Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Brachial Plexus Neuropathies
Diseases of the cervical (and first thoracic) roots, nerve trunks, cords, and peripheral nerve components of the BRACHIAL PLEXUS. Clinical manifestations include regional pain, PARESTHESIA; MUSCLE WEAKNESS, and decreased sensation (HYPESTHESIA) in the upper extremity. These disorders may be associated with trauma (including BIRTH INJURIES); THORACIC OUTLET SYNDROME; NEOPLASMS; NEURITIS; RADIOTHERAPY; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp1351-2)
National Academy of Sciences (U.S.)
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
Encyclopedias as Topic
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Dental Implantation, Endosseous
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
The religion stemming from the life, teachings, and death of Jesus Christ: the religion that believes in God as the Father Almighty who works redemptively through the Holy Spirit for men's salvation and that affirms Jesus Christ as Lord and Savior who proclaimed to man the gospel of salvation. (From Webster, 3d ed)
Guided Tissue Regeneration
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle. (1/5339)To gain insight into the regeneration deficit of MyoD-/- muscle, we investigated the growth and differentiation of cultured MyoD-/- myogenic cells. Primary MyoD-/- myogenic cells exhibited a stellate morphology distinct from the compact morphology of wild-type myoblasts, and expressed c-met, a receptor tyrosine kinase expressed in satellite cells. However, MyoD-/- myogenic cells did not express desmin, an intermediate filament protein typically expressed in cultured myoblasts in vitro and myogenic precursor cells in vivo. Northern analysis indicated that proliferating MyoD-/- myogenic cells expressed fourfold higher levels of Myf-5 and sixfold higher levels of PEA3, an ETS-domain transcription factor expressed in newly activated satellite cells. Under conditions that normally induce differentiation, MyoD-/- cells continued to proliferate and with delayed kinetics yielded reduced numbers of predominantly mononuclear myocytes. Northern analysis revealed delayed induction of myogenin, MRF4, and other differentiation-specific markers although p21 was upregulated normally. Expression of M-cadherin mRNA was severely decreased whereas expression of IGF-1 was markedly increased in MyoD-/- myogenic cells. Mixing of lacZ-labeled MyoD-/- cells and wild-type myoblasts revealed a strict autonomy in differentiation potential. Transfection of a MyoD-expression cassette restored cytomorphology and rescued the differentiation deficit. We interpret these data to suggest that MyoD-/- myogenic cells represent an intermediate stage between a quiescent satellite cell and a myogenic precursor cell. (+info)
Lack of regulation in the heart forming region of avian embryos. (2/5339)The ability to regenerate a heart after ablation of cardiogenic mesoderm has been demonstrated in early stage fish and amphibian embryos but this type of regulation of the heart field has not been seen in avians or mammals. The regulative potential of the cardiogenic mesoderm was examined in avian embryos and related to the spatial expression of genes implicated in early cardiogenesis. With the identification of early cardiac regulators such as bmp-2 and nkx-2.5, it is now possible to reconcile classical embryological studies with molecular mechanisms of cardiac lineage determination in vivo. The most anterior lateral embryonic cells were identified as the region that becomes the heart and removal of all or any subset of these cells resulted in the loss of corresponding cardiac structures. In addition, removal of the lateral heart forming mesoderm while leaving the lateral endoderm intact also results in loss of cardiac structures. Thus the medial anterior mesoderm cannot be recruited into the heart lineage in vivo even in the presence of potentially cardiac inducing endoderm. In situ analysis demonstrated that genes involved in early events of cardiogenesis such as bone morphogenetic protein 2 (bmp-2) and nkx-2.5 are expressed coincidentally with the mapped far lateral heart forming region. The activin type IIa receptor (actR-IIa) is a potential mediator of BMP signaling since it is expressed throughout the anterior mesoderm with the highest level of expression occurring in the lateral prospective heart cells. The posterior boundary of actR-IIa is consistent with the posterior boundary of nkx-2.5 expression, supporting a model whereby ActR-IIa is involved in restricting the heart forming region to an anterior subset of lateral cells exposed to BMP-2. Analysis of the cardiogenic potential of the lateral plate mesoderm posterior to nkx-2.5 and actR-IIa expression demonstrated that these cells are not cardiogenic in vitro and that removal of these cells from the embryo does not result in loss of heart tissue in vivo. Thus, the region of the avian embryo that will become the heart is defined medially, laterally, and posteriorly by nkx-2.5 gene expression. Removal of all or part of the nkx-2.5 expressing region results in the loss of corresponding heart structures, demonstrating the inability of the chick embryo to regenerate cardiac tissue in vivo at stages after nkx-2.5 expression is initiated. (+info)
Expression and developmental regulation of the Hydra-RFamide and Hydra-LWamide preprohormone genes in Hydra: evidence for transient phases of head formation. (3/5339)Hydra magnipapillata has three distinct genes coding for preprohormones A, B, and C, each yielding a characteristic set of Hydra-RFamide (Arg-Phe-NH2) neuropeptides, and a fourth gene coding for a preprohormone that yields various Hydra-LWamide (Leu-Trp-NH2) neuropeptides. Using a whole-mount double-labeling in situ hybridization technique, we found that each of the four genes is specifically expressed in a different subset of neurons in the ectoderm of adult Hydra. The preprohormone A gene is expressed in neurons of the tentacles, hypostome (a region between tentacles and mouth opening), upper gastric region, and peduncle (an area just above the foot). The preprohormone B gene is exclusively expressed in neurons of the hypostome, whereas the preprohormone C gene is exclusively expressed in neurons of the tentacles. The Hydra-LWamide preprohormone gene is expressed in neurons located in all parts of Hydra with maxima in tentacles, hypostome, and basal disk (foot). Studies on animals regenerating a head showed that the prepro-Hydra-LWamide gene is expressed first, followed by the preprohormone A and subsequently the preprohormone C and the preprohormone B genes. This sequence of events could be explained by a model based on positional values in a morphogen gradient. Our head-regeneration experiments also give support for transient phases of head formation: first tentacle-specific preprohormone C neurons (frequently associated with a small tentacle bud) appear at the center of the regenerating tip, which they are then replaced by hypostome-specific preprohormone B neurons. Thus, the regenerating tip first attains a tentacle-like appearance and only later this tip develops into a hypostome. In a developing bud of Hydra, tentacle-specific preprohormone C neurons and hypostome-specific preprohormone B neurons appear about simultaneously in their correct positions, but during a later phase of head development, additional tentacle-specific preprohormone C neurons appear as a ring at the center of the hypostome and then disappear again. Nerve-free Hydra consisting of only epithelial cells do not express the preprohormone A, B, or C or the LWamide preprohormone genes. These animals, however, have a normal phenotype, showing that the preprohormone A, B, and C and the LWamide genes are not essential for the basic pattern formation of Hydra. (+info)
Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery. (4/5339)Although recent studies have provided evidence for hair cell regeneration in mammalian inner ears, the mechanism underlying this regenerative process is still under debate. Here we report immunocytochemical, histological, electron microscopic, and autoradiographic evidence that, in cultured postnatal rat utricles, a substantial number of hair cells can survive gentamicin insult even their stereocilia are lost. These partially damaged hair cells can survive for a prolonged time and regrow the stereocilia. Although the number of stereocilia-bearing hair cells increases over time after gentamicin insult, hair cell and supporting cell numbers remain essentially unchanged. Tritiated thymidine autoradiography and bromodeoxyuridine immunocytochemistry of the cultures demonstrate that cell proliferation in the sensory epithelium is very limited and is far below the number of recovered hair cells. Furthermore, terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling analysis indicates that gentamicin-induced apoptosis in the sensory epithelium occurs mainly during a 2 d treatment period, and additional cell death is minimal 2-11 d after treatment. Considered together, intracellular repair of partially damaged hair cells can be an important contributor to spontaneous hair cell recovery in mammalian inner ears. (+info)
Alteration of endothelium-dependent hyperpolarizations in porcine coronary arteries with regenerated endothelium. (5/5339)The present study was designed to test the ability of regenerated endothelium to evoke endothelium-dependent hyperpolarizations. Hyperpolarizations induced by serotonin and bradykinin were compared in isolated porcine coronary arteries with native or regenerated endothelium, 4 weeks after balloon endothelial denudation. The experiments were performed in the presence of inhibitors of nitric oxide synthase (Nomega-nitro-L-arginine) and cyclooxygenase (indomethacin). The transmembrane potential was measured using conventional glass microelectrodes. Smooth muscle cells from coronary arteries with regenerated endothelium were depolarized in comparison with control coronary arteries from the same hearts. Spontaneous membrane potential oscillations of small amplitude or spikes were observed in some of these arteries but never in arteries with native endothelium. In coronary arteries from control pigs, both serotonin and bradykinin induced concentration-dependent hyperpolarizations. In the presence of ketanserin, 10 micromol/L serotonin induced a transient hyperpolarization in control coronary arteries. Four weeks after balloon denudation, the response to serotonin was normal in arteries with native endothelium, but the hyperpolarization was significantly lower in coronary arteries with regenerated endothelium. In control arteries, the endothelium-dependent hyperpolarization obtained with bradykinin (30 nmol/L) was reproducible. Four weeks after balloon denudation, comparable hyperpolarizations were obtained in coronary arteries with native endothelium. By contrast, in arteries with regenerated endothelium, the hyperpolarization to bradykinin became voltage-dependent. In the most depolarized cells, the hyperpolarization to bradykinin was augmented. The changes in resting membrane potential and the alteration in endothelium-dependent hyperpolarizations observed in the coronary arteries with regenerated endothelium may contribute to the reduced response to serotonin and the unchanged relaxation to bradykinin described previously. (+info)
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. (6/5339)Islet duodenal homeobox 1 (IDX-1/PF-1/STF-1/PDX-1), a homeodomain protein that transactivates the insulin promoter, has been shown by targeted gene ablation to be required for pancreatic development. After 90% pancreatectomy (Px), the adult pancreas regenerates in a process recapitulating embryonic development, starting with a burst of proliferation in the epithelium of the common pancreatic duct. In this model, IDX-1 mRNA was detected by semiquantitative reverse transcription-polymerase chain reaction in total RNA from isolated common pancreatic ducts at levels 10% of those of isolated islets. The IDX-1 mRNA levels were not significantly different for common pancreatic ducts of Px, sham Px, and unoperated rats and did not change with time after surgery. By immunoblot analysis, IDX-1 protein was only faintly detected in these ducts 1 and 7 days after Px or sham Px but was easily detected at 2 and 3 days after Px. Similarly, IDX-1 immunostaining was barely detectable in sham or unoperated ducts but was strong in ducts at 2-3 days after Px. The increase of IDX-1 immunostaining followed that of BrdU incorporation (proliferation). These results indicate a posttranscriptional regulation of the IDX-1 expression in ducts. In addition, islets isolated 3-7 d after Px showed higher IDX-1 protein expression than control islets. Thus, in pancreatic regeneration IDX-1 is upregulated in newly divided ductal cells as well as in islets. The timing of enhanced expression of IDX-1 implies that IDX-1 is not important in the initiation of regeneration but may be involved in the differentiation of ductal cells to beta-cells. (+info)
Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs. (7/5339)Surgically fragmented Drosophila appendage primordia (imaginal discs) engage in wound healing and pattern regulation during short periods of in vivo culture. Prothoracic leg disc fragments possess exceptional regulative capacity, highlighted by the ability of anterior cells to convert to posterior identity and establish a novel posterior compartment. This anterior/posterior conversion violates developmental lineage restrictions essential for normal growth and patterning of the disc, and thus provides an ideal model for understanding how cells change fate during epimorphic pattern regulation. Here we present evidence that the secreted signal encoded by hedgehog directs anterior/posterior conversion by activating the posterior-specific transcription factor engrailed in regulating anterior cells. In the absence of hedgehog activity, prothoracic leg disc fragments fail to undergo anterior/posterior conversion, but can still regenerate missing anterior pattern elements. We suggest that hedgehog-independent regeneration within the anterior compartment (termed integration) is mediated by the positional cues encoded by wingless and decapentaplegic. Taken together, our results provide a novel mechanistic interpretation of imaginal disc pattern regulation and permit speculation that similar mechanisms could govern appendage regeneration in other organisms. (+info)
Transforming growth factor-beta-induced upregulation of transforming growth factor-beta receptor expression in pancreatic regeneration. (8/5339)The transforming growth factor-beta (TGFbeta) signaling pathway is one important player in the regulation of extracellular matrix turnover and cell proliferation in epithelial regeneration. We used cerulein-induced pancreatitis in rats as a model to investigate the regulation of TGFbeta receptor type I and type II expression on protein and messenger RNA level during regeneration. In the regenerating pancreas, mRNA levels of TGFbeta receptor I and II were significantly increased with a maximum after 2 days. On protein level, expression of TGFbeta receptor II was significantly increased after three to 3-5 days. This elevated expression could be inhibited by neutralizing the endogenous biological activity of TGFbeta1 with a specific antibody. In cultured pancreatic epithelial cells, TGFbeta1 reduced cell proliferation as measured by [3H]thymidine incorporation. Furthermore the transcript levels of TGFbeta1 as well as mRNA and protein concentrations of type I and type II receptor increased during TGFbeta stimulation in vitro. These results indicate that epithelial pancreatic cells contribute to the enhanced TGFbeta1 synthesis during pancreatic regeneration by an autocrine mechanism. TGFbeta1, furthermore, upregulates the expression of its own receptors during the regenerative process, thereby contributing to the increase of the TGFbeta-induced cellular responses. (+info)
Adult Stem Cells and Skeletal Muscle Regeneration | Bentham Science
Title:Adult Stem Cells and Skeletal Muscle Regeneration. VOLUME: 15 ISSUE: 4. Author(s):Domiziana Costamagna, Emanuele Berardi, Gabriele Ceccarelli and Maurilio Sampaolesi. Affiliation:Translational Cardiomyology Laboratory, Stem Cell Institute Leuven, KU Leuven, Belgium.. Keywords:Adult stem cells, Muscular dystrophy, Skeletal muscle regeneration.. Abstract:Satellite cells are unipotent stem cells involved in muscle regeneration. However, the skeletal muscle microenvironment exerts a dominant influence over stem cell function. The cell intrinsic complexity of the skeletal muscle niche located within the connective tissue between fibers includes motor neurons, tendons, blood vessels, immune response mediators and interstitial cells. All these cell types modulate the trafficking of stimuli responsible of muscle fiber regeneration. In addition, several stem cell types have been discovered in skeletal muscle tissue, mainly located in the interstitium. The majority of these stem cells appears to ...
NESPS - Extracellular Matrix Impregnated with Adipose Derived Stem Cells in Skeletal Muscle Regeneration following Volumetric...
2016 Annual Meeting: Extracellular Matrix Impregnated with Adipose Derived Stem Cells in Skeletal Muscle Regeneration following Volumetric Muscle Loss in a Murine Model
Ellex Demonstrates Laser Retina Regeneration Therapy Clinical Efficacy - NS Medical Devices
Ellex Medical Lasers, a provider in the design and manufacture of ophthalmic laser and ultrasound systems, has presented positive clinical results for its laser Retina Regeneration Therapy (Ellex 2RT) for the treatment of age-related macular degeneration (AMD) and diabetic retinopathy (DR), two conditions that usually result in irreversible blindness for sufferers. Ellex 2RT treatment involves a laser device designed and manufactured by Ellex which delivers a controlled nanosecond dose of laser energy into the eye.. The company said that the clinical trials of Ellex 2RT demonstrate the potential to reverse the degenerative processes caused by the disease AMD through the reduction of yellow deposits known as drusen, present in the retinal tissue of people suffering from AMD.. Ellex 2RT offers the potential to treat AMD in its early stages, before vision is lost. Until now treatment has been restricted to targeting late-stage complications associated with the wet form of AMD, which only accounts ...
Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies : Response to Gyöngyösi, Wojakowski, Navarese, Moyé, and...
Gyöngyösi, Mariann; Wojakowski, Wojciech; Navarese, Eliano P; Moye, Lemuel À (2016). Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies : Response to Gyöngyösi, Wojakowski, Navarese, Moyé, and the ACCRUE Investigators. Circulation Research, 118(8):1254-1263. ...
Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae<...
TY - JOUR. T1 - Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae. AU - Rodrigues, Alexandre Miguel Cavaco. AU - Christen, Bea. AU - Martí, Mercé. AU - Izpisua Belmonte, Juan Carlos. PY - 2012/4/3. Y1 - 2012/4/3. N2 - Background: Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature cells via dedifferentiation and/or from stem cells. Several studies in urodele amphibians (salamanders) indicate that, after limb or tail amputation, the multinucleated muscle fibres do dedifferentiate by fragmentation and proliferation, thereby contributing to the regenerate. In Xenopus laevis tadpoles, however, it was shown that muscle fibres do not contribute directly to the tail regenerate. We set out to study whether dedifferentiation was present during muscle regeneration of the tadpole limb and zebrafish larval tail, mainly by cell ...
US9138317B2 - Conduits for enhancing tissue regeneration - Google Patents
Apparatuses, systems, and methods for enhancing bone or soft tissue regeneration are provided. For example, a conduit, having one or more segments, can originate at a tissue regeneration site and can have a first opening to promote physiological signals to enter the conduit and transit to a second opening that penetrates a histologically rich source of multipotent mesenchymal cells, promoting the multipotent mesenchymal cells to produce tissue regeneration response products, the response products transiting through the second opening to egress at the first opening of the conduit, and promoting tissue regeneration at the tissue regeneration site. Transit of the physiological signals and the tissue regeneration response products is promoted through physical and/or chemical means, as is promotion of the anatomical functionality of the regenerated tissue. For example, a number of the segments of the conduit can be formed at least partially from an osteoceramic material.
Tissue Engineering And Organ Regeneration Market : 2013 - 2019: Transparency Market Research
Tissue engineering and organ regeneration market encompasses those products used in medicine. The application of these new age biomaterials include burn treatment or wound care, orthopaedics, urological products, and neurology products. Engineered cell growth has been present over the past many years with little or no applications in medicine. Recent developments and progress in the field of stem cell technology, cell culture technology and immunopassivation and immunomodulation has provided incredible opportunities to market players. Several cardiovascular applications such as heart valve and myocardial tissue regeneration is also expected to provide excellent sustainability for the growth of the market. Rising cost of organ transplantation, long waiting lines and rising medical applications of 3D printing in tissue and organ regeneration will be the major growth drivers for this market in the near future.. Browse the full report with request TOC at ...
Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish...
Here, we used classical genetics in zebrafish to identify temperature-sensitive mutants in caudal fin regeneration. Gross morphological, histological, and molecular analyses revealed that one of these strains, emmental (emm), failed to form a functional regeneration blastema. Inhibition of emm function by heat treatment during regenerative outgrowth rapidly blocked regeneration. This block was associated with reduced proliferation in the proximal blastema and expansion of the nonproliferative distal blastemal zone. Positional cloning revealed that the emm phenotype is caused by a mutation in the orthologue of yeast sly1, a gene product involved in protein trafficking. sly1 is upregulated in the newly formed blastema as well as during regenerative outgrowth. Thus, sly1 is essential for blastemal organization and proliferation during two stages of fin regeneration ...
Cartilage Regeneration Stem Cell Therapy, Stem Cell Therapy, Chennai, India
Cheapest Cartilage Regeneration Stem Cell Therapy price in Chennai, India is $6000. Average Cartilage Regeneration Stem Cell Therapy cost $8000, where prices can go as high as $10000. PlacidWay Medical Tourism provides cost comparison for Cartilage Regeneration Stem Cell Therapy, Stem Cell Therapy Prices in Chennai, India. Explore Cartilage Regeneration Stem Cell Therapy prices worldwide.
Greengate regeneration strategy • Salford City Council
Greengate is the medieval heart of the city of Salford and lies on the Salford - Manchester border. Greengate has been a key investment focus of the council for a number of years now, with a vision to create a new corporate centre for Salford.. There are still a number of key opportunities for further development within the area and Salford City Council therefore commissioned Urban Vision (planning consultants), and Feilden Clegg Bradley Studios, (architects and masterplanners) to update the regeneration strategy during 2017. We have now reached a stage where we wish to consult on the new draft regeneration strategy (at the bottom of the page).. We are undertaking an eight week consultation on the draft regeneration strategy starting on 27 November 2017.. As part of the consultation, we will be holding a drop-in session on the 13 December 2017 at Block 12, Spectrum, Blackfriars Road, Salford between 1pm and 7pm (access from Blackfriars Road). This will be an opportunity to meet officers from ...
Macrophages are required for neonatal heart regeneration<...
TY - JOUR. T1 - Macrophages are required for neonatal heart regeneration. AU - Aurora, Arin B.. AU - Porrello, Enzo R.. AU - Tan, Wei. AU - Mahmoud, Ahmed I.. AU - Hill, Joseph A.. AU - Bassel-Duby, Rhonda. AU - Sadek, Hesham A.. AU - Olson, Eric N.. PY - 2014/3/3. Y1 - 2014/3/3. N2 - Myocardial infarction (MI) leads to cardiomyocyte death, which triggers an immune response that clears debris and restores tissue integrity. In the adult heart, the immune system facilitates scar formation, which repairs the damaged myocardium but compromises cardiac function. In neonatal mice, the heart can regenerate fully without scarring following MI; however, this regenerative capacity is lost by P7. The signals that govern neonatal heart regeneration are unknown. By comparing the immune response to MI in mice at P1 and P14, we identified differences in the magnitude and kinetics of monocyte and macrophage responses to injury. Using a cell-depletion model, we determined that heart regeneration and ...
Stem cells and cardiac regeneration research debunked | Cardio Debate
US funding for research into cardiac regeneration using stem cells is coming to an end after a five-year investigation revealed over 30 studies in this field must be retracted. In October 2018, The New York Times reported that Harvard and Bringham and ...
