeuritis multiplex (57.6%), arthralgias (50.6%), myalgias (48.2%), hypertension (34.1%), lung involvement (24.7%; alveolar hemorrhage 11.8%), and cardiac failure (17.6%). The mean +/- SD serum creatinine level before treatment was 2.59 +/- 2.96 mg/dl; 47 patients had renal insufficiency (serum creatinine > 1.36 mg/dl). Eight patients underwent dialysis at the time of diagnosis, and long-term dialysis was necessary for 10 patients. Antineutrophil cytoplasmic antibodies (ANCA) were present in 38 of 51 patients (74.5%), of whom 33 had a perinuclear staining pattern (pANCA) and 5 had a cytoplasmic pattern. Antibodies to proteinase 3 were present in 4 patients and antibodies to myeloperoxidase were detected in 31, as determined by enzyme-linked immunosorbent assay. Of the 30 patients who underwent renal and celiac angiography, 4 had microaneurysms. Of the 29 patients (34.1%) who had relapses, 8 died during or after the relapse. During followup, 28 of the 85 patients (32.9%) died. The mean +/- SD duration of followup of the group was 69.9 +/- 60.6 months. Deaths were less frequent when patients had been treated with steroids and immunosuppressive drugs (13 patients [24.1%]) than with steroids alone (15 patients [48.4%]) (P < 0.01). The 5-year survival rate was 74%. CONCLUSION: This study demonstrated that MPA is a multisystemic disease in which renal symptoms are frequent, but the disease is also associated with general symptoms, arthritis, mononeuritis multiplex, and other manifestations that are also seen in various vasculitides. The rarity of abnormal angiogram findings and the high frequency of pANCA are characteristic of MPA. In most cases, the outcome is comparable with those of other systemic vasculitides, but relapses are frequent.  (+info)

Frequency of arrhythmias and other cardiac abnormalities in fulminant hepatic failure. (5/1819)

In a series of 106 patients with fulminant hepatic failure and grade 4 encephalopathy, cardiac arrhythmias and other abnormalities occurred in 92 per cent. The most common was sinus tachycardia (75%) and this was the only abnormality in 22 per cent of the patients. Sudden cardiac arrest occurred in 25 per cent, various ectopic beats in 20 per cent, and heart block or bradycardia in 18 per cent. Other electrocardiographic abnormalities, mostly of the T wave and ST segment, were found in 31 per cent. Cardiac and respiratory arrests were usually unrelated to each other and both frequently occurred without warning. Only 7 out of 71 patients with arrhythmias other than sinus tachycardia survived, compared with 15 out of 31 patients without them (P less than 0-005). During the latter part of the series when an arrhythmia computer was used to monitor 38 patients, it was shown that significantly lower arterial oxygen levels occurred in those with arrhythmias, other than sinus tachycardia, than in those without. They were also found to be more acidotic and hyperkalaemic, and a higher number required dialysis and ventilation. Macroscopical cardiac abnormalities including scattered petechial haemorrhages, small pericardial effusions, and fatty, pale, and flabby ventricles, were found at necropsy in 64 per cent of the patients examined. Combinations of these macroscopical abnormalities occurred, particularly in the paracetamol overdose group. Another necropsy finding of possible significance in the pathogenesis of arrhythmias was cerebral oedema, present in 48 per cent of the patients examined, and often associated with coning of the brain stem. However, 7 of the 16 patients who suffered asystolic cardiac arrests had no macroscopical abnormality of either heart or brain. In the management of patients with fulminant hepatic failure continuous cardiac monitoring is essential. Correction of the biochemical and coagulation defects may decrease the frequency of arrhythmias but studies of the mechanism and control of cerebral oedema and its relation to cardiovascular function are urgently needed.  (+info)

Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy. (6/1819)

BACKGROUND: Respiratory failure is the commonest cause of death in patients with Duchenne muscular dystrophy (DMD). Life expectancy is less than one year once diurnal hypercapnia develops. This study examines the effects of nasal intermittent positive pressure ventilation (NIPPV) on survival in symptomatic Duchenne patients with established ventilatory failure. METHODS: Nocturnal NIPPV was applied in 23 consecutive patients with DMD of mean (SD) age 20.3 (3.4) years who presented with diurnal and nocturnal hypercapnia. RESULTS: One year and five year survival rates were 85% (95% CI 69 to 100) and 73% (95% CI 53 to 94), respectively. Early changes in arterial blood gas tensions following NIPPV occurred with mean (SD) PO2 increasing from 7.6 (2.1) kPa to 10.8 (1.3) kPa and mean (SD) PCO2 falling from 10.3 (4.5) kPa to 6.1 (1.0) kPa. Improvements in arterial blood gas tensions were maintained over five years. Health perception and social aspects of SF-36 health related quality of life index were reported as equivalent to other groups with nonprogressive disorders using NIPPV. CONCLUSIONS: Nasal ventilation is likely to increase survival in hypercapnic patients with Duchenne muscular dystrophy and should be considered as a treatment option when ventilatory failure develops.  (+info)

Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat. (7/1819)

BACKGROUND: Inhalational anesthetics depress breathing dose dependently. The authors studied the dynamics of ventilation on changes in end-tidal sevoflurane partial pressure. To learn more about the mechanisms of sevoflurane-induced respiratory depression, the authors also studied its influence on the dynamic ventilatory response to carbon dioxide. METHODS: Experiments were performed in cats anesthetized with alpha chloralose-urethane. For protocol 1, step changes in end-tidal sevoflurane partial pressure were applied and inspired ventilation was measured. Breath-to-breath inspired ventilation was related to the sevoflurane concentration in a hypothetical effect compartment based on an inhibitory sigmoid Emax model. For protocol 2, step changes in the end-tidal partial pressure of carbon dioxide were applied at 0, 0.5, and 1% end-tidal sevoflurane. The inspired ventilation-end-tidal partial pressure of carbon dioxide data were analyzed using a two-compartment model of the respiratory controller, which consisted of a fast peripheral and slow central compartment. Values are the mean +/- SD. RESULTS: In protocol 1, the effect-site half-life of respiratory changes caused by alterations in end-tidal sevoflurane partial pressure was 3.6+/-1.0 min. In protocol 2, at 0.50% sevoflurane, the central and peripheral carbon dioxide sensitivities decreased to 43+/-20% and 36+/-18% of control. At 1% sevoflurane, the peripheral carbon dioxide sensitivity decreased further, to 12+/-13% of control, whereas the central carbon dioxide sensitivity showed no further decrease. CONCLUSIONS: Steady state inspired ventilation is reached after 18 min (i.e., 5 half-lives) on stepwise changes in end-tidal sevoflurane. Anesthetic concentrations of sevoflurane have, in addition to an effect on pathways common to the peripheral and central chemoreflex loops, a selective effect on the peripheral chemoreflex loop. Sevoflurane has similar effects on ventilatory control in humans and cats.  (+info)

Pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia. (8/1819)

We describe the case of a 53-year-old Philadelphia-chromosome-positive woman with chronic myelogenous leukemia, who developed pulmonary alveolar proteinosis (PAP). The possible mechanism involved in the pathogenesis of PAP are discussed based on the clinical and laboratory data for this patient as well as on experimental and clinical data reported in the literature.  (+info)

Acute hypoxemic respiratory failure may require invasive mechanical ventilation. However, invasive mechanical ventilation is associated with a variety of complications. Non-invasive ventilation has been presented as an alternative treatment but controversy remains. The investigators hypothesize that high-flow nasal cannula system is effective enough to prevent intubation in acute hypoxemic respiratory failure and not inferior to non-invasive ventilation ...
Non-invasive mechanical ventilation in acute respiratory failure due to chronic obstructive pulmonary disease: correlates for success. ...
TY - JOUR. T1 - Acute respiratory failure in children. AU - Friedman, Matthew L.. AU - Nitu, Mara. PY - 2018/7/1. Y1 - 2018/7/1. N2 - This article reviews the definition, pathophysiology, etiology, assessment, and management of acute respiratory failure in children. Acute respiratory failure is the inability of the respiratory system to maintain oxygenation or eliminate carbon dioxide. Acute respiratory failure is a common cause for admission to a pediatric intensive care unit. Most causes of acute respiratory failure can be grouped into one of three categories: lung parenchymal disease, airway obstruction, or neuromuscular dysfunction. Many patients with acute respiratory failure are managed successfully with noninvasive respiratory support; however, in severe cases, patients may require intubation and mechanical ventilation.. AB - This article reviews the definition, pathophysiology, etiology, assessment, and management of acute respiratory failure in children. Acute respiratory failure is the ...
TY - JOUR. T1 - Predictors of need of mechanical ventilation and reintubation in patients with acute respiratory failure secondary to chronic obstructive pulmonary disease. AU - Khilnani, G.. AU - Banga, Amit. AU - Sharma, S.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2006/4/1. Y1 - 2006/4/1. N2 - Background and Aims: To identify predictors of need of mechanical ventilation (MV) and that of reintubation, after a planned extubation, among the patients with exacerbation of chronic obstructive pulmonary disease. Materials and Methods: Prospectively collected data of 82 patients with exacerbation of COPD over a one-year period were reviewed. Clinical and demographic profile, APACHE II score, blood gas parameters and serum biochemistry, recorded at the time of admission, were compared between patients who required MV and those who did not. Parameters were also compared between the groups formed on the basis of requirement of reintubation. Results: Sixty-nine patients ...
Semantic Scholar extracted view of [Advantages of delayed-action intermittent corticotherapy in the treatment of asthma and chronic respiratory insufficiency]. by Paul Freour et al.
The successful treatment of hypercapnic respiratory failure with oral modafinil Helen Parnell,1 Ginny Quirke,1 Sally Farmer,1 Sumbo Adeyemo,2 Veronica Varney11Respiratory Department, 2Pharmacy Department, St Helier Hospital, Carshalton, Surrey, UKAbstract: Hypercapnic respiratory failure is common in advanced chronic obstructive pulmonary disease and is usually treated by nasal ventilation. Not all patients requiring such ventilation can tolerate it, with anxiety and phobia influencing their reaction, along with treatment failure. We report the case histories of six patients with hypercapnic respiratory failure who were at risk of death due to refusal of nasal ventilation or its failure despite ongoing treatment. We report their improvement with oral modafinil 200 mg tablets used as a respiratory stimulant, which led to discharge, improved arterial blood gases, and offset further admissions with hypercapnic respiratory failure. This drug is licensed for narcolepsy and is said to stimulate the
Davidson, AC, Banham, S, Elliott, M, Kennedy, D, Gelder, C, Glossop, A, Church, AC, Creagh-Brown, B, Dodd, JW, Felton, T et al, Foex, B, Mansfield, L, McDonnell, L, Parker, R, Patterson, CM, Sovani, M and Thomas, L. (2016) BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults ...
Doctors Ask: The syndrome of acute respiratory failure has different causes of occurrence. The emergence of symptoms of acute respiratory failure requires the provision of emergency care and further hospitalization. The syndrome of acute respiratory insufficiency is a pathological condition characterized by a sharp change in the process of gas exchange in the lungs.
The investigators in this study are concerned about the harmful effects of oxygen exposure in newborn infants, particularly at high concentrations. Inhaled nitric oxide (iNO) is an FDA approved drug for the treatment of hypoxic respiratory failure (HRF) in term and late-preterm babies greater than 34 weeks gestation. Hypoxic respiratory failure occurs when a patients lungs cannot get enough oxygen into their bloodstream. This condition is traditionally treated with high concentrations of oxygen and most often requires the patient be placed on a ventilator (breathing machine). The administration of inhaled nitric oxygen directly into the lungs often improves blood oxygen levels and allows caretakers to reduce the amount of oxygen given to the baby. The purpose of this research study is to evaluate if giving the inhaled nitric oxide earlier in the course of disease improves the effectiveness of the drug, reduces the amount of cellular injury from oxygen exposure, and decreases the total amount of ...
