An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Dopamines with a hydroxy group substituted in one or more positions.
A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
A monoamine oxidase inhibitor with antihypertensive properties.
A group of membrane transport proteins that transport biogenic amine derivatives of catechol across the PLASMA MEMBRANE. Catecholamine plasma membrane transporter proteins regulate neural transmission as well as catecholamine metabolism and recycling.
Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
An MAO inhibitor that is used as an antidepressive agent.
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
A family of vesicular amine transporter proteins that catalyze the transport and storage of CATECHOLAMINES and indolamines into SECRETORY VESICLES.
Radiation therapy used to treat the PITUITARY GLAND.
Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
A sulfamoylbenzamide piperidine. It is considered a thiazide-like diuretic.
The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart. (1/855)

[11C]Phenylephrine (PHEN) is a radiolabeled analogue of norepinephrine that is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and taken up into storage vesicles localized within the nerve varicosities by the vesicular monoamine transporter. PHEN is structurally related to two previously developed sympathetic nerve markers: [11C]-meta-hydroxyephedrine and [11C]epinephrine. To better characterize the neuronal handling of PHEN, particularly its sensitivity to neuronal monoamine oxidase (MAO) activity, kinetic studies in an isolated working rat heart system were performed. METHODS: Radiotracer was administered to the isolated working heart as a 10-min constant infusion followed by a 110-min washout period. Two distinctly different approaches were used to assess the sensitivity of the kinetics of PHEN to MAO activity. In the first approach, oxidation of PHEN by MAO was inhibited at the enzymatic level with the MAO inhibitor pargyline. In the second approach, the two hydrogen atoms on the a-carbon of the side chain of PHEN were replaced with deuterium atoms ([11C](-)-alpha-alpha-dideutero-phenylephrine [D2-PHEN]) to inhibit MAO activity at the tracer level. The importance of vesicular uptake on the kinetics of PHEN and D2-PHEN was assessed by inhibiting vesicular monoamine transporter-mediated storage into vesicles with reserpine. RESULTS: Under control conditions, PHEN initially accumulated into the heart at a rate of 0.72+/-0.15 mL/min/g wet. Inhibition of MAO activity with either pargyline or di-deuterium substitution did not significantly alter this rate. However, MAO inhibition did significantly slow the clearance of radioactivity from the heart during the washout phase of the study. Blocking vesicular uptake with reserpine reduced the initial uptake rates of PHEN and D2-PHEN, as well as greatly accelerated the clearance of radioactivity from the heart during washout. CONCLUSION: These studies indicate that PHEN kinetics are sensitive to neuronal MAO activity. Under normal conditions, efficient vesicular storage of PHEN serves to protect the tracer from rapid metabolism by neuronal MAO. However, it is likely that leakage of PHEN from the storage vesicles and subsequent metabolism by MAO lead to an appreciable clearance of radioactivity from the heart.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/855)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

A possible mode of cardiovascular actions of dopamine in dogs. (3/855)

A possible mode of cardiovascular actions of dopamine was studied using ephedrine. In the dog pretreated with repeated administrations of ephedrine (total dose, 40 or 80 mg/kg, i.v.) or with combined administrations of ephedrine (total dose, 90 mg/kg, s.c. and i.v.) and reserpine (2 mg/kg, s.c., 24 hr previously), pressor responses to dopamine were eliminated and reversed to depressor responses whereas depressor responses to dopamine were potentiated. Positive chronotropic effects of dopamine were almost eliminated. Pressor and positive chronotropic effects of tyramine were almost abolished. Sympathomimetic effect of noradrenaline and adrenaline were potentiated while those of isoprenaline were inhibited. In the heart-lung preparation of ephedrine-treated dogs (total dose, 40 mg/kg, i.v.), cardiac stimulating effects of dopamine and tyramine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent. In the open-chest dogs, after pretreatment of cocaine (4 mg/kg, i.v.), pressor, positive inotropic and chronotropic effects of noradrenaline were potentiated, whilst those of tyramine were inhibited. Those of dopamine were not visibly altered, but depressor, negative chronotropic and inotropic effects of dopamine appeared at small doses. In the ephedrine-pretreated dogs, these sympathomimetic effects of dopamine and tyramine after cocaine were strongly depressed and those of noradrenaline were inhibited to a certain degree. The results obtained with ephedrine suggest that dopamine differs from other catecholamines and tyramine in the mode of cardiovascular actions.  (+info)

Pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2-(3H)-furylidene]-1,3-cyclopentanedione (oudenone). (4/855)

The pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2(3H)-furylidene]-1,3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10--40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized rats. In unanesthetized spontaneously hypertensive rats (SHR), oudenone (5--200 mg/kg p.o.) caused a dose-related decrease in the systolic blood pressure. The initial pressor effect was diminished by pretreatments with phentolamine, guanethidine, hexamethonium and was abolished in the pithed rats. In addition, intracisternal administrations of oudenone (100--600 mug/kg) showed a marked increase in blood pressure in the anesthetized rats, suggesting that the pressor effect may be due to centrally mediated actions. Oudenone, given intra-arterially into the femoral artery (400--800 mug/kg), caused a long-lasting vasodilation in anesthetized dogs. At a relatively high dose (40 mg/kg i.v.), oudenone antagonized all pressor responses to autonomic agents and central vagus nerve stimulation in anesthetized rats and dogs, however, oudenone showed no anti-cholinergic,-histaminergic, beta-adrenergic and adrenergic neuron blocking properties.  (+info)

The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. (5/855)

The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether beta-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that beta3-adrenergic receptors and classical beta1/beta2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue.  (+info)

The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (6/855)

In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested.  (+info)

Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. (7/855)

Methamphetamine (METH) is a powerful psychostimulant that is increasingly abused worldwide. Although it is commonly accepted that the dopaminergic system and oxidation of dopamine (DA) play pivotal roles in the neurotoxicity produced by this phenylethylamine, the primary source of DA responsible for this effect has remained elusive. In this study, we used mice heterozygous for vesicular monoamine transporter 2 (VMAT2 +/- mice) to determine whether impaired vesicular function alters the effects of METH. METH-induced dopaminergic neurotoxicity was increased in striatum of VMAT2 +/- mice compared with wild-type mice as revealed by a more consistent DA and metabolite depletion and a greater decrease in dopamine transporter expression. Interestingly, increased METH neurotoxicity in VMAT2 +/- mice was accompanied by less pronounced increase in extracellular DA and indices of free radical formation compared with wild-type mice. These results indicate that disruption of vesicular monoamine transport potentiates METH-induced neurotoxicity in vivo and point, albeit indirectly, to a greater contribution of intraneuronal DA redistribution rather than extraneuronal overflow on mediating this effect.  (+info)

Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine. (8/855)

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.  (+info)

A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. Subsequently, amine levels recovered slowly, but remained depressed 6 months after reserpine injection. Following reserpine treatment, glyoxylic acid-induced fluorescence or neutral red staining closely mirrored the HPLC-determined time course of amine depletion and recovery. Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. The threshold concentration of reserpine necessary to produce amine depletion was approximately 1 microM. We found that reserpine treatment eliminated biting behavior within 4 d following injection. Biting behavior ...
