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Mammals of the families Delphinidae (ocean dolphins), Iniidae, Lipotidae, Pontoporiidae, and Platanistidae (all river dolphins). Among the most well-known species are the BOTTLE-NOSED DOLPHIN and the KILLER WHALE (a dolphin). The common name dolphin is applied to small cetaceans having a beaklike snout and a slender, streamlined body, whereas PORPOISES are small cetaceans with a blunt snout and rather stocky body. (From Walker's Mammals of the World, 5th ed, pp978-9)
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A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
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A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
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Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Relaxin is a potent renal vasodilator in conscious rats. (1/449)
The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality. (+info)Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. (2/449)
Employing uteroplacental tissue at Day 35 of gestation, we determined the nucleic acid sequence of canine preprorelaxin using reverse transcription- and rapid amplification of cDNA ends-polymerase chain reaction. Canine preprorelaxin cDNA consisted of 534 base pairs encoding a protein of 177 amino acids with a signal peptide of 25 amino acids (aa), a B domain of 35 aa, a C domain of 93 aa, and an A domain of 24 aa. The putative receptor binding region in the N'-terminal part of the canine relaxin B domain GRDYVR contained two substitutions from the classical motif (E-->D and L-->Y). Canine preprorelaxin shared highest homology with porcine and equine preprorelaxin. Northern analysis revealed a 1-kilobase transcript present in total RNA of canine uteroplacental tissue but not of kidney tissue. Uteroplacental tissue from two bitches each at Days 30 and 35 of gestation were studied by in situ hybridization to localize relaxin mRNA. Immunohistochemistry for relaxin, cytokeratin, vimentin, and von Willebrand factor was performed on uteroplacental tissue at Day 30 of gestation. The basal cell layer at the core of the chorionic villi was devoid of relaxin mRNA and immunoreactive relaxin or vimentin but was immunopositive for cytokeratin and identified as cytotrophoblast cells. The cell layer surrounding the chorionic villi displayed specific hybridization signals for relaxin mRNA and immunoreactivity for relaxin and cytokeratin but not for vimentin, and was identified as syncytiotrophoblast. Those areas of the chorioallantoic tissue with most intense relaxin immunoreactivity were highly vascularized as demonstrated by immunoreactive von Willebrand factor expressed on vascular endothelium. The uterine glands and nonplacental uterine areas of the canine zonary girdle placenta were devoid of relaxin mRNA and relaxin. We conclude that the syncytiotrophoblast is the source of relaxin in the canine placenta. (+info)Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. (3/449)
This study examines the endocrine alterations associated with early fetal loss (EFL) induced by an environmental toxin, TCDD (2,3,7, 8-tetrachlorodibenzo-p-dioxin), in the cynomolgus macaque, a well-documented reproductive/developmental model for humans. Females were administered single doses of 1, 2, and 4 microgram/kg TCDD (n = 4 per dose group) on gestational day (GD) 12. Urinary estrogen metabolites (estrone conjugates) were monitored to establish the day of ovulation, and serum hormones (estradiol, progesterone, chorionic gonadotropin, relaxin) were measured to assess ovarian and placental endocrine status before and after treatment. EFL occurred between GDs 22 and 32 in 10 of the 12 animals treated with TCDD. The primary endocrine alterations associated with TCDD treatment were significant decreases in serum estradiol and bioactive chorionic gonadotropin concentrations (p < 0.02). Less pronounced decreases in serum progesterone (p = 0.10) and relaxin (p < 0.08) also followed TCDD treatment. In contrast, immunoreactive chorionic gonadotropin concentrations were not reduced by TCDD exposure at any level, indicating that TCDD targets specific components of the chorionic gonadotropin synthesis machinery within the trophoblast to alter the functional capacity of the hormone. These data demonstrate the value of endocrine biomarkers in identifying a toxic exposure to primate pregnancy many days before direct signs of reproductive toxicity were apparent. The increased EFL that occurred after exposure to TCDD might reflect a toxic response initially mediated via endocrine imbalance, leading to placental insufficiency, compromised embryonic circulation, and subsequent EFL. (+info)Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success. (4/449)
We have developed a cell culture system for human luteinizing granulosa cells which supports the timely and dynamic secretion of oestrogen, progesterone and relaxin in patterns that mimic serum concentrations of these hormones during the luteal phase of the menstrual cycle. There was a wide variation in the amount of relaxin secreted by the cultured cells for the 69 patients studied. As relaxin production was generally maximal by day 10 of culture, comparisons were made at this time point. It was observed that most of the conceptions occurred in patients with higher relaxin secretion in vitro. All cycles with relaxin > 800 pg/ml on day 10 had a term pregnancy while only 13% of cycles with relaxin < 200 pg/ml had term pregnancies. A limited number of cycles from donor/recipient cycles did not show similar results. Steroid concentrations were not predictive of conception. These results demonstrated that in-vitro production of relaxin is predictive of implantation success in in-vitro fertilization (IVF)-embryo transfer cycles. This supports the hypothesis that relaxin may be involved in implantation and that lowered relaxin concentrations may be a partial cause of poor pregnancy rates after IVF. (+info)Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. (5/449)
Although the role of the reproductive hormone, relaxin, in rodents is well documented, its potential contribution to human reproduction is less well defined. In this study, we examine the effects of relaxin on human endometrial cells in vitro and describe the clinical effects of relaxin on menstrual flow in women. In cultured endometrial cells, relaxin specifically induces the expression of an angiogenic agent, vascular endothelial growth factor (VEGF). cAMP is implicated as a second messenger involved in VEGF stimulation. VEGF expression is temporally regulated in the endometrium, and our results suggest that relaxin, which is secreted by the corpus luteum and is present in the endometrium during the menstrual cycle and pregnancy, may be involved in regulating endometrial VEGF expression. Relaxin was recently tested in a clinical trial for efficacy in the treatment of progressive systemic sclerosis, and was administered at levels up to 10 times higher than that measured during pregnancy. The most frequent relaxin-related adverse event reported during the course of the study was the onset of menometrorrhagia, defined in this study as heavier-than-usual or irregular menstrual bleeding. The intensification of menstrual flow observed in these patients is consistent with the hypothesis that relaxin mediates neovascularization of the endometrial lining. (+info)Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells. (6/449)
