The flow of BLOOD through or around an organ or region of the body.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The circulation of blood through the CORONARY VESSELS of the HEART.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
Scandium. An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45.
The circulation of the BLOOD through the vessels of the KIDNEY.
The circulation of BLOOD through the LIVER.
The circulation of the BLOOD through the LUNGS.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Measurement of oxygen and carbon dioxide in the blood.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
The placing of a body or a part thereof into a liquid.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Drugs used to cause dilation of the blood vessels.
The posture of an individual lying face up.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Elements of limited time intervals, contributing to particular results or situations.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The hollow, muscular organ that maintains the circulation of the blood.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
The inferior part of the lower extremity between the KNEE and the ANKLE.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Part of the arm in humans and primates extending from the ELBOW to the WRIST.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Injections made into a vein for therapeutic or experimental purposes.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The veins and arteries of the HEART.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The vessels carrying blood away from the heart.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Contractile activity of the MYOCARDIUM.
The minute vessels that connect the arterioles and venules.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
Relatively complete absence of oxygen in one or more tissues.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.
The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.
Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
Recording of change in the size of a part as modified by the circulation in it.
The position or attitude of the body.
The arterial blood vessels supplying the CEREBRUM.
Substances used to allow enhanced visualization of tissues.
A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The blood vessels which supply and drain the RETINA.
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Treatment process involving the injection of fluid into an organ or tissue.
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
The TEMPERATURE at the outer surface of the body.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The main artery of the thigh, a continuation of the external iliac artery.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

Intrarenal site of action of calcium on renin secretion in dogs. (1/9283)

We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release. Both calcium chloride and calcium gluconate reduced renal blood flow and renin secretion while renal perfusion pressure was unchanged. These data indicate that calcium inhibition of renin secretion did not occur primarily at the renal vascular receptor; decreased renal blood flow is usually associated with increased renin secretion. Calcium chloride infusion increased urinary chloride excretion without affecting sodium excretion, and calcium gluconate failed to increase either sodium or chloride excretion. Also, the filtered loads of sodium and chloride were unchanged during the calcium infusions. These results give no indication that calcium inhibited renin secretion by increasing the sodium or chloride load at the macula densa. The effects of intrarenal calcium infusion on renin release were also assessed in dogs with a nonfiltering kidney in which renal tubular mechanisms could not influence renin secretion. The observation that calcium still suppressed renin release in these dogs provides additional evidence that the the major effect of calcium involved nontubular mechanisms. Thus, it appears likely that calcium acted directly on the juxtaglomerular cells to inhibit renin secretion.  (+info)

Vascular remodeling in response to altered blood flow is mediated by fibroblast growth factor-2. (2/9283)

Vascular structures adapt to changes in blood flow by adjusting their diameter accordingly. The factors mediating this process are only beginning to be identified. We have recently established a mouse model of arterial remodeling in which flow in the common carotid artery is interrupted by ligation of the vessel near the carotid bifurcation, resulting in a dramatic reduction in vessel diameter as a consequence of inward remodeling and intimal lesion formation. In the present study, we used this model to determine the role of fibroblast growth factor-2 (FGF-2) in the remodeling response by maintaining neutralizing serum levels of a mouse monoclonal antibody against FGF-2 for 4 weeks. Morphometric analysis revealed that intimal lesion formation was not affected by the antibody. However, lumen narrowing was significantly inhibited, resulting in a greater than 3-fold increase in lumen area in anti-FGF-2-treated animals compared with controls. Treatment with anti-FGF-2 antibody significantly inhibited the reduction in vessel diameter (inward remodeling) and shortening of the internal elastic lamina in the ligated vessel. In addition, anti-FGF-2 treatment also caused outward remodeling of the contralateral carotid artery. These findings identify FGF-2 as an important factor in vascular remodeling, and its effects are likely to be mediated by increasing vascular tone. The results are consistent with the recent observation of reduced vascular tone in the FGF-2-deficient mouse.  (+info)

Role of endothelin in the increased vascular tone of patients with essential hypertension. (3/9283)

We investigated the possible role of endothelin in the increased vasoconstrictor tone of hypertensive patients using antagonists of endothelin receptors. Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intraarterial infusion of blockers of endothelin-A (ETA) (BQ-123) and endothelin-B (ETB) (BQ-788) receptors, separately and in combination, were measured in hypertensive patients and normotensive control subjects. In healthy subjects, BQ-123 alone or in combination with BQ-788 did not significantly modify FBF (P=0.78 and P=0.63, respectively). In hypertensive patients, in contrast, BQ-123 increased FBF by 33+/-7% (P<0.001 versus baseline), and the combination of BQ-123 and BQ-788 resulted in a greater vasodilator response (63+/-12%; P=0.006 versus BQ-123 alone in the same subjects). BQ-788 produced a divergent vasoactive effect in the two groups, with a decrease of FBF (17+/-5%; P=0.004 versus baseline) in control subjects and transient vasodilation (15+/-7% after 20 minutes) in hypertensive patients (P<0.001, hypertensives versus controls). The vasoconstrictor response to endothelin-1 was slightly higher (P=0.04) in hypertensive patients (46+/-4%) than in control subjects (32+/-4%). Our data indicate that patients with essential hypertension have increased vascular endothelin activity, which may be of pathophysiological relevance to their increased vascular tone. In these patients, nonselective ETA and ETB blockade seems to produce a greater vasodilator effect than selective ETA blockade.  (+info)

Bronchial artery perfusion scintigraphy to assess bronchial artery blood flow after lung transplantation. (4/9283)

The bronchial arterial system is inevitably interrupted in transplanted lungs when removing the organs from the donor, but it can be reestablished by direct bronchial artery revascularization (BAR) during implantation. The purpose of this study was to visualize and quantify the distribution of bronchial artery perfusion after en bloc double lung transplantation with BAR, by injecting radiolabeled macroaggregated albumin directly into the bronchial artery system. METHODS: BAR was performed using the internal mammary artery as conduit. Patients were imaged 1 mo (n = 13) or 2 y (n = 9) after en bloc double lung transplantation with BAR. Immediately after bronchial arteriography, 100 MBq macroaggregated albumin (45,000 particles) were injected through the arteriographic catheter. Gamma camera studies were then acquired in the anterior position. At the end of imaging, with the patient remaining in exactly the same position, 81mKr-ventilation scintigraphy or conventional intravenous pulmonary perfusion scintigraphy or both were performed. Images were evaluated by visual analysis, and a semiquantitative assessment of the bronchial arterial supply to the peripheral parts of the lungs was obtained with conventional pulmonary scintigraphy. RESULTS: The bronchial artery scintigraphic images showed that the major part of the bronchial arterial flow supplied central thoracic structures, but bronchial artery perfusion could also be demonstrated in the peripheral parts of the lungs when compared with conventional pulmonary scintigraphy. There were no differences between scintigrams obtained from patients studied 1 mo and 2 y post-transplantation. CONCLUSION: Total distribution of bronchial artery supply to the human lung has been visualized in lung transplant patients. This study demonstrates that this nutritive flow reaches even the most peripheral parts of the lungs and is present 1 mo as well as 2 y after lung transplantation. The results suggest that bronchial artery revascularization may be of significance for the long-term status of the lung transplant.  (+info)

Pulsed Doppler ultrasonographic evaluation of portal blood flow in dogs with experimental portal vein branch ligation. (5/9283)

Portal blood flow was measured using pulsed Doppler ultrasound in 6 dogs before and after left portal vein branch ligation. Mean portal vein blood flow velocity and mean portal vein blood flow were significantly reduced after ligation and the congestion index was increased (p < 0.01). Pulsed Doppler ultrasound studies provide valuable physiological information which may assist the clinician with the diagnosis of canine hepatic circulatory disorders.  (+info)

Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. (6/9283)

Diabetes is a major risk factor for coronary and peripheral artery diseases. Although diabetic patients often present with advanced forms of these diseases, it is not known whether the compensatory mechanisms to vascular ischemia are affected in this condition. Accordingly, we sought to determine whether diabetes could: 1) impair the development of new collateral vessel formation in response to tissue ischemia and 2) inhibit cytokine-induced therapeutic neovascularization. Hindlimb ischemia was created by femoral artery ligation in nonobese diabetic mice (NOD mice, n = 20) and in control C57 mice (n = 20). Hindlimb perfusion was evaluated by serial laser Doppler studies after the surgery. In NOD mice, measurement of the Doppler flow ratio between the ischemic and the normal limb indicated that restoration of perfusion in the ischemic hindlimb was significantly impaired. At day 14 after surgery, Doppler flow ratio in the NOD mice was 0.49+/-0.04 versus 0.73+/-0.06 for the C57 mice (P< or =0.005). This impairment in blood flow recovery persisted throughout the duration of the study with Doppler flow ratio values at day 35 of 0.50+/-0.05 versus 0.90+/-0.07 in the NOD and C57 mice, respectively (P< or =0.001). CD31 immunostaining confirmed the laser Doppler data by showing a significant reduction in capillary density in the NOD mice at 35 days after surgery (302+/-4 capillaries/mm2 versus 782+/-78 in C57 mice (P< or =0.005). The reduction in neovascularization in the NOD mice was the result of a lower level of vascular endothelial growth factor (VEGF) in the ischemic tissues, as assessed by Northern blot, Western blot and immunohistochemistry. The central role of VEGF was confirmed by showing that normal levels of neovascularization (compared with C57) could be achieved in NOD mice that had been supplemented for this growth factor via intramuscular injection of an adenoviral vector encoding for VEGF. We conclude that 1) diabetes impairs endogenous neovascularization of ischemic tissues; 2) the impairment in new blood vessel formation results from reduced expression of VEGF; and 3) cytokine supplementation achieved by intramuscular adeno-VEGF gene transfer restores neovascularization in a mouse model of diabetes.  (+info)

Sonographic evidence for the involvement of the utero-ovarian counter-current system in the ovarian control of directed uterine sperm transport. (7/9283)

Sperm transport from the cervix into the tube is an important uterine function within the process of reproduction. This function is exerted by uterine peristalsis and is controlled by the dominant ovarian structure via a cascade of endocrine events. The uterine peristaltic activity involves only the stratum subvasculare of the myometrium, which exhibits a predominantly circular arrangement of muscular fibres that separate at the fundal level into the fibres of the cornua and continue into the circular muscles of the respective tubes. Since spermatozoa are transported preferentially into the tube ipsilateral to the dominant follicle, this asymmetric uterine function may be controlled by the ovary via direct effects utilizing the utero-ovarian counter-current system, in addition to the systemic circulation. To test this possibility the sonographic characteristics of the uterine vascular bed were studied during different phases of the menstrual cycle. Vaginal sonography with the measurement of Doppler flow characteristics of both uterine arteries and of the arterial anastomoses of the uterine and ovarian arteries (junctional vessels) in the cornual region of both sides of the uterus during the menstrual phase of regular-cycling women demonstrated significant lower resistance indices of the junctional vessels ipsilateral to the side of the dominant ovarian structure as compared with the corresponding arteries contralaterally. By the use of the perfusion mode technique, it could be observed that vascular perfusion of the fundal myometrium was significantly increased ipsilateral to the dominant follicle during the late follicular phase of the cycle. These results show that the endocrine control of the dominant ovarian structure over uterine function is not only exerted via the systemic circulation but also directly, most probably utilizing the utero-ovarian counter-current system.  (+info)

Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. (8/9283)

BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction.  (+info)

Blood flow rate and total blood flow related to length density and total length of blood vessels in mini-pig urinary bladder after chronic outflow obstruction a
Objective: This review aims at evaluating studies investigating the effects of anaesthesia on skeletal muscle blood flow and associated cardiovascular function in anaesthetized horses and discusses how the results of these studies contribute to our understanding of the pathogenesis and prevention of post-anaesthetic myopathy. Database used: Pubmed & personal files. Conclusion: There is little published information on the effects of anaesthesia on skeletal muscle blood flow in horses. Available reports predominantly refer to halothane and isoflurane. The effects of vasoactive drugs have mainly been studied in halothane-anaesthetized horses. The results of these studies support the importance of cardiac output in the maintenance of adequate arterial blood pressure, perfusion pressure and muscle blood flow. Adequate perfusion pressure appears to be important for overcoming the detrimental effects of high intra-compartmental pressure in dependent muscles and hydrostatic pressure in nondependent ...
Neither of the catecholamines affected blood flow distribution unfavorably. Although both catecholamines increased coronary blood flow, this increase can never account for the increase in systemic blood flow, because coronary blood flow expressed as a percentage of systemic blood flow (about 8% in the lambs with shunt) did not change. Because isoproterenol did not change cerebral, renal or splanchnic blood flow, blood flow to the carcass will have been increased. In the lambs with shunt there was no need for an increase in blood flow, because blood flow to the vital organs at rest (except for the heart) was the same in the lambs with shunt and in the control lambs. It remains unclear how isoproterenol affects blood flow distribution when blood flow to the vital organs is jeopardized. Unfortunately, the lambs with shunt in whom that happened died before a proper study could be done. Despite the fact that systemic blood flow was the same in the lambs with shunt and the control lambs, we think our ...
TY - JOUR. T1 - Rapid-onset vasodilator responses to exercise in humans. T2 - Effect of increased baseline blood flow. AU - Dillon, Gabrielle A.. AU - Shepherd, John R.A.. AU - Casey, Darren P.. AU - Dinenno, Frank A.. AU - Curry, Timothy B.. AU - Joyner, Michael J.. AU - Ranadive, Sushant M.. PY - 2020/1/1. Y1 - 2020/1/1. N2 - New Findings: What is the central question of this study? What is the effect of an elevated baseline blood flow, induced by high-dose intra-arterial infusion of either adenosine or ATP, on the rapid-onset vasodilatory response to a single forearm muscle contraction? What is the main finding and its importance? The peak response to a single contraction is unaffected by augmented baseline blood flow, and thus, is likely to be attributable to a feedforward vasodilatory mechanism. Abstract: The hyperaemic responses to single muscle contractions are proportional to exercise intensity, which, in turn, is proportional to tissue metabolic demand. Hence, we tested the hypothesis ...
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This chapter provides an overview of methods for the measurement of hepatic blood flow for the whole liver and hepatic blood perfusion per unit volume of liver tissue. Measurement of the total flow rate is performed by intravenous infusion of a test substance that is eliminated only by the liver, measurements of steady-state arterial and liver venous concentration differences across the organ and calculation by Ficks principle. Indocyanine green (ICG) has been validated as a suitable test substance for such measurements in studies using pigs and is widely used in human studies. Steady-state clearance measurements can be used to measure the total hepatic flow rate for substances with a liver vein concentration that is negligible when compared to the arterial concentration. Sorbitol has been validated as a suitable test substance in healthy subjects (with corrections for urinary excretion) for such measurements. Currently, no other clearance methods have proven suitable. Hepatic blood perfusion ...
Effects of repeated H-Wave device stimulation (HWDS) on blood flow and angiogenesis in the rat hind limb were studied. The hypothesis tested was that HWDS acutely increases hind limb blood flow, and that repeated HWDS would elicit angiogenesis. Animals were HWDS-conditioned (Conditioned) or shamstimulated (Sham) (n D 5/group) daily for 3 weeks. The contralateral limb in both groups served as the control. Each animal was injected with bromodeoxyuridine (BrDU). After 3 weeks, rats were anesthetized and iliac artery blood flow was measured bilaterally before, during, and after acute HWDS. HWDS of the Conditioned limbs elicited a 247% increase in blood flow above resting conditions compared to a 200% increase in control legs. Sham animals did not demonstrate between-leg differences in flow. Hindlimb musculature staining for BrDU revealed angiogenesis in Conditioned versus Sham groups. Flow changes accompanying HWDS corroborated earlier microvascular findings demonstrating a significant ...
How to Increase Blood Flow. Poor circulation and blood flow often cause cool extremities, discolored extremities, and edema (swelling). You may also notice that your feet and hands fall asleep often. To increase blood flow to your entire...
Forearm and calf blood flow will be measured independently by venous occlusion plethysmography using mercury-in-silastic strain gauges. Plethysmographic measurements will be made at rest and following 5 minutes of ischemia (reactive hyperemia) of the distal limb (forearm and calf). Peak blood flow will be determined as the highest flow recorded during the post deflation period. Total blood flow will be measured as the area under the time-curve after resting flow is subtracted. Vascular conductance will be calculated using blood flow/mean arterial pressure (via finger plethysmograph ...
Extracellular adenosine triphosphate (ATP) stimulates vasodilation by binding to endothelial ATP-selective P2Y2 receptors; a phenomenon, which is posited to be accelerated during exercise. Herein, we used a rat model to examine how different dosages of acute oral ATP administration affected the femoral blood flow response prior to, during, and after an exercise bout. In addition, we performed a single dose chronic administration pilot study in resistance trained athletes. Animal study: Male Wistar rats were gavage-fed the body surface area, species adjusted human equivalent dose (HED) of either 100 mg (n=4), 400 mg (n=4), 1,000 mg (n=5) or 1,600 mg (n=5) of oral ATP as a disodium salt (Peak ATP®, TSI, Missoula, MT). Rats that were not gavage-fed were used as controls (CTL, n=5). Blood flow was monitored continuously: a) 60 min prior to, b) during and c) 90 min following an electrically-evoked leg-kicking exercise. Human Study: In a pilot study, 12 college-aged resistance-trained subjects were given 400
Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans.Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans. ...
24 Holstein calves experimentally infected and female viagra pills 39 Holstein cows naturally infected with Salmonella spp. We review the current treatments available for superficial mycoses and discuss recent developments in pharmacotherapy and the most useful adjuvant treatments. HCC xenograft models were constructed in wild type and IL-17 knockout mice to clarify the effects of IL-17 on HCC in vivo.. The results of this study suggest that increased serum insulin may be associated with decreased cognitive function and dementia in women. A current trial is trying to assess whether the genetically-modified cells generic viagra without subscription walmart will produce daughter cells. In habitual smokers after overnight abstinence, nicotine induced differing effects on regional blood flow relative to whole brain blood flow.. Owing to study heterogeneity, meta-analyses of the endpoint data could not be performed. The major structural proteins of the fresh and decellularized jugular venous valves ...
This prospective, non-randomized, controlled experimental study looks at the effects of NΩ-monomethyl-l-arginine (l-NMMA) on haemodynamics, oxygen transport and regional blood flow in healthy and septic sheep, and compares these effects with those of noradrenaline (NA; norepinephrine). All sheep were chronically instrumented. Six sheep received l-NMMA (7 mg·kg-1·h-1), six sheep received NA, and seven sheep received the carrier alone (0.9% NaCl). The NA dosage was continuously and individually adjusted to achieve the same increase in blood pressure as observed in matched sheep of the l-NMMA group (non-septic phase). Treatment was discontinued after 3 h. Sepsis was initiated and maintained by a continuous infusion of live Pseudomonas aeruginosa. After 24 h of sepsis, the sheep were again challenged over a treatment period of 3 h with their previously assigned drug (septic phase). During the non-septic phase of the experiment, NA and l-NMMA both caused an increase in mean arterial pressure (MAP) ...
Impaired vascular reactivity and arterial stiffening are manifestations of vascular dysfunction in the presence of CV risk factors or established CV disease. Whereas stiffening predominantly affects the central elastic arteries, impaired reactivity to various stimuli can be demonstrated in the microvasculature and conduit arteries of several arterial beds. The results of the present study demonstrate that impaired forearm microvascular function and brachial artery reactivity are associated with increased arterial stiffness.. Normal resting flow and hyperemic response reflect the integrity of vascular function in the microcirculation. Elevated resting forearm blood flow may represent a state of hyperperfusion, analogous to the increased renal blood flow and glomerular hyperfiltration noted in early stages of diabetes,18 essential hypertension,19 and obesity.20 Reactive hyperemia is attributable mainly to ischemia-induced local release of vasodilator substances, including nitric oxide.21,22 We23 ...
in Veterinary Research Communications (1992), 16(6), 453-464. The lungs of 13 healthy Landrace piglets were isolated, perfused and maintained in an isogravimetric state under zone III conditions. By applying vascular occlusion methods, the total blood flow ... [more ▼]. The lungs of 13 healthy Landrace piglets were isolated, perfused and maintained in an isogravimetric state under zone III conditions. By applying vascular occlusion methods, the total blood flow resistance (Rt) was partitioned into four components: arterial (Ra), pre- (Ra) and post-capillary (Rv), and venous (Rv). The capillary filtration coefficient (Kfc) was evaluated using a gravimetric technique. A bolus of 55 micrograms of Escherichia coli endotoxins (LPS) per 100 g of lung was injected into the arterial reservoir of eight lungs, followed by an infusion of LPS at a rate of 55 micrograms per 100 g of lung per hour for 180 min. A bolus of theophylline (85 mg per 100 g of lung weight) was injected into the arterial ...
Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATPsensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood ves-
Sixteen subjects closed their eyes and visualized uppercase letters of the alphabet at two sizes, as small as possible or as large as possible while remaining visible. Subjects evaluated a shape characteristic of each letter (e.g., whether it has any curved lines), and responded as quickly as possible. Cerebral blood flow was normalized to the same value for each subject, and relative blood flow was computed for a set of regions of interest. The mean response time for each subject in the task was regressed onto the blood flow values. Blood flow in area 17 was negatively correlated with response time (r = -0.65), as was blood flow in area 19 (r = -0.66), whereas blood flow in the inferior parietal lobe was positively correlated with response time (r = 0.54). The first two effects persisted even when variance due to the other correlations was removed. These findings suggest that individual differences in the activation of specific brain loci are directly related to performance of tasks that rely ...
Pomegranates are juicy, sweet fruits that are particularly high in … This study also found this and found that vitamin D3 could reduce atherogenesis, the buildup of fatty plaques in arteries. Curcumin is the primary active ingredient in turmeric - a powerful superfood that helps prevent a variety of diseases such as cancer. Research further shows that L-arginine supplements help reduce blood pressure levels. Blood clots: A blood clot is a good thing when it forms at the site of a wound and staunches blood flow. To improve blood flow, a person can take the following natural supplements: 1. Vitamin B3 Also known as niacin, vitamin B3 helps improve the … Best Supplements to Increase Blood Flow and Circulation 1. We utilize Live blood analysis since 2004, conventional as well as specialty laboratories for a thorough diagnostic work up of the disease in question. Cause dilation of the arteries to help increase blood flow. Fortunately, blood flow and heart health can both be improved with some ...
An image processing apparatus includes an identification unit configured to identify a retinal blood vessel based on a retinal image, a measurement unit configured to measure blood flow information for the blood vessel based on the retinal image, and a display control unit configured to display the measured blood flow information by at least one selected from a depth of the identified blood vessel, a size of the identified blood vessel, and a combination of both.
Circulatory system diagram , new health advisor at muscles. Diagram Of Heart Showing Blood Flow welcome in order to our blog site, in this moment I will provide you with with regards to Diagram of heart showing blood flow.. And from now on, this is actually the 1st photograph, diagram of heart showing blood flow, diagram of the human heart showing blood flow, labeled diagram of the heart showing blood flow, diagram of the heart showing direction of blood flow, diagram of heart and blood flow through lungs :. ...
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The magnesium content of many diets falls short; this important mineral may be critical for good blood flow dynamics which support fertility and implantation. - Magnesium And Uterine Blood Flow - Infertility at BellaOnline
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Wentland AL, Artz NS, Fain SB, Grist TM, Djamali A, Sadowski EA. MR measures of renal perfusion, oxygen bioavailability and total renal blood flow in a porcine model: noninvasive regional assessment of renal function. Nephrol Dial Transplant. 2012 Jan; 27(1):128-35 ...
An echocardiogram is a test which uses sound waves (ultrasound) to examine the heart. This is the same method used on a pregnant woman to look at her baby, but the echocardiogram looks at your heart instead.
Objective: Extra cellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation but the extent to which the vasodilatatory capacity of nucleotides and nucleosides are affected in type 2 diabetes is unknown. The present study investigated: 1) the vasodilatatory effect of ATP, UTP, and adenosine (ADO) and 2) the expression and distribution of P2Y2 and P2X1 receptors in skeletal muscles of diabetic subjects.. Research Design and Methods: In 10 diabetic patients and 10 age-matched controls, leg blood flow (LBF) was measured during intrafemoral artery infusion of ATP, UTP, and ADO eliciting a blood flow equal to knee-extensor exercise at 12 watts (∼2.6 L/min).. Results: The vasodilatatory effect of the purinergic system was 50 % lower in the diabetic group as exemplified by a LBF increase by 274±37 vs. 143±26 ml/μ;mol ATP x kg; by 494±80 vs. 234±39 ml/μmol UTP x kg; and by 14.9±2.7 vs. 7.5±0.6 ml/μmol ADO x kg in ...
Exercise and Increased Blood Flow - As you exercise, your body increases blood flow to your working muscles. See how your nervous system gets the blood flow to the right place.
Synonyms for Blood flow in Free Thesaurus. Antonyms for Blood flow. 141 synonyms for flow: run, course, rush, sweep, move, issue, pass, roll, flood, pour, slide, proceed, stream, run out, surge, spill, go along, circulate, swirl. What are synonyms for Blood flow?
Laser speckle imaging (LSI) is widely used to study blood flow at high spatiotemporal resolution. Several papers recently pointed out that the commonly used LSI equation involves an approximation that could result in incorrect data analysis. We investigated the impact of such an approximation and introduced a simplified analysis method to improve computation time. Flow phantom studies were performed for validation. Moreover, we demonstrated a novel LSI application by imaging blood flow of rat retinas under normal and physiologic-challenge conditions. Because blood-flow abnormality is implicated in many retinal diseases, LSI could provide valuable physiologic, and potentially diagnostic, information.. © 2007 Optical Society of America. Full Article , PDF Article ...
DESCRIPTION (provided by applicant): In order for a tumor to grow, it must obtain nutrients and oxygen from its host and continuously evolve new vasculature to deliver supplies to its multiplying cells. Exciting current research studies of interventions that reduce or reverse malignant growth of tumors using angiogenesis inhibitors and vasoactive compounds that modify tumor blood flow. Research in this important area can be advanced by access to instruments and methods that visualize and quantify properties of tumor vasculature. This project involves the development of an instrument to measure both regional blood flow and vascular structure in tumors from experimental animals and produce high-resolution, three-dimensional distribution maps of these important tumor characteristics. The instrument will provide cancer research laboratories with a tool for quantifying these properties at various stages of tumor development and treatment. The specific analysis software to display and quantify tumor ...
Like every other organ in your body, your eyes require oxygenated blood to function properly. When there is too much pressure inside the eye and compromised blood flow, problems like glaucoma can occur. Your vision may become altered too. Improving vascular function for your eyes is important.
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Each vascular bed determines its own blood flow, with few exceptions (the skin and most notably the pulmonary circulation). This is based on the fact that most vascular beds change their vascular resistance to regulate flow through the organ. If there is increasing metabolic demand by an organ, flow increases to meet this demand, venous return from the organ increases, and in turn venous return to the heart increases. Thus cardiac output is the sum of the flow through individual autoregulating vascular beds that are all determining their own flow in independent fashion. 145 The organs most frequently cited as demonstrating autoregulatory activity include the brain, myocardium, kidneys, and retina. These are survival organs, essential for the stress response. Beyond autoregulation, there are other local influences that augment regional blood flow during increased metabolic activity or cardiac output. FIGURE 2-19 The generalized autoregulatory curve of flow (Q) versus pressure. Flow remains ...
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An implantable device for regulating blood flow through a blood vessel comprising an elongated support dimensioned and configured to be implanted in a blood vessel. The support includes a linking member linking axially spaced apart portions to one another. A valve membrane extends between the axially spaced apart support portions and includes first region folded over the first linking member and attached thereto and a second region adjacent the first region and unattached to the first linking member. The second region is movable between a first position to enable blood flow and a second position to inhibit blood flow.
An implantable device for regulating blood flow through a blood vessel comprising an elongated support dimensioned and configured to be implanted in a blood vessel. The support includes a linking member linking axially spaced apart portions to one another. A valve membrane extends between the axially spaced apart support portions and includes first region folded over the first linking member and attached thereto and a second region adjacent the first region and unattached to the first linking member. The second region is movable between a first position to enable blood flow and a second position to inhibit blood flow.
Subtle but profound changes in blood flow within the brain may be among the earliest signs of Alzheimers disease, according to a review of recent research conducted by Dr. Costantino Iadecola, Chief of the Division of Neurobiology at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, in New York City.. These vascular changes are very early markers of disease, and can be used very effectively to diagnose patients early on, said Dr. Iadecola, who is the George C. Cotzias Distinguished Professor of Neurology and Neuroscience at Weill Cornell Medical College, and Attending Neurologist at NewYork-Presbyterian/Weill Cornell. Early diagnosis is important, he said, because the earlier you start treatment, the better youre going to be. His review of more than 150 published studies on Alzheimers-linked vascular changes appeared in the May issue of Nature Reviews/Neuroscience.. Over the past few decades, research into the causes of Alzheimers has focused primarily on the activity of the ...
By JANELLE PERALEZ GUNN and LAUREN E. OWENS Your body needs a small amount of sodium to work properly, but excess sodium can lead to high blood pressure (also known as hypertension), which can harden your arteries and decrease blood flow to your heart. This decrease in blood flow can cause a number of other ...
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TY - JOUR. T1 - Post-exercise blood flow restriction attenuates hyperemia similarly in males and females. AU - Dankel, Scott J. AU - Mouser, J Grant. AU - Jessee, Matthew B. AU - Mattocks, Kevin T. AU - Buckner, Samuel L. AU - Loenneke, Jeremy P. PY - 2017/8. Y1 - 2017/8. N2 - PURPOSE: Our laboratory recently demonstrated that post-exercise blood flow restriction attenuated muscle hypertrophy only in females, which we hypothesized may be due to alterations in post-exercise blood flow. The aim of this study is to test our previous hypothesis that sex differences in blood flow would exist when employing the same protocol.METHODS: Twenty-two untrained individuals (12 females; 10 males) performed two exercise sessions, each involving one set of elbow flexion exercise to volitional failure on the right arm. The experimental condition had blood flow restriction applied for a 3 min post-exercise period, whereas the control condition did not. Blood flow was measured using an ultrasound at the brachial ...
TY - JOUR. T1 - Hematocrit-insensitive Absolute Blood Flow Rate Measurement in 0.5-mm-diameter Flow Channel Using MEMS-based Laser Doppler Velocimeter with Signal Modification for Detecting Beat Frequency from Broad Power Spectrum. AU - Morita, Nobutomo. AU - Iwasaki, Wataru. AU - Nogami, Hirofumi. AU - Nakashima, Fumiya. AU - Higurashi, Eiji. AU - Sawada, Renshi. N1 - Funding Information: Part of this work was supported by JSPS KAKENHI, Grant Number JP16J04014.. PY - 2018. Y1 - 2018. N2 - We applied our millimeter-scale laser Doppler velocimeter (µ-LDV) as an absolute blood flow rate sensor in a thin tube (0.5 mm inner diameter) for precise control of the blood flow rate. We proposed a sequence of signal processing, frequency weighting modification, and peak detection, and succeeded in the detection of the beat signal induced by flow at the center of the tube. Flow rates of 20, 40, and 60% hematocrit [volume percentage of red blood cells (RBCs) in blood] were measured. The errors with respect ...
The results from this study, using the coloured microsphere technique to measure flow, produced values for resting flows in all tissues that compared well to measurements made by other workers using either radio-labelled, or coloured, microspheres to measure flow in rats (Malik et al., 1976; Ishise et al., 1980; Wicker & Tarazi, 1982; Hakkinen et al., 1995). Our observations substantiate the finding of Hakkinen et al. (1995) that coloured microspheres are a suitable alternative to radio-labelled spheres for measuring blood flow in rats.. In our previous study (Kemp et al., 1993) we found that ET-1 caused a fall in common and internal carotid blood flow, and infusion of MgSO4 caused flow to increase in both vessels, in the presence of ET-1. Torregrosa et al., (1994) showed that ET-1 caused a reduction in cerebral blood flow in the conscious goat, but found that MgSO4 caused an increase in flow, in the presence of ET-1, only when given directly into the cerebroarterial supply, and not when given ...
TY - JOUR. T1 - Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. AU - Fry, Christopher. AU - Glynn, Erin L.. AU - Drummond, Micah J.. AU - Timmerman, Kyle L.. AU - Fujita, Satoshi. AU - Abe, Takashi. AU - Dhanani, Shaheen. AU - Volpi, Elena. AU - Rasmussen, Blake. PY - 2010/5. Y1 - 2010/5. N2 - The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and dependence. Resistance exercise (RE) is an effective rehabilitation technique that can improve muscle mass and strength; however, older individuals are resistant to the stimulation of muscle protein, synthesis (MPS) with traditional high-intensity RE. Recently, a novel rehabilitation exercise method, low-intensity RE, combined with blood flow restriction (BFR), has been shown to stimulate mammalian target of rapamycin complex 1 (mTORC1) signaling and MPS in young men. We hypothesized that low-intensity RE with BFR would be able to activate mTORC1 signaling and ...
Johnny Owens, BS,MPT. is CEO and Director of Clinical Education for Owens Recovery Science, a corporation recognized in the INC 500. He manages a research portfolio of over 40 clinical trials being conducted worldwide primarily studying the effects of Blood Flow Restriction Rehabilitation in clinical populations. He is the former Chief of Human Performance Optimization at the Center for the Intrepid (CFI) at San Antonio Military Medical Center and continues to serve as a consultant and clinical researcher at the CFI. He completed his undergraduate course work in Biology at The University of Texas at Austin and earned his Masters in Physical Therapy at The University of Texas Medical Branch. He serves as a medical consultant for teams in the NFL, NBA, MLB, NHL and collegiate sports.. He is involved in numerous clinical trials involving regenerative medicine, sports medicine, blood flow restriction and high-energy trauma. Owens has been published extensively in the peer-reviewed literature, ...
PURPOSE: Prior results have demonstrated a significant reduction in retinal blood flow in streptozotocin (STZ)-induced diabetic rats. These studies were extended to investigate whether retinal blood flow changes, in the diabetic rat model, could be prevented with strict glycemic control using insulin pumps. Retinal blood flow changes also were measured during hyperoxia and after intravitreal histamine infusion to validate the methodology. METHODS: Retinal blood flow changes were measured using video-based fluorescein angiography and computer-assisted image analysis. A total of 48 male Sprague-Dawley and 9 Brown Norway rats were used in these experiments. Retinal blood flow after primary insulin intervention was evaluated in diabetic rats implanted with mini-osmotic insulin pumps within 24 hours of STZ-induced diabetes. Diabetic rats, not treated with insulin, were used for comparison. RESULTS: Hyperoxia caused a significant (P = 0.001) reduction (54%) in retinal blood flow, whereas intravitreal ...
Purpose: To assess tissue oxygenation, along with metabolic and physiological responses during blood flow restriction (BFR, bilateral vascular occlusion) and systemic hypoxia conditions during submaximal leg- versus arm-cycling exercise. Methods: In both legs and arms, 4 randomized sessions were performed (normoxia 400 m, fraction of inspired oxygen [FIO2] 20.9% and normobaric hypoxia 3800 m, FIO2 13.1% [0.1%]; combined with BFR at 0% and 45% of resting pulse elimination pressure). During each session, a single 6-minute steady-state submaximal exercise was performed to measure physiological changes and oxygenation (near-infrared spectroscopy) of the muscle tissue in both the vastus lateralis (legs) and biceps brachii (arms). Results: Total hemoglobin concentration ([tHb]) was 65% higher (P , .001) in arms versus legs, suggesting that arms had a greater blood perfusion capacity than legs. Furthermore, there were greater changes in tissue blood volume [tHb] during BFR compared with control ...
TY - JOUR. T1 - Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition. AU - Meyer, J.. AU - Hinder, F.. AU - Stothert, J.. AU - Traber, L. D.. AU - Herndon, David. AU - Flynn, J. T.. AU - Traber, D. L.. PY - 1994. Y1 - 1994. N2 - We evaluated regional blood flows in a hyperdynamic sepsis model and the reversal of increased flows by blockade of nitric oxide (NO) synthase. Seven awake sheep were continuously infused with Escherichia coli endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1] for 48 h. The NO synthase inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME, 25 mg/kg) was injected after 24 h. Blood flows to systemic organs were determined with the radioactive microsphere technique. LPS induced elevation of cardiac index by 36% (P , 0.05) and a fall in systemic vascular resistance index by 37% (P , 0.05) at 0 h [time of L-NAME administration, 24 h after infusion of LPS had begun]. L-NAME administration normalized cardiac index [6.1 ± ...
by Coach ROBERT HAVILAND MS,BS PT,CSCS,CES. Blood Flow Restriction (BFR) training is an exercise technique that manipulates the bodys circulatory system, and when combined with exercise, produces rapid gains in strength and fitness using light-weights in a very short period of time.. BFR training induces an anabolic response through various pathways perhaps the most important of which is by preferentially targeting the large fast twitch muscle fibers. Fast twitch fibers are the biggest muscle fibers and have the most potential for growth. These fibers are recruited last during contractions and are mostly anaerobic (dont use oxygen) whereas the smaller slow twitch fibers are recruited first during contractions and are aerobic (use oxygen). Slow twitch fibers have a much smaller potential for growth compared to fast twitch fibers. BFR training restricts blood flow to muscles, pre-fatiguing the slow twitch fibers and forcing the anaerobic fast twitch fibers to handle the load even at low ...
We present a novel application of optical microangiography (OMAG) imaging technique for visualization of depth-resolved vascular network within retina and choroid as well as measurement of total retinal blood flow in mice. A fast speed spectral domain OCT imaging system at 820nm with a line scan rate of 140 kHz was developed to image the posterior segment of eyes in mice. By applying an OMAG algorithm to extract the moving blood flow signals out of the background tissue, we are able to provide true capillary level imaging of the retinal and choroidal vasculature. The microvascular patterns within different retinal layers are presented. An en face Doppler OCT approach [Srinivasan et al., Opt Express 18, 2477 (2010)] was adopted for retinal blood flow measurement. The flow is calculated by integrating the axial blood flow velocity over the vessel area measured in an en face plane without knowing the blood vessel angle. Total retinal blood flow can be measured from both retinal arteries and veins. ... : BFR Bands PRO X Blood Flow Restriction Bands - Set of 2 Occlusion Training Straps w/ Pinch-Free Buckle - Arms & Legs Workout for Men and Women, 2
The American College of Sports Medicine (ACSM) guidelines state that during resistance training clients must use a weight of at least 70% of their 1 repetition maximum (RM) to improve strength and hypertrophy. However, for our injured and recovering populations this may not be an option.. Blood Flow Restriction (BFR) rehabilitation can induce a similar strength and hypertrophy response in individuals by exercising at 20% of their 1 Repetition Maximum. Research shows that the increase in metabolic by-products from anaerobic metabolism seems to play as powerful a role in muscle physiology as the mechanical load itself.. We have found this method of rehabilitation to be beneficial in maintaining strength and muscle size post injury with low-level exercise and to build sufficient strength without having to heavily load the injured muscles and/or joints. It has been an adjunct to transition clients and bridge the gap between rehabilitation and performance.. ...
We sought to determine if blood flow restriction (BFR) by itself or in combination with exercise would result in prolonged decrements in torque when using restriction pressures relative to the participants limb size. Sixteen participants were random
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There was a time when getting a good pump meant lifting really heavy weights, which are at least 80% of your one-rep-max. That was until blood flow restriction training or BFR training came into the limelight.
Blood flow restriction has gained a lot more attention recently, and its certainly an area of interest for me as I have asked the question how useful it would be when applied as a tool for patients suffering with persistent pain. So what better way of getting an understanding than by asking the experts.
TY - JOUR. T1 - Facial Blood Flow Responses to Dynamic Exercise. AU - Hayashi, Naoyuki. AU - Kashima, Hideaki. AU - Ikemura, Tsukasa. N1 - Funding Information: This work was supported by JSPS KAKENHI grant number 282163 to N.H. Publisher Copyright: © 2021 Georg Thieme Verlag. All rights reserved.. PY - 2021/3/1. Y1 - 2021/3/1. N2 - We reported previously that a static handgrip exercise evoked regional differences in the facial blood flow. The present study examined whether regional differences in facial blood flow are also evoked during dynamic exercise. Facial blood flow was measured by laser speckle flowgraphy during 15 min of cycling exercise at heart rates of 120 bpm, 140 bpm and 160 bpm in 12 subjects. The facial vascular conductance index was calculated from the blood flow and mean arterial pressure. The regional blood flow and conductance index values were determined in the forehead, eyelid, nose, cheek, ear and lip. One-way ANOVA and Tukeys post-hoc test were used to examine effects of ...
DC Lindsay, D Clarke, DR Holdright, IS Anand, PA Poole-Wilson, P Collins; Vasomotor Control of Femoral Artery Blood Flow is Impaired in Chronic Heart Failure. Clin Sci (Lond) 1 July 1992; 83 (s27): 6P. doi: Download citation file:. ...
TY - JOUR. T1 - Airway blood flow distribution and lung edema after histamine infusion in awake sheep. AU - Kramer, G. C.. AU - Lindsey, D. C.. AU - Wu, C. H.. AU - Mertens, S.. AU - Russell, L. A.. AU - Cross, Carroll E. PY - 1988. Y1 - 1988. N2 - The present study was designed to evaluate the distribution of bronchial blood flow to major airways and peripheral lung and to quantitate lung edema during a 2-h histamine infusion (2 μg·kg-1·min-1) in unanesthetized sheep. By the use of radioactive microspheres, the blood flow to trachea and to tracheal cartilage, smooth muscle, and mucosa/submucosa was determined along with measurements of blood flow to different sized airway segments and the systemic blood flow to lung parenchyma. Histamine greatly increased blood flow to medium-sized (5- to 10-mm-diam) central airways in which blood flow increased 5-10 times base line, whereas in small (1- to 5-mm-diam) central airways the increase was 10-15 times. Blood flow in tracheal mucosa/submucosa ...
Laser speckle flowmetry (LSF) was initially developed to measure blood flow in the retina. More recently, its primary application has been to image baseline blood flow and activity-dependent changes in blood flow in the brain. We now describe experiments in the rat retina in which LSF was used in conjunction with confocal microscopy to monitor light-evoked changes in blood flow in retinal vessels. This dual imaging technique permitted us to stimulate retinal photoreceptors and measure vessel diameter with confocal microscopy while simultaneously monitoring blood flow with LSF. We found that a flickering light dilated retinal arterioles and evoked increases in retinal blood velocity with similar time courses. In addition, focal light stimulation evoked local increases in blood velocity. The spatial distribution of these increases depended on the location of the stimulus relative to retinal arterioles and venules. The results suggest that capillaries are largely unresponsive to local neuronal activity and
The purpose of this study was to develop a rapid protocol for noninvasive quantification of blood flow at intraoral sites by laser Doppler flowmetry. For each flow measurement, the lowest flow observed over a 30-s period was recorded. Three flow readings at each site were averaged and recorded. Forehead and dorsal right-hand blood flows measured agreed with previous laser Doppler flow measurements. Flows measured with a hand-held probe were not different from flows measured with a stent-stabilized probe on the attached gingiva and an adhesive-stabilized probe on the dorsal hand. High flows were found in the tongue, buccal mucosa, and buccal vestibule. Medium flows were found in the attached gingivae. The lowest flows were found in the teeth. These results indicate that flow in intraoral tissues varies by site and can be noninvasively quantified with the laser Doppler flowmeter when a rigorous measurement protocol is used ...
Background: During aging, a significant loss of muscle mass, strength, and power is associated with a decline in daily functional capacities. Traditionally, resistance training is prescribed to prevent or reverse the skeletal muscle weakness, but the required training intensity may be too demanding for older people with poor physical performance. Resistance exercise with blood flow moderation (KAATSU training), originally developed in Japan, combines resistance exercise with blood flow restriction. It has been reported that KAATSU training enhances muscle hypertrophy in many populations. However, few studies have evaluated the effects of resistance exercises with blood flow restriction in elderly people and how this affects vascular structure and function. Objective: The aim of this study was to evaluate (1) the acute and chronic effects of resistance exercise with blood flow restriction on vascular health in elderly people with low gait speed and (2) whether low-load resistance training with ...
A reduction in body temperature is considered to be the primary mechanism by which cold water immersion (CWI) enhances short-term (h) recovery and improves exercise capacity in the heat. However, improvement in exercise performance may be optimised at a given cooling magnitude. Water temperature and immersion duration influence the magnitude of cooling in the core body, muscle and skin. Given the role of blood flow in convective heat flux, substrate delivery and metabolic waste clearance, it is important to understand the influence of different water temperatures on compartmental distribution of limb blood flow during CWI. Therefore, the purpose of this study was to compare blood flow changes in the common femoral artery, vastus lateralis muscle, and thigh skin induced by 5 min of post-exercise water immersion at 8°C, 14°C, 35°C or passive rest. In a randomised manner, nine recreationally active men performed exhaustive cycling in a climate control chamber (32.8 ± 0.4°C and 32 ± 5%rh), followed by
DUBLIN, Ireland, February 21, 2014 /PRNewswire/ --. Research and Markets ( has announced the addition of the Blood Flow Measurement Devices Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 report to their offering.. (Logo: ). Blood flow measurement devices are used for measuring the volume rate of blood flow in the blood vessels of the body. The vascular assessment data obtained through the blood flow measurement devices helps physicians to maintain the equilibrium between supply and demand of tissue oxygen of patients. Rising incidence rate of circulatory diseases and metabolic disorders are fueling the growth of these devices market. According to the Centers for Disease Control and Prevention (CDC) in the year 2012, approximately 8,000,000 people in the United States had peripheral arterial disease (PAD); that includes 12-20% of population older ...
Muscle fatigue is defined as a reduction in the force generating capacity of a muscle or group of muscles. Local muscular fatigue is attenuated with exercise training, and there is some evidence that blood flow kinetics during exercise are also enhanced with training. This study aimed to further explore the relationship between fatigue and blood flow by assessing the kinetics of fatigue and blood flow during forearm (hand grip) exercise before and after a four week training period. Existing techniques for the measurement of blood flow during exercise are invasive or only measure flow through a single artery. A secondary aim of the present study was to explore the use of strain gauge plethysmography for the measurement of forearm blood flow during exercise.
Continuous balloon occlusion of the descending aorta is an experimental method that may improve blood flow to the myocardium and the brain during cardiopulmonary resuscitation (CPR). The aim of the present investigation was to evaluate the effects of this intervention on haemodynamics and the frequency of restoration of spontaneous circulation. Ventricular fibrillation was induced in 39 anaesthetised piglets, followed by an 8-min non-intervention interval. In a haemodynamic study (n = 10), closed chest CPR was performed for 7 min before the intra-aortic balloon was inflated. This intervention increased mean arterial blood pressure by 20%, reduced cardiac output by 33%, increased coronary artery blood flow by 86%, and increased common carotid artery blood flow by 62%. All these changes were statistically significant. Administration of epinephrine further increased mean arterial blood pressure and coronary artery blood flow, while cardiac output and common carotid artery blood flow decreased. In a ...
BFR is a state-of-the-art rehab concept that we are utilizing to improve rehab outcomes. We utilize tourniquets and low-level exercise to alter blood flow dynamics in order to create a cellular and metabolic environment that replicates what happens in the body at high levels of exercise. This allows the body to build muscle while exercising at a low level. This is helpful when we have an individual who may not be able to exercise at the level that is necessary to build muscle. For example, individuals who are post-surgery or individuals who cannot perform higher level exercise without pain because of diagnoses like tendinopathies, osteoarthritis, etc.. ...
TY - JOUR. T1 - Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows. T2 - An Experimental Study. AU - Thomassen, Sisse Anette. AU - Kjærgaard, Benedict. AU - Olsen Alstrup, Aage Kristian. AU - Munk, Ole Lajord. AU - Frøkiær, Jørgen. AU - Larsson, Anders. AU - Rasmussen, Bodil Steen. N1 - Copyright © 2017 Elsevier Inc. All rights reserved.. PY - 2017/12/6. Y1 - 2017/12/6. KW - Journal Article. U2 - 10.1053/j.jvca.2017.03.027. DO - 10.1053/j.jvca.2017.03.027. M3 - Journal article. C2 - 28693932. VL - 31. SP - 2065. EP - 2071. JO - Journal of Cardiothoracic and Vascular Anesthesia. JF - Journal of Cardiothoracic and Vascular Anesthesia. SN - 1053-0770. IS - 6. ER - ...
1. Local regulation of subcutaneous blood flow in the forearm was studied in the acute phase of myocardial infarction. Blood flow was measured by the local 133Xe-washout technique.. 2. Plasma concentrations of noradrenaline and adrenaline were increased on day 1, suggesting an increase in sympathetic neuronal activity, but gradually returned to normal thereafter.. 3. Subcutaneous blood flow on day 1 was far below normal (38%) and steadily increased to reach normal at day 7 after coronary occlusion. The sympathetic vasoconstrictor activity that caused the initial reduction in flow could be blocked by proximal nervous blockade, increasing the subcutaneous blood flow by 130, 63 and 14% on days 1, 3 and 7 respectively after coronary occlusion. A normal response to decrease in arterial perfusion pressure was observed, suggesting that intrinsic vascular reactions responsible for autoregulation of blood flow were not affected by the increase in sympathetic vasoconstrictor activity. The vasoconstrictor ...
Monkshood root expansion of peripheral vascular function, Monkshood Decoction can markedly dilated blood vessel in anesthetized dogs and cats, Monkshood Decoction has the function of. Intravenous injection of water-soluble fraction of 7.5, 15 and 30mg / kg, can make the anesthetized dog femoral artery blood flow was increased by 30, 70 and 129%, resistance is…
Norma Devine, Editor. On Wednesday, February 27, 2002, Dr. Elliot Werner, a glaucoma specialist at Wills, and the glaucoma chat group discussed Blood Flow & Glaucoma.. Moderator: Good evening, Dr. Werner.. Dr. Elliot Werner: Hello, everybody. Let me warn you right off the bat. I am no expert on the subject of blood flow.. Moderator: Thanks for the warning, Doctor Werner. Would you prefer to discuss a different topic?. Dr. Elliot Werner: No. Ill do my best.. P: Whatever you tell us will be helpful.. Dr. Elliot Werner: Ill start. Blood flow refers to the quality and quantity of the circulation of blood through the eye.. Moderator: Lutein was touted as being good, I think, for macular degeneration or something else. Might it have some beneficial effect relating to blood flow and glaucoma? Dr. Elliot Werner: Not that Im aware of.. Moderator: Is there any test that can visualize blood flow in the eye?. Dr. Elliot Werner: There are some tests that can measure blood flow in different parts of the ...
The results of studies utilizing the nitrous oxide technic for measuring cerebral blood flow have been reviewed and divided into three groups: (1) those in which cerebral blood flow and metabolism were normal, (2) those in which cerebral blood flow was increased, and (3) those in which cerebral blood flow and metabolism were decreased. The factors which apparently regulate and control cerebral blood flow and metabolism are reviewed and discussed.. ...
The movement of blood through the vessels. It is pulsatile in the large arteries, diminishing in amplitude as it approaches the [capillaries. In the veins it is nonpulsatile. The flow in arteries is the result of ventricular ejection; in the veins it is a result of a number of factors including respiratory movement, muscle compression and the small residuum of arterial pressure. Effective renal blood flow (ERBF) That portion of the total blood flow through the kidneys that perfuses functional renal tissue such as the glomeruli. Laminar blood flow Blood flowing through a large blood vessel moves forward in a series of concentric laminae that slide over each other like a telescoping radio aerial. The central lamina moves fastest; the outer layer may be stationary. Renal blood flow, effective The amount of blood flowing to the parts of the kidney that are involved with the production of constituents of urine. It is that portion of the total renal blood flow that perfuses functional renal tissue ...
TY - JOUR. T1 - Skin blood flow in the Wistar-Kyoto rat and the spontaneously hypertensive rat. AU - Rendell, Marc S.. AU - Mcintyre, Steven F.. AU - Terando, John V.. AU - Kelly, Stephen T.. AU - Finney, David A.. N1 - Funding Information: Acknowledgement-This work was supported by a grant from the American Heart Association, Nebraska Affiliate.. PY - 1993/10. Y1 - 1993/10. N2 - 1. 1. Using laser Doppler techniques in man, we have previously demonstrated differences in skin blood flow properties at sites with primarily nutritive (NUTR) perfusion, such as the elbow or knee, as compared to sites such as the finger pulp, with predominantly arteriovenous anastomotic (AVA) perfusion. 2. 2. Basal and heat stimulated flow is greater at AVA sites. In man, blood pressure changes are reflected primarily by changes at AVA rather than NUTR sites. 3. 3. These blood pressure induced changes affect the red blood cell velocity (VEL) component at AVA sites more than microvascular volume (VOL). 4. 4. Given these ...
TY - JOUR. T1 - Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. AU - Armstead, W. M.. AU - Mirro, R.. AU - Busija, D. W.. AU - Leffler, Charles. PY - 1991/1/1. Y1 - 1991/1/1. N2 - The interaction between opioid and prostanoid mechanisms in the control of cerebral hemodynamics was investigated in the conscious hypotensive piglet. Radiomicrospheres were used to determine regional cerebral blood flow (rCBF) in piglets pretreated with the opioid receptor antagonist, naloxone, or its vehicle, saline, during normotension, hypotension, and after the administration of indomethacin, a cyclooxygenase inhibitor, during hypotension. Hemorrhage (30 ml/kg) decreased systemic arterial pressure from 68 ± 12 to 40 ± 10 mm Hg but did not decrease blood flow to any brain region. Indomethacin treatment (5 mg/kg) of hypotensive piglets decreased blood flow to all brain regions within 20 min; this decrease blood flow to all brain regions within 20 rebral vascular ...
Electrophysiological and molecular studies have established the presence of KIR2.1 channels in isolated vascular smooth muscle.7,8,23⇓⇓ However, KIR channels are blocked by Ca2+ and Mg2+,9 each present in millimolar concentrations in extracellular fluid, and other signal transduction mechanisms could overwhelm any contribution to basal tone from KIR in vivo. Ba2+ can be used to probe the functional role of KIR channels.2 We investigated the possible role of KIR channels in human resistance vasculature in vivo by using brachial artery administration of BaCl2 with bilateral measurement of forearm blood flow. Doses were selected to produce concentrations that are pharmacologically active locally in the infused forearm but not systemically, and no significant effects on blood pressure or on blood flow in the contralateral (noninfused) forearm were observed. The dose of Ba2+ administered during each study was less than the daily reference dose, and no adverse effects were observed. The mean ...
TY - JOUR. T1 - Relative dispersion in the Liguro-Provençal basin. T2 - From sub-mesoscale to mesoscale. AU - Schroeder, K.. AU - Haza, A. C.. AU - Griffa, A.. AU - Özgökmen, T. M.. AU - Poulain, P. M.. AU - Gerin, R.. AU - Peggion, G.. AU - Rixen, M.. PY - 2011/3/1. Y1 - 2011/3/1. N2 - Relative dispersion in the Liguro-Provençal basin (a subregion of the Mediterranean Sea) is investigated using clusters of surface drifters deployed during two Marine Rapid Environment Assessment (MREA) experiments covering different months in 2007 and 2008, respectively. The clusters have initial radii of less than 1km, or an order of magnitude below a typical deformation radius (approximately 10-20km). The data set consists of 45 original pairs and more than 50 total pairs (including chance ones) in the spatial range between 1 and 200km. Relative dispersion is estimated using the mean square separation of particle pairs and the Finite Scale Lyapunov Exponents (FSLEs). The two metrics show broadly consistent ...
We read with great interest the recent comprehensive guidelines for implementation of blood flow restricted resistance exercise (BFR-RE) into sports and clinical practice. The authors provided extensive description of the mechanism, training application and addressed many important safety consideration (Patterson et al., 2019). With the potential of BFR exercise expanded to the clinical settings (such as orthopedics (Hughes et al., 2017) and cardiovascular patients (Kambič, Novaković, Tomažin, Strojnik, & Jug, 2019;Madarame, Kurano, Fukumura, Fukuda, & Nakajima, 2013;Tanaka & Takarada, 2018)), many previous reviews have raised safety concerns (Oliveira et al., 2019;Spranger et al., 2015). These are due to potential peripheral ischemia induced hyperactivity of III and IV nerve afferents that could evoke muscle metabo-and/or mehano-reflex (e.g. the exercise pressor reflex), primarily in cardiovascular patients (Angius & Crisafulli, 2020;Piepoli et al., 2008). Since the guidelines focused mainly on the
Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, ...
Four major, interdependent mechanisms are involved in the control of cerebral blood flow: metabolic coupling: neural control, involving both extrinsic and intrinsic neural pathways: Pco2 and autoregulation. Although this division may be somewhat artificial and these control mechanisms probably operate in concert, it is useful to consider each separately. Metabolic Control Local cerebral blood flow (CBF) is regionally heterogeneous. The varied pattern of CBF is neither random nor related to the anatomic organization of the cerebral vasculature or to known differences in the innervation patterns of the cerebral vessels. Neuronal activity is the principal energy-consuming process in the brain. Local cerebral blood flow adjusts to the level of energy generation; therefore, it is the activity in the neuronal circuits that is the major determinant of variations and regional patterns of cerebral blood flow. Normally there is exquisite coupling between the regional cerebral metabolic demand for oxygen ...
The study will be an open controlled pilot study of 6 patients with early-onset severe preeclampsia. Patients will receive Atenativ in addition to conventional therapy The patients will be followed up within the study until three days after delivery. In addition to conventional therapy, i.v. administration of Atenativ will be given in a dosage aimed to raise the plasma level of AT initially to 120% (1.2 kIU/L) The goal is to achieve and maintain plasma activity of about 100% during two weeks. The dose of Atenativ is based on the actual plasma level of AT measured 2 hours before the dose. During the first two days of treatment plasma samples will be drawn for the measurement of AT activity twice a day, once before and 12 hours after infusion in order to monitor the dosage. Thereafter and until study discontinuation AT will be measured once a day. The treatment will continue for two weeks if plasma AT III is below 100% (1.0 kIU/L).Uterine blood flow is measured before, during and after the AT ...
Functional resistance to graded hypotensive ischemia of various segments of the somatosensory pathway was determined in anesthetized cats by repeated concurrent recordings of regional blood flow measured by hydrogen clearance, and evoked potentials (EPs), of dorsal horn of lumbar spinal cord and cerebral cortex. During normal resting CNS blood flow (CBF), there were significant successive reductions of EP amplitudes, recorded from presynaptic spinal components (634, 424-949 microV; re-linearized mean and 95% confidence limits of log-transformed data) compared to postsynaptic spinal (359, 247-522 microV) and presynaptic cortical (50, 32-79 microV) and to postsynaptic cortical components (33, 22-50 microV). During ischemia amplitudes of EPs in spinal cord and cerebral cortex showed significantly different behaviors. The presynaptic spinal component was virtually independent of regional blood flow down to 12 percent of resting values, the postsynaptic cortical component exhibited strongest positive ...
The normal functioning and viability of the human brain is among other things, dependent upon a close relationship between neuronal electrical activity, metabolism and blood flow. The concept that there exists a tight association between these processes was first proposed by Roy and Sherrington over 100 years ago and has since been corroborated by many studies in humans and animals. In diseased states there is a large amount of evidence to suggest these variables are affected by the injury process. However, very little work has been conducted to determine what effect an insult to the brain has on the relationship between them. This thesis examines the effect of traumatic brain injury and subarachnoid haemorrhage on the relationship between neuronal electrical activity and metabolism (neurometabolic coupling), electrical activity and blood flow (neurovascular coupling) and, blood flow and metabolism (flow-metabolism coupling). These relationships were addressed using a multimodality approach, in ...
We report new results on blood flow modeling over large volumes of cortical gray matter of primate brain. We propose a network method for computing the blood flow, which handles realistic boundary conditions, complex vessel shapes, and complex nonlinear blood rheology. From a detailed comparison of the available models for the blood flow rheology and the phase separation effect, we are able to derive important new results on the impact of network structure on blood pressure, hematocrit, and flow distributions. Our findings show that the network geometry (vessel shapes and diameters), the boundary conditions associated with the arterial inputs and venous outputs, and the effective viscosity of the blood are essential components in the flow distribution. In contrast, we show that the phase separation effect has a minor function in the global microvascular hemodynamic behavior. The behavior of the pressure, hematocrit, and blood flow distributions within the network are described through the depth ...
The characterization of blood flow is important to establish links between the hemodynamics and the occurrence of cardiovascular diseases. This study describes the development of a 3-D computational model able to predict the blood flow along the abdominal aorta, including the renal and iliac branches. Upstream branches in the abdominal aorta lead to more complex flow patterns downstream, intensifying reverse and asymmetric flow patterns. The focus is on the occurrence of reverse flow and the perturbations in blood flow patterns originated by the branches. Results show regions of recirculation in the walls of the abdominal aorta, renal and iliac branches. It is concluded that, the renal branches induces perturbations in blood flow and result in asymmetric velocity profiles.. Copyright © 2008 by ASME ...
BACKGROUND: Limitation of the blood supply to skeletal muscle in chronic heart failure may contribute to the symptoms of fatigue and diminished exercise capacity. The pathophysiology underlying this abnormality is not known. The purpose of this study was to assess the effect of endothelium dependent and independent vasodilator agents on blood flow in the leg of patients with heart failure. METHODS AND RESULTS: Blood flow in the leg was measured in patients with heart failure (n = 20) and compared with that in patients with ischaemic heart disease and normal left ventricular function (n = 16) and patients with chest pain and normal coronary arteries (n = 8). External iliac artery blood flow was measured using intravascular Doppler ultrasound and quantitative angiography. Flow was recorded at rest and in response to bolus doses of the endothelium independent vasodilator, papaverine. Endothelium dependent responses were measured by infusion of acetylcholine and substance P. Mean (SEM) baseline ...
Luteal phase defect is closely tied to poor ovarian blood flow, improving pelvic and ovarian blood flow may help the ovaries to function better. - Boost Blood Flow For Luteal Phase Defect - Infertility at BellaOnline
A dependence on the position of the vessel relative to the location of the placenta was seen. Significant differences were noted when all subgroups were compared (Fig. 17). 1Sl). 27 L-.. 001 n = 71 n = 69 fZB- ~ Internal placental border External placental border ® 0 n = 27 Distant from placenta o Fig. 17. 2 Reproducibility The means and the relative coefficient of variation for the 67% and 90% confidence limits for fetal and uteroplacental blood flow parameters are presented in Table 9. Parameters with a low coefficient of variation show little dispersion about the mean and are most readily reproducible. The median value decreased from 290 ml/kg per minute in pregnancy week 24/0 to 220 mljkg in pregnancy week 40/0 (Fig. 39). - Ratio of mean blood flow volume of fetal common carotid artery to estimated fetal weight showed a decreasing trend until pregnancy week 38/0, followed by a slight increase. The median value changed from 60 ml/kg per minute in pregnancy week 28/0 to 46 ml/kg in ...
To our knowledge, our study is the first to systematically correlate BOLD SI changes to endothelial-mediated blood flow changes in the human forearm. With increasing blood flow, we observed an increase in BOLD SI, with saturation at high blood flow levels. However, after intermittent ischemia, BOLD SI remained elevated even after normalization of blood flow. Because O2 consumption is constant for Po2 levels of ≥1 mm Hg and thus does not account for the observed dissociation, the decay time constant for the BOLD MRI signal may indicate the presence of microvascular oxygen reserve.. Our reactive hyperemia results are consistent with the magnitude and dynamics of BOLD SI-related changes reported previously.10,11 Very recent data by Towse et al also provided evidence for a dissociation of flow and BOLD SI.18 Persisting high values of BOLD SI after blood flow normalization are met by postischemic and even posthyperemic elevations of oxygen saturation of venous blood and tissue oxygen tension.19-21 ...
Blood Flow Metab. 13 (3): 526-30. doi:10.1038/jcbfm.1993.68. PMID 8478410. "Launch of tablet to make life easier for dogs in ... Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (1993). "Effect of propentofylline on regional cerebral glucose ...
Ingvar, David H.; Lassen, Niels A. (1961). "Quantitative determination of regional cerebral blood-flow in man". The Lancet. 278 ... "Radioisotopic assessment of regional cerebral blood flow". Progress in Nuclear Medicine. 1: 376-409. PMID 4567822. Lassen, ... There is a Niels Lassen Award presented by the International Society for Cerebral Blood Flow and Metabolism (ISCBFM). ((The ... Olaf B. Paulson (1997). "Niels A. Lassen, M.D., Ph.D.: 1926-1997". Journal of Cerebral Blood Flow & Metabolism. 17 (10): 1005- ...
Journal of Cerebral Blood Flow and Metabolism. 15 (4): 681-6. doi:10.1038/jcbfm.1995.85. PMID 7790418. Meiniel A (March 2001 ... Rahner-Welsch S, Vogel J, Kuschinsky W (July 1995). "Regional congruence and divergence of glucose transporters (GLUT1) and ... Hypendymal cells and ependymal cells both are secretory in nature; their processes project to local blood vessels and also to ... All capillaries in the central nervous system with a functional blood-brain barrier express glucose transporters (GLUT1). These ...
Journal of Cerebral Blood Flow and Metabolism. 9: 786-794. doi:10.1038/jcbfm.1989.112. PMID 2684992. Blin J, Ray CA, Chase TN, ... Piercey MF (1991). "Regional cerebral glucose metabolism compared in rodents and humans". Brain Research. 568: 215-222. doi: ...
NREM sleep is characterized by decreased global and regional cerebral blood flow. It constitutes ~80% of all sleep in adult ... Mazoyer B, Houdé O, Joliot M, Mellet E, Tzourio-Mazoyer N (September 2009). "Regional cerebral blood flow increases during ... "Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study". Brain. 120 (7): 1173-1197. doi:10.1093/ ... "Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans". The Journal ...
Braun, A. (1 July 1997). "Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study". Brain. 120 (7): ... This triggers the "continual-activation" mechanism to generate a data stream from the memory stores to flow through the ... A 2001 study showed evidence that illogical locations, characters, and dream flow may help the brain strengthen the linking and ... consolidation of semantic memories.[77] These conditions may occur because, during REM sleep, the flow of information between ...
... controlling blood pressure; and modulating the regional flow of blood to tissues. In performing these roles, eicosanoids most ... blood flow to tissues, and/or blood pressure. However, their function and relevancy to human physiology and pathology have not ... The blood vessels engorge and the injury reddens.. Swelling-LTB4 makes the blood vessels more permeable. Plasma leaks out into ... blood platelet aggregation; blood clotting; allergic reactions. NSAIDs inhibit its production to reduce incidence of strokes ...
Kendal, WS (2001). "A stochastic model for the self-similar heterogeneity of regional organ blood flow". Proc Natl Acad Sci U S ... Bassingthwaighte, JB (1989). "Fractal nature of regional myocardial blood flow heterogeneity". Circ Res. 65 (3): 578-590. doi: ... measles epidemiology HIV epidemiology, the geographic clustering of childhood leukemia blood flow heterogeneity the genomic ...
CS1 maint: discouraged parameter (link) Ball, RH; Espinoza, MI; Parer, JT (1994). "Regional blood flow in asphyxiated fetuses ...
Braun, A. (1 July 1997). "Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study". Brain. 120 (7): ...
Gk, Frank; Wh, Kaye; P, Greer; Cc, Meltzer; Jc, Price (November 20, 2000). "Regional Cerebral Blood Flow After Recovery From ... J Cereb Blood Flow Metab 2007 27:1533-1539. PMID 17519979. Lois C, Gonzalez I, Johnson KA, Price JC. PET imaging of tau protein ... Price is also an associate editor of the Journal of Cerebral Blood Flow and Metabolism, a leading journal in the field. Price ... "Journal of Cerebral Blood Flow & Metabolism". SAGE Publications Ltd. November 3, 2015. Retrieved June 2, 2020. "People - Price ...
"Mechanically restricted regional blood flow might explain gastrointestinal pain". Nature Clinical Practice Gastroenterology & ...
During the procedure, the person is under regional or general anesthesia. A surgical tourniquet prevents blood flow to the limb ... The person is placed under regional anesthesia and a surgical tourniquet is used. The skin is opened with small curved ... Manual workers Alcoholics People with a higher-than-average fasting blood glucose level People with previous hand injury People ... The treatment can be performed under regional or general anesthesia. The digits are placed under maximal extension tension ...
"Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study". Brain. 120 (7): 1173-1197. doi:10.1093/ ... PET studies seem to indicate that there is a correlation between blood flow in the pontine tegmentum and REM sleep Pontine ...
"Quantitative determination of regional cerebral blood-flow in man". The Lancet. 278 (7206): 806-807. doi:10.1016/s0140-6736(61) ... Certain techniques such as fMRI image tissues (particularly cerebral tissues) by blood flow and thus show metabolism. Also, ... Lassen NA, Ingvar DH, Skinhøj E (October 1978). "Brain Function and Blood Flow". Scientific American. 239 (4): 62-71. Bibcode: ... Some studies require the labeling of a patient's own blood cells with a radionuclide (leukocyte scintigraphy and red blood cell ...
"Quantitative determination of regional cerebral blood-flow in man". The Lancet. 278 (7206): 806-807. doi:10.1016/s0140-6736(61) ... Lassen, Niels A.; Ingvar, David H.; Skinhøj, Erik (October 1978). "Brain Function and Blood Flow". Scientific American. 239 (4 ... as well as the flow rates of streams and rivers. In geology, archaeology, and paleontology, natural radionuclides are used to ...
Fallon BA, Keilp J, Prohovnik I, Heertum RV, Mann JJ (2003). "Regional cerebral blood flow and cognitive deficits in chronic ... and possibly testing for specific antibodies in the blood.[3][11] Blood tests are often negative in the early stages of the ... Regional Disease Vector Ecology Profile: Central Europe. DIANE Publishing. April 2001. p. 136. ISBN 9781428911437. . Archived ... Based on symptoms, tick exposure, blood tests[3]. Prevention. Prevention of tick bites (clothing the limbs, DEET), doxycycline[ ...
"Reduced regional cerebral blood flow in non-psychotic violent offenders". Psychiatry Research: Neuroimaging. 98: 29-41. doi: ... Reduced Cerebral Blood Flow in Angular Gyrus. A couple of studies found reduced cerebral blood flow in angular gyrus of ... 2011). "Mindfulness practice leads to increases in regional brain gray matter density". Psychiatry Research: Neuroimaging. 191 ...
"Regional cerebral blood flow changes in female to male gender identity disorder". Psychiatry and Clinical Neurosciences. 64 (2 ... to compare the regional cerebral blood flow (rCBF) of 11 gynephilic FtM transsexuals with that of 9 androphilic cis females. ... the study did reveal that the gynephilic FtM transsexuals showed significant decrease in blood flow in the left anterior ... of 24 MtF transsexuals not yet treated with cross-sex hormones found that regional gray matter concentrations were more similar ...
Marion, DW; Darby, J; Yonas, H (1991). "Acute regional cerebral blood flow changes caused by severe head injuries". J Neurosurg ...
August 2000). "Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal ... Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time (blood flow) per unit ... extra blood flow in them is used for thermoregulation of a body. In addition to delivering oxygen, blood flow helps to ... Cerebral blood flow determination by rapid-sequence computed-tomography: theoretical analysis. Radiology 137: 679-686, December ...
Methionine enkephalin as a possible neuromodulator of regional cerebral blood flow. Experientia, 41(7), 932-933. https://doi. ...
"The measurement of regional cerebral blood flow during glossolalia: A preliminary SPECT study". Psychiatry Research: ...
... but flowing with hotter blood". Hanrahan spoke highly of his time recording with Jack Bruce, saying "with Jack you are spoilt, ... Burke, Jack (11 August 1984). "The Wax Works". The Lake Geneva Regional News. Lake Geneva, Wisconsin. Retrieved 5 December 2020 ... Music reviewer Jack Burke described Exotica in the Lake Geneva Regional News as "soothing and provocative both, ranging far ...
Devous MD, Trivedi MH, Rush AJ (April 2001). "Regional cerebral blood flow response to oral amphetamine challenge in healthy ... reduced blood flow to the hands and feet), and tachycardia (increased heart rate). Sexual side effects in males may include ... Collaborators (2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of ... The most concerning short-term adverse effects of stimulants, such as elevated blood pressure and heart rate, waned in long- ...
Devous MD, Trivedi MH, Rush AJ (April 2001). "Regional cerebral blood flow response to oral amphetamine challenge in healthy ... reduced blood flow to the hands and feet), and tachycardia (increased heart rate). Sexual side effects in males may include ... following absorption into the blood stream, it is converted by red blood cell-associated enzymes to dextroamphetamine via ... Collaborators (2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of ...
... cerebral blood flow to the cortical area in use must increase proportionally. Along with the increase in flow, hemoglobin ... Hershel Toomim and his wife Marjorie have repeatedly found that NIR HEG training can consciously enhance regional cerebral ... Tinius, T. (2004). New Developments in Blood Flow Hemoencephalography. Hawthorne Press. *^ Toomim, H. (2000). A report of ... PIR has a poorer resolution than NIR and this treatment typically focuses on more global increases in cerebral blood flow.[3] ...
... and poor blood flow in the limbs which may lead to amputations.[1] The sudden onset of hyperosmolar hyperglycemic state may ... "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015 ... Intensive blood sugar lowering (HbA1c,6%) as opposed to standard blood sugar lowering (HbA1c of 7-7.9%) does not appear to ... Blood pressure lowering. Many international guidelines recommend blood pressure treatment targets that are lower than 140/90 ...
A 2015 study of users in the United States also found elevated blood lead levels in 40 percent of those tested. Other concerns ... Chiropractic was developed in the belief that manipulating the spine affects the flow of a supernatural vital energy and ... piercing the body with needles to influence the flow of a supernatural energy) might be believed to increase the effectiveness ... Regional practices. *Chinese herbology. *Indian herbology. *Islamic herbology. *Japanese herbology. *Korean herbology ...
Changing of regional blood flow in various anatomic structures (as a measure of the injected positron emitter) can be ... "J Cereb Blood Flow Metab. 30 (5): 985-93. doi:10.1038/jcbfm.2009.269. PMC 2949183. PMID 20029452.. ... What is actually measured indirectly is the flow of blood to different parts of the brain, which is, in general, believed to be ... Journal of Cerebral Blood Flow and Metabolism. 20 (3): 423-451. doi:10.1097/00004647-200003000-00001. PMID 10724107.. ...
"The simplest, most decisive way that Heydrich could ensure the smooth flow of deportations" to death camps, according to ... and of regional party leaders (the Gauleiter).[123][a] The day after Hitler's speech, on 13 December 1941 Joseph Goebbels wrote ... "the fate of the Jews as a sort of blood bond to tie the civil and military leadership to the Nazi cause".[127] ...
... where the blood remains inside blood vessels. Octopuses have three hearts; a systemic heart that circulates blood round the ... This decreases to 33% when it swims, as more water flows over the gills; skin oxygen uptake also increases. When it is resting ... "Southeastern Regional Taxonomic Centre. Retrieved 27 July 2006.. *^ a b c Mather, Anderson & Wood (2010), pp. 90-97. ... This makes the blood very viscous and it requires considerable pressure to pump it round the body; octopuses' blood pressures ...
... blood flow, or other), and a radionuclide (usually either a gamma-emitter or a positron emitter). There is a degree of overlap ... Tertiary care medical services are provided by specialist hospitals or regional centers equipped with diagnostic and treatment ... After examination for signs and interviewing for symptoms, the doctor may order medical tests (e.g. blood tests), take a biopsy ... "Chairman's Reflections: Traditional Medicine Among Gulf Arabs, Part II: Blood-letting". Heart Views. 5 (2): 74-85 [80]. 2004. ...
Blood vessels enter the central nervous system through the perivascular space above the pia mater. The cells in the blood ... caused by the blockage of the free flow of cerebrospinal fluid.[42] ... "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, ... Most of the brain is separated from the blood by the blood-brain barrier (BBB), which exerts a restrictive control as to which ...
According to social activists, the steroid can cause diabetes, high blood pressure and is highly addictive.[30][31][32] ... Regional Local Production Format State-of-art technology in audiovisual equipment, development, and mass reproduction process. ... Extremely resilient, despite harsh federal laws occasional disruption of the flow of merchandise. Resold in neighboring ... At the regional level criminal convictions of trafficking offenses have increased.[40] ...
Regional differences in mortality rates were influenced by the effects of migration,[217] and of natural disasters.[218] In ... Grain began to flow to buyers in Calcutta after the interprovincial trade barriers were abolished in May 1943,[283] but on 17 ... of blood samples examined at Calcutta hospitals during the peak period, November-December 1944.[207] Statistics for malaria ... It applied to districts readily accessible via the Bay of Bengal and the larger rivers that flow into it.[AB] Implemented on 1 ...
"He was the first of many such people to emerge as strong regional leaders who nurtured the local society in the context of ... The descendants of the Trần clan who came to rule Đại Việt were of mixed-blooded descent due to many intermarriages between the ... In an attempt to stem the refugee flow, avert Vietnamese accusations that Beijing was coercing its citizens to emigrate, and ... he was the head of regional ruling-class society. It was relatively easy for people to shift back and forth between these two ...
