Renal Agents

Advanced Renal Cell Carc2

• The ongoing phase III ADAPT (The Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma) study is using this approach to personalized immunotherapy, with the goal of randomizing 450 patients. (urologytimes.com)
• CAMBRIDGE, Mass.--( BUSINESS WIRE )--AVEO Oncology (NASDAQ:AVEO) today announced that the first patient has been dosed in the Company's pivotal TIVO-3 trial, a randomized, controlled, multi-center, open-label study to compare tivozanib to sorafenib in subjects with refractory advanced renal cell carcinoma (RCC). (businesswire.com)

Insufficiency5

• Injections of radiocontrast agents are a frequent cause of acute decreases in renal function, occurring most often in patients with chronic renal insufficiency and diabetes mellitus. (nih.gov)
• We prospectively studied 78 patients with chronic renal insufficiency (mean [+/- SD] serum creatinine concentration, 2.1 +/- 0.6 mg per deciliter [186 +/- 53 mumol per liter]) who underwent cardiac angiography. (nih.gov)
• In patients with chronic renal insufficiency who are undergoing cardiac angiography, hydration with 0.45 percent saline provides better protection against acute decreases in renal function induced by radiocontrast agents than does hydration with 0.45 percent saline plus mannitol or furosemide. (nih.gov)
• Obtain blood urea nitrogen (BUN) and creatinine levels to determine the presence of renal insufficiency, as serum magnesium levels rise when the creatinine clearance is less than 30 mL/min. (medscape.com)
• Probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less. (nih.gov)

Impairment5

• A novel antioxidant agent caffeic acid phenethyl ester prevents long-term mobile phone exposure-induced renal impairment in rat. (emf-portal.org)
• Dose adjustment is required for diabetes patients with renal impairment taking combination products containing metformin. (mims.co.uk)
• The guidance on metformin combination preparations reflects the recommended maximum daily metformin dose of 2g/day in patients with moderate renal impairment stage 3a (GFR 45-59ml/min) and 1g/day in patients with stage 3b (GFR 30-45ml/min). (mims.co.uk)
• Probenecid has been used in patients with some renal impairment, but dosage requirements may be increased. (nih.gov)
• Because of its mechanism of action, probenecid is not recommended in conjunction with a penicillin in the presence of known renal impairment. (nih.gov)

Dysfunction3

• However, CHCl3 produced a concentration-related dysfunction when added to renal cortical slices from Fischer 344 or Sprague-Dawley rats. (cdc.gov)
• Contrast agents should not be used in patients with renal dysfunction unless absolutely necessary. (medscape.com)
• and development of several imaging methods that could serve as noninvasive tools for renal and mitochondrial dysfunction, and several drug-companion biomarker pairs for sepsis associated AKI. (nih.gov)

Decrease in renal function2

• An acute radiocontrast-induced decrease in renal function was defined as an increase in the base-line serum creatinine concentration of at least 0.5 mg per deciliter (44 mumol per liter) within 48 hours after the injection of radiocontrast agents. (nih.gov)
• Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine. (msdmanuals.com)

Toxicity3

• Various ketonic agents potentiate the hepatic and renal toxicity of halogenated solvents in mice and rats. (cdc.gov)
• The degree of CHCl3 toxicity in vitro was not altered when renal cortical slices were preincubated with CHCl3 (8.5 microl) under an atmosphere of carbon monoxide. (cdc.gov)
• Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. (pediatriconcall.com)

Metastatic4

• A personalized immunotherapy (AGS-003) nearly doubled expected progression-free survival and overall survival when added to standard sunitinib (Sutent) in patients with unfavorable-risk metastatic renal cell carcinoma, according to results from a single-arm phase II study. (urologytimes.com)
• Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma. (ox.ac.uk)
• This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
• Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

Hepatic2

• Probenecid decreases both hepatic and renal excretion of sulfobromophtalein (BSP). (nih.gov)
• Probenecid decreases both hepatic and renal excretion of sulfobromophthalein (BSP). (nih.gov)

Patients atteints3

• Nous avons enquêté auprès de 188 patients atteints d'une maladie rénale à l'aide de 36 questions à choix multiples dans deux hôpitaux des Émirats arabes unis. (who.int)
• RÉSUMÉ Une alimentation adaptée peut contribuer à lutter contre le syndrome cachectique chez les patients atteints d'une maladie rénale sous dialyse. (who.int)
• La présente étude d'intervention visait à identifier les problèmes de malnutrition et à évaluer l'effet de conseils diététiques sur l'amélioration de l'état de santé des patients atteints d'une maladie rénale en phase terminale soumis à une hémodialyse. (who.int)

Hypertension2

• If trials of antihypertensive drugs are any indication, the first results from randomized trials of renal denervation for resistant hypertension will show smaller reductions in blood pressure compared with those from the unblinded trials, a study in Heart indicated. (medpagetoday.com)
• In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion. (janusinfo.se)

Chronic kidney1

• Chronic Kidney Disease Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. (msdmanuals.com)

Disease6

• These agents are also indicated to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus who with either established cardiovascular disease or multiple cardiovascular risk factors. (medscape.com)
• Outcome Measures in Renal Disease: How Good Are Surrogates? (hdcn.com)
• Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first-line cyclophosphamide, vincristine, and prednisone (CVP) chemotherapy. (drugs.com)
• Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
• This intervention study aimed to identify malnutrition problems and assess the effect of dietary counselling on improvement of health status of end-stage renal disease patients subjected to haemodialysis. (who.int)
• Nutrition tips are tion of baseline data through inter- end-stage renal disease (ESRD) ranges another effective way of providing a views and laboratory reports with patients attending the centre to assess between 34 and 200 per million popula- practical nutrition education message their nutritional status. (who.int)

Pharmacology1

• It's exciting to work with this new imaging agent," noted Dr. Calais, an associate professor at the Ahmanson Translational Theranostics Division of the Department of Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA). (diagnosticimaging.com)

Acute kidney2

• As senior investigator and chief of the Renal Diagnostics and Therapeutics Unit, I lead a team that studies sepsis and acute kidney injury (AKI)-both are associated with high rates of illness and death. (nih.gov)
• 5. Lameire N., Kellum J. Contrast-induced acute kidney injury and renal support for acute kidney injury: a KDIGO summary (Part 2) // Critical Care. (medline.ru)

Intravascular1

• Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial //The Lancet. (medline.ru)

Diabetes1

• Diabetes Mellitus: To minimise the risk of hyperkalaemia in known or suspected diabetic patients, the status of renal function should be determined before initiating therapy. (janusinfo.se)

Tumor3

• We employed spectral imaging in a rodent window chamber model to observe and measure the oxygen transport function of tumor microvasculature in a human renal cell carcinoma after treatment with a fast acting vascular disrupting agent. (spie.org)
• Predictive Nomogram for Recurrence following Surgery for Nonmetastatic Renal Cell Cancer with Tumor Thrombus. (harvard.edu)
• Tumor lysis syndrome: Administer aggressive intravenous hydration, anti-hyperuricemic agents, monitor renal function ( 5.5 ). (drugs.com)

Glomerular1

• Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat a variety of inflammatory diseases, these agents may cause deleterious effects on kidney function, especially with respect to solute homeostasis and maintenance of renal perfusion and glomerular filtration. (nih.gov)

Angiography1

• An augmented patient-specific approach to administration of contrast agent for CT renal angiography. (harvard.edu)

Pulmonary Edema1

• These agents should not be used for myelography or in injections that may enter the spinal canal (because neurotoxicity is a risk) or the bronchial tree (because pulmonary edema is a risk). (msdmanuals.com)

Function3

• Drugs that selectively inhibit COX-2 might, therefore, be expected to produce effects on renal function similar to nonselective NSAIDs which inhibit both COX-1 and COX-2. (nih.gov)
• Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function. (bvsalud.org)
• Contrast Nephropathy Contrast nephropathy is worsening of renal function after IV administration of radiocontrast and is usually temporary. (msdmanuals.com)

Kidney2

• A Simple Trick to Right Renal Vein Elongation in Deceased Donor Kidney Transplantation. (harvard.edu)
• A case of solitary kidney with duplex collecting systems and renal vascular variants in an adult male cadaver. (harvard.edu)

Refractory1

• Relapsed or refractory, low grade or follicular, CD20-positive B-cell NHL as a single agent. (drugs.com)

Heart failure2

• The rapid increase in extracellular volume and cardiac preload caused by hyperosmotic agents may precipitate or aggravate congestive heart failure. (aao.org)
• In congestive heart failure, Amiloride Hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents. (janusinfo.se)

Vasoconstrictor1

• Ornipressin is a vasoconstrictor, haemostatic and renal agent. (wikipedia.org)

Osmotic agent1

• The osmotic agent enters the eye more rapidly when the blood-aqueous barrier is disrupted than when it is intact, reducing the effectiveness of the drug and its duration of action. (aao.org)

Diuretics1

• Of these 3 types of diuretics, loop diuretics have a greater effect on renal magnesium wasting because of their site of action. (medscape.com)

Inhibit1

• Probenecid also has been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17 -ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (nih.gov)

MeSH1

• Renal Veins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

Dosage2

• Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)
• If necessary, dosage of both agents may be increased gradually until there is effective diuresis. (janusinfo.se)

Cancer4

• Conventional imaging doesn't provide sufficient clarity for differentiating between benign renal masses and clear cell renal cell carcinoma (ccRCC), "the deadliest renal cancer and the most frequent one," noted Jeremie Calais, M.D, MSc, during an interview at the recent Society of Nuclear Medicine and Molecular Imaging (SNMMI) conference in Chicago . (diagnosticimaging.com)
• The PSMA PET agent 64Cu SAR-bisPSMA detected a higher number of prostate cancer lesions and had a significantly higher SUVmax and SUVmean than 68Ga PSMA-11 PET/CT, according to initial data from a prospective multisite study presented at the recent Society of Nuclear Medicine and Molecular Imaging (SNMMI) conference. (diagnosticimaging.com)
• Final results from a pivotal clinical trial show that the investigational agent N-803 combined with bacillus Calmette-Guérin (BCG) is safe and more effective than other intravesical and systemic options for high-risk nonmuscle-invasive bladder cancer (NMIBC) that is unresponsive to BCG alone, according to an oral presentation at the 2022 ASCO Annual Meeting. (renalandurologynews.com)
• While significant advances have been made in the treatment of renal cancer, there remains a need for effective yet more tolerable treatments, both for single agent and combination use," said Brian Rini, M.D., Professor of Medicine at the Cleveland Clinic Lerner College of Medicine. (businesswire.com)

Inhibitors2

• I am pleased to see tivozanib return to the clinic, with the goal of better understanding its single agent potential through TIVO-3, and I look forward to realizing its potential for combination use with checkpoint inhibitors in future studies. (businesswire.com)
• It, therefore, seems unlikely that these COX-2 inhibitors (and perhaps their successors) will offer renal safety benefits over nonselective NSAID therapies, and, at this juncture, it is reasonable to assume that all NSAIDs, including COX-2-selective inhibitors, share a similar risk for adverse renal effects. (nih.gov)

Sensitivity1

• 2 cm, the PET/CT agent 89Zr-DFO-girentuximab had respective sensitivity rates of approximately 85 percent and 96.7 percent for diagnosing clear cell renal cell carcinoma, according to research recently presented at the European Association of Nuclear Medicine (EANM) 2023 Congress. (diagnosticimaging.com)

Novel Agents1

• Trials for novel agents for the treatment of tuberculosis (TB) are under way. (medscape.com)

Tissues1

• Radiopaque contrast agents are often used in radiography and fluoroscopy to help delineate borders between tissues with similar radiodensity. (msdmanuals.com)

Adverse1

• Newer nonionic contrast agents are now routinely used at nearly all institutions because they have fewer adverse effects. (msdmanuals.com)

Adult1

• For the ZIRCON study, researchers assessed the use of 89 ZR-DFO-girentuximab (TLX250-CDx, Telix Pharmaceuticals) for ccRCC detection in adult patients with indeterminate renal masses. (diagnosticimaging.com)

Moderate1

• These agents have moderate afterload reduction properties and cause slight preload reduction. (medscape.com)

Injection1

• If contrast is necessary, a nonionic agent should be used, and patients should be premedicated with prednisone (50 mg orally 13 hours, 7 hours, and 1 hour before injection of contrast) and diphenhydramine (50 mg orally or IM 1 hour before the injection). (msdmanuals.com)

Glycerol1

• Common hyperosmotic agents include oral glycerol and intravenous mannitol. (aao.org)

Mild1

• In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred. (nih.gov)

Trials4

• James Howard, MBBChir , of Imperial College London, and colleagues looked at the discrepancy between office-based and ambulatory readings in trials of antihypertensive agents and renal denervation. (medpagetoday.com)
• They included 31 drug trial with 4,121 patients and 23 renal denervation trials with 720 patients. (medpagetoday.com)
• There aren't any results from randomized, blinded trials for renal denervation yet, but in the unblinded trials, office-based systolic blood pressure drops averaged 27.6 mm Hg versus pretreatment values and 26.6 mm Hg versus untreated controls. (medpagetoday.com)
• Since Nocardia species infections are very often sporadic, information from randomized clinical trials comparing the clinical efficacy of specific antimicrobial agents is lacking. (antimicrobe.org)

Treatment3

• In addition, subdural and subarachnoid hemorrhages have been reported after treatment with hyperosmotic agents. (aao.org)
• The company is focused on developing and commercializing its lead candidate tivozanib, a potent, selective, long half-life inhibitor of vascular endothelial growth factor 1, 2 and 3 receptors, in North America as a treatment for renal cell carcinoma and other cancers. (businesswire.com)
• Treatment of monkeypox with tecovirimat as a first-line agent is available through CDC for compassionate use through an investigational drug protocol. (cdc.gov)

Tumour2

• The high vascularity and responsiveness to immunotherapy of renal cell carcinoma (RCC) makes such a tumour a potential target for IM862. (ox.ac.uk)
• For applications, including in the devel- but is required more simply to as- ease of reference, these five agents opment of human tumour profiles to sess the overall weight of the ev- are included in an expanded group assist in the identification of addition- idence in experimental animals. (who.int)

Acid1

• The association of 14CHCl3-derived radiolabel was increased over control by 2-hexanone pretreatment in protein, lipid, and acid soluble fractions from the renal cortex by approximately two-, two-, and fivefold, respectively. (cdc.gov)