The Neonatal Research Network developed and initiated 3 multicenter randomized controlled clinical trials evaluating inhaled nitric oxide therapy. Additional projects evolved from these efforts including basic science research and observational investigations. This article provides a historical prospective of the Networks investigations related to the diagnosis and management of neonatal hypoxic respiratory failure, especially those related to inhaled nitric oxide therapy. It will review the Networks contributions toward advancing the clinical care of the newborn with severe hypoxic respiratory failure.
Background: Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas exchange compared with pulmonary rehabilitation alone in patients with COPD with chronic hypercapnic respiratory failure.. Methods: 72 patients with COPD were randomly assigned to nocturnal NIPPV in addition to rehabilitation (n = 37) or rehabilitation alone (n = 35). Outcome measures were assessed before and after the 3-month intervention period.. Results: The Chronic Respiratory Questionnaire total score improved 15.1 points with NIPPV + rehabilitation compared with 8.7 points with rehabilitation alone. The difference of 7.5 points was not significant (p = 0.08). However, compared with rehabilitation alone, ...
TY - JOUR. T1 - Management of hypercapnic respiratory failure. T2 - invasive versus non-invasive ventilatory support. AU - Westall, G.. AU - Naughton, M.. PY - 2001/12. Y1 - 2001/12. N2 - Introduction: Recently, non-invasive ventilatory support (NIVS), using a comfortable facial mask, has been used in cooperative patients, and been shown to reduce short and long-term mortality compared with invasive ventilatory support (IVS).2 Aims: We sought to respectively review the management of hypercapnic respiratory failure in patients presenting to the Alfred following the development of a NIVS protocol. Methods: Case records of all patients attending ED with dyspnoea and PaC02 45 mmHg between April and June 1999 were examined. Results: 169 cases were identified (age 60± 23 yrs, 56% female) of whom clinical evidence of COPD (52 %) and congestive heart failure (28%) were identified. As a group, in-hospital mortality was related to presenting PaC02 (9% with PaC02 45-50mmHg; 12% with PaC02 SI60 mmHg and 15 ...
TY - JOUR. T1 - Extracorporeal arteriovenous CO2 removal for severe respiratory failure. T2 - high versus low dose heparin. AU - Savage, Clare. AU - Alpard, Scott K.. AU - Murphy, Jennifer. AU - Deyo, Donald J.. AU - Jayroe, Jason B.. AU - Zwischenberger, Joseph B.. PY - 1999/12/1. Y1 - 1999/12/1. N2 - Objective: In prior studies, we established the safety and feasibility of percutaneous arteriovenous CO2 removal (AVCO2R) for severe respiratory failure using high dose heparin to minimize thrombosis with activated clotting times (ACT) , 300 sec (sheep) and , 260 sec (humans). We conducted a prospective randomized study of AVCO2R utilizing a new, commercially available, heparin-coated oxygenator comparing low dose heparin (, 200 sec) with high dose heparin (, 300 sec). Methods: Adult Suffolk ewes (n=10) received a combination cotton smoke inhalation (36 breaths) and cutaneous flame burn (40% TBSA III°) injury, with volume controlled mechanical ventilation. When animals met entry criteria for AEDS ...
Noninvasive positive pressure ventilation requires careful application in appropriate patients. It is most likely to benefit patients who are expected to improve rapidly, particularly those with acute exacerbations of chronic obstructive pulmonary disease. However, all forms of noninvasive ventilation, including CPAP, require scrupulous clinical monitoring so that endotracheal intubation and mechanical ventilation are instituted promptly before life-threatening respiratory failure becomes imminent and to avoid emergency intubation or cardiopulmonary arrest. Patients with acute lung injury who were chosen for the trial by Delclaux and colleagues might represent a group for whom many clinicians would avoid using CPAP because rapid improvement is not expected and previous evidence of effectiveness in this population is lacking. Patients with acute hypoxemic nonhyercapnic respiratory insufficiency may benefit from maintaining CPAP as continuously as possible, given the potential for rapid ...
A comprehensive and up-to-date exploration of all aspects of noninvasive mechanical ventilation Pays detailed attention to equipment, including new ventilation modes Written by internationally recognized experts The new edition presents updates regarding
A comprehensive and up-to-date exploration of all aspects of noninvasive mechanical ventilation Pays detailed attention to equipment, including full-face
Home mechanical ventilation (HMV) was initiated in polio centers in the mid-50s (iron lung). Ten years ago, chronic respiratory insufficiency patients began to be treated with positive pressure ventilation via tracheostomy tube. Survival of kyphoscoliotic and myopathic patients was impressive in uncontrolled studies. Today it appears that similar results may be obtained with a new non-invasive technique, nasal mechanical ventilation. The present situation of HMV in Switzerland (number of patients and their location) and the results of this treatment are described. In addition, we report on a short series of 24 Swiss patients collected in 4 centers. We show that HMV is possible in Switzerland and that the results in survival and quality of life are excellent, provided that the indications for this technique are consistent with the recommendations in the literature.
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Acute respiratory failure accounts for 25-40 % of ICU admissions and carries a mortality rate of 30 % or more. In this chapter, we classify acute respiratory failure in two main types, based on their...
Dr. Kearney presented an interesting case of an individual with untreated HIV who presented with dyspnea found to have hypoxemic respiratory failure. The patients history of a significant period of time off antiretroviral therapy (,3 years), the severity of the presentation of hypoxemic respiratory failure, and the severity of the lymphopenia (CD4# ,35) data-preserve-html-node=true raised suspicion for opportunistic infection. Sputum and blood cultures for fungus subsequently returned positive for Coccidioides immitis. Treatment had been started for coccidioidomycosis empirically with an azole and was subsequently increased to include amphotericin B once cultures returned positive. Highly active antiretroviral therapy was begun on admission as well. The patients respiratory failure improved over the subsequent days, but unfortunately he developed recurrent hypoxemic respiratory failure and pseudosepsis concerning for IRIS. The differential for dyspnea in the HIV+ patient is myriad. However, ...
Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock.
In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). HFNC has an effect on intubation but not on mortality rates.... Read More ...
Bry, C.; Jaffré, S.; Guyomarc'h, Béatrice.; Corne, Fédéric.; Chollet, S.; Magnan, A.; Blanc, Fçois-Xavier., 2017: Noninvasive Ventilation in Obese Subjects After Acute Respiratory Failure
50 mmHg; chronically, 20 mmHg above baseline), or both. The treatment is largely symptomatic and supportive, Dr. Pansiello says. There can be many causes of respiratory distress in children. When that happens, your lungs cant release oxygen … The higher incidence of respiratory failure in infants has several developmental explanations. Chronic respiratory failure - Respiratory failure happens gradually as a result of a long-standing disease or condition. Children having difficulty breathing often show signs that they are having to work hard to breathe or are not getting enough oxygen, indicating respiratory distress. High-flow outside ICU appears to be feasible in children with AHRF and the required proportion of escalation was lower compared to standard-oxygen. Learn more about Amazon Lockers. What defines acute respiratory failure is the failure to sustain the normal work of breathing, he says. National Heart, Lung, and Blood Institute. Some of those resources include: Immediate family ...
Acute respiratory failure in adults with severe thoracic scoliosis is said to be a preterminal event. The following analysis of 13 consecutive cases contradicts this assumption. All patients demonstrated a severe restrictive ventilatory defect (average vital capacity, 39% of predicted). In addition, five patients had evidence of airways obstruction, and six had abnormal steady-state diffusing capacities (average, 49% of predicted). Respiratory failure was precipitated by acute bronchopulmonary infection in seven cases, cor pulmonale in five, and barbiturates in one. Admission arterial blood gases were severely deranged: average arterial PCO2, 66 mm Hg; average pH, 7.31; average arterial oxygen saturation, 54%. ...
OBJECTIVE:: Inhibition of surfactant function and abnormal surfactant synthesis lead to surfactant dysfunction in children with acute hypoxemic respiratory failure. We evaluated whether intratracheal lucinactant, a synthetic, peptide-containing surfa
This systematic review shows a clear benefit of NPPV as an adjunct treatment to usual medical care in the management of patients admitted to hospital with respiratory failure secondary to an acute exacerbation of COPD. NPPV with usual medical care significantly reduces mortality, endotracheal intubation, treatment failure, complications, length of hospital stay, and blood gas tensions.. Although NPPV reduces the need for intubation, in some patients NPPV will fail, and it is essential that a decision be made with the patient on what should be done in this eventuality. Patients for whom NPPV eventually fails, despite initial tolerance and effectiveness of the treatment, need to be distinguished from patients who cannot tolerate it at all. An uncontrolled study of these late failures suggests a poor outcome regardless of whether the patient is intubated or continues to receive NPPV.21. NPPV reduced the length of stay in hospital by more than three days, and length of stay in hospital did not ...
ML Campbell, KS Bizek; Use of NIPPV in terminal respiratory insufficiency. Am J Crit Care 1 May 1994; 3 (3): 250-251. doi: https://doi.org/10.4037/ajcc1994.3.3.250-a. Download citation file:. ...
In this interactive case, Joline Dalton, MS, CGC, presents a case on a 32-year-old Male With Progressive Weakness, Dilated Cardiomyopathy and Respiratory Insufficiency
Respiratory Insufficiency information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
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Definition of respiratory failure in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is respiratory failure? Meaning of respiratory failure as a legal term. What does respiratory failure mean in law?
Acute respiratory failure (ARF) is responsible for about one-third of intensive care unit (ICU) admissions and is associated with adverse outcomes. Predictors of short- and long-term outcomes in unselected ICU-patients with ARF are ill-defined. The purpose of this analysis was to determine predictors of in-hospital and one-year mortality and assess the effects of oral beta-blockers in unselected ICU patients with ARF included in the BASEL-II-ICU study. The BASEL II-ICU study was a prospective, multicenter, randomized, single-blinded, controlled trial of 314 (mean age 70 (62 to 79) years) ICU patients with ARF evaluating impact of a B-type natriuretic peptide- (BNP) guided management strategy on short-term outcomes. In-hospital mortality was 16% (51 patients) and one-year mortality 41% (128 patients). Multivariate analysis assessed that oral beta-blockers at admission were associated with a lower risk of both in-hospital (HR 0.33 (0.14 to 0.74) P = 0.007) and one-year mortality (HR 0.29 (0.16 to 0.51) P
The hemodynamic responce to the pulmonary vascular changes caused by acute respiratory failure and the associated need for mechanical ventilation continues to puzzle the clinician and challenge the...
TY - JOUR. T1 - Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy. AU - Bauer, Philippe R.. AU - Chevret, Sylvie. AU - Yadav, Hemang. AU - Mehta, Sangeeta. AU - Pickkers, Peter. AU - Bukan, Ramin B.. AU - Rello, Jordi. AU - van de Louw, Andry. AU - Klouche, Kada. AU - Meert, Anne-Pascale. AU - Martin-Loeches, Ignacio. AU - Marsh, Brian. AU - Crespi, Lorenzo Socias. AU - Moreno-Gonzalez, Gabriel. AU - Buchtele, Nina. AU - Amrein, Karin. AU - Balik, Martin. AU - Antonelli, Massimo. AU - Nyunga, Martine. AU - Barratt-Due, Andreas. AU - Bergmans, Dennis C. J. J.. AU - Spoelstra-de Man, Angelique M. E.. AU - Kuitunen, Anne. AU - Wallet, Florent. AU - Seguin, Amelie. AU - Metaxa, Victoria. AU - Lemiale, Virginie. AU - Burghi, Gaston. AU - Demoule, Alexandre. AU - Karvunidis, Thomas. AU - Cotoia, Antonella. AU - Klepstad, Pal. AU - Moller, Ann M.. AU - Mokart, Djamel. AU - Azoulay, Elie. AU - Rabbat, Antoine. AU - Darmon, Michael. AU - Klouche, ...
Diagnosis: Right-Sided Pneumonia Leading to Acute Respiratory Failure Name Course Instructors Name Date Diagnosis: Right-Sided Pneumonia Leading to Acute Respi...