Regeneration from a Cell Biological Perspective-Fascinating New Insights and Paradigms
Regeneration research is more focused on translational values. However, lying at its very foundation is an understanding of how tissues and organs repair and renew themselves at the cellular level. The past decade has witnessed paradigm changing advances in regenerative biology, many of these stems from novel insights into stemness, pluripotency, cell death and their related intra- and inter-cellular biochemical and molecular processes. Some of these new insights are highlighted in the paragraphs that follow. We now have a much better understanding of how regeneration occurs in lower organisms. We have also discovered tools and means of nuclear reprogramming to generate induced pluripotency and changes in cell fate in mammalian models. With further research, there is reasonable hope that various obstacles of regeneration in humans can be better understood and tackled. As regeneration research enters a new era, CellBio welcomes timely review articles and original papers on the theme of
c-MET Regulates Myoblast Motility and Myocyte Fusion during Adult Skeletal Muscle Regeneration - pdf descargar
c-MET Regulates Myoblast Motility and Myocyte Fusion during Adult Skeletal Muscle Regeneration. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Catalysts | Free Full-Text | Catalyst Deactivation and Regeneration Processes in Biogas Tri-Reforming Process. The Effect of...
This work studies Ni-based catalyst deactivation and regeneration processes in the presence of H2S under a biogas tri-reforming process for hydrogen production, which is an energy vector of great interest. 25 ppm of hydrogen sulfide were continuously added to the system in order to provoke an observable catalyst deactivation, and once fully deactivated two different regeneration processes were studied: a self-regeneration and a regeneration by low temperature oxidation. For that purpose, several Ni-based catalysts and a bimetallic Rh-Ni catalyst supported on alumina modified with CeO2 and ZrO2 were used as well as a commercial Katalco 57-5 for comparison purposes. Ni/Ce-Al2O3 and Ni/Ce-Zr-Al2O3 catalysts almost recovered their initial activity. For these catalysts, after the regeneration under oxidative conditions at low temperature, the CO2 conversions achieved-79.5% and 86.9%, respectively-were significantly higher than the ones obtained before sulfur poisoning-66.7% and 45.2%, respectively. This
Increased susceptibility to streptozotocin and impeded regeneration capacity of beta-cells in adult offspring of malnourished...
Background: Epidemiological studies related poor maternal nutrition and subsequent growth retardation in the progeny to the development of diabetes later in life. Low-protein diet during gestation altered the beta-cell development of the rat progeny by decreasing beta-cell proliferation and increasing their sensitivity to nitric oxide and cytokines in the foetus. This disturbed maternal environment had long-lasting consequences because the higher beta-cell vulnerability was maintained at adulthood. Aim: The aim of this study was to determine whether early malnutrition influences the vulnerability and the regeneration capacity of beta-cells after streptozotocin (STZ) damage at adulthood. Methods: Gestating rats were fed either a control or a low-protein diet until weaning. Adult female offspring received injections of Freunds adjuvant weekly for 5 weeks followed 24 h later by STZ. Half of the cohort was killed at d34, whereas the other half was maintained until d48 to analyse the regeneration ...
ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar...
The pancreas is a vertebrate-specific endodermal organ executing major functions in food digestion and glucose homeostasis. The mature organ is composed of an exocrine compartment with acinar and duct cells that produce and transport digestive enzymes into the gut, and an endocrine compartment from which metabolism-regulating peptide hormones including insulin are secreted into the blood stream. Studies on pancreas regeneration have focused mainly on the endocrine compartment, with the aim of gaining knowledge on β-cell regeneration. More recently, exocrine pancreas regeneration has been receiving more attention in the context of cancer and diabetes research because experimental models revealed a high capacity for cell fate plasticity (Murtaugh and Keefe, 2015).. Regeneration of exocrine tissue has been mainly studied in mouse models, where the loss of cells can be induced by caerulein treatment or partial duct ligation (Aghdassi et al., 2011; Lerch and Gorelick, 2013). Using these procedures, ...
RegenaDISC℠ Disc Regeneration Therapy Can Provide Relief for Painful Backs
Austin, TX (Vocus) November 4, 2010 -- Back pain or neck pain that isnt quickly resolved with the help of painkillers or physical therapy can be debilitating,
Phase III clinical trials for stem cell-based cartilage regeneration therapy have started -- COMPAMED Trade Fair
A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.
My Dog Shebas Amazing Progress with Stem Cell Regeneration Therapy
Since receiving injections of her own adult (autologous) stem cells in April, my dog Sheba has been steadily growing stronger, overcoming the pain of the crippling arthritis...
The role of mechanosensitve ion channels during zebrafish heart regeneration - TEL - Thèses en ligne
In humans, most cardiovascular disorders lead to the destruction of cardiac tissue which will be replaced by fibrosis, leading to arrhythmia and reduced contractile function, resulting in an increase in ventricular load. In order to maintain an overall cardiac output, cardiomyocytes undergo hypertrophic response, leading to pathological hypertrophy and heart failure. This increase in ventricular load, have to be sensed by mechanosensors such as the mechanosensitive ion channels such as TREK-1. Unlike mammals, adult zebrafish (zf) can fully regenerate their heart after an extensive insult through cardiomyocyte dedifferentiation followed by proliferation. We believe that in adult mammals, cardiomyocyte proliferation has been blocked/inhibited. Therefore its likely that genes which respond to increased ventricular load in mammals and trigger pathological hypertrophy will trigger cardiomyocyte proliferation during heart regeneration in zf. In this study we show that zTREK1a and zTREK1b have similar
Loss of Thy-1 may reduce lung regeneration after pneumonectomy in mice - Minerva Medica 2020 Jul 20 - Minerva Medica - Journals
article: Loss of Thy-1 may reduce lung regeneration after pneumonectomy in mice - Minerva Medica 2020 Jul 20 - Minerva Medica - Journals
Towards Minimally Invasive Exosome Therapies for Internal Organ Regeneration - News - LONGECITY
Towards Minimally Invasive Exosome Therapies for Internal Organ Regeneration - posted in News: Targeted delivery of therapeutics remains one of the thorny issues in medical development. Everyone wants a way to deliver high doses of a therapeutic to a specific location in the body without it also ending up everywhere else. The major issue is that systemic administration will send the majority of whatever is injected into the body into the liver and lungs, and that limits the dose that can b...
New Discovery May Bring Lung Regeneration Closer to Reality | www.bioquicknews.com
Researchers at Weill Cornell Medical College, and colleagues, say they have taken an important step forward in their quest to turn on lung regeneration -- an advance that could effectively treat millions of people suffering from respiratory disorders. In the October 28, 2011 issue of Cell, the research team reports that they have uncovered the biochemical signals in mice that trigger generation of new lung alveoli, the numerous, tiny, grape-like sacs within the lung where oxygen exchange takes place. Specifically, the regenerative signals originate from the specialized endothelial cells that line the interior of blood vessels in the lung. While it has long been known that mice can regenerate and expand the capacity of one lung if the other is missing, this study now identifies molecular triggers behind this process, and the researchers believe these findings are relevant to humans. Several adult human organs have the potential upon injury to regenerate to a degree, and while we can readily ...
A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. - Radcliffe...
Macrophages play an essential role in the resolution of tissue damage through removal of necrotic cells, thus paving the way for tissue regeneration. Macrophages also directly support the formation of new tissue to replace the injury, through their acquisition of an anti-inflammatory, or M2, phenotype, characterized by a gene expression program that includes IL-10, the IL-13 receptor, and arginase 1. We report that deletion of two CREB-binding sites from the Cebpb promoter abrogates Cebpb induction upon macrophage activation. This blocks the downstream induction of M2-specific Msr1, Il10, II13ra, and Arg-1 genes, whereas the inflammatory (M1) genes Il1, Il6, Tnfa, and Il12 are not affected. Mice carrying the mutated Cebpb promoter (betaDeltaCre) remove necrotic tissue from injured muscle, but exhibit severe defects in muscle fiber regeneration. Conditional deletion of the Cebpb gene in muscle cells does not affect regeneration, showing that the C/EBPbeta cascade leading to muscle repair is muscle
Macrophage stimulating protein may promote tubular regeneration after acute injury<...
TY - JOUR. T1 - Macrophage stimulating protein may promote tubular regeneration after acute injury. AU - Cantaluppi, Vincenzo. AU - Biancone, Luigi. AU - Romanazzi, Giuseppe Mauriello. AU - Figliolini, Federico. AU - Beltramo, Silvia. AU - Galimi, Francesco. AU - Camboni, Maria Gavina. AU - Deriu, Elisa. AU - Conaldi, Piergiulio. AU - Bottelli, Antonella. AU - Orlandi, Viviana. AU - Herrera, Maria Beatriz. AU - Pacitti, Alfonso. AU - Segoloni, Giuseppe Paolo. AU - Camussi, Giovanni. PY - 2008/10. Y1 - 2008/10. N2 - Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after transplantation. In addition, MSP and its receptor, RON, were markedly upregulated in the regenerative phase after glycerol-induced tubular ...
KAKEN - Research Projects | The periodontal regeneration therapy with novel amelogenin binding protein Grp78 (KAKENHI-PROJECT...
Principal Investigator：Toyoda Kyosuke, Project Period (FY)：2015-08-28 - 2017-03-31, Research Category：Grant-in-Aid for Research Activity start-up, Research Field：Periodontology
Scientists identify mammal model of bladder regeneration | EurekAlert! Science News
A mammal model of true organ regeneration may help scientists better understand this process so that they can prompt the regeneration of human organs.
Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration | PNAS
An abundance of data across several vertebrate taxon groups (3, 11, 12) suggests that nerves may have a conserved evolutionary role that is essential to, or permissive for, limb regeneration. Despite the absence of innervation to the hind limb throughout the time of regeneration, the mouse model replaces the amputated digit tip with surprising fidelity in most tissue types. Our comprehensive examination at single-cell levels of primary hind limb tissues during normal maintenance, regeneration, and wound healing reveals that many presumed tissue stem/progenitor cells maintain clonal and differentiation capabilities in the absence of nerve supply.. In salamander embryos, removal of a large section of the neural tube leads to limb development without innervation. These limbs can be transplanted to the flank of a normal larva, where they can regenerate in the absence of nerve supply (33). This lack of nerve dependence is made possible by the substitution of nerve-derived factors from ectodermal ...
Neuron regeneration may help sufferers of brain injury, Alzheimers disease
Researchers at Penn State have developed an innovative technology to regenerate functional neurons after brain injury and also in model systems used for research on Alzheimers disease.
invertebrates inspire new breakthrough in nerve regeneration therapy, country music and suicide, most states fail science...
