Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Iproniazid
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
alpha-Methyltyrosine
Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Tetrabenazine
Chlorpromazine
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Mephentermine
Catecholamine Plasma Membrane Transport Proteins
Secologanin Tryptamine Alkaloids
Biogenic Amines
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Sympathomimetics
Adrenal Medulla
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Vesicular Monoamine Transport Proteins
Vesicular Biogenic Amine Transport Proteins
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Normetanephrine
Fenclonine
Chromaffin Granules
Monoamine Oxidase Inhibitors
17-Hydroxycorticosteroids
Methyldopa
Pharmacology
Phenoxybenzamine
Synephrine
Methysergide
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Chromaffin System
Vas Deferens
Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Chlorisondamine
Tranquilizing Agents
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Desipramine
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
5-Hydroxytryptophan
Dextroamphetamine
The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
Ephedrine
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Metaraminol
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Dihydroxyphenylalanine
Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart. (1/855)
[11C]Phenylephrine (PHEN) is a radiolabeled analogue of norepinephrine that is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and taken up into storage vesicles localized within the nerve varicosities by the vesicular monoamine transporter. PHEN is structurally related to two previously developed sympathetic nerve markers: [11C]-meta-hydroxyephedrine and [11C]epinephrine. To better characterize the neuronal handling of PHEN, particularly its sensitivity to neuronal monoamine oxidase (MAO) activity, kinetic studies in an isolated working rat heart system were performed. METHODS: Radiotracer was administered to the isolated working heart as a 10-min constant infusion followed by a 110-min washout period. Two distinctly different approaches were used to assess the sensitivity of the kinetics of PHEN to MAO activity. In the first approach, oxidation of PHEN by MAO was inhibited at the enzymatic level with the MAO inhibitor pargyline. In the second approach, the two hydrogen atoms on the a-carbon of the side chain of PHEN were replaced with deuterium atoms ([11C](-)-alpha-alpha-dideutero-phenylephrine [D2-PHEN]) to inhibit MAO activity at the tracer level. The importance of vesicular uptake on the kinetics of PHEN and D2-PHEN was assessed by inhibiting vesicular monoamine transporter-mediated storage into vesicles with reserpine. RESULTS: Under control conditions, PHEN initially accumulated into the heart at a rate of 0.72+/-0.15 mL/min/g wet. Inhibition of MAO activity with either pargyline or di-deuterium substitution did not significantly alter this rate. However, MAO inhibition did significantly slow the clearance of radioactivity from the heart during the washout phase of the study. Blocking vesicular uptake with reserpine reduced the initial uptake rates of PHEN and D2-PHEN, as well as greatly accelerated the clearance of radioactivity from the heart during washout. CONCLUSION: These studies indicate that PHEN kinetics are sensitive to neuronal MAO activity. Under normal conditions, efficient vesicular storage of PHEN serves to protect the tracer from rapid metabolism by neuronal MAO. However, it is likely that leakage of PHEN from the storage vesicles and subsequent metabolism by MAO lead to an appreciable clearance of radioactivity from the heart. (+info)Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (2/855)
Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa. (+info)A possible mode of cardiovascular actions of dopamine in dogs. (3/855)
A possible mode of cardiovascular actions of dopamine was studied using ephedrine. In the dog pretreated with repeated administrations of ephedrine (total dose, 40 or 80 mg/kg, i.v.) or with combined administrations of ephedrine (total dose, 90 mg/kg, s.c. and i.v.) and reserpine (2 mg/kg, s.c., 24 hr previously), pressor responses to dopamine were eliminated and reversed to depressor responses whereas depressor responses to dopamine were potentiated. Positive chronotropic effects of dopamine were almost eliminated. Pressor and positive chronotropic effects of tyramine were almost abolished. Sympathomimetic effect of noradrenaline and adrenaline were potentiated while those of isoprenaline were inhibited. In the heart-lung preparation of ephedrine-treated dogs (total dose, 40 mg/kg, i.v.), cardiac stimulating effects of dopamine and tyramine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent. In the open-chest dogs, after pretreatment of cocaine (4 mg/kg, i.v.), pressor, positive inotropic and chronotropic effects of noradrenaline were potentiated, whilst those of tyramine were inhibited. Those of dopamine were not visibly altered, but depressor, negative chronotropic and inotropic effects of dopamine appeared at small doses. In the ephedrine-pretreated dogs, these sympathomimetic effects of dopamine and tyramine after cocaine were strongly depressed and those of noradrenaline were inhibited to a certain degree. The results obtained with ephedrine suggest that dopamine differs from other catecholamines and tyramine in the mode of cardiovascular actions. (+info)Pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2-(3H)-furylidene]-1,3-cyclopentanedione (oudenone). (4/855)
The pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2(3H)-furylidene]-1,3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10--40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized rats. In unanesthetized spontaneously hypertensive rats (SHR), oudenone (5--200 mg/kg p.o.) caused a dose-related decrease in the systolic blood pressure. The initial pressor effect was diminished by pretreatments with phentolamine, guanethidine, hexamethonium and was abolished in the pithed rats. In addition, intracisternal administrations of oudenone (100--600 mug/kg) showed a marked increase in blood pressure in the anesthetized rats, suggesting that the pressor effect may be due to centrally mediated actions. Oudenone, given intra-arterially into the femoral artery (400--800 mug/kg), caused a long-lasting vasodilation in anesthetized dogs. At a relatively high dose (40 mg/kg i.v.), oudenone antagonized all pressor responses to autonomic agents and central vagus nerve stimulation in anesthetized rats and dogs, however, oudenone showed no anti-cholinergic,-histaminergic, beta-adrenergic and adrenergic neuron blocking properties. (+info)The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. (5/855)
The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether beta-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that beta3-adrenergic receptors and classical beta1/beta2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue. (+info)The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (6/855)
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested. (+info)Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. (7/855)
Methamphetamine (METH) is a powerful psychostimulant that is increasingly abused worldwide. Although it is commonly accepted that the dopaminergic system and oxidation of dopamine (DA) play pivotal roles in the neurotoxicity produced by this phenylethylamine, the primary source of DA responsible for this effect has remained elusive. In this study, we used mice heterozygous for vesicular monoamine transporter 2 (VMAT2 +/- mice) to determine whether impaired vesicular function alters the effects of METH. METH-induced dopaminergic neurotoxicity was increased in striatum of VMAT2 +/- mice compared with wild-type mice as revealed by a more consistent DA and metabolite depletion and a greater decrease in dopamine transporter expression. Interestingly, increased METH neurotoxicity in VMAT2 +/- mice was accompanied by less pronounced increase in extracellular DA and indices of free radical formation compared with wild-type mice. These results indicate that disruption of vesicular monoamine transport potentiates METH-induced neurotoxicity in vivo and point, albeit indirectly, to a greater contribution of intraneuronal DA redistribution rather than extraneuronal overflow on mediating this effect. (+info)Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine. (8/855)
Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics. (+info)
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Treatment of Hypertension with Reserpine,with Reserpine in Combination with Pentapyrrolidinium,and with Reserpine in...
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Reserpine
... has also been used for relief of psychotic symptoms. A review found that in persons with schizophrenia, reserpine and ... Reserpine is recommended as an alternative drug for treating hypertension by the JNC 8. A 2016 Cochrane review found reserpine ... Reserpine was also highly influential in promoting the thought of a biogenic amine hypothesis of depression. Reserpine-mediated ... The daily dose of reserpine in antihypertensive treatment is as low as 0.05 to 0.25 mg. The use of reserpine as an ...
Neurotransmitter
AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within ... Indirect-acting antagonist- drugs that inhibit the release/production of neurotransmitters (e.g., Reserpine). An antagonist ...