Human endometrium is the major organ that produces glycodelin A (GdA). The production of endometrial GdA causes a fluctuation of the peripheral glycodelin concentrations in women during the menstrual cycle and pregnancy. It has recently been reported that the rise of plasma concentrations of glycodelin is correlated with relaxin during the late luteal phase and early pregnancy. In addition, administration of relaxin increases glycodelin plasma concentrations, suggesting that relaxin induces GdA production in endometrium. To investigate whether relaxin regulates the GdA synthesis, human endometrial glandular epithelial cells were isolated and cultured with or without relaxin for up to 4 days. Western blot showed that GdA synthesized and secreted from epithelial glands had a major molecular weight of 28 kDa, i.e. the same as the GdA isolated from amniotic fluid. Cells incubated with relaxin consistently increased in GdA production rate (2-6-fold). The GdA mRNA concentrations increased 2-11-fold in cells incubated with relaxin for 2-4 days, as determined by solution hybridization/ribonuclease protection assay. The increase of the mRNA concentration indicates that relaxin activates GdA transcription. (+info)What knockout mice can tell us about parturition. (7/449)
Many molecules, including steroid and peptide hormones, prostaglandins and cytokines, regulate the preparation, initiation and progression of parturition in mammals. Gene targeting studies show that, in the knockout mice of steroid 5alpha-reductase type 1 gene, prostaglandin F2alpha receptor gene and cytosolic phospholipase A2 gene, parturition was severely disturbed, although live offspring were delivered by Caesarean section. Relaxin gene-disrupted mice also showed protracted labour. However, most knockout mice in which the steroid hormone, prostaglandin, cytokine or peptide hormone (for example, oxytocin, corticotrophin releasing hormone and endothelin) endocrine-paracrine systems are disrupted are inadequate for analysis of the mechanism of parturition because they die before reaching reproductive age or are infertile, or because they reproduce normally. A conditional knockout strategy, for example, using the Cre-LoxP system, should be considered for investigating the biochemical background of parturition to overcome these problems. (+info)Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment. (8/449)
The binding characteristics of the relaxin receptor in rat atria, uterus and cortex were studied using a [33P]-labelled human gene 2 relaxin (B33) and quantitative receptor autoradiography. The binding kinetics of [33P]-human gene 2 relaxin (B33) were investigated in slide-mounted rat atrial sections. The binding achieved equilibrium after 60 min incubation at room temperature (23+/-1 degrees C) and dissociated slowly. The association and dissociation rate constants were 4.31+/-0.34x10(8) M(-1) x min(-1) and 1.55+/-0.38x10(-3) min(-1) respectively. Thus, the kinetic dissociation constant was 3.46+/-0.59 pM. Binding was saturable to a single population of non-interacting sites throughout atria, in uterine myometrium and the 5th layer of cerebral cortex. The binding affinities (pK(D)) of [33P]-human gene 2 relaxin (B33) were 8.92+/-0.09 in atrial myocardium and 8.79+/-0.04 in cerebral cortex of male rats, and 8.79+/-0.10 in uterine myometrium. Receptor densities in the cerebral cortex and atria were higher than in uterine myometrium, indicating that relaxin also has important roles in non-reproductive tissues. In male rats, treatment with 17beta-oestradiol (20 microg in 0.1 ml sesame oil s.c., 18-24 h) significantly decreased the density of relaxin receptors in atria and cerebral cortex. Identical treatment in female rats had no significant effect in atria and cerebral cortex, but it significantly increased the density of relaxin receptors in uterine myometrium. Relaxin binding was competitively displaced by porcine and rat native relaxins. Porcine native relaxin binds to the relaxin receptor in male rat atria (8.90+/-0.02), and cerebral cortex (8.90+/-0.03) and uterine myometrium (8.89+/-0.03) with affinities not significantly different from human gene 2 (B33) relaxin. Nevertheless, rat relaxin binds to the receptors with affinities (8.35+/-0.09 in atria, 8.22+/-0.07 in cerebral cortex and 8.48+/-0.06 in uterine myometrium) significantly less than human gene 2 (B33) and porcine relaxins. Quantitative receptor autoradiography is the method of choice for measurement of affinities and densities of relaxin receptor in atria, uterine myometrium and cerebral cortex. High densities were found in all these tissues. 17beta-oestradiol treatment produced complex effects where it increased the densities of relaxin receptors in uterus but decreased those in atria and cerebral cortex of the male rats, and had no effect on the atria and cerebral cortex of the female rats. (+info)
Biology of primate relaxin: A paracrine signal in early pregnancy? | Reproductive Biology and Endocrinology | Full Text
Abstract 12961: No Effect of Hepatic Impairment on the Pharmacokinetics of Serelaxin, a Recombinant Human Relaxin-2 in...
RELAXIN INHIBITS SPONTANEOUS AND PROSTAGLANDIN-DRIVEN MYOMETRIAL ACTIVITY IN ANAESTHETIZED RATS in: Journal of Endocrinology...
KEGG PATHWAY: hsa04926
DiVA - Search result
Brainstem nucleus incertus controls contextual memory formation<...
Hot Off the Press: Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimers disease patients ...
Effect of relaxin on human sperm functions. - MyScienceWork
Scientific rationale and design of a phase I safet - Welcome to the Preeclampsia Foundation
Oral Presentation - ASN Events
Pelvic pain in pregnancy : Studies on symphyseal distension, serum relaxin levels and the influence of living conditions
Baby London: Your post baby body by Camilla Lawrence | Six Physio
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Treating Fibromyalgia with Relaxin
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IDEALS @ Illinois: Evidence That Relaxin Promotes Cellular Proliferation in the Lower Reproductive Tract of the Pregnant Rat
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Your Growing Baby In Your Third Trimester - Maternitys
Category: Exercise Guidelines - Elina Physical Therapy
Kirk P. Conrad, M.D. » Department of Physiology and Functional Genomics » College of Medicine » University of Florida
Relaxin regulates endometrial structure and function in the rhesus monkey.
Identification of INSL5, a new member of the insulin superfamily
Remarkable Benefits of the Nutrient Relaxin - Naturals Pro
Relaxin H2 (human) H-6784 | Bachem
Characterization, cDNA cloning and expression pattern of relaxin gene during embryogenesis of Danio rerio.
Papers in the shared collection Acute Heart Failure | Read by QxMD
Hard Gainers and Relaxin levels (Page 4) - Thunders Place
US Patent # 4,871,670. Molecular cloning and characterization of a gene sequence coding for
human relaxin - Patents.com
Your pregnancy hormones, explained
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Pregnancy Hormones
Relaxin - Alchetron, The Free Social Encyclopedia
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Pregnancy Hormones - Everything You Need To Know
RLN3 - Relaxin-3 precursor - Homo sapiens (Human) - RLN3 gene & protein
rat RLN3 protein
Summary Report | CureHunter
Relaxin is essential for renal vasodilation during pregnancy in conscious rats
Sequence Detail
Membrane Target Systems: Relaxin RXFP3 (human) membrane preparation, in CHO-K1 cells. 400 Units. | PerkinElmer
Relaxin activates peroxisome proliferator-activated receptor γ(PPAR γ)through a pathway involving PPAR γ coactivator 1α (PGC1α)...
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The World of Copepods - Bryocamptus incertus Borutsky, 1932
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Pelvic girdle pain
Relaxin hormone[edit]. Relaxin is a hormone produced mainly by the corpus luteum of the ovary and breast, in both pregnant and ... European Research has determined that relaxin levels are not a predictor of PGP during pregnancy.[14][15][16][17] ... The body produces relaxin during menstruation that rises to a peak within approximately 14 days of ovulation and then declines ... During pregnancy relaxin has a diverse range of effects, including the production and remodelling of collagen thus increasing ...
Ah W Noss
It was released on April 14, 2004 by Relax-In and Megastar Records. This was the follow-up project to 2003's Ya Salam. In 2003 ... Relax-In/Megastar. 7243 576650 2 5. "Nancy Nabil Ajram". Welcome Qatar. "شكوى من فوضى تنظيمية ضاربة في حفل جوائز الموسيقى ...
Nancy Ajram videography
Relax-in/Megastar. 2003.CS1 maint: others in cite AV media (notes) (link) Ah W Noss (inlay cover). Nancy Ajram. Relax-in/ ...
Ya Salam
It was released on February 24, 2003 by Relax-In and Megastar. Ajram worked with all new collaborations, including Tarek ... Relax-In/Megastar. 07243 581682 2 8. "Lebanese pop singer Nancy Ajram displays her troph". Getty Images. "جائزة "أصغر فنانة"". ...
Juiceboxxx
"G-Side (2) - Relaxin'". Discogs. Retrieved 2019-06-05. Galil, Leor. "Milwaukee Rapper Juiceboxxx Takes His Brand to the Thunder ... Juiceboxxx founded the Thunder Zone Entertainment label in 2011, releasing a seven-inch vinyl single, Relaxin', by G-Side with ...
Florey Institute of Neuroscience and Mental Health
... and the Relaxin hormone. Previously known as the Howard Florey Institute of Experimental Physiology and Medicine, in 1997 the ...
Alastair MacLennan (obstetrician)
"The role of the hormone Relaxin on human reproduction" which is the title of his MD thesis (University of Glasgow, awarded 1985 ... Progress in Relaxin Research. Singapore: Global Publications. ISBN 978-9-813049-02-4. MacLennan AH; Sturdee DW (2008). The ...
Bradykinin
Relaxin. *Agonists: Insulin-like factor 3. *Relaxin (1, 2, 3). *Serelaxin. Somatostatin. *See here instead. ...
Insulin-like growth factor 2
Relaxin family. Insulin and Insulin-like growth factor. *IGF1. *IGF2. Relaxin family peptide hormones. *INSL3 ...
Corticotropin-releasing hormone receptor 2
Relaxin. *Agonists: Insulin-like factor 3. *Relaxin (1, 2, 3). *Serelaxin. Somatostatin. *See here instead. ...
Cholecystokinin B receptor
Relaxin. *Agonists: Insulin-like factor 3. *Relaxin (1, 2, 3). *Serelaxin. Somatostatin. *See here instead. ...
Parathyroid hormone-related protein
Relaxin. *Agonists: Insulin-like factor 3. *Relaxin (1, 2, 3). *Serelaxin. Somatostatin. *See here instead. ...
List of Final Fantasy compilation albums
"POTION 2: Relaxin' with Final Fantasy: Review by Scherzo". Square Enix Music Online. Archived from the original on 2012-02-08. ... "Potion: Relaxin' with Final Fantasy". RPGFan. Archived from the original on 2013-01-16. Retrieved 2008-04-22. Greening, Chris ... "Potion 2: Relaxin' with Final Fantasy". RPGFan. Archived from the original on 2013-01-16. Retrieved 2008-04-22. Philip. " ...
1989 Football League Second Division play-off Final
Ridley, Ian (31 May 1989). "Mackay's relaxant". The Guardian. p. 18. Archived from the original on 18 January 2021. Retrieved ...
Platelet-derived growth factor
Relaxin family. Insulin and Insulin-like growth factor. *IGF1. *IGF2. Relaxin family peptide hormones. *INSL3 ...
Alkaloid
muscle relaxant Vinblastine, vincristine antitumor Vincamine vasodilating, antihypertensive Yohimbine stimulant, aphrodisiac ...
Serelaxin
Relaxin binding to endothelial B receptor on endothelial cells also induces vasodilation. Relaxin causes vasodilation by an ... Relaxin also functions as a cardiac stimulant. Studies have demonstrated that relaxin increases calcium sensitivity of cardiac ... Thus relaxin and serelaxin can increase stroke volume, the amount of blood pumped per heart beat, without increasing the energy ... Relaxin can also bind to a secondary receptor, endothelial B receptor,[clarification needed] which is upregulated as a result ...
Electrical muscle stimulation
The FDA informed owners of Relax-A-Cizors that second-hand sale of Relax-A-Cizors was illegal, and recommended that they should ... The Relax-A-Cizor was one brand of device manufactured by the U.S. company Relaxacizor, Inc. From the 1950s, the company ... Relax-A-Cizors had from 1 to 6 channels. Two pads (or electrodes) were connected by wires to each channel. The user applied ... The case went to court, and the United States District Court for the Central District of California held that the Relax-A-Cizor ...
Tubocurarine chloride
Succinylcholine is a widely used muscle relaxant drug which acts by activating, instead of blocking, the ACh receptor. The ... Thompson MA (1980). "Muscle relaxant drugs". Br J Hosp Med. 23 (2): 153-4, 163-4, 167-8 passim. PMID 6102875. Page 151 in: Rang ...
The Leopard
The Princess relaxes. The next morning, the Prince, in the company of his usual morning companions, Don Ciccio (the parish ...
Assassination of Mahmoud Al-Mabhouh
Al-Mabhouh was injected in his leg with succinylcholine, a quick-acting, depolarizing paralytic muscle relaxant.[54] It causes ...
INSL3
Tomboc M, Lee PA, Mitwally MF, Schneck FX, Bellinger M, Witchel SF (November 2000). "Insulin-like 3/relaxin-like factor gene ... Büllesbach EE, Rhodes R, Rembiesa B, Schwabe C (April 1999). "The relaxin-like factor is a hormone". Endocrine. 10 (2): 167-9. ... Hombach-Klonisch S, Buchmann J, Sarun S, Fischer B, Klonisch T (December 2000). "Relaxin-like factor (RLF) is differentially ... "A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism". Pediatric Research. 47 ...
Hip dysplasia
Specifically, the hormone relaxin has been indicated. A genetic factor is indicated since the trait runs in families and there ... Forst J, Forst C, Forst R, Heller KD (1997). "Pathogenetic relevance of the pregnancy hormone relaxin to inborn hip instability ...
Matt Carson
Adam Russell (October 2, 1997). "Administration relaxes Pit rules". The Daily Athenaeum. Thomas Heath (November 27, 2011). "A ...
Vec
... uronium, a muscle relaxant. vec, a sentient moravec robot from the Orion's Arm Universe Project (see also Moravec_(robot)) ...
Indianapolis Museum of Art
Pes, Javier (April 2010). "Indianapolis Relaxes Climate Controls". The Art Newspaper. Pes, Javier (June 2, 2010). "Climate ...
Chit Khaing
"Burma Relaxes Banking Regulations". The Irrawaddy. 14 June 2010. Retrieved 29 October 2012. "Commission Regulation (EU) No 411/ ...
Maria Holbură
It relaxes me extraordinarily." Holbură made her international debut at the 2014 International Gymnix in Montreal where she ...
Alive (Chick Corea album)
Relaxin' at Camarillo (1979). *Mirror Mirror (1980). *Joe Henderson: Big Band (1997) ...
Prostaglandin receptor
relaxant. Gs alpha subunit. stimulates AC & PKA; raises cAMP Thromboxane A2 receptor. TP. TXA=PGH2,,PGD2=PGE2=PGF2α=PGI2[14]. ... relaxant. Gs alpha subunit. activates AC, increases cAMP, raises Ca2+ Prostaglandin DP2 receptor. DP2. PGD2,,PGF2α=PGE2,PGI2= ... relaxant. Gs alpha subunit. stimulates AC, raises cAMP, stimulates beta catenin and Glycogen synthase kinase 3 ... relaxant. Gs alpha subunit. stimulates AC, PKA, PI3K, AKT, ERK, p38 Mpk, & CREB; raises cAMP ...
relaxin - Wiktionary
Muscle relaxant - Wikipedia
"muscle relaxant." mediLexicon. (c) 2007. Retrieved on September 19, 2007. *^ "Muscle relaxants." WebMD. Last Updated: February ... A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate ... "Skeletal Muscle Relaxant (Oral Route, Parenteral Route)." Mayo Clinic. Last Updated: April 1, 2007. Retrieved on September 19, ... See S, Ginzburg R (2008). "Choosing a skeletal muscle relaxant". Am Fam Physician. 78 (3): 365-370. ISSN 0002-838X. PMID ...
Relaxin - Wikipedia
Relaxin family peptide hormones Insulin/IGF/Relaxin family Relaxin/insulin-like family peptide receptor 1 Bani D (January 1997 ... Relaxin 1 and relaxin 2 arose from the duplication of a proto-RLN gene between 44.2 and 29.6 million years ago in the last ... Relaxin increases the rate and force of cardiac contraction in rat models. Via upregulation of VEGF, relaxin plays a key role ... Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw. The relaxin-like peptide family ...
Relaxin-3 - Wikipedia
Relaxin family peptide hormones Insulin/IGF/Relaxin family Relaxin Relaxin/insulin-like family peptide receptor 1 Bathgate, ... Relaxin-3 is a member and ancestral gene of the relaxin family of peptides, which includes the namesake hormone relaxin ( ... The cognate receptor for relaxin-3 is the G-protein coupled receptor RXFP3 (relaxin family peptide 3 receptor), however relaxin ... "Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family". The Journal ...
muscle relaxant (CHEBI:51371)
R)-methocarbamol (CHEBI:77501) has role muscle relaxant (CHEBI:51371). (S)-glaucine (CHEBI:5373) has role muscle relaxant ( ... azumolene (CHEBI:143225) has role muscle relaxant (CHEBI:51371). baclofen (CHEBI:2972) has role muscle relaxant (CHEBI:51371). ... pridinol (CHEBI:75247) has role muscle relaxant (CHEBI:51371). quinine (CHEBI:15854) has role muscle relaxant (CHEBI:51371). ... alcuronium (CHEBI:55313) has role muscle relaxant (CHEBI:51371). alprazolam (CHEBI:2611) has role muscle relaxant (CHEBI:51371) ...
Happy Dog Relaxes in Hammock [Video]
India Relaxes
Magazine Rules - WSJ
Relaxin Protects Astrocytes from Hypoxia In Vitro
Astrocytes that were treated with relaxin-2 and relaxin-3 showed a marked decrease in ROS production when compared to control ... Mitochondrial membrane potential was higher in astrocytes that were treated with relaxin-2 and relaxin-3 compared to untreated ... Cultured astrocytes were pre-treated with either relaxin-2 or relaxin-3 and exposed to OGD for 24 or 48 hours. Following OGD ... Next, to test whether relaxin reduced the production of reactive oxygen species (ROS) astrocytes were exposed to the same ...
Relaxin - Medical Dictionary / Glossary | Medindia
Relaxin - A hormone produced during pregnancy which relaxes the pelvic ligaments and other joints in the body, is clearly ... Medical Word - Relaxin. Ans : A hormone produced during pregnancy which relaxes the pelvic ligaments and other joints in the ... Relaxin - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review Team on May ...
Relaxin 2000 | SpringerLink
The first international forum on relaxin was a workshop held in Hawaii in 1980. This was followed by the Kroc Foundation ... Identification of relaxin and relaxin responsive cells in the rat brain Tanya C. D. Burazin, Pamela J. Davern, Michael J. ... Relaxin 2000. Proceedings of the Third International Conference on Relaxin & Related Peptides 22-27 October 2000, Broome, ... We were therefore delighted to welcome many colleagues, old and new, at Relaxin 2000, the first international forum on relaxin ...
Witness Relaxin (Canada) for Animal Use - Drugs.com
Learn about Witness Relaxin (Canada) for animal usage including: active ingredients, directions for use, precautions, and ... Relaxin is first detectable by WITNESS® RELAXIN during the fourth week of pregnancy (from D22 to D28 after ovulation), reaches ... Witness Relaxin (Canada). This page contains information on Witness Relaxin for veterinary use.. The information provided ... Colloidal gold particles sensitized with an anti-Relaxin antibody bind to Relaxin molecules present in the sample. ...
Morissette relaxes in Brazil, swims with dolphins
CENTRAL FLORIDA RELAXES A BIT - Orlando Sentinel
After being battered by Charley and beaten by Frances, Central Florida looks as if it might escape the brunt of Hurricane Ivan. With forecasts suggesting the storm will target the Panhandle, officials and residents here cautiously exhaled Sunday and contemplated a week without falling branches, power outages and canceled classes.
Taiwan Relaxes Trade Restrictions With China - WSJ
Pakistan Relaxes Import Restrictions on Indian Goods
Synonyms of muscle relaxant | FactMonster
Relaxin
... see Relaxin with the Miles Davis Quintet. Relaxin 1 Identifiers Symbol RLN1 Entrez 6013 HUGO 10026 OMIM 179730 Other data ... In the male, relaxin is produced in the testes. Structure. Structurally, relaxin is a heterodimer of two peptide chains of 24 ... For the Miles Davis album, see Relaxin with the Miles Davis Quintet. Relaxin 1 ... Relaxin interacts with the relaxin receptor LGR7 (RXFP1) and LGR8 (RXFP2) which belong to the G-protein-coupled receptor ...
Treating Fibromyalgia with Relaxin
... discusses his clinical observations of fibromyalgia in female patients and his subsequent discovery that the hormone relaxin is ... There are relaxin receptor sites within the cardiac muscles that relaxes the cardiac muscles. The deficit of relaxin might be ... Relaxin in the Reproductive Cycle Relaxin is well known as an agent for remodeling of the reproductive tract, collagen ... Role of Relaxin Relaxin [the key ingredient in Vitalaxin] has a diverse range of effects, including the production and ...
Day, Son & Hewitt Relaxin
Hewitt Relaxin is available online with fast delivery from VioVet, the trusted supplier of veterinary medication, foods and ... Relaxin® is a blend of nutrients that help to reduce anxiety and promote calmness, relaxation and concentration. Relaxin® is ... Relaxin® should be fed long term to supplement a balanced diet:. If the horse is already receiving a balanced diet, feed ... In situations such as these Relaxin® is particularly useful in keeping the horse as calm and stress-free as possible. ...
Zambia relaxes restrictions as cholera outbreak slows - Reuters
Relaxin - Simple English Wikipedia, the free encyclopedia
Relaxin adjusts blood supply during pregnancy. It also relaxes pelvic ligaments.[2] It softens the pubic symphysis (the ... In animals, relaxin widens the pubic bone and facilitates labor. It also softens the cervix (cervical ripening), and relaxes ... Thus, for a long time, relaxin was looked at as a pregnancy hormone. However, its significance may reach much further. Relaxin ... Bani D (1997). "Relaxin: a pleiotropic hormone.". General pharmacology 28 (1): 13-22. doi:10.1016/s0306-3623(96)00171-1. PMID ...
Halfbakery: muscle relaxant insecticide
muscle relaxant insecticide. muscle relaxant peptides exist, use them to slackercize insect bodies into not eating or ... Botox-like muscle relaxant peptides [link] (they have them in bulk at alibaba.com) could be insecticides, possibly relaxing the ... It might also be possible to block reproduction with muscle relaxant peptides. As peptides these short amino acid sequences ... A nifty possibility is that insect muscle relaxant peptides might be completely different from mammal/human peptides making ...
Relaxin and Related Peptides | The New York Academy of Sciences
This volume contains a description of recent advances and future research and clinical possibilities in the field of relaxin ... In these species relaxin also promotes growth and development of the mammary apparatus. Recently, biological effects of relaxin ... In 2002, a second form of relaxin, which is found primarily in the brain, was discovered. Relaxin-like factor (also called ... The recent identification of the receptors for both relaxin and relaxin-like factor has enabled more rigorous studies of the ...
China relaxes curbs on foreign financial stakes | Financial Times
South Korea relaxes apology demand for nuclear talks - Reuters
FCC Ignores Public, Relaxes Media Ownership - Slashdot
Anti-Relaxin 1 antibody (ab70803) | Abcam
Rabbit polyclonal Relaxin 1 antibody. Validated in WB and tested in Mouse, Rat. Cited in 1 publication(s). Immunogen ... Primary - Rabbit Anti-Relaxin 1 antibody (ab70803) WB Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P, WB, ELISA, ... Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved ... Cardoso LC et al. Locally produced relaxin may affect testis and vas deferens function in rats. Reproduction 139:185-96 (2010 ...
Skeletal Muscle Relaxant
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Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. - PubMed - NCBI
BEA caused a significant decrease in creatinine clearance, which was partially prevented by relaxin. In the relaxin-treated BEA ... In rodent models of pulmonary and dermal fibrosis, relaxin reduced interstitial fibrosis. To study relaxins effect in renal ... Relaxin decreases renal interstitial fibrosis and slows progression of renal disease.. Garber SL1, Mirochnik Y, Brecklin CS, ... Relaxin may have a useful application in decreasing interstitial fibrosis and thereby slowing the progression of renal disease. ...
EPO - T 0272/95 (Relaxin/HOWARD FLOREY INSTITUTE) of 23.10.2002
Claims 18 to 24 were directed to H2-relaxin in various forms or to polypeptides having relaxin activity. ... based on the protein sequences of rat or porcine relaxin since the sequence of human relaxin was not known. Thus, there existed ... T 0272/95 (Relaxin/HOWARD FLOREY INSTITUTE) of 23.10.2002. European Case Law Identifier:. ECLI:EP:BA:2002:T027295.20021023. ... for making a fusion protein comprising relaxin, and for synthesizing H2-relaxin, respectively. ...
PeptidesReceptorReceptorsRecombinant Human RelaxinGeneLGR7RLN1AntibodyRole of RelaxinPregnancy2002Protein2020GenesEffect of relaxinEffects of relaxinActions of relaxinFunction of relaxinEnhances motility of spermLigamentsCervixAntibodiesInsl7Witness RelaxinHormone relaxinRXFP1UterineSpeciesCardiovascularEstrogenSerumRXFP3SerelaxinRatsMRNAFibrosis2001SequenceOvarianSkeletalMatrix metalloproteinasesVascularSynthesisBiologicalFragmentOvariesTrophoblastEndometriumFamily
Peptides18
- Relaxin-3 is a member and ancestral gene of the relaxin family of peptides, which includes the namesake hormone relaxin (designated 'H2 relaxin' in humans) which mediates peripheral actions during pregnancy and which was found to relax the pelvic ligament in guinea pigs almost a century ago. (wikipedia.org)
- However, relaxin and other relaxin family peptides are now associated with numerous non-reproductive physiologies and disease states. (nih.gov)
- Combined with the discovery of the relaxin family peptide receptors, interest in the role of the relaxin family peptides in the central nervous system has been reignited. (nih.gov)
- This review explores the relaxin family peptides that are expressed in or act upon the brain, the receptors that mediate their actions, and what is currently known of their functions. (nih.gov)
- Botox-like muscle relaxant peptides [link] (they have them in bulk at alibaba.com) could be insecticides, possibly relaxing the muscles at insect mouthparts or causing GI tract smooth muscle not to move, killing, starving, or removing motional transport (slackening limbs) at the insect. (halfbakery.com)
- It might also be possible to block reproduction with muscle relaxant peptides. (halfbakery.com)
- Also, possible application to silviculture and arborculture as well as agriculture with trees producing muscle relaxant peptides at bark and sap. (halfbakery.com)
- A nifty possibility is that insect muscle relaxant peptides might be completely different from mammal/human peptides making this even safer. (halfbakery.com)
- This volume contains a description of recent advances and future research and clinical possibilities in the field of relaxin and related peptides. (wiley.com)
- Part I: Relaxin and Related Peptides: Structure and Function. (wiley.com)
- 1. Structure and Activity in the Relaxin Family of Peptides (Geoffrey Tregear et al. (wiley.com)
- 2. The Chemical Synthesis of Relaxin and Related Peptides: A Historical Perspective (John D. Wade et al. (wiley.com)
- 3. De Novo Design and Synthesis of Cyclic and Linear Peptides to Mimic the Binding Cassette of Human Relaxin (Mohammed Akhter Hossain et al. (wiley.com)
- 7. Degradation of Relaxin Family Peptides by Insulin-Degrading Enzyme (Robert Bennett et al. (wiley.com)
- We offer Relaxin R2/LGR8 Peptides and Relaxin R2/LGR8 Proteins for use in common research applications. (novusbio.com)
- Our Relaxin R2/LGR8 Peptides and Relaxin R2/LGR8 Proteins can be used in a variety of model species: Human. (novusbio.com)
- Relaxin-like peptides (RLN/INSL) play diverse roles in reproductive and neuroendocrine processes in placental mammals and are functionally associated with two distinct types of receptors (RXFP) for each respective function. (hindawi.com)
- Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization," Frontiers in Chemistry , vol. 1, article 30, 2013. (hindawi.com)
Receptor16
- The cognate receptor for relaxin-3 is the G-protein coupled receptor RXFP3 (relaxin family peptide 3 receptor), however relaxin-3 is pharmacologically able to also cross react with RXFP1 and RXFP3 (although the physiological relevance of such interactions, if they exist endogenously, are currently unknown). (wikipedia.org)
- Relaxin interacts with the relaxin receptor LGR7 ( RXFP1 ) and LGR8 ( RXFP2 ) which belong to the G-protein-coupled receptor superfamily . (bionity.com)
- Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity). (uniprot.org)
- There is a relaxin receptor binding motif (shown in red and green). (atlasgeneticsoncology.org)
- 6. Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7 (Changlu Liu et al. (wiley.com)
- 9. Structural Basis of Allosteric Ligand-Receptor Interactions in the Insulin/Relaxin Peptide Family: Implications for other receptor Tyrosine Kinases and G Protein-Coupled Receptors (Pierre De Meyts et al. (wiley.com)
- Relaxin also significantly inhibits endometrial levels of estrogen receptor alpha and significantly inhibits levels of progesterone isoforms B and A. The findings that relaxin stimulates new blood vessel formation while maintaining endometrial connective tissue integrity are consistent with a significant role of relaxin in the establishment and/or maintenance of early pregnancy. (biomedsearch.com)
- Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) m. (biomedsearch.com)
- Effects of the sucking stimulus on relaxin receptor (LGR7) expression in the mammary apparatus of th. (biomedsearch.com)
- Immunolocalization indicates that relaxin-receptor complexes may have important roles in boar reproduction and that spermatozoa are already exposed to relaxin upon their production. (unboundmedicine.com)
- Relaxin/insulin-like family peptide receptor 3 , also known as RXFP3 , is a human G-protein coupled receptor . (wikidoc.org)
- Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin," Biochemistry , vol. 46, no. 18, pp. 5374-5381, 2007. (hindawi.com)
- Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone," Biochemical and Biophysical Research Communications , vol. 420, no. 2, pp. 253-256, 2012. (hindawi.com)
- Relaxin Receptor 2 is a member of the Relaxin Receptor subfamily. (genetex.com)
- Relaxin Receptor 2 has been shown to be important for testis descent. (genetex.com)
- The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. (genetex.com)
Receptors7
- Relaxin receptors have been found in the heart , smooth muscle, the connective tissue , and central and autonomous nervous system . (bionity.com)
- The recent identification of the receptors for both relaxin and relaxin-like factor has enabled more rigorous studies of the target tissues and mechanisms of action of these hormones. (wiley.com)
- Part II: Relaxin Family Receptors. (wiley.com)
- 10. Dimerization and Negative Cooperativity in the Relaxin Family Peptide (RXFP) Receptors (Angel Svendsen et al. (wiley.com)
- Relaxin-2 confers its activity by binding to leucine-rich guanine nucleotide-binding (G-protein) coupled receptors, LGR7 and LGR8. (rndsystems.com)
- Here, we assessed the longitudinal distribution of relaxin and its receptors RXFP1 and RXFP2 in the reproductive tract, sex accessory glands, and spermatozoa of adult boars. (unboundmedicine.com)
- The entire sperm length was immunopositive to both relaxin and receptors, with relaxin signal being robust in the acrosome area and RXFP2, homogeneously distributed than RXFP1 on the head of ejaculated spermatozoa. (unboundmedicine.com)
Recombinant Human Relaxin3
- Pilot clinical data suggest that recombinant human relaxin may be effective in treating patients with decompensated CHF. (clinicaltrials.gov)
- Participants receive recombinant human relaxin (rhRlx) via continuous IV infusion for 48 hours at a rate of 100 µg/kg/day (corresponding to a dose of 4.2 µg/kg/hr). (clinicaltrials.gov)
- Recombinant human relaxin (rhRlx) diluted for continuous IV infusion. (clinicaltrials.gov)
Gene8
- Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. (wikipedia.org)
- In 2002, the ancestral relaxin gene RLN3 was identified from genome databases. (nih.gov)
- I. European patent No. 0 112 149 with the title 'Molecular cloning and characterization of a further gene sequence coding for human relaxin' was maintained by the opposition division on the basis of the granted claims. (epo.org)
- The protein encoded by this gene is a member of the relaxin family. (abcam.com)
- Relaxin 1 and Relaxin 2 arose from the duplication of a proto-RLN gene between 44.2 and 29.6 million years ago in the last common ancestor of catarrhine primates. (wikidoc.org)
- Although insulin and H2 relaxin are similar, there is no report that the insulin gene possess an intron. (atlasgeneticsoncology.org)
- It is assumed that the members of the relaxin-gene family are predominantly functional mutations of an original relaxin gene (RLN3) located on chromosome 19 at 19p13.3 and translocated at some stage predominantly to chromosome 9. (atlasgeneticsoncology.org)
- The gene that encodes the human Relaxin 1 protein maps to chromosome 9. (scbt.com)
LGR71
- Relaxin R1/LGR7 Monoclonal antibody specifically detects Relaxin R1/LGR7 in Human, Mouse, Rat samples. (fishersci.com)
RLN11
- In the human there are three non allelic relaxin genes, RLN1, RLN2 and RLN3. (abcam.com)
Antibody1
- Colloidal gold particles sensitized with an anti-Relaxin antibody bind to Relaxin molecules present in the sample. (drugs.com)
Role of Relaxin1
- The role of relaxin in human endometrial function has not been well understood because of the paucity of in vivo studies in women or in suitable primate models. (biomedsearch.com)
Pregnancy23
- Relaxin levels rise to a peak within approximately 14 days of ovulation, and then decline in the absence of pregnancy, resulting in menstruation. (wikipedia.org)
- During the first trimester of pregnancy, levels rise and additional relaxin is produced by the decidua. (wikipedia.org)
- Relaxin mediates the hemodynamic changes that occur during pregnancy, such as increased cardiac output, increased renal blood flow, and increased arterial compliance. (wikipedia.org)
- Via upregulation of VEGF, relaxin plays a key role in blood vessel formation (angiogenesis) during pregnancy, tumour development or ischaemic wounds. (wikipedia.org)
- citation needed] Thus, for a long time, relaxin was looked at as a pregnancy hormone. (wikipedia.org)
- In horses (Equus caballus), relaxin is also an important hormone involved in pregnancy, however, before pregnancy occurs, relaxin is expressed by ovarian structures during the oestrous cycle. (wikipedia.org)
- During early pregnancy, the preimplantation conceptus will express relaxin, which will promote angiogenesis in the endometrium by up-regulating VEGF. (wikipedia.org)
- A hormone produced during pregnancy which relaxes the pelvic ligaments and other joints in the body. (medindia.net)
- Is relaxin the "elusive" vasodilator of pregnancy? (springer.com)
- WITNESS ® RELAXIN is intended to determine pregnancy in the bitch and queen, as well as to distinguish between pseudopregnancy and real gestation in the bitch. (drugs.com)
- Relaxin is first detectable by WITNESS ® RELAXIN during the fourth week of pregnancy (from D22 to D28 after ovulation), reaches its highest level in the 6th-8th weeks, and then declines prior to parturition. (drugs.com)
- It was through this search that I came to a little known pregnancy hormone called relaxin which is produced ten times higher during pregnancy in most mammals. (prohealth.com)
- Relaxin [the key ingredient in Vitalaxin] has a diverse range of effects, including the production and remodeling of collagen, increase in elasticity and relaxation of muscles, tendons and ligaments during pregnancy, particularly in the pelvis. (prohealth.com)
- Since its discovery in the 1920s, relaxin has enjoyed a reputation as a peptide hormone of pregnancy. (nih.gov)
- During the first three months of pregnancy, levels rise and more relaxin is produced. (wikipedia.org)
- Relaxin adjusts blood supply during pregnancy. (wikipedia.org)
- Relaxin is a protein hormone, produced and secreted during pregnancy in mammalian species, having superficial structural features resembling those of insulin. (wiley.com)
- Our results indicate that relaxin mediates the renal vasodilatory responses to pregnancy and thus may be important for maternal and fetal health. (nih.gov)
- They also raise the likelihood of a role for relaxin in other cardiovascular changes of pregnancy, and they suggest that, like estrogen, relaxin should be considered a regulator of cardiovascular function. (nih.gov)
- Relaxin 1 (also referred to as Relaxin or RLXH1) is a peptide hormone produced by the corpora lutea of the ovary during pregnancy in many mammalian species, including human. (scbt.com)
- Relaxin 2, a related protein, is selectively expressed in the ovary during pregnancy. (scbt.com)
- The Witness Relaxin test kit is intended to determine pregnancy in canine and feline patients, as well as to distinguish between pseudo pregnancy and gestation. (atozvetsupply.com)
- Feline: Pregnancy Detection in the Cat: Serum/plasma relaxin concentrations increase from days 20 to 31 after mating and remain elevated throughout pregnancy and for the first few days after queening. (atozvetsupply.com)
20021
- In 2002, a second form of relaxin, which is found primarily in the brain, was discovered. (wiley.com)
Protein5
- Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw. (wikipedia.org)
- Claims 15 to 17 related to processes for making a DNA transfer vector comprising relaxin DNA, for making a fusion protein comprising relaxin, and for synthesizing H2-relaxin, respectively. (epo.org)
- Each Relaxin R2/LGR8 Peptide and Relaxin R2/LGR8 Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
- In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. (biomedsearch.com)
- Zusätzlich bieten wir Ihnen Relaxin 1 Antikörper (90) und Relaxin 1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
20201
- Cite this: Long-term Muscle Relaxant Use Nearly Triples in the US - Medscape - Jun 30, 2020. (medscape.com)
Genes1
- 8. The Relationship between Relaxin Family Genes in Humans and Teleosts Revealed Through Bioinformatic Analyses and the Expression of Three RLN Genes in Teleosts Verified (Sergey Yegorov et al. (wiley.com)
Effect of relaxin1
- This antifibrotic effect of relaxin did not appear to be mediated by systemic hemodynamic changes since the mean arterial pressure was not significantly different among the groups. (nih.gov)
Effects of relaxin3
- Effects of relaxin on experimentally-induced myocardial infarction. (springer.com)
- Recently, biological effects of relaxin in the heart, kidney, liver, and brain have been identified, and these discoveries have triggered additional interest in possible clinical applications for relaxin. (wiley.com)
- The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix. (biomedsearch.com)
Actions of relaxin2
- The actions of relaxin are highly species specific. (biomedsearch.com)
- The findings suggest autocrine and/or paracrine actions of relaxin on spermatozoa, either before or after ejaculation, which have possible roles on the fertilizing potential of spermatozoa. (unboundmedicine.com)
Function of relaxin1
- The function of relaxin in humans is not clear, although it has several functions in animals. (bionity.com)
Enhances motility of sperm2
- citation needed] In males, relaxin enhances motility of sperm in semen. (wikipedia.org)
- In males, relaxin also has a function: it enhances motility of sperm in semen . (wikipedia.org)
Ligaments1
- citation needed] It also relaxes other pelvic ligaments. (wikipedia.org)
Cervix5
- it also softens the cervix (cervical ripening), and relaxes the uterine musculature. (wikipedia.org)
- In animals relaxin widens the pubic bone and facilitates labor, it also softens the cervix (cervical ripening), and relaxes the uterine musculature. (bionity.com)
- Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. (abcam.com)
- In pigs, rats, and mice, relaxin promotes growth and softening of the cervix, enabling rapid and safe delivery of the fetuses. (wiley.com)
- Relaxin is best known as a hormone of parturition that promotes growth and softening of the cervix, development of the mammary gland, and has a marked impact on the uterus. (rndsystems.com)
Antibodies2
- WITNESS ® RELAXIN is a simple test based on Rapid Immuno Migration (RIM™) technology that uses the combination of two anti-Relaxin antibodies to quickly identify this hormone in biological samples (serum or plasma) from the bitch and queen. (drugs.com)
- Using a gravid rodent model, we employ two approaches to eliminate relaxin or its biological activity from the circulation: ovariectomy and administration of neutralizing antibodies. (nih.gov)
Insl71
- Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity," Organic and Biomolecular Chemistry , vol. 7, no. 8, pp. 1547-1553, 2009. (hindawi.com)
Witness Relaxin4
- This page contains information on Witness Relaxin for veterinary use . (drugs.com)
- The WITNESS ® RELAXIN test provides an early, inexpensive and reliable way to determine success or failure of a planned mating or unwanted exposure. (drugs.com)
- Witness Relaxin Test Kit 5ct. (atozvetsupply.com)
- Canine: The WITNESS Relaxin tests offers an early, inexpensive and reliable means of determining the success or failure of a planned mating or unwanted exposure. (atozvetsupply.com)
Hormone relaxin1
- However, besides steroids, the ovary also produces the peptide hormone relaxin (RLX), which provides potent vasoactive effects which render it the most likely candidate as the elusive physiological shield against CVD in fertile women. (dovepress.com)
RXFP12
- All samples were subjected to immunofluorescence and/or western immunoblotting for relaxin, RXFP1, and RXFP2 detection. (unboundmedicine.com)
- Epididymal and ejaculated spermatozoa were immunopositive to relaxin, RXFP1, and RXFP2, and epididymal corpus-derived spermatozoa had the highest immunoreactivities across epididymal sections. (unboundmedicine.com)
Uterine2
- Relaxin exerts dramatic uterine effects in this model, including a pronounced increase in uterine weight and stimulation of endometrial angiogenesis. (biomedsearch.com)
- By inhibiting uterine contractions, Relaxin 1 may influence the timing of parturition. (scbt.com)
Species4
- Relaxin-3 is a neuropeptide that was discovered in 2001, and which is highly conserved in species ranging from flies, fish, rodents and humans. (wikipedia.org)
- The relaxin-3 peptide is highly expressed in a small region of the brain and in species from teleost to primates and has both conserved sequence and sites of expression. (nih.gov)
- Generally 30-60% sequence homology is observed between relaxin 2 among species. (atlasgeneticsoncology.org)
- In these species relaxin also promotes growth and development of the mammary apparatus. (wiley.com)
Cardiovascular4
- In the cardiovascular system, relaxin works mainly by activating the nitric oxide pathway. (wikipedia.org)
- Relaxin has been shown to relax vascular smooth muscle cells and increase nitric oxide production in rat endothelial cells, thus playing a role in regulation of cardiovascular function by dilating systemic resistance arteries. (wikipedia.org)
- The invention concerns the use of relaxin in the cardiovascular therapy, and specifically in the treatment of acute and chronic heart failure. (google.com)
- More particularly, this invention concerns the use of relaxin in cardiovascular therapy, and specifically in the treatment of heart failure. (google.com)
Estrogen1
- Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. (abcam.com)
Serum7
- The test measures Relaxin levels in plasma and serum samples. (drugs.com)
- In the relaxin-treated BEA rats, serum creatinine was normal, and albumin excretion was slightly decreased. (nih.gov)
- In a population of acute HF patients, admission relaxin (zeige 0 ELISA Kits ) serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin (zeige 0 ELISA Kits ) as a biomarker in this setting. (antikoerper-online.de)
- Although serum relaxin (zeige 0 ELISA Kits ) level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin (zeige 0 ELISA Kits ) has a limited and indefinite role in patients with BJHS. (antikoerper-online.de)
- Serum concentrations of relaxin (zeige 0 ELISA Kits ) showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. (antikoerper-online.de)
- The kit measures relaxin produced by the developing placenta(s) in plasma and serum samples. (atozvetsupply.com)
- A sudden decrease of serum relaxin level may indicate that abortion has occurred. (atozvetsupply.com)
RXFP32
- From these centres, relaxin-3 innervates a broad range of brain regions which are also rich in RXFP3 mRNA/binding sites, including the extended limbic system and the septohippocampal pathway. (wikipedia.org)
- The broad distribution of relaxin-3 fibres/RXFP3 within several key neuronal circuits suggests an ability to modulate a broad range of behaviours. (wikipedia.org)
Serelaxin1
- A recombinant form of human relaxin-2 has been developed as investigational drug RLX030 ( serelaxin ). (wikidoc.org)
Rats2
MRNA1
- In horses alone, the embryo in the uterus will express relaxin mRNA at least 8 days after ovulation. (wikipedia.org)
Fibrosis5
- citation needed] Relaxin has been shown to reduce cardiac fibrosis in animal models by inhibiting cardiac fibroblasts secreting collagen and stimulating matrix metalloproteinase. (wikipedia.org)
- Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. (nih.gov)
- In rodent models of pulmonary and dermal fibrosis, relaxin reduced interstitial fibrosis. (nih.gov)
- By morphometric measurement, relaxin administration was associated with a significant decrease in interstitial fibrosis at the corticomedullary junction. (nih.gov)
- Relaxin may have a useful application in decreasing interstitial fibrosis and thereby slowing the progression of renal disease. (nih.gov)
20011
- Synthesis, conformational studies and biological activity of N α -mono-biotinylated rat relaxin," Journal of Peptide Research , vol. 57, no. 5, pp. 374-382, 2001. (hindawi.com)
Sequence1
- The new millennium bought with it the sequence of the human genome and subsequently new directions for relaxin research. (nih.gov)
Ovarian1
- Prior to ovulation, relaxin will be produced by ovarian stromal cells, which will promote secretion of gelatinases and tissue inhibitors of metalloproteinases. (wikipedia.org)
Skeletal6
- A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone . (wikipedia.org)
- The earliest known use of muscle relaxant drugs was by natives of the Amazon Basin in South America who used poison -tipped arrows that produced death by skeletal muscle paralysis. (wikipedia.org)
- some subcategories of opioids have muscle relaxant properties, and some are marketed in combination drugs with skeletal and/or smooth muscle relaxants such as whole opium products, some ketobemidone , piritramide and fentanyl preparations and Equagesic . (wikipedia.org)
- These images are a random sampling from a Bing search on the term "Skeletal Muscle Relaxant. (fpnotebook.com)
- A synthetic propanediol dicarbamate derivative and an adjunct in the treatment of painful muscle spasms, Carisoprodol is a centrally acting skeletal muscle relaxant that relieves stiffness, pain, and discomfort caused by muscle injuries. (fpnotebook.com)
- A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. (fpnotebook.com)
Matrix metalloproteinases1
- Relaxin may affect collagen metabolism, inhibiting collagen synthesis and enhancing its breakdown by increasing matrix metalloproteinases. (wikipedia.org)
Vascular2
- In the vascular system, nitric oxide relaxes blood vessels and helps regulate blood pressure. (thefreedictionary.com)
- In particular, RLX has a specific relaxant effect on peripheral and coronary vasculature, exerted by the stimulation of endogenous nitric oxide (NO) generation by cells of the vascular wall, and can induce angiogenesis. (dovepress.com)
Synthesis1
- Since its initial isolation from the ovaries of pregnant pigs in 1976, increasing interest in relaxin has led to increased understanding of the chemistry, synthesis, secretion, biological roles, mechanisms of action, and potential clinical applications of relaxin in humans and domestic animals. (wiley.com)
Biological2
- Relaxin can be detected in biological samples soon after implantation of the fertilized egg, which occurs about 18 days after LH surge. (drugs.com)
- Relaxin can be detected in biological samples as early as 20 days after the luteinizing hormone (LH) surge has occurred. (atozvetsupply.com)
Fragment1
- were directed to processes for the production of the fragments according to claims 1 to 7, claims 10, 11 (partly), 12 to 14 were directed to DNA transfer vectors comprising a DNA fragment encoding H2-relaxin. (epo.org)
Ovaries1
- Occasionally, false positive results may occur in non-pregnant queens with elevated Relaxin levels due to cystic ovaries. (drugs.com)
Trophoblast1
- Placental trophoblast cells produce relaxin, however, the size of the placenta does not determine the level of relaxin production. (wikipedia.org)
Endometrium1
- Relaxin may be involved in the vital process of decidualisation, working alongside steroid hormones to allow the endometrium to prepare for implantation. (wikipedia.org)
Family3
- Relaxin family peptide systems and the central nervous system. (nih.gov)
- Relaxin, a hormone of the insulin-growth factor family, promotes collagen remodeling. (nih.gov)
- Here we demonstrate a key role for relaxin, a member of the IGF family that is secreted by the corpus luteum in humans and rodents. (nih.gov)