New procedure repairs severed nerves in minutes, restoring limb use in days or weeks The team studied the mechanisms all animal cells use to repair damage to their membranes and focused on invertebrates, which have a superior ability to regenerate nerve axons compared to mammals. An axon is a long extension arising from a nerve…
Potential for in body muscle regeneration - Sonia Arrison
New research in mice and rats, conducted at Wake Forest Baptist Medical Centers Institute for Regenerative Medicine, suggests that in body regeneration of muscle tissue might be possible by harnessing the bodys natural healing powers.. Reporting online ahead of print in the journal Acta Biomaterialia, the research team demonstrated the ability to recruit stem cells that can form muscle tissue to a small piece of biomaterial, or scaffold that had been implanted in the animals leg muscle. The secret to success was using proteins involved in cell communication and muscle formation to mobilize the cells.. Working to leverage the bodys own regenerative properties, we designed a muscle-specific scaffolding system that can actively participate in functional tissue regeneration, said Sang Jin Lee, Ph.D., assistant professor of regenerative medicine and senior author. This is a proof-of-concept study that we hope can one day be applied to human patients. ...
CellNEWS: New Study Casts Doubt on Heart Regeneration in Mammals
The mammalian heart has generally been considered to lack the ability to repair itself after injury, but a 2011 study in new-born mice challenged this view, providing evidence for complete regeneration after resection of 10% of the apex. However, in this study researchers attempted to replicate these recent findings but failed to uncover any evidence of complete heart regeneration in new-born mice that underwent apex resection.
Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells | The EMBO Journal
In response to a severe injury that destroys a majority of the tissue, skeletal muscle is capable of complete regeneration and restoration of the cytoarchitecture within a 2‐week period (Miller et al, 1999; Seale and Rudnicki 2000; Shi and Garry 2006). This remarkable regenerative capacity is due to a rare population of cells termed myogenic progenitor cells that are resident in adult skeletal muscle. Although intense interest has been directed toward muscle regeneration, the molecular mechanisms that direct the MPC population are incompletely defined. In the present study, we have begun to decipher the MPC regulatory program by making three principal findings that enhance our mechanistic understanding of the MPC population. First, we utilized transgenic technology to define modular sequences of the Foxk1 gene that directs lacZ reporter expression to the MPC population. We have previously demonstrated that Foxk1 is restricted to the MPC population in adult skeletal muscle (Garry et al, 1997, ...
CNIC scientists describe the mechanism of heart regeneration in the zebrafish - Scienmag: Latest Science and Health News
Before the new study, scientists did not know if all cardiomyocytes in the zebrafish heart shared the same regenerative ability or if they were equally able to regenerate all zones of the heart muscle. Cell plasticity, the ability of cells to convert themselves into another cell type, is frequently observed during embryonic development, but has never before been reported during tissue regeneration in an adult organism. In the study, which received funding from the European Research Council (ERC Starting Grant 2013 337703 zebraHeart), the authors investigated two types of cardiomyocyte, one localized in the innermost heart regions, the trabeculae, and the other in the exterior heart wall. Scientists had presumed that during regeneration each cardiomyoctye population would give rise only to the same specialized cell type. But the CNIC study shows that cardiomyocytes from the trabeculae can contribute to the regeneration of the external heart wall. The researchers conclude that their results ...
High-throughput direct regeneration of soybean mutant and common lines from cotyledonary node
Direct regenerations by using mature cotyledonary node as a explants has been shown to be time-saving and convenient strategy for micropropagation of soybean. So we have evaluated regeneration protocol through single shoot using cotyledonary node as a rapid and efficient protocol for two soybean cultivars and one mutant line. Cotyledonary nodes explants obtained from 7-days-old in vitro seedlings. After 28 days, the percent of regeneration and after 42 days, regeneration area were calculated. The results showed that percent of regeneration and regeneration area of mutant line was significantly more than two cultivars, L17 and Williams. After shoot induction, plants were transferred to shoot elongation medium followed by transferring plants to rooting medium. The results showed that the percent of rooting was not significantly affected by genotypes. In another experiment to test kanamycin sensitivity of regenerated shoots, it was found that kanamaycin with 150 mg/L concentration is lethal for
Daniels Place - (Reformata et semper reformanda): Regeneration and the means of grace
In an earlier post, I pointed out the problems with trying to do away with the term regeneration by attempting to subsume regeneration under the category of effectual calling. But while I agree regeneration is a distinct (note: not separate) act from effectual calling, I agreed that it was through Gods Word in effectual calling that regeneration happens.. In his article on the topic however, John Murray goes further, trying to distinguish between two types of regeneration. The first is unmediated by the proclaimed Word but purely of divine fiat. The second is mediated by the proclaimed Word (pp. 196-7). In a certain sense, we can say that some people seem to show signs of regeneration prior to the proclamation of the Gospel, but is that a real example of someone who is regenerated by divine fiat alone apart from the proclaimed Word?. It is my contention that Murray is wrong here. While certainly there is a distinction between the divine fiat Word, and the proclaimed Word, yet, inasmuch as the ...
Liberum Arbitrium: the transhuman condition
Regeneration is the ability to restore lost or damaged tissues, organs or limbs. It is a common feature in invertebrates, but far more limited in most vertebrates. Nevertheless, even humans possess some degree of regeneration ability. Children under 6 years of age are capable of regenerating lost fingertips and the human liver retains its ability to regenerate throughout a persons lifetime. Aside from being used to generally describe any number of specific healing processes, regeneration also is a specific method of healing that is noted for its ability to regrow lost limbs, severed nerve connections, and other wounds. This is present in some animals such as the newt, hydra, and a type of mouse.  . With the exception of the MRL mice, mammals do not in general have the ability to regenerate. If the processes behind regeneration are fully understood, it is believed this would lead to better treatment for individuals with nerve injuries, broken backs, paralysis, and missing limbs ...
Gene Linked to Pediatric Kidney Cancer May Be Key to Kidney Regeneration | UKRO - Funding kidney research today for a healthier...
Researchers from Boston Childrens Hospital have discovered that the Lin28 gene, which is linked to Wilms tumor, may be the key to kidney regeneration.
BP drug improves muscle regeneration | IronMag Bodybuilding Blog
To investigate losartans role in muscle injury regeneration in the context of aging, the Hopkins team worked with 40 mice which, at 21-months old, were considered geriatric. The researchers examined the stained muscle tissue under a microscope at four days and again at 19 days, looking for signs of regeneration: small fibers with larger-than-usual nuclei.. After four days, they saw no difference in the number of regenerating fibers between the losartan-treated mice and those not treated. However, after 19 days, the losartan-treated mice had about 10 to 15 per cent of scar tissue formation compared with 30 to 40 per cent of scar tissue formation in those not treated.. Next, the researchers conducted disuse experiments to find out if losartan, in addition to improving muscle regeneration, might have even broader clinical applications in the protection against immobilization atrophy.. Again, using 21-month-old mice, half treated with losartan and half not, the team this time clipped the hind right ...
Apoptosis, Stem Cells, and Tissue Regeneration | Science Signaling
Most metazoans have at least some ability to regenerate damaged cells and tissues, although the regenerative capacity varies depending on the species, organ, or developmental stage. Cell replacement and regeneration occur in two contexts: renewal of spent cells during tissue homeostasis (homeostatic growth), and in response to external injury, wounding, or amputation (epimorphic regeneration). Model organisms that display remarkable regenerative capacity include amphibians, planarians, Hydra, and the vertebrate liver. In addition, several mammalian organs, including the skin, gut, kidney, muscle, and even the human nervous system, have some ability to replace spent or damaged cells. Although the regenerative response is complex, it typically involves the induction of new cell proliferation through formation of a blastema, followed by cell specification, differentiation, and patterning. Stem cells and undifferentiated progenitor cells play an important role in both tissue homeostasis and tissue ...
Prostate Cells With Regenerative Capability Uncovered by Single-Cell Transcriptomics | GenomeWeb
Using single-cell RNA sequencing, researchers identified cells in mouse and human prostate tissues that appear to help regrow the gland after prostate cancer treatment.
Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart - Dipòsit Digital de Documents de...
After myocardial infarction in the mammalian heart, millions of cardiomyocytes are lost and replaced by fibrotic scar tissue. While fibrosis is persistent in adult mammals, there are some vertebrates, including zebrafish, with the capacity for regeneration. This process does not occur in the absence of fibrosis. Here we studied subpopulations of collagen-producing cells and analyzed their fate after complete regeneration of the zebrafish myocardium. Our data show that fibroblasts persisted in the regenerated heart but shut down the profibrotic program. While fibrosis could be considered as detrimental to the regeneration process, our study reveals a positive effect on cardiomyocyte proliferation. Accordingly, a fibrotic response can be beneficial for heart regeneration. In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) proteins accumulate at the injury site. However,
ECM remodeling is a critical step in development, wound healing and regeneration (31, 38, 40, 41, 60). The present study characterized the ECM composition and its changes during zebrafish regeneration. We have developed a decellularization protocol for zebrafish ventricles that results in ECM enrichment, as well as facilitating the analysis of the proteomic profile of the zebrafish ventricle ECM. Moreover, we have analyzed the ECM changes during heart regeneration and assessed the stiffness of the ECM at different time points of this process. Altogether, the results from our studies should help better understanding the role of the ECM in zebrafish heart regeneration.. The ECM composition has not been fully studied and described in the specific contexts of the zebrafish heart and cardiac regeneration. Few are the studies done to analyze the ECM in the zebrafish heart. The proteome of different zebrafish organs, including the heart, were analyzed by Abramsson and colleagues and only 4 collagen ...
ZFIN Publication: Saera-Vila et al., 2016
Fibroblast growth factors (Fgfs) regulate critical biological processes such as embryonic development, tissue homeostais, wound healing, and tissue regeneration. In zebrafish, Fgf signaling plays an important role in the regeneration of the spinal cord, liver, heart, fin, and photoreceptors, although its exact mechanism of action is not fully understood. Utilizing an adult zebrafish extraocular muscle (EOM) regeneration model, we demonstrate that blocking Fgf receptor function using either a chemical inhibitor (SU5402) or a dominant-negative transgenic construct (dnFGFR1a:EGFP) impairs muscle regeneration. Adult zebrafish EOMs regenerate through a myocyte dedifferentiation process, which involves a muscle-to-mesenchyme transition and cell cycle reentry by differentiated myocytes. Blocking Fgf signaling reduced cell proliferation and active caspase 3 levels in the regenerating muscle with no detectable levels of apoptosis, supporting the hypothesis that Fgf signaling is involved in the early ...
Limb Regeneration - PubMed
Limb regeneration is observed in certain members of the animal phyla. Some animals keep this ability during their entire life while others lose it at some time during development. How do animals regenerate limbs? Is it possible to find unifying, conserved mechanisms of limb regeneration or have diff …
NIH award supports tissue regeneration research
The director of the National Institutes of Health, Francis S. Collins, has announced that Pak Kin Wong, UA professor of aerospace and mechanical engineering and a BIO5 Institute member, has won a $1.5 million NIH Directors New Innovator Award.
