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ReserpineIproniazidTyramineMethyltyrosinesalpha-MethyltyrosineAdrenergic Uptake InhibitorsNorepinephrineHydroxydopaminesTetrabenazineChlorpromazineMephenterminePargylineCatecholamine Plasma Membrane Transport ProteinsSecologanin Tryptamine AlkaloidsCatecholaminesBiogenic AminesSympathomimeticsNialamideAdrenal MedullaVesicular Monoamine Transport ProteinsPituitary IrradiationBretylium CompoundsVesicular Biogenic Amine Transport ProteinsSerotoninNormetanephrineFenclonineChromaffin GranulesMonoamine Oxidase Inhibitors17-HydroxycorticosteroidsMethyldopaPharmacologyPhenoxybenzamineSynephrineMethysergideDopamineChromaffin SystemClopamideVas DeferensTranylcypromineChlorisondamineTranquilizing AgentsGuanethidineDesipramine5-HydroxytryptophanDextroamphetamineEphedrineMetaraminolEpinephrineDihydroxyphenylalanineAdrenergic AgentsEncyclopedias as TopicBiogenic MonoaminesMonoamine OxidaseAntihypertensive AgentsIndole Alkaloids
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Iproniazid: An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.Methyltyrosines: A group of compounds that are methyl derivatives of the amino acid TYROSINE.alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)Adrenergic Uptake Inhibitors: Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Hydroxydopamines: Dopamines with a hydroxy group substituted in one or more positions.Tetrabenazine: A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.Mephentermine: A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.Catecholamine Plasma Membrane Transport Proteins: A group of membrane transport proteins that transport biogenic amine derivatives of catechol across the PLASMA MEMBRANE. Catecholamine plasma membrane transporter proteins regulate neural transmission as well as catecholamine metabolism and recycling.Secologanin Tryptamine Alkaloids: Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Sympathomimetics: Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.Nialamide: An MAO inhibitor that is used as an antidepressive agent.Adrenal Medulla: The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.Vesicular Monoamine Transport Proteins: A family of vesicular amine transporter proteins that catalyze the transport and storage of CATECHOLAMINES and indolamines into SECRETORY VESICLES.Pituitary Irradiation: Radiation therapy used to treat the PITUITARY GLAND.Bretylium CompoundsVesicular Biogenic Amine Transport Proteins: Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Normetanephrine: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.Chromaffin Granules: Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.Monoamine Oxidase Inhibitors: A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)17-Hydroxycorticosteroids: A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.Methyldopa: An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.Synephrine: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.Methysergide: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Chromaffin System: The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.Clopamide: A sulfamoylbenzamide piperidine. It is considered a thiazide-like diuretic.Vas Deferens: The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)Chlorisondamine: A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Metaraminol: A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.Adrenergic Agents: Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Monoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Indole Alkaloids: Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)

Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart. (1/855)

[11C]Phenylephrine (PHEN) is a radiolabeled analogue of norepinephrine that is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and taken up into storage vesicles localized within the nerve varicosities by the vesicular monoamine transporter. PHEN is structurally related to two previously developed sympathetic nerve markers: [11C]-meta-hydroxyephedrine and [11C]epinephrine. To better characterize the neuronal handling of PHEN, particularly its sensitivity to neuronal monoamine oxidase (MAO) activity, kinetic studies in an isolated working rat heart system were performed. METHODS: Radiotracer was administered to the isolated working heart as a 10-min constant infusion followed by a 110-min washout period. Two distinctly different approaches were used to assess the sensitivity of the kinetics of PHEN to MAO activity. In the first approach, oxidation of PHEN by MAO was inhibited at the enzymatic level with the MAO inhibitor pargyline. In the second approach, the two hydrogen atoms on the a-carbon of the side chain of PHEN were replaced with deuterium atoms ([11C](-)-alpha-alpha-dideutero-phenylephrine [D2-PHEN]) to inhibit MAO activity at the tracer level. The importance of vesicular uptake on the kinetics of PHEN and D2-PHEN was assessed by inhibiting vesicular monoamine transporter-mediated storage into vesicles with reserpine. RESULTS: Under control conditions, PHEN initially accumulated into the heart at a rate of 0.72+/-0.15 mL/min/g wet. Inhibition of MAO activity with either pargyline or di-deuterium substitution did not significantly alter this rate. However, MAO inhibition did significantly slow the clearance of radioactivity from the heart during the washout phase of the study. Blocking vesicular uptake with reserpine reduced the initial uptake rates of PHEN and D2-PHEN, as well as greatly accelerated the clearance of radioactivity from the heart during washout. CONCLUSION: These studies indicate that PHEN kinetics are sensitive to neuronal MAO activity. Under normal conditions, efficient vesicular storage of PHEN serves to protect the tracer from rapid metabolism by neuronal MAO. However, it is likely that leakage of PHEN from the storage vesicles and subsequent metabolism by MAO lead to an appreciable clearance of radioactivity from the heart.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/855)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

A possible mode of cardiovascular actions of dopamine in dogs. (3/855)

A possible mode of cardiovascular actions of dopamine was studied using ephedrine. In the dog pretreated with repeated administrations of ephedrine (total dose, 40 or 80 mg/kg, i.v.) or with combined administrations of ephedrine (total dose, 90 mg/kg, s.c. and i.v.) and reserpine (2 mg/kg, s.c., 24 hr previously), pressor responses to dopamine were eliminated and reversed to depressor responses whereas depressor responses to dopamine were potentiated. Positive chronotropic effects of dopamine were almost eliminated. Pressor and positive chronotropic effects of tyramine were almost abolished. Sympathomimetic effect of noradrenaline and adrenaline were potentiated while those of isoprenaline were inhibited. In the heart-lung preparation of ephedrine-treated dogs (total dose, 40 mg/kg, i.v.), cardiac stimulating effects of dopamine and tyramine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent. In the open-chest dogs, after pretreatment of cocaine (4 mg/kg, i.v.), pressor, positive inotropic and chronotropic effects of noradrenaline were potentiated, whilst those of tyramine were inhibited. Those of dopamine were not visibly altered, but depressor, negative chronotropic and inotropic effects of dopamine appeared at small doses. In the ephedrine-pretreated dogs, these sympathomimetic effects of dopamine and tyramine after cocaine were strongly depressed and those of noradrenaline were inhibited to a certain degree. The results obtained with ephedrine suggest that dopamine differs from other catecholamines and tyramine in the mode of cardiovascular actions.  (+info)

Pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2-(3H)-furylidene]-1,3-cyclopentanedione (oudenone). (4/855)

The pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2(3H)-furylidene]-1,3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10--40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized rats. In unanesthetized spontaneously hypertensive rats (SHR), oudenone (5--200 mg/kg p.o.) caused a dose-related decrease in the systolic blood pressure. The initial pressor effect was diminished by pretreatments with phentolamine, guanethidine, hexamethonium and was abolished in the pithed rats. In addition, intracisternal administrations of oudenone (100--600 mug/kg) showed a marked increase in blood pressure in the anesthetized rats, suggesting that the pressor effect may be due to centrally mediated actions. Oudenone, given intra-arterially into the femoral artery (400--800 mug/kg), caused a long-lasting vasodilation in anesthetized dogs. At a relatively high dose (40 mg/kg i.v.), oudenone antagonized all pressor responses to autonomic agents and central vagus nerve stimulation in anesthetized rats and dogs, however, oudenone showed no anti-cholinergic,-histaminergic, beta-adrenergic and adrenergic neuron blocking properties.  (+info)

The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. (5/855)

The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether beta-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that beta3-adrenergic receptors and classical beta1/beta2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue.  (+info)

The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (6/855)

In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested.  (+info)

Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. (7/855)

Methamphetamine (METH) is a powerful psychostimulant that is increasingly abused worldwide. Although it is commonly accepted that the dopaminergic system and oxidation of dopamine (DA) play pivotal roles in the neurotoxicity produced by this phenylethylamine, the primary source of DA responsible for this effect has remained elusive. In this study, we used mice heterozygous for vesicular monoamine transporter 2 (VMAT2 +/- mice) to determine whether impaired vesicular function alters the effects of METH. METH-induced dopaminergic neurotoxicity was increased in striatum of VMAT2 +/- mice compared with wild-type mice as revealed by a more consistent DA and metabolite depletion and a greater decrease in dopamine transporter expression. Interestingly, increased METH neurotoxicity in VMAT2 +/- mice was accompanied by less pronounced increase in extracellular DA and indices of free radical formation compared with wild-type mice. These results indicate that disruption of vesicular monoamine transport potentiates METH-induced neurotoxicity in vivo and point, albeit indirectly, to a greater contribution of intraneuronal DA redistribution rather than extraneuronal overflow on mediating this effect.  (+info)

Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine. (8/855)

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.  (+info)