The treatment of hypertension with reserpine is described. When used alone it produced adequatefalls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its parasympathetic side effects. The combination of reserpine and pentapyrrolidinium is regarded as the best therapeutic regime for severe hypertension. Some mild cases of hypertension may be managed with reserpine alone.. ...
Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocker reserpine was previously shown to increase enkephalin levels several-fold. To explore the biochemical mechanism of this effect, we examined the effect of reserpine treatment on the activities of three different peptide precursor processing enzymes: carboxypeptidase E (CPE) and the prohormone convertases (PCs) PC1/3 and PC2. Reserpine treatment increased both CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered for any enzyme. Further analysis showed that the increase in CPE activity was due to an elevated Vmax, with no change in the Km for substrate hydrolysis or the levels of CPE mRNA. Reserpine activation of endogenous processing enzymes was also observed in extracts prepared from PC12 cells stably expressing PC1/3 or PC2. In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3 and PC2, with dopamine quinone the most ...
Serotonin is known as one of the most important neurotransmitters. This amine structured neurotransmitter Ievel is influenced in migraine. Plasma serotonin Ievel is essentially decreased during migraine atacks. It is known that reserpine has an amine-releasing effect. In this study, migraine-Iike episodes were constituted in thirty-three guinea pigs by intraperitoneal reserpine administration. Then the auditory brainstem evoked potentials were recorded. All absolute and interpeak lalency values were initially increased at the second hour of reserpine administration and reached to the maximum values at third hour, and then gradually decreased up to twelfth hour. This result mainly reflects the brainstem involvement in migraine-Iike attack induced by reserpine administration. Subsequent Iatency parameters which are close to baseline values may be attributed to the fact that these changes are temporary and follow the variations in the serotonin Ievels. . ...
It has been suggested that reserpine blocks expression of delayed hypersensitivity (DH) by depleting tissue mast cells of serotonin (5-HT), thereby preventing a T cell-dependent release of mast cell 5-HT necessary to localize and to amplify the DH response. However, reserpine blocks expression of DH in mast cell-deficient mice. We therefore decided to reevaluate the mechanism by which reserpine abrogates expression of cellular immunity, and investigated whether the drug might interfere with T cell activity in vitro or in vivo. At concentrations as low as 4 microM, reserpine profoundly suppressed baseline or antigen-augmented levels of [3H]thymidine incorporation by immune lymph node cells obtained from mice sensitized to the contactant oxazolone [I-LNC(Ox)]. This effect was observed both with I-LNC derived from normal mice and with I-LNC derived from congenitally mast cell-deficient W/Wv mice, cell preparations that lacked detectable mast cells, histamine, and 5-HT. Furthermore, treatment of ...
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1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm2, mean ± SEM). Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5-15 mg/kg) did not influence these effects of reserpine, but vagotomy protected the rats against them. The α-adrenoceptor-blocking drugs phenoxybenzamine and phentolamine at 5 mg/kg were protective against injury. However, a 10 mg/kg dose of either blocker was more effective (2.2 ± 0.5 mm2 and 3 ± 0.8 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM, P ,0.01) and a dose of 15 mg/kg afforded complete protection.. 2. Methysergide, a 5-hydroxytryptamine receptor antagonist, produced a dose-dependent increase in the reserpine-induced injury; a significant (P ,0.05) increase was noted with 15 and 20 mg/kg (47.5 ± 2.9 mm2 and 49.4 ± 2.2 mm2, respectively, versus 38.8 ± 2.1 mm2, mean ± SEM).. 3. The results suggest that, in the rat, reserpine causes vagal ...
Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance. Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered ...
The first demonstration of an animal model for PD was reported by Carlsson in the 1950s using rabbits treated with reserpine. Reserpine is a catecholamine-depleting agent that blocks vesicular storage of monoamines. The akinetic state, resulting from reserpine-induced dopamine depletion in the caudate nucleus and putamen, led Carlsson to speculate that PD was due to loss of dopamine neurotransmission. This speculation was supported by the discovery of reduced striatal dopamine in postmortem brain tissue of PD patients and led to the subsequent use of levodopa (in conjunction with a peripheral dopa-decarboxylase inhibitor) for symptomatic treatment of PD (2,3). Thus, the initial observations derived from an animal model led to an important clinical therapy that still remains the gold standard.. Was this article helpful?. ...
Reserpine lowers blood pressure by slowing down your nervous system. This allows your blood vessels to relax and dilate (widen), which helps your heart beat more slowly and improves blood flow. Reserpine is used to treat hypertension (high blood pressure). Reserpine is also used to treat agitated psychotic conditions...
18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of 18F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced 18F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. After
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
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This study describes the effects of brain-stem cholinergic laterodorsal tegmental (LDT) stimulation on the synaptic responsiveness of anterior thalamic (AT) neurons. A sample of AT cells, physiologically identified by their short-latency (less than 6.5 msec) response to mammillary body (MB) stimulation, was recorded in unanesthetized, chronically implanted cats and in urethane-anesthetized cats. In chronic experiments, LDT stimulation evoked a short-latency (10-20 msec) excitation in most AT cells. Moreover, brief LDT trains (3 shocks at 300 Hz, every 3 sec) enhanced the responsiveness of AT cells to both MB (orthodromic) and cortical (ortho- and antidromic) stimuli. This effect did not vary as a function of the interval between LDT conditioning and MB or cortical testing shocks, but as a function of the number of trials. The effects of LDT stimuli resisted reserpine treatment (0.75 mg/kg), suggesting that they were not dependent on the coactivation of monoaminergic fibers. Finally, LDT trains ...
A series of phenolic hydroxy-2-aminotetralins with either a primary or a tertiary (N,N-di-n-propylated) amino group was investigated on electrically evoked acetylcholine release from striatal slices of reserpinized rats, a dopamine (DA) D2 receptor model. 7-Hydroxy-2-aminotetralin (7-OH-AT) was found to be the most active inhibitor among the primary amines, whereas 5-hydroxy-2-(N,N-dipropylamino)tetralin (5-OH-DPAT) was the most potent compound among the tertiary amines; in the 7-OH series, the activity resided in the (2R)-enantiomers, in contrast to the 5-OH series, where the (2S)-enantiomers represented the effective form. A similar structure-activity pattern was earlier found for the same series of DA agonists at the striatal DA D1 receptor. Differences between the effects of the compounds at the two DA receptor subtypes concerned the N,N-dipropyl substitution which influenced the D2 activity much more pronouncedly, and an added 6-OH group (i.e., a catechol function), which seemed to be of ...
Atıf İçin Kopyala Işbil B., Güleç G. , Ozlük K. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.17, ss.1-6, 2006 (SCI Expanded İndekslerine Giren Dergi) ...
TY - JOUR. T1 - Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats. AU - Manara, L.. AU - Garattini, S.. PY - 1967/11. Y1 - 1967/11. N2 - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. AB - Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration.. KW - Tritium ...
The adrenal glands increase and the thymus and secondary reproductive organs decrease in weight when mice are placed in groups. These changes in weight are related to the size of the population or group and presumably are a reaction to sociopsychological pressures. If such a presumption is correct, reserpine should diminish the differences in the organ weights of grouped and of isolated mice. Grouped and isolated male mice were given 40-50 µg of reserpine (Serpasil, Ciba) per day in their drinking water and the results compared with those from similar numbers of grouped and isolated mice without reserpine. The average number of fights per 10-minute interval per day was 51.4% less in the treated than in the untreated mice for the first 3 days after grouping. Grouped mice, treated and untreated, had heavier adrenals and lighter thymus glands and secondary reproductive organs than their isolated controls. Treatment of grouped mice with reserpine was accompanied by a 5% lower adrenal weight, 28% ...
TY - JOUR. T1 - Reserpine and breast cancer. T2 - A longitudinal study of over 2000 hypertensive women. AU - Labarthe, D. R.. AU - OFallon, W. M.. PY - 1977/1/1. Y1 - 1977/1/1. UR - http://www.scopus.com/inward/record.url?scp=0017672195&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017672195&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017672195. VL - 106. JO - American Journal of Epidemiology. JF - American Journal of Epidemiology. SN - 0002-9262. IS - 3. ER - ...
50-55-5|Reserpine|Sigma Aldrich|unipres|methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-dia...
C02AA02 - Reserpine. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs classified in groups at five different levels.
Rabbits made tolerant to narcotic and lethal doses of l-norepinephrine (3.2 mg/kg intravenous) were infused with dl-norepinephrine-H3 at a rate of 50 µc/kg min-1 for 20 minutes. Concentrations of norepinephrine-H3 in plasma obtained during infusion and for 40 minutes thereafter were similar for the tolerant group, controls and a group treated 24 hours earlier with reserpine (1 mg/kg). Except for reduced concentrations in the heart, uptake of norepinephrine-H3 in organs of tolerant animals was found similar to the controls. In the groups treated with reserpine, norepinephrine-H3 binding was less in all organs but the kidney.. Only about half the normal catechol concentrations were found in hearts of tolerant animals, yet both spleen and kidney were found to contain several times the control amount. Although reserpine markedly diminished the catechol content of the heart, no significant decrease occurred in spleen or kidney.. Mean concentrations of unchanged norepinephrine-H3 in the urines of ...
Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
This MassBank Record with Accession PB005762 contains the MS2 mass spectrum of Reserpine with the InChIKey QEVHRUUCFGRFIF-MDEJGZGSSA-N.
Wodibo - Bilateral color changes in the hands after cold exposure or emotional stimuli in patients with underlying connective positive results to intra-arterial reserpine.
ELOFF, I and ESTERHUYSEN, W. Reserpine for the treatment of refractory mania. S. Afr. j. psyc. [online]. 2014, vol.20, n.1, pp.31-32. ISSN 2078-6786.. ...
As this eMedTV page explains, your healthcare provider needs to be aware of all your other medications before you start Allegra-D. This page gives an explanation of why this is the case and explains what can happen when Allegra-D is taken with reserpine.
Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...
TY - JOUR. T1 - Effects of l-dihydroxyphenylalanine (l-Dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia. AU - Palfai, Tibor. AU - Walsh, Thomas J.. AU - Albala, Bruce J.. AU - Brown, Oliver M.. PY - 1977/1. Y1 - 1977/1. N2 - In a series of experiments the effects of reserpine, l-Dopa, and d,l,5-hydroxytryptophan (d,l,5-HTP) on retention of a passive avoidance training in mice were investigated. Reserpine (2.5 mg/kg) produced amnesia when given at 120 min before but not at 30 min before or at 0, 10, 30, or 90 min following training. This time-dependent reserpine effect did not appear to be due to either an alteration in footshock sensitivity during training or to the drug producing state-dependent learning. The amnesic effect of reserpine could be blocked when both l-Dopa and d,l,5-HTP were also administered up to 10 min but not at 30 or 90 min following training. The drugs, l-Dopa or d,l,5-HTP, given alone or in higher doses, could not at any time counteract the ...
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Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary somatosensory cortex following sciatic nerve section. Article date: 1991/1/1 PubMed ID: 1808975 Journal name: Somatosensory & motor research (ISSN: 0899-0220)
hypertension and sexual function in men and outlines a management strategy for clinicians that attempts. drugs such as guanethidine and reserpine.16 Due to.. Coronary Artery Disease and ED Epidemiological studies show that nearly 75% of men with coronary artery disease also have ED.Vascular and cavernosal smooth muscle dysfunction appear to share the same risk factors, and ED may be an early signal of impending cardiovascular problems. (Heart 2003;89 251-3 J Urol 2003; 170S46-50). The risk factors for coronary heart disease and ED are.. Superdrug is expanding its erectile dysfunction portfolio after demand for services increased by 13% between May and June, it has announced.. 12 medications found for severe psychosis Sorted by User Reviews Drug Name Indication Type User Reviews reserpine 0.25 mg tablet On Label RX 6 reviews serpasil tablet On Label RX 1 Reviews.. Reserpine (Serpasil) Spironolactone (aldactone) triamterene (maxzide) Verapamil (Calan) Thiazides are the most common cause of ...
Amphetamine released 3-H-norepinephrine from rat cerebral cortex tissue which had previously accumulated the 3-H-amine. Destruction of noradrenergic nerve endings by pretreatment of the rats with 6-hydroxydopamine inhibited the accumulation of 3-H-norepinephrine by the tissue and reduced the proportion of the 3-H-amine which was released by amphetamine. Inhibition of storage of 3-H-norepinephrine within nerve endings by pretreatment of the animals with reserpine also reduced accumulation of 3-H-norepinephrine but did not reduce the proportion of the accumulated 3-H-amine which was released by amphetamine. The addition of desipramine (an inhibitor of neuronal uptake) further reduced the accumulation of 3-H-norepinephrine in animals pretreated with reserpine but had no further effect in animals pretreated with 6-hydroxydopamine. A greater proportion of the 3-H-norepinephrine was converted to 3-H-deaminated metabolites in tissues of reserpine-treated animals than in the tissues of control or ...
Orally administered reserpine is readily absorbed from the GI tract. During this process at least a portion of the drug is metabolized by the intestinal mucosa and then presumably is acted upon by serum esterases. Methylreserpate and trimethoxybenzoic acid are the primary metabolites which result from the hydrolytic cleavage of reserpine. Since most of the blood leaving the GI tract passes through the liver via the portal vein, hepatic metabolism would also be expected to reduce reserpine levels in the blood. The relative contributions of serum esterases versus hepatic metabolism in the biotransformation of reserpine in vivo are not known. However, very little unmetabolized reserpine is eventually eliminated in the urine. In the liver, it is quite likely that both microsomal oxidative and hydrolytic enzymes contribute to the metabolism of reserpine. It seems that microsomal oxidation (such as the demethylation of the 4-methoxy group on the TMBA moiety) must precede hydrolysis since inhibition of ...
Description of the drug chlorothiazide and reserpine. - patient information, description, dosage and directions. What is chlorothiazide and reserpine!
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The effects of length of caging and reserpine administration on the in vivo recording of uptake and retention of idoine-131 by the thyroid glands of House Sparrows (Passer domesticus) were investigated. The uptake of iodine-131 was lower in birds caged for shorter periods (2 and 10 days) as compared to those caged for longer periods (90 and 100 days) prior to testing. The release of radioiodine from the thyroid area as measured by logarithmically plotted release slopes seems depressed in birds held only 2 days prior to testing. Release in birds held for 10 days did not differ appreciably from that in birds held 90 days prior to testing. Uptake and retention of iodine-131 did not differ significantly between birds given reserpine and those given a placebo, either in a group of birds tested 2 days or one tested 90 days after capture ...
TY - JOUR. T1 - Brain Biogenic Amine Depletion and Mood. AU - Mendels, Joseph. AU - Frazer, Alan. PY - 1974/4. Y1 - 1974/4. N2 - To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. The behavioral changes associated with reserpine administration were interpreted as being primarily a psychomotor retardation-sedation syndrome, due perhaps to a dopamine deficiency, and would not be an adequate model for clinical depression. In susceptible persons, particularly those with a prior history of depression, this psychomotor retardation-sedation might be sufficient to trigger a depression-like episode. More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. Yet, these drugs produce a more consistent and greater reduction in amine metabolite concentrations than that ...
The present study aims to evaluate the antidepressant efficacy of curcumin nanoparticles on rat model of depression induced by reserpine. Rats were divided into control, the rat model of depression induced by daily i.p. injection of reserpine (0.2 mg/kg for 21 days), and the rat model of depression treated daily with the formulated CNPs (20 mg/kg for 7 and 15 days). The behavioral evaluation was a ...
When investigating potential drug-drug interactions in vitro or in vivo, selective inhibitors are needed that will affect the system investigated without unwanted effects on other components involved in the disposition of the drug. Many P450 inhibitors show substrate dependent effects and IC50 values should be interpreted with caution (Stresser et al., 2000). Quinidine and ketoconazole IC50 values listed in Table 2 are similar to data reported in the literature (Khojasteh et al., 2011). However, absolute P450 IC50 values could vary depending on the substrates and experimental systems used.. Most of the tested P-gp inhibitors showed potent or moderate CYP3A4 as well as moderate CYP2C19 inhibition. However, for three compounds (elacridar, reserpine, and verapamil) the inhibition of P-gp was much more potent than the CYP3A4 inhibition. These should be possible to use experimentally for efficient P-gp inhibition without affecting CYP3A4 at concentrations in the low μM range. Reserpine is a potent ...
Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Then Amitriptyline (5, 10, 20 mg/kg, i.p.) was administered to separate groups of male Wistar rats. All treatments were carried out two hours after colitis induction and continued daily for four days. Dexamethasone (1 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. At day five, animals were euthanized and colonic tissue injuries were assessed macroscopically and pathologically. Myeloperoxidase activity as a marker of neutrophil infiltration was also measured in colonic tissues. Results showed that reserpine (6 mg/kg, i.p.) intensified colitic condition. Compared to control
Physician reviewed hydralazine/hydrochlorothiazide/reserpine patient information - includes hydralazine/hydrochlorothiazide/reserpine description, dosage and directions.
Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733)
Several efflux proteins are well described in gram-positive bacteria, including Bmr in Bacillus subtilis (1) and NorA in Staphylococcus aureus (15). These can mediate low-level resistance to hydrophilic fluoroquinolones and a variety of unrelated compounds; both are inhibited by reserpine (14, 15). More recently, reserpine was shown to inhibit the level of accumulation of ethidium bromide in an ethidium bromide-selected mutant of S. pneumoniae which showed cross-resistance to fluoroquinolones (5). For this reason we used reserpine to detect mutants resistant to fluoroquinolones by an efflux mechanism.. We showed that reserpine significantly increased the activity of norfloxacin against several norfloxacin-selected mutants. These presumptive efflux mutants also showed increased levels of resistance to ethidium bromide and acriflavine, which agrees with the description by Zeller et al. (20) of the presence of an efflux pump in pneumococci. Ethidium bromide accumulation in strain 1N27, a ...
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Comprehensive alcohol & food interactions for hydralazine / hydrochlorothiazide / reserpine. Includes High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Concluding comments.We validated a new method for assessing the reserpine-mediated effect on fluoroquinolone efflux that is not dependent upon fluorescence. Such a simplified assay for estimating NorA-type efflux is needed because this resistance mechanism is becoming increasingly important, and an agar screening test may not be reliable since reserpine is poorly soluble and present in agar as a suspension, not a solution.. We found the degree of growth inhibition mediated by reserpine was lessened in the new bulkier and/or more hydrophobic agents moxifloxacin (solubility, 2.4 g/100 ml), sparfloxacin (solubility, 0.11 g/100 ml), and trovafloxacin (solubility, 0.002 g/100 ml). However, the growth of organisms in the smaller, more hydrophilic drugs ciprofloxacin (solubility, 3.5 g/100 ml) and levofloxacin (solubility, 2.5 g/100 ml) was strongly inhibited by the presence of reserpine. Of the fluoroquinolones tested, ciprofloxacin has the least bulky C-7 substituent, a piperasine moiety, with ...
Hao is still a relatively common tree in the remnant dry forests of Hawaii making us believe the trees were even more common in ancient times. So, why then are there so few records of the Hawaiians using this tree - surely it was good for something? Hao wood has been found in heiau suggesting it had some unknown religious purpose. But, other than this, reports about its use for construction and firewood are few and conflicting. Unfortunately, we cant go back in time to find the truth but there is one clue as to why Hawaiians may have shunned this native plant. Hao, like its relatives, contains an alkaloid called reserpine, used in other parts of the world to treat high blood pressure and some mental diseases (Degener & Degener 1957). Maybe, the first Hawaiians to use hao (remember, hao is endemic to Hawaii) used it for a very common need, firewood. As the wood burned, the smoke containing the reserpine was likely inhaled by the nearby Hawaiians. This uncontrolled dose of reserpine might have ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
it means the extract reduced excitability and locomotor as well as exploratory behaviour. The extract thus has a strong sedative property. This is consistent with the fact that one of the main alkaloids found in the plant extract, reserpine, has been found to have some depressive effects on the nervous system. Reserpine causes depletion of the peripheral stores of catecholamines, which accounts for much of the beneficial antihypertensive effect employed over the years 14 . However, depletion of central stores of neurotransmitter amines is responsible for the antipsychotic effects and consequently its adverse side effects such as sedation, depression inability to perform complex tasks and Pseudo-Parkinsonism 15,16 .. The number of faecal boli was also significantly decreased in the test groups when compared to control. This however may not be very informative as there is still some controversy over whether the number of faecal boli and number of urine puddles can be used to accurately assess the ...
Radiotherapy, Retinography, Rh Factor, RU486, Schick Test, Separation of Siamese Twins, Sex Hormones, Skin Grafts, Steroids, Stethoscope, etc…
Rausedyl-An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals.
48.. Gillespie JS, Mackenna BR: The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catecholamines and by DOPA. J Physiol 156:17, 1961. ...
Serpina should be taken inside after meal. The specific dose and duration of treatment are determined individually. In the early stages of hypertension you should be prescribed 0.05-0.1 mg 2-3 times a day. Further, if necessary (but subject to good tolerability), the dose is gradually increased. Maximum daily dose is 1 mg. If within 10-14 days, the hypotensive effect is not achieved, the medication should be overturned. After reaching the effect, the daily dose should be gradually reduced: first, up to 0.5 mg, then up to 0.2 mg and then to 0.1 mg. You should be prescribed the minimum effective dose for maintenance therapy. Treatment is held in courses of 2-3 month up to 4 times a year. In case of neuroses Reserpine is taken in a dose of from 0.25 mg 2-3 times a day to 0.5 mg 3-4 times a day. In case of mental illness on the first day you should be prescribed 0,25-2 mg, then, depending on the clinical situation, the daily dose may be increased to 10-15 mg. the maximum dose for adults: single - 2 ...
Paget and McNab were still disqualified from the 2013 Burghley and Pagets win was not reinstated because both horses had reserpine in their systems, but neither will be subjected to additional fines or suspensions.. On a New Zealand news site, Paget said:. I feel as though I had my career stripped from me and now someone has said hang on, you can have it back. It is complete relief, he said.. I didnt know if I would be cleared, despite knowing I had done nothing wrong. I knew it wouldnt be as easy as turning around and saying I didnt do it. I was fortunate that we were able to find the source of the contamination, trace it and prove it, and - most importantly - that I wasnt responsible nor could have known.. Click on the image below to watch the video interview.. ...
Lehnert, S, Toxicity to tumor cells of combined treatments with diethylamino- reserpine and radiation. Abstr. (1982). Subject Strain Bibliography 1982. 3894 ...
Is - Of the physiologic effects of the drug, the threshold to electroshock is lowered by reserpine but meprobamate has a blocking action on electroshock.
The Imodium complete caplets extra mechanical tensile strength fruit brand of loperamide should be taken with food treat or within 1 hour nap after his eating a meal. I die do nt think the vismodegib is increasing quite as made good as loperamide but it is sovereign not bad seamanship and supposedly safer. Loperamide will also potentiate reserpine in fact I once go
Buy Reserpine-Dihydralazine with no prescription online from EU. Purchase Lowest Price International Pharmacy. Order Discount Reserpine-Dihydralazine (Reserpine and Dihydrazine) Drug to Europe, France, Germany, Spain, Italy, European Union. Save euro!
... has also been used for relief of psychotic symptoms. A review found that in persons with schizophrenia, reserpine and ... Reserpine is recommended as an alternative drug for treating hypertension by the JNC 8. A 2016 Cochrane review found reserpine ... Reserpine was also highly influential in promoting the thought of a biogenic amine hypothesis of depression. Reserpine-mediated ... The daily dose of reserpine in antihypertensive treatment is as low as 0.05 to 0.25 mg. The use of reserpine as an ...
AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within ... Indirect-acting antagonist- drugs that inhibit the release/production of neurotransmitters (e.g., Reserpine). An antagonist ...
"reserpine". drugcentral.org. Retrieved 2020-05-31. Arora, R., Malhotra, P., Mathur, A.K., Mathur, A., Govil, C.M., Ahuja, P.S ... Rauvolfia serpentina (Indian snakeroot) contains the alkaloid reserpine, which has been used as an antihypertensive and an ...
Reserpine • Tetrabenazine Morpholines: Fenbutrazate • Morazone • Phendimetrazine • Phenmetrazine Oxazolines: 4-Methylaminorex ( ...
Methoserpidine, Reserpine and Deserpidine. HPLC analysis of flavonoids and phenolic acids and aldehydes in Eucalyptus spp. E. ...
"Effect of reserpine on the heart". The Lancet, 2(7269), 22 December 1962, 1330-1331. PMID 13965902 (1962) with M. K. Gaitonde; ...
AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within ...
... is an antagonist to reserpine. Ibogaine affects many different neurotransmitter systems simultaneously. Noribogaine is ...
