In eukaryotes, a genetic unit consisting of a noncontiguous group of genes under the control of a single regulator gene. In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Proteins found in any species of bacterium.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
The functional hereditary units of BACTERIA.
Proteins obtained from ESCHERICHIA COLI.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A species of gram-positive bacteria that is a common soil and water saprophyte.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
The in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.
The genetic complement of a BACTERIA as represented in its DNA.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
Inorganic salts of phosphoric acid.
The regulatory elements of an OPERON to which activators or repressors bind thereby effecting the transcription of GENES in the operon.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subunits including sigma factor 54.
A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Proteins that bind to and are involved in the metabolism of phosphate ions.
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.

PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp. (1/1176)

As enteric pathogens, Salmonella spp. are resistant to the actions of bile. Salmonella typhimurium and Salmonella typhi strains were examined to better define the bile resistance phenotype. The MICs of bile for wild-type S. typhimurium and S. typhi were 18 and 12%, respectively, and pretreatment of log-phase S. typhimurium with 15% bile dramatically increased bile resistance. Mutant strains of S. typhimurium and S. typhi lacking the virulence regulator PhoP-PhoQ were killed at significantly lower bile concentrations than wild-type strains, while strains with constitutively active PhoP were able to survive prolonged incubation with bile at concentrations of >60%. PhoP-PhoQ was shown to mediate resistance specifically to the bile components deoxycholate and conjugated forms of chenodeoxycholate, and the protective effect was not generalized to other membrane-active agents. Growth of both S. typhimurium and S. typhi in bile and in deoxycholate resulted in the induction or repression of a number of proteins, many of which appeared identical to PhoP-PhoQ-activated or -repressed products. The PhoP-PhoQ regulon was not induced by bile, nor did any of the 21 PhoP-activated or -repressed genes tested play a role in bile resistance. However, of the PhoP-activated or -repressed genes tested, two (prgC and prgH) were transcriptionally repressed by bile in the medium independent of PhoP-PhoQ. These data suggest that salmonellae can sense and respond to bile to increase resistance and that this response likely includes proteins that are members of the PhoP regulon. These bile- and PhoP-PhoQ-regulated products may play an important role in the survival of Salmonella spp. in the intestine or gallbladder.  (+info)

Induction of the soxRS regulon of Escherichia coli by superoxide. (2/1176)

The soxRS regulon orchestrates a multifaceted defense against oxidative stress, by inducing the transcription of approximately 15 genes. The induction of this regulon by redox agents, known to mediate O-2 production, led to the view that O-2 is one signal to which it responds. However, redox cycling agents deplete cellular reductants while producing O-2, and one may question whether the regulon responds to the depletion of some cytoplasmic reductant or to O-2, or both. We demonstrate that raising [O-2] by mutational deletion of superoxide dismutases and/or by addition of paraquat, both under aerobic conditions, causes induction of a member of the soxRS regulon and that a mutational defect in soxRS eliminates that induction. This establishes that O-2, directly or indirectly, can cause induction of this defensive regulon.  (+info)

Mutational analysis of the phoD promoter in Bacillus subtilis: implications for PhoP binding and promoter activation of Pho regulon promoters. (3/1176)

The PhoP-PhoR two-component regulatory system controls the phosphate deficiency response in B. subtilis. A number of Pho regulon genes which require PhoP approximately P for activation or repression have been identified. The studies reported here were initiated to understand the PhoP-DNA interaction necessary for Pho promoter regulation. The regulatory region of phoD was characterized in detail using oligo-directed mutagenesis, DNase I footprinting, and in vivo transcription assays. These data reveal basic principles of PhoP binding relevant to PhoP's interaction with other Pho regulon promoters. Our results show that: (i) a dimer of PhoP approximately P is able to bind two consensus repeats in a stable fashion; (ii) PhoP binding is highly cooperative within the core promoter region, which is located from -66 to -17 on the coding strand and contains four TT(A/T/C)ACA-like repeats; (iii) specific bases comprising the TT(A/T/C)ACA consensus are essential for transcriptional activation, but the specific base pairs of the intervening sequences separating the consensus repeats are not important for either PhoP binding or promoter activation; (iv) the spacing between two consensus repeats within a putative dimer binding site in the core region is important for both PhoP binding and promoter activation; (v) the exact spacing between two dimer binding sites within the core region is important for promoter activation but less so for PhoP binding affinity, as long as the repeats are on the same face of the helix; and (vi) the 5' secondary binding region is important for coordinated PhoP binding to the core binding region, making it nearly essential for promoter activation.  (+info)