Julia Nickson-Soul (class of 1976): actress, Rambo: First Blood Part II, Star Trek: The Next Generation, Babylon 5 and Walker ... "Classroom Without Walls" takes each grade level to a regional destination for several days in the first month of school, and ... and the installation of low-flow faucets, more efficient chillers, and "green walls."[54] The school's one-megawatt solar ... Lynn Collins: actress, John Carter, The Merchant of Venice, X-Men Origins: Wolverine, True Blood[86] ...
"South West Regional Assembly, Draft Regional Spatial Strategy for the South West, paras.1.1.3 and 7.2.1" (PDF). Archived (PDF) ... The first blood was shed at the Wincanton Skirmish in Somerset. In Salisbury, James heard that some of his officers, such as ... who make flow meters; Delphi Diesel Systems UK, on the business park, make electronic unit injectors; Renishaw plc have large ... "South West Regional Assembly, Draft Regional Spatial Strategy for the South West, para.1.1.1" (PDF). Archived (PDF) from the ...
That as the body attempts to compensate for low iron levels by increasing red blood cell production in the young, sieve-like ... Females may be more vulnerable to caries compared to men, due to lower saliva flow than males, the positive correlation of ... Milner, George R. "An Osteological Perspective on Prehistoric Warfare." Regional Approaches to Mortuary Analysis. Ed. Beck, ... Rounick, J.S.; Winterbourn, M.J. (1986). "Stable Isotopes and Carbon Flow in Ecosystems". BioScience. 36 (3): 171-77. doi: ...
Not only must a laminar flow cabinet [laminar flow hood] be used, but the environment in which the hood is located must be ... The hospitals reported affected were Corpus Christi Medical Center Bay Area and Corpus Christi Medical Center Doctors Regional ... a drug used to treat calcium deficiencies and too much potassium in the blood. Implicated in these cases is the Rhodococcus ...
... "with regional grey matter blood flow values being maximally increased in right parietal-occipital regions" during hypnagogic ... T. Balkin, A. Braun, et al., "The process of awakening: A PET study of regional brain activity patterns mediating the ...
In other regional newspapers, the Manchester Evening News wrote that the "Anfield Army charged on to the terrace behind the ... South Yorkshire Police had performed blood alcohol tests on the victims, some of them children, and ran computer checks on the ... and a crush barrier near the access tunnel was removed in 1986 to improve the flow of fans entering and exiting the central ... lung or blood circulation function for some time after being removed from the crush. The report stated that placing fans who ...
They found that as these chills increase, many changes in cerebral blood flow are seen in brain regions such as the amygdala, ... These findings imply that there is no specific regional activation pattern unique to AP. Rather, the availability of specific ... A PET study conducted by Zatorre, Halpern, Perry, Meyer and Evans (1996) investigated cerebral blood flow (CBF) changes related ... used PET to measure changes in cerebral blood flow while participants listened to music that they knew to give them the "chills ...
"The size and regional distribution of the black population". Lewis Mumford Center. Archived from the original on 12 October ... As a result, some of the European descended population also has West African or Amerindian blood. According to the last census ... "Sex-biased gene flow in African Americans but not in American Caucasians", GMR, 2007, Vol. 12, No. 6. ... The official policy became one of biological and cultural assimilation: "Eliminate the full-blood and permit the white ...
According to the authors, the admixture was likely due to a "gene flow from a European-related gene pool" during the Bronze to ... The Canaanites, Amorites, Jebusites, and the rest, are so closely bound together by the theory of blood-kinship which even yet ... What holds true for the pottery of Philistia also holds true for other aspects of the regional material culture. Whereas Aegean ...
Blood test[edit]. In conjunction, measuring blood glucose level every 10 to 15 minutes after ingestion will show a "flat curve ... The unabsorbed sugars and fermentation products also raise the osmotic pressure of the colon, causing an increased flow of ... A 2016 study of over 60,000 participants from 89 countries found regional prevalence of lactose malabsorption was "64% (54-74) ... Blood is then drawn again at the 30-minute, 1-hour, 2-hour, and 3-hour marks. If the lactose cannot be digested, blood glucose ...
... blood is "stolen" from the circle of Willis to preserve blood flow to the upper limb. Subclavian steal syndrome results from a ... "Spect measurements of regional cerebral perfusion and carbon dioxide reactivity: Correlation with cerebral collaterals in ... blood flow from the other blood vessels can often preserve the cerebral perfusion well enough to avoid the symptoms of ischemia ... Blood flows up to the brain through the vertebral arteries and through the internal carotid arteries. ...
The wait time and isolation of blood flow from the region is important for avoiding an overdose of the anesthetic agent in the ... It is important that the region is isolated from active blood flow at this time. Analgesic effect typically remains for up to ... Intravenous regional anesthesia. Intravenous regional anesthesia (IVRA) using older tourniquet equipment. Modern electronic ... where there is a risk of massive hemolysis due to low oxygen tension or hemolytic crisis due to restricted blood flow).[1][4][7 ...
"Morbidity & Mortality: 2009 Chart Book on Cardiovascular, Lung, and Blood Diseases" (PDF). National Heart, Lung, and Blood ... The greatest reduction in air flow occurs when breathing out, as the pressure in the chest is compressing the airways at this ... "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the ... A chest X-ray and complete blood count may be useful to exclude other conditions at the time of diagnosis.[80] Characteristic ...
When the Kainai (Blood) Nation refused to accept the sale of their lands in 1916 and 1917, the Department of Indian Affairs ... Indigenous art traditions are organized by art historians according to cultural, linguistic or regional groups: Northwest Coast ... grass grows and rivers flow".. ...
WHO Regional Office Europe. ISBN 9789241595261. .. *^ a b Kraft, M; Spahn, T W; Menzel, J; Senninger, N; Dietl, K.-H; Herbst, H ... At the beginning conversation comes in a gentle, easy flow and hearing and sight are honed, becoming able to perceive subtle ... Recent usage of kava has been documented in forensic investigations by quantitation of kavain in blood specimens. The principal ...
1995). "Benzodiazepine receptors mediate regional blood flow changes in the living human brain". 》Proc. Natl. Acad. Sci. U.S.A ...
... white blood cells (leukocytes), or leukocyte esterase.[42] Another test, urine microscopy, looks for the presence of red blood ... where urine flows back up the ureters and towards the kidneys. While pregnant women do not have an increased risk of ... "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, ... However, infection may also occur via the blood or lymph.[6] It is believed that the bacteria are usually transmitted to the ...
Regional groupsEdit. Main article: List of Indigenous Australian group names. The broad term Aboriginal Australians includes ... Over time Australia has used various means to determine membership of ethnic groups such as lineage, blood quantum, birth and ... A 2012 paper reports that there is also evidence of a substantial genetic flow from India to northern Australia estimated at ... However, in 1889 Parliament recognised Fanny Cochrane Smith (d:1905) as the last surviving full-blooded Tasmanian Aborigine.[g] ...
Fetal blood pressure and heart rate, blood gases, acid base status, electrocorticogram, electromyogram and regional blood flow ... Regional blood flow in asphyxiated fetuses with seizures.. Ball RH1, Espinoza MI, Parer JT, Alon E, Vertommen J, Johnson J. ... Our purpose was to determine ovine fetal regional blood flow changes during asphyxia of such severity that it results in ... Blood flow increased to the heart and adrenals during asphyxia and decreased to spleen, gut, kidneys, and carcass (p , 0.05). ...
BF was measured with radioactive microspheres injected into the left ventricle; blood pressure (BP) and arterial blood samples ... We studied the blood flow (BF) to and vascular resistance (VR) of vital tissues in 7 anesthetized newborn lambs in response to ... REGIONAL DISTRIBUTION OF BLOOD FLOW WITH HYPOVOLEMIC HYPOTENSION IN THE NEONATAL LAMB. *J Timothy ONeill1. , ... ONeill, J., Golden, S. & Alden, E. REGIONAL DISTRIBUTION OF BLOOD FLOW WITH HYPOVOLEMIC HYPOTENSION IN THE NEONATAL LAMB. ...
... Good Day Kansas Posted: Oct 28, 2019 / 02:51 PM CDT. / Updated: ...
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1975) Regional Differences in β-Adrenergic Effects on Local Cerebral Blood Flow and Adrenergic Innervation. In: Langfitt T.W., ... Regional Differences in β-Adrenergic Effects on Local Cerebral Blood Flow and Adrenergic Innervation. ... "Continuous measurement of local cerebral blood flow, PaO2, PaCO2, and blood pressure in the nonanesthetized animal." Pflügers ... Tyramine-induced contraction of the isolated middle cerebral artery of the cat." In Brain and Blood Flow, R. W. Ross Russell, ...
J Cereb Blood Flow Metab. 2009 Jan;29(1):197-205. doi: 10.1038/jcbfm.2008.112. Epub 2008 Oct 1. Research Support, N.I.H., ... Global hemispheric and regional cerebral blood flow (CBF) at baseline and after return of spontaneous circulation (ROSC). Time ... Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats.. Manole ... Magnetic Resonance Imaging Assessment of Regional Cerebral Blood Flow after Asphyxial Cardiac Arrest in Immature Rats ...
Cerebral Blood Flow Cerebral Blood Volume Cerebral Vasospasm Regional Cerebral Blood Flow Near Infrared Spectroscopy These ... Non invasive measurement of regional cerebral blood flow and regional cerebral blood volume by near infrared spectroscopy and ... Noninvasive measurement of regional cerebral blood flow by near-infrared spectroscopy and indocyanine green. J Cereb Blood Flow ... regional cerebral blood volume (rCBV), regional mean transit time (rMTT), and regional cerebrovascular resistance (rCVR) in ...
To investigate the effect of EA on regional cerebral blood flow, cognitive deficits, inflammation, and its probable mechanisms ... Electroacupuncture Improves Cognitive Deficits through Increasing Regional Cerebral Blood Flow and Alleviating Inflammation in ... using laser Doppler flowmetry to test changes of regional cerebral blood flow (rCBF); double antibody sandwich enzyme-linked ...
Gordon, C., Emans, S., Grace, E. et al. Regional Cerebral Blood Flow Differences During High-Caloric Food Challenge in Patients ... Regional Cerebral Blood Flow Differences During High-Caloric Food Challenge in Patients with Anorexia Nervosa Versus Normal ... was used to make positron emission tomographic measurements of regional cerebral blood flow (rCBF). We compared 8 young women ...
Distribution of regional cerebral blood flow in voluntarily diving rats. Message Subject (Your Name) has sent you a message ... The distribution of regional cerebral blood flow (rCBF) was examined in conscious, voluntarily diving rats using the brain ... A detailed examination of the regional distribution of cerebral blood flow revealed that almost all brain regions were ... Because some brain regions did not increase flow significantly during diving, these results suggest that not all brain regions ...
... and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. Therefore ... and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. Therefore ... Whole blood viscosity and hematocrit as well as ... ... with changes in bioenergetic and regional cerebral blood flow ( ... we determined the pattern of regional cerebral perfusion mania patients and using patients with major depressive disorder (MDD ...
However, the effect on regional cerebral blood flow (CBF) is unknown. In this study, we measured regional CBF (rCBF) in ... However, the effect on regional cerebral blood flow (CBF) is unknown. In this study, we measured regional CBF (rCBF) in ... Regional cerebral blood flow during hyperventilation in patients with acute bacterial meningitis Clin Physiol. 2000 Sep;20(5): ... Regional cerebral blood flow abnormalities are frequent in patients with acute bacterial meningitis. Short-term ...
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. ST Grafton, JC Mazziotta ... Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET ... Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET ... Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET ...
A method of measuring regional blood flow (RBF) that is simple in procedure and calculations is described. By arresting flow ... with that delivered by the blood. If the arterial pulse is characterized by its mean concentration (Ca) over a known duration ( ...
... Reza Nemati ... S. E. Mouridsen, C. Videboek, H. Sogaard, and A. R. Andersen, "Regional cerebral blood-flow measured by HMPAO and SPECT in a 5- ... L. A. OTuama, D. K. Urion, M. J. Janicek, S. T. Treves, B. Bjornson, and J. M. Moriarty, "Regional cerebral perfusion in ...
First-Pass Measurements of Regional Blood Flow with External Detectors Message Subject (Your Name) has sent you a message from ... First-Pass Measurements of Regional Blood Flow with External Detectors. Nizar A. Mullani and K. Lance Gould ... A quantitative index of regional blood flow in canine myocardium derived noninvasively with N-13 ammonia and dynamic positron ... Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured ...
Dynamics and Control Mechanisms in Maintenance of Regional Cerebral Blood Flow. YURI E. MOSKALENKO, IVAN T. DEMCHENKO, ... Dynamics and Control Mechanisms in Maintenance of Regional Cerebral Blood Flow. YURI E. MOSKALENKO, IVAN T. DEMCHENKO, ... Dynamics and Control Mechanisms in Maintenance of Regional Cerebral Blood Flow. YURI E. MOSKALENKO, IVAN T. DEMCHENKO, ... are followed by an increase of local blood flow (LCBF) in regional brain cortex up to 0.3 to 0.4 ml per minute per 1 gm brain ...
... a high-blood flow, low-arterial resistance group with normal to decreased Pv, now denoted "high-flow" POTS; 2) a low-blood flow ... Regional blood volume and peripheral blood flow in postural tachycardia syndrome Message Subject (Your Name) has sent you a ... Regional blood volume and peripheral blood flow in postural tachycardia syndrome. Julian M. Stewart, Leslie D. Montgomery ... Regional sequestration of blood occurs in normal-flow and high-flow variants, whereas a degree of absolute hypovolemia and ...
The decrease in blood flow to the superior regions of the lung coupled with the finding of no change or decreases in flow to ... these values were assumed to be proportional to the respective blood flows which were present below each site at the respective ... the dependent regions of the lung suggests that selective increases in resistance to blood flow to the dependent, presumably ... 3-dimensional and contour map displays of the scintiscan and related physiologic data indicate that pulmonary blood flow tended ...
Regional cerebral blood flow, as measured by dASL. [ Time Frame: 1 week, 6 and 12 months ]. Part I: regional cerebral blood ... Part II: regional cerebral blood flow, measured at 6 months and 12 months in AD participants and normal control participants. ... The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be ... A Study to Assess Regional Cerebral Blood Flow as an Alzheimers Disease Biomarker Compared to Positron Emission Tomography in ...
We examined the possible relationship between the rate of cognitive deterioration and regional cerebral blood flow (rCBF) ... The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimers disease: a longitudinal ...
Regional and overall inequality of ventilation and blood flow in patients with chronic airflow obstruction ... Regional and overall inequality of ventilation and blood flow in patients with chronic airflow obstruction ... The distribution of blood flow was found to range between a normal gradient and the reverse of normal. Differences between left ... Acetylcholine altered the blood flow distribution pattern in three out of nine subjects and this may represent vasodilatation ...
Effects of ET-1 and MgSO4 on regional and subregional blood flows. Effects on cranial flow (brain, eye, tongue, cranial skin). ... MgSO4 had no effect on blood flow through the eyes or cranial skin, but increased brain and tongue blood flows to above ... MALIK, A.B., KAPLAN, J.E. & SABA, T.M. (1976). Reference sample method for cardiac output and regional blood flow determination ... CHI, O.Z., POLLACK, P. & WEISS, H.R. (1990). Effects of magnesium sulphate and nifedipine on regional cerebral blood flow ...
Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow. Makio Kaminogo, Akio Ichikura ... Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow ... Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow ... Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow ...
This study was designed to examine the relationship between epicardial ST change (EpST) and regional myocardial blood flow ( ... Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in ... Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in ... Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in ...
... ... "Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex," Journal of ... and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may ... "Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex," J. Biomed. ...
This true zero blood flow reading was compared to the zero blood flow measurement of the flowmeter to ensure the validity of ... Key words: ultrasonic transit-time, iliac blood flow, renal blood flow, exercise, anesthesia, conscious rats ... of zero blood flow obtained by the zero flow baseline function of the flowmeter and by measurement of zero blood flow after ... blood volume flow from two identical measurements resulting in a zero flow output regardless of the actual blood flow in the ...
Measurements of regional cerebral blood flow (rCBF), analysis ofcerebrospinal fluid, auditory brain stem responses (ABR) ... Measurements of regional cerebral blood flow (rCBF), analysis of. cerebrospinal fluid, auditory brain stem responses (ABR) and ... Cerebral dysfunction in fibromyalgia (FM): evidence from regional cerebral blood flow measurements, otoneurological tests & ... normal flow level with slight but significant focal flow. decreases in dorsolateral frontal cortical areas of both. hemispheres ...
  • The tracer, oxygen 15-labeled carbon dioxide, was used to make positron emission tomographic measurements of regional cerebral blood flow (rCBF). (
  • The distribution of regional cerebral blood flow (rCBF) was examined in conscious, voluntarily diving rats using the brain blood flow tracer N-[14C]isopropyl-p-iodoamphetamine and quantitative autoradiography. (
  • While evidence that episodes of mania in bipolar I are associated with changes in bioenergetic and regional cerebral blood flow (rCBF) and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. (
