A group of phenyl benzopyrans named for having structures like FLAVONES.
5,7,4'-trihydroxy-flavone, one of the FLAVONES.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.
A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).
A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.
Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.
A group of FLAVONOLS based on kaempferol. They are derived from naringenin and can be hydroxylated to QUERCETIN or reduced to leucopelargonidin.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
A group of 4-keto-FLAVONOIDS.
A plant genus of the family LAMIACEAE. The common names of beebalm or lemonbalm are also used for MONARDA.
Application of pharmaceutically active agents on the tissues of the EYE.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A group of FLAVONOIDS characterized with a 4-ketone.
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Energy transmitted from the sun in the form of electromagnetic radiation.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.
A plant genus of the family OLEACEAE. Oleuropein, a phenolic secoiridoid glycoside, is found in the leaves.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
A plant genus of subsucculent annual or perennial plants in the family BALSAMINACEAE, order Geraniales.
A cell line derived from cultured tumor cells.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
The above-ground plant without the roots.
5,7,3',4'-tetrahydroxy-flavone, one of the FLAVONES.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Substances that reduce or suppress INFLAMMATION.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Cyclohexane ring substituted by one or more ketones in any position.
A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
A species of gram-negative, aerobic bacteria that causes formation of root nodules on some, but not all, types of sweet clover, MEDICAGO SATIVA, and fenugreek.
A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
Dimers (homo and hetero) of FLAVONOIDS.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A family of diphenylenemethane derivatives.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Use of plants or herbs to treat diseases or to alleviate pain.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
The reproductive organs of plants.
DNA of kinetoplasts which are specialized MITOCHONDRIA of trypanosomes and related parasitic protozoa within the order KINETOPLASTIDA. Kinetoplast DNA consists of a complex network of numerous catenated rings of two classes; the first being a large number of small DNA duplex rings, called minicircles, approximately 2000 base pairs in length, and the second being several dozen much larger rings, called maxicircles, approximately 37 kb in length.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely transforming retrovirus AKT8. v-akt protein is the viral homologue of PROTO-ONCOGENE PROTEINS C-AKT.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A large class of organic compounds having more than one PHENOL group.
The cellular signaling system that halts the progression of cells through MITOSIS or MEIOSIS if a defect that will affect CHROMOSOME SEGREGATION is detected.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Uptake of substances through the lining of the INTESTINES.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
Tumors or cancer of the PROSTATE.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Compounds that inhibit the activity of DNA TOPOISOMERASE I.
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Examinations used to diagnose and treat heart conditions.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Endothelial cells that line venous vessels of the UMBILICAL CORD.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
The action of a drug in promoting or enhancing the effectiveness of another drug.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Regular course of eating and drinking adopted by a person or animal.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Established cell cultures that have the potential to propagate indefinitely.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tumors or cancer of the SKIN.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The giving of drugs, chemicals, or other substances by mouth.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Tumors or cancer of the COLON.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Glycoproteins found on the membrane or surface of cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The rate dynamics in chemical or physical systems.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Tumors or cancer of the LUNG.
Luteolin reduces IL-6 production in some neurons. Jones SA, Scheller J, Rose-John S (2011). "Therapeutic strategies for the ... Jang S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and ...
Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N-terminal kinase phosphorylation and activation of ...
Such solutions also reduce edema and serum cholesterol levels and, because they contain the glycosides quercetin and luteolin, ... water-based solutions of the flowers reduce edema and serum cholesterol levels (Jiu 1966). [The tree...] also acts as a ... which has yellow flowers and a reduced form of the claw. The Aztecs and others have used solutions containing the tree's ... diuretic (due to the glycosides quercetin and luteolin) and, when ingested regularly as a decocted beverage, is most likely ...
Luteolin, a type of flavonoid found mostly in leaves, and their synthetic derivatives are potential inhibitors of aldose ... The excess sugar within the lens is reduced by aldose reductase to its alcohol, but the lens capsule is relatively impermeable ... 3 (6). Sebastian J (2016). "Structure-Activity Relationship Study Reveals Benzazepine Derivatives of Luteolin as New Aldose ... thereby reducing the copious mucous secretion associated with these. Várkonyi T, Kempler P (February 2008). "Diabetic ...
Ferric reducing ability of plasma(英语:Ferric reducing ability of plasma) ... The flavonoid luteolin inhibits niacin-induced flush. Brit J Pharmacol. 2008, 153 (7): 1382-87. PMC 2437911. PMID 18223672. doi ... Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J. ... Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects ...
The leghemoglobin reduces the amount of free oxygen present. Oxygen disrupts the function of the nitrogenase enzyme in the ... Hartwig UA, Maxwell CA, Joseph CM, Phillips DA (January 1990). "Chrysoeriol and Luteolin Released from Alfalfa Seeds Induce nod ... These techniques reduce the need for inorganic nitrogenous fertilizers. Symbiosis between S. meliloti and its legume hosts ... Peters NK, Frost JW, Long SR (August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti nodulation ...
Such initiatives may enable farmers to reduce nitrogen fertilizer use and runoff of fertilizer into local water supplies. Her ... Her group discovered that a flavone (luteolin) derived from alfalfa seed extracts is necessary for activation of nodulation ... Peters, NK; Frost, JW; Long, SR (29 August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti ... Peters, NK; Frost, JW; Long, SR (29 August 1986). "A plant flavone, luteolin, induces expression of Rhizobium meliloti ...
Lactating animals may cease or have reduced milk production; pregnant animals may abort. Lesions on udders are often apparent. ... luteolin) Phenolic acids (e.g. chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, p-hydroxybenzoic acid, vanillic ... Animals typically seek shade and have reduced appetite. Hypersensitivity to water has been noted, and convulsions may occur ... Additionally, phytoplasma diseases greatly reduced the essential oil yield of the plant. Although Hypericum perforatum is grown ...
Extracts of Helichrysum stoechas have been used in traditional medicine to treat colds, as a nerve tonic, to reduce ... The predominant active constituents are nerol acetate, curcumin, pinene, limonene, kaempherol, quercetin, luteolin, linalool, ...
Yu, M. C.; Chen, J. H.; Lai, C. Y.; Han, C. Y.; Ko, W. C. (2009). "Luteolin, a non-selective competitive inhibitor of ... Block F, Schmidt W, Nolden-Koch M, Schwarz M (2001). "Rolipram reduces excitotoxic neuronal damage". NeuroReport. 12 (7): 1507- ... Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Mesembrenone, an alkaloid from the herb ...
... glucoside Luteolin-7-glucoside Isorhamnetin 3-glucoside Luteolin-7-diglucoside Quercetin-7-glucoside Quercetin Luteolin Rutin ... In efforts to reduce inflammation and occasional constipation, dandelion root is often consumed. Dandelion root also has ... A 2016 study result's suggests that colon cancer cell's metabolic activity can be reduced with doses of dandelion root extract ...
Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Drotaverine, used to alleviate renal colic ... and reduce inflammation and innate immunity and nonselective adenosine receptor antagonists But different analogues show ... Yu MC, Chen JH, Lai CY, Han CY, Ko WC (2009). "Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, ...
Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 - PNAS ... Intestinal absorption of luteolin and luteolin 7-O-[beta]-glucoside in rats and humans". FEBS Letters, 438 (3), 220-224 (1998 ... Luteolin-7-glucoside (Cynaroside) and Luteolin-7-diglucoside found in dandelion coffee ... Luteolin-7-rutinoside (Veronicastroside). Šalutiniai efektai[redaguoti , redaguoti vikitekstą]. Luteolinas yra PDE4 ...
... luteolin, 'Unknown Flavonoid 3', and cyanidin. Chromatographic patterns of the N. × sarawakiensis samples studied showed ... and their wings are either greatly reduced or absent altogether. Two natural hybrids involving N. muluensis have been recorded ...
Yarrow can be used for dying wool as it contains apigenin and luteolin. Depending on the mordant the color may be green to ... The Cherokee drink a tea of common yarrow to reduce fever and aid in restful sleep. The occidentalis variety is used ... Shutler D, Campbell AA (2007). "Experimental addition of greenery reduces flea loads in nests of a non-greenery using species, ...
A specimen of N. × alisaputrana grown from tissue culture (in vitro) was also tested.[citation needed] Luteolin, cyanidin and ' ... Nepenthes burbidgeae could be grown in lower light conditions, but such plants exhibited etiolated growth and reduced ...
Flavones: Apigenin Luteolin Tangeritin Flavonols: Isorhamnetin Kaempferol Myricetin - walnuts are a rich source ... Another mechanism may be the increase in activities of paraoxonases by dietary antioxidants which can reduce oxidative stress. ...
A pair of fringed wings runs down the front of lower pitchers, while in upper pitchers these are often reduced to ribs. The ... luteolin, 'Unknown Flavonoid 3', and cyanidin. Chromatographic patterns of the N. × sarawakiensis samples studied showed ... and their wings are either greatly reduced or absent altogether. Nepenthes tentaculata is also similar to N. murudensis, which ...
Its existence in a field significantly reduces crop yield, both because it is a tough competitor for ground resources, and ... luteolin, quercetin, patchoulenone, isopatchoulenone, sugeonyl acetate, cellulose triacetate and sugebiol. A sesquiterpene, ...
CNN Philippines Staff (29 August 2020). "Lagundi trial gets green light, virgin coconut oil seen to reduce risk of coronavirus ... luteolin, p-hydroxybenzoic acid and D-fructose.[citation needed] The main constituents of the oil are sabinene, linalool, ...
Thus, this reaction yields a less oxidized (more reduced) form of the iron cation: Fe2+ and a less reduced (more oxidized) form ... Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as ... Myricetin reduces the risk of skin tumorigenicity that is caused by polycyclic aromatic hydrocarbons like benzo(a)pyrene, a ... Antioxidants, including flavonoids such as myricetin, are often touted to reduce the risk of atherosclerosis, the hardening of ...
αr35 is a family of bacterial small non-coding RNAs with representatives in a reduced group of α-proteobacteria from the order ... in S. meliloti 1021 under different biological conditions; i.e. bacterial growth in TY, minimal medium (MM) and luteolin-MM ... Supplementation of MM with luteolin, the plant flavone that specifically induces transcription of the S. meliloti nodulation ...
More recent work has reduced these to 4, which are commonly accepted today (in order from most basally to most recently ... luteolin, n-orientin, passiflorine (named after the genus), quercetin, rutin, saponarin, shaftoside, vicenin and vitexin. ...
Block F, Schmidt W, Nolden-Koch M, Schwarz M. (2001). "Rolipram reduces excitotoxic neuronal damage". Neuroreport 12 (7): 1507- ... Luteolin • Mesembrin • Piklamilast • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976 ...
Reduced NMDA receptor function has been linked to reduced social interactions, locomotor hyperactivity, self-injury, pre- ... Key aspects of neuropsychiatric disorders improved by luteolin". Frontiers in Neuroscience. 9: 225. doi:10.3389/fnins. ... The review found that CBT was moderately to highly effective at reducing anxiety in school children with autism spectrum ... Brain fog is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as ...
Qiusheng Z, Yuntao Z, Rongliang Z, Dean G, Changling L (July 2005). "Effects of verbascoside and luteolin on oxidative damage ... Addition of an acetyl group, which carries a negative charge, effectively removes the positive charge and hence, reduces the ... HDAC inhibitor trichostatin A was reported to reduce stress induced cardiomyocyte autophagy. Studies on p300 and CREB-binding ... reduced the interaction between DNA and histones. Histone modification is now considered a major regulatory mechanism that is ...
It has been shown to reduce oxidative damage to DNA in vitro and in animal studies. Cytotoxicity has been induced reportedly by ... Gutiérrez-Venegas, Gloria; Kawasaki-Cárdenas, Perla; Rita Arroyo-Cruz, Santa; Maldonado-Frías, Silvia (2006-07-10). "Luteolin ... Naringenin has been demonstrated to improve memory and reduce amyloid and tau proteins in a study using a mouse model of ... Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. ...
A high fat meal does reduce the Cmax slightly, but it is insignificant. In fact, food doesn't alter dapoxetine pharmacokinetics ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido ...
The alkene's double bond is typically reduced using hydrogen and a transition metal catalyst like Ni or Pt, while the nitro ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... Naloxone also reduced drinking. It was proposed that naloxone induced a state of frustrative nonreward. It was suggested that ... C double bond and the nitro-group in the resulting norcamphene derivative are then reduced to give the saturated norcamphane ...
It also reduces glutamate signaling via modulating sodium and calcium channels.[25][4] ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... "Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects" ...
This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... Preclinical studies have shown that benzodiazepines can be effective in reducing the effect of strokes for up to three days ... The positive side effects were anticonvulsant properties that reduced seizure number and intensity.[1] ... and reduced metabolites such as the tetrahydro derivative of progesterone 3α-hydroxy-5α-pregnane-20-one (3α,5α-THPROG). After ...
Bioavailability is reduced by presence of food in stomach. It is partly metabolised and partly excreted unchanged in urine.[29] ... The short half-life necessitates two or three times per day dosing, which may reduce patient compliance. ...
N-methylation of milnacipran in substituent group R4 and R5 reduces the norepinephrine and serotonin activity.[31] Researches ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... This property of SNRIs might be used to reduce doses of other pain relieving medication and lower the frequency of safety, ... Formation of norepinephrine is reduced by autoreceptors through the rate-limiting enzyme tyrosine hydroxylase, an effect ...
A single dose of ivermectin reduces microfilaridermia by 98-99% after 1-2 months.[14] Ivermectin does not kill adult worms. A ... In a clinical study, ivermectin reduced lesions by 83% over 4 months, as compared to 74% under a metronidazole standard therapy ... Field studies have demonstrated the dung of animals treated with ivermectin supports a significantly reduced diversity of ... of treating/preventing nematode infestation is effective for eliminating malaria-bearing mosquitos and thereby reducing ...
Inhibiting ethylene synthesis is less effective for reducing post-harvest losses since ethylene from other sources can still ...
... it gained FDA approval in the US for reducing COPD exacerbations.[10] ...
... medicine reduces seizure recurrence and improves remission) when compared to phenytoin and valproate the choice of medications ... decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are ... 01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions". Epilepsia. 55 (4): 496-506. doi: ... Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, ...
... reduces) the pro-inflammatory properties of the thromboxane TXA2. PGE1 has a role in regulation of immune system function and ... has been shown to reduce the symptoms of atopic dermatitis in a double-blind, placebo-controlled clinical trial.[12] ...
Modern anesthetic agents reduce these side effects.[14] Prior to 2005 it was on the World Health Organization's List of ... which reduces the formation of peroxides. Storage over sodium hydroxide precipitates the intermediate ether hydroperoxides. ...
... and reduces inflammation and innate immunity.[12] ... Luteolin. *Pentoxifylline. *Propentofylline. *Theobromine. * ...
This article is about the 3α,5β-reduced metabolite of progesterone. For other pregnanolone isomers of progesterone, see ...
... and dis-coordination induced by the drug greatly reduced soldiers' usefulness in the field. Amobarbital was once manufactured ...
Caution should be exercised by motor vehicle drivers.[5] In 2013 the FDA recommended the dose for women be reduced and that ...
It is the derivative of testosterone in which the double bond between the C4 and C5 positions has been reduced or hydrogenated. ... as it is already 5α-reduced), and for this reason, is not potentiated in so-called "androgenic" tissues like the skin, hair ...
Nitrosyl chloride followed by base leads to the oxime 8 which can be reduced to "pinylamine" 9. Both 8 and 9 are stable ... α-Pinene in particular is thought to reduce the memory deficits commonly reported as a side-effect of THC consumption. It ...
... in vitro can restore the reduced HDAC (histone deacetylase) activity that is induced by oxidative stress (i.e., in ...
... and the blocking of this influx therefore reduces the ability of the muscle to contract.[10] In this way, glaucine can prevent ...
Luteolin, Apigenin, Tangeritin Flavonol. or. 3-hydroxyflavone 3-hydroxy-2-phenylchromen-4-one ✓ ✗ Quercetin, Kaempferol, ... Dietary flavonoid intake is associated with reduced gastric carcinoma risk in women,[42] and reduced aerodigestive tract cancer ... "Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure". Biotechnol. ...
Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in ...
In contrast to the sexual diploids, the pairing of chromosomes at metaphase I in triploid apomicts is strongly reduced. However ... Dandelion contains flavonoids including luteolin, apigenin, isoquercitrin (a quercetin-like compound), caffeic acid, and ...
Finally, BLT2 receptor expression was significantly reduced in allergy-regulating CD4+ T cells from patients with asthma ... inhibits TXA2-mediated platelet activation responses while 12-oxo-HT blocks TXA2 receptor binding to reduce not only TXA2- ...
These variants are associated with reduced levels of ALOX5 as well as reduced production of LTC4 in their eosinophils.[53] ... Studies in this model suggest that Alox5, acting through one or more of its metabolites, reduces growth and progression of the ... Ubiquitous cellular glutathione peroxidases (GPXs) reduce 5-HpETE to 5-hydroxyeicosatetraenoic acid (5-HETE); 5-HETE may be ... The 5S-HpETE intermediate may then be released by the enzyme and rapidly reduced by cellular glutathione peroxidases to its ...
"Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test". Pain. 138 (2): 402-409. doi:10.1016/j ...
... decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are ... 01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions". Epilepsia. 55 (4): 496-506. doi: ... Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, ...
... , marketed as Penthrox among others, is an inhaled medication primarily used to reduce pain following trauma.[2][ ...
Catalytic hydrogenation over Raney nickel to reduce nitro group, followed by reduction with sodium borohydride provides the ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
In the U.K., a generic version of tadalafil became available in November 2017, reducing its price per pill, and will be ... The presence of other drugs which induce this system can shorten tadalafil half-life and reduce serum levels, and hence ...
Luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in ... Luteolin consumption reduced LPS-induced IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the induction of ... Whereas luteolin had no effect on the LPS-induced increase in NF-kappaB DNA binding activity, it markedly reduced AP-1 ... Luteolin, a flavonoid found in high concentrations in celery and green pepper, has been shown to reduce production of ...
Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages. ... Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages ... Lopez-Lazaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 9:31-59 CrossRef ... Liu JF, Ma Y, Wang Y, Du ZY, Shen JK, Peng HL (2011) Reduction of lipid accumulation in HepG2 cells by luteolin is associated ...
... By Ralph Turchiano on September 10, 2012. • ( 3 ) ... 3 thoughts on "Plant flavonoid found to reduce inflammatory response in the brain: luteolin" * ADHD insights: Inflammation and ... Home › Disease and Conditions › Plant flavonoid found to reduce inflammatory response in the brain: luteolin ... The purpose of the study was to determine if luteolin could also reduce inflammation in the brain, said animal sciences ...
Luteolin was shown to trigger apoptosis (programmed cell death) by arresting the normal cell cycle that typically results in ... The study leader, Professor Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF- ... Researchers from Korea found that in a controlled setting, application of the flavonoid luteolin to colon cancer cells blocked ... luteolin is able to inhibit the activity of cell signaling pathways (known as IGF and PI3K) important for the growth of colon ...
Kim, H. J., Woo, J. H., Nam, Y. R., Seo, Y., Namkung, W., Nam, J. H., & Kim, W. K. (2020). Luteolin reduces fluid ... Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells. In: Korean ... Kim, HJ, Woo, JH, Nam, YR, Seo, Y, Namkung, W, Nam, JH & Kim, WK 2020, Luteolin reduces fluid hypersecretion by inhibiting ... Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells. Korean ...
... mitochondrial membrane potential was reduced by luteolin as seen on fluorescence microscopy. Luteolin downregulated the ... Similarly, luteolin significantly reduced the expression of proliferating cell nuclear antigen (PCNA) as well as increased the ... Luteolin exhibited antiproliferative activity against LLC cells with IC50 of 12 microM. Luteolin effectively increased Annexin- ... In addition, luteolin significantly inhibited the growth of LLC cells implanted on the flank of mice to 40% and 60% of ...
Both orientin and luteolin reduced oxidative products and increased antioxidative enzyme activities. Moreover, orientin and ... Even with highest concentration of either orientin or luteolin, they could not reduce ROS and MDA content to normal erythrocyte ... Effects of Orientin and Luteolin on Hemolysis of Erythrocytes. The effects of orientin and luteolin on hemolysis rate of ... From oxidative stress hypothesis, any chemicals that can reduce oxidative stress would have ability to reduce erythrocyte ...
... luteolin-5-methyl ether; 13: cinnamyliden acetic acid; 14: pinobanksin derivative; 15: isorhamnetin; 16: pinocembrin; 17: ... Finally, the resulting material was dissolved in a reduced volume of 80% ethanol (v/v) in order to obtain an EEP in which the ... Then, the fetal bovine serum content on culture media was reduced to 1% and the cells were stimulated with LPS 100 ng/mL (Sigma ... C. L. Herrera, O. Fritz, G. Montenegro, M. Alvear, M. del Sol, and L. A. Salazar, "El Propóleos Reduce la Esteatosis Hepática ...
Luteolin reduces IFN-γ. Quercetin inhibits IFN-γ. [Leyva-López et al. 2016] The effect of luteolin was previously confirmed by ... 2016 review how the flavenoids apigenin, fisetin, luteolin, and quercetin all inhibit or reduce IL-1β. Also, apigenin, fisetin ... They may be useful during a cytokine storm condition, since they reduce TLR9 triggered cytokines, reduce TNF-α & IL-6 and work ... Zinc can reduce the time a person is sick by 33% in the general case (Hemilä 2017). Zinc is very useful in regulating immune ...
Reduces CDK2 and CDK4 and consequently attenuates cyclin E and D1 and strength of p21 expression; reduces expression of COX-2 ... Luteolin. Luteolin is mainly found in vegetables rather than fruits [73], including celery, carrots, parsley, and mint. The ... Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon ... reducing the expression of cyclin A, D, and E; reducing the effect of CDK2 and CDK4; and stimulating the activity of p21, p27, ...
Anti-bacterial Peanut Shell Extract Luteolin 98%,Luteolin,Peanut Shelll Extract Powder,Luteolin Powder from Other Extracts ... Anti-bacterial Peanut Shell Extract Luteolin 98% , Find Complete Details about Anti-tumor& ... 3.Luteolin has the function of relaxating and protecting vascular.. 4.Luteolin can reduce the level of hepatic fibrosis and ... Application of Luteolin Powder:. 1.Luteolin applied in food field, Luteolin is often used as food additives.. 2.Luteolin ...
Again, a study has shown that increasing your intake of luteolin can reduce brain inflammation. As a result, its easier to ... WebMD: Eat Smart for a Healthier Brain) Avocados can also reduce risk of hypertension, one of the health factors that is known ... Huffington Post: Can Celery Keep Your Brain in Shape?) Its important to note that reducing inflammation is one of the best ... Celery has much more to offer than a satisfying crunch; its also packed full of the flavonoid luteolin. Flavonoids help cells ...
Luteolin, a lemon blam flavonoid, may contribute to reducing anxiety through modulating motor movements and locomotion. Feb 01 ... Valerian and lemon balm may assist in reducing symptoms of sleep disorder during the menopause.Oct 31, 2013. ... Lemon balm extract considerably reduced hyperglycemia and insulin resistance, plasma triacylglycerol, nonesterified fatty acids ...
Luteolin reduces IL-6 production in some neurons. Jones SA, Scheller J, Rose-John S (2011). "Therapeutic strategies for the ... Jang S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and ...
These include quercetin, curcumin, resveratrol, luteolin, lycopene, and silymarin. All of the above supplements reduce ...
When co-incubated with luteolin, LPS-activated microglia showed strongly reduced NO secretion and significantly decreased ... Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. ... Luteolin treatment had a major effect on microglial morphology leading to ramification of formerly amoeboid cells associated ... Luteolin dose-dependently suppressed pro-inflammatory marker expression in LPS-activated microglia and triggered global changes ...
The results showed that luteolin and phospholipid in the complex were joined by non-covalent-bonds and did not form a new ... A luteolin and phospholipid complex was prepared to improve the lipophilic properties of luteolin. The physicochemical ... Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1.. *Saebyeol Jang, Keith ... Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans.. *Kayoko Shimoi, Hiromasa Okada, +6 ...
Scientists call these two compounds apigenin and luteolin.. Research shows that apigenin and luteolin reduce inflammation and ... Celery contains luteolin, which may help reduce inflammation for people with allergic asthma.. ... Results showed that giving the mice luteolin 30 minutes before exposing them to an allergen significantly reduced the levels of ... A 2017 study investigated whether luteolin could reduce inflammation and lower allergic responses in mice with these conditions ...
Luteolin Reduces Alzheimers Disease Pathologies Induced by Traumatic Brain Injury. Previous Article in Special Issue. ... After 4 days exposure to paraoxon, only concentrations higher than 200 μM reduced cell viability (p , 0.05) (Figure 1), while ... Previous studies with mipafox have reported that different NTE inhibiting neuropathic OPs caused reduced neurites length in the ... 5 μM of mipafox was able to reduce NTE enzymatic activity. No modifications were observed in mRNA levels, indicating that NTE ...
... , Wei Wang, Fu- ... Luteolin reduces tumour volume mice. We also checked the effect of luteolin in mice (in-vivo) and we have observed that ... Luteolin preparation. Luteolin was purchased from Sigma Aldrich (USA). One microgram Luteolin was dissolved in 100 μl of DMSO ... We measured the tumour volume and found that it was reduced almost 95% by volume when treated with luteolin as shown in Figure ...
7B, b and c). The combination of luteolin and rapamycin further reduced HER2 staining when compared with using luteolin alone ( ... The second to fifth groups were given i.p. with luteolin (5 mg/kg), luteolin (50 mg/kg), rapamycin (1 mg/kg), and luteolin (5 ... were also reduced by luteolin (Fig. 4; Supplementary S5).3 Furthermore, our unpublished data indicated that luteolin was also ... 7B, f), p21 was induced by low doses of luteolin (Fig. 7B, g) and inhibited by high doses of luteolin (Fig. 7B, h). As with the ...
Luteolin: also fights inflammation and may help protect against inflammatory brain conditions like Alzheimers. Found in celery ... Quercetin: fights inflammation and may help reduce allergies. Found in apples, onions, teas and red wines. ... Catechins: may help reduce risk of heart disease, cancer, and Alzheimers disease. Found in tea. ...
In parallel with these changes, the AUC0-7h of digoxin was also reduced. Hence, uptake of a reduced P-gp substrate (for example ... Moreover, the literature study reveals no description of luteolin transporters, although the metabolism of luteolin widely ... Apple juice greatly reduces systemic exposure to atenolol. Br. J. Clin. Pharmacol. 2013, 75, 172-179. [Google Scholar] [ ... Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clin. Pharmacol. Ther. 2014, 95, 432- ...
Apigenin and luteolin prevented MMP1-induced FAK activation, but not constitutive FAK phosphorylation. Luteolin, unlike ... Apigenin and luteolin were tested in a three-dimensional (3-D) assay consisting of MDA-MB231 breast cancer spheroids and ... Apigenin and luteolin were tested in a three-dimensional (3-D) assay consisting of MDA-MB231 breast cancer spheroids and ... Hence, we studied two flavonoids, apigenin and luteolin exhibiting strong bio-activity in various test systems in cancer ...
Outrageous cost and reduced number of new drug approvals are serious challenges to the new drug discovery. The major task in ... Luteolin obstructs epithelial mesenchymal transition. Flavanones, isoflavones and lignans prevent binding of the estrogen to ... Rosmarinic acid reduces COX-2 activity and Erk phosphorylation in colon cancer cells (Hossan et al., 2014). In breast cancer ... Kuo, M. C., Chang, S. J., and Hsieh, M. C. (2015). Colchicine significantly reduces incident cancer in Gout male patients. ...
LUT pretreatment reduced miR-208b-3p expression in myocardial tissue, as compared to the I/R group. And LUT decreased miR-208b- ... Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects ... Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p.. [Chen Bian, ...
Luteolin: How To Reduce Breast Cancer Risk. More than 100 women die of breast cancer in the U.S. every day. Its the second ... Since mid-July they have been reducing their numbers and sealing up the hives withpropolis. Dark brown, sticky when fresh, ...
Luteolin: How To Reduce Breast Cancer Risk. More than 100 women die of breast cancer in the U.S. every day. Its the second ... Medical News Today: Breast cancer treatment: Can Brussels sprouts, soy reduce side effects?. Researchers have found that soy ... Brussels sprouts found to reduce your risk of cancer. (Natural News) If you have been eating kale for its health benefits, you ... Symptoms can be reduced by eating lots of plant foods, especially those rich in phytoestrogens, which help to rebalance your ...
Palmitoylethanolamide and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based ... Palmitoylethanolamide reduces the degree of ocular inflammation in a rat model of endotoxin-induced uveitis.Aug 14, 2015. ... Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016. ... Palmitoylethanolamide and luteolin may be beneficial in demyelinating disorders such as multiple sclerosis.Aug 17, 2017. ...
Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ... Luteolin is a bioactive flavonoid, isolated and characterized from the leaves of Vitex negundo. Lenses were extracted from ... Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo.. Rooban BN1, ... The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. In the ...
  • The current study investigated the effects of two plant-derived flavonoids, orientin and luteolin, on erythrocytes and their possible mechanisms. (hindawi.com)
  • Flavonoids help cells fight off the aging process, and they also reduce inflammation in the body. (lifehack.org)
  • Luteolin shown in Figure 1 is one of the important dietary flavonoids which are commonly present in various fruits and vegetables. (alliedacademies.org)
  • Hence, we studied two flavonoids, apigenin and luteolin exhibiting strong bio-activity in various test systems in cancer research and are readily available on the market. (frontiersin.org)
  • Luteolin is one of the few flavonoids that is not readily absorbed by the body. (naturalpedia.com)
  • Quercetin, luteolin and epigallocatechin gallate (EGCG) are flavonoids with beneficial effects on cardiovascular functions, and we wondered whether these flavonoids protect endothelial functions against ER stress-associated impairments. (nih.gov)
  • One thing they discovered is that the flavonoids apigenin and luteolin have the ability to inhibit an enzyme that is critical in pancreatic cancer . (emaxhealth.com)
  • However, eating lots of vegetables and fruits throughout a lifetime will expose you to flavonoids, "which would certainly help to reduce the risk of cancer," explained de Mejia. (emaxhealth.com)
  • Johnson JL, Gonzalez de Mejia E. Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cell, in vitro. (emaxhealth.com)
  • Scientists also discovered sage contains other health-promoting compounds - volatile oils, flavonoids (apigenin, diosmetin and luteolin), tannins and phenolic acids. (melissas.com)
  • Flavonoids possess antioxidant and anti-inflammatory properties and can reduce the expression of key inflammatory molecules. (koreamed.org)
  • 2. Of the flavonoids examined, luteolin (Lu) and quercetin (Qu) were the two most potent agents, and significantly inhibited A431 cell proliferation with IC50 values of 19 and 21 micronM, respectively. (nih.gov)
  • According to the researchers, these benefits could be due to the presence of flavonoids , including luteolin, apