Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Kidney Transplantation: The transference of a kidney from one human or animal to another.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Kidney Tubules: Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.Glomerular Filtration Rate: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.Kidney Function Tests: Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.Kidney Cortex: The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.CreatininePolycystic Kidney Diseases: Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Kidney Tubules, Proximal: The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Polycystic Kidney, Autosomal Dominant: Kidney disorders with autosomal dominant inheritance and characterized by multiple CYSTS in both KIDNEYS with progressive deterioration of renal function.Kidney Diseases, Cystic: A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).Renal Replacement Therapy: Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.Nephritis: Inflammation of any part of the KIDNEY.Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Kidney Medulla: The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Lupus Nephritis: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.AIDS-Associated Nephropathy: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Nephrectomy: Excision of kidney.Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Nephrosclerosis: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.Peritoneal Dialysis: Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Glomerulonephritis, IGA: A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.Kidney Tubules, Collecting: Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Nephrons: The functional units of the kidney, consisting of the glomerulus and the attached tubule.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Podocytes: Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Peritoneal Dialysis, Continuous Ambulatory: Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Kidneys, Artificial: Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.Blood Urea Nitrogen: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Cystatin C: An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Glomerulonephritis, Membranoproliferative: Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Kidney Tubules, Distal: The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Renal Circulation: The circulation of the BLOOD through the vessels of the KIDNEY.Kidney Concentrating Ability: The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Glomerular Mesangium: The thin membranous structure supporting the adjoining glomerular capillaries. It is composed of GLOMERULAR MESANGIAL CELLS and their EXTRACELLULAR MATRIX.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Glomerulonephritis, Membranous: A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Kidney Tubular Necrosis, Acute: Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Hematuria: Presence of blood in the urine.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.United StatesRisk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Glomerular Basement Membrane: The layer of EXTRACELLULAR MATRIX that lies between the ENDOTHELIUM of the glomerular capillaries and the PODOCYTES of the inner or visceral layer of the BOWMAN CAPSULE. It is the product of these two cell types. It acts as a physical barrier and an ion-selective filter.Ureter: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.Kidney Cortex Necrosis: Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.TRPP Cation Channels: A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Pyelonephritis: Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.Polycystic Kidney, Autosomal Recessive: A genetic disorder with autosomal recessive inheritance, characterized by multiple CYSTS in both KIDNEYS and associated LIVER lesions. Serious manifestations are usually present at BIRTH with high PERINATAL MORTALITY.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Nephritis, Hereditary: A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Mesangial Cells: Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.Arteriovenous Shunt, Surgical: Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Mice, Inbred NZBCell Line: Established cell cultures that have the potential to propagate indefinitely.Calcinosis: Pathologic deposition of calcium salts in tissues.Nephrosis: Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Uromodulin: A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Hyperparathyroidism, Secondary: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Waiting Lists: Prospective patient listings for appointments or treatments.Hydronephrosis: Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.Urinalysis: Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Diabetes Complications: Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Mice, Inbred MRL lpr: A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Mice, Inbred C57BLTissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Hemodialysis, Home: Long-term maintenance hemodialysis in the home.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Organ Size: The measurement of an organ in volume, mass, or heaviness.Indican: A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.African Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Africa.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Renal Artery Obstruction: Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).Multicystic Dysplastic Kidney: A nongenetic defect due to malformation of the KIDNEY which appears as a bunch of grapes with multiple renal cysts but lacking the normal renal bean shape, and the collection drainage system. This condition can be detected in-utero with ULTRASONOGRAPHY.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 188.8.131.52.Transforming Growth Factor beta1: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.Nephrolithiasis: Formation of stones in the KIDNEY.Cadaver: A dead body, usually a human body.Phosphates: Inorganic salts of phosphoric acid.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Hemodialysis Units, Hospital: Hospital units in which care is provided the hemodialysis patient. This includes hemodialysis centers in hospitals.Renal Osteodystrophy: Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.alpha-2-HS-Glycoprotein: A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Hemolytic-Uremic Syndrome: A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.Radioisotope Renography: Graphic tracing over a time period of radioactivity measured externally over the kidneys following intravenous injection of a radionuclide which is taken up and excreted by the kidneys.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Mycophenolic Acid: An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Cystatins: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.Hematinics: Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Indians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Immune Complex Diseases: Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Fabry Disease: An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.Complement C3: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.Peptidyl-Dipeptidase A: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 184.108.40.206.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Inulin: A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Directed Tissue Donation: Tissue, organ, or gamete donation intended for a designated recipient.
Dal Canton, A. (1995). Adhesion molecules in renal disease. Kidney International, 48, 1687-1696.] [ Weber, M., Hauschild, R., ... Idiopathic pulmonary fibrosis (IPF) is a disease marked by fibrosis in lung mesothelial cells. TGF-β1 is a cytokine found in ... Haptotaxis plays a role in several kinds of diseases where the movement or aggregation of cells causes the symptoms. As ... The introduction of haptotactic peptides may help in healing several diseases such as diabetes mellitus, hemophilia A and B ...
"Endothelial function in proteinuric renal disease". Kidney International. 56: S57-S61. doi:10.1046/j.1523-1755.1999.07115.x. " ... Moreover, LPCs can be used in the lab to cause demyelination of brain slices, to mimic the effects of demyelinating diseases ... More is discussed below concerning possible diseases related to excessive intake of lysophosphatidylcholine. If one has ... miltefosine and perifosine are under research and development as drugs against cancer and other diseases. ...
Renal:An integrated approach to disease. McGraw Hill, New York NY 2012, pg 123 Rademaker-Lakhai JM, Crul M, Zuur L, et al. ( ... October 1987). "Comparison of loop diuretics in patients with chronic renal insufficiency". Kidney International. 32 (4): 572-8 ... The time frames for progress of the disease vary greatly and symptoms of hearing loss may be temporary or permanent. The ... Such treatments are typically taken to comfort the patient, not to cure the disease or damage caused by ototoxicity. There is ...
Surgical clinic of renal disease). Berlin 1901. Die Chirurgie der Niere und des Harnleiters. (The surgery of the kidney and ... His inaugural thesis involved Bright's kidney disease, and his first report of an operation of the kidney was in 1882. He ... Centers for Disease Control and Prevention Actinomyces Odontolyticus Bacteremia J.P. Euzéby: List of Prokaryotic names with ... Among his students in Berlin was surgeon Ferdinand Karewski (1858-1923). Israel was a pioneer in modern urologic and renal ...
Symptom targeted intervention
"Depression and end-stage renal disease: A therapeutic challenge". Kidney International. 74 (7): 843-5. doi:10.1038/ki.2008.222 ... McCool originally developed STI for patients with end-stage renal disease (ESRD). Patients with ESRD and other chronic diseases ... Cardiovascular Disease Events, and Mortality in End-Stage Renal Disease: Contribution of Reverse Causality". Clinical Journal ... Kimmel, Paul L (2002). "Depression in patients with chronic renal disease". Journal of Psychosomatic Research. 53 (4): 951-6. ...
"Identification, management and referral of adults with chronic kidney disease: concise guidelines" (PDF). UK Renal Association ... Proteinuria may be a sign of renal (kidney) damage. Since serum proteins are readily reabsorbed from urine, the presence of ... The 2005 UK Chronic Kidney Disease guidelines state that protein/creatinine ratio is a better test than 24-hour urinary protein ... Glomerular diseases, such as membranous glomerulonephritis, focal segmental glomerulonephritis, minimal change disease (lipoid ...
William Richard Basham
... liver disease). Severe renal impairment (kidney disease). Cardiac disease. Domperidone is a peripherally selective dopamine D2 ... Parkinson's disease is a chronic neurological condition where a decrease in dopamine in the brain leads to rigidity (stiffness ... In Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper ... Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease; it blocks peripheral D2 receptors but does ...
Kidney disease and also affections of the renal pelvis and mesonephros. "Traumatische Leukämie," in "Deutsche Med. ... 1902 - On diseases experienced on a campaign to Russia. "Dorf- und Stadthygiene," ib. 1902 - Village and city hygiene. "Die ... Circulation Congenital Heart Disease for the Adult Cardiologist Medical Dictionary Pel-Ebstein fever. ... a remittent fever associated with Hodgkin's disease). Pagel, J. L., Biographisches Lexikon, s.v. Meyers Konversations-Lexikon, ...
"Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease". Kidney ... MYH9-related disease. Mutations in MYH9 cause a Mendelian autosomal-dominant disorder known as MYH9-related disease (MYH9-RD).[ ... Genetic variations in MYH9 may be involved in predisposition to chronic kidney disease (CKD). A haplotype of MYH9 (haplotype E1 ... "The MYH9/APOL1 region and chronic kidney disease in European-Americans". Human Molecular Genetics. 20 (12): 2450-6. doi:10.1093 ...
Manuel Martínez Maldonado
His clinical research has included polycycstic kidney disease, renal stones and hypercalcemia. Martinez-Maldonado has occupied ... Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney. ... Martínez Maldonado became interested in the field of renal physiology and, later on, in nephrology, and was accepted by the ... He completed his postdoctoral study on renal and electrolyte metabolism at the Southwestern Medical School of the University of ...
Duffy antigen system
"Up-regulation of Duffy antigen receptor expression in children with renal disease". Kidney Int. 55 (4): 1491-500. doi:10.1046/j ... "Expression of chemokines and chemokine receptors during human renal transplant rejection". Am. J. Kidney Dis. 37 (3): 518-31. ... Hemolytic disease of the fetus and newborn is typically mild but rarely may be serious. Almost always due to anti-Fya and ... However once established, the absence of the DARC receptor appears to slow down the progression of the disease. HIV-1 appears ...
Individuals with pre-renal kidney failure do not have damage to the kidneys, but as in individuals with HRS, have kidney ... the absence of kidney disease or obstruction of kidney outflow as seen on ultrasound. The minor criteria are the following: a ... Many other diseases of the kidney are associated with liver disease and must be excluded before making a diagnosis of ... of the kidney circulation and worsening kidney vasoconstriction, leading to kidney failure. Studies to quantify this theory ...
Persons with this disease may have hypoplasic kidneys or proteinuria. This disease was first described in a Caucasian family of ... Branchio-oto-renal syndrome sciencedirect[dead link] Lachiewicz AM, Sibley R, Michael AF (June 1985). "Hereditary renal disease ... Lachiewicz-Sibley syndrome is a rare autosomal dominant disorder characterized by preauricular pits and renal disease. ... Unlike branchio-oto-renal (BOR) syndrome, Lachiewicz-Sibley syndrome is characterized by only preauricular pitting and renal ...
Raul M. Gonzalez
"Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease". Kidney Int. 75 (9): 976-81. doi ... There are many diseases where failure to adequately absorb iron contributes to iron deficiency and iron deficiency anaemia. The ... such as renal failure. Any one of several mutations in hepcidin result in juvenile hemochromatosis. The majority of juvenile ... and kidneys markedly increases. The overload of iron is associated with low levels of hepcidin. Patients with β-thalassemia ...
Your Kidneys and How They Work - (American) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH. ... Hemodialysis is one of three renal replacement therapies (the other two being kidney transplant and peritoneal dialysis). An ... Treatment Methods for Kidney Failure - (American) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH ... Treatment Methods for Kidney Failure: Hemodialysis - (American) National Kidney and Urologic Diseases Information Clearinghouse ...
Intravascular volume status
Renal causes include overuse of diuretics, or trauma or disease of the kidney. Extrarenal causes include bleeding, burns, and ... It can also occur if there is inadequate urination, e.g. with certain kidney diseases. MedicineNet > Definition of Hypovolemia ... The other causes are usually divided into renal and extrarenal causes. ...
When added to any additional renal disease, it may cause permanent kidney damage. As is apparent from the list below, many high ... ISBN 1-4160-2328-3. Kalantar-Zadeh K, Fouque D (Nov 2, 2017). "Nutritional management of chronic kidney disease". N. Engl. J. ... of Medicine suggests that high protein diet may contribute to life-long risk of kidney damage including chronic kidney disease ... Increased load on the kidney is a result of an increase in reabsorption of NaCl. This causes a decrease in the sensitivity of ...
... a disease shown to be a model for Alport syndrome. Fechtner syndrome Diseases of the Kidney: Alport Syndrome "Alport syndrome" ... Renal Rare Diseases Registry. Retrieved 17 February 2016. Zhou, Jing; Hertz, Jens Michael; Tryggvason, Karl (1992). "Mutation ... To be helpful, kidney biopsies need to be taken before the disease is too advanced. Changes on conventional (light) microscopy ... In addition to measures for chronic kidney disease (CKD) of any cause, there is evidence that ACE inhibitors can slow the ...
"Serum magnesium level and arterial calcification in end-stage renal disease". Kidney Int. 32: 388-394. doi:10.1038/ki.1987.222 ... renal disease suggest that hypermagnesemia may retard the development of arterial calcifications in end-stage renal disease. ... Massy ZA, Drüeke TB (2012). "Magnesium and outcomes in patients with chronic kidney disease: focus on vascular calcification, ... were observed in chronic kidney disease patients with high serum magnesium levels (0.90-1.32 mmol/L or 2.18-3.21 mg/dL) ...
It may also occur because of some severe obstruction like kidney stones or tumours. It may occur with end stage renal disease. ... Acute renal failure can be caused by factors not related to the kidney, such as heart failure, mercury poisoning, infection, ... Anuria itself is a symptom, not a disease. It is often associated with other symptoms of kidney failure, such as lack of ... However, mannitol is contraindicated in anuria secondary to renal disease, severe dehydration, intracranial bleeding (except ...
Tanner, G.A. "Potassium citrate improves renal function in rats with polycystic kidney disease". Journal of the American ... Medicinally, it may be used to control kidney stones derived from either uric acid or cystine. Potassium citrate is produced by ... It is widely used to treat urinary calculi (kidney stones) and is often used by patients with cystinuria.[medical citation ... Environmental Health & Safety MSDS Number:P5675 Medscape on hypocitraturia Potassium Citrate for Kidney Stones Potassium ...
"Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease". American Journal of ... Dysregulation of TGF-B/Smad signaling is a possible pathogenic mechanism of chronic kidney disease. In the kidneys, TGF-B1 ... Böttinger EP, Bitzer M (October 2002). "TGF-beta signaling in renal disease". Journal of the American Society of Nephrology. 13 ... Eddy AA, Neilson EG (November 2006). "Chronic kidney disease progression". Journal of the American Society of Nephrology. 17 ( ...
Those with atherosclerotic renal artery disease have a high risk of mortality, furthermore those who also have renal ... Renovascular hypertension (or "renal hypertension") is a condition in which high blood pressure is caused by the kidneys' ... Fibromuscular dysplasia Hypertensive nephropathy Kidney failure Renal artery stenosis MedlinePlus Encyclopedia Renovascular ... renal artery stenosis). As a consequence of this action the renal organs release hormones that indicate to the body to maintain ...
Induced stem cells
The generation of such cells may lead to cellular therapies for adult renal disease. Embryonic kidney organoids placed into ... Chronic lung diseases such as idiopathic pulmonary fibrosis and cystic fibrosis or chronic obstructive pulmonary disease and ... Stroke and many neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis ... Diseases that attack myelin, such as multiple sclerosis, result in nerve signals that cannot propagate to nerve endings and as ...
Type 2 diabetes
"National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 6 March 2016. ... should receive an inhibitor of the renin-angiotensin system to reduce the risks of progression to end-stage renal disease, ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... "National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 2 February 2016. ...
Renal abnormalities, sterile leukocyturia, and reduced creatinine clearance.. *Impairs endothelial function in healthy HIV- ... Nephrolithiasis/urolithiasis (the formation of kidney stones), which sometimes may lead to more severe condition including ... It significantly increased life expectancies and decreased noticeable symptoms from infectious diseases that were the result of ... it is no longer recommended to use in the United States for initial treatments due to pill burden and risk of kidney stones. ...
"Iran J Kidney Dis. 7 (6): 492-95. PMID 24241097.. *^ Del Prete, A; Scalera, A; Iadevaia, M. D.; Miranda, A; Zulli, C; Gaeta, L ... while imbalance results in disease. Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, ... Specific groups of patients such as patients with impaired hepatic or renal function are more susceptible to side effects of ... A belief that a substance that causes the symptoms of a disease in healthy people cures similar symptoms in sick people.[n 8] ...
Saint Barnabas Medical Center
... the 3rd highest score in New Jersey for Kidney disease; and the 4th highest score in New Jersey for Cancer, Gynecology, and ... The Renal and Pancreas Transplant Division at Saint Barnabas Medical Center and Newark Beth Israel Medical Center combined is ... Over time, it has performed many kidney transplants and exchanges including complex multihospital kidney exchanges. The ... 2009 New Robot Technology Eases Kidney Transplants, CBS News, June 22, 2009 - accessed July 8, 2009 Kidney donations connect ...
... and IgG4-related disease. There is some evidence that it is ineffective in treating IgA-mediated autoimmune diseases. ... Rituximab is being used off-label in the management of kidney transplant recipients. This drug may have some utility in ... Tumor lysis syndrome, causing acute renal failure. *Infections *Hepatitis B reactivation. *Other viral infections ... Autoimmune diseases. Rituximab has been shown to be an effective rheumatoid arthritis treatment in three randomised ...
... and IgG4-related disease. There is some evidence that it is ineffective in treating IgA-mediated autoimmune diseases. ... Rituximab is being used off-label in the management of kidney transplant recipients. This drug may have some utility in ... Tumor lysis syndrome, causing acute renal failure. *Infections *Hepatitis B reactivation. *Other viral infections ... "Annals of the Rheumatic Diseases. 62 (90002): 55ii-59. doi:10.1136/ard.62.suppl_2.ii55. PMC 1766758. PMID 14532151.. ...
Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... Before reaching the branchial heart, each branch of the vena cava expands to form renal appendages which are in direct contact ... The octopus has two nephridia (equivalent to vertebrate kidneys) which are associated with the branchial hearts; these and ... The diseases and parasites that affect octopuses have been little studied, but cephalopods are known to be the intermediate or ...
"Pax genes in renal development, disease and regeneration". Seminars in Cell & Developmental Biology. Paramutation & Pax ... kidney epithelium development. • regulation of transcription, DNA-templated. • positive regulation of metanephric DCT cell ... kidney development. • pronephric field specification. • positive regulation of mesenchymal to epithelial transition involved in ... Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is ...
... juvenile renal disease, hip dysplasia, and cancer. Standard Poodles are also susceptible to some health issues usually too ... near the kidneys). Addison's is often undiagnosed because early symptoms are vague and easily mistaken for other conditions. ... Addison's disease. Addison's disease is (as of 20 August 2007) the illness most commonly reported to the Poodle Health Registry ... The number of reported cases is nearly twice as high as the next most common problem (GDV). Addison's disease is characterized ...
... such as diabetes and autoimmune disease; and systemic diseases that occur as a result of kidney disease, such as renal ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... and the Renal Association represents renal physicians and works closely with the National Service Framework for kidney disease ...
ادرار کردن - ویکیپدیا، دانشنامهٔ آزاد
"Preventing kidney infection". nhs.uk. National Health Service. 11 December 2012. Retrieved 22 September 2014.. ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ... can cause renal damage in women. Female urination devices are available to help women to urinate discreetly, as well to ... A drug that increases urination is called a diuretic, whereas antidiuretics decrease the production of urine by the kidneys. ...
നെഫ്രോട്ടിക് സിൻഡ്രോം - വിക്കിപീഡിയ
肥胖症 - 维基百科，自由的百科全书
A.M.A. Recognizes Obesity as a Disease. New York Times. 2013-06-18 [2015-11-19]. （原始内容存档于2013-06-23）.. ... Diet Drug Orlistat Linked to Kidney, Pancreas Injuries. Medscape. Medscape News. [2011-04-26]. （原始内容存档于2012-05-10）.. ... Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyrén O. Obesity and risk for chronic renal failure. J. Am. Soc. ... Centers for Disease Control and Prevention. 2007-05-22 [2007-09-05]. （原始内容存
A large part of this difficulty is due to a lack of ability to predict which people will progress to end-stage kidney disease, ... "Renal Pathology". Retrieved 2008-11-25.. *^ Obana M, Nakanishi K, Sako M, Yata N, Nozu K, Tanaka R, Iijima K, Yoshikawa N (July ... Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 ... or kidney disease severe enough to require dialysis. Because the above medications carry risk, treatment should not be ...
While not present at birth, many affected boys develop kidney problems at about one year of age. Renal pathology is ... the disease develops mostly in men with very rare occurrences in women, while women are carriers of the disease; it has an ... "Lowe's (Oculo-Cerebro-Renal) Syndrome , Doctor , Patient". Patient. Retrieved 21 December 2016. RESERVED, INSERM US14 -- ALL ... Because of the three major organ systems involved (eyes, brain, and kidney), it is also known as oculocerebrorenal syndrome. ...
... and certain kidney diseases. Some diuretics, such as acetazolamide, help to make the urine more alkaline and are helpful in ... This is large in comparison to normal renal sodium reabsorption which leaves only about 0.4% of filtered sodium in the urine. ... antagonism leads to decreased number of aquaporin channels in the apical membrane of the renal collecting ducts in kidneys, ... This causes an increase in renal free water excretion (aquaresis), an increase in serum sodium concentration, a decrease in ...
The renal effect of fenoldopam and dopamine may involve physiological antagonism of the renin-angiotensin system in the kidney. ... in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease. ... including renal, mesenteric, and coronary arteries. to cause a reduction in systemic vascular resistance. Fenoldopam has a ... Since fenoldopam is the only intravenous agent that improves renal perfusion, ...
Granulomatosis with polyangiitis
... renal vasculitis) reduces progression to end-stage kidney disease at three months. ... Kidney: rapidly progressive glomerulonephritis (75%), leading to chronic kidney failure. *Upper airway, eye and ear disease: * ... Limited diseaseEdit. In generalised non-organ-threatening disease, remission can be achieved with a combination of methotrexate ... An early name for the disease was pathergic granulomatosis. The disease is still sometimes confused with lethal midline ...
Hepatit - Vikipedi
Bondarenko VI, Zadorozhnaia VI (March 1992). "[The role of enteroviruses in the etiology of diseases of the pancreas, kidneys ... Yen TH, Chang CT, Lin JL, Jiang JR, Lee KF (May 2003). "Scrub typhus: a frequently overlooked cause of acute renal failure". ... Flavivirus: Akhurma virus,Dengue, Hepatit C, Kyasanur Forest disease virus, Omsk hemorrhagic fever virus, Sarı ... Seitz HM (1995). "[Parasitic diseases of the liver]". Verh Dtsch Ges Pathol (German). Cilt 79, s. 241-8. PMID 8600687.. KB1 ...
The insufficiency of L-xylulose reductase activity causes an inborn error of metabolism disease characterized by excessive ... The protein is highly expressed in the kidney and localizes to the cytoplasmic membrane. ... the uronate cycle and may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by ... "Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney". J. Biol. Chem. 277 (20 ...
Hypertensive kidney disease
"Hypertensive risk factors in kidney disease in African Americans". Kidney International. Renal Disease in Racial and Ethnic ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ... "Hypertensive Nephropathy, Symptoms, Treatment, Diet and Causes - Kidney Disease Symptoms and Treatment". www.kidney-symptom.com ...
Urinary tract infection
... of chronic kidney disease in adults. Whether routine circumcision prevents UTIs has not been well studied as of 2011. ... Some, such as the American Academy of Pediatrics recommends renal ultrasound and voiding cystourethrogram (watching a person's ... "Childhood urinary tract infections as a cause of chronic kidney disease". Pediatrics. 128 (5): 840-7. doi:10.1542/peds.2010- ... "Centers for Disease Control and Prevention (CDC). 17 April 2015. Archived from the original on 22 February 2016. Retrieved 9 ...
Ultrasound of kidneys to rule out unilateral renal agenesis.. *Bone density scan (DXA) to check for osteoporosis or osteopenia. ... "Orphanet Journal of Rare Diseases. 6 (Jun 17): 41. doi:10.1186/1750-1172-6-41. PMC 3143089. PMID 21682876.. ... Absence of one of the kidneys (unilateral renal agenesis). *Skeletal defects including split hand/foot (ectrodactyly), ... Currently, no treatments exist for the lack of sense of smell, mirror movement of the hands or the absence of one kidney. ...
"Reports of kidney stone formation associated with excess ascorbic acid intake are limited to individuals with renal disease".[3 ... Other diseases. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... "Journal of Alzheimer's Disease. 29 (4): 711-26. doi:10.3233/JAD-2012-111853. PMC 3727637. PMID 22366772.. ... The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747 ...
... or absent kidneys with resultant chronic kidney disease or kidney failure. Ear anomalies include extra openings in front of the ... Branchio-oto-renal syndrome (BOR) , is an autosomal dominant genetic disorder involving the kidneys, ears, and neck. It often ... Little, Melissa Helen (2015-08-06). Kidney Development, Disease, Repair and Regeneration. Academic Press. p. 269. ISBN ... In some individuals and families, renal features are completely absent. The disease may then be termed Branchio-oto Syndrome ( ...
Eritropoetin - Wikipédia
2002) „Unexpected renal actions of erythropoietin". Experimental Nephrology 10 (5-6), 294-8. o. DOI:10.1159/000065304. PMID ... 1957) „Role of the kidney in erythropoiesis". Nature 179 (4560), 633-4. o. DOI:10.1038/179633a0. PMID 13418752. ... 2013) „Efficacy of erythropoietin combined with enteral nutrition for the treatment of anemia in Crohn's disease: a prospective ... 1996) „Erythropoietin production by interstitial cells of hypoxic monkey kidneys". British Journal of Haematology 95 (1), 27-32 ...
... which can result in kidney stones. The bacterium can be found throughout the stones, and these bacteria lurking in the kidney ... DiseaseEdit. This rod-shaped bacterium has the ability to produce high levels of urease, which hydrolyzes urea to ammonia (NH3 ... Once the stones develop, over time they may grow large enough to cause obstruction and renal failure. Proteus species can also ...
The American Kidney Fund: American Kidney Fund Warns About Impact of High-Protein Diets on Kidney Health: 25 April 2002 ... Joint WHO/FAO expert consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases (PDF). who.int. Geneva: World ... Suyoto PST (2018). "Effect of low-carbohydrate diet on markers of renal function in patients with type 2 diabetes: A meta- ... "Nutrition, Metabolism, and Cardiovascular Diseases. 24 (4): 337-43. doi:10.1016/j.numecd.2013.12.008. PMC 4351995. PMID ...
All 16 survivors have chronic kidney disease, with half developing end stage renal failure (median age 0.3 years, range 2 days ... Bilateral renal agenesis. Main article: Renal agenesis. Bilateral renal agenesis has been estimated to occur at a ... It can be caused by renal diseases such as bilateral renal agenesis (BRA), atresia of the ureter or urethra causing obstruction ... polycystic or multicystic kidney diseases, renal hypoplasia, amniotic rupture, toxemia, or uteroplacental insufficiency from ...
renal water homeostasis. • regulation of urine volume. • negative regulation of apoptotic process. • renal system development. ... AR belongs to the aldehyde-keto reductase superfamily, with a widely expression in human organs including the kidney, lens, ... The involvement in oxidative stress diseases, cell signal transduction and cell proliferation process endows AKR1B1 the ... Robinson B, Hunsaker LA, Stangebye LA, Vander Jagt DL (December 1993). "Aldose and aldehyde reductases from human kidney cortex ...
renal lesion - Kidney Disease & Disorders - MedHelp
I just found out that I have 5.5 cm x 6.5 cm renal lesion on right side after having MRI for my lower back pain. I am due to ... renal lesion. I just found out that I have 5.5 cm x 6.5 cm renal lesion on right side after having MRI for my lower back pain. ... Bosniak Classification of Renal Cystic Disease Category I. --- Category I lesions are simple benign cysts showing homogeneity, ... Bosniak Classification of Renal Cystic Disease Category I. --- Category I lesions are simple benign cysts showing homogeneity, ...
Renal fullness - Kidney Disease & Disorders - MedHelp
I just had an abdominal ultrasound which revealed right renal pelvic fullness and fullness of both collecting systems. No other ... Renal fullness. I just had an abdominal ultrasound which revealed right renal pelvic fullness and fullness of both collecting ... What could cause renal fullness if there are no stones, masses or cysts? I have had UTIs in the past, could it be scarring? i ... What could cause renal fullness if there are no stones, masses or cysts? I have had UTIs in the past, could it be scarring? i ...
04Chronic Renal Failure | Chronic Kidney Disease | Kidney
Chronic Renal FailureA. Definitions 1. Azotemia - elevated blood urea nitrogen (BUN ,28mg/dL) and creatinine (Cr,1.5mg/dL) 2. ... Renal Vascular Disease . a. f.about 5% of cases Rapidly progressive glomerulonephritis (vasculitis) .1. Renal (glomerular) ... Increased PTH levels leads to renal bone disease d.5-3mg/dL c. a. .Anemia Due to reduced erythropoietin production by kidney b ... Goal B/P 130/80 mmHg for all renal patients. African American study of kidney disease (AASK). ACE ,,BB or CCB Heart Outcome ...
Pediatric End Stage Kidney (Renal) Disease (ESRD)
... If your child has renal ... the team who works on helping to diagnose kidney disease and renal failure are experienced in treating childhood kidney disease ... CMC_Design/childrens/conditions/Acute Kidney Injury,/CMC_Design/childrens/conditions/Chronic Kidney Disease CKD,/CMC_Design/ ... youre backed by a team of pediatric kidney disease specialists who are trained to diagnose and treat childhood kidney disease ...
Kidney Diseases | Renal Disease | MedlinePlus
A renal disease can be attributed to a variety of causes which, include genetics, injuries and medicine. Find a full list of ... Pain Medicines (Analgesics) (National Kidney Foundation) * Renal Disease and Adult Vaccination (Centers for Disease Control and ... FastStats: Kidney Disease (National Center for Health Statistics) * Kidney Disease Statistics for the United States (National ... Ectopic Kidney (National Institute of Diabetes and Digestive and Kidney Diseases) * Hydronephrosis (National Kidney Foundation) ...
Petition · Ontario Renal Network: Kidney Disease Care Closer to Home · Change.org
In Ontario, Cancer Care Ontario (CCO) and the Ontario Renal Network (ORN) coordinate the care of patients with kidney disease. ... We want the Ontario Renal Network to support the development of a Regional Chronic Kidney Disease Centre at Trenton Memorial ... David Weinstein needs your help with "Ontario Renal Network: Kidney Disease Care Closer to Home". Join David and 1,951 ... David Weinstein needs your help with "Ontario Renal Network: Kidney Disease Care Closer to Home". Join David and 1,951 ...
Multiple loci associated with indices of renal function and chronic kidney disease | Nature Genetics
They show that variants at UMOD, a gene previously implicated in rare monogenic forms of kidney disease, are associa… ... and colleagues report results of a genome-wide association study to identify common variants associated with indices of renal ... US Renal Data System, USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United ... Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease ...
Hospice Eligibility Guidelines: Renal & Kidney Disease
Learn about clinical appropriateness hospice eligibility for your patients with end-stage kidney failure, and download a PDF of ... Is your renal disease patient ready for hospice? ... The hospice plan of care for renal disease The hospice plan of ... Hospice Eligibility Guidelines for End-Stage Renal Disease (ESRD) Download a PDF of these guidelines.. Renal Disease Guidelines ... 25%-30% of patients on dialysis who are declining with other comorbid disease, such as cancers, end-stage heart disease, end- ...
Chronic Kidney Disease Workup: Approach Considerations, Renal Function Formulas, Renal Ultrasonography
... or chronic renal failure (CRF), as it was historically termed-is a term that encompasses all degrees of decreased renal ... function, from damaged-at risk through mild, moderate, and severe chronic kidney failure. CKD is a worldwide public health ... Blood Pressure Components and End-stage Renal Disease in Persons With Chronic Kidney Disease: The Kidney Early Evaluation ... Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA. ...
Kidney Disease and Renal Failure in Dogs | Blue Cross
... treatment of the condition and how to care for your pet if it has renal failure. ... Find out more about the signs and symptoms of kidney disease in dogs, ... What causes renal disease in dogs?. There are many different causes of kidney disease in dogs. Certain breeds are more ... Any condition which stops the kidneys working properly is referred to kidney or renal disease, and can vary greatly in severity ...
M2 Renal- Diseases of the Kidney Upper Urinary Tract
... The M2 Renal Sequence provides an overview of diseases of the kidney and ... nephrology, urinary tract diseases, kidney, kidney disease, renal failure, urinary tract Disciplines:. * Science and Technology ... You just viewed M2 Renal- Diseases of the Kidney.... Please take a moment to rate this material. ... Disciplines with similar materials as M2 Renal- Diseases of the Kidney Upper Urinary Tract ...
NCT01473407 | Chronic Kidney Disease, Chronic Renal Failure Clinical Trial | Pfizer
End-stage renal disease - Kidney Health - MedBroadcast.com
End-stage renal disease. End-stage renal disease (ESRD) occurs when your kidneys are functioning at less than 15% of normal. At ... this stage, your kidneys are no longer able to work well enough to keep you alive, and you will need dialysis or a kidney ... End-stage renal disease (ESRD) occurs when your kidneys are functioning at less than 15% of normal. At this stage, your kidneys ... The most common cause of end-stage renal disease is chronic kidney disease due to high blood pressure or diabetes. ...
Blood Pressure Components and End-Stage Renal Disease in Persons with Chronic Kidney Disease - RWJF
A higher systolic blood pressure goal than previously thought desirable may be enough to prevent kidney disease from ... People with chronic kidney disease who have high blood pressure are at risk of progressing to end-stage renal disease. Meeting ... Subscription required: Blood Pressure Components and End-Stage Renal Disease in Persons With Chronic Kidney Disease (Web) ... Blood Pressure Components and End-Stage Renal Disease in Persons with Chronic Kidney Disease. * *January 9, 2012 ...
Renal Nerve Ablation in Chronic Kidney Disease Patients - Full Text View - ClinicalTrials.gov
Renal denervation preserves renal function in patients with chronic kidney disease and resistant hypertension. J Hypertens. ... Renal Nerve Ablation in Chronic Kidney Disease Patients. The safety and scientific validity of this study is the responsibility ... A)Preservation of renal function and perfusion B)Reduction of local RAS activity in the kidney C)Exaggerated sodium excretion ... change in renal perfusion measured by MRI spin labelling technique from baseline to 1 day and 1 months post-renal nerve ...
Kidney Disease Advocacy | Renal Support Network
Learn how RSNs WeKAN program and other activities support kidney disease advocacy and learn how you can become a kidney ... How the New Health Care Law Could Affect People with Kidney Disease. ... Prevent or Slow the Progression of Kidney Disease from High Blood Pressure ... Prevent or Slow the Progression of Kidney Disease from High Blood Pressure ...
Kidney Disease Resources | Renal Support Network
There is help out there for you whether you are pre-dialysis, are on dialysis or have received a kidney transplant. ... no matter what stage of the disease you are experiencing. ... Resources for people who have kidney disease and their families ... Kidney Disease *Learn About Kidney Disease. *Are You at Risk of Developing Kidney Disease? *Are You at Risk of Developing ... Kidney Disease *Learn About Kidney Disease. *Are You at Risk of Developing Kidney Disease? *Are You at Risk of Developing ...
Chronic Kidney Disease Associated with Increased Renal Cancer Risk | Article | NursingCenter
Prior studies have shown that end-stage renal disease is associated with an increased risk of a variety of cancers. Now, ... Currently, approximately 13.5 million Americans have stage 3 or worse chronic kidney disease (eGFR of 59 ml/min/1.73 m2 or ... Cancer Institute and colleagues found that chronic kidney disease is significantly associated with an increased risk of renal ... Lowrance said that given the significant relationship between the chronic disease and renal cancer risk, that eGFR may be a ...
Anemia in Chronic Kidney Disease (Renal Anemia) - Pipeline Review, H2 2016
Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Anemia in Chronic Kidney Disease ... Renal is a term that means of the kidneys, so anemia is often associated with kidney disease. This type of anemia is caused by ... Chronic Kidney Disease (Renal Anemia) - Pipeline Review, H2 2016. LONDON, March 9, 2017 /PRNewswire/ -- SummaryGlobal Markets ... Anemia in Chronic Kidney Disease (Renal Anemia) - Pipeline Review, H2 2016. Friday, March 10, 2017 General News ...
Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation | PNAS
Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. M L ... Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation ... Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation ... Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation ...
Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation
... and in children with chronic kidney disease (CKD) and its associations to cardiovascular risk factors. In this cross-sectional ... The levels were not associated with traditional cardiovascular risk factors but strongly associated with renal function. ... and kidney function. Forty healthy children served as a control group. Plasma levels of GDF-15 (median and range) for a Tx ( ... The aim of our study was to evaluate plasma and urinary levels of GDF-15 after pediatric renal transplantation (Rtx) ...
Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease | CMAJ
Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease. Carl van Walraven, ... Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease ... Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease ... Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease ...
Mom with Renal and Crohn's disease - Kidney Diseases & Disorders - HealingWell.com Forum
Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease
1992). Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease. Kidney International ... 2002). Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a ... End-stage renal disease Introduction The autosomal dominant polycystic kidney disease (ADPKD) belongs to a group of inherited ... 1998). The association of nephrolithiasis and autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases ...
Kidney (Renal) Artery Disease
Renal artery disease is a form of peripheral artery disease that reduces blood flow through the renal arteries, which supply ... Kidney (Renal) Artery Disease. *In Peripheral Vascular Disease. What is kidney (renal) artery disease?. Renal artery disease is ... Illustration of renal arteries and kidneys showing early stages of renal artery disease. At this stage, kidney size and ... and sometimes kidney problems are the first sign of disease. Kidney signs that may point to renal artery disease include:. * ...
Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal Insufficiency - Tabular View - ClinicalTrials.gov
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary renal disease, responsible for the 8% to 10 ... EFFECTS OF SIROLIMUS ON DISEASE PROGRESSION IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND SEVERE RENAL ... Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal Insufficiency (SIRENA-II). This study has been ... Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal Insufficiency. Official Title ICMJE ...
Amygdalin inhibits renal fibrosis in chronic kidney disease
Liu N, Tolbert E, Pang M, Ponnusamy M, Yan H and Zhuang S: Suramin inhibits renal fibrosis in chronic kidney disease. J Am Soc ... Guo, J., Wu, W., Sheng, M., Yang, S., Tan, J.Amygdalin inhibits renal fibrosis in chronic kidney disease. Molecular Medicine ... Guo, J., Wu, W., Sheng, M., Yang, S., Tan, J.Amygdalin inhibits renal fibrosis in chronic kidney disease. Molecular Medicine ... Guo, J., Wu, W., Sheng, M., Yang, S., & Tan, J. (2013). Amygdalin inhibits renal fibrosis in chronic kidney disease. Molecular ...
Betulinic acid attenuates renal fibrosis in rat chronic kidney disease model. | Sigma-Aldrich
Most chronic kidney diseases (CKDs), regardless of the nature of the initial injury, progress to end-stage renal disease (ESRD ... Betulinic acid attenuates renal fibrosis in rat chronic kidney disease model.. [Anshuk Sharma, Richa Thakur, Madhu C Lingaraju ... The present study was undertaken to investigate the effect of BA on renal fibrosis in the rat model of adenine-induced CKD. CKD ... It has been shown to a possess variety of beneficial effects in many disease conditions. However, its efficacy against CKD is ...
3-D Kidney Atlas To Help Physicians Treat Renal Diseases
In a bid to diagnose and treat renal diseases early and more successfully, researchers from nine European countries have spent ... Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Kidney Biopsy Prevention of Kidney Disease ... While the primary aim of the Kidney Atlas is to map genes that play a key role in renal diseases, it also contains other data, ... Prevention of Kidney Disease. Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and ...
Kidney (renal) artery disease Diagnosis Overview
Kidney Artery Disease Diagnosis Overview. *In Tests & Diagnosis. Kidney (renal) artery disease is a form of peripheral artery ... If your kidney artery disease is severe (a renal artery is more than 50% blocked) or causing damage to your kidney or other ... If you have any of the following signs of kidney artery disease, you may require further tests to look at the renal arteries:2 ... It is also called renal artery stenosis (RAS).. You may be evaluated for kidney artery disease if your doctor notices certain ...
HypertensionAutosomalPolycysticNephrologyInfluencing renal functionProgressionAutosomalProgressive renalHypertensionOutcomesDisordersPrevalenceSigns of renal failureSevereStage Renal DiseaseHematuriaBiopsyGeneticDevelopment of renalHereditaryExcretionEGFRCenters for DiseasFindingsCystic kidney disease anTissueRisk of renalLoss of renalHemodialysisAcute renalPediatricArtery diseaseExtrarenal manifestationsStonesFamilialStenosisPatients with chronicMedullary
- Autosomal recessive polycystic kidney disease (ARPKD) is the recessive form of polycystic kidney disease . (snpedia.com)
- An additional resource beyond ClinVar for PKHD1 mutations and their association with autosomal recessive polycystic kidney disease is the RWTH-Aachen ARKPD/PKHD1 database. (snpedia.com)
- The objective of the present study was to determine the frequency of the most common clinical features in patients with autosomal dominant polycystic kidney disease in a sample of the Brazilian population. (scielo.br)
- The medical records of 92 patients with autosomal dominant polycystic kidney disease attended during the period from 1985 to 2003 were reviewed. (scielo.br)
- The autosomal dominant polycystic kidney disease (ADPKD) belongs to a group of inherited polycystic kidney diseases (1) and is one of the most common hereditary disorders. (scielo.br)
- The general aim of this study in adult patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and severe renal insufficiency is to assess the safety and the efficacy of sirolimus (SRL) in slowing renal function decline as compared to conventional therapy. (clinicaltrials.gov)
- Unlike patients with polycystic kidney disease, patients with nephronophthisis rarely develop flank pain, hematuria, hypertension, urinary tract infections (UTIs), or renal calculi. (renalandurologynews.com)
- However, a patient's level of risk may be related to whether the patient also has polycystic kidney disease (PKD). (renalandurologynews.com)
- GCKD can also occur in conjunction with tuberous sclerosis complex (TSC), juvenile nephronopthisis, Meckel-Gruber syndrome, Jeune's syndrome, Zellweger's syndrome, trisomy 13, orofaciodigital syndrome type 1, and early-onset autosomal dominant polycystic kidney disease (ADPKD). (oncologynurseadvisor.com)
- Does this patient have autosomal dominant polycystic disease? (psychiatryadvisor.com)
- Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease characterized by cyst formation in the kidneys and a spectrum of extrarenal manifestations with variable penetrance. (psychiatryadvisor.com)
- PKD1, one of the genes responsible for ADPKD, was identified in 1994 on the short arm of chromosome 16 next to the TSC2 gene in a Portuguese family with both autosomal dominant polycystic kidney disease (ADPKD) and tuberous sclerosis complex (TSC). (psychiatryadvisor.com)
- A third gene locus causing autosomal dominant polycystic kidney (and liver) disease was recently identified, and involves the GANAB gene, encoding the ER-resident glucosidase II, subunit α. (psychiatryadvisor.com)
- autosomal recessive diseases, including autosomal recessive polycystic kidney disease (ARPKD) and familial juvenile nephronopthisis (FJN), are less common and present in a single generation of affected individuals. (psychiatryadvisor.com)
- Jade-1 is also strongly regulated by the products of the autosomal dominant polycystic kidney disease (ADPKD) genes, the polycystins. (bu.edu)
- Achievements by Mayo researchers in polycystic kidney disease have had direct impact on patient care. (mayo.edu)
- These include the identification of the major gene for the most common genetic disease of the kidney, autosomal dominant polycystic kidney disease (ADPKD), and the gene responsible for the devastating infantile form of the disease, autosomal recessive polycystic kidney disease (ARPKD). (mayo.edu)
- Localisation of a mutation producing autosomal dominant polycystic kidney disease without renal failure. (bmj.com)
- A four generation Finnish family was identified with atypical features of adult polycystic kidney disease. (bmj.com)
- Previous studies have shown close linkage between the adult polycystic kidney disease locus and the alpha chain of human haemoglobin on chromosome 16, but these studies were carried out on families manifesting 'typical' clinical features of the disease. (bmj.com)
- Tolvaptan, a selective vasopressin V 2 receptor antagonist, slows the increase in total kidney volume and the decline in kidney function in patients with the results of the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Outcome (TEMPO) 3:4 trial. (aspetjournals.org)
- Autosomal-dominant polycystic kidney disease is a systemic disorder and the most common hereditary renal disease, which is characterized by cyst growth, progressive renal enlargement, and development of renal failure. (asnjournals.org)
- This article reviews the indications, comparative use, and limitation of various imaging modalities (ultrasonography, magnetic resonance imaging, computerized tomography scan, Positron emission tomography scan, and renal scintigraphy) for the diagnosis and management of complications in autosomal dominant polycystic kidney disease. (asnjournals.org)
- Finally, this work provides evidence for the value of total kidney volume to predict disease progression in autosomal dominant polycystic kidney disease. (asnjournals.org)
- There are two identified genes, polycystic kidney disease 1 ( PKD1 ) and PKD2 , that code for polycystin 1 and 2, respectively. (asnjournals.org)
- The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. (figshare.com)
- Cairn Terriers can be affected by polycystic kidney disease. (wikipedia.org)
- Our nephrology department staff and the team who works on helping to diagnose kidney disease and renal failure are experienced in treating childhood kidney disease. (childrens.com)
- The nephrology society also disagreed with the ACP's recommendation against testing for proteinuria, whether or not diabetes is present, in adults taking an ACE inhibitor or an ARB, emphasizing the importance of renal health assessment in adults on antihypertensive medication. (medscape.com)
- Prevalence of chronic kidney disease in the Japanese general population," Clinical and Experimental Nephrology , vol. 13, no. 6, pp. 621-630, 2009. (hindawi.com)
- Prevalence of kidney damage in Australian adults: the AusDiab kidney study," Journal of the American Society of Nephrology , vol. 14, no. 2, pp. (hindawi.com)
- Brachial-ankle pulse wave velocity and rate of renal function decline and mortality in chronic kidney disease," Clinical Journal of the American Society of Nephrology , vol. 6, no. 4, pp. 724-732, 2011. (hindawi.com)
- Lower progression rate of end-stage renal disease in patients with peripheral arterial disease using statins or angiotensin-converting enzyme inhibitors," Journal of the American Society of Nephrology , vol. 18, no. 6, pp. 1872-1879, 2007. (hindawi.com)
- Rapid decline of kidney function increases cardiovascular risk in the elderly," Journal of the American Society of Nephrology , vol. 20, no. 12, pp. 2625-2630, 2009. (hindawi.com)
- Ankle brachial index as a predictor for mortality in patients with chronic kidney disease and undergoing haemodialysis," Nephrology , vol. 15, no. 3, pp. 294-299, 2010. (hindawi.com)
- Methods and Results- This retrospective cohort study involved 2964 chronic kidney disease subjects referred between January 2001 and December 2008 to the nephrology clinic at Sunnybrook Health Sciences Center, Toronto, Ontario. (ahajournals.org)
- AstraZeneca (NYSE: AZN) will present new research spanning the Company's Cardiovascular, Renal and Metabolism (CVRM) therapy area at the American Society of Nephrology (ASN) Kidney Week Annual Meeting in San Diego, US, October 23-28, 2018. (astrazeneca-us.com)
- Contemporaneously, the Renal Association and the British Association for Paediatric Nephrology have developed a strategy for patients with rare kidney diseases. (renal.org)
- The pre-clinical nephrology field would benefit from reproducible progressive renal disease models in mice in order to avail of more widely available transgenics and experimental tools to dissect mechanisms of disease. (medworm.com)
- ASN Renal Week Clinical Nephrology Conference Extract, November, 2008. (hdcn.com)
- Nephrology societies around the world have released a joint statement calling for actions from governments and agencies overseeing care of patients with kidney disease. (renal.org)
Influencing renal function1
- Slow progression of disease due to chronic daily ingestion of analgesics b. (scribd.com)
- Although there is no cure for chronic renal disease, early intervention can sometimes limit the damage done to the kidneys and slow the progression of the disease. (bluecross.org.uk)
- However, whether amygdalin inhibits the progression of renal fibrosis or not remains unknown. (spandidos-publications.com)
- Although these strategies promote renoprotective effects, they fail to arrest the progression of renal fibrosis and scarring. (spandidos-publications.com)
- The results suggested that amygdalin is a potent drug that can be used to reduce renal fibrosis during CKD progression and that its therapeutic mechanism, at least in part, blocks interstitial fibroblast cell activation. (spandidos-publications.com)
- This is an international, multicentre, event-driven, randomized, double-blind, parallel group, placebo-controlled study, evaluating the effect of dapagliflozin versus placebo, given once daily in addition to standard of care, to prevent the progression of chronic kidney disease (CKD) or cardiovascular (CV)/renal death. (centerwatch.com)
- Rapid renal progression was defined as eGFR slope less than -3 ml/min/1.73 m 2 /year. (medsci.org)
- A pre-specified exploratory analysis of renal data from the Phase III DECLARE-TIMI 58 trial, the broadest cardiovascular outcomes trial of a sodium-glucose co-transporter 2 (SGLT2) inhibitor, showed that FARXIGA ® (dapagliflozin) reduced the progression of kidney disease or renal death in patients with type 2 diabetes (T2D). (astrazeneca-us.com)
- Mrs. Ford has written books on topics related to kidney disease from nutrition to the emotional changes that happen during kidney disease progression. (bio-medicine.org)
- and 3 ) to provide either a more sensitive index or an early index of disease progression. (physiology.org)
- Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to renal failure by the age of 9 months and death by 16 months. (wikipedia.org)
- Nephronophthisis comprises a group of genetic tubulointerstitial disorders with autosomal recessive pattern of inheritance (Figure 1) that progress to end-stage renal failure and that are clinically sub-classified by the variability in age of occurrence and the presence of syndromatic extrarenal manifestations. (renalandurologynews.com)
- Autosomal-recessive disease that is limited to the kidneys is then subclassified as infantile, juvenile or adolescent nephronophthisis, depending on the age of symptoms. (renalandurologynews.com)
- The pedigree of a family affected with autosomal dominant glomerulocystic kidney disease. (oncologynurseadvisor.com)
- It is inherited through an autosomal dominant mechanism and can progress to kidney disease later in life. (wikipedia.org)
- Dr. Grauer left his colleagues in the audience with an important question: Are proteinuria and hypertension simply markers of more severe chronic kidney disease that is more likely to be rapidly progressive, or do one or both mediate progressive renal injury? (prweb.com)
- If they do mediate progressive renal injury, then treatments designed to attenuate them, to lower or normalize blood pressure or to reduce proteinuria, are likely to be renoprotective and improve survival," adds Dr. Grauer. (prweb.com)
- Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in rats to model progressive renal disease. (medworm.com)
- The participants were part of the Kidney Early Evaluation Program, a health screening program for people with kidney disease, a history of diabetes or hypertension, or a family history of kidney disease. (rwjf.org)
- In patients with treatment resistent hypertension renal nerve ablation emerged as an effective interventional approach of treating hypertensive disease with a progressively increasing fall in blood pressure. (clinicaltrials.gov)
- Ablation of greater than 70% of renal mass in the rat results in hypertension, proteinuria, and glomerular sclerosis of the remnant kidney. (pnas.org)
- In this cross-sectional study, GDF-15 was measured in plasma and urine from 53 children with a renal transplant and 83 children with CKD and related to cardiovascular risk factors (hypertension, obesity, and cholesterol) and kidney function. (hindawi.com)
- Renal disease not only affects the elderly because of hypertension and diabetes, but also targets children, who are often born with congenital renal anomalies. (medindia.net)
- Anyone have similar experiences with renal artery stenosis or renovascular hypertension, can be due to atherosclerosis or fibromuscular dysplasia(FMD). (healingwell.com)
- When atherosclerosis clogs up the arteries leading to the kidneys (the renal arteries), it causes kidney artery disease, which is also known as renal artery stenosis (RAS), renovascular disease, renovascular hypertension and ischemic nephropathy . (secondscount.org)
- reduced kidney function in adolescence or childhood, lack of significant hypertension or detectable proteinuria and bland urine sediment, normal to reduced kidney size on ultrasound with increased echogenicity and loss of the corticomedullary junction. (renalandurologynews.com)
- Dr. Atkins wants veterinarians to feel comfortable using ACEIs in patients with phase II cardiac disease and beyond, and recognize that ACEIs are probably indicated from the time proteinuria is identified in patients with renal disease, and finally, that ACEIs are indicated from the time a patient is identified to have systemic hypertension. (prweb.com)
- The elderly are disproportionately affected, as the disease frequently develops as a consequence of hypertension and diabetes. (bio-medicine.org)
- Neonates can present with hypertension, abdominal masses, early onset diabetes, and variable degrees of renal failure, while adults typically present with flank pain, hematuria, and hypertension. (oncologynurseadvisor.com)
- OBJECTIVE -Diabetes, hypertension, infections, and nephrotoxicity of certain immunosuppressive drugs (i.e., calcineurin inhibitors) can reduce functional survival of the kidney graft. (diabetesjournals.org)
- Impact of contrast-induced acute kidney injury after percutaneous coronary intervention on short- and long-term outcomes: pooled analysis from the HORIZONS-AMI and ACUITY trials. (springer.com)
- We examined the association between albumin and indexed LAD (indexed to height) and assessed whether the combination of indexed LAD and albumin was independently associated with renal outcomes in patients with CKD stages 3-5. (medsci.org)
- Assessments of serum albumin and indexed LAD by echocardiography are useful for predicting the risk for adverse renal outcomes. (medsci.org)
- These data were presented alongside other clinically important renal outcomes data from the DECLARE-TIMI 58 trial, including positive results from another sub-analysis that evaluated UACR, a key marker of kidney health. (astrazeneca-us.com)
- pipeline guide Anemia in Chronic Kidney Disease Pipeline Review, H2 2016, provides an overview of the Anemia in Chronic Kidney Disease (Hematological Disorders) pipeline landscape.Download the full report: https://www.reportbuyer.com/product/4603784/ Renal anemia is a disease in which the patient has an unusually low count of red blood cells. (medindia.net)
- Report Highlights Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Anemia in Chronic Kidney Disease Pipeline Review, H2 2016, provides comprehensive information on the therapeutics under development for Anemia in Chronic Kidney Disease (Hematological Disorders), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (medindia.net)
- The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.The Anemia in Chronic Kidney Disease (Hematological Disorders) pipeline guide also reviews of key players involved in therapeutic development for Anemia in Chronic Kidney Disease (Renal Anemia) and features dormant and discontinued projects. (medindia.net)
- Scope - The pipeline guide provides a snapshot of the global therapeutic landscape of Anemia in Chronic Kidney Disease (Hematological Disorders). (medindia.net)
- The pipeline guide reviews pipeline therapeutics for Anemia in Chronic Kidney Disease (Hematological Disorders) by companies and universities/research institutes based on information derived from company and industry-specific sources. (medindia.net)
- The pipeline guide reviews key companies involved in Anemia in Chronic Kidney Disease (Hematological Disorders) therapeutics and enlists all their major and minor projects. (medindia.net)
- The pipeline guide evaluates Anemia in Chronic Kidney Disease (Hematological Disorders) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (medindia.net)
- The pipeline guide reviews latest news related to pipeline therapeutics for Anemia in Chronic Kidney Disease (Hematological Disorders) Reasons to buy - Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies. (medindia.net)
- Find and recognize significant and varied types of therapeutics under development for Anemia in Chronic Kidney Disease (Hematological Disorders). (medindia.net)
- Other less common causes include renal artery aneurysm (weakening of the artery wall that causes it to bulge out and eventually rupture) and some rare disorders of the artery lining. (simstat.com)
- Project coordinator, Professor Thomas Willnow (MDC), has said that the Kidney Atlas will also be of great significance for the research of metabolic disorders, which lead to kidney damage such as diabetes. (medindia.net)
- The similar appearance of the renal histology in cases of FJN and MCKD led to the historical association of these two disorders. (psychiatryadvisor.com)
- Background Inherited cystic kidney disorders are a common cause of end-stage renal disease. (bmj.com)
- Manipal Hospitals' team of highly skilled nephrologists & urologists rely on the state of the art diagnostic labs to identify and diagnose kidney disorders, producing effective results in time critical situations. (manipalhospitals.com)
- Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity 1 . (nature.com)
- In patients with diabetic kidney disease (DKD), the prevalence of end-stage renal disease (ERSD) in the early-onset group was twofold higher than it was in the late-onset group. (cdc.gov)
- CONCLUSIONS: The prevalence of adverse renal effects after treatment with cisplatin, carboplatin, ifosfamide, radiation therapy involving the kidney region, nephrectomy, or any combination of these, ranged from 0% to 84% depending on the study population, received treatment combination, reported outcome measure, follow-up duration and methodological quality. (medworm.com)
- With currently available evidence, it was not possible to draw solid conclusions regarding the prevalence of, and treatment-related risk factors for, specific adverse renal effects. (medworm.com)
- It is estimated that the prevalence of cystic kidney disease is 4.81% in the Arabian Gulf countries. (bmj.com)
Signs of renal failure3
- Whether acute or chronic, be on the look out for these signs of renal failure: change in water and urinated intake, depression and listlessness, anorexia, halitosis and mouth ulcers, vomiting and stumbling/disorientation. (holistic-pet-care.com)
- Be aware of the signs of renal failure and get blood work done by your veterinarian if you suspect your dog may be experiences renal failure. (holistic-pet-care.com)
- As soon as your pet appears to be showing any of the above signs of renal failure, take him to your vet immediately. (homehealth-uk.com)
- Exposure to low humidity makes mice infected with influenza more susceptible to severe disease by impairing airway tissue repair and innate antiviral defense, suggesting that controlling humidity may help curb influenza during winter. (pnas.org)
- Illustration of renal arteries and kidney showing severe plaque buildup in the renal arteries and aorta , which has cut off blood flow to the kidneys and caused them to shrink. (simstat.com)
- Severe high blood pressure, especially in younger women, is often the first sign of kidney artery disease. (simstat.com)
- Imaging tests allow doctors to determine if one or both of your main kidney arteries is narrowed or blocked and how severe the blockage is. (simstat.com)
- In severe cases, renal failure in utero gives rise to oligohygramnios and a Potter sequence, and among many secondary malformations, pulmonary hypoplasia and postpartum respiratory failure represent the most important cause of morbidity and mortality. (renalandurologynews.com)
- It is noted, however, that beyond those three forms of pediatric kidney disease, mutant alleles of all NPHP1-3 genes are being found in more severe, syndromic cases of nephronophthisis, with catastrophic multiorgan malformations. (renalandurologynews.com)
- 60 mL/min/1.73m 2 ) are at increased risk of cardiovascular (CV) disease when compared with patients with less severe chronic kidney disease. (ahajournals.org)
- None of the patients were pregnant or supplementing vitamin D and/or curcumin, nor did they have liver dysfunction disorder or severe kidney disease. (naturalnews.com)
- Results In this cohort, disease phenotypes were severe with 36 cases of stillbirth or perinatal death. (bmj.com)
Stage Renal Disease12
- US Renal Data System, USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States (National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, 2008). (nature.com)
- The sequence consists of lectures, small group seminars, Clinicopathological Correlation Laboratories, and multidisciplinary conferences on end stage renal disease and organ procurement. (merlot.org)
- The most common cause of end-stage renal disease is chronic kidney disease due to high blood pressure or diabetes. (medbroadcast.com)
- The role of high blood pressure as a cause of end-stage renal disease is subject to debate. (medbroadcast.com)
- People with chronic kidney disease who have high blood pressure are at risk of progressing to end-stage renal disease. (rwjf.org)
- Prior studies have shown that end-stage renal disease is associated with an increased risk of a variety of cancers. (nursingcenter.com)
- Tubulointerstitial fibrosis is the final common pathway in late-stage renal disease. (spandidos-publications.com)
- Serum Potassium, End-Stage Renal Disease and Mortality in Chronic Kidney Disease. (medworm.com)
- Risks for end-stage renal disease, cardiovascular events, and death in Hispanic versus non-Hispanic white adults with chronic kidney disease. (nih.gov)
- Risk of bladder and kidney cancers in end-stage renal disease patients: a nationwide, population-based study in Taiwan. (aacrjournals.org)
- OBJECTIVE: Patients with end-stage renal disease treated with chronic hemodialysis (HD) are reported to have low levels of marine n-3 polyunsaturated fatty acids (PUFA) in plasma and cell membranes compared with healthy subjects. (biomedsearch.com)
- BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. (iupui.edu)
- Given the inconsistent nature of GCKD, it is clinically difficult to diagnose and can only be established by renal biopsy. (oncologynurseadvisor.com)
- A biopsy is necessary to distinguish MCKD from glomerular cystic disease where cystic dilation of Bowman's capsule and the initial proximal convoluted tubule. (psychiatryadvisor.com)
- Immunohistochemical studies of biopsy samples from a wide range of renal diseases revealed a substantial and striking upregulation of AQP-1 in the glomeruli of most diseased kidneys. (asnjournals.org)
- Archival human renal biopsy samples of differing pathologies and normal human kidney tissue (nephrectomy specimens) were processed for immunohistochemistry by means of standard techniques. (asnjournals.org)
- A biopsy of one, or both, of the kidney's may be felt necessary as a biopsy can be very helpful towards diagnosing the extent of disease and what treatment to proceed with. (homehealth-uk.com)
- The second most common cause of renal artery disease is fibromuscular dysplasia(FMD), a genetic disease that makes cells in the artery walls grow abnormally, reducing blood flow. (simstat.com)
- Genetic analysis of this entity gave rise to the identification of the inversin gene (INVS) as a disease gene. (renalandurologynews.com)
- partially they derive from the complex renal organogenesis, and partially they have a genetic background. (springer.com)
Development of renal1
- Glomerulocystic kidney disease (GCKD) is a rare form of hereditary renal cystic disease characterized by cystic dilation of Bowman's capsule and the initial proximal convoluted tubule. (oncologynurseadvisor.com)
- Avni EF, Garel L, Cassart M et al (2006) Perinatal assessment of hereditary cystic renal diseases: the role of sonography. (springer.com)
- The adjusted hazard ratio for renal cancer was 1.35 for individuals with an eGFR of 45-59 ml/min/1.73 m 2 compared with individuals with an eGFR of 60-89 ml/min/1.73 m 2 , 1.65 for individuals with an eGFR of 30-44 ml/min/1.73 m 2 , and 2.09 for individuals with an eGFR below 30 ml/min/1.73 m 2 . (nursingcenter.com)
- Currently, approximately 13.5 million Americans have stage 3 or worse chronic kidney disease (eGFR of 59 ml/min/1.73 m 2 or lower). (nursingcenter.com)
- Lowrance said that given the significant relationship between the chronic disease and renal cancer risk, that eGFR may be a useful way to identify individuals for renal cancer screening. (nursingcenter.com)
- These findings from a large, community-based study suggest that a blood pressure goal of 140/90, rather than the more aggressive and difficult-to-attain 130/80, may be sufficient for people with chronic kidney disease. (rwjf.org)
- These data are further fortified by histological findings where kidney damage and fibrosis are clearly evident as dilatation of tubules, glomerular degeneration and vacuolation along with deposition of collagen fibers. (sigmaaldrich.com)
- In a bid to diagnose and treat renal diseases early and more successfully, researchers from nine European countries have spent four-and-a half years to create a three-dimensional virtual "Kidney Atlas", which incorporates the latest research findings on the development and diseases of the kidney. (medindia.net)
- It incorporates the latest research findings on the development and diseases of the kidney. (bio-medicine.org)
Cystic kidney disease an1
- The pathogenesis of kidney fibrosis is characterized by the overproduction and deposition of extracellular matrix (ECM), which ultimately leads to fibrotic lesions and tissue scarring ( 2 , 3 ). (spandidos-publications.com)
- Further, in comparison to control rats, kidney samples from CKD rats revealed increased profibrotic protein levels like transforming growth factor-beta (TGF-β), connective tissue growth factor (CTGF), fibronectin, collagen type I and hydroxyproline indicating a progressive fibrotic response. (sigmaaldrich.com)
- A basic tenet in pediatric urology is that kidney infections should be prevented and otherwise promptly identified to minimize the risk of acquiring renal scars and permanent tissue damage. (clinicaltrials.gov)
- As more nephrons are lost, "the RAAS brings more vasopressor agents to bear and more tissue remodeling to bear, and at the level of the kidney that's associated with increased fibrous scar tissue production. (prweb.com)
- Precision-cut slices (200-300 µm thickness) were prepared from healthy C57BL/6 mouse kidneys using a Krumdieck tissue slicer. (biologists.org)
- Major advantage of the slice model is that it can be used not only for animal but also for (fibrotic) human kidney tissue. (biologists.org)
- Renal dysplasia is a type of familial renal disease characterized by abnormal cellular differentiation of renal tissue. (wikipedia.org)
Risk of renal1
Loss of renal1
- combinations of acute renal insults are additive and lead to CRF 3. (scribd.com)
- This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. (clinicaltrials.gov)
- This proposal hypothesizes that the quick renal MRI has high validity compared to the DMSA scan in the detection of acute renal infections and scars. (clinicaltrials.gov)
- In women with renal artery disease, blood flow to the kidneys is reduced or cut off, which may cause high blood pressure and potentially permanent damage to the kidneys. (simstat.com)
- Women with renal artery disease often have some degree of coronary artery disease, carotid artery disease, peripheral artery disease, or aortic disease, and are at increased risk for heart attack and stroke. (simstat.com)
- What causes renal artery disease? (simstat.com)
- FMD is a common cause of renal artery disease in women aged 25 to 50, although it can occur in both genders at any age. (simstat.com)
- Who is at risk for renal artery disease? (simstat.com)
- Women with coronary artery disease, carotid artery disease , or peripheral artery disease in the legs are at high risk for renal artery disease. (simstat.com)
- One in 13 women who undergo cardiac catheterization because of suspected coronary artery or aortic disease have significant renal artery disease.4,5 It is not known why renal artery disease is more common in women than men in this population. (simstat.com)
- It is often discovered in women who are undergoing evaluation for other problems such as coronary artery disease, peripheral artery disease of the legs, or high blood pressure, or on routine blood tests that suggest the kidneys are not working properly. (simstat.com)
- Because the kidneys regulate blood pressure, the first sign of renal artery disease is often high blood pressure. (simstat.com)
- You may be evaluated for kidney artery disease if your doctor notices certain signs during a physical examination or routine blood tests. (simstat.com)
- Diagnosing kidney artery disease early can prevent serious damage to your kidneys and other organs, including the heart. (simstat.com)
- A medical history includes a complete review of any medical conditions you have (especially risk factors for renal artery disease), surgeries and other procedures you've had in the past, and any medications you are taking (including prescription drugs, over-the-counter medications, and dietary supplements). (simstat.com)
- A history of all medications you are taking is also important to diagnose kidney artery disease. (simstat.com)
- In addition to diagnosing kidney artery disease, these imaging tests can also identify problems in nearby blood vessels (such as an aortic aneurysm) and help develop a treatment plan. (simstat.com)
- 4,5 It is not known why renal artery disease is more common in women than men in this population. (hearthealthywomen.org)
- Historically, the term "juvenile nephronophthisis-medullary cystic disease complex" was created to describe two histopathologically similar diseases: familial juvenile nephronophthisis (FJN) and medullary cystic kidney disease (MCKD). (renalandurologynews.com)
- Familial GCKD is typically identified with hypoplastic or normal-sized kidneys. (oncologynurseadvisor.com)
- Familial GCKD can also be associated with hypoplastic or normal-sized kidneys. (oncologynurseadvisor.com)
- In MCKD2, the mutations in uromodulin, the Tamm-Horsfall protein, have been shown to cause not only MCKD but also familial juvenile hyperuricemic nephropathy (FJHN), and glomerulocystic kidney disease (GCKD). (psychiatryadvisor.com)
- A list of familial renal diseases by dog and cat breeds is found below. (wikipedia.org)
Patients with chronic4
- The calcitonin levels can sometimes mislead parathyroid surgeons in patients with chronic kidney disease and renal hyperparathyroidism: report of a. (nih.gov)
- Renal hyperparathyroidism (rHPT) as a consequence of an abnormal calcium balance is a frequent complication in patients with chronic kidney disease (CKD). (nih.gov)
- Whether rates of cardiovascular events and mortality differ among Hispanic and non-Hispanic white patients with chronic kidney disease (CKD) also is not well understood. (nih.gov)
- Danilo Verge, Vice President, Cardiovascular, Renal and Metabolism, Global Medical Affairs at AstraZeneca said: "The data we are presenting at ASN Kidney Week demonstrate our ambition to advance treatment for patients with chronic kidney disease and its associated complications. (astrazeneca-us.com)
- On US imaging, kidneys can appear enlarged with increased echogenicity and loss of cortico-medullary junction differentiation. (oncologynurseadvisor.com)
- Does this patient have medullary cystic kidney disease? (psychiatryadvisor.com)
- Pedigree of a family affected with medullary cystic kidney disease. (psychiatryadvisor.com)
- Avner ED (1994) Medullary cystic disease and medullary sponge kidney. (springer.com)