A dual epimorphic and compensatory mode of heart regeneration in zebrafish
Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodete …
Welsh Government Regeneration Framework
2. On the 17th December 2012, I reported to Cabinet the release of the consultation document Vibrant and Viable Places - A New Regeneration Framework. That report also recommended a response to that consultation (Cabinet Minute C1949 refers). 3. That report sets the context for current and future Welsh Government area based programmes with regeneration implications and that context is not repeated here. However, particularly relevant is the fact that the Barry Regeneration Area programme was launched by the Welsh Government in March 2010. A total of £9.8m of Welsh Government investment was allocated to the programme, which was initially intended to run for three years (April 2010 - March 2013 inclusive). However, following the spending review by the United Kingdom Government, this allocation was re-profiled over four years. Cabinet considered an update report on the Barry Regeneration Area Programme and the Welsh Governments Ministerial review of approaches to regeneration on 23rd July 2012 ...
During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian central nervous system (CNS) is limited, in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing CNS regeneration. Here, we performed one of the first miRNome-wide functional miRNA screens to identify microRNAs (miRNAs) with robust effects on axon growth. High-content screening identified miR-135a and miR-135b as potent stimulators of axon growth and cortical neuron migration in vitro and in vivo in male and female mice. Intriguingly, both these developmental effects of miR-135s relied, in part, on silencing of KLF4, a well-known intrinsic inhibitor of axon growth and regeneration. These results prompted us to test the effect of miR-135s on axon regeneration following injury. Our study shows that intravitreal application of miR-135s facilitates ...
Other regeneration techniques. Current concerns with the high energy/cost nature of thermal regeneration of activated ... The most common regeneration technique employed in industrial processes is thermal reactivation. The thermal regeneration ... some alternatives to thermal regeneration systems have been employed in industry. Current alternative regeneration methods are ... Per adsorption-thermal regeneration cycle between 5-15 wt% of the carbon bed is burnt off resulting in a loss of adsorptive ...
Regeneration. When a communications link must span a larger distance than existing fiber-optic technology is capable of, ... Recent advances in fiber and optical communications technology have reduced signal degradation so far that regeneration of the ...
Regeneration. Methods for regeneration of molecular sieves include pressure change (as in oxygen concentrators), heating ... Regeneration temperatures range from 175 °C to 315 °C depending on molecular sieve type. In contrast, silica gel can be ... The characteristics of these molecular sieves include fast adsorption speed, frequent regeneration ability, good crushing ... Certain beaded molecular sieves offer lower heat capacity thus less energy requirement during regeneration. ...
Regeneration. Dransfield created Jasper Square which is occupied by stores including Next, Argos and Matalan. The ...
Baptismal Regeneration, by Thomas Ross *^ Spirit Baptism: A Completed Historical Event; An Exposition and Defense of the ... Doctrine of baptismal regeneration. Baptismal regenerationalists-those Christians who believe that when one is baptized ... Opponents of baptismal regeneration understand baptism to be a means of identifying with Christ, and that when performed by ... "Regeneration." The Catholic Encyclopedia. Vol. 12. New York: Robert Appleton Company, 1911. Accessed 3 May 2013  ...
Regeneration. Regeneration of parenchyma cells, or the functional cells, of an organism. The body can make more cells to ...
Epidermal growth factor
Bone regeneration. EGF plays an enhancer role on osteogenic differentiation of dental pulp stem cells (DPSCs) because it ...
7 Regeneration. *8 Cultural references *8.1 Films. *8.2 Historic sites. *8.3 Literature ...
Regeneration. By the mid-20th century, most of the Jewish community had left the area and since the 1970s, a Bangladeshi ... The Spitalfields regeneration programme that ended in 2005, resulted in two new public spaces - Bishops Square and Crispin ...
Canadian War Museum
Regeneration Hall. This narrow, soaring hall with angled walls and a narrow triangular window that frames the Peace Tower ... "Canadian War Museum: What's On - Regeneration Hall". Canadian War Museum. 29 October 2009. Retrieved 15 July 2010.. ... "Regeneration". Globe and Mail. Retrieved 18 March 2015.. *^ "Canadian War Museum (CWM) 2010-2011 Information Sheet For tour ... while a partially grass-covered roof is consistent with the Museum's theme of regeneration and its environmentally friendly ...
Regeneration. The demolition of the Longbridge plant left behind a large amount of disused brownfield land. The site was ... bought by regeneration firm St. Modwen Properties. A shopping complex was constructed along with many new homes and a ...
Regeneration. All cnidarians can regenerate, allowing them to recover from injury and to reproduce asexually. Medusae ...
... West Strategic Regeneration Framework and Action Plan (PDF), Salford City Council, December 2006, retrieved 11 November ... Following the demise of local manufacturing industries, a 1960s regeneration project saw the construction of over 30 tower ... although there are regeneration schemes to reverse its fortunes. Many of the high-rise housing blocks from the 1960s and ...
Regeneration. In order for an injury to be healed by regeneration, the cell type that was destroyed must be able to ... Regeneration phase. In the Regeneration phase, blood vessels are repaired and new cells form in the damaged site similar ... After regeneration is complete, the damage is undetectable, even microscopically. Healing must happen by repair in the case of ... The replacement can happen in two ways: by regeneration in which the necrotic cells are replaced by new cells that form similar ...
Autotomy and tissue regeneration. All studied species of spiny mice, Acomys kempi, A. percivali, A. cahirinus, A. ... It is believed that the corresponding regeneration genes could also function in humans. ... a team from the University of Kentucky described the role of macrophages in epimorphic regeneration. The subtype of ... "Skin shedding and tissue regeneration in African spiny mice (Acomys)". Nature. 489 (7417): 561-565. doi:10.1038/nature11499. ...
Regeneration. Main article: Glan Llyn. A £115m renewal project called Glan Llyn, led by St. Modwen Properties PLC, is ...
Regeneration. The feature of the salamander that attracts most attention is its healing ability: the axolotl does not heal by ... Roy, S; Gatien, S (November 2008). "Regeneration in axolotls: a model to aim for!". Experimental Gerontology. 43 (11): 968-73. ... It revealed species-specific genetic pathways that may be responsible for limb regeneration. Although the axolotl genome is ... Identification of Genes Involved in Limb Regeneration in the Axolotl Ambystoma mexicanum ...
Regeneration. Throughout the late 1980s and early 1990s, the town invested heavily in purchasing property along the ...
Regeneration. Regeneration indicates the ability to regrow a missing part. This is very prevalent amongst plants, ... Nacu E., Tanaka E.M. (2011). "Limb Regeneration: A New Development?". Annual Review of Cell and Developmental Biology. 27: 409- ... Also popular for some purposes have been sea urchins and ascidians. For studies of regeneration urodele amphibians such ... Reddien P.W., Alvarado A.S. (2004). "Fundamentals of planarian regeneration". Annual Review of Cell and Developmental Biology. ...
Regeneration. As of November 2012[update], £3 million has been spent on the regeneration of the Strand, which has seen ... "Strand set for 3 million regeneration plan". The Devon Week. 2 September 2009. Archived from the original on 30 August 2011. ...
Regeneration. Similar to other CNS tracts, the optic has very limited regenerative potential after injury. However, some ... are incapable of regeneration, and, hence, optic nerve damage produces irreversible blindness. The fibers from the retina run ...
... frequently undergoes asexual reproduction by fission of the disk with subsequent regeneration of the arms. In both summer and ...
Regeneration of ion exchangers. High-quality hydrochloric acid is used in the regeneration of ion exchange resins. Cation ... By recuperation of the spent acid, a closed acid loop is established. The iron(III) oxide by-product of the regeneration ... The most common regeneration process is the pyrohydrolysis process, applying the following formula: ... The steel pickling industry has developed hydrochloric acid regeneration processes, such as the spray roaster or the fluidized ...
2.1 Early 2000s regeneration. *2.2 Workington Stadium plans. *2.3 Cloffocks Field development ...
Fry toured the U.S. in the summer of 2008 with the Regeneration Tour 2008, a show that also featured the Human League as the ... Fry and Palmer (as ABC) toured the U.S. as part of the 2009 'Regeneration Tour', which also featured Terri Nunn of Berlin, Wang ... "Regeneration". Archived from the original on 7 October 2011. Retrieved 3 March 2016. "Credits". AllMusic. Retrieved 3 March ...
The Intermediate Sex
During the time they served together, the men were friends, and Pat Barker's novel Regeneration is a fictionalization of their ... ISBN 978-0-7391-7152-3. Barker, Pat (1992). Regeneration. New York, United States: Dutton. pp. 53-4. ISBN 0525934278. The ...
University and College Union
"Dr Camila Bassi , Staff , Regeneration , Planning, Regeneration and Housing , Sheffield Hallam University". Shu.ac.uk. Archived ...
However, regeneration has attracted the most attention. Thomas Hunt Morgan was responsible for some of the first systematic ... The organism itself does not have to be completely cut into separate pieces for the regeneration phenomenon to be witnessed. In ... "Regeneration in S. mediterranea". Retrieved 2014-03-31. Kenk, R., 1972. Freshwater planarians (Turbellarians) of North America ... In asexual reproduction, the planarian detaches its tail end and each half regrows the lost parts by regeneration, allowing ...
April 2017). "Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space ... Sluys R, Stocchino GA (August 2017). "Bipolarity in planarians is not induced by space travel". Regeneration. 4 (4): 153-155. ... travel". Regeneration. 4 (2): 85-102. doi:10.1002/reg2.79. PMC 5469732. PMID 28616247. ...
Stocum, David L. (2017). "Mechanisms of urodele limb regeneration". Regeneration. 4 (4): 159-200. doi:10.1002/reg2.92. ISSN ... and regeneration proceeded.19 Similar studies have shown similar results in mouse digit tip regeneration. The Notch1  ... A strong example of this is lens regeneration  in the newt. Across various vertebrate models that have been used to study ... In the context of regeneration, this environmental cue is damage or injury to a limb. Cell plasticity is closely related to ...
Harnessing developmental processes for vascular engineering and regeneration | Development
Harnessing developmental processes for vascular engineering and regeneration Message Subject (Your Name) has sent you a message ... The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms ... Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond ... angiogenesis by recreating the embryonic vascular microenvironment using biomaterials for vascular engineering and regeneration ...
Development of a Device-Assisted Nerve-Regeneration Procedure in Disruptive Lesions of the Brachial Plexus. - PubMed - NCBI
Regeneration (biology) - Wikipedia
Regeneration among hydra occurs as foot regeneration arising from the basal part of the body, and head regeneration, arising ... micro RNA organ regeneration, teeth physiological teeth regeneration, and reparative skin regeneration. Rhodopsin ... A well-documented example is regeneration of the digit tip distal to the nail bed. Reparative regeneration has also been ... Regeneration in hydra has been defined as morphallaxis, the process where regeneration results from remodeling of existing ...
Retinal regeneration - Wikipedia
The two most well-studied mechanisms of retinal regeneration are cell-mediated regeneration and cellular transplantation. ... Retinal regeneration refers to the restoration of vision in vertebrates that have suffered retinal lesions or retinal ... Retinal regeneration in zebrafish is mediated by Muller glia, which dedifferentiate into stem-like cells and proliferate into ... While Muller glia division is responsible for the regeneration of the retina in all cases of retinal damage, the case of ...
Regeneration | AMNH
Balancing regeneration and cancer | Nature
Studying its role in regeneration of the blood, pancreas and brain, the three groups separately found that p16INK4a is not only ... Tissue repair and regeneration are essential for longevity in complex animals, and often depend on the proliferation of ... Recovery from the toxin requires β-cell proliferation and the regeneration of functional islets. After toxin treatment, the p16 ... Although it ensures tissue repair and regeneration, it also puts tissues at risk of hyperproliferative diseases, the most ...
... Edited by: Xiaobing Fu. In humans, the biological response and outcome to wounding falls primarily into ... Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells ... Fortunately, progress in regenerative medicine brings hope for fully regeneration of organ and tissue after trauma injury. As ... Its clinical application focuses on the repair, replacement, and regeneration of cells, tissues, and organs by approaches ...
Regeneration | CMAJ
Gods Role in Regeneration. 03/23/2015 12:03:17 PM PDT · by redleghunter · 9 replies Grace to You ^ , January 27, 2013 , John ... A Biblical Refutation of Baptismal Regeneration Baptismal Regeneration is the teaching which says that water baptism is an ... Regeneration in the ESV Study Bible. 10/23/2008 11:18:36 AM PDT · by Gamecock · 47 replies · 575+ views Monergism ^ ... Missing parts? Salamander regeneration secret revealed. 05/20/2013 7:20:34 PM PDT · by Redcitizen · 53 replies Live science ^ ...
8WC00 - Regeneration
... Contents The various tissues of the human body show an intriguing adaptive capacity. Their composition, ... Growth, differentiation, and regeneration of specific tissues and during different stages of development *Foetal development, ... Why is cell therapy for cardiac regeneration still a myth? A 3D cardiac hydrogel model system to unravel the myth ... Maintenance and regeneration of various tissues (blood, skin, gut, muscle, bone, nerve) ...
CUCM Certificate Regeneration/Renewal Process - Cisco
Upon regeneration, the IPsec certificate automatically uploads itself to ipsec-trust.. set cert regen ipsec. Regenerate Tomcat ... Upon regeneration, the Tomcat certificate automatically uploads itself to tomcat-trust.. set cert regen tomcat. Regenerate TVS ... Caution: Regenerations of certificates triggers an automatic update of the ITL files within the cluster, which triggers a ... Proceed with regeneration (yes,no)? yes. Successfully Regenerated Certificate for CAPF.. You must restart services related to ...
Letter from Santiago: Regeneration Now
... under the banner of Regeneration International, came together in the ... But as those of us in the Regeneration Movement understand, heart and mind, weve still got time to turn things around. But the ... Ronnie Cummins is a founding steering committee member of Regeneration International and co-founder and international director ... As we affirmed in our Regeneration International General Assembly meeting on December 10 in Santiago: ...
The Crisis: Regeneration or Degeneration?
... speaking at the founding meeting of Regeneration International, La Fortuna de San Carlos, Costa Rica, June 8, 2015 When ... Regeneration International-next steps. With a formal steering committee composed of Vandana Shiva (India writer and activist) ... In order to survive we must all become evangelists of Regeneration. We must explain the basic principles and practices of soil ... Ronnie Cummins is international director of the Organic Consumers Association and a member of the Regeneration International ...
The Regeneration Trilogy
... :. Regeneration. The Eye in the Door. The Ghost Road ... Regeneration, The Eye in the Door and The Ghost Road follow the stories of these men until the last months of the war. Widely ... Thirty-five years later, she has published sixteen novels, including her masterful Regeneration Trilogy, been made a CBE for ... acclaimed and admired, Pat Barkers Regeneration trilogy paints with moving detail the far-reaching consequences of a conflict ...
Skin regeneration with insights : Nature News & Comment
Skin regeneration with insights. A feat in stem-cell therapy highlights what can be achieved when basic and clinical research ... normal regeneration of the epidermis is directed by only a few stem-cell clones that can self-renew. ... watched pioneers in skin regeneration learn to grow small sheets of skin from cells taken from burns patients, and to use them ...
Radical Tails: Antioxidants Can Prevent Regeneration | HuffPost
The ultimate hope is that by identifying the specific mechanisms of injury response and regeneration, one might be able to ... On the other hand, the antioxidant scavenger that soaks up oxidants being produced did not permit regeneration while it was ... The exact molecular targets of the oxidant hydrogen peroxide that enable regeneration remain unknown, but some of the data in ... This does suggest that there may be some key similarities between the tadpole regeneration pathways and those found in humans. ...
The Regeneration Trilogy - Pat Barker - Google Books
The Regeneration Trilogy: Regeneration; the Eye in the Door; the Ghost Road. Pat Barker. No preview available - 2014. ... Regeneration The forthcoming anniversary of the Great War should provide some motivation for readers to revisit, or discover ... Pat Barkers most recent novel is Another World (FSG, 1999). She is also the author of the highly acclaimed Regeneration ... trilogy: Regeneration; The Eye in the Door, winner of the 1993 Guardian Fiction Prize; and The Ghost Road, winner of the 1996 ...
Universal Soldier: Regeneration Pictures - Rotten Tomatoes
Civil rights and regeneration - CSMonitor.com
Reformation and regeneration need to occur within each life as it is touched by the Christ, by Gods healing, saving power. ... Our individual regeneration, our own recognition of Gods government and our yielding to it, is the basis for progressive ... Its clear that profound, lasting change for the better can only grow out of deep moral and spiritual regeneration. ...
Assessing regeneration potential | Treesearch
... the first thing to do is assess the regeneration potential. Regeneration potential is the likelihood of being successful in ... When a regeneration harvest cut is planned for even-aged stands or it is time to make another cut in uneven-aged stands, ... Assessing regeneration potential. In: Hutchinson, Jay G., ed. Central hardwood notes. St. Paul, MN.: U.S. Dept. of Agriculture ... You need an assessment to be reasonably sure that regeneration and management objectives can be met. In even-aged stands, an ...
Regeneration Daily Lesson Calendar
University Urbanism: Campus Development and Urban Regeneration
Covers engaging with and contributing to wider urban regeneration goals, positioning universities as anchor institutions. ... It will look at how to engage with and contribute to wider urban regeneration goals, positioning universities as anchor ... recognise key issues in university development and contextualise these within a wider discussion around urban regeneration ... This one-day course will examine specific industry challenges in university-led urban regeneration. ...
How sharks could aid human tooth regeneration
But a new study may bring us a step closer to human tooth regeneration, by shedding light on how sharks regrow their pearly ... In sharks, these tooth-making genes are likely to have evolved over time to trigger a regeneration process when a tooth is lost ... These findings, however, indicate that it may one day be possible to trigger tooth regeneration in humans. ... How sharks could aid human tooth regeneration. Written by Honor Whiteman on February 15, 2016 ...
Fujitsu Tropical Rainforest Regeneration Project - Fujitsu Italy
Fujitsu Tropical Rainforest Regeneration Project - Fujitsu China
Skeletal Muscle Regeneration in the Mouse | SpringerLink
This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic ... Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory ... This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic ... Myogenic Progenitors from Mouse Pluripotent Stem Cells for Muscle Regeneration Alessandro Magli, Tania Incitti, Rita C. R. ...
Regeneration in Digital Contexts: Early Black Film
Contest Inspires Limb Regeneration Research - Scientific American
Contest Inspires Limb Regeneration Research. Genome-sequencing contest renews regeneration research. *By Christine Soares on ... "Obviously the goal is to understand which genes are turned on during regeneration and to understand more of the process," ... Sequencing this material revealed that genes seemingly involved in triggering the cellular regeneration program are some of the ... Gardiner thinks that the project will jump-start a new molecular era in salamander regeneration research, which he admits had ...
Wellbeing Regeneration Llanelli Fundraising | Easyfundraising
Raise free funds for Wellbeing Regeneration Llanelli today by shopping online via Easyfundraising. Click now to shop at no ... Wellbeing Regeneration is a not-for-profit social business and provides vital but basic health and wellbeing services that ... Raise donations for Wellbeing Regeneration Llanelli whenever you shop online. Turn your everyday online shopping into FREE ...