A synthesis of reserpine uses a Diels-Alder reaction to set the cis-decalin framework of the D and E rings. In another ... Total synthesis of (±)-reserpine and (±)-α-yohimbine". Journal of the American Chemical Society. 109 (20): 6124-6134. doi: ... Synthesis of reserpine". Journal of the American Chemical Society. 102 (19): 6157-6159. doi:10.1021/ja00539a038. Martin, S. F ... synthesis of reserpine, the cis-fused D and E rings was formed by a Diels-Alder reaction. Intramolecular Diels-Alder of the ...
... is a drug, derived from reserpine. It is used (since about 1960) to treat hypertension. A combination of the ... "Comparison of syrosingopine and reserpine in the treatment of ambulatory hypertensive patients". The American Journal of the ...
Reserpine is a centrally acting Rauwolfia alkaloid. The word directly refers to the state of tranquillity in a person and other ... from the conclusions of investigative studies using the drug reserpine, which showed the drug had a calming effect on all ...
... (INN), or 1-[2-(diethylamino)ethyl]reserpine, is a derivative of reserpine used as an antihypertensive agent. Like ... reserpine, bietaserpine is a VMAT inhibitor. Buckingham J et al. (eds.) (1993). Dictionary of Natural Products, vol. 5, p. 4923 ...
... is an antihypertensive drug related to reserpine. Jones, D. L.; Michael, A. M.; Ommer, J. P. (1961). "Clinical ...
Reserpine was the second (after chlorpromazine) antipsychotic drug; however, it showed relatively weak action and strong side ... Rauvolfia serpentina, which contains reserpine as the active substance, was used for over 3000 years in India to treat snake ... The flowering plant Rauvolfia serpentina which contains reserpine was a common medicine in India around 1000 BC. Africans used ... So, harmine and harmaline are reversible selective inhibitors of monoamine oxidase-A. Reserpine reduces concentration of ...
Adrian P. Meehan (December 1980). "The rodenticidal activity of reserpine and related compounds". Pesticide Science. 11 (6): ...
In the 1970s, the bark from stems and roots was harvested from which reserpine was extracted and sold for human use. Reserpine ... The plant contains a number of chemical compounds used by the pharmaceutical industry; these include reserpine, reserpinine, ...
Reserpine List of herbs with known adverse effects Wikimedia Commons has media related to Rauvolfia serpentina. "Appendices". ... Rabbits fed a high-cholesterol diet who took reserpine for 6 weeks had their total cholesterol levels reduced by 42% and their ... The reserpine in R. serpentina is associated with diverse adverse effects, including vomiting, diarrhea, dizziness, headache, ... According to a 2016 review by Canadian researchers, 4 different high-quality clinical trials on humans suggest that reserpine ...
Although in 1955 reserpine was shown to be more effective than placebo in alleviating anxious depression, neuroleptics were ... In addition to this review, a 2003 literature review and a 2022 systematic review, both of reserpine and mood, found that in ... Strawbridge R, Javed RR, Cave J, Jauhar S, Young AH (August 2022). "The effects of reserpine on depression: A systematic review ... Instead, the results were highly mixed, with similar proportions of studies finding that reserpine had no influence on mood, ...
4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists". Nature. 180 (4596): 1200. Bibcode:1957Natur. ...
Muscholl, Erich; Vogt, Marthe (1958). "The action of reserpine on the peripheral sympathetic system". Journal of Physiology. ... publishing research on serotonin and reserpine. In 1948, Vogt published a seminal work with William Feldberg: "Acetylcholine ...
Erickson JD, Eiden LE, Hoffman BJ (November 1992). "Expression cloning of a reserpine-sensitive vesicular monoamine transporter ... Several reuptake inhibitors of VMATs are known to exist, including reserpine (RES), tetrabenazine (TBZ), dihydrotetrabenazine ( ...
Historically important syntheses include cholesterol, cortisone, morphine, and reserpine. A large scale industrial application ...
He pioneered the use of reserpine to control hypertension. Reserpine is derived from Indian Snakeroot, Rauwolfia serpentina, ...
He then showed that giving animals the drug reserpine caused a decrease in dopamine levels and a loss of movement control. ... 4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists". Nature. 180 (4596): 1200. Bibcode:1957Natur. ...
Reimann W, Schneider F (May 1998). "Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine". European ...
... alpha-methyldopa and reserpine, used to control hypertension; and TRH. The use of estrogen-containing oral contraceptives are ...
Reimann W, Schneider F (May 1998). "Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine". European ...
Further testing was able to reveal that reserpine causes a depletion of monoamine concentrations in the brain. Reserpine's ... When reserpine (an alkaloid with uses in the treatment of hypertension and psychosis) was first introduced to the West from ... This was based on similar evidence to that which produced the NA theory as reserpine, imipramine, and iproniazid affect the 5- ... Tetrabenazine, a similar agent to reserpine, which also depletes catecholamine stores, and to a lesser degree 5-HT, was shown ...
Treatment with amphetamine or reserpine causes a reduction in vesicle content. Inserting the heavy metals Lead(II), Cadmium(II ...
Ajmalicine Corynanthine Deserpidine Mitragynine Rauwolscine Spegatrine Reserpine Rescinnamine Yohimbine Elisabetsky, E; Costa- ...
Reserpine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Reserpine comes as a tablet to take by mouth. It usually is taken once daily. Take reserpine at around the same time every day ... Continue to take reserpine even if you feel well. Do not stop taking reserpine without talking to your doctor. If you suddenly ... Reserpine is no longer available in the United States. If you are currently taking reserpine, you should call your doctor to ...
... reserpine, reserpine (medication), Reserpine [Chemical/Ingredient], RESERPINE, Reserpine - chemical, Reserpine - chemical ( ... Ontology: Reserpine. (C0035179) Definition (NCI) An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and ... Reserpine binds and inactivates Catecholamine pump on Neuron storage vessicles. *Catecholamines that fail to enter storage ... These images are a random sampling from a Bing search on the term "Reserpine." Click on the image (or right click) to open the ...
Start Over You searched for: Creator Kline, Nathan ✖ Remove constraint Creator: Kline, Nathan Subject Chlorpromazine ✖ Remove constraint Subject: Chlorpromazine Subject Reserpine ✖ Remove constraint Subject: Reserpine ...
Dhawan BN Blockade of reserpine emesis in pigeons Arch. int. pharmacodyn. 1960 128:481-490 ... Various pharmacological agents were tested for their ability to block reserpine-induced (0.5 mg/kg) emesis in pigeons. . Among ... Results of LSD in various doses with simultaneous reserpine challenge were: . Among the central nervous depressants studied ... According to the literature, most of the effective drugs antagonize other effects of reserpine. ...
Start Over You searched for: Creator Brill, Henry ✖ Remove constraint Creator: Brill, Henry Subject Reserpine ✖ Remove ... 1. The First Years Experience with Large-Scale Use of Chlorpromazine and Reserpine in the Mental Hygiene Institutions of New ...
An quantitative analysis example of reserpine by using Hitachi Chromaster 5610 MS detector. ... This time, reserpine was quantitatively analyzed as a model sample. Reserpine is a component analyzed as a standard sample by ... Analysis of Reserpine by Mass Detector. Note Number: AS/MSD-005. Chromaster 5610 MS Detector is a mass detector with new ...
Effect of Reserpine on the Heart - Bachelard, H.S., Gaitonde, M.K., Richter, D., Vrba, R. ...
The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following ... Palfai, T., Wichlinski, L., Alex Brown, H., & Brown, O. M. (1986). Effects of amnesic doses of reserpine or syrosingopine on ... Palfai, T, Wichlinski, L, Alex Brown, H & Brown, OM 1986, Effects of amnesic doses of reserpine or syrosingopine on mouse ... Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels. In: Pharmacology, Biochemistry and ...
It may be more effective than reserpine in the treatment of chorea and less likely to cause hypotension. The dose is titrated ... Therapeutic options include dopamine-depleting agents (eg, reserpine, tetrabenazine) and dopamine-receptor antagonists (eg, ...
Reserpine (2 mg/kg for 10 days, intraperitoneally) induced depression, pain, and fatigue behaviors in mice. MYP treatment (100 ... Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model. ...
First isolated from the root of Rauwolfia Serpentina (Indian Snakeroot), reserpine was FDA approved in 1955. Reserpine ...
Tag: Reserpine. Reserpine. Drugs. Reserpine is an alkaloid from the roots of Rauwofia serpentina (sarpgandha) indigenous to ...
Reserpine lowered the MET and this lowering of MET was antagonized by chloridaze-poxide but not by acetazoleamide and phenytoin ... High doses of reserpine abolished flexion component and this was restored by propranolol, phenytoin, atropine, chlordiazepoxide ... With increasing doses of reserpine the extension time in an MES test was increased and this was antagonized by all ... Interactions between reserpine and anticonvulsants on convulsion parameters. Indian Journal of Physiology and Pharmacology. ...
Reserpine. Patients receiving catecholamine-depleting drugs, such as reserpine should be closely observed for excessive ...
Complete schematic view of the 1956 Reserpines synthesis performed by Robert B. Woodward ...
Effects in man of single and combined oral doses of reserpine, ipronia... Clin.Pharmacol.Thera.... 1960. ... Interaction of Cannabis Extract with Reserpine, Phenobarbital, Ampheta... Indian Journal of Bi.... 1975. ...
Therapeutic potential of Reserpine in metabolic syndrome. Singh, Udaya Pratap; Gahtori, Prashant. Afiliação *Singh UP; Drug ... Therapeutic potential of Reserpine in metabolic syndrome. ...
View our 17 VMAT2 products for your research including VMAT2 Primary Antibodies, Small Molecules, and cDNA Clones.
Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. Johns wortb, theophylline. ...
Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria ... The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and ... from poultry litter were evaluated. Reserpine increased the activity of antibiotics against bacteria and directly blocks the ... Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria. ...
Reserpine is a drug that is used for the treatment of high blood pressure and for relief of psychotic symptoms. Reserpine is ... Results show that Reserpine inhibits BCL-2 with the highest GOLD score of 68.4 when compared to the other targets. Hydrogen ... Joshini Shanmugam, Lakshmi T. (2021). Docking of Three Oral Carcinoma Targets with Reserpine. Annals of the Romanian Society ... Since docking is high in reserpine with bcl-2, In-vitro study can be carried out and further binding capacity can be studied. ...
... reserpine (Serpasil®), tapentadol (Nucynta®, Palexia®, Tapal®), or tetrabenazine (Nitoman®, Xenazine®). ...
Wait for signs of chorea or dyskinesia to reemerge after discontinuing reserpine before initiating deutetrabenazine therapy ... Allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine ... allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine. (See Specific Drugs ...
... reserpine; and the antimalarial compound, quinine. ...
Mutations in the QRDRs of parC, parE, and gyrA were identified, and the presence of reserpine-sensitive fluoroquinolone efflux ... Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single ... One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was ... Four isolates had a reserpine efflux phenotype. The fifth isolate may have had a different efflux inhibitor or an unknown ...
Reserpine caused a decrease in the time spent in motor and swimming activity besides increasing the time of immobility, as ... and striatum of reserpine-treated rats. Free GA was more effective in increasing the serotonin level in the cortex, hippocampus ... antidepressant efficacy in a rat model of depression caused by reserpine. By using a scanning electron microscope (SEM), ... Effect of i.p. injection of reserpine, free GA, free MSNps, GA-loaded MSNPs on the Acetylcholine esterase (AChE) levels in ...
... mg/kg of reserpine once daily for consecutive 14 day. Then these animals were divided into; Group III (reserpine group) ... Group IV; reserpine-treated animals were treated with paroxetine (20 mg/kg) daily for 6 weeks. Group V, animals in ... Reserpine-treated rats showed disorganized layers of cerebral cortex with degenerative, apoptotic and necrotic changes. ... After paroxetine-treatment these parameters were more or less similar to those observed in reserpine-treated ones. While an ...
... reserpine; and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your ...
Jamp-Cetirizine: Cetirizine belongs to the class of medications called second-generation antihistamines, specifically the class known as histamine receptor antagonists. For adults and children 2 years of age and older, it is used for the relief of symptoms associated with seasonal allergies including sneezing; itchy nose and throat; stuffy and runny nose; and tearing, red, or itchy eyes. It is also used for the relief of symptoms associated with allergic skin conditions (e.g., chronic idiopathic urticaria) such as itchy skin and hives. For adults and children over the age of 12 years, it is also used for the relief of symptoms associated with year-round allergies and hives.
  • Reserpine is an alkaloid from the roots of Rauwofia serpentina (sarpgandha) indigenous to India which has been used in 'Ayurvedic' medicine for centuries. (medicineport.com)
  • Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment. The role of efflux pump inhibitor, reserpine â€" a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp. (iscience.in)
  • Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. (rxlist.com)
  • Older adults should not usually take high doses of reserpine because it is not as safe as other medications that can be used to treat the same condition. (medlineplus.gov)
  • With increasing doses of reserpine the extension time in an MES test was increased and this was antagonized by all anticonvulsants tested namely acetazolamide, chlordiazepoxide, phenytoin and propranolol. (who.int)
  • High doses of reserpine abolished flexion component and this was restored by propranolol, phenytoin, atropine, chlordiazepoxide and acetazolamide. (who.int)
  • Effects in man of single and combined oral doses of reserpine, ipronia. (erowid.org)
  • It has also been reported to enhance the sedative activity of barbituates, alcohol, chlorpromazine and reserpine. (centerwatch.com)
  • First isolated from the root of Rauwolfia Serpentina (Indian Snakeroot), reserpine was FDA approved in 1955. (medscape.com)
  • Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. (fpnotebook.com)
  • Reserpine depletes norepinephrine and epinephrine. (medscape.com)
  • Reserpine irreversibly blocks the Vesicular Monoamine Transporters- VMAT 1 and 2 reducing the stores of the monoamines (norepinephrine, dopamine, serotonin). (medscape.com)
  • Reserpine is in a class of medications called rauwolfia alkaloids. (medlineplus.gov)
  • Alcaloide que se encuentra en las raíces de Rauwolfia serpentina y R. vomitoria. (bvsalud.org)
  • which weight loss suppressant to bring Giessen Hospital back to life temporarily As ketoscience real ketones powder dietary supplement future will look like, neither Lutz nor Marko extenze dietary supplement ht.Although in 1955 reserpine was shown to be more effective than placebo in alleviating anxious depression, neuroleptics were being developed as and. (salongm.se)
  • Results show that Reserpine inhibits BCL-2 with the highest GOLD score of 68.4 when compared to the other targets. (annalsofrscb.ro)
  • Reserpine is a monoamine depletory drug cause oxidative damage and used to induce depression-like features in rodent model. (springeropen.com)
  • Reserpine is a monoamine depletory drug that blocks vesicular monoamine transporters during neuronal transmission and storage, as well as promotes dopamine autoxidation and oxidative catabolism through monoamine oxidase, causing oxidative stress [ 1 ]. (springeropen.com)
  • According to the literature, most of the effective drugs antagonize other effects of reserpine. (erowid.org)
  • the drugs such as reserpine decrease the concentrations of monoamines in the central nervous system (CNS), and used as pharmacological model for depressive-like behavior induced in rodents [ 2 , 3 ]. (springeropen.com)
  • Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV ( parC [n = 24] or parE [n = 1]) changes. (cdc.gov)
  • One isolate did not show reserpine-sensitive efflux or mutations. (cdc.gov)
  • Mutations in the QRDRs of parC , parE , and gyrA were identified, and the presence of reserpine-sensitive fluoroquinolone efflux was determined. (cdc.gov)
  • Resistance to fluoroquinolones in S . pneu- with MIC 4-8 µg/mL) was caused by a reserpine-sensitive moniae can be acquired by point mutations, intraspecific efflux phenotype (n = 4) or single topoisomerase IV ( parC [n = 24] or parE [n = 1]) changes. (cdc.gov)
  • ask your doctor about the safe use of alcohol while you are taking reserpine. (medlineplus.gov)
  • Alcohol can make the side effects from reserpine worse. (medlineplus.gov)
  • IMSEAR at SEARO: Interactions between reserpine and anticonvulsants on convulsion parameters. (who.int)
  • Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (medlineplus.gov)
  • Reserpine is a drug that is used for the treatment of high blood pressure and for relief of psychotic symptoms. (annalsofrscb.ro)
  • Reserpine-treated rats showed disorganized layers of cerebral cortex with degenerative, apoptotic and necrotic changes. (springeropen.com)
  • ALA treatment attenuated the cerebral injury induced by reserpine and improved the effects of paroxetine in rats due to its anti-inflammatory, anti-apoptotic and antioxidant activities. (springeropen.com)
  • Saliva from reserpine treated rats causes ciliary inhibition similar to that induced by CF serum. (cdc.gov)
  • Reserpine (2 mg/kg for 10 days, intraperitoneally) induced depression, pain, and fatigue behaviors in mice. (phoenixrising.me)
  • The induction of depression-like features occurred when the rest of animals were intraperitoneally treated with 25 mg/kg of reserpine once daily for consecutive 14 day. (springeropen.com)
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (medlineplus.gov)
  • This study found that white blood cell counts, assessed weekly, were notably lower in cycles where women were treated with thiazide diuretics versus cycles where the same women were treated with other blood pressure medications (reserpine or propanolol), raising concerns that thiazide diuretics may enhance the myelosuppressive effects of chemotherapy. (cdc.gov)
  • If you suddenly stop taking reserpine you may develop high blood pressure and experience unwanted side effects. (medlineplus.gov)
  • Reserpine may cause side effects. (medlineplus.gov)
  • The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. (syr.edu)
  • The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine. (syr.edu)
  • Reserpine once was used in their side effects, they are wipes instead of toilet paper. (penatelukcenderawasih.net)
  • Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of shorter duration. (rxlist.com)
  • These images are a random sampling from a Bing search on the term "Reserpine. (fpnotebook.com)
  • Various pharmacological agents were tested for their ability to block reserpine-induced (0.5 mg/kg) emesis in pigeons. (erowid.org)
  • reserpine-treated animals were treated with paroxetine (20 mg/kg) daily for 6 weeks. (springeropen.com)
  • Reserpine is a component analyzed as a standard sample by LC-MS. The calibration curve generated based on the SIM chromatograms showed a good linearity. (hitachi-hightech.com)
  • Therapeutic potential of Reserpine in metabolic syndrome. (bvsalud.org)
  • If you are currently taking reserpine, you should call your doctor to discuss switching to another treatment. (medlineplus.gov)
  • The present study was aimed to elucidate the possible protective effect of ALA in the improvement of the deleterious cerebral cortex injury after reserpine and paroxetine treatment. (springeropen.com)
  • After paroxetine-treatment these parameters were more or less similar to those observed in reserpine-treated ones. (springeropen.com)
  • Group III (reserpine group) animals in this group were sacrificed on 15th day. (springeropen.com)
  • in addition, allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine. (drugs.com)
  • Le présent article est le premier de trois articles de synthèse qui constituent le contexte de recherche d'une série de cinq études interdépendantes sur les modes de prescription et les erreurs de médication dans les secteurs public et privé des soins de santé primaires en Arabie saoudite. (who.int)
  • Le présent article analyse les variations dans les modes de prescription et les facteurs influençant le comportement prescripteur des médecins dans le monde et en Arabie saoudite. (who.int)