Apocynaceae
"reserpine". drugcentral.org. Retrieved 2020-05-31. Arora, R., Malhotra, P., Mathur, A.K., Mathur, A., Govil, C.M., Ahuja, P.S ... Rauvolfia serpentina (Indian snakeroot) contains the alkaloid reserpine, which has been used as an antihypertensive and an ...
List of dopaminergic drugs
Reserpine • Tetrabenazine Morpholines: Fenbutrazate • Morazone • Phendimetrazine • Phenmetrazine Oxazolines: 4-Methylaminorex ( ...
Eudesmic acid
Methoserpidine, Reserpine and Deserpidine. HPLC analysis of flavonoids and phenolic acids and aldehydes in Eucalyptus spp. E. ...
Rudolf Vrba
"Effect of reserpine on the heart". The Lancet, 2(7269), 22 December 1962, 1330-1331. PMID 13965902 (1962) with M. K. Gaitonde; ...
Neuromodulation
AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within ...
Ibogaine
... is an antagonist to reserpine. Ibogaine affects many different neurotransmitter systems simultaneously. Noribogaine is ...
Diels-Alder reaction
A synthesis of reserpine uses a Diels-Alder reaction to set the cis-decalin framework of the D and E rings. In another ... Total synthesis of (±)-reserpine and (±)-α-yohimbine". Journal of the American Chemical Society. 109 (20): 6124-6134. doi: ... Synthesis of reserpine". Journal of the American Chemical Society. 102 (19): 6157-6159. doi:10.1021/ja00539a038. Martin, S. F ... synthesis of reserpine, the cis-fused D and E rings was formed by a Diels-Alder reaction. Intramolecular Diels-Alder of the ...
Syrosingopine
... is a drug, derived from reserpine. It is used (since about 1960) to treat hypertension. A combination of the ... "Comparison of syrosingopine and reserpine in the treatment of ambulatory hypertensive patients". The American Journal of the ...
Tranquilizer
Reserpine is a centrally acting Rauwolfia alkaloid. The word directly refers to the state of tranquillity in a person and other ... from the conclusions of investigative studies using the drug reserpine, which showed the drug had a calming effect on all ...
Bietaserpine
... (INN), or 1-[2-(diethylamino)ethyl]reserpine, is a derivative of reserpine used as an antihypertensive agent. Like ... reserpine, bietaserpine is a VMAT inhibitor. Buckingham J et al. (eds.) (1993). Dictionary of Natural Products, vol. 5, p. 4923 ...
Methoserpidine
... is an antihypertensive drug related to reserpine. Jones, D. L.; Michael, A. M.; Ommer, J. P. (1961). "Clinical ...
Indole alkaloid
Reserpine was the second (after chlorpromazine) antipsychotic drug; however, it showed relatively weak action and strong side ... Rauvolfia serpentina, which contains reserpine as the active substance, was used for over 3000 years in India to treat snake ... The flowering plant Rauvolfia serpentina which contains reserpine was a common medicine in India around 1000 BC. Africans used ... So, harmine and harmaline are reversible selective inhibitors of monoamine oxidase-A. Reserpine reduces concentration of ...
D-CON
Adrian P. Meehan (December 1980). "The rodenticidal activity of reserpine and related compounds". Pesticide Science. 11 (6): ...
Rauvolfia vomitoria
In the 1970s, the bark from stems and roots was harvested from which reserpine was extracted and sold for human use. Reserpine ... The plant contains a number of chemical compounds used by the pharmaceutical industry; these include reserpine, reserpinine, ...
Rauvolfia serpentina
Reserpine List of herbs with known adverse effects Wikimedia Commons has media related to Rauvolfia serpentina. "Appendices". ... Rabbits fed a high-cholesterol diet who took reserpine for 6 weeks had their total cholesterol levels reduced by 42% and their ... The reserpine in R. serpentina is associated with diverse adverse effects, including vomiting, diarrhea, dizziness, headache, ... According to a 2016 review by Canadian researchers, 4 different high-quality clinical trials on humans suggest that reserpine ...
Antidepressant
Although in 1955 reserpine was shown to be more effective than placebo in alleviating anxious depression, neuroleptics were ... In addition to this review, a 2003 literature review and a 2022 systematic review, both of reserpine and mood, found that in ... Strawbridge R, Javed RR, Cave J, Jauhar S, Young AH (August 2022). "The effects of reserpine on depression: A systematic review ... Instead, the results were highly mixed, with similar proportions of studies finding that reserpine had no influence on mood, ...
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4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists". Nature. 180 (4596): 1200. Bibcode:1957Natur. ...
Marthe Vogt
Muscholl, Erich; Vogt, Marthe (1958). "The action of reserpine on the peripheral sympathetic system". Journal of Physiology. ... publishing research on serotonin and reserpine. In 1948, Vogt published a seminal work with William Feldberg: "Acetylcholine ...
Vesicular monoamine transporter 1
Erickson JD, Eiden LE, Hoffman BJ (November 1992). "Expression cloning of a reserpine-sensitive vesicular monoamine transporter ... Several reuptake inhibitors of VMATs are known to exist, including reserpine (RES), tetrabenazine (TBZ), dihydrotetrabenazine ( ...
Quinone
Historically important syntheses include cholesterol, cortisone, morphine, and reserpine. A large scale industrial application ...
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He pioneered the use of reserpine to control hypertension. Reserpine is derived from Indian Snakeroot, Rauwolfia serpentina, ...
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He then showed that giving animals the drug reserpine caused a decrease in dopamine levels and a loss of movement control. ... 4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists". Nature. 180 (4596): 1200. Bibcode:1957Natur. ...
Tramadol
Reimann W, Schneider F (May 1998). "Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine". European ...
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Analgesic
Reimann W, Schneider F (May 1998). "Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine". European ...
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Further testing was able to reveal that reserpine causes a depletion of monoamine concentrations in the brain. Reserpine's ... When reserpine (an alkaloid with uses in the treatment of hypertension and psychosis) was first introduced to the West from ... This was based on similar evidence to that which produced the NA theory as reserpine, imipramine, and iproniazid affect the 5- ... Tetrabenazine, a similar agent to reserpine, which also depletes catecholamine stores, and to a lesser degree 5-HT, was shown ...
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Erowid.org: Erowid Reference 1956 : Blockade of reserpine emesis in pigeons : Gupta GP, Dhawan BN
Dhawan BN Blockade of reserpine emesis in pigeons Arch. int. pharmacodyn. 1960 128:481-490 ... Various pharmacological agents were tested for their ability to block reserpine-induced (0.5 mg/kg) emesis in pigeons. . Among ... Results of LSD in various doses with simultaneous reserpine challenge were: . Among the central nervous depressants studied ... According to the literature, most of the effective drugs antagonize other effects of reserpine. ...
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An quantitative analysis example of reserpine by using Hitachi Chromaster 5610 MS detector. ... This time, reserpine was quantitatively analyzed as a model sample. Reserpine is a component analyzed as a standard sample by ... Analysis of Reserpine by Mass Detector. Note Number: AS/MSD-005. Chromaster 5610 MS Detector is a mass detector with new ...
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The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following ... Palfai, T., Wichlinski, L., Alex Brown, H., & Brown, O. M. (1986). Effects of amnesic doses of reserpine or syrosingopine on ... Palfai, T, Wichlinski, L, Alex Brown, H & Brown, OM 1986, Effects of amnesic doses of reserpine or syrosingopine on mouse ... Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels. In: Pharmacology, Biochemistry and ...
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Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model | Phoenix Rising ME...
Chorea in Adults Medication: Antipsychotic agents, Monoamine depleting agents, Benzodiazepines, Anticonvulsants
Reserpine Archives - Medicine Port
IMSEAR at SEARO: Interactions between reserpine and anticonvulsants on convulsion parameters.