Nitroreductase A is regulated as a member of the soxRS regulon of Escherichia coli. (4/1176)

Nitroreductase A catalyzes the divalent reduction of nitro compounds, quinones, and dyes by NADPH. In this paper, nitroreductase A is induced in Escherichia coli by exposure to paraquat in a manner that depends on the expression of soxR. Nitroreductase activity was only slightly induced by paraquat in a strain bearing a mutational defect in the gene encoding nitroreductase A, but it was approximately 3-fold induced in the parental strain. Nitroreductase A thus appears to be a member of the soxRS regulon and probably contributes to the defenses against oxidative stress by minimizing the redox cycling attendant upon the univalent reduction of nitro compounds, quinones, and dyes.  (+info)

Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli. (5/1176)

The pseudooligosaccharide acarbose is a potent inhibitor of amylases, glucosidases, and cyclodextrin glycosyltransferase and is clinically used for the treatment of so-called type II or insulin-independent diabetes. The compound consists of an unsaturated aminocyclitol, a deoxyhexose, and a maltose. The unsaturated aminocyclitol moiety (also called valienamine) is primarily responsible for the inhibition of glucosidases. Due to its structural similarity to maltotetraose, we have investigated whether acarbose is recognized as a substrate by the maltose/maltodextrin system of Escherichia coli. Acarbose at millimolar concentrations specifically affected the growth of E. coli K-12 on maltose as the sole source of carbon and energy. Uptake of radiolabeled maltose was competitively inhibited by acarbose, with a Ki of 1.1 microM. Maltose-grown cells transported radiolabeled acarbose, indicating that the compound is recognized as a substrate. Studying the interaction of acarbose with purified maltoporin in black lipid membranes revealed that the kinetics of acarbose binding to LamB is asymmetric. The on-rate of acarbose is approximately 30 times lower when the molecule enters the pore from the extracellular side than when it enters from the periplasmic side. Acarbose could not be utilized as a carbon source since the compound alone was not a substrate of amylomaltase (MalQ) and was only poorly attacked by maltodextrin glucosidase (MalZ).  (+info)

In vivo transcription of the Escherichia coli oxyR regulon as a function of growth phase and in response to oxidative stress. (6/1176)

Simultaneous expression of seven genes in Escherichia coli was measured by a reverse transcription-multiplex PCR fluorescence procedure. Genes studied were (i) oxyR (transcriptional regulator); (ii) katG, dps, gorA, and ahpCF (controlled by OxyR); (iii) sodA (controlled by SoxRS); and (iv) trxA (not related to OxyR or SoxRS). Except for trxA, transcription of all genes was activated during the course of growth of wild-type bacteria, though notable variations were observed with respect to both the time and extent of activation. Whereas oxyR, katG, dps, and gorA were activated during exponential growth, ahpCF and sodA were stimulated in stationary phase. Maximal induction ranged from 4.6- to 86.5-fold, for gorA and dps, respectively. Treatment with H2O2 stimulated expression of the genes (katG, dps, ahpCF, and gorA) previously identified as members of the OxyR regulon, except for oxyR itself. Induction by H2O2 was a remarkably rapid and reversible process that took place in an OxyR-dependent and sigmaS-independent manner. NaCl induced expression of the genes controlled by OxyR, including the oxyR locus. This transcriptional up-regulation was preserved in a strain with the DeltaoxyR::kan mutation, but it was abolished (ahpCF) or significantly reduced (oxyR and dps) in a strain with the rpoS::Tn10 mutation, potentially reflecting positive transcriptional regulation of the oxyR regulon by sigmaS. Expression of trxA was not increased either by H2O2 stress or by a shift to high-osmolarity conditions.  (+info)

Identification and transcriptional analysis of new members of the sigmaB regulon in Bacillus subtilis. (7/1176)