A quick reference on Acute respiratory failure, covering the clinical presentation, investigative approach, and key principles of management
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Care guide for Chronic Respiratory Failure. Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Noninvasive mechanical ventilation (NIV) is used to treat chronic ventilatory insufficiency (CVI) and acute respiratory failure (ARF). Various diseases cause CVI and here home mechanical ventilation (
6 • PH low or bicarbonate high . treatment for patients in type 1 respiratory failure, and despite initial concerns regarding its use in COVID-19, including the risk of lung barotrauma and increased SARS-CoV-2 aerosolisation, early anecdotal experience has been favourable with newer guidelines now suggesting CPAP as an option for care. Search results. However, other comorbid conditions, especially cardiovascular disease, are equally powerful predictors of mortality. There are various causes of respiratory failure, the most common being due to the lungs or heart. Type 2 failure is defined by a Pa o 2 of less than 60 mm Hg and a Pa co 2 of greater than 50 mm Hg. Type 1 failure is defined by a Pa o 2 of less than 60 mm Hg with a normal or low Pa co 2. ABG -Type 1 Resp Failure. You may also want to talk to a GP about the stop smoking treatments available. Type 3 (Peri-operative) Respiratory Failure: Type 3 respiratory failure can be considered as a subtype of type 1 failure. Respiratory diseases ...
Improvement in lung function measured by oxygenation levels and markers for disease severity and lung fibrosis. Treatment with sargramostim was safe, well tolerated and generated T-cells targeted at the SARS-CoV-2 virus, indicating a COVID-19 specific immune response Lexington, MA - February 26, 2021 /PRNewswire/ - Partner Therapeutics, Inc. (PTx) announced top-line results today of the investigator-led SARPAC (Sargramostim in Patients with Acute Hypoxic Respiratory Failure and Acute COVID-19) study of inhaled Leukine® (sargramostim, yeast-derived recombinant human GM-CSF) in hospitalized COVID-19 patients (NCT04326920).1,2 This prospective, randomized, open-label study was led by University Hospital Ghent and conducted at five hospitals in Belgium. The study enrolled 81 patients with PCR-confirmed COVID-19 who were suffering from acute hypoxic respiratory failure requiring supplemental oxygen. The full study and translational results are being prepared for publication.. Lung dysfunction ...
Nitric oxide is probably unique in terms of the course of events leading to its designation as a drug. After the identification of endothelium-derived relaxing factor as nitric oxide, there was much excitement about the therapeutic potential of this simple molecule across a whole range of medical specialties. Cost was certainly not an issue. However, after little more than 10 years, much of the therapeutic promise has not (yet) occurred, but cost certainly is now an issue.. The article by Angus et al1 in this issue looks specifically at the cost effectiveness of a policy of using nitric oxide in mature infants with severe respiratory … Address correspondence to David Field, DM, FRCPCH, Neonatal Unit, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, United Kingdom. E-mail: david.field{at}uhl-tr.nhs.uk. ...
Background: Invasive mechanical ventilation (IMV) is frequently used in patients with community-acquired pneumonia (CAP) and severe respiratory failure. However, there is little information on these patients.. Methods: We prospectively enrolled consecutive patients hospitalized with CAP for 12 yrs. We assessed the characteristics and outcomes of patients on IMV, those who needed non-invasive ventilation (NIV) and no ventilatory support, and determined predictors for the need of ventilation and mortality.. Results: Among 3,719 patients included, 154 (4%) required IMV, 136 (4%) NIV, and 3,429 (92%) were not ventilated. Streptococcus pneumoniae was the main pathogen. Current alcohol consumption, higher levels of C-reactive protein, worse baseline oxygenation, higher Pneumonia Severity Index, and bacteremia at admission independently predicted the need for IMV, while former tobacco consumption and fever at admission were independently associated with no need for IMV. Likewise, higher levels of ...
Subjects are excluded from the study if any of the criteria below apply. COVID-19 Related Medical Conditions 1. Respiratory failure at the time of screening (see Section 3 for definition of respiratory failure) due to COVID-19 pneumonia. 2. Known medical resuscitation within 14 days of randomization. 3. Any serious medical condition or abnormality of clinical laboratory tests that, in the Investigator s judgment, precludes the subject s safe participation in and completion of the study. 4. Suspected uncontrolled active bacterial, fungal, viral, or other infection (besides infection with SARSCoV2). 5. In the opinion of the Investigator, progression to death is imminent and inevitable within the next 24 hours, irrespective of the provision of treatments. Medical Conditions 6. Not expected to survive 28 days given their preexisting, uncorrectable medical condition, for example, subjects with, or suspected to have, the following conditions: multiorgan failure, poorly controlled neoplasms; endstage ...
TY - JOUR. T1 - New clinically relevant sheep model of severe respiratory failure secondary to combined smoke inhalation/cutaneous flame injury. AU - Alpard, Scott K.. AU - Zwischenberger, Joseph B.. AU - Tao, Weike. AU - Deyo, Donald J.. AU - Traber, Daniel L.. AU - Bidani, Akhil. PY - 2000. Y1 - 2000. N2 - Objectives: To develop a predictable, dose-dependent, clinically relevant model of severe respiratory failure associated with a 40% total body surface area, full-thickness (third-degree) cutaneous flame burn and smoke inhalation injury in adult sheep. Design: Model development. Setting: Research laboratory. Subjects: Adult female sheep (n = 22). Interventions: Animals were divided into three groups, determined by the number of smoke breaths administered (24, 36, 48) for a graded inhalation injury. The smoke was insufflated into a tracheostomy with a modified bee smoker at airway temperatures ,40°C. All animals concurrently received a 40% total body surface area (third-degree) cutaneous ...
Prior studies have shown that nasal intermittent positive pressure ventilation (NIPPV) can improve arterial blood gas values, prevent symptoms resulting from alveolar hypoventilation, and decrease hospitalization in patients with chronic respiratory failure. Most studies have involved small samples …
TY - JOUR. T1 - Thyrotoxic periodic paralysis complicated by acute hypercapnic respiratory failure and ventricular tachycardia. AU - Wu, Chung Ze. AU - Wu, Yao Kuang. AU - Lin, Jiunn Diann. AU - Kuo, Shi Wen. PY - 2008/12/1. Y1 - 2008/12/1. N2 - Background: Thyrotoxic hypokalemic periodic paralysis in combination with an acute episode of general flaccid paralysis and hypokalemia is common in young Asian men with hyperthyroidism. We report the very rare complications of involvement of the respiratory muscles and ventricular tachycardia in this disorder. Summary: A 29-year-old man exhibited profound paralysis after prolonged fasting. Severe hypokalemia was noted (K +: 1.4 mmol/L). Although the patient was treated with potassium chloride, he suffered from respiratory distress and chest tightness. Arterial blood gas indicated acute hypercapnic respiratory failure (pCO 2: 118.9 mmHg), and ventricular tachycardia was documented by electrocardiogram. The patient was intubated for ventilatory support ...
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia ...
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Our patients, who were managed with v-v ECMO for severe respiratory failure, had ICU mortality and hospital mortality of 19.4% and 22.6%, respectively. Most of them (n=29; 93.6%) had severe ARDS that failed conventional treatment. Our results (7 dead/24 alive) compared favourably with the ECLS (Extracorporeal Life Support) Registry Report,8 in which the hospital mortality was reported to be 44% (2283 dead/2905 alive; P=0.018 by Fishers exact test). Mortality of ARDS, before 1990s, was higher than 50%.9 10 Mechanical ventilator is the cornerstone of treatment for ARDS. Although it can support lung ventilation, inappropriate use can lead to lung damage including excessive transpulmonary pressure (barotrauma), excessive lung volume inside alveoli (volutrauma), and shearing stress during repetitive opening and closing of alveoli (atelectrauma).11 Moreover, the damage caused by mechanical ventilation is not limited to the lungs. Lung trauma can trigger systemic inflammatory response (biotrauma) that ...
TY - JOUR. T1 - Extracorporeal membrane oxygenation for the treatment of neonatal respiratory failure. AU - Carey, William A.. AU - Colby, Christopher E.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2009/9. Y1 - 2009/9. N2 - This review discusses the use of extracorporeal membrane oxygenation (ECMO) for the treatment of respiratory failure in neonates. After briefly reviewing the early history of neonatal ECMO, the authors describe the respiratory diagnoses most often treated with ECMO and the manner in which affected neonates are deemed to have failed conventional therapies and thus require ECMO. After reviewing the most common indications for ECMO, factors that influence the timing of conversion to extracorporeal life support, as well as criteria that may exclude patients from receiving ECMO therapy, are described. At the conclusion of this article, the authors discuss the long-term outcomes of neonates whose respiratory disease was treated with ECMO and the ...
The mechanism cannot be inferred from this review. Studies have indicated that lung protective ventilation during NIPPV was as important as it was during invasive mechanical ventilation in respiratory failure [3]. However, strategies such as using low tidal volumes are unlikely to work under NIPPV treatment [4] and, compared to HFNC, NIPPV was associated with higher tidal volumes, which was strongly associated with ventilator-induced lung injury.. Thus, we speculated that, in patients with low baseline PaO2/FiO2 (which to some extent indicate more severe lung injury), high tidal volume-related ventilation-induced lung injury (VILI) was more likely to happen under NIPPV therapy. Yet, both NIPPV and HFNC were still suitable for patients with mild lung injury (high PaO2/FiO2 level). This finding suggests an interactive role of PaO2/FiO2 with NIPPV and the importance of proper patient selection before NIPPV treatment. Further studies are needed to explore which acute respiratory failure patients are ...
When low-TV ventilation was compared to higher TV, the former resulted in lower mortality and better secondary outcomes. The strategy used in this study included setting TV to 6 ml/kg PBW, limiting Pplat to less than 30 cmH2O and using a nomogram to set PEEP and FiO2. This is currently considered the standard ventilatory management for ARDS. Although Pplat limitation to less than 30 cmH2O and TV limitation to 6 ml/kg IBW is recommended, there is no evidence that this constitutes a safety limit.. Radiological evidence suggests overdistension and inflammatory activation at Pplat values between 25 and 30. Of note, if the plateau pressure is less than 30 cmH2O while receiving a high TV above 6 ml/kg IBW, the TV should still be reduced to approximately 6 ml/kg, as evidence suggests that the mortality benefit associated with low tidal volumes is independent of the compliance and Pplat.. The use of higher levels of PEEP (with or without recruitment maneuvers) to enhance alveolar opening and minimize ...
Delayed but successful response to noninvasive ventilation in COPD patients with acute hypercapnic respiratory failure Malcolm Lemyze,1,2 Quentin Bury,3 Aurélie Guiot,4 Marie Jonard,1,2 Usman Mohammad,2 Nicolas Van Grunderbeeck,5 Gaelle Gasan,1 Didier Thevenin,2 Jihad Mallat2 1Department of Respiratory and Critical Care Medicine, Schaffner Hospital, Lens, 2Intensive Care Unit, Arras Hospital, Arras, 3Respiratory Intermediate Care Unit, Béthune Beuvry Hospital, Béthune, 4Department of Cardiology, Bois Bernard Hospital, Bois Bernard, 5Respiratory Step Down Unit, Schaffner Hospital, Lens, France Background: We evaluated a new noninvasive ventilation (NIV) protocol that allows the pursuit of NIV in the case of persistent severe respiratory acidosis despite a first NIV challenge in COPD patients with acute hypercapnic respiratory failure (AHRF). Patients and methods: A prospective observational multicentric pilot study was conducted in three tertiary hospitals over a 12-month study
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...
Hereditary Proximal Myopathy with Early Respiratory Failure (HMERF): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
4: Bourke SC, et al. Noninvasive ventilation in ALS: Indications and effect on quality of life. Neurology 2003; 61:171-177. 5: Eagle M, Bourke J, Bullock R, et al. Managing Duchenne muscular dystrophy-the additive effect of spinal surgery and home nocturnal ventilation in improving survival. Neuromuscular Disorders 2007; 17:470-5. 6: Leger P, Bedicam JM, Cornette A et al. Nasal intermittent positive pressure ventilation. Long term follow up in patients with severe chronic respiratory insufficiency. Chest 1994; 105:100-105. ...
He became ill with a clinical viral upper respiratory tract infection, which evolved into bilateral pneumonia. He was transferred from the Emergency Department to the Intensive Care Unit (ICU), where he was intubated and mechanically ventilated. At three weeks he was not making significant progress and was transferred to the Pediatric Intensive Care Unit (PICU) at the British Columbias Childrens Hospital. After two additional weeks of ventilation and intensive physiotherapy, his secretions settled, his atelectasis resolved, and he was successfully extubated to noninvasive ventilation (NIPPV). Several days later the PICU physiotherapists reported that he was losing strength in his right arm. A Computed Tomography (CT) scan revealed hydrocephalus, and on reviewing his chest X-rays, including xrays from the referring hospital, several showed that that his shunt had become disconnected high in his neck. The shunt was revised, but polysomnography continued to show hypopnea and central apnea. He was ...
In the acute setting non-invasive positive pressure ventilation (NPPV) is aimed at avoiding intubation and intubation-related complications. In some conditions such as acute exacerbation of chronic obstructive pulmonary disease the avoidance of intubation gained by NPPV has been shown to substantially improve intensive care unit (ICU) survival. However, NPPV is typically performed in conscious patients and might eventually fail as a reason of intolerance or inefficiency. In this scenario intubation occurs possibly too late, which negatively impacts on prognosis. Therefore, the issue of NPPV failure is acknowledged to be of major importance. In general, two global reasons can be responsible for NPPV failure, firstly, predefined conditions independent from staff handling, and secondly, common treatment mistakes. Predefined conditions are unchangeable and primarily refer to specific underlying conditions (e.g. hypoxemic versus hypercapnic respiratory failure), disease severity, and complications ...
Endotracheal intubation and mechanical ventilation are lifesaving interventions that are commonly performed in the intensive care unit (ICU). The trauma of endotracheal intubation itself, the prolongued pressure exerted by the endotracheal tube on the larynx, and miscellaneous factors such as fluid overload can result in laryngeal edema (LE). Extubation of a patient with undiagnosed LE can results in respiratory failure secondary to an upper airway obstruction and may require reintubation. Respiratory failure requiring reintubation is associated with morbidity and mortality. The cuff leak test (CLT) is the only method intensivists use to predict the presence of LE. Despite the CLTs first description in 1988, the correct way to interpret the results (either qualitatively or quantitatively) is unknown, and its diagnostic accuracy has been called into question. In fact, the CLT could be detrimental to patients if it has a high false positive rate (i.e. no air leak is detected indicating LE when ...
Endotracheal intubation and mechanical ventilation are lifesaving interventions that are commonly performed in the intensive care unit (ICU). The trauma of endotracheal intubation itself, the prolongued pressure exerted by the endotracheal tube on the larynx, and miscellaneous factors such as fluid overload can result in laryngeal edema (LE). Extubation of a patient with undiagnosed LE can results in respiratory failure secondary to an upper airway obstruction and may require reintubation. Respiratory failure requiring reintubation is associated with morbidity and mortality. The cuff leak test (CLT) is the only method intensivists use to predict the presence of LE. Despite the CLTs first description in 1988, the correct way to interpret the results (either qualitatively or quantitatively) is unknown, and its diagnostic accuracy has been called into question. In fact, the CLT could be detrimental to patients if it has a high false positive rate (i.e. no air leak is detected indicating LE when ...
Dive into the research topics of Extracorporeal venovenous membrane oxygenation in the treatment of respiratory insufficiency following cardiac surgery. Together they form a unique fingerprint. ...
In recent years, high flow nasal cannula is being increasingly used. Most studies showed positive results when used in hypoxaemic respiratory failure. Its use in a patient with a large endobronchial mass has not yet being described. We report a patient who presented with hemoptysis and hypoxaemic respiratory failure second to a large mass obstructing the right main bronchus. High flow oxygen via nasal cannula was initiated with a quick improvement of the hemoptysis and the oxygen saturation. Thus, allowing the patient to be rapidly stabilized.. ...
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(Health-NewsWire.Net, March 24, 2020 ) Market Overview The Global Acute Lung Injury Market is expected to grow at a CAGR of 5.8% during the forecasting period (2019-2026). Acute lung injury is a severe condition caused by acute hypoxemic respiratory failure. It is a crucial source of mortality a
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Post-Polio Health International, of which International Ventilator Users Network is an affiliate, announced that it has awarded a $25,000 research grant to a team from Johns Hopkins University. The researchers propose to determine whether early use of noninvasive positive pressure ventilation (NIPPV) prolongs survival in patients with amyotrophic lateral sclerosis (ALS) and to relate their findings to other neuromuscular diseases including polio and its late effects.. ALS, also known as Lou Gehrigs disease, is a progressive neurodegenerative disease that attacks nerve cells in the brain and spinal cord resulting in muscle weakness, atrophy and, eventually, death. The respiratory muscles are invariably affected, and respiratory failure is the most common cause of death in ALS patients.. NIPPV is becoming an increasingly standard treatment for patients with chronic respiratory failure, and observational studies suggest that NIPPV prolongs survival, but it is not known whether it modifies disease ...
ABSTRACT Background: Sepsis due to respiratory disease is one of the main complications of HIV/AIDS. Audit data from the Department of Internal Medicine at the University Teaching Hospital in Lusaka, Zambia indicate that pneumonia and tuberculosis in HIV represent two of the four leading causes of death. The mortality rate has remained high despite the advances made in antimicrobial spectrum.
A ventilation device for non-invasive positive pressure ventilation (NIPPV) or continuous positive airway pressure (CPAP) treatment of a patient has a gas flow generator, a gas delivery circuit optionally including a humidifier, a controller and sensors monitoring values of operational parameters of the device. The device further includes one or more relationships stored in data storage of the controller relating combinations of parameter values as being indicative of fault conditions of the device operation, the sensors and/or the fault detection process.
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with acute hypercapnic respiratory failure (AHRF) is associated with high mortality and increased risk for further exacerbations and hospitalization. While there is ample evidence regarding the benefit of noninvasive ventilation (NIV) during AECOPD, evidence supporting long-term noninvasive ventilation (LTNIV) for more stable COPD patients is limited. Objective: The aim of this study is to assess the effectiveness of LTNIV in COPD patients requiring frequent hospital admissions and NIV support for AHRF. Materials and Methods: A prospective cohort study including 120 patients having survived an admission requiring NIV support for AHRF due to COPD, with a history of ≥3 similar episodes in the past year. Patients were advised LTNIV (30) with standard treatment, or (90) standard treatment alone. Both groups were followed up for 1 year. Among non-NIV group 10 died, and 8 lost follow-up, whereas two died in NIV group. ...
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with acute hypercapnic respiratory failure (AHRF) is associated with high mortality and increased risk for further exacerbations and hospitalization. While there is ample evidence regarding the benefit of noninvasive ventilation (NIV) during AECOPD, evidence supporting long-term noninvasive ventilation (LTNIV) for more stable COPD patients is limited. Objective: The aim of this study is to assess the effectiveness of LTNIV in COPD patients requiring frequent hospital admissions and NIV support for AHRF. Materials and Methods: A prospective cohort study including 120 patients having survived an admission requiring NIV support for AHRF due to COPD, with a history of ≥3 similar episodes in the past year. Patients were advised LTNIV (30) with standard treatment, or (90) standard treatment alone. Both groups were followed up for 1 year. Among non-NIV group 10 died, and 8 lost follow-up, whereas two died in NIV group. ...
NPPV may be an alternative to conventional ventilation in selected patients with ARF after abdominal surgery who require ventilatory support.
This unique, single-source volume--the only comprehensive, first-line reference available on the subject-provides in-depth, up-to-date reviews of both the clinical and pathophysiological aspects of acute respiratory failure (ARF) in chronic obstructive pulmonary disease (COPD).
Question 2.. A 62 year old man with known chronic renal failure presents with respiratory failure secondary to pulmonary oedema. Oxygen saturation is 89% on 100% oxygen utilizing bi-level positive airway pressure (BiPAP). His observations are:. ...
Welcome to the September REBELCast 2014, where Matt, Swami, and I are going to tackle a couple more scenarios to help your clinical practice. Today, we are going to specifically tackle two different topics: Topic #1: The use of Non-Invasive Positive Pressure Ventilation (NIPPV) in the Pre-Hospital Treatment of Patients with Severe Respiratory Distress Topic #2: Once Weekly Dalbavancin for Skin Infections...Read More ...
Restrictive lung disease refers to a group of thoracic deformities that result in inefficient coupling between the respiratory muscles and the thoracic cage. The disorders are usually characterised by a restrictive defect and share the potential to cause long term hypercapnic respiratory failure.1. The most common thoracic abnormality leading to respiratory failure is thoracoplasty. Scoliosis and/or kyphoscoliosis may also cause severe respiratory failure ...
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Evidence-based recommendations on intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure in people with motor neurone disease
Evidence-based recommendations on intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure in people with motor neurone disease
|i|Background:|/i| It is likely that the imbalance between the pro- and anti-inflammatory cytokines will determine the outcome in infants with severe respiratory failure receiving extracor
p,,b,RATIONALE: ,/b,Low-tidal volume ventilation (LTVV; 6 ml/kg) benefits patients with acute respiratory distress syndrome and may aid those with other causes of respiratory failure. Current early ventilation practices are poorly defined.,/p,,p,,b,OBJECTIVES: ,/b,We observed patients with acute respiratory failure to assess the feasibility of a pragmatic trial of LTVV and to guide experimental design.,/p,,p,,b,METHODS: ,/b,We prospectively enrolled consecutive patients with acute respiratory failure admitted to intensive care units expected to participate in the proposed trial. We collected clinical data as well as information on initial and daily ventilator settings and inpatient mortality. We estimated the benefit of LTVV using predictive linear and nonlinear models. We simulated models to estimate power and feasibility of a cluster-randomized trial of LTVV versus usual care in acute respiratory failure.,/p,,p,,b,RESULTS: ,/b,We included 2,484 newly mechanically ventilated patients (31% with ...
Patients receiving parenteral and neuraxial opioids are at risk of depressed respiration. Traditional practice in medical-surgical units and other general care areas has been to intermittently monitor these patients, typically at four-hour intervals, using vital signs monitors. These monitors can be used to spot-check pulse rate, blood pressure, temperature, and oxygen saturation; and while the monitor is operating, the clinician counts respirations for a fraction of a minute to determine respiration rate.. Respiratory depression, however, can quickly lead to anoxic brain injury or death if not detected. Thus, assessing the condition of these patients at such long intervals will not reliably detect hypoventilation associated with this condition. As a result, several organizations now recommend that these patients be continuously monitored for respiratory depression.. This recommendation presents some significant challenges for health care providers. ECRI Institute has identified and answered ...
Respiratory insufficiency. 16%. 19%. 0.8. 57,054. 2001-10 Congestive heart failure. 19%. 19%. 1.0. 40,362. 2001-10 ... Compression-only CPR is not as good for children who are more likely to have cardiac arrest from respiratory causes. Two ... Tests, surgery and other procedures involving the respiratory system (ICD-9-CM V3 21-22, 30-34, ICD-10-PCS 0B) ... respiratory arrest) artificial ventilations may be more appropriate, but, due to the difficulty people have in accurately ...
December 20 - Jesús Castillo Rangel (121), Revolutionary and farmer, Mexico's oldest man; respiratory insufficiency and ... March 13 - Sarah Jiménez, engraving artist, member of the Salón de la Plástica Mexicana; respiratory problems (b. 1927). March ... Baltazar Maldonado Rosales (55), polítician (former mayor of Apizaco Municipality, Tlaxcala; renal insufficiency and cáncer (b ... respiratory complications (b. March 30, 1921). September 5 - José Durán González, 67, polítician, former mayor of Pueblo Nuevo ...
Dysphagia may occur, as can respiratory insufficiency.[citation needed] The etiology is unknown. Some cases of SLONM have been ... Generally the outcome is grim, with respiratory insufficiency the cause of death.[citation needed] Rehabilitation for muscle ...
Respiratory insufficiency may require treatment with supplemental oxygen. Aggressive management of airway secretions is ...
Molinaro died of a respiratory insufficiency in 2013. He was 85. Les Alchimistes (1957, short) Le Dos au mur [fr] (Back to the ...
Respiratory insufficiency develops in a small proportion of cases. Creatine kinase tend to be normal and electromyography (EMG ...
"Respiratory insufficiency as a presenting symptom of LGMD2D in adulthood". Acta Myologica. 23 (1): 1-5. PMID 15298081. White SJ ...
Wayne Tippit, 76, American character actor (Melrose Place), respiratory insufficiency. Henk van Ulsen, 82, Dutch actor. Gennaro ... Sir Harry Fang, 86, Hong Kong orthopaedic surgeon, President of Rehabilitation International (1980-1984), respiratory failure. ...
Survival is typically determined by the level of respiratory muscle insufficiency. Jungbluth, Heinz (2007). "Central core ... In its severest form, affected babies often die from respiratory failure. To date, 9 gene mutations have been found to cause ...
On 5 May 2009, Capetillo died of respiratory insufficiency, in Chacala, Nayarit. The wake was held in Guadalajara, Jalisco, and ... the actor's son confirmed that a respiratory insufficiency was the cause of his death. El revólver sangriento (1964) Alma ...
Life expectancy is generally not affected, except in rare cases of respiratory insufficiency. The first description of an ... PFT should also be done recurrently for those with risks for or symptoms of pulmonary insufficiency. Aerobic exercise has been ...
Lesions in the brainstem or upper cervical spinal cord can cause respiratory insufficiency. Lesions in area postrema of the ... In some patients (33% in one study), transverse myelitis in the cervical spinal cord resulted in respiratory failure and ...
... it may cause obstruction of the airway with resulting life-threatening respiratory insufficiency. Other injuries accompany TBI ... Dyspnea and respiratory distress are found in 76-100% of people with TBI, and coughing up blood has been found in up to 25%. ... Granholm T, Farmer DL (2001). "The surgical airway". Respiratory Care Clinics of North America. 7 (1): 13-23. doi:10.1016/S1078 ... People with a narrowed airway may suffer dyspnea, coughing, wheezing, respiratory tract infection, and difficulty with clearing ...
On April 20, 2010 Ricardo Valencia died after suffering respiratory insufficiency, brought on by a pulmonary fibrosis. He is ...
Patarinski, D (1976). "Indications and contraindications for oxygen therapy of respiratory insufficiency". Vŭtreshni bolesti ( ... "American Journal of Respiratory and Critical Care Medicine. 174 (4): 373-78. doi:10.1164/rccm.200507-1161WS. PMC 2648117. PMID ... MacNee, W. (2005). "Prescription of Oxygen". American Journal of Respiratory and Critical Care Medicine. 172 (5): 517-18. doi: ... "Respiratory Care. 55 (4): 408-13. PMID 20406507. Archived from the original on 2013-05-11.. ...
He died on 19 April 2016, aged 97 from natural causes from respiratory insufficiency. His state funeral was held on 22 April ...
Philippe Lacoue-Labarthe, 66, French professor of aesthetics at University of Strasbourg, respiratory insufficiency. Herbert ... Alice Coltrane, 69, American jazz musician and widow of John Coltrane, respiratory failure. Stephen Gilbert, 96, British ... Alfredo Ripstein, 90, Mexican movie producer, respiratory failure. Vern Ruhle, 55, American Major League Baseball pitcher and ...
... causing right-heart insufficiency, and bronchiectasis, manifesting in productive cough and respiratory failure. A 20-year ... In the last year of his life, he endured diarrheas, caused either by cor pulmonale or by exocrine pancreatic insufficiency (see ... His death would be explained by liver failure and respiratory failure due to chronic obstructive pulmonary disease.[citation ... Frédéric's symptoms of liver insufficiency would be hypoproteinemia, feminization features (no facial hair) and ...
Infants born with a Bochdalek hernia have a "high mortality rate due to respiratory insufficiency". Between 25-60% of infants ... Bochdalek hernias are life-threatening conditions due to respiratory distress. Like the lungs, the intestines may also have ...
1964;34:1401-3. Polish) EXCRETION OF UROPEPSIN AND 17-KETOSTEROIDS IN PATIENTS WITH RESPIRATORY INSUFFICIENCY (Pol Arch Med ... Polish) Attempted clarification of pathogenesis and hazards of peptic ulcer in circulatory insufficiency (Pol Tyg Lek (Wars). ...
... died at the age of 89 of respiratory insufficiency in his apartment in Copacabana. His grave is in the Cemitério ...
Albert Raisner (1922 - 2011), French harmonica player, died aged 88 of respiratory insufficiency at the Hospital ; Eddie ...
However, many individuals with Jarcho-Levin suffer from problems of respiratory insufficiency secondary to volume-restricted ... Infants born with this condition typically died early in life due to recurrent respiratory infections and pneumonia due to ...
On 14 January 2015 Kemal was hospitalized at Istanbul University's Çapa Medical Faculty, due to respiratory insufficiency. ...
On 14 July 1997, Welby suffered a respiratory insufficiency that left him completely unable to breathe naturally. He depended ...
The resulting respiratory insufficiency caused overload of the heart's right chambers, a chronic condition called cor pulmonale ... despite the extreme risk of inducing respiratory depression, apnea, and death in a patient with decreased respiratory reserve. ...
Late cases that might never be highlighted are respiratory insufficiency, cardiac insufficiency (cor pulmonale), cancer and ... The initial effects of exposure were coughing, severe eye irritation and a feeling of suffocation, burning in the respiratory ... Doctors at the Sambhavna Clinic treated him with oxygen, painkillers and anti-inflammatories following a severe respiratory ... respiratory issues, birth defects, and elevated rates of cancer and tuberculosis." The Government of India had focused ...
Patarinski, D (1976). "Indications and contraindications for oxygen therapy of respiratory insufficiency". Vŭtreshni Bolesti ( ... Oxygen should never be given to a person who has paraquat poisoning unless they have severe respiratory distress or respiratory ... Roca O, Riera J, Torres F, Masclans JR (April 2010). "High-flow oxygen therapy in acute respiratory failure". Respiratory Care ... However, the risk of the loss of respiratory drive are far outweighed by the risks of withholding emergency oxygen, and ...
... occur suddenly from acute pulmonary haemorrhage or after progressive pulmonary insufficiency resulting in chronic respiratory ... Heiner, DC (1990). "Pulmonary hemosiderosis". In Chernick V, Kendig EL Jr (eds.). Disorders of the respiratory tract in ... Boat, TF (1998). "Idiopathic pulmonary hemosiderosis". In Chernick V, Boat T (eds.). Kendig's disorders of the respiratory ... Pulmonary fibrosis Adult respiratory distress syndrome (ARDS) Immune complex disease intra-alveolar bleeding Clinically, IPH ...
It proved to be lifesaving in other conditions including respiratory insufficiency and soon superseded the iron lung throughout ... Bjork, V. O.; Engstrom, C. G. (1955). "The treatment of ventilatory insufficiency after pulmonary resection with tracheostomy ... "Treatment of Severe Cases of Respiratory Paralysis by the Engstrom Universal Respirator". BMJ. 2 (4889): 666-669. doi:10.1136/ ... "The physiological challenges of the 1952 Copenhagen poliomyelitis epidemic and a renaissance in clinical respiratory physiology ...
Inflammatory reaction (e.g. acute respiratory tract infections, chronic sinusitis, rhinitis or environmental irritants) ...
Respiratory. *Intrauterine hypoxia. *Infant respiratory distress syndrome. *Transient tachypnea of the newborn ...
respiratory minute volume. FEV1/FVC ratio. Lung function tests. spirometry. body plethysmography. peak flow meter. nitrogen ...
Clinical Medicine: Circulatory, Respiratory, and Pulmonary Medicine. 2: 35-44. PMC 2990232. PMID 21157520. Retrieved 14 ... Adrenal insufficiency. *Cushing's syndrome. References[edit]. *^ a b Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 10: ...
"The American Review of Respiratory Disease. 118 (3): 635-6. doi:10.1128/mcb.10.8.3859. PMC 360896. PMID 2196437.. ... Some diseases that can be caused due to this insufficiency by specific gene transcription are: Thalassemia,[32] lung cancer,[33 ...
American Journal of Respiratory and Critical Care Medicine. 2016-12-01. ISSN 1535-4970. PMID 27907454. doi:10.1164/rccm.201605- ... Premature ovarian insufficiency: the context of long-term effects.. Journal of endocrinological investigation. September 2016, ... European Respiratory Journal. 2016-11-01, 48 (5): 1288-97 [2017-08-04]. ISSN 0903-1936. PMID 27660514. doi:10.1183/ ...
to detect respiratory disease in patients presenting with symptoms of breathlessness, and to distinguish respiratory from ... In those with acute respiratory failure on mechanical ventilation, "the static compliance of the total respiratory system is ... May 1985). "Measurement of static compliance of the total respiratory system in patients with acute respiratory failure during ... respiratory minute volume. FEV1/FVC ratio. Lung function tests. spirometry. body plethysmography. peak flow meter. nitrogen ...
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... Critical illness-related corticosteroid insufficiency. *Decubitus ulcers. *Fungemia. *Stress hyperglycemia. *Stress ulcer ...
The surgical treatment for velopalatal insufficiency may cause obstructive sleep apnea syndrome. When velopalatal insufficiency ... "American Journal of Respiratory and Critical Care Medicine. 191 (11): 1295-1309. doi:10.1164/rccm.201501-0169OC. PMC 4476519. ... This can be the result of an upper respiratory infection that causes nasal congestion, along with swelling of the throat, or ... Obese adults show an increase in pharyngeal tissue which cause respiratory obstruction during sleep.[6] Adults with normal body ...
Diseases and disorders of the lungs or the vocal cords, including paralysis, respiratory infections (bronchitis), vocal fold ...
Additional laboratory changes (metabolic and respiratory acidosis, disseminated intravascular coagulation). More recently, ...
... and respiratory insufficiency.[120] In 2006, it was discovered that the protein TDP-43 is a major component of the inclusion ... Respiratory onset[edit]. Respiratory-onset ALS is a rare variant that accounts for about 3% of all cases of ALS,[11] in which ... In respiratory-onset ALS, this may occur before significant limb weakness is apparent. Most people with ALS die of respiratory ... This involves asking the person with ALS if they have any respiratory symptoms and measuring their respiratory function.[5] The ...
... are underdeveloped at the time of birth the infant will not be able to breathe air properly and will go into respiratory ... or uteroplacental insufficiency from maternal hypertension. ...
The pharynx is a part of the conducting zone of the respiratory system and also a part of the digestive system. It is the part ... Malabsorption can have many causes ranging from infection, to enzyme deficiencies such as exocrine pancreatic insufficiency. It ...
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... Critical illness-related corticosteroid insufficiency. *Decubitus ulcers. *Fungemia. *Stress hyperglycemia. *Stress ulcer ...
Respiratory. *Intrauterine hypoxia. *Infant respiratory distress syndrome. *Transient tachypnea of the newborn ...
Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. Its ...
Respiratory compensation a mechanism of the respiratory center, adjusts the partial pressure of carbon dioxide by changing the ... and also why persons with pulmonary insufficiency or right-to-left shunts in the heart (through which venous blood by-passes ... Changes in the levels of oxygen, carbon dioxide, and plasma pH are sent to the respiratory center, in the brainstem where they ... Control centres include the respiratory centre, and the renin-angiotensin system. An effector is the target acted on, to bring ...
American Journal of Respiratory and Critical Care Medicine. January 15, 2012, 185 (2): 133-9 [2015-02-08]. PMID 21680949. doi: ... 重症相關糖皮質激素不足(英语:Critical illness-related corticosteroid insufficiency) ... insufficiency)、低血容量、心臟衰
respiratory minute volume. FEV1/FVC ratio. Lung function tests. spirometry. body plethysmography. peak flow meter. nitrogen ... Epstein, F. H.; Hsia, C. C. W. (1998). "Respiratory Function of Hemoglobin". New England Journal of Medicine. 338 (4): 239-47. ... Hemoglobin is involved in the transport of other gases: It carries some of the body's respiratory carbon dioxide (about 20-25% ... William, C. Wilson; Grande, Christopher M.; Hoyt, David B. (2007). "Pathophysiology of acute respiratory failure". Trauma, ...