Reserpine lowered the MET and this lowering of MET was antagonized by chloridaze-poxide but not by acetazoleamide and phenytoin ... High doses of reserpine abolished flexion component and this was restored by propranolol, phenytoin, atropine, chlordiazepoxide ... With increasing doses of reserpine the extension time in an MES test was increased and this was antagonized by all ... Interactions between reserpine and anticonvulsants on convulsion parameters. Indian Journal of Physiology and Pharmacology. ...
DailyMed - PROPRANOLOL HYDROCHLORIDE capsule, extended release
Synthesis of Reserpine by Robert B. Woodward (1956)
Erowid.org: References Database
Therapeutic potential of Reserpine in metabolic syndrome. | Pharmacol Res;190: 106719, 2023 04. | MEDLINE
VMAT2 Products: R&D Systems
Side Effects of Dilantin (phenytoin): Interactions & Warnings
Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria | Dhanarani | Chemical Biology...
Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria ... The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and ... from poultry litter were evaluated. Reserpine increased the activity of antibiotics against bacteria and directly blocks the ... Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria. ...
Docking of Three Oral Carcinoma Targets with Reserpine
| Annals of the Romanian Society for Cell Biology
Reserpine is a drug that is used for the treatment of high blood pressure and for relief of psychotic symptoms. Reserpine is ... Results show that Reserpine inhibits BCL-2 with the highest GOLD score of 68.4 when compared to the other targets. Hydrogen ... Joshini Shanmugam, Lakshmi T. (2021). Docking of Three Oral Carcinoma Targets with Reserpine. Annals of the Romanian Society ... Since docking is high in reserpine with bcl-2, In-vitro study can be carried out and further binding capacity can be studied. ...
Tranylcypromine (Oral Route) Precautions - Mayo Clinic
Deutetrabenazine Monograph for Professionals - Drugs.com
Wait for signs of chorea or dyskinesia to reemerge after discontinuing reserpine before initiating deutetrabenazine therapy ... Allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine ... allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine. (See Specific Drugs ...
The Poisonous Chemistry of Chocolate | WIRED
Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain - Volume 15, Number 6...
Mutations in the QRDRs of parC, parE, and gyrA were identified, and the presence of reserpine-sensitive fluoroquinolone efflux ... Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single ... One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was ... Four isolates had a reserpine efflux phenotype. The fifth isolate may have had a different efflux inhibitor or an unknown ...
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression...
Reserpine caused a decrease in the time spent in motor and swimming activity besides increasing the time of immobility, as ... and striatum of reserpine-treated rats. Free GA was more effective in increasing the serotonin level in the cortex, hippocampus ... antidepressant efficacy in a rat model of depression caused by reserpine. By using a scanning electron microscope (SEM), ... Effect of i.p. injection of reserpine, free GA, free MSNps, GA-loaded MSNPs on the Acetylcholine esterase (AChE) levels in ...
Alpha-lipoic acid-role in improving both reserpine toxicity and paroxetine treatment in the cerebral cortex of albino rats;...
... mg/kg of reserpine once daily for consecutive 14 day. Then these animals were divided into; Group III (reserpine group) ... Group IV; reserpine-treated animals were treated with paroxetine (20 mg/kg) daily for 6 weeks. Group V, animals in ... Reserpine-treated rats showed disorganized layers of cerebral cortex with degenerative, apoptotic and necrotic changes. ... After paroxetine-treatment these parameters were more or less similar to those observed in reserpine-treated ones. While an ...
Bisoprolol - Health Library
Jamp-Cetirizine - Uses, Side Effects, Interactions - MedBroadcast.com
Jamp-Cetirizine: Cetirizine belongs to the class of medications called second-generation antihistamines, specifically the class known as histamine receptor antagonists. For adults and children 2 years of age and older, it is used for the relief of symptoms associated with seasonal allergies including sneezing; itchy nose and throat; stuffy and runny nose; and tearing, red, or itchy eyes. It is also used for the relief of symptoms associated with allergic skin conditions (e.g., chronic idiopathic urticaria) such as itchy skin and hives. For adults and children over the age of 12 years, it is also used for the relief of symptoms associated with year-round allergies and hives.
Alkaloid3
- Reserpine is an alkaloid from the roots of Rauwofia serpentina (sarpgandha) indigenous to India which has been used in 'Ayurvedic' medicine for centuries. (medicineport.com)
- Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment. The role of efflux pump inhibitor, reserpine â€" a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp. (iscience.in)
- Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. (rxlist.com)
Doses4
- Older adults should not usually take high doses of reserpine because it is not as safe as other medications that can be used to treat the same condition. (medlineplus.gov)
- With increasing doses of reserpine the extension time in an MES test was increased and this was antagonized by all anticonvulsants tested namely acetazolamide, chlordiazepoxide, phenytoin and propranolol. (who.int)
- High doses of reserpine abolished flexion component and this was restored by propranolol, phenytoin, atropine, chlordiazepoxide and acetazolamide. (who.int)
- Effects in man of single and combined oral doses of reserpine, ipronia. (erowid.org)
Chlorpromazine and Reserpine1
- It has also been reported to enhance the sedative activity of barbituates, alcohol, chlorpromazine and reserpine. (centerwatch.com)
Snakeroot1
- First isolated from the root of Rauwolfia Serpentina (Indian Snakeroot), reserpine was FDA approved in 1955. (medscape.com)
Norepinephrine3
- Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. (fpnotebook.com)
- Reserpine depletes norepinephrine and epinephrine. (medscape.com)
- Reserpine irreversibly blocks the Vesicular Monoamine Transporters- VMAT 1 and 2 reducing the stores of the monoamines (norepinephrine, dopamine, serotonin). (medscape.com)
Alkaloids1
- Reserpine is in a class of medications called rauwolfia alkaloids. (medlineplus.gov)
Rauwolfia1
- Alcaloide que se encuentra en las raÃces de Rauwolfia serpentina y R. vomitoria. (bvsalud.org)
19551
- which weight loss suppressant to bring Giessen Hospital back to life temporarily As ketoscience real ketones powder dietary supplement future will look like, neither Lutz nor Marko extenze dietary supplement ht.Although in 1955 reserpine was shown to be more effective than placebo in alleviating anxious depression, neuroleptics were being developed as and. (salongm.se)
Inhibits1
- Results show that Reserpine inhibits BCL-2 with the highest GOLD score of 68.4 when compared to the other targets. (annalsofrscb.ro)
Monoamine2
- Reserpine is a monoamine depletory drug cause oxidative damage and used to induce depression-like features in rodent model. (springeropen.com)
- Reserpine is a monoamine depletory drug that blocks vesicular monoamine transporters during neuronal transmission and storage, as well as promotes dopamine autoxidation and oxidative catabolism through monoamine oxidase, causing oxidative stress [ 1 ]. (springeropen.com)
Drugs2
- According to the literature, most of the effective drugs antagonize other effects of reserpine. (erowid.org)
- the drugs such as reserpine decrease the concentrations of monoamines in the central nervous system (CNS), and used as pharmacological model for depressive-like behavior induced in rodents [ 2 , 3 ]. (springeropen.com)
Efflux4
- Low-level resistance (30 isolates with MIC 4-8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV ( parC [n = 24] or parE [n = 1]) changes. (cdc.gov)
- One isolate did not show reserpine-sensitive efflux or mutations. (cdc.gov)
- Mutations in the QRDRs of parC , parE , and gyrA were identified, and the presence of reserpine-sensitive fluoroquinolone efflux was determined. (cdc.gov)
- Resistance to fluoroquinolones in S . pneu- with MIC 4-8 µg/mL) was caused by a reserpine-sensitive moniae can be acquired by point mutations, intraspecific efflux phenotype (n = 4) or single topoisomerase IV ( parC [n = 24] or parE [n = 1]) changes. (cdc.gov)
Alcohol2
- ask your doctor about the safe use of alcohol while you are taking reserpine. (medlineplus.gov)
- Alcohol can make the side effects from reserpine worse. (medlineplus.gov)
Interactions1
- IMSEAR at SEARO: Interactions between reserpine and anticonvulsants on convulsion parameters. (who.int)
Symptoms2
- Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (medlineplus.gov)
- Reserpine is a drug that is used for the treatment of high blood pressure and for relief of psychotic symptoms. (annalsofrscb.ro)
Rats3
- Reserpine-treated rats showed disorganized layers of cerebral cortex with degenerative, apoptotic and necrotic changes. (springeropen.com)
- ALA treatment attenuated the cerebral injury induced by reserpine and improved the effects of paroxetine in rats due to its anti-inflammatory, anti-apoptotic and antioxidant activities. (springeropen.com)
- Saliva from reserpine treated rats causes ciliary inhibition similar to that induced by CF serum. (cdc.gov)
Intraperitoneally2
- Reserpine (2 mg/kg for 10 days, intraperitoneally) induced depression, pain, and fatigue behaviors in mice. (phoenixrising.me)
- The induction of depression-like features occurred when the rest of animals were intraperitoneally treated with 25 mg/kg of reserpine once daily for consecutive 14 day. (springeropen.com)
Medications2
- tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (medlineplus.gov)
- This study found that white blood cell counts, assessed weekly, were notably lower in cycles where women were treated with thiazide diuretics versus cycles where the same women were treated with other blood pressure medications (reserpine or propanolol), raising concerns that thiazide diuretics may enhance the myelosuppressive effects of chemotherapy. (cdc.gov)
Effects5
- If you suddenly stop taking reserpine you may develop high blood pressure and experience unwanted side effects. (medlineplus.gov)
- Reserpine may cause side effects. (medlineplus.gov)
- The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. (syr.edu)
- The results suggest that whole brain acetyylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine. (syr.edu)
- Reserpine once was used in their side effects, they are wipes instead of toilet paper. (penatelukcenderawasih.net)
Peripheral1
- Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of shorter duration. (rxlist.com)
Blood pressure1
- Reserpine is used to treat high blood pressure. (medlineplus.gov)
Tablet1
- Reserpine comes as a tablet to take by mouth. (medlineplus.gov)
Search1
- These images are a random sampling from a Bing search on the term "Reserpine. (fpnotebook.com)
Time2
- Take reserpine at around the same time every day. (medlineplus.gov)
- This time, reserpine was quantitatively analyzed as a model sample. (hitachi-hightech.com)
Block1
- Various pharmacological agents were tested for their ability to block reserpine-induced (0.5 mg/kg) emesis in pigeons. (erowid.org)
Weeks1
- reserpine-treated animals were treated with paroxetine (20 mg/kg) daily for 6 weeks. (springeropen.com)
Component1
- Reserpine is a component analyzed as a standard sample by LC-MS. The calibration curve generated based on the SIM chromatograms showed a good linearity. (hitachi-hightech.com)
Potential1
- Therapeutic potential of Reserpine in metabolic syndrome. (bvsalud.org)
Treatment3
- If you are currently taking reserpine, you should call your doctor to discuss switching to another treatment. (medlineplus.gov)
- The present study was aimed to elucidate the possible protective effect of ALA in the improvement of the deleterious cerebral cortex injury after reserpine and paroxetine treatment. (springeropen.com)
- After paroxetine-treatment these parameters were more or less similar to those observed in reserpine-treated ones. (springeropen.com)
Group1
- Group III (reserpine group) animals in this group were sacrificed on 15th day. (springeropen.com)
Days1
- in addition, allow at least 20 days to elapse between discontinuance of reserpine and initiation of deutetrabenazine. (drugs.com)
Article2
- Le présent article est le premier de trois articles de synthèse qui constituent le contexte de recherche d'une série de cinq études interdépendantes sur les modes de prescription et les erreurs de médication dans les secteurs public et privé des soins de santé primaires en Arabie saoudite. (who.int)
- Le présent article analyse les variations dans les modes de prescription et les facteurs influençant le comportement prescripteur des médecins dans le monde et en Arabie saoudite. (who.int)