Bacillus subtilis responds to various stimuli (heat, ethanol and salt stress, energy starvation) with the induction of general stress proteins (GSPs). Most of them belong to the stress and stationary-phase regulon controlled by the alternative sigma factor sigmaB. The majority of sigmaB-dependent proteins are thought to provide a precautionary general stress resistance in stressed or starved cells. In this report, the identification and transcriptional analysis of nine new members of the sigmaB regulon are described. The biochemical function was not determined for any of the proteins encoded by the nine new sigmaB-dependent stress genes, however, similarities to proteins in the databases allowed a distinction between proteins with putative (i-iv) and unknown (v) function. The putative functions of BmrU, YcdF, YdaD, YdaP, YhdN and YocK underline the suggested protective role of sigmaB-dependent GSPs and also elucidate new areas where sigmaB might play an important role. (i) The finding that the bmrUR operon is under sigmaB control indicates that the elimination of multidrug compounds might be a new function in multiple stress resistance. (ii) YcdF and YdaD resemble NAD(P)-dependent dehydrogenases. Both proteins could be involved in the generation of NAD(P)H and therefore in the maintenance of the intracellular redox balance under stress. (iii) The ydaP gene might belong to the increasing number of sigmaB-dependent genes whose orthologues are under the control of sigmas in Escherichia coli, indicating that both regulons may fulfil similar functions. (iv) YhdN shows weak similarities to potassium ion channel proteins and YocK shows resemblance to the DnaK suppressor protein DksA. (v) Three new sigmaB-dependent genes (ydaE, ydaG and yfkM) encoding proteins with still unknown functions were also described. Further analyses of corresponding mutants might allow a first prediction of their function within the framework of the general stress regulon.  (+info)

A HilA-independent pathway to Salmonella typhimurium invasion gene transcription. (8/1176)

Salmonella typhimurium invasion of nonphagocytic cells requires the expression of a type III secretion system (TTSS) encoded within Salmonella pathogenicity island 1 (SPI1). TTSS gene transcription is activated in response to environmental signals and requires transcriptional regulators encoded within (HilA) and outside (SirA) SPI1. Two unique loci, sirB and sirC, which contribute to SPI1 gene transcription were defined. sirC is an SPI1-encoded transcription factor of the AraC family that contributes to the invasive phenotype. sirB is required for maximal expression of sirC and consists of two open reading frames located near kdsA, a gene involved in lipopolysaccharide biosynthesis. sirC expression, unlike expression of other SPI1 genes, does not require HilA. Overexpression of sirC or sirA restores expression of a subset of SPI1 genes, including invF and sspC, in the absence of HilA. These data define roles for SirC and SirA as part of a HilA-independent pathway to SPI1 gene expression. We postulate that HilA-independent activation of inv expression is important for efficient assembly and function of the SPI1 TTSS.  (+info)

Regulons can sometimes be pathogenicity islands. The Ada regulon in E. coli is a well-characterized example of a group of genes ... Commonly studied regulons in bacteria are those involved in response to stress such as heat shock. The heat shock response in E ... Regulon at the US National Library of Medicine Medical Subject Headings (MeSH) (CS1 errors: generic name, Articles with GND ... In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory ...
In bacterial genetics, the mal regulon is a regulon - or group of genes under common regulation - associated with the ... "Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae". PLOS ONE. 10 (6): ...
The Nif regulon is a set of seven operons used to regulate nitrogen fixation in the coliform bacterium Klebsiella pneumoniae ... The Nif regulon is regulated in response to a variety of environmental signals to ensure nitrogen-fixation only occurs when ... The nif regulon comprises 7 operons: nifRLA, nifJ, nifHDK, nifEN, nifUSVM, nifWF, nifBQ. nifRLA operon: The tight expression ...
The Ada protein activates the transcription of the Ada regulon in two different ways. In case of the ada-alkB operon, and the ... In DNA repair, the Ada regulon is a set of genes whose expression is essential to adaptive response (also known as "Ada ...
A Reassessment of the FNR Regulon and Transcriptomic Analysis of the Effects of Nitrate, Nitrite, NarXL, and NarQP as ...
Although the Pho regulon system is most widely studied in Escherichia coli it is found in other bacterial species such as ... The Pho regulon is controlled by a two-component regulatory system composed of a histidine kinase sensor protein (PhoR) within ... The gene responsible for this protein is PhoB-dependent, and can only be turned on when the Pho regulon is activated by low Pi ... The Phosphate (Pho) regulon is a regulatory mechanism used for the conservation and management of inorganic phosphate within ...
Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245-51. doi:10.1111/j.1365- ...
lac operon Weickert, M. J.; Adhya, S. (October 1993). "The galactose regulon of Escherichia coli". Molecular Microbiology. 10 ( ...
GalR is a transcriptional regulator of the galactose regulon composed of genes encoding enzymes for transport and metabolism of ... Weickert MJ, Adhya S (October 1993). "The galactose regulon of Escherichia coli". Molecular Microbiology. 10 (2): 245-51. doi: ...
Brown, S.; Cole, M. & Erives, A.J. (2008). "Evolution of the holozoan ribosome biogenesis regulon". BMC Genomics. 9: 442. doi: ...
The first is through the FNR regulon. The FNR controlled regulation of nikABCDE-nikR occurs at a FNR box located upstream of ...
Nif regulon (Klebsiella pneumoniae) Spaink, Herman P (1998). The Rhizobiaceae: Molecular Biology of Model Plant-Associated ...
SoxRS regulon genes can be regulated by additional factors. At least three known genes including xthA and katE are regulated by ... Regulation of the soxRS regulon occurs by a two-stage process: the SoxR protein is first converted to an oxidized form that ... The oxidized form of this factor specifically binds to the promoters of constituent genes of OxyR regulon, including katG ( ... The transcriptional factor OxyR regulates the expression of OxyR regulon. H2O2 oxidizes the transcriptional factor by forming ...
Bhat PJ (2 March 2008). Galactose Regulon of Yeast: From Genetics to Systems Biology. Springer Science & Business Media. ISBN ...
"A miR-19 regulon that controls NF-iB signaling". Nucleic Acids Research. 40 (16): 8048-8058. doi:10.1093/nar/gks521. PMC ...
Keene, J. D. (January 2007). "Biological Clocks and the Coordination Theory of RNA Operons and Regulons". Cold Spring Harbor ... He formalized the posttranscriptional operon and regulon (PTRO) model to describe global gene regulation, and proposed the RNA ... By 2007, Keene proposed the RNA regulon hypothesis, "that mRNAs encoded by functionally related genes may be coordinately ... Simone, Laura E; Keene, Jack D (February 2013). "Mechanisms coordinating ELAV/Hu mRNA regulons". Current Opinion in Genetics & ...
Cozzarelli, Nicholas Robert (1996). The L-L-Glycerophosphate Regulon in Escherichia coli (PhD thesis). Harvard University. OCLC ...
Hondorp ER, McIver KS (December 2007). "The Mga virulence regulon: infection where the grass is greener". Molecular ... the missing links between the CovR regulatory cascade and the Mga regulon". Molecular Microbiology. 66 (6): 1506-22. doi: ...
"Genome-wide analysis of the RpoN regulon in Geobacter sulfurreducens". BMC Genomics. 10: 331. doi:10.1186/1471-2164-10-331. PMC ...
Pelechano, V; Jimeno-González, S; Rodríguez-Gil, A; García-Martínez, J; Pérez-Ortín, JE; Chávez, S (Aug 2009). "Regulon- ...
Coornaert A, Lu A, Mandin P, Springer M, Gottesman S, Guillier M (April 2010). "MicA sRNA links the PhoP regulon to cell ... "Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins". Journal ...
Keene JD (2007). "RNA regulons: coordination of post-transcriptional events". Nature Reviews Genetics. 8 (7): 533-543. doi: ...
She presented a paper entitled The Xanthomonas axonopodis citri PHO regulon. Most media relating to Taschner can be found on ...
This single [repressor controls the transcription of the whole fad regulon. Binding of fadR is specifically inhibited by long ...
Rao, N. N., Wang, E., Yashphe, J., & Torriani, A. (1986). Nucleotide pool in pho regulon mutants and alkaline phosphatase ... Torriani, Annamaria (August 1990). "From cell membrane to nucleotides: The phosphate regulon in Escherichia coli". BioEssays. ...
P. Chen, D. I. Andersson & J. R. Roth (September 1994). "The control region of the pdu/cob regulon in Salmonella typhimurium". ... control the cobalamin/propanediol regulon of Salmonella typhimurium". Journal of Bacteriology. 175 (22): 7200-7208. doi:10.1128 ...
Bacterial small RNA Shimizu, T; Yaguchi, H; Ohtani, K; Banu, S; Hayashi, H (Jan 2002). "Clostridial VirR/VirS regulon involves ... Shimizu, T; Yaguchi, H; Ohtani, K; Banu, S; Hayashi, H (Jan 2002). "Clostridial VirR/VirS regulon involves a regulatory RNA ... "Identification of a two-component VirR/VirS regulon in Clostridium perfringens". Anaerobe. 16 (3): 258-264. doi:10.1016/j. ... "Identification of a two-component VirR/VirS regulon in Clostridium perfringens". Anaerobe. 16 (3): 258-264. doi:10.1016/j. ...
... s are related to regulons, stimulons and modulons; whereas operons contain a set of genes regulated by the same operator ... regulons contain a set of genes under regulation by a single regulatory protein, and stimulons contain a set of genes under ...
Silakowski, B.; Kunze, B.; Nordsiek, G.; Blöcker, H.; Höfle, G.; Müller, R. (2000). "The myxochelin iron transport regulon of ...
Png, K. J.; Halberg, N.; Yoshida, M.; Tavazoie, S. F. (2011). "A microRNA regulon that mediates endothelial recruitment and ...
A Post-transcriptional Regulon Controlled by TtpA, the Single Tristetraprolin Family Member Expressed in Dictyostelium ... A Post-transcriptional Regulon Controlled by TtpA, the Single Tristetraprolin Family Member Expressed in Dictyostelium ... Synopsis A Post-transcriptional Regulon Controlled by TtpA, the Single Tristetraprolin Family Member Expressed in Dictyostelium ... Discoideum [Abstract A Post-transcriptional Regulon Controlled by TtpA, the Single Tristetraprolin Family Member Expressed in ...
A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium ... A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium ... In Dictyostelium, TtpA may control an RNA regulon, where a single RNA binding protein, TtpA, post-transcriptionally co- ...
van Schaik W, van der Voort M, Molenaar D, Moezelaar R, de Vos WM, Abee T. Identification of the sigma(B) regulon of Bacillus ... van Schaik, W, van der Voort, M, Molenaar, D, Moezelaar, R, de Vos, WM & Abee, T 2007, Identification of the sigma(B) regulon ... Identification of the sigma(B) regulon of Bacillus cereus and conservation of sigma(B)-regulated genes in low-GC-content gram- ... Identification of the sigma(B) regulon of Bacillus cereus and conservation of sigma(B)-regulated genes in low-GC-content gram- ...
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Regulon Substances * Antigens, Bacterial Grant support * N01AI15447/AI/NIAID NIH HHS/United States ...
The BvgAS Regulon of Bordetella pertussis.. Moon K, Bonocora RP, Kim DD, Chen Q, Wade JT, Stibitz S, Hinton DM.. mBio (2017 Oct ...
Does C. psittacihave a regulon controlled by trpR?. In E. coli the trp repressor binds upstream of the trp operon and upstream ... might comprise a regulon controlled by the trpR repressor. Indeed, CTAG and/or CTCG motifs were found upstream of all these ...
Overall, comparison of the global transcriptome in response to CSP shows the conservation of the ComE and SigX-core regulons in ... The ComE regulon presented a modestly higher upregulation when exposed to TSB, whereas the SigX regulon seemed to respond ... Core genes SigX regulon of the mitis group. Synteny conservation of S. mitis type strain and SK321, S. pneumoniae, ... Early response: Conservation of the ComE regulon. Genes upregulated by CSP in the S. mitis type strain and SK321 are listed ...
motB overexpression dysregulates hundreds of host genes; ∼70% are within the hns regulon. In infected cells overexpressing motB ... including derepression of much of the hns regulon. ...
Abstract: The tbu regulon of Ralstonia pickettii PKO1 encodes enzymes involved in the catabolism of toluene, benzene, and ... The first operon in this regulon contains genes that encode the tbu pathways initial catabolic enzyme, toluene-3-monooxygenase ... as well as TbuT, the NtrC-like transcriptional activator for the entire regulon. It has been previously shown that the ... Regulon/genetics; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Toluene/metabolism*; ...
Distinct molecular mechanisms involved in carbon catabolite repression of the arabinose regulon in Bacillus subtilis José ... Glucose exerts an additional repression of the ara regulon, which requires a functional araR. ... that CcpA most probably complexed with HPr-Ser46-P plays the major role in carbon catabolite repression of the ara regulon by ...
"Signal transduction in the purin regulon". FALL 1993. Michael Rosenfield, Howard Hughes Medical Institute, University of ...
Figure 2: Expression of the soxS gene (SoxRS regulon) in E. coli TN530 (a) and the sA gene (SOS regulon) in E. coli PQ37 (b), ... and the sA gene (SOS regulon) in E. coli PQ37 (3,4), induced by 0.1 mM NO- ... SOS regulon in E. coli strain PQ37 by S-nitrosothiols (GSNO, SNAP) and ... Activation of the Escherichia coli SoxRS-regulon by nitric oxide and its ...
9. The eIF4E RNA regulon promotes the Akt signaling pathway.. Culjkovic B; Tan K; Orolicki S; Amri A; Meloche S; Borden KL. J ... 2. eIF4E is a central node of an RNA regulon that governs cellular proliferation.. Culjkovic B; Topisirovic I; Skrabanek L; ... 1. Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E.. Culjkovic ...
Kimuda, S. G. et al. Humoral responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins of mycobacterium ... Doddam, S. N., Peddireddy, V. & Ahmed, N. Mycobacterium tuberculosis DosR regulon gene Rv2004c encodes a novel antigen with pro ... The peptide library represented 52 dormancy-associated M. tb proteins, consisting of 47 entries regulated by DosR regulon, two ... The group of dormancy-associated proteins include DosR regulon-encoded proteins, universal stress proteins, starvation stimulon ...
Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol. ...
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. Mol. Cell 68, 1-14. doi:10.1016/j.molcel.2017.09.003. ...
The SOS system is a regulon; that is, it controls expression of several genes distributed throughout the genome simultaneously ...
Regulon Preferred Term Term UI T054114. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Regulon Preferred Concept UI. M0027279. Scope Note. In eukaryotes, a genetic unit consisting of a noncontiguous group of genes ... In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of ... In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of ...
Biological Clocks and the Coordination Theory of RNA Operons and Regulons. J.D. Keene. Role of Phosphorylation in the Mammalian ...
Expanding the manganese regulon in Escherichia coli: a new small protein, mntS and efflux pump, mntP. Tuesday, October 25, 2011 ...
Interestingly, most of the upregulated genes are in the Fe regulon that gets activated by the first responder Atf1p. ...
The FldA and FldB from Escherichia coli are both members of the SoxRS regulon, an adaptive system responsive to oxidative ...
complete regulon hypothalamic network in GraphML extendable; 7) metadata process explaining all experimental, computational ...
... and a chromosomal regulon (PhoP/Q), which allows bacterial survival in macrophages. ...
Waters, L. S., Sandoval, M. and Storz, G. (2011) The Escherichia coli MntR mini regulon includes genes encoding a small protein ...
  • Overall, comparison of the global transcriptome in response to CSP shows the conservation of the ComE and SigX-core regulons in competent S. mitis isolates, as well as species and strain-specific genes. (biomedcentral.com)
  • The first operon in this regulon contains genes that encode the tbu pathway's initial catabolic enzyme, toluene-3-monooxygenase, as well as TbuT, the NtrC-like transcriptional activator for the entire regulon. (nih.gov)
  • Their experiments led them to the so-called dormancy regulon, a group of genes that creates the proteins responsible for initiating and maintaining the dormant state. (newsfood.com)
  • Probably the intact PhoP suppresses the genes of the dormancy regulon and so causes the bacteria to wake up,' speculates the professor. (newsfood.com)
  • Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
  • There are multiple sigma factors in E. coli, and each holoenzyme specifically recognizes a set of genes (a regulon). (nih.gov)
  • In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS . (nih.gov)
  • We previously discovered that the SoxRS regulon of E. coli is activated in response to elevated dissolved oxygen concentration mainly to protect the bacteria from possible oxygen damage. (nih.gov)
  • Expanding the direct HetR regulon in Anabaena sp. (bvsalud.org)
  • Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders. (cdc.gov)
  • Whole-Genome Expression Profiling Defines the HrpL Regulon of Pseudomonas syringae pv. (btiscience.org)
  • Whether 8- and 10-fold relative increases in the adherence of hha and sdiA hha mutants, respectively, resulted from differential increases in fimbrial, flagellar, and LEE regulon expression remains to be determined. (usda.gov)
  • We hypothesized that the 16-fold increase in the expression of this regulon make it possible candidate for inducing the expression of recombinant proteins. (nih.gov)
  • Regulation of the multiple antibiotic resistance (mar) regulon by marORA sequences in Escherichia coli. (nih.gov)
  • By microscopic analysis of fluorescent-labeled GalR, a regulon-specific transcription factor in Escherichia coli, we observed that GalR is present in the cell as aggregates (one to three fluorescent foci per cell) in nongrowing cells. (nih.gov)
  • [ 29 ] Physiological analyses of a M. tuberculosis dosR- knockout strain demonstrated that the massive loss of viability correlates with a collapse of energy and redox homeostasis, thus suggesting that the DosR regulon encodes critical functions required for adaptation to the reduced metabolic state, which is characteristic of nonreplicating tubercle bacilli. (medscape.com)
  • The tbu regulon of Ralstonia pickettii PKO1 encodes enzymes involved in the catabolism of toluene, benzene, and related alkylaromatic hydrocarbons. (nih.gov)
  • 1. Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. (nih.gov)