TissueBaptismal RegenerationRegenerativeHumans2017TransplantationSkeletal muscleCardiac regenerationTissuesBarkerTrilogyCity centre regenerationZebrafishEngineering and RegenerationInflammationNerveUrbanOlfactory SystemTail regenerationContentSpeciesSalamanderStem cellSustainabilityMainCitationParticulateMolecularVertebratesDevelopmentCellularPathwaysWound repairProcessLesionsLiverCatalystAdultStrategiesScientistsApproachesOrgansFunctionalResearchersTailsPreservationStudyProjects
- The formation of vasculature is essential for tissue maintenance and regeneration. (biologists.org)
- Echinoderms (such as the sea star), crayfish, many reptiles, and amphibians exhibit remarkable examples of tissue regeneration. (wikipedia.org)
-  Dedifferentiation of cells means that they lose their tissue-specific characteristics as tissues remodel during the regeneration process. (wikipedia.org)
- Tissue repair and regeneration are essential for longevity in complex animals, and often depend on the proliferation of unspecialized cells known as stem or progenitor cells. (nature.com)
- Although it ensures tissue repair and regeneration, it also puts tissues at risk of hyperproliferative diseases, the most deadly of which is cancer. (nature.com)
- In humans, the biological response and outcome to wounding falls primarily into two categories: tissue regeneration and wound repair. (biomedcentral.com)
- Fortunately, progress in regenerative medicine brings hope for fully regeneration of organ and tissue after trauma injury. (biomedcentral.com)
- As an emerging interdisciplinary field of research, its clinical application focuses on the repair, replacement and regeneration of cells, tissues, or organs by approaches including cell reprogramming, stem cell transplantation, tissue engineering, activating factors and clone treatment. (biomedcentral.com)
- This thematic series introduces the recent development of regenerative medicine in basic and clinical research in China and other countries, and some innovative studies in promoting wound healing and tissue regeneration. (biomedcentral.com)
- However, by 1 wk of life, the potential for heart regeneration is lost in mice and is replaced by a fibrotic response that generates scar tissue, which impedes regeneration and impairs cardiac contractility ( 13 ). (pnas.org)
- This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. (springer.com)
- There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. (springer.com)
- His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks - as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded. (springer.com)
- with true "wound healing" by regeneration of fully differentiated, functional tissue. (theregister.co.uk)
- Mathematical modeling identifies a robust mechanism for coordinating regeneration across a large tissue. (sciencemag.org)
- In a mouse study designed to understand how chronic inflammation in sinusitis damages the sense of smell, scientists at Johns Hopkins say they were surprised to learn that the regeneration of olfactory tissue requires some of the same inflammatory processes and chemicals that create injury and loss of smell in the first place. (eurekalert.org)
- The kind of inflammation associated with immune system reactions to fight infection or injury appears to be part of a single system linked to tissue regeneration, so that normal healing of the olfactory system can't happen without it," says Andrew Lane, M.D. , professor of otolaryngology-head and neck surgery at the Johns Hopkins University School of Medicine. (eurekalert.org)
- Compared to mice not given the steroids, mice given steroids had 45 percent fewer stem cells proliferating to replace the damaged ones in the tissue, suggesting that suppressing inflammation slowed olfactory stem cell regeneration. (eurekalert.org)
- The grafts remained intact 6 months after transplantation, and boosted the regeneration of TMJ tissue more effectively than other graft designs that could only repair bone. (news-medical.net)
- Chen, D., (2020) Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration. (news-medical.net)
- The Musculoskeletal Tissue Regeneration (MoTR) Laboratory is a part of the Rutgers University Department of Biomedical Engineering . (rutgers.edu)
- We primarily focus on the repair and regeneration of tissue, mainly musculoskeletal tissue, through the use of tissue engineering techniques. (rutgers.edu)
- The composite material can be used as a scaffold for supporting chondrocytes or progenitor cells differentiating thereto and is useful for an implant for cartilage tissue regeneration. (freepatentsonline.com)
- 7. An implant for use in cartilage tissue regeneration, comprising chondrocytes or progenitor cells differentiating thereto and a scaffold which comprises the material according to any one of claims 1 to 4. (freepatentsonline.com)
- 0003] The present invention relates generally to tissue regeneration, particularly cartilage tissue regeneration for repairing cartilage lesion caused by, for example, accidents or diseases, including osteoarthritis. (freepatentsonline.com)
- This review assesses the tissue culture derived data with a view to understanding factors which may control the regeneration of mature skeletal muscle in vivo. (nih.gov)
- A Biblical Refutation of Baptismal Regeneration Baptismal Regeneration is the teaching which says that water baptism is an essential requirement for salvation. (freerepublic.com)
- BAPTISMAL REGENERATION is the unbiblical teaching that a person MUST be water baptized in order to go to Heaven. (jesus-is-savior.com)
- Baptismal Regeneration is a lie of the Devil. (jesus-is-savior.com)
- The ultimate hope is that by identifying the specific mechanisms of injury response and regeneration, one might be able to activate similar repair processes in humans, who lack the extraordinary regenerative capacity of amphibians. (huffingtonpost.com)
- The exact molecular targets of the oxidant hydrogen peroxide that enable regeneration remain unknown, but some of the data in the paper point to the Wnt protein pathway as a potential oxidant-sensitive regenerative signal in the tadpole tail. (huffingtonpost.com)
- Nevertheless, this work is an important milestone in understanding the role of oxidants as promoters of regeneration, and it is very likely that at least some similar pro-regenerative role of oxidants may also be present in human tissues. (huffingtonpost.com)
- Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. (elsevier.com)
- Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research in skeletal muscle growth, damage, repair, degeneration, and regenerative therapy in the mouse model system. (springer.com)
-  Every species is capable of regeneration, from bacteria to humans. (wikipedia.org)
- Forest regeneration, following such events as forest clearing by humans or as part of a natural process, results from interactions among diverse groups of organisms and the environment. (britannica.com)
- This does suggest that there may be some key similarities between the tadpole regeneration pathways and those found in humans. (huffingtonpost.com)
- These findings, however, indicate that it may one day be possible to trigger tooth regeneration in humans. (medicalnewstoday.com)
- The grace of regeneration is the power of God that grants humans the ability to exercise faith and new inclinations towards God. (thegospelcoalition.org)
- This shows that fibrinogen deposits are extremely important and directly impact regeneration in both mice and humans," Luyendyk said. (eurekalert.org)
- The Regeneration exhibition runs until the 28th of April 2017 at the Transnatural workspace. (mediamatic.net)
- The two most well-studied mechanisms of retinal regeneration are cell-mediated regeneration and cellular transplantation. (wikipedia.org)
- Other approaches to retinal regeneration involve cellular transplantation treatments. (wikipedia.org)
- In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. (elsevier.com)
- Dr. Mark Flood, Chief Surgeon and Medical Director of Celling Treatment Centers in Austin, TX, is one of the very first physicians to use stem cell transplantation for disc regeneration. (prweb.com)
- This volume focuses on the cell biology and physiology of skeletal muscle regeneration. (springer.com)
- This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an investigator to develop and implement a research study on skeletal muscle regeneration. (springer.com)
- Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing the progenitor cells of skeletal muscle, and quantifying overall muscle function. (springer.com)
- Conversely, forced expression of a constitutively active form of Yap in the adult heart stimulates cardiac regeneration and improves contractility after myocardial infarction. (pnas.org)
- These findings identify Yap as an important regulator of cardiac regeneration and provide an experimental entry point to enhance this process. (pnas.org)
- These somatic stem cells have been studied for use in cardiac regeneration. (mdpi.com)
- Its clinical application focuses on the repair, replacement, and regeneration of cells, tissues, and organs by approaches includin. (biomedcentral.com)
- One has to bear in mind that this work was performed in tadpoles and may not be necessarily fully applicable to the human setting, but Wnt is a key regulator of stem cell renewal, differentiation and regeneration in human tissues. (huffingtonpost.com)
- The extent of neonatal heart regeneration in mice is comparable to that in zebrafish, which can regenerate diverse tissues ( 15 ⇓ - 17 ). (pnas.org)
- Regeneration study guide contains a biography of Pat Barker, literature essays, quiz questions, major themes, characters, and a full summary and analysis. (gradesaver.com)
- These papers were written primarily by students and provide critical analysis of Regeneration, the first novel in the Regeneration Trilogy, by Pat Barker. (gradesaver.com)
- Widely acclaimed and admired, Pat Barker's Regeneration trilogy paints with moving detail the far-reaching consequences of a conflict which decimated a generation. (penguin.co.uk)
- Thirty-five years later, she has published sixteen novels, including her masterful Regeneration Trilogy, been made a CBE for services to literature, and won the UK's highest literary honour, the Booker Prize. (penguin.co.uk)
- Regeneration The forthcoming anniversary of the Great War should provide some motivation for readers to revisit, or discover this trilogy from the nineties. (google.com)
- Regeneration is the first novel in the Regeneration Trilogy. (gradesaver.com)
City centre regeneration2
- The City Council has undertaken these works to ensure traffic can still flow during these works, but the Broadmarsh area works are some of the biggest city centre regeneration works taking place in the UK. (nottinghamcity.gov.uk)
- In September 2015 we launched the City Centre Regeneration and Investment Strategy which outlines how we aim to grow and regenerate the city core and its surrounding areas to 2030. (belfastcity.gov.uk)
- Cells in the primordia of zebrafish fins, for example, express four genes from the homeobox msx family during development and regeneration. (wikipedia.org)
- This ability combined with the considerable similarity between teleost and mammalian retinal structure makes zebrafish an attractive model for the study of retinal regeneration. (wikipedia.org)
- Retinal regeneration in zebrafish is mediated by Muller glia, which dedifferentiate into stem-like cells and proliferate into neural progenitor cells in response to retinal damage. (wikipedia.org)
- Heart regeneration in zebrafish and neonatal mice is correlated with global activation of cardiomyocyte proliferation throughout the injured organ ( 13 , 18 , 19 ). (pnas.org)
- The focus of the present paper is on spinal cord regeneration in adult zebrafish. (hindawi.com)
Engineering and Regeneration1
- Specifically, we will focus on some of the recently reported approaches to stimulate therapeutic angiogenesis by recreating the embryonic vascular microenvironment using biomaterials for vascular engineering and regeneration. (biologists.org)
- But more isn't always better, and continued inflammation will eventually have the opposite effect of killing olfactory neurons and inhibiting their regeneration, resulting in the loss of smell. (eurekalert.org)
- Development of a Device-Assisted Nerve-Regeneration Procedure in Disruptive Lesions of the Brachial Plexus. (nih.gov)
- It is centered on an artificial device designed to assist nerve regeneration by providing a confined and protected environment. (nih.gov)
- Does anyone have any experience with nerve repair/ regeneration for Paralyzed diaphragm? (medhelp.org)
- May 23, 2012 - Interventions resulting in optic nerve regeneration restored some components of vision, according to the results of a mouse model study published online May 21 issue of the Proceedings of the National Academy of Sciences . (medscape.com)
- However, in the past few years there have been several demonstrations that anatomical regeneration of the optic nerve can be partially induced after injury, following stimulation with various neurotrophic and neuroprotective factors. (medscape.com)
- For the first time, Dr. Benowitz and colleagues showed that partial anatomical regeneration of the optic nerve is accompanied by partial recovery of function," Dr. Limb said. (medscape.com)
- Although untreated blind mice were equally likely to walk over either end, mice that had optic nerve regeneration in response to the interventions spent less time over the "deep" end. (medscape.com)
- By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated for the first time. (lifeboat.com)
- This TDD on urban regeneration sought to enhance city decision makers' knowledge and technical capacity to implement urban revitalization initiatives, particularly by identifying viable business models that can also maximize the government's economic and policy goals. (worldbank.org)
- and (iii) application of these concepts and skills to ongoing urban regeneration initiatives. (worldbank.org)
- The program explored Japanese, Korean, and other global examples of government strategies to spur regeneration, including cases focused on urban regeneration catalyzed by development or relocation of government assets, construction of new parks and/or civic space, and repurposing of former industrial sites. (worldbank.org)
- Site visits in Seoul, including Seoullo 7017, Dandaemung Design Plaza, Seoul City Hall, World Cup Park, and Sangam DMC, showed participants how local governments can take leadership in urban regeneration projects. (worldbank.org)
- The program was well received by clients as well as World Bank staff specializing in urban regeneration. (worldbank.org)
- This one-day course will examine specific industry challenges in university-led urban regeneration . (ucl.ac.uk)
- It will look at how to engage with and contribute to wider urban regeneration goals, positioning universities as 'anchor institutions' . (ucl.ac.uk)
- The EBRD is considering a senior loan of up to USD 80 million to support the completion of Phase I of the Abdali Urban Regeneration Project ("AURP"), a major mixed-use brownfield regeneration of the centre of Amman and currently the largest project of this kind in the SEMED region. (ebrd.com)
- The goals of the project are: to provide food, entertainment and retail space in an area where it is lacking, to support the urban regeneration of the centre of Amman, to help provide employment to the local population and to develop the building in a highly sustainable way. (ebrd.com)
- Overall, the Project will support the urban regeneration of this area of the city by helping to create a new central business district in Amman on a brownfield site, thus stimulating further investment in Amman as a new business hub in the region. (ebrd.com)
- is the masterplan developer of the Abdali Urban Regeneration project. (ebrd.com)
- SMi's Urban Regeneration Conference will provide an update on the latest UK regeneration schemes. (smi-online.co.uk)
- This event includes presentations from Urban Regeneration Companies, Regional Development Agencies, Local Authorities and the private sector, and is aimed at project managers, development officers and those involved or interested in regeneration projects across the UK. (smi-online.co.uk)
- Taking the form of a three year research-based exchange programme that started in March 2013, the project addresses and questions the (recently widely adopted) idea of citizen participation in the process of urban regeneration, through case studies in four cities: Berlin, Cairo, Istanbul and Tehran. (tu-berlin.de)
- Are you sure you want to remove Urban regeneration and economic development from your list? (openlibrary.org)
- This report examines land-use trends, policies and practices in Korea, in particular in the city of Busan, through the lens of urban regeneration and citizen participation. (oecd.org)
- Korea has benefitted from comprehensive and well-structured, hierarchical land-use planning and urban regeneration frameworks. (oecd.org)
- However, faced with a series of demographic and economic challenges, together with geographic factors and historical developments, Korea needs to re-evaluate land-use management and urban regeneration to leverage inclusive growth and boost competitiveness in Korean cities. (oecd.org)
- This report argues that involving citizens in land-use planning and urban regeneration is essential to collect better quality information as a basis for plans, decisions and outcomes. (oecd.org)
- This report is of relevant to urban planners, land use especialists, and city managers who work on urban regeneration projects and citizens' participation. (oecd.org)
- David Panos & Anja Kirschner's film, Trail of the Spider, allegorises the public-private land-grab known as 'urban regeneration' using the form of the Spaghetti Western. (metamute.org)
- The recent paper " Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration ," by Nick Love and colleagues, published online in the journal Nature Cell Biology on Jan. 13, 2013, elegantly demonstrates that reactive oxygen species (ROS), also known as oxygen radicals or oxidants, play a critical role in the regeneration of amphibian tails. (huffingtonpost.com)
- After excluding the possible confounding phenomenon that the increase in ROS was merely a bystander effect of increases in inflammatory cells, the researchers then performed a pivotal set of experiments in which they used antioxidants to see if these would affect the tail regeneration. (huffingtonpost.com)
- Regeneration main content. (amnh.org)
- Regeneration potential is the likelihood of being successful in reproducing desired species. (usda.gov)
- The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. (springer.com)
- Here we show that paired-fin regeneration after endoskeleton amputation occurs in living representatives of all major actinopterygian clades: the American paddlefish (Chondrostei), the spotted gar (Holostei), and in 2 cichlid and 1 cyprinid species (Teleostei). (pnas.org)
- The role of the catalyst in regeneration of catalytic particulate traps was found to be the oxidation of gaseous fuel species, such as carbon monoxide and hydrocarbons, in the exhaust. (sae.org)
- However, developing advanced oak regeneration on productive sites has been difficult because stand prescriptions encouraging oak regeneration are the same conditions that favor development of potentially faster growing competitor species. (usda.gov)
- SRS scientists are partnering with the North Carolina Wildlife Resources Commission and the Stevenson Land Company to initiate a regional study that focuses on the ecosystem response (regeneration of oakand other hardwood species, and plant diversity) to three recommended, but not widely tested, treatments. (fed.us)
- Now that the collaborators have sifted some of their data, the serendipitous sequencing project is yielding nuggets of information valuable to each of them, while potentially reviving the study of salamander regeneration. (scientificamerican.com)
- And after seeing what access to cheaper sequencing technology can accomplish, Gardiner thinks that the project will jump-start a new molecular era in salamander regeneration research, which he admits had reached something of an impasse using traditional biology techniques. (scientificamerican.com)
- For example, normal regeneration of the epidermis is directed by only a few stem-cell clones that can self-renew. (nature.com)
- Departments of Pediatrics and Neurosurgery, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA. (nih.gov)
- Enter the concept of regeneration , which some experts are hoping will replace sustainability as the buzzword of the future. (treehugger.com)
- Regeneration is sustainability taken a step further. (treehugger.com)
- Widespread oak decline and regeneration failure threaten the sustainability of oak forests that play important ecological and economic roles in North Carolina and elsewhere in the South. (fed.us)
- Despite the ministry that resulted from the strike, presided over by marshal Saldanha, the main person of the Regeneration was Fontes Pereira de Melo. (wikipedia.org)
- Regeneration essays are academic essays for citation. (gradesaver.com)
- Diesel particulate filter regeneration (through oxidation of the collected soot particles) is not currently possible under all engine operating conditions without additional external thermal energy. (sae.org)
- The exploitation of the autothermal properties of the reverse flow reactor has been suggested to reduce further the soot ignition temperature and hereby is studied for the periodically reversed flow regeneration of soot particulate filters, with the aid of a mathematical model for the regeneration process, validated against experimental data. (sae.org)
- Konstandopoulos, A. and Kostoglou, M., "Periodically Reversed Flow Regeneration of Diesel Particulate Traps," SAE Technical Paper 1999-01-0469, 1999, https://doi.org/10.4271/1999-01-0469 . (sae.org)
- Using a DD6V-71N coach engine and a prototype catalytic particulate trap, a trap regeneration system was developed which delivers vaporized diesel fuel to the exhaust, upstream of the catalytic particulate trap. (sae.org)
-  At its most elementary level, regeneration is mediated by the molecular processes of gene regulation . (wikipedia.org)
- Retinal regeneration refers to the restoration of vision in vertebrates that have suffered retinal lesions or retinal degeneration. (wikipedia.org)
- Salamanders and lungfishes are the only lobe-finned vertebrates where appendage regeneration after endoskeleton amputation has been demonstrated. (pnas.org)
- For more information on Regeneration, please contact our City Regeneration and Development Team. (belfastcity.gov.uk)
- Now, study leader Dr. Gareth Fraser, from the Department of Animal and Plant Sciences at the University of Sheffield in the UK, and colleagues have identified a network of genes that are responsible for tooth development and lifelong tooth regeneration in sharks. (medicalnewstoday.com)
- The dental lamina was found to drive tooth development and continuous tooth regeneration in the sharks. (medicalnewstoday.com)
- Due diligence focused on the Bank financed project i.e. the development of the Abdali Centre, although aspects of the broader Abdali regeneration scheme were considered to set the Abdali Centre Project in context. (ebrd.com)
- Myelin regeneration: a recapitulation of development? (nih.gov)
- Here we review the current evidence for the recapitulation hypothesis and discuss recent findings in the development and regeneration of myelin in the context of human neurological disease. (nih.gov)
- This review will describe how recent findings have expanded our understanding of the development, organization, and regeneration of hair follicle stem cells. (jci.org)
-   Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. (wikipedia.org)
- Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. (wikipedia.org)
- Sequencing this material revealed that genes seemingly involved in triggering the cellular regeneration program are some of the same ones active in embryonic stem cells, suggesting that the cells had reverted to a more primitive state. (scientificamerican.com)
- Several proteins and signaling pathways have been described and characterized in the process of retinal regeneration. (wikipedia.org)
-  More information on the signaling pathways involved is required before Muller glia mediated regeneration will be a viable treatment method for restoring vision in mammalian retinas. (wikipedia.org)
- We are now beginning to develop the genetic tools to examine these specific hair follicle populations in an effort to characterize their regulation and how they contribute to the pleiomorphic functions of HFSCs in hair regeneration, wound repair, and tumorigenesis. (jci.org)
- In biology , regeneration is the process of renewal, restoration, and growth that makes genomes , cells , organisms , and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. (wikipedia.org)
- The new growth of seedlings and community assembly process is known as regeneration in ecology . (wikipedia.org)
- In sharks, these tooth-making genes are likely to have evolved over time to trigger a regeneration process when a tooth is lost - a way of maintaining their hunting abilities. (medicalnewstoday.com)
- Obviously the goal is to understand which genes are turned on during regeneration and to understand more of the process," explains Zhu's boss, Tony Hunter. (scientificamerican.com)
- RegenaDISC disc regeneration therapy can thereby help to restore your disc health, slow down the degenerative process and reduce your pain so that you can get back to your normal life without having to spend several weeks recovering from surgery. (prweb.com)
- But once we figure out exactly how fibrinogen works in the regeneration process and test potential therapies in mice, it could eventually provide the proof we need to bring our work into the clinic and improve patient outcomes. (eurekalert.org)
- As its MicroTips pass over your skin, the regeneration process begins immediately, with cells responding to imperceptible microchannels by restoring volume from the inside out. (popsugar.com)
- 0005] Articular cartilage defect caused by osteoarthritis or traumatic lesions is a major problem in orthopedic surgery due to the limited capacity for repair and self-regeneration. (freepatentsonline.com)
- We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration," said James Luyendyk, a professor of pathobiology in the College of Veterinary Medicine. (eurekalert.org)
- The historic environment can be a successful catalyst for regeneration, delivering projects that can provide homes, jobs and improved public realm. (rtpi.org.uk)
- The numerical results confirm the capability of the new technique to effectively succeed where conventional regeneration fails, extending thus the operating limits of already practiced regeneration techniques (thermal or catalyst-assisted) and setting the stage for the construction of an industrial prototype. (sae.org)
- The adult mammalian heart has limited potential for regeneration. (pnas.org)
- The adult mammalian heart has limited potential for regeneration or repair ( 1 ), and thus the loss of cardiomyocytes during injury and disease results in diminished pump function and heart failure, a primary cause of human morbidity and mortality. (pnas.org)
- Thus, beside self-replication of preexisting insulin-producing cells, several potential cell sources in the adult pancreas were suggested to contribute to beta-cell regeneration, including acinar, intraislet, and duct epithelia. (hindawi.com)
- However, regeneration in the adult endocrine pancreas is still under controversial debate. (hindawi.com)
- The film, a self-described 'Western made in London and Essex', deploys the vanishing frontier motif and subversive Western genre tropes in complex yet unambiguous terms to examine contemporary 'regeneration' strategies in East London. (metamute.org)
- Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. (hindawi.com)
- Moreover, the study of animal models of pancreas injury revealed that the pancreas has the propensity to undergo regeneration and opened new avenues to develop novel therapeutic approaches for the treatment of diabetes. (hindawi.com)
-  The regeneration of organs is a common and widespread adaptive capability among metazoan creatures. (wikipedia.org)
- Recovery from the toxin requires β-cell proliferation and the regeneration of functional islets. (nature.com)
- In another intriguing set of experiments, the researchers treated the tadpoles with these agents immediately after the injury and then withdrew them after three days, to see if the regeneration would set in after their removal. (huffingtonpost.com)
- salamanders and newts ), an order of tailed amphibians , is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
- As a young scientist at Harvard Medical School in Boston, Massachusetts, in the 1980s, Michele De Luca - the lead author of the new study - watched pioneers in skin regeneration learn to grow small sheets of skin from cells taken from burns patients, and to use them in grafts. (nature.com)
- Planarians are much simpler making them ideal model systems to study regeneration. (eurekalert.org)
- But a new study may bring us a step closer to human tooth regeneration, by shedding light on how sharks regrow their pearly whites. (medicalnewstoday.com)
- This film will be screened in support of the Regeneration in Digital Contexts: Early Black Film Conference which convenes an interdisciplinary group of scholars and moving image archivists to discuss the new methodologies and questions emerging through recent scholarship in early black film, and to consider how we render a film as an object of study in transformative digital environments. (indiana.edu)
- We are already involved in many regeneration projects, working in partnership with others to develop local communities and create job and business opportunities. (belfastcity.gov.uk)