... respiratory insufficiency, seizures, unusual pupil size, dizziness,[14] headaches,[14] itching, hypothermia, bradycardia, ...
The affected person's respiratory rate often increases in the presence of respiratory distress. Pulse oximetry may confirm the ... AF can cause respiratory distress due to congestion in the lungs. By definition, the heart rate will be greater than 100 beats ...
Respiratory physiology සැකිල්ල:Gastrointestinal physiology සැකිල්ල:Integumentary physiology සැකිල්ල:Musculoskeletal physiology ... adrenal insufficiency: ACTH stimulation test Cushing's syndrome: Dexamethasone suppression test diabetes insipidus: Fluid ...
... s and signs relating to the respiratory system (R04-R07, 786). Medical examination and history taking ...
Hypoxic drive, a respiratory drive in which the body uses oxygen chemoreceptors to regulate the respiratory cycle ... respiratory minute volume. FEV1/FVC ratio. Lung function tests. spirometry. body plethysmography. peak flow meter. nitrogen ... This can be caused by alterations in respiratory drive, such as in respiratory alkalosis, physiological or pathological ... Robinson, Grace; Strading, John; West, Sophie (2009). Oxford Handbook of Respiratory Medicine. Oxford University Press. p. 880 ...
Respiratory dysfunction (in the absence of a cyanotic heart defect or a known chronic respiratory disease) *the ratio of the ... November 2012). "Etomidate is associated with mortality and adrenal insufficiency in sepsis: A meta-analysis*". Critical Care ... Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ...
Others report a recent infection, particularly respiratory tract infections associated with coughing.[1] Trauma has been ... Chronic venous insufficiency. *Chronic cerebrospinal venous insufficiency. *Superior vena cava syndrome. *Inferior vena cava ...
Of these, 93% reported being ill in the three weeks preceding the onset of Reye's syndrome, most commonly with a respiratory ... Aspirin for some patients with chronic renal insufficiency and some children with congestive heart failure was contraindicated. ...
Seminars in Respiratory and Critical Care Medicine. 38 (6): 718-725. doi:10.1055/s-0037-1608777. PMID 29262429.. ... Vertebrobasilar insufficiency *Subclavian steal syndrome. *brainstem: medulla *Medial medullary syndrome. *Lateral medullary ...
Renal Insufficiency in Terminal Respiratory Failure Br Med J 1958; 1 :872 ... Renal Insufficiency in Terminal Respiratory Failure. Br Med J 1958; 1 doi: https://doi.org/10.1136/bmj.1.5075.872 (Published 12 ...
Bronchopulmonary Dysplasia , Respiratory Insufficiency - Causes, Clinical features, Management Do you wish to consult ... Bronchopulmonary Dysplasia or Respiratory insufficiency Bronchopulmonary dysplasia (BPD) is a chronic lung disease of newborns ... Latest Publications and Research on Bronchopulmonary Dysplasia or Respiratory insufficiency. *Dose-escalation trial of ... Viral immunization - Babies with BPD are at increased risk of respiratory tract infections, especially respiratory syncytial ...
Respiratory Insufficiency. Respiratory Distress Syndrome, Adult. Respiration Disorders. Respiratory Tract Diseases. Lung ... Epidemiology of Respiratory Insufficiency in Critical Care (ERICC). The safety and scientific validity of this study is the ... We will perform an observational prospective study of patients admitted with acute respiratory insufficiency in several ICUs in ... Acute respiratory failure. Acute lung injury. Acute respiratory distress syndrome. Mechanical Ventilation. Non-Invasive ...
More respiratory care. What happens during normal breathing?. To understand what could be affecting your ability to breathe ... Learn more about other respiratory conditions such as COPD, NMD, or OHS that affect your ability to breathe or about ... respiratory conditions in children. Sleep studies. If your inability to breathe at night is causing you to have apnoeas (you ...
"Respiratory Insufficiency" by people in Harvard Catalyst Profiles by year, and whether "Respiratory Insufficiency" was a major ... "Respiratory Insufficiency" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Respiratory Insufficiency" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Respiratory Insufficiency". ...
Chronic respiratory insufficiency represents the advanced stage of a heterogeneous group of respiratory diseases, including ... The one glove fits all approach in offering telemonitoring for chronic respiratory insufficiency seems to be too simplistic ... This trial adds new fuel to the debate on optimal disease management for patients with chronic respiratory insufficiency. ... To date, the evidence as to whether telemonitoring is really effective in patients with chronic respiratory insufficiency seems ...
Telemonitoring in patients with chronic respiratory insufficiency: expectations deluded? Message subject: (Your Name) has ...
Daytime mechanical ventilation in chronic respiratory insufficiency. B Schonhofer, M Geibel, M Sonneborn, P Haidl, D Kohler ... Daytime mechanical ventilation in chronic respiratory insufficiency Message Subject (Your Name) has sent you a message from ... Chronic respiratory insufficiency (CRI) is associated with nocturnal hypoventilation. Treatment with noninvasive mechanical ... daytime mechanical ventilation in awake patients is equally effective at reversing chronic respiratory insufficiency. Since ...
Respiratory distress syndrome, the need for assisted ventilation, severe respiratory insufficiency, and death were ... Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants J Pediatr. 1993 ...
... and decrease hospitalization in patients with chronic respiratory failure. Most studies have involved small samples … ... Long-term follow-up in patients with severe chronic respiratory insufficiency Chest. 1994 Jan;105(1):100-5. doi: 10.1378/chest. ... and a reduction in days of hospitalization for respiratory illness (p , 0.0001) for , or = 2 years while receiving NIPPV. ... and decrease hospitalization in patients with chronic respiratory failure. Most studies have involved small samples of patients ...
Relapse of respiratory insufficiency one year after organising pneumonia. *J-M. Naccache 1 , ... the patient experienced relapsing severe respiratory insufficiency and basal opacities on the chest radiograph. Despite 2 ... The severity of respiratory failure, the evidence of a further evolution to UIP and the presence of anti-JO1 antibodies were ... European Respiratory Society. 442 Glossop Road. Sheffield S10 2PX. United Kingdom. Tel: +44 114 2672860. Email: [email protected] ...
Respiratory Insufficiency (Respiratory Failure) Summary Description: Failure to adequately provide oxygen to cells of the body ... Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) Show All ,, Key Therapies for Respiratory ... Key Drugs and Agents for Respiratory Insufficiency. Efficacy Chart ,, Drugs and Important Biological Agents (IBA) related to ... Also Known As: Respiratory Failure; Ventilatory Depression; Depressions, Ventilatory; Respiratory Depression. Networked: 13810 ...
What is the role of brainstem auditory evoked potential (BAEP) testing in the workup of respiratory insufficiency after ... Brainstem auditory evoked potentials in respiratory insufficiency following encephalitis. Int J Neurosci. 1996 Feb. 84(1-4):35- ... Halatek T, Sinczuk-Walczak H, Szymczak M. Neurological and respiratory symptoms in shipyard welders exposed to manganese. Int J ... 35] The auditory pathways are near the respiratory control centers in the brainstem; therefore, the electrophysiologic ...
Long-term follow-up in patients with severe chronic respiratory insufficiency.. Leger P1, Bedicam JM, Cornette A, Reybet-Degat ... and a reduction in days of hospitalization for respiratory illness (p , 0.0001) for , or = 2 years while receiving NIPPV. ... and decrease hospitalization in patients with chronic respiratory failure. Most studies have involved small samples of patients ... Respiratory Insufficiency/blood. *Respiratory Insufficiency/etiology. *Respiratory Insufficiency/physiopathology. *Respiratory ...
NIV initiation protocol for Chronic Respiratory Insufficiency or Failure. These are recommendations for NIV settings, but ... NIV initiation protocol for Chronic Respiratory Insufficiency or Failure (ResMed) ... Positive end expiratory pressure; PS: Pressure support; WOB: Work of breathing; OSA: Obstructive sleep apnea; RR: Respiratory ...
Respiratory Insufficiency. Pulmonary Valve Insufficiency. Lung Diseases, Obstructive. Respiratory Tract Diseases. Disease ... Diagnosis of chronic respiratory insufficiency including COPD and interstitial lung disease. *Requires use of continuous nasal ... In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency. This study has ... This will be a prospective, open-label, crossover study in up to 12 stable subjects with chronic respiratory insufficiency who ...
... announces the availability of the new bi-level ventilator BiPAP A401 for the management of chronic respiratory insufficiency, a ... New patient-centric solution for the management of chronic respiratory insufficiency diseases. ... New patient-centric solution for the management of chronic respiratory insufficiency diseases. by Philips ... Citation: New patient-centric solution for the management of chronic respiratory insufficiency diseases (2012, November 16) ...
Respiratory Insufficiency information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, ... What is Respiratory Insufficiency? *Videos related to Respiratory Insufficiency *Types of Respiratory Insufficiency *Causes of ... Diagnostic Tests for Respiratory Insufficiency *Home Testing and Respiratory Insufficiency *Signs of Respiratory Insufficiency ... Respiratory Insufficiency: Broader Related Topics. *Respiratory conditions *more types...» Types of Respiratory Insufficiency ...
... pathophysiology of respiratory failure and principles of respiratory care after surgical operations, trauma, hemorrhage, burns ... Post-traumatic pulmonary insufficiency : pathophysiology of respiratory failure and principles of respiratory care after ...
Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It ... Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It ... Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It ...
Bolton C.F. (1997) The Investigation of Respiratory Insufficiency in Nervous System Trauma and Sepsis. In: Schlag G., Redl H., ... Zifko UA, Bolton CF (1996) Electrophysiological monitoring in neurological respiratory insufficiency. J Neurol Neurosurg ... Bolton CF (1993b) Clinical neurophysiology of the respiratory system. AAEM Minimonograph #40. Muscle Nerve 16:809-818PubMed ... Chen R, GrandMaison F, Strong MJ, Ramsay DA, Bolton CF (1996) Motor neuron disease presenting as acute respiratory failure: a ...
Pulmonary Insufficiency, (Respiratory Failure) Lilly Schirmeister 13/11/2018. Bighorn Airways, Inc. is a diversified aviation ... Welcome once more to the Hub Pages Neighborhood! The mortality fee for grownup respiratory distress syndrome is roughly forty{ ...
Pulmonary Insufficiency, (Respiratory Failure) Lilly 02/11/2018. The airline made a revenue of USD 540 million last yr and new ...
Standard therapy was as effective as CPAP for acute hypoxemic nonhypercapnic respiratory insufficiency PDF. ACP J Club. 2001 ... 123 consecutive adults (median age 60 and 56 y in the 2 groups, 65% men) with respiratory insufficiency secondary to pulmonary ... In patients with acute hypoxemic nonhypercapnic respiratory insufficiency caused primarily by acute lung injury, is treatment ... Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a ...
In this interactive case, Joline Dalton, MS, CGC, presents a case on a 32-year-old Male With Progressive Weakness, Dilated Cardiomyopathy and Respiratory Insufficiency
Development of a Lung Rescue Team to Improve Care of Subjects With Refractory Acute Respiratory Failure Stefano Spina, Martin ... High-Flow Nasal Cannula May Not Reduce the Re-Intubation Rate after Extubation in Respiratory Failure Compared With a Large- ... Outcome of Frail Do-Not-Intubate Subjects With End-Stage Chronic Respiratory Failure and Their Opinion of Noninvasive ... Diaphragmatic Ultrasound Assessment in Subjects With Acute Hypercapnic Respiratory Failure Admitted to the Emergency Department ...
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An error signal (56) is computed that is the difference between a function of respiratory airflow (54) over a period of time ... Methods and apparatus for the systemic control of ventilatory support in the presence of respiratory insufficiency Download PDF ... Methods and apparatus for the systemic control of ventilatory support in the presence of respiratory insufficiency ... 230000000241 respiratory Effects 0.000 abstract description 13 * 0 C1[C](=C=[C](=C=*1)C)(C)* Chemical compound C1[C](=C=[C](=C ...
Project Relevance: This work is innovative because it will use gene therapy to target respiratory insufficiency (the main cause ... Home » Database » Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse Model ... Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse Model ... Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse Model ...
"Respiratory Insufficiency." Trauma, 8e Moore EE, Feliciano DV, Mattox KL. Moore E.E., Feliciano D.V., Mattox K.L. Eds. Ernest E ... Halaweish I, Delano M.J., Alam H.B. Halaweish, Ihab, et al.Respiratory Insufficiency. In: Moore EE, Feliciano DV, Mattox KL. ... Respiratory failure that relates primarily to CNS injury is discussed at length in other chapters and will not be extensively ... The above increase in respiratory demand might be met by a healthy adult; however, the injured patient faces several challenges ...
  • Acute respiratory failure is a common entity in intensive care units nowadays and is associated with significant morbidity and mortality, thus representing a major health problem. (clinicaltrials.gov)
  • Respiratory Failure following Abdominal Wall Reconstruction: An Analysis of the Nationwide Inpatient Sample. (harvard.edu)
  • Curley MAQ, Gedeit RG, Dodson BL, Amling JK, Soetenga DJ, Corriveau CO, Asario LA, Wypij D. Methods in the design and implementation of the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial. (harvard.edu)
  • Breathlessness in amyotrophic lateral sclerosis: A case report on the role of osteoporosis in the worsening of respiratory failure. (harvard.edu)
  • Philip S, Apostolou D. Aortic Valve Rupture: An Important Cause of Ventilator-Dependent Respiratory Failure after Blunt Chest Trauma. (harvard.edu)
  • Factors Predictive of Postoperative Acute Respiratory Failure Following Inpatient Sinus Surgery. (harvard.edu)
  • Pediatric Specialty Care Model for Management of Chronic Respiratory Failure: Cost and Savings Implications and Misalignment With Payment Models. (harvard.edu)
  • Intraoperative Acute Respiratory Failure in an Immunocompromised Patient with Human Metapneumovirus. (harvard.edu)
  • Prior studies have shown that nasal intermittent positive pressure ventilation (NIPPV) can improve arterial blood gas values, prevent symptoms resulting from alveolar hypoventilation, and decrease hospitalization in patients with chronic respiratory failure. (nih.gov)
  • As a result of rapidly progressive respiratory failure, she was admitted to the intensive care unit. (ersjournals.com)
  • Life-threatening respiratory failure that develops rapidly. (wikidata.org)
  • Chen R, Remtulla H, Power K, Collins S, Bolton CF (1995b) Needle EMG of the human diaphragm: power spectral analysis in normal subjects and in patients with respiratory failure. (springer.com)
  • Chen R, Grand'Maison F, Strong MJ, Ramsay DA, Bolton CF (1996) Motor neuron disease presenting as acute respiratory failure: a clinical and pathological study. (springer.com)
  • However, all forms of noninvasive ventilation, including CPAP, require scrupulous clinical monitoring so that endotracheal intubation and mechanical ventilation are instituted promptly before life-threatening respiratory failure becomes imminent and to avoid emergency intubation or cardiopulmonary arrest. (acpjc.org)
  • Death due to respiratory failure occurs within 2-3 years for patients with bulbar onset ALS and 3-5 years for limb onset cases. (neurodegenerationresearch.eu)
  • AAV gene therapy is now in clinical trials and if successful, this therapy will provide a therapeutic option for respiratory failure in the patients with mutations in the SOD1 gene. (neurodegenerationresearch.eu)
  • Respiratory failure that relates primarily to CNS injury is discussed at length in other chapters and will not be extensively covered here. (mhmedical.com)
  • Patients from high risk group with circulatory insufficiency, respiratory failure pose a problem. (readbyqxmd.com)
  • The syndrome of acute respiratory failure has different causes of occurrence. (doctorsask.com)
  • The emergence of symptoms of acute respiratory failure requires the provision of emergency care and further hospitalization. (doctorsask.com)
  • The syndrome of acute respiratory failure can be caused by many factors and has its own characteristic features. (doctorsask.com)
  • Causes of acute respiratory failure can be of two types: extrapulmonary and pulmonary. (doctorsask.com)
  • Respiratory compromise is a state in which there is a high likelihood of decompensation into respiratory insufficiency, respiratory failure, respiratory arrest or death, but in which specific interventions (continuous monitoring and therapies) might prevent or mitigate decompensation. (medtronic.com)
  • The ideal treatment for respiratory failure in NMD patients is non-invasive ventilation (NIV). (resmed.com)
  • A pragmatic randomised controlled trial to determine whether Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) and lower tidal volume mechanical ventilation in patients with hypoxaemic respiratory failure improves 90 day mortality NB! (prismtrial.org)
  • BACKGROUND: Non-invasive ventilation is part of the standard of care for treatment of respiratory failure in patients with amyotrophic lateral sclerosis (ALS). (ox.ac.uk)
  • The NeuRx RA/4 Diaphragm Pacing System has received Humanitarian Device Exemption approval from the US Food and Drug Administration for treatment of respiratory failure in patients with ALS. (ox.ac.uk)
  • Our results suggest that diaphragmatic pacing should not be used as a routine treatment for patients with ALS in respiratory failure. (ox.ac.uk)
  • Chronic obstructive pulmonary disease (COPD) is associated with the development of respiratory failure, which, in turn, exposes the tissues to oxidative stress, which is both a cause and a result of respiratory insufficiency. (cdc.gov)
  • It is unknown whether genetic variability of the enzymes protecting against reactive oxygen species (ROS) can influence the development of respiratory failure in COPD patients. (cdc.gov)
  • The aim of the study was to determine the correlation between polymorphism of MnSOD signal peptide and the occurrence of respiratory failure in the course of COPD. (cdc.gov)
  • Respiratory failure was diagnosed in 42 COPD patients. (cdc.gov)
  • Respiratory failure in the course of COPD also correlates with lower expression of MnSOD mRNA. (cdc.gov)
  • The presence of valine at position 9 of the MnSOD signal peptide encoded by exon 2 is a risk factor for the occurrence of respiratory failure in the course of COPD in the Polish population. (cdc.gov)
  • Multiple clinical studies have evaluated this technology, the strongest evidence to date supporting its use being the Conventional Ventilation or ECMO for Severe Adult Respiratory Failure (CESAR) trial, which showed survival advantage when patients were treated with a protocol that included ECMO. (springer.com)
  • It is a primary treatment for hypercarbic respiratory failure or is an adjunct to reduce potentially injurious levels of mechanical ventilator support in hypoxemic respiratory failure. (springer.com)
  • Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. (springer.com)
  • Extracorporeal circulation (ECMO) in neonatal respiratory failure. (springer.com)
  • Extracorporeal membrane oxygenation in severe acute respiratory failure. (springer.com)
  • Following cardiac surgery, patients can develop acute respiratory failure. (elsevier.com)
  • We present the case of a 66-year-old male successfully treated with extracorporeal venovenous membrane oxygenation (vvECMO) for acute respiratory failure postsurgery and review the literature on vvECMO in this specific setting. (elsevier.com)
  • Multivariate analysis showed that two frequent SFTPA2 missense alleles (rs1965708-C and rs1059046-A) and the SFTPA2 haplotype 1A(0) were associated with a need for mechanical ventilation, acute respiratory failure, and acute respiratory distress syndrome. (cdc.gov)
  • After discharge, she developed respiratory failure due to a viral infection at 8 months of her age. (bvsalud.org)
  • A system and method for evaluating a patient status from sampled physiometry for use in respiratory insufficiency management and heart failure assessment is presented. (justia.com)
  • Each such trend is compared to applicable indications of worsening heart failure and respiratory insufficiency to generate a notification of parameter violations. (justia.com)
  • The present invention relates in general to heart failure assessment, and, in particular, to a system and method for managing respiratory insufficiency in conjunction with heart failure assessment. (justia.com)
  • Common causes of respiratory insufficiency include bronchitis, emphysema, pneumonia, pulmonary emboli, congestive heart failure, tumor infiltration of the lung and abnormalities of the interstitium of the lungs that may be infectious in origin, due to immunological abnormalities, or as a result of exposure to environmental pathogens. (justia.com)
  • The effects of respiratory insufficiency range from cough to impairment during physical exertion to a complete failure of lung function and respiratory arrest at any level of activity. (justia.com)
  • Respiratory arrest should be distinguished from respiratory failure. (wikipedia.org)
  • The former refers to the complete cessation of breathing, while respiratory failure is the inability to provide adequate ventilation for the body's requirements. (wikipedia.org)
  • Respiratory arrest is also different from cardiac arrest, the failure of heart muscle contraction. (wikipedia.org)
  • In the last decade, several studies focusing on the effects of various tele-management programmes for patients with chronic respiratory insufficiency (with COPD being the main diagnosis) have been published. (bmj.com)
  • Her complicated diagnosis was: acute respiratory insufficiency with recent results of right mediobasal bronchopneumonic foci with respiratory distress, Hypertensive hypertrophic heart disease, Renal insufficiency, Anemia, Drained left PNX, Tracheomalacia, and Gastritis, and various medical procedures were performed, including Tracheostomy. (doctorsmedicalopinion.com)
  • Like the hypothalamic-pituitary disorders, early diagnosis of the initial or partial stages of primary adrenocortical insufficiency has an important role. (thefreedictionary.com)
  • Several factors make the early diagnosis and prevention of respiratory insufficiency, as well as the monitoring of the progression of respiratory insufficiency, relatively difficult. (justia.com)
  • Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. (medtronic.com)
  • Postoperative Pulmonary Complications - Management of Postoperative Respiratory Insufficiency is a topic covered in the Clinical Anesthesia Procedures . (unboundmedicine.com)
  • Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728517/all/Postoperative_Pulmonary_Complications___Management_of_Postoperative_Respiratory_Insufficiency. (unboundmedicine.com)
  • Complications from respiratory compromise are increasing rapidly across the clinical spectrum, partly due to expanded use of opioids combined with the lack of standardized guidelines among medical specialties. (wikipedia.org)
  • We will perform an observational prospective study of patients admitted with acute respiratory insufficiency in several ICUs in Brazil. (clinicaltrials.gov)
  • Respiratory distress syndrome, the need for assisted ventilation, severe respiratory insufficiency, and death were significantly more common among infected than among noninfected infants. (nih.gov)
  • In September 1999, whilst the corticosteroid dose was tapered to 7 mg·day −1 , the patient experienced relapsing severe respiratory insufficiency and basal opacities on the chest radiograph. (ersjournals.com)
  • The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). (springer.com)
  • Extracorporeal life support for severe acute respiratory distress syndrome in adults. (springer.com)
  • Treatment of severe acute respiratory distress syndrome: role of extracorporeal gas exchange. (springer.com)
  • In approximately 10 percent of patients, myasthenic crisis or sudden severe weakness of the jaw and throat (oropharyngeal) or respiratory muscles occurs, requiring respiratory assistance. (rarediseases.org)
  • Respiratory arrest is caused by apnea (cessation of breathing) or respiratory dysfunction severe enough it will not sustain the body (such as agonal breathing). (wikipedia.org)
  • Obstructive conditions of the lower airway, including severe asthma or COPD episodes, can also lead to respiratory arrest. (wikipedia.org)
  • BPD was first described in 1967 by Northway et al who noticed the development of a new chronic lung disease in a set of premature infants who suffered from respiratory distress syndrome (RDS) and received ventilation with high levels of oxygen. (medindia.net)
  • 3 and (6) the opportunity that telemonitoring offers of early remote detection of signs and symptoms of chronic respiratory insufficiency decompensation, 4 and at-distance tailoring and monitoring of mechanical ventilation and education reinforcement for the patient and caregiver. (bmj.com)
  • In this issue of Thorax , Chatwin et al 10 reported a randomised crossover trial with 6 months of standard best practice clinical care (control) and 6 months with the addition of telemonitoring, in which 68 patients with chronic respiratory insufficiency (38 with COPD) with or without home mechanical ventilation received telemonitoring (a second-generation system) via a broadband link to a hospital-based care team. (bmj.com)
  • We conclude that in many respects, when compared to nocturnal mechanical ventilation, daytime mechanical ventilation in awake patients is equally effective at reversing chronic respiratory insufficiency. (ersjournals.com)
  • 90%. 61 patients received no additional respiratory interventions, and 62 received CPAP for 6 to 12 h/d until they no longer required it or they needed intubation and mechanical ventilation. (acpjc.org)
  • The groups did not differ for any other outcomes at any time point: respiratory indices, need for intubation (34% in the CPAP group vs 39% in the oxygen group, P = 0.5), median duration of ventilation, median ICU stay (6.5 vs 6.0 d, P = 0.4), ICU mortality (21% vs 26%, P = 0.6), and hospital mortality (31% vs 30%, P = 0.9). (acpjc.org)
  • Despite some early improvement in oxygenation and symptoms, continuous positive airway pressure was no more effective than standard oxygen therapy for the eventual need for intubation, duration of ventilation, length of hospital stay, or mortality in patients with acute hypoxemic nonhypercapnic respiratory insufficiency primarily caused by acute lung injury. (acpjc.org)
  • The immediate goal of managing a patient with respiratory insufficiency is to ensure adequate oxygenation and ventilation. (unboundmedicine.com)
  • Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. (springer.com)
  • Clinically, respiratory insufficiency involves either difficulty in ventilation or in oxygenation. (justia.com)
  • To save a patient suffering from respiratory arrest, the goal is to restore adequate ventilation and prevent further damage. (wikipedia.org)
  • Mouton, R & Einav, S 2021, ' Continuous positive airway pressure after major abdominal surgery: an independent discussion of the Prevention of Respiratory Insufficiency after Surgical Management trial ', British Journal of Anaesthesia , vol. 127, no. 2, pp. 310-315. (bris.ac.uk)
  • The airway and lung damage can lead to or aggravate respiratory distress syndrome (RDS) . (medindia.net)
  • BPD occurs most often due to respiratory distress syndrome (RDS), common complication in preterm infants. (medindia.net)
  • The syndrome of acute respiratory distress syndrome (ARDS) and current management is a major focus. (mhmedical.com)
  • acute respiratory insufficiency with recent results of right mediobasal bronchopneumonic foci with respiratory distress. (doctorsmedicalopinion.com)
  • Acute Respiratory Distress Syndrome (Health And Medical Video 2018). (doctorsask.com)
  • Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study. (springer.com)
  • Clinical manifestations of respiratory insufficiency include respiratory distress, such as shortness of breath and fatigue, cough, and reduced exercise capacity or tolerance. (justia.com)
  • Chronic respiratory insufficiency represents the advanced stage of a heterogeneous group of respiratory diseases, including COPD, which have an associated high cost burden. (bmj.com)
  • Philips Respironics today announces the availability of the new bi-level ventilator BiPAP A401 for the management of chronic respiratory insufficiency, a condition secondary to diseases such as obesity hypoventilation syndrome, chronic obstructive pulmonary disease (COPD) and neuromuscular disease for adult and pediatric patients (above 10 kg). (medicalxpress.com)
  • Launching on World COPD Day 2012 and being showcased this week at Medica 2012, the world's largest medical trade fair, the BiPAP A40 improves the management of chronic respiratory diseases by offering a range of unique benefits that facilitate the smoothest possible transition in the patient care pathway - from initial titration to hospital discharge , from home therapy to long-term follow-up. (medicalxpress.com)
  • Although many chronic respiratory diseases are preventable and can be effectively managed, they continue to be an important cause of morbidity, mortality and the increased health care costs worldwide. (medicalxpress.com)
  • more visits during this period were for infectious diseases or mental and behavioral health-related concerns and fewer visits were for gastrointestinal and upper-respiratory-related illnesses compared with ED visits during December 2019-January 2020. (cdc.gov)
  • Presently, respiratory insufficiency due to primary diseases of the lungs is one of the leading causes of acute and chronic illness in the world. (justia.com)
  • For purposes of this invention, the term "respiratory insufficiency" will refer to ventilatory insufficiency and/or to problems in oxygenation due to diseases of the lung. (justia.com)
  • Medication may suppress respiration in the elderly, the very ill, and those patients with respiratory problems, therefore lower doses may be required. (rxlist.com)
  • Learn more about other respiratory conditions such as COPD , NMD , or OHS that affect your ability to breathe or about respiratory conditions in children . (resmed.com)
  • The sequence polymorphism of MnSOD gene in subjects with respiratory insufficiency in COPD. (cdc.gov)
  • It was suggested that management of the respiratory muscle strength, exercise tolerance, and ADL when COPD patients are obese rather than thin can be possibly associated with a higher QOL. (nii.ac.jp)
  • Complex cardiac arrhythmia, heart murmurs, hypotension, angina-like chest pain, respiratory insufficiency or distention of the jugular veins may indicate potential cardiac injury. (readbyqxmd.com)
  • [3] In children, however, only doing compressions may result in worse outcomes, because in children the problem normally arises from a respiratory, rather than cardiac problem. (wikipedia.org)
  • Any trends are identified and include one of a status quo and a change, which might affect cardiac performance or respiratory performance. (justia.com)
  • If respiratory arrest remains without any treatment, cardiac arrest will occur within minutes of hypoxemia, hypercapnia or both. (wikipedia.org)
  • Respiratory insufficiency, sometimes referred to as pulmonary insufficiency, is a condition in which the lungs fail to adequately provide oxygen and/or remove carbon dioxide from the body. (medtronic.com)
  • What is the role of brainstem auditory evoked potential (BAEP) testing in the workup of respiratory insufficiency after encephalitis? (medscape.com)
  • Multiparametric neuromonitoring was performed in a 60-year-old patient after heart transplantation and respiratory insufficiency following encephalitis. (ispub.com)
  • The standard short high-dose (250 [micro] g) adrenocorticotropic hormone (ACTH) stimulation test (HDST) with synthetic ACTH is the most widely used test for the detection of primary or prolonged secondary adrenocortical insufficiency (1). (thefreedictionary.com)
  • : S643 If a person still has a pulse but is not breathing ( respiratory arrest ) artificial ventilations may be more appropriate, but, due to the difficulty people have in accurately assessing the presence or absence of a pulse, CPR guidelines recommend that lay persons should not be instructed to check the pulse, while giving healthcare professionals the option to check a pulse. (wikipedia.org)
  • If the heart muscle contraction is intact, the condition is known as respiratory arrest. (wikipedia.org)
  • Brain injury is likely if respiratory arrest goes untreated for more than three minutes, and death is almost certain if more than five minutes. (wikipedia.org)
  • Respiratory arrest is a life-threatening medical emergency that requires immediate medical attention and management. (wikipedia.org)
  • In some instances, an impending respiratory arrest could be predetermined by signs the patient is showing, such as the increased work of breathing. (wikipedia.org)
  • Respiratory arrest will ensue once the patient depletes their oxygen reserves and loses the effort to breathe. (wikipedia.org)
  • One common symptom of respiratory arrest is cyanosis, a bluish discoloration of the skin resulting from an inadequate amount of oxygen in the blood. (wikipedia.org)
  • One of the ways the body attempts to compensate for these increased respiratory demands is by increasing respiratory rate, which in turn worsens respiratory muscle fatigue of the diaphragm and can eventually lead to respiratory arrest and death without timely medical intervention. (wikipedia.org)
  • Halatek T, Sinczuk-Walczak H, Szymczak M. Neurological and respiratory symptoms in shipyard welders exposed to manganese. (medscape.com)
  • More detailed information about the symptoms , causes , and treatments of Respiratory Insufficiency is available below. (rightdiagnosis.com)
  • Symptoms of respiratory compromise can differ with each patient. (wikipedia.org)
  • ResMed's advanced data collection capabilities (device and card data storage with high-resolution flow and pressure data, percentage of spontaneous breaths, AHI, volumes, respiratory rate, synchronisation details, SpO 2 monitoring) and ResScan TM software allow clinicians to have detailed data for troubleshooting and monitoring patient progress. (resmed.com)
  • The syndrome of acute respiratory insufficiency is a pathological condition characterized by a sharp change in the process of gas exchange in the lungs. (doctorsask.com)
  • As diaphragm and respiratory muscle weakness progress, targeted respiratory therapy with non-invasive ventilatory support improves survival. (neurodegenerationresearch.eu)
  • This application proposes to study the impact of respiratory directed gene therapy on spontaneous breathing, pulmonary mechanics, and respiratory efferent nerve output. (neurodegenerationresearch.eu)
  • In addition, this proposal aims to study the impact of respiratory targeted and systemic gene therapy on pulmonary physiology and neurophysiology outcome measures as well as behavioral testing and survival. (neurodegenerationresearch.eu)
  • ANCHOR=],[LINK=]) In clinical studies evaluating the incidence or impact of respiratory insufficiency, the condition may be defined in a variety of ways, such as: a decrease in respiratory rate, a reduction in oxygen saturation of hemoglobin, or as a change in arterial blood gasses. (medtronic.com)
  • In patients with acute hypoxemic nonhypercapnic respiratory insufficiency caused primarily by acute lung injury, is treatment with continuous positive airway pressure (CPAP) delivered by a face mask as safe and effective as standard oxygen alone for improving clinical outcomes? (acpjc.org)
  • Patients with acute hypoxemic nonhyercapnic respiratory insufficiency may benefit from maintaining CPAP as continuously as possible, given the potential for rapid deterioration after the decrease or removal of positive end-expiratory pressure. (acpjc.org)
  • First, the central nervous system may be impaired, resulting in inadequate respiratory drive, or inability to maintain patent proximal airways. (mhmedical.com)
  • ileocecal insufficiency inability of the ileocecal valve to prevent backflow of contents from the cecum into the ileum. (thefreedictionary.com)
  • Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask. (acpjc.org)
  • venous insufficiency inadequacy of the venous valves and impairment of venous return from the lower limbs ( venous stasis ), often with edema and sometimes with stasis ulcers at the ankle. (thefreedictionary.com)
  • Decreased respiratory effort: Central nervous system impairment leads to decreased respiratory effort. (wikipedia.org)
  • In conclusion, L-ficolin may confer some protection from microorganisms that exacerbate allergic inflammation in the lung and its relative deficiency may contribute to enhanced susceptibility to respiratory infections. (semanticscholar.org)
  • Following the development of serious respiratory depression (post tracheotomy tracheal stenosis), she underwent Montgomery T-tube insertion, and after 2 weeks developed distal obstruction with dense mucous secretions, and was changed to a Bivona trach. (doctorsmedicalopinion.com)
  • Following the development of serious respiratory depression (post tracheotomy tracheal stenosis), the patient was again transferred to the department of Pulmonary Medicine on June 2008. (doctorsmedicalopinion.com)
  • Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration. (medtronic.com)
  • The measurement items were: respiratory function, respiratory muscle strength, lower and upper limb muscle strength, the 30-sec chair-stand test (CS-30), timed up and go test (TUG), 6-minute walking test (6MWT), incremental shuttle walking test (ISWT), Nagasaki university respiratory questionnaire (NRADL), and St. George's respiratory questionnaire (SGRQ). (nii.ac.jp)
  • The incidence of respiratory insufficiency ranges from 5% to 41% of patients. (medtronic.com)
  • We previously reported an association between relative L-ficolin deficiency and recurrent respiratory infections co-existing with allergic disorders in children. (semanticscholar.org)
  • The maintenance of gas exchange may be tenuous in the injured patient because of dysfunction in three key elements of the respiratory system. (mhmedical.com)
  • CNS dysfunction from injury impairs respiratory drive, as do many medications routinely used for sedation and analgesia. (mhmedical.com)
  • velopharyngeal insufficiency inadequate velopharyngeal closure , due to a condition such as cleft palate or muscular dysfunction, resulting in defective speech. (thefreedictionary.com)
  • Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial. (ox.ac.uk)
  • The Breathe NIOV™ System will reduce the work of breathing in subjects with chronic respiratory insufficiency who require long-term oxygen therapy (LTOT). (clinicaltrials.gov)
  • Chronic respiratory insufficiency (CRI) is associated with nocturnal hypoventilation. (ersjournals.com)
  • Advantages of delayed-action intermittent corticotherapy in the treatment of asthma and chronic respiratory insufficiency]. (semanticscholar.org)
  • Patients that undergo the gastric weight loss surgery reportedly encounter less respiratory problems like asthma. (selfgrowth.com)