  • In this study, we measured regional CBF (rCBF) in patients with acute bacterial meningitis before and during short-term hyperventilation. (
  • Using standard templates to identify regions of interest (ROIs), we calculated rCBF in percentage of cerebellar (99mTc-HMPAO images) or mean hemispheric (133Xe images) flow for each ROI, the degree of side-to-side asymmetry for each ROI, and the anterior-to-posterior flow ratio. (
  • On 99mTc-HMPAO images (n=12), relative rCBF and the anterior-to-posterior flow ratio were significantly lower in patients than in controls in the frontal and parietal cortex as well as in the basal ganglia. (
  • We examined the possible relationship between the rate of cognitive deterioration and regional cerebral blood flow (rCBF) patterns in patients with AD. (
  • Background and Purpose To verify whether the monitoring of regional cerebral oxygen saturation (rSO 2 ) with transcranial near-infrared spectroscopy would successfully reflect changes in intracranial hemodynamics but not changes in extracranial compartment, we measured rSO 2 and regional cerebral blood flow (rCBF) simultaneously in seven patients with cerebral ischemia and five normal volunteers before and after acetazolamide administration. (
  • 45% men) with prehypertensive BP underwent neuropsychological testing and assessment of regional cerebral blood flow (rCBF) response to cognitive challenges. (
  • Measurements of regional cerebral blood flow (rCBF), analysis of cerebrospinal fluid, auditory brain stem responses (ABR) and oculomotor tests were performed in 19 patients with fibromyalgia. (
  • The results from the rCBF measurements showed a normal flow level with slight but significant focal flow decreases in dorsolateral frontal cortical areas of both hemispheres. (
  • In recent years in vivo imaging techniques, principally single photon emission computed tomography (SPECT), have been used to study regional cerebral blood flow (rCBF) in patients with focal epilepsy. (
  • To address this issue, we explicitly examined the effects of circadian and homeostatic regulation on functional connectivity (FC) and regional cerebral blood flow (rCBF) in healthy human volunteers, using whole-brain resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labeling (ASL). (
  • However, because of the pharmacokinetic properties of cocaine, brief duration of action and complex behavioral actions, regional cerebral blood flow (rCBF), a rapid marker of neuronal activity, was used to identify structures involved in different temporal aspects of its pharmacologic profile. (
  • Summary: Perfusion CT studies of regional cerebral blood flow (rCBF), involving sequential acquisition of cerebral CT sections during IV contrast material administration, have classically been reported to be achieved at 120 kVp. (
  • Perfusion CT performed for the evaluation of regional cerebral blood flow (rCBF) involves sequential acquisition of cerebral CT sections obtained in axial mode during IV administration of iodinated contrast material. (
  • Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. (
  • At baseline the two groups showed an identical rCBF and mean hemispheric blood flow. (
  • article{a42a0f99-94fd-4913-b3c1-936a0a2ea31b, abstract = {Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. (
  • The aim of this study was to investigate the differences in regional cerebral blood flow (rCBF) between two groups of subjects exposed to different types of traumatic stressor either developing or not PTSD. (
  • To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. (
  • Although the core of the diagnostic process in dementia rests firmly on clinical and cognitive assessments, a wide range of investigations are available to aid diagnosis.Regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) is an established clinical tool that uses an intravenously injected radiolabelled tracer to map blood flow in the brain. (
  • This pattern of blood flow is different to patterns seen in other subtypes of dementia and so can be used to differentiate FTD.It has been proposed that a diagnosis of FTD, (particularly early stage), should be made not only on the basis of clinical criteria but using a combination of other diagnostic findings, including rCBF SPECT. (
  • The influence of such therapy on regional cerebral blood flow (rCBF) remains, however, unknown. (
  • This thesis utilized radioisotope-labeled tracers to investigate the distribution of cardiac output and regional cerebral blood flow (rCBF) during a mammalian diving response. (
  • The present study addressed the question of hemispheric asymmetry of frontal regions and aimed to further understand the acute effects of high- and low-frequency rTMS on regional cerebral blood flow (rCBF). (
  • Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. (
  • To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO 2 ) were compared in selected human subjects. (
  • The authors examined the possible correlation between the rCBF values obtained by PET and the blood flow speed readings measured by TCD in MCAs. (
  • We measured the regional cerebral blood flow (rCBF) using the Xenon inhalation method in 31 treatment-refractory patients with OCD and the same number of age-matched normal controls. (
  • Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. (
  • The regional cerebral blood flow (rCBF) measure has been proposed as a biomarker for HIV-associated CNS damage. (
  • To identify associated changes in the functional brain response, we studied performance measures and regional cerebral blood flow (rCBF) using positron emission tomography (PET) in healthy subjects during performance of a WM task. (
  • blood pressure (BP) and arterial blood samples were taken from axillary arteries. (
  • We characterized regional and temporal changes in CBF from 5 to 150 mins after asphyxial CA of increasing duration (8.5, 9, 12 min) in postnatal day (PND) 17 rats using the noninvasive method of arterial spin-labeled magnetic resonance imaging (ASL-MRI). (
  • We also assessed blood-brain barrier (BBB) permeability, and evaluated the relationship between CBF and mean arterial pressure after resuscitation. (
  • Relationship between mean arterial pressure (MAP) and cerebral blood flow (CBF). (
  • In cases of distal arterial narrowing, techniques measuring regional values of local cortical perfusion, representing se-lected vascular territories, may be more sensitive. (
  • Computer-generated 3-dimensional and contour map displays of the scintiscan and related physiologic data indicate that pulmonary blood flow tended to redistribute toward the midthoracic region during acceleration exposures concomitantly with large decreases in arterial oxygen saturation presumably from pulmonary shunting via the dependent regions of the lung. (
  • The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimer's disease. (
  • Since the intracranial microvasculature consists of approximately 75% venous, 20% arterial, and 5% capillary blood, 6 7 the oximeter reading is weighted toward venous blood oxygen saturation, representing oxygen extraction by the cerebral tissue. (
  • This study was performed to determine whether stimulation of the carotid chemoreceptors increases total or regional cerebral blood flow and whether activation of arterial chemoreceptors contributes to cerebral vasodilation during systemic hypoxemia. (
  • Resting arterial inflow and reactive hyperemic blood flow (RHBF) were assessed with venous occlusion plethysmography. (
  • Nine open-chest, anesthetized pigs were instrumented to monitor regional coronary blood flow and segment shortening, left ventricular dP/dt, heart rate, and pulmonary artery and aortic blood pressures and to sample arterial and regional coronary venous blood for oxygen content and complete blood counts. (
  • The primary outcome measure is changes in regional cerebral blood flow from baseline in the arterial territories of the anterior cerebral artery, medial cerebral artery and the posterior cerebral artery, measured by CT perfusion scan. (
  • Increase in regional cerebral blood flow following experimental arterial air embolism. (
  • Measurement of the total flow rate is performed by intravenous infusion of a test substance that is eliminated only by the liver, measurements of steady-state arterial and liver venous concentration differences across the organ and calculation by Fick's principle. (
  • Steady-state clearance measurements can be used to measure the total hepatic flow rate for substances with a liver vein concentration that is negligible when compared to the arterial concentration. (
  • Increasing mean arterial pressure by 20 mm Hg further increased cardiac output and oxygen delivery but without improving portal vein, renal artery, and jejunal mucosal blood flows. (
  • Conclusions: Norepinephrine, administered to increase mean arterial pressure by 10 mm Hg in an acute model of volume-resuscitated endotoxic shock, improved systemic and regional perfusion. (
  • The administration of norepinephrine to increase mean arterial pressure 20 mm Hg above shock did not increase renal and splanchnic blood flows, despite an enhanced cardiac output. (
  • During CPB, the mean arterial pressure (MAP) and pump flow rates were 40 mm Hg and 150 ml/kg per min, respectively. (
  • Arterial pressure and blood flow were used to calculate vascular resistance. (
  • Arterial spin labeling (ASL) MRI is a novel noninvasive technique that can measure regional CBF. (
  • Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in awake dogs. (
  • This study was designed to examine the relationship between epicardial ST change (EpST) and regional myocardial blood flow (RMBF) following coronary occlusion and extent of myocardial infarction (MI) in awake dogs. (
  • Improved regional myocardial blood flow, left ventricular unloading, and infarct salvage using an axial-flow, transvalvular left ventricular assist device. (
  • METHODS AND RESULTS Eighteen dogs were instrumented with regional myocardial function sonomicrometers in the ischemic and control zones. (
  • Regional myocardial blood flow was determined by using 15-microns radioactive microspheres. (
  • Absolute regional myocardial blood flow in the ischemic zone increased slightly (p = 0.002) in the Hemopump animals and did not change in the balloon pump animals. (
  • C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism. (
  • Intracoronary infusion of human or porcine C5a in doses ranging from 10 to 500 ng produced a significant reduction in regional coronary blood flow and myocardial function. (
  • The effect of bolus intravenous injections of amrinone (1-2 mg/kg) on abdominal organ, central nervous system, and myocardial blood flow distribution was examined in 15 anesthetized dogs. (
  • White, J. G. / Acute effects of amrinone on regional myocardial and systemic blood flow distribution in the dog . (
  • Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. (
  • After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. (
  • Pulsatile flow generates significantly higher energy, enhancing myocardial flow during and after hypothermic CPB and after 60 minutes of ischemia in this model. (
  • Myocardial blood flow (MBF) estimation with 82 Rubidium ( 82 Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. (
  • The radioactive microsphere method for the assessment of regional myocardial blood flow after coronary artery occlusion. (
  • Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. (
  • To investigate the effect of EA on regional cerebral blood flow, cognitive deficits, inflammation, and its probable mechanisms in chronic cerebral ischemia (CCI) rats. (
  • Distribution of regional cerebral blood flow in voluntarily diving rats. (
  • Previously, we demonstrated that i.v. infusion of magnesium sulphate (MgSO 4 ) alone, or in the presence of vasoconstrictors, caused increases in flow and conductance in the common carotid, internal carotid and hindquarters vascular beds, in conscious rats. (
  • The objective of the present study was to validate the transit-time technique for long-term measurements of iliac and renal blood flow in rats. (
  • The measurements were stable over an experimental period of one week but were affected by probe size (resting flows were underestimated by 57% with a 2-mm probe when compared with a 1-mm probe) and by anesthesia (in the same rats, iliac flow was reduced by 50-60% when compared to the conscious state). (
  • All previous studies concerning regional blood flow changes induced by exercise in rats (18-21) were conducted using the microsphere technique, which only provides information about static but not dynamic flow behavior. (
  • Kallikrein gene transfer induces angiogenesis and further improves regional cerebral blood flow in the early period after cerebral ischemia/reperfusion in rats. (
  • The goal of the current study is to quantitate in rats the time course of cardiac output and regional blood flows after thiopental administration. (
  • The effects of thiopental on regional blood flows were determined in chronically instrumented rats using a radioactive microsphere technique. (
  • The regional spinal cord blood flow at the C5-6 level was lower than the spinal cord blood flow at C3-4 level in chronically spinal-cord-compressed rat, were as the difference was not observed in rats without spinal cord compression. (
  • The comparison of the regional spinal card blood flow at C5-6 level between chronically spinal-cord-compressed rats and no compression rats did not show statistically significant difference. (
  • The ratio of regional spinal read blood flow at the C5-6 level to C3-4 level was determined for each rat There was a statistically significant difference at the 5 %level between the spinal-cord-compressed rats and non-compressed rats in the ratio of spinal blood flow C3-4 to C5-6. (
  • The pattern of blood flow within the brain was also investigated during voluntarily initiated diving in rats. (
  • It is concluded that an oxygen conserving response, involving a redistribution of blood flow toward the brain, occurs during voluntarily initiated diving in rats. (
  • Ocular and regional cerebral blood flow in aging Fischer-344 rats. (
  • These data suggest that regional cerebral and spinal blood flow and vascular resistance remain largely unchanged in conscious aged rats at rest but that elevations in ocular vascular resistance and, correspondingly, decreases in ocular perfusion with advanced age could have serious adverse effects on visual function. (
  • The absolute regional blood flow to various organs and regional cerebral blood flow were expressed in terms of milliliters per minute per gram tissue weight, and the values mostly agreed with those reported previously in rats. (
  • We hypothesized that nitric oxide (NO) opposes regional vasoconstriction caused by acute angiotensin II (ANG II) infusion in conscious rats. (
  • abstract = "Purpose of Review: To provide a brief overview of the main techniques to measure muscle blood flow in humans and highlight some of the strengths and weaknesses associated with each technique. (
  • The limitations of the available techniques encourage the development of a practical method for measuring regional cerebral perfusion non invasively in different vascular territories. (
  • Therefore, we determined the pattern of regional cerebral perfusion mania patients and using patients with major depressive disorder (MDD) as positive controls and healthy participants as negative controls. (
  • have observed that the brain advanced function is related to the changes in the cerebral blood flow perfusion, and that both cerebral blood flow and blood flow velocity in certain regions will change when human emotion is changed ( 4 ). (
  • These results provide baseline values for regional blood flow during CPR which can be used to evaluate alternative CPR techniques and/or drugs which may improve perfusion of vital organs during CPR. (
  • Single-photon emission tomography (SPET) was used to measure regional brain perfusion using technetium-99m labelled ethyl cysteinate dimer (ECD). (
  • No significant alterations were found in regional cortical perfusion, indicating that the increased binding index was not a consequence of increased tracer delivery. (
  • MR measures of renal perfusion, oxygen bioavailability and total renal blood flow in a porcine model: noninvasive regional assessment of renal function. (
  • This study aims to evaluate changes in regional metabolism and cerebral perfusion in subjects who used methamphetamine (METH) prior to sustaining a TBI. (
  • intestinal, gastric mucosal, gallbladder, and triceps flows were reduced by values ranging from 26.7 to 38.9% and central nervous system perfusion was reduced by values ranging from 11.8 to 19.4% in all regions except the caudate nucleus. (
  • This chapter provides an overview of methods for the measurement of hepatic blood flow for the whole liver and hepatic blood perfusion per unit volume of liver tissue. (
  • Hepatic blood perfusion can be measured by dynamic PET using tracers for which the permeability of the plasma-hepatocyte membrane is high. (
  • Quantification of the hepatic blood perfusion requires measurements of the supply of tracer from an artery and the inaccessible portal vein, but methods have been developed that replace the invasive portal venous samples using tissue-derived information or a portal venous model. (
  • Two indexes of cerebral perfusion, a ratio of regional flow compared with occipital flow and a left-right asymmetry index, demonstrated relative left frontal hypoperfusion in presenile- but not senile-onset patients and did not appear to be an artifact of the severity differences. (
  • Local skin blood flow (LSBF) using the Walker's deep burn rat model was studied on the first three postburn days using the carbon-14 iodoantipyrine ([ 14 C]IAP) perfusion method. (
  • Frackowiak RS, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: theory, procedure, and normal values. (
  • This paper investigates the relationship between the blood oxygenation level dependent (BOLD) contrast effect and regional cerebral blood flow using the techniques of functional MRI (fMRI) and positron emission tomography (PET). (
  • No effects of short-term GSM mobile phone radiation on cerebral blood flow measured using positron emission tomography. (
  • Newer imaging techniques (MRI, positron emission tomography, and contrast-enhanced ultrasonography) promise increased resolution of measurements of local blood flow, including in discrete tissues in which more classical techniques are not able to be used. (
  • J Cereb Blood Flow Metab. (
  • Recently, short-term visual deprivation has been shown to affect a variety of non-visual processes and regional cortical activity (Sathian & Zangaladze, 2001). (
  • To keep up with the nutritional and waste removal demands of a higher metabolic rate, cerebral blood flow to the cortical area in use must increase proportionally. (
  • Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected by cerebral blood flow in the activated cortical tissue and send the data to a computer, which then calculates the ratio of red to infrared light and translates it into a visual signal of corresponding to oxygenation level on a graphical interface the patient can see. (
  • There is increasing interest in the continuous measurement of total and regional blood flow in conscious animals. (
  • Comparison of xenon-enhanced CT with ultrafast CT for measurement of regional cerebral blood flow. (
  • Measurement of regional cerebral blood flow using ultrafast computed tomography. (
  • Measurement of testicular artery blood flow is used in several species to evaluate reproductive function and testicular and scrotal pathology. (
  • With his colleague Ole Munck he began in the 1950s to use radioactive isotopes for the measurement of the blood circulation in the brain, and in the beginning of the 1960s he together with David H. Ingvar [sv] from University of Lund began the development of methods for regional measurements on the brain with krypton-85 and xenon-133 isotopes. (
  • We studied the blood flow (BF) to and vascular resistance (VR) of vital tissues in 7 anesthetized newborn lambs in response to hypovolemic hypotension. (
  • Of particular interest was the finding that MgSO 4 caused increases in flow in the cerebral and coronary vascular beds. (
  • Whether band flossing influences regional vascular adaptations or strength has not been evaluated. (
  • The purpose of this study was to test the hypothesis that old age results in an increase in vascular resistance and, correspondingly, a decrease in blood flow to ocular, regional cerebral, and spinal tissue in the rat. (
  • Fetal blood pressure and heart rate, blood gases, acid base status, electrocorticogram, electromyogram and regional blood flow (radioactive microspheres) measurements were recorded. (
  • The effect of changes in the direction and magnitude of the gravitational-inertial force environment on the regional distribution of impacted 35-micron diameter microspheres has been measured in the lungs of six anesthetized chimpanzees. (
  • Regional blood flow and cardiac output were measured using radioactively labelled polystyrene microspheres of 15 ±3P diameter, injected into the left ventricle. (
  • To measure total and regional cerebral blood flow, we used labeled 15-mu microspheres. (
  • Regional flows were measured with radiolabeled microspheres. (
  • Peripheral blood flow was measured in the supine position by venous occlusion strain-gauge plethysmography of the forearm and calf to subgroup patients. (
  • It was found that blood flow during CPR is highly dependent on venous valving and aortic valve competence. (
  • Although invasive techniques have provided valuable insight into tissue blood flow, noninvasive techniques such as venous occlusion plethysmography and Doppler ultrasound are frequently used and provide accurate measurements of blood flow. (
  • BBB was impermeable to gadoteridol 150 mins after CA. CBF in the 12-min CA group was blood pressure passive at 60 min assessed via infusion of epinephrine. (
  • In addition, the arteriovenous difference of white blood cells was increased significantly after anaphylatoxin infusion, indicating intravascular trapping in the myocardium. (
  • 0.05) during lipid than during glycerol infusion, whereas regional blood flow remained unchanged. (
  • The regional CBF was examined utilizing 99m Tc-HMPAO SPECT after sodium lactate infusion (0.5 M, 5 mL/kg body weight) and 0.9% NaCl infusion, one on each of two separate days. (
  • The purpose of this study was to investigate metabolism and blood flow locally in full-thickness wounds healing with (limb wounds) and without (body wounds) formation of EGT. (
  • Ten patients with a presenile (before 65 years old) onset of the disease and 16 with senile onset of the disease were evaluated clinically and neuropsychologically and studied with single photon emission computed tomography using the blood flow tracer [ 123 I] N -isopropyl-p-iodoamphetamine. (
  • Single Photon Emission Computerised Tomography (SPECT) was carried out to measure regional cerebral blood flow in DAT patients and controls. (
  • 1975) Regional Differences in β -Adrenergic Effects on Local Cerebral Blood Flow and Adrenergic Innervation. (
  • There is evidence showing increased resting energy expenditure in manic episode patients, suggesting an altered regulation of energy and local cerebral blood flow in mania ( 3 ). (
  • CARDIAC output and regional blood flows transport thiopental to the central nervous system and distribute it to body tissues. (
  • The purpose of this study was to show that the Hemopump transvalvular axial-flow left ventricular assist device provides superior left ventricular unloading, ischemic zone collateral blood flow, and infarct size reduction compared with intra-aortic balloon counterpulsation and reperfusion alone. (
  • During normothermic CPB, left ventricular flow was higher in the PP than the NPP group (202 ± 25 vs. 122 ± 20 ml/100 g per min). (
  • 0.05), left ventricular flow was higher in the PP group. (
  • Right ventricular flow resembled left ventricular flow. (
  • Whole left ventricular (LV) 82 Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. (
  • Discrepancies between radiographic findings and delayed ischemic deficits may depend on the relationship between local cerebral oxygen-requirement and -deliv-ery, which only can be determined if cerebral blood flow (CBF) and cerebral oxy-gen extraction can be estimated. (
  • A decrease in the jugular bulb oxygen saturation (SjvO 2 ) may be useful only in detecting severe prox-imal cerebral vasospasm, leading to significant reduction of hemispheric blood flow. (
  • The resting state fMRI BOLD (blood-oxygen-level-dependent) signal will be evaluated for 'Goodness-of-Fit' to the default mode network at Baseline, 1 week, and 6 and 12 months in AD participants and normal control participants. (
  • Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. (
  • Regional cerebral oxygen supply and utilization in dementia. (
  • Changing dopaminergic activity through different pathways : consequences for renal sodium excretion, regional blood flow and oxygen tension in the rat. (
  • A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. (
  • Along with the increase in flow, hemoglobin molecules in the blood, which are responsible for the transport and transference of oxygen to tissue throughout the body, must increase the amount of oxygen they deliver to the activated region of the cortex, resulting in a greater local blood oxygenation level. (
  • In the rat, renal (14), mesenteric and aortic flows (15) were measured with Transonic probes and compared with known blood/saline flows obtained from pump-perfused circuits (15) or by clearance of p-aminohippuric acid (14). (
  • We tested the null hypothesis that hemodynamics and regional blood flows do not change over time after intravenous bolus administration of thiopental. (
  • IMSEAR at SEARO: Alteration in systemic hemodynamics & regional brain blood flow by isoprenaline. (
  • [2-4] Acute blood flow versus time responses to thiopental are reported for individual organs, [5,6] but not for all organs simultaneously and not for the tissues of distribution. (
  • In future analyses, blood flow data will be used to develop a physiologically based pharmacokinetic model describing thiopental uptake into multiple organs and tissues. (
  • Regional cerebral blood flow measured tomographically by 133Xenon inhalation circumvents the extra-cranial contamination and the superposition of intracranial tissues that hamper 133Xenon inhalation flow studies using stationary detectors. (
  • Cardiac output and blood flows to most tissues were determined by radioactive microsphere distribution. (
  • Global hemispheric and regional cerebral blood flow (CBF) at baseline and after return of spontaneous circulation (ROSC). (
  • The significance of this finding is that this point to the possibility of the systemic conditions that may affect spinal and circulation affecting the outcome of spondylotic myelopathy, and there may be pharmacological treatment for the illness by improvement of spinal cord blood flow. (
  • Regional blood flow with first circulation time-indicator curves: a simplified, physiologic method of interpretation. (
  • Assessment of intermittent UMTS electromagnetic field effects on blood circulation in the human auditory region using a near-infrared system. (
  • Assessment of potential short-term effects of intermittent UMTS electromagnetic fields on blood circulation in an exploratory study, using near-infrared imaging. (
  • By arresting flow promptly after a short pulse of diffusible tracer, it is feasible to equate the tracer retained in the tissue (Cif) with that delivered by the blood. (
  • Until the development of the blood flow tracer HMPAO (hexamethylpropyleneamine oxime) there was no practical way to study regional cerebral blood flow during or soon after seizures. (
  • In vivo neuroimaging studies can assist in understanding the neural regions involved in energy dysfunction in bipolar disorder via analyzing blood flow and metabolic processes. (
  • During the chronic stage of Complex Regional Pain Syndrome (CRPS), impaired microcirculation is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. (
  • Lactate is a metabolic vasodilator and is known to provoke increased cerebral blood flow (CBF) in healthy adults. (
  • Casey, DP , Curry, TB & Joyner, MJ 2008, ' Measuring muscle blood flow: A key link between systemic and regional metabolism ', Current opinion in clinical nutrition and metabolic care , vol. 11, no. 5, pp. 580-586. (
  • Neurovascular coupling is the mechanism by which cerebral blood flow is matched to metabolic activity. (
  • Regional pulmonary blood flow after mitral valve surgery. (
  • Measurements of the topographical distribution of pulmonary blood flow and ventilation have been made in 26 subjects with chronic irreversible obstructive lung disease using a radioactive xenon scanning technique. (
  • The coronary blood flow was found to occur only during artificial diastole and was actually reversed during the compression phase. (
  • In contrast, exercise-induced reduction of renal flow was smaller and slower, with 18% and 25% decreases at mild and moderate exercise intensities. (
  • When the ovine fetus is exposed to asphyxia of sufficient severity to produce neurologic damage (seizures), the pattern of redistribution of blood flow is comparable to the response to lesser asphyxia, except that a significant increase in total brain blood flow does not occur. (
  • In Brain and Blood Flow , R. W. Ross Russell, ed. (
  • A detailed examination of the regional distribution of cerebral blood flow revealed that almost all brain regions were hyperperfused during diving. (
  • Because some brain regions did not increase flow significantly during diving, these results suggest that not all brain regions participate equally in the global cerebrovascular response to diving. (
  • Accordingly, we tested whether neuropsychological function and brain blood flow responses to cognitive challenges among prehypertensive individuals would predict subsequent progression of BP. (
  • Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. (
  • The ratios of regional blood flow during CPR to regional blood flow during sinus rhythm were 90% for brain, 35% for heart, 15% for kidneys, 17% for adrenal glands, 14% for pancreas, 3% for spleen, and 33% for small intestine. (
  • There is a practical way to measure metabolism, flow, and function in a localized area of brain serially in the same animal. (
  • The secondary outcomes will be vasospasm measured by CT angiography, ischaemic parameters measured by brain microdialysis, flow velocities in the medial cerebral artery, clinical parameters and outcome (Glasgow Outcome Scale) at 3 months. (
  • Importantly, despite a decreased cardiac output, relative blood flow to the head increased during diving, suggesting that there is maintenance of blood flow to the brain. (
  • He was married to Edda Sveinsdottir who as a computer scientist helped with the development of the (at that time) advanced computer technology for image construction of the regional brain measurements. (
  • By so doing, participants increase cerebral blood flow to a specified region of the brain, consequently increasing brain activity and performance on tasks involving that region of the brain. (
  • Similar to functional magnetic resonance imaging, which uses changes in the magnetic properties of blood resulting from oxygenation to form an image of brain activity, NIR utilizes the changes in blood translucence resulting from oxygenation to generate a signal that can be consciously manipulated in neurofeedback sessions. (
  • PIR uses a sensor similar to the NIR sensor to detect light from a narrow band of the infrared spectrum that corresponds to the amount of heat being generated by an active brain region, as well as the local blood oxygenation level. (
  • In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). (
  • The systemic blood flow was calculated to be between 10 and 20 per cent of its normal value. (
  • The systemic blood flow increased when pressure variations were delivered to the chest alone or when some phase lag was introduced between the thoracic and abdominal pressure waves. (
  • Regional blood flow during cardiopulmonary resuscitation in dogs" by W D. Voorhees, Charles F. Babbs et al. (
  • To determine differences in regional blood flow during cardiopulmonary resuscitation (CPR) versus normal cardiac function, we measured regional blood flow to sev~ral organs in 19 pentobarbital-anesthetized dogs (6-12 kg). (
  • and Tacker, W A., "Regional blood flow during cardiopulmonary resuscitation in dogs" (1980). (
  • Based on the new concept that intrathoracic and abdominal pressure variations cause blood flow in most of the cardiopulmonary resuscitation (CPR) techniques, two mathematical models were developed to explore related mechanisms of blood flow. (
  • We propose that postural tachycardia is related to thoracic hypovolemia during orthostasis but that the patterns of peripheral blood flow relate to different mechanisms for thoracic hypovolemia. (
  • The studies described in this Thesis were designed to investigate the patterns of cerebral blood flow (CBF) deficits that occur in Dementia of the Alzheimer Type (DAT) and relate them to performance on a variety of cognitive tasks. (
  • Dynamic computed tomography, digital subtraction angiography, and radionuclide angiography can all be used to evaluate regional blood flow noninvasively. (
  • Interventions: In an acute endotoxic shock model, norepinephrine was used to reverse hypotension in seven fluid-resuscitated pigs, anesthetized with α-chloralose and equipped with flow probes around the portal vein and renal artery, renal and jejunal mucosal laser Doppler flowmetry, and jejunal tonometry. (
  • and tended to restore renal and jejunal mucosal flows to preshock levels. (
  • Renal blood flow remained unchanged during either treatment in both the non-septic and the septic phases. (
  • Systemic hypoxemia produced large and equivalent increases in cerebral blood flow before and after chemodenervation. (
  • PIR has a poorer resolution than NIR and this treatment typically focuses on more global increases in cerebral blood flow. (
  • Cerebral blood flow (CBF) alterations after asphyxial cardiac arrest (CA) are not defined in developmental animal models or humans. (
  • Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. (
  • The influence of thiopental-induced alterations in regional blood flows on thiopental pharmacokinetics has not been determined. (
  • Since the transit-time technique gives absolute flow, independently of vessel size, and is easily implantable due to the reduced dimensions of the apparatus, it is adequate for chronic studies. (
  • Regional blood flow in chronic heart failure: the reason for the lack of correlation between patients' exercise tolerance and cardiac output? (
  • Regional spinal card blood flow in rat with chronic spinal cord compression. (
  • We found that CCs immediately provided blood flow to ischemic territories after MCAo. (
  • These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future. (
  • Zhen Wang , Weihua Luo, Fangyuan Zhou , Pengcheng Li , Qingming Luo , "Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex," Journal of Biomedical Optics 17(12), 125001 (3 December 2012). (
  • Stimulation of chemoreceptors did not increase cerebral blood flow or produce significant redistribution of cerebral blood flow, even though the chemoreflex was intact in these animals (as manifested by vasoconstriction in muscle, kidney, and small bowel) and the cerebral vessels dilated in response to systemic hypercapnia. (
  • 1 2 3 4 However, conflicting data regarding the accuracy of this method were recently presented by Harris and Bailey, 5 indicating that hypercapnia induced during general anesthesia made a very small increase in rSO 2 despite the more than doubling of the middle cerebral artery flow velocity. (
  • Surprisingly, very little is known about how such visual deprivation impacts regional cerebral blood flow velocity (CBFv) or its adaptation with the underlying neuronal activity (i.e., neurovascular coupling). (
  • The aim of this study was to describe regional differences in testicular artery blood flow in clinically normal post-pubertal and pre-pubertal dogs with no history of reproductive tract disease. (
  • The TCD measurements showed no significant differences between the blood flow in the MCAs supplying the affected and the contralateral lobe. (
  • Future research should focus on developing easily applied methods for clinical use to differentiate between central and peripheral blood flow regulation disorders in individual patients. (
  • Adequacy of microsphere mixing at low cardiac outputs was verified by comparing flow rates to paired organs. (
  • Flow to all organs sampled was less during CPR, but the relative decrease varied widely. (
  • There are a few studies of thiopental's steady-state effects on blood flows to most of the aforementioned important organs. (
  • Regional blood flow to major organs and regional cerebral blood flow were determined in seven anesthetized male gerbils by a modified microsphere method. (
  • Thus during short dynamic exercise baboons redistributed blood flow away from skin, fat, nonworking muscles, and visceral organs to supply the needs of exercising muscles. (
  • After decades of work with various biofeedback mechanisms, Toomim accidentally stumbled upon conscious control of cerebral blood flow in 1994. (
  • The distribution of blood flow was found to range between a normal gradient and the reverse of normal. (
  • The shape of the expired xenon plateau following xenon injection was usually horizontal and correlated poorly with the topographical distribution of blood flow. (
  • Although exercising skeletal muscle was shown to modify the peripheral distribution of blood flow during diving, the brain's share of cardiac output increases primarily due to a decrease in cerebrovascular resistance. (