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A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. Subsequently, amine levels recovered slowly, but remained depressed 6 months after reserpine injection. Following reserpine treatment, glyoxylic acid-induced fluorescence or neutral red staining closely mirrored the HPLC-determined time course of amine depletion and recovery. Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. The threshold concentration of reserpine necessary to produce amine depletion was approximately 1 microM. We found that reserpine treatment eliminated biting behavior within 4 d following injection. Biting behavior ...
Treatment of Hypertension with Reserpine,with Reserpine in Combination with Pentapyrrolidinium,and with Reserpine in...Treatment of Hypertension with Reserpine,with Reserpine in Combination with Pentapyrrolidinium,and with Reserpine in...
The treatment of hypertension with reserpine is described. When used alone it produced adequatefalls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its parasympathetic side effects. The combination of reserpine and pentapyrrolidinium is regarded as the best therapeutic regime for severe hypertension. Some mild cases of hypertension may be managed with reserpine alone.. ...
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Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocker reserpine was previously shown to increase enkephalin levels several-fold. To explore the biochemical mechanism of this effect, we examined the effect of reserpine treatment on the activities of three different peptide precursor processing enzymes: carboxypeptidase E (CPE) and the prohormone convertases (PCs) PC1/3 and PC2. Reserpine treatment increased both CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered for any enzyme. Further analysis showed that the increase in CPE activity was due to an elevated Vmax, with no change in the Km for substrate hydrolysis or the levels of CPE mRNA. Reserpine activation of endogenous processing enzymes was also observed in extracts prepared from PC12 cells stably expressing PC1/3 or PC2. In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3 and PC2, with dopamine quinone the most ...
Migren Benzeri Atakta Uyarılmış İşitsel Beyin Sapı Potansiyelleri: Deneysel Hayvan ModeliMigren Benzeri Atakta Uyarılmış İşitsel Beyin Sapı Potansiyelleri: Deneysel Hayvan Modeli
Serotonin is known as one of the most important neurotransmitters. This amine structured neurotransmitter Ievel is influenced in migraine. Plasma serotonin Ievel is essentially decreased during migraine atacks. It is known that reserpine has an amine-releasing effect. In this study, migraine-Iike episodes were constituted in thirty-three guinea pigs by intraperitoneal reserpine administration. Then the auditory brainstem evoked potentials were recorded. All absolute and interpeak lalency values were initially increased at the second hour of reserpine administration and reached to the maximum values at third hour, and then gradually decreased up to twelfth hour. This result mainly reflects the brainstem involvement in migraine-Iike attack induced by reserpine administration. Subsequent Iatency parameters which are close to baseline values may be attributed to the fact that these changes are temporary and follow the variations in the serotonin Ievels. . ...
Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte...Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte...
It has been suggested that reserpine blocks expression of delayed hypersensitivity (DH) by depleting tissue mast cells of serotonin (5-HT), thereby preventing a T cell-dependent release of mast cell 5-HT necessary to localize and to amplify the DH response. However, reserpine blocks expression of DH in mast cell-deficient mice. We therefore decided to reevaluate the mechanism by which reserpine abrogates expression of cellular immunity, and investigated whether the drug might interfere with T cell activity in vitro or in vivo. At concentrations as low as 4 microM, reserpine profoundly suppressed baseline or antigen-augmented levels of [3H]thymidine incorporation by immune lymph node cells obtained from mice sensitized to the contactant oxazolone [I-LNC(Ox)]. This effect was observed both with I-LNC derived from normal mice and with I-LNC derived from congenitally mast cell-deficient W/Wv mice, cell preparations that lacked detectable mast cells, histamine, and 5-HT. Furthermore, treatment of ...
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Mechanism of reserpine-induced acute gastric mucosal injury in the rat: role of endogenous 5-hydroxytryptamine | Clinical...Mechanism of reserpine-induced acute gastric mucosal injury in the rat: role of endogenous 5-hydroxytryptamine | Clinical...
1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm2, mean ± SEM). Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5-15 mg/kg) did not influence these effects of reserpine, but vagotomy protected the rats against them. The α-adrenoceptor-blocking drugs phenoxybenzamine and phentolamine at 5 mg/kg were protective against injury. However, a 10 mg/kg dose of either blocker was more effective (2.2 ± 0.5 mm2 and 3 ± 0.8 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM, P ,0.01) and a dose of 15 mg/kg afforded complete protection.. 2. Methysergide, a 5-hydroxytryptamine receptor antagonist, produced a dose-dependent increase in the reserpine-induced injury; a significant (P ,0.05) increase was noted with 15 and 20 mg/kg (47.5 ± 2.9 mm2 and 49.4 ± 2.2 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM).. 3. The results suggest that, in the rat, reserpine causes vagal ...
Reserpine - WikipediaReserpine - Wikipedia
Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance. Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered ...
Reserpine - Parkinson Disease - GUWS MedicalReserpine - Parkinson Disease - GUWS Medical
The first demonstration of an animal model for PD was reported by Carlsson in the 1950s using rabbits treated with reserpine. Reserpine is a catecholamine-depleting agent that blocks vesicular storage of monoamines. The akinetic state, resulting from reserpine-induced dopamine depletion in the caudate nucleus and putamen, led Carlsson to speculate that PD was due to loss of dopamine neurotransmission. This speculation was supported by the discovery of reduced striatal dopamine in postmortem brain tissue of PD patients and led to the subsequent use of levodopa (in conjunction with a peripheral dopa-decarboxylase inhibitor) for symptomatic treatment of PD (2,3). Thus, the initial observations derived from an animal model led to an important clinical therapy that still remains the gold standard.. Was this article helpful?. ...
reserpine | Cignareserpine | Cigna
Reserpine lowers blood pressure by slowing down your nervous system. This allows your blood vessels to relax and dilate (widen), which helps your heart beat more slowly and improves blood flow. Reserpine is used to treat hypertension (high blood pressure). Reserpine is also used to treat agitated psychotic conditions...
Subcellular storage and release mode of the novel 18 F-labeled sympathetic nerve PET tracer LMI1195 | EJNMMI Research | Full...Subcellular storage and release mode of the novel 18 F-labeled sympathetic nerve PET tracer LMI1195 | EJNMMI Research | Full...
18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of 18F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced 18F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. After
OPUS Würzburg | SearchOPUS Würzburg | Search
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
OPUS Würzburg | SearchOPUS Würzburg | Search
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
Reserpine, Manufacturer, Supplier, Exporter - Godowell.netReserpine, Manufacturer, Supplier, Exporter - Godowell.net
Buy Reserpine in bulk, where to look for Reserpine Manufacturer, Supplier, Exporter, Send Inquiry to [email protected] for Purchasing Ingredients of Natural extract.
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A series of phenolic hydroxy-2-aminotetralins with either a primary or a tertiary (N,N-di-n-propylated) amino group was investigated on electrically evoked acetylcholine release from striatal slices of reserpinized rats, a dopamine (DA) D2 receptor model. 7-Hydroxy-2-aminotetralin (7-OH-AT) was found to be the most active inhibitor among the primary amines, whereas 5-hydroxy-2-(N,N-dipropylamino)tetralin (5-OH-DPAT) was the most potent compound among the tertiary amines; in the 7-OH series, the activity resided in the (2R)-enantiomers, in contrast to the 5-OH series, where the (2S)-enantiomers represented the effective form. A similar structure-activity pattern was earlier found for the same series of DA agonists at the striatal DA D1 receptor. Differences between the effects of the compounds at the two DA receptor subtypes concerned the N,N-dipropyl substitution which influenced the D2 activity much more pronouncedly, and an added 6-OH group (i.e., a catechol function), which seemed to be of ...
Protective effect of centrally-injected glucagon-like peptide-1 on reserpine-induced gastric mucosal lesions in rat: possible...Protective effect of centrally-injected glucagon-like peptide-1 on reserpine-induced gastric mucosal lesions in rat: possible...
Atıf İçin Kopyala Işbil B., Güleç G. , Ozlük K. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.17, ss.1-6, 2006 (SCI Expanded İndekslerine Giren Dergi) ...
Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats<...Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats<...
TY - JOUR. T1 - Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats. AU - Manara, L.. AU - Garattini, S.. PY - 1967/11. Y1 - 1967/11. N2 - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. AB - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. KW - Tritium ...
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The adrenal glands increase and the thymus and secondary reproductive organs decrease in weight when mice are placed in groups. These changes in weight are related to the size of the population or group and presumably are a reaction to sociopsychological pressures. If such a presumption is correct, reserpine should diminish the differences in the organ weights of grouped and of isolated mice. Grouped and isolated male mice were given 40-50 µg of reserpine (Serpasil, Ciba) per day in their drinking water and the results compared with those from similar numbers of grouped and isolated mice without reserpine. The average number of fights per 10-minute interval per day was 51.4% less in the treated than in the untreated mice for the first 3 days after grouping. Grouped mice, treated and untreated, had heavier adrenals and lighter thymus glands and secondary reproductive organs than their isolated controls. Treatment of grouped mice with reserpine was accompanied by a 5% lower adrenal weight, 28% ...
Reserpine and breast cancer: A longitudinal study of over 2000 hypertensive women<...Reserpine and breast cancer: A longitudinal study of over 2000 hypertensive women<...
TY - JOUR. T1 - Reserpine and breast cancer. T2 - A longitudinal study of over 2000 hypertensive women. AU - Labarthe, D. R.. AU - OFallon, W. M.. PY - 1977/1/1. Y1 - 1977/1/1. UR - http://www.scopus.com/inward/record.url?scp=0017672195&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017672195&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017672195. VL - 106. JO - American Journal of Epidemiology. JF - American Journal of Epidemiology. SN - 0002-9262. IS - 3. ER - ...
50-55-5|Reserpine|Sigma Aldrich|unipres|methyl (1R,15S,17R,18R,19S,20S)-6,18-dim...50-55-5|Reserpine|Sigma Aldrich|unipres|methyl (1R,15S,17R,18R,19S,20S)-6,18-dim...
50-55-5|Reserpine|Sigma Aldrich|unipres|methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-dia...
ATC - C02AA02 - Reserpine - Drugs-about.comATC - C02AA02 - Reserpine - Drugs-about.com
C02AA02 - Reserpine. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs classified in groups at five different levels.
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Rabbits made tolerant to narcotic and lethal doses of l-norepinephrine (3.2 mg/kg intravenous) were infused with dl-norepinephrine-H3 at a rate of 50 µc/kg min-1 for 20 minutes. Concentrations of norepinephrine-H3 in plasma obtained during infusion and for 40 minutes thereafter were similar for the tolerant group, controls and a group treated 24 hours earlier with reserpine (1 mg/kg). Except for reduced concentrations in the heart, uptake of norepinephrine-H3 in organs of tolerant animals was found similar to the controls. In the groups treated with reserpine, norepinephrine-H3 binding was less in all organs but the kidney.. Only about half the normal catechol concentrations were found in hearts of tolerant animals, yet both spleen and kidney were found to contain several times the control amount. Although reserpine markedly diminished the catechol content of the heart, no significant decrease occurred in spleen or kidney.. Mean concentrations of unchanged norepinephrine-H3 in the urines of ...
Reserpine tabletsReserpine tablets
Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
Buy Wodibo Online Capsule Uk | Canadian Pharcharmy OnlineBuy Wodibo Online Capsule Uk | Canadian Pharcharmy Online
Wodibo - Bilateral color changes in the hands after cold exposure or emotional stimuli in patients with underlying connective positive results to intra-arterial reserpine.
S. Afr. j. psyc.- PDF Download - Art. IDS2078-67862014000100007S. Afr. j. psyc.- PDF Download - Art. IDS2078-67862014000100007
ELOFF, I and ESTERHUYSEN, W. Reserpine for the treatment of refractory mania. S. Afr. j. psyc. [online]. 2014, vol.20, n.1, pp.31-32. ISSN 2078-6786.. ...
Can I Take My Medicines With Allegra-D?Can I Take My Medicines With Allegra-D?
As this eMedTV page explains, your healthcare provider needs to be aware of all your other medications before you start Allegra-D. This page gives an explanation of why this is the case and explains what can happen when Allegra-D is taken with reserpine.
Effect of Guanethidine and Bretylium on the Dog Heart-Lung Preparation | Circulation ResearchEffect of Guanethidine and Bretylium on the Dog Heart-Lung Preparation | Circulation Research
Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...
Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia<...Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia<...
TY - JOUR. T1 - Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia. AU - Palfai, Tibor. AU - Walsh, Thomas J.. AU - Albala, Bruce J.. AU - Brown, Oliver M.. PY - 1977/1. Y1 - 1977/1. N2 - In a series of experiments the effects of reserpine, l-Dopa, and d,l,5-hydroxytryptophan (d,l,5-HTP) on retention of a passive avoidance training in mice were investigated. Reserpine (2.5 mg/kg) produced amnesia when given at 120 min before but not at 30 min before or at 0, 10, 30, or 90 min following training. This time-dependent reserpine effect did not appear to be due to either an alteration in footshock sensitivity during training or to the drug producing state-dependent learning. The amnesic effect of reserpine could be blocked when both l-Dopa and d,l,5-HTP were also administered up to 10 min but not at 30 or 90 min following training. The drugs, l-Dopa or d,l,5-HTP, given alone or in higher doses, could not at any time counteract the ...
Reserpine and Chlorthalidone Coupon - Get Instant Reserpine and Chlorthalidone SavingsReserpine and Chlorthalidone Coupon - Get Instant Reserpine and Chlorthalidone Savings
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Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary...Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary...
Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary somatosensory cortex following sciatic nerve section. Article date: 1991/1/1 PubMed ID: 1808975 Journal name: Somatosensory & motor research (ISSN: 0899-0220)
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Amphetamine released 3-H-norepinephrine from rat cerebral cortex tissue which had previously accumulated the 3-H-amine. Destruction of noradrenergic nerve endings by pretreatment of the rats with 6-hydroxydopamine inhibited the accumulation of 3-H-norepinephrine by the tissue and reduced the proportion of the 3-H-amine which was released by amphetamine. Inhibition of storage of 3-H-norepinephrine within nerve endings by pretreatment of the animals with reserpine also reduced accumulation of 3-H-norepinephrine but did not reduce the proportion of the accumulated 3-H-amine which was released by amphetamine. The addition of desipramine (an inhibitor of neuronal uptake) further reduced the accumulation of 3-H-norepinephrine in animals pretreated with reserpine but had no further effect in animals pretreated with 6-hydroxydopamine. A greater proportion of the 3-H-norepinephrine was converted to 3-H-deaminated metabolites in tissues of reserpine-treated animals than in the tissues of control or ...
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Orally administered reserpine is readily absorbed from the GI tract. During this process at least a portion of the drug is metabolized by the intestinal mucosa and then presumably is acted upon by serum esterases. Methylreserpate and trimethoxybenzoic acid are the primary metabolites which result from the hydrolytic cleavage of reserpine. Since most of the blood leaving the GI tract passes through the liver via the portal vein, hepatic metabolism would also be expected to reduce reserpine levels in the blood. The relative contributions of serum esterases versus hepatic metabolism in the biotransformation of reserpine in vivo are not known. However, very little unmetabolized reserpine is eventually eliminated in the urine. In the liver, it is quite likely that both microsomal oxidative and hydrolytic enzymes contribute to the metabolism of reserpine. It seems that microsomal oxidation (such as the demethylation of the 4-methoxy group on the TMBA moiety) must precede hydrolysis since inhibition of ...
chlorothiazide and reserpine - patient information, description, dosage and directions.chlorothiazide and reserpine - patient information, description, dosage and directions.
Description of the drug chlorothiazide and reserpine. - patient information, description, dosage and directions. What is chlorothiazide and reserpine!
Search for HYDROFLUMETHIAZIDE AND RESERPINE Within Specific SitesSearch for HYDROFLUMETHIAZIDE AND RESERPINE Within Specific Sites
Use Google powered SiteComber to search within various sites for HYDROFLUMETHIAZIDE AND RESERPINE. Links to searches for HYDROFLUMETHIAZIDE AND RESERPINE can be found here.
Brain Biogenic Amine Depletion and Mood<...Brain Biogenic Amine Depletion and Mood<...
TY - JOUR. T1 - Brain Biogenic Amine Depletion and Mood. AU - Mendels, Joseph. AU - Frazer, Alan. PY - 1974/4. Y1 - 1974/4. N2 - To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. The behavioral changes associated with reserpine administration were interpreted as being primarily a psychomotor retardation-sedation syndrome, due perhaps to a dopamine deficiency, and would not be an adequate model for clinical depression. In susceptible persons, particularly those with a prior history of depression, this psychomotor retardation-sedation might be sufficient to trigger a depression-like episode. More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that ...
Journal: Applied biochemistry and biotechnology / Publication Year: 2019 / Source: 2019 v.187 no.3 - PubAg Search ResultsJournal: Applied biochemistry and biotechnology / Publication Year: 2019 / Source: 2019 v.187 no.3 - PubAg Search Results
The present study aims to evaluate the antidepressant efficacy of curcumin nanoparticles on rat model of depression induced by reserpine. Rats were divided into control, the rat model of depression induced by daily i.p. injection of reserpine (0.2 mg/kg for 21 days), and the rat model of depression treated daily with the formulated CNPs (20 mg/kg for 7 and 15 days). The behavioral evaluation was a ...
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When investigating potential drug-drug interactions in vitro or in vivo, selective inhibitors are needed that will affect the system investigated without unwanted effects on other components involved in the disposition of the drug. Many P450 inhibitors show substrate dependent effects and IC50 values should be interpreted with caution (Stresser et al., 2000). Quinidine and ketoconazole IC50 values listed in Table 2 are similar to data reported in the literature (Khojasteh et al., 2011). However, absolute P450 IC50 values could vary depending on the substrates and experimental systems used.. Most of the tested P-gp inhibitors showed potent or moderate CYP3A4 as well as moderate CYP2C19 inhibition. However, for three compounds (elacridar, reserpine, and verapamil) the inhibition of P-gp was much more potent than the CYP3A4 inhibition. These should be possible to use experimentally for efficient P-gp inhibition without affecting CYP3A4 at concentrations in the low μM range. Reserpine is a potent ...
Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed RatsAnti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats
Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Then Amitriptyline (5, 10, 20 mg/kg, i.p.) was administered to separate groups of male Wistar rats. All treatments were carried out two hours after colitis induction and continued daily for four days. Dexamethasone (1 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. At day five, animals were euthanized and colonic tissue injuries were assessed macroscopically and pathologically. Myeloperoxidase activity as a marker of neutrophil infiltration was also measured in colonic tissues. Results showed that reserpine (6 mg/kg, i.p.) intensified colitic condition. Compared to control
Hydralazine/hydrochlorothiazide/reserpine Uses, Side Effects & Warnings - Drugs.comHydralazine/hydrochlorothiazide/reserpine Uses, Side Effects & Warnings - Drugs.com
Physician reviewed hydralazine/hydrochlorothiazide/reserpine patient information - includes hydralazine/hydrochlorothiazide/reserpine description, dosage and directions.
Antiparkinsonian actions of a selective 5-HT1A agonist, tandospirone, in rats » Brill OnlineAntiparkinsonian actions of a selective 5-HT1A agonist, tandospirone, in rats » Brill Online
Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
Table 2 - Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain - Volume 15,...Table 2 - Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain - Volume 15,...
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733)
Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates ofStreptococcus pneumoniae |...Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates ofStreptococcus pneumoniae |...
Several efflux proteins are well described in gram-positive bacteria, including Bmr in Bacillus subtilis (1) and NorA in Staphylococcus aureus (15). These can mediate low-level resistance to hydrophilic fluoroquinolones and a variety of unrelated compounds; both are inhibited by reserpine (14, 15). More recently, reserpine was shown to inhibit the level of accumulation of ethidium bromide in an ethidium bromide-selected mutant of S. pneumoniae which showed cross-resistance to fluoroquinolones (5). For this reason we used reserpine to detect mutants resistant to fluoroquinolones by an efflux mechanism.. We showed that reserpine significantly increased the activity of norfloxacin against several norfloxacin-selected mutants. These presumptive efflux mutants also showed increased levels of resistance to ethidium bromide and acriflavine, which agrees with the description by Zeller et al. (20) of the presence of an efflux pump in pneumococci. Ethidium bromide accumulation in strain 1N27, a ...
Reserpine, hydralazine hydrochloride and hydrochlorothiazide / hydralazine hydrochloride; hydrochlorothiazide; reserpine NDA...Reserpine, hydralazine hydrochloride and hydrochlorothiazide / hydralazine hydrochloride; hydrochlorothiazide; reserpine NDA...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Hydralazine/hydrochlorothiazide/reserpine and Alcohol / Food Interactions - Drugs.comHydralazine/hydrochlorothiazide/reserpine and Alcohol / Food Interactions - Drugs.com
Comprehensive alcohol & food interactions for hydralazine / hydrochlorothiazide / reserpine. Includes High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Reserpine / reserpine NDA 080723 international drug patent coverage, generic alternatives and suppliersReserpine / reserpine NDA 080723 international drug patent coverage, generic alternatives and suppliers
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
A Convenient Assay for Estimating the Possible Involvement of Efflux of Fluoroquinolones by Streptococcus pneumoniae...A Convenient Assay for Estimating the Possible Involvement of Efflux of Fluoroquinolones by Streptococcus pneumoniae...
Concluding comments.We validated a new method for assessing the reserpine-mediated effect on fluoroquinolone efflux that is not dependent upon fluorescence. Such a simplified assay for estimating NorA-type efflux is needed because this resistance mechanism is becoming increasingly important, and an agar screening test may not be reliable since reserpine is poorly soluble and present in agar as a suspension, not a solution.. We found the degree of growth inhibition mediated by reserpine was lessened in the new bulkier and/or more hydrophobic agents moxifloxacin (solubility, 2.4 g/100 ml), sparfloxacin (solubility, 0.11 g/100 ml), and trovafloxacin (solubility, 0.002 g/100 ml). However, the growth of organisms in the smaller, more hydrophilic drugs ciprofloxacin (solubility, 3.5 g/100 ml) and levofloxacin (solubility, 2.5 g/100 ml) was strongly inhibited by the presence of reserpine. Of the fluoroquinolones tested, ciprofloxacin has the least bulky C-7 substituent, a piperasine moiety, with ...
Hao - Native Hawaiian Garden (NHG121215)Hao - Native Hawaiian Garden (NHG121215)
Hao is still a relatively common tree in the remnant dry forests of Hawaii making us believe the trees were even more common in ancient times. So, why then are there so few records of the Hawaiians using this tree - surely it was good for something? Hao wood has been found in heiau suggesting it had some unknown religious purpose. But, other than this, reports about its use for construction and firewood are few and conflicting. Unfortunately, we cant go back in time to find the truth but there is one clue as to why Hawaiians may have shunned this native plant. Hao, like its relatives, contains an alkaloid called reserpine, used in other parts of the world to treat high blood pressure and some mental diseases (Degener & Degener 1957). Maybe, the first Hawaiians to use hao (remember, hao is endemic to Hawaii) used it for a very common need, firewood. As the wood burned, the smoke containing the reserpine was likely inhaled by the nearby Hawaiians. This uncontrolled dose of reserpine might have ...
Reserpine, Hydralazine, And Hydrochlorothiazide (Oral Route) Before Using - Mayo ClinicReserpine, Hydralazine, And Hydrochlorothiazide (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Internet Scientific PublicationsInternet Scientific Publications
it means the extract reduced excitability and locomotor as well as exploratory behaviour. The extract thus has a strong sedative property. This is consistent with the fact that one of the main alkaloids found in the plant extract, reserpine, has been found to have some depressive effects on the nervous system. Reserpine causes depletion of the peripheral stores of catecholamines, which accounts for much of the beneficial antihypertensive effect employed over the years 14 . However, depletion of central stores of neurotransmitter amines is responsible for the antipsychotic effects and consequently its adverse side effects such as sedation, depression inability to perform complex tasks and Pseudo-Parkinsonism 15,16 .. The number of faecal boli was also significantly decreased in the test groups when compared to control. This however may not be very informative as there is still some controversy over whether the number of faecal boli and number of urine puddles can be used to accurately assess the ...
Tranquilizers - used, first, anesthetic, blood, body, Tranquilizers Found Useful for Anesthesia, Reserpine, Other OptionsTranquilizers - used, first, anesthetic, blood, body, Tranquilizers Found Useful for Anesthesia, Reserpine, Other Options
Radiotherapy, Retinography, Rh Factor, RU486, Schick Test, Separation of Siamese Twins, Sex Hormones, Skin Grafts, Steroids, Stethoscope, etc…
RausedylRausedyl
... -An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals.
Experimental and clinical aspects of gastrocolic reflexes | SpringerLinkExperimental and clinical aspects of gastrocolic reflexes | SpringerLink
48.. Gillespie JS, Mackenna BR: The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catecholamines and by DOPA. J Physiol 156:17, 1961. ...
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Serpina should be taken inside after meal. The specific dose and duration of treatment are determined individually. In the early stages of hypertension you should be prescribed 0.05-0.1 mg 2-3 times a day. Further, if necessary (but subject to good tolerability), the dose is gradually increased. Maximum daily dose is 1 mg. If within 10-14 days, the hypotensive effect is not achieved, the medication should be overturned. After reaching the effect, the daily dose should be gradually reduced: first, up to 0.5 mg, then up to 0.2 mg and then to 0.1 mg. You should be prescribed the minimum effective dose for maintenance therapy. Treatment is held in courses of 2-3 month up to 4 times a year. In case of neuroses Reserpine is taken in a dose of from 0.25 mg 2-3 times a day to 0.5 mg 3-4 times a day. In case of mental illness on the first day you should be prescribed 0,25-2 mg, then, depending on the clinical situation, the daily dose may be increased to 10-15 mg. the maximum dose for adults: single - 2 ...
Toxicity to tumor cells of combined treatments with diethylamino- rese by S Lehnert"Toxicity to tumor cells of combined treatments with diethylamino- rese" by S Lehnert
Lehnert, S, "Toxicity to tumor cells of combined treatments with diethylamino- reserpine and radiation. Abstr." (1982). Subject Strain Bibliography 1982. 3894 ...
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Is - Of the physiologic effects of the drug, the threshold to electroshock is lowered by reserpine but meprobamate has a blocking action on electroshock.
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The Imodium complete caplets extra mechanical tensile strength fruit brand of loperamide should be taken with food treat or within 1 hour nap after his eating a meal. I die do nt think the vismodegib is increasing quite as made good as loperamide but it is sovereign not bad seamanship and supposedly safer. Loperamide will also potentiate reserpine in fact I once go
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NeurotransmitterNeurotransmitter
List of dopaminergic drugsList of dopaminergic drugs
PharmacognosyPharmacognosy
Eudesmic acidEudesmic acid
NeuromodulationNeuromodulation
Diels-Alder reactionDiels-Alder reaction
SyrosingopineSyrosingopine
TranquilizerTranquilizer
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Indole alkaloidIndole alkaloid
D-COND-CON
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Kathleen MontaguKathleen Montagu
Marthe VogtMarthe Vogt
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ReserpineIproniazidTyramineMethyltyrosinesalpha-MethyltyrosineAdrenergic Uptake InhibitorsNorepinephrineHydroxydopaminesTetrabenazineChlorpromazineMephenterminePargylineCatecholamine Plasma Membrane Transport ProteinsSecologanin Tryptamine AlkaloidsCatecholaminesBiogenic AminesSympathomimeticsNialamideAdrenal MedullaVesicular Monoamine Transport ProteinsPituitary IrradiationBretylium CompoundsVesicular Biogenic Amine Transport ProteinsSerotoninNormetanephrineFenclonineChromaffin GranulesMonoamine Oxidase Inhibitors17-HydroxycorticosteroidsMethyldopaPharmacologyPhenoxybenzamineSynephrineMethysergideDopamineChromaffin SystemClopamideVas DeferensTranylcypromineChlorisondamineTranquilizing AgentsGuanethidineDesipramine5-HydroxytryptophanDextroamphetamineEphedrineMetaraminolEpinephrineDihydroxyphenylalanineAdrenergic AgentsEncyclopedias as TopicBiogenic MonoaminesMonoamine OxidaseAntihypertensive AgentsIndole Alkaloids
Reserpine - WikipediaReserpine - Wikipedia
reserpine | Cignareserpine | Cigna
Modification of leech behavior patterns by reserpine-induced amine depletion | Journal of NeuroscienceModification of leech behavior patterns by reserpine-induced amine depletion | Journal of Neuroscience
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Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte...Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte...
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Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats<...Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats<...
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reserpine | Infopleasereserpine | Infoplease
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reserpine facts, information, pictures | Encyclopedia.com articles about reserpinereserpine facts, information, pictures | Encyclopedia.com articles about reserpine
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Resedrex (Reserpine)Resedrex (Reserpine)
Reserpine discussions (experiences, side effects, dosages, etc...)Reserpine discussions (experiences, side effects, dosages, etc...)
Antileukemic Action of Reserpine | ScienceAntileukemic Action of Reserpine | Science
Reserpine, Hydralazine, And Hydrochlorothiazide (Oral Route) Before Using - Mayo ClinicReserpine, Hydralazine, And Hydrochlorothiazide (Oral Route) Before Using - Mayo Clinic
Effect of Digitalis in Patients Receiving Reserpine | CirculationEffect of Digitalis in Patients Receiving Reserpine | Circulation
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MICROCIRCULATION: EFFECTS OF GUANETHIDINE AND RESERPINE | Journal of Pharmacology and Experimental TherapeuticsMICROCIRCULATION: EFFECTS OF GUANETHIDINE AND RESERPINE | Journal of Pharmacology and Experimental Therapeutics
AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsInformation Science
ReserpineIproniazidTyramineMethyltyrosinesalpha-MethyltyrosineAdrenergic Uptake InhibitorsNorepinephrineHydroxydopaminesTetrabenazineChlorpromazineMephenterminePargylineCatecholamine Plasma Membrane Transport ProteinsSecologanin Tryptamine AlkaloidsCatecholaminesBiogenic AminesSympathomimeticsNialamideAdrenal MedullaVesicular Monoamine Transport ProteinsPituitary IrradiationBretylium CompoundsVesicular Biogenic Amine Transport ProteinsSerotoninNormetanephrineFenclonineChromaffin GranulesMonoamine Oxidase Inhibitors17-HydroxycorticosteroidsMethyldopaPharmacologyPhenoxybenzamineSynephrineMethysergideDopamineChromaffin SystemClopamideVas DeferensTranylcypromineChlorisondamineTranquilizing AgentsGuanethidineDesipramine5-HydroxytryptophanDextroamphetamineEphedrineMetaraminolEpinephrineDihydroxyphenylalanineAdrenergic AgentsEncyclopedias as TopicBiogenic MonoaminesMonoamine OxidaseAntihypertensive AgentsIndole Alkaloids
AntihypertensiveDepletionDopamineGastric mucosalSynthesisHypertensionConcentrationUlcerative colitisVesicularRatsTreatmentInteractionsEnzymeRabbitsPeripheralDepressionCompoundEffectsAdministrationDrugsBloodTimeJournalBreastPharmacologyEffects of reserpineDosesRestored following reserpinePregnant while taking reEffect of reserpineMonoaminesLowers blood pressureTake reserpineYohimbine0.25 mgAcuteIndole alkaloidOral dyskinesiaPeenSerpalanAlkaloidsOxidative stressDoseSlowlySandrilSchizophreniaMedicationIsolated in 1952Anti-adrenergicAlkaloid isolatedAntihypertensive agentsCatecholaminesHydralazineIncreasesChlorothiazideSymptomsBehavioralTartrazineHigh blood prOrallyMotor impairmentsSearchGalactorrheaChlorthalidoneBrainRodentsJacobsen
Antihypertensive5
Depletion2
  • Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). (wikipedia.org)
  • The akinetic state, resulting from reserpine-induced dopamine depletion in the caudate nucleus and putamen, led Carlsson to speculate that PD was due to loss of dopamine neurotransmission. (guwsmedical.info)
Dopamine1
Gastric mucosal3
  • 1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm 2 , mean ± SEM). (portlandpress.com)
  • 3. The results suggest that, in the rat, reserpine causes vagal α-adrenoceptor stimulation producing gastric mucosal vasoconstriction and injury. (portlandpress.com)
  • Protective effect of centrally-injected glucagon-like peptide-1 on reserpine-induced gastric mucosal lesions in rat: possible mechanisms. (acibadem.edu.tr)
Synthesis1
Hypertension3
Concentration2
  • After 2 h of 18 F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. (springeropen.com)
  • Both high concentration KCl and reserpine enhanced 18 F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. (springeropen.com)
Ulcerative colitis1
  • You should not use reserpine if you have a stomach ulcer, ulcerative colitis, a history of depression or suicidal thoughts, or if you are being treated with electroconvulsive therapy. (cigna.com)
Vesicular2
Rats3
  • Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5-15 mg/kg) did not influence these effects of reserpine, but vagotomy protected the rats against them. (portlandpress.com)
  • Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. (elsevier.com)
  • Manara, L & Garattini, S 1967, ' Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats ', European Journal of Pharmacology , vol. 2, no. 2, pp. 139-141. (elsevier.com)
Treatment2
  • Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), which had been known as Sarpagandha and had been used for centuries in India for the treatment of insanity, as well as fever and snakebites - Mahatma Gandhi used it as a tranquilizer. (wikipedia.org)
  • Similar tracer kinetics after KCl or reserpine treatment were also observed using 131 I-MIBG. (springeropen.com)
Interactions1
Enzyme1
  • Tryptophan is the starting material in the biosynthetic pathway of reserpine, and is converted to tryptamine by tryptophan decarboxylase enzyme. (wikipedia.org)
Rabbits1
  • The first demonstration of an animal model for PD was reported by Carlsson in the 1950s using rabbits treated with reserpine. (guwsmedical.info)
Peripheral1
  • Moreover, reserpine has a peripheral action in many parts of the body, resulting in a preponderance of the effects of the cholinergic part of the autonomous nervous system on the GI tract, smooth muscles, blood vessels, etc. (wikipedia.org)
Depression3
  • The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant. (wikipedia.org)
  • Reserpine was also highly influential in promoting the thought of a biogenic amine hypothesis of depression - see Everett & Tolman, 1959. (wikipedia.org)
  • Some people taking reserpine have developed depression. (cigna.com)
Compound1
  • Notably, reserpine was the first compound shown to be an effective antidepressant in a randomized placebo-controlled trial. (wikipedia.org)
Effects1
Administration1
  • In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration. (elsevier.com)
Drugs1
Blood1
Time1
  • If you need surgery, tell the surgeon ahead of time that you are using reserpine. (cigna.com)
Journal1
  • Labarthe, DR & O'Fallon, WM 1977, ' Reserpine and breast cancer: A longitudinal study of over 2000 hypertensive women ', American Journal of Epidemiology , vol. 106, no. 3. (northwestern.edu)
Breast2
Pharmacology1
  • U'Prichard, DC & Snyder, SH 1978, ' 3H-catecholamine binding to α-receptors in rat brain: Enhancement by reserpine ', European Journal of Pharmacology , vol. 51, no. 2, pp. 145-155. (elsevier.com)
Effects of reserpine3
Doses6
Restored following reserpine1
Pregnant while taking re2
  • If you become pregnant while taking reserpine, call your doctor. (medlineplus.gov)
  • Tell your doctor if you are pregnant or plan to become pregnant while taking reserpine. (cigna.com)
Effect of reserpine1
  • Finally, cotransfer experiments indicated that the effect of reserpine on the transfer of CS was not due to activation of suppressor cells. (rupress.org)
Monoamines5
  • Kalueff, A. V. Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish. (alfa.com)
  • Reserpine precludes the storage of monoamines through the blockage of the synaptic vesicles transporters [ 1 ]. (omicsonline.org)
  • Besides its classical mechanism of action (i.e. blockage of the vesicular transport of monoamines), there is clear evidence that reserpine also causes an increase in cellular oxidative stress, possibly potentiated by the rise in the levels of dopamine in the cytoplasm, which undergoes oxidative metabolism [ 10 ]. (omicsonline.org)
  • Reserpine acts at the membrane of intraneuronal granules which store monoamines (NA, 5-HT, DA) and irreversibly inhibits the active amine transporters so the monoamines are gradually depleted and degraded by MAO. (medicineport.com)
  • Reserpine is a catecholamine-depleting agent that blocks vesicular storage of monoamines. (guwsmedical.info)
Lowers blood pressure2
Take reserpine4
Yohimbine4
  • A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line. (aspetjournals.org)
  • We previously showed that there is a structure-function relationship among reserpine and yohimbine analogues in their ability to inhibit the function of P-glycoprotein (P-gp) and reverse multidrug resistance (MDR). (aspetjournals.org)
  • Because some P-gp inhibitors (e.g., verapamil and nifedipine) can increase mdr1 and P-gp expression in human colon carcinoma cell lines, we used our reserpine/yohimbine analogues to determine whether there was a structural requirement for this induction. (aspetjournals.org)
  • The reserpine/yohimbine analogues rescinnamine, trimethoxybenzoylyohimbine, and LY191401 (compound G), all of which contain the three structural elements used to describe the MDR pharmacophore, also increased both mdr1 and P-gp expression significantly. (aspetjournals.org)
0.25 mg3
  • The daily dose of reserpine in antihypertensive treatment is as low as 0.1 to 0.25 mg. (wikipedia.org)
  • Reserpine (0.25 mg/kg s.c. per day for 3 weeks) causes 25 and 46% increases in the numbers of (±)- 3 H-epinephrine and 3 H-WB-4101 α-receptor binding sites respectively, and a 51% increase in the number of 3 H-dihydroalprenolol β-receptor sites, in rat forebrain. (elsevier.com)
  • Reserpine (0.25 mg/kg s.c. per day for 3 weeks) causes 25 and 46{\%} increases in the numbers of (±)-3H-epinephrine and 3H-WB-4101 α-receptor binding sites respectively, and a 51{\%} increase in the number of 3H-dihydroalprenolol β-receptor sites, in rat forebrain. (elsevier.com)
Acute5
Indole alkaloid3
  • Reserpine (Lannett's Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms. (godowell.net)
  • Reserpine is an indole alkaloid isolated in 1952 from the extract of Rauwolfia sepentina or 'Indian snake root', a popular plant in traditional Indian medicine used as a sedative and antipyretic, and reportedly taken by Mahatma Gandhi himself. (brsmblog.com)
  • Reserpine, an indole alkaloid and antipsychotic drug, is used to control high blood pressure and to relieve psychotic symptoms. (spectrumchemical.com)
Oral dyskinesia1
  • The finding that reserpine-induced oral dyskinesia persisted despite repletion of dopamine in the caudate-putamen suggests that the persistent neuropathological change underlying this behavior occurs in a neural pathway other than the dopaminergic nigrostriatal pathway. (elsevier.com)
Peen1
Serpalan1
  • Serpalan etc. (reserpine) is an anti-adrenergic medication used to treat high blood pressure (hypotension). (rightpet.com)
Alkaloids1
Oxidative stress4
  • The animals treated with reserpine showed moderate alterations at hind limb skeletal muscles level and had difficulty in moving, together with significant morphological and ultrastructural alterations and expression of inflammatory and oxidative stress markers in the gastrocnemius muscle. (mdpi.com)
  • In the biochemical level, the ability of astaxanthin to mitigate reserpine-induced oxidative stress was evaluated by the measurement of malondialdehyde (MDA) and nitric oxide (NO) in brain, liver and plasma samples. (eurekaselect.com)
  • Conclusion: This study suggests that astaxanthin reduces reserpine-induced oxidative stress and therefore might be effective in treating oxidative stress associated depression. (eurekaselect.com)
  • in order to investigate a possible role of nigrostriatal dopaminergic supersensitivity and of oxidative stress in aging- and reserpine-induced OD, the stereotyped behavior induced by dopaminergic agonists, a functional index of dopaminergic striatal activity, as well as the striatal antioxidant enzymes glutathione peroxidase and catalase were assessed. (unifesp.br)
Dose2
  • The increase in enzyme activity of rat ganglia and adrenals was dose-dependent up to 5 mg/kg and persisted for at least four days after reserpine was given. (aspetjournals.org)
  • You may require a lower dose or special monitoring during therapy with chlorothiazide and reserpine if you have any of the conditions listed above. (drugster.info)
Slowly1
  • What is the most important information I should know about chlorothiazide and reserpine?Stand up slowly from a sitting or lying position. (drugster.info)
Sandril1
Schizophrenia1
Medication3
  • Reserpine may also be used for purposes not listed in this medication guide. (cigna.com)
  • Reserpine used in conjunction with other psychotropic medication may be considered in the treatment of refractory mania, but controlled trials are necessary to support our finding more generally. (scielo.org.za)
  • The Medication Coupons.com Drug Savings card saves you up to 85% or more on Reserpine and Chlorthalidone . (medicationcoupons.com)
Isolated in 19521
  • Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), which had been known as Sarpagandha and had been used for centuries in India for the treatment of insanity, as well as fever and snakebites - Mahatma Gandhi used it as a tranquilizer. (wikipedia.org)
Anti-adrenergic1
Alkaloid isolated1
  • reserpine rÄ•sûr´pÄ“n [ key ] , alkaloid isolated from the root of the snakeroot plant ( Rauwolfia serpentina ), a small evergreen climbing shrub of the dogbane family native to the Indian subcontinent. (infoplease.com)
Antihypertensive agents1
Catecholamines1
Hydralazine1
  • Although there is no specific information comparing use of reserpine, hydralazine, and hydrochlorothiazide combination in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (mayoclinic.org)
Increases2
  • Since reserpine increases gastrointestinal motility and secretion, it should be used cautiously in patients with a history of peptic ulcer , ulcerative colitis , or gallstones ( biliary colic may be precipitated). (wikidoc.org)
  • After the administration of reserpine, the in vitro tyrosine hydroxylase activity increases in rat, guinea-pig, mouse and rabbit adrenal gland, in rat superior cervical ganglia and in rabbit brainstem. (aspetjournals.org)
Chlorothiazide14
Symptoms3
  • Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (medlineplus.gov)
  • His manic symptoms improved markedly with the addition of reserpine to the treatment regimen. (scielo.org.za)
  • Reserpine is a kind of drug that is being used for the control of high blood pressure and for the relief of psychotic symptoms. (eanswers.net)
Behavioral2
  • The results show a preventive role of alpha-tocopherol on behavioral alterations induced by repeated reserpine treatment. (omicsonline.org)
  • Method: On the behavioral level, antidepressant property of astaxanthin (50 mg/kg, orally) on reserpine (2 mg/kg, subcutaneously) induced depressed mice was evaluated by forced swim test (FST) and tail suspension test (TST). (eurekaselect.com)
Tartrazine1
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (medlineplus.gov)
High blood pr4
  • Reserpine is used to treat high blood pressure. (medlineplus.gov)
  • If you suddenly stop taking reserpine you may develop high blood pressure and experience unwanted side effects. (medlineplus.gov)
  • Rauvolfia (family Apocynaceae ) A genus of shrubs or small trees, some species of which, especially R. serpentina , produce the alkaloid reserpine, used to counteract high blood pressure. (encyclopedia.com)
  • Together, chlorthalidone and reserpine are used to lower high blood pressure. (drugster.info)
Orally1
  • Orally administered reserpine is readily absorbed from the GI tract. (aspetjournals.org)
Motor impairments1
Search1
Galactorrhea2
  • There is a report of galactorrhea associated with reserpine. (drugs.com)
  • Reserpine has reportedly caused galactorrhea and has been used to increase breastmilk production, although it is obsolete for this use. (anikamd.com)
Chlorthalidone2
Brain1
  • In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration. (elsevier.com)
Rodents1
  • Because an important loss of dopaminergic neurons is the core feature of Parkinson´s disease (PD) [ 2 ], reserpine administration to rodents is a valid approach to study this disease in animal models [ 3 - 5 ]. (omicsonline.org)
Jacobsen1
  • Jacobsen, E. N. Enantioselective Total Synthesis of (+)-Reserpine. (alfa.com)
Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte...
Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte... (jem.rupress.org)
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Reserpine, Manufacturer, Supplier, Exporter - Godowell.net
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Austedo (Deutetrabenazine Tablets): Side Effects, Interactions, Warning, Dosage & Uses
Austedo (Deutetrabenazine Tablets): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
DailyMed - PROPRANOLOL HYDROCHLORIDE capsule, extended release
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Anti- Hypertensives - ICD Codes
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PROPRANOLOL HYDROCHLORIDE INJECTION, USP
PROPRANOLOL HYDROCHLORIDE INJECTION, USP (dailymed.nlm.nih.gov)
Frontiers | Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer's Disease: Present Status and Future Opportunities...
Frontiers | Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer's Disease: Present Status and Future Opportunities... (frontiersin.org)
Reserpine - Substance Information - ECHA
Reserpine - Substance Information - ECHA (echa.europa.eu)
Top 10 Plants That Led To Useful And Lifesaving Drugs - Listverse
Top 10 Plants That Led To Useful And Lifesaving Drugs - Listverse (listverse.com)
50-55-5 - Reserpine, 99% - L03506 - Alfa Aesar
50-55-5 - Reserpine, 99% - L03506 - Alfa Aesar (alfa.com)
Reserpine for the Treatment of Cocaine Dependence - 1 - Full Text View - ClinicalTrials.gov
Reserpine for the Treatment of Cocaine Dependence - 1 - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
RESERPINE IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Annals of Internal Medicine | American College of Physicians
RESERPINE IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Annals of Internal Medicine | American College of Physicians (annals.org)
Modification of leech behavior patterns by reserpine-induced amine depletion | Journal of Neuroscience
Modification of leech behavior patterns by reserpine-induced amine depletion | Journal of Neuroscience (jneurosci.org)
Insulin Human Inhalation: MedlinePlus Drug Information
Insulin Human Inhalation: MedlinePlus Drug Information (medlineplus.gov)
Known and Probable Human Carcinogens
Known and Probable Human Carcinogens (cancer.org)
Catecholamine blood test: MedlinePlus Medical Encyclopedia
Catecholamine blood test: MedlinePlus Medical Encyclopedia (medlineplus.gov)
St. John's Wort: Drug-Supplement Interactions
St. John's Wort: Drug-Supplement Interactions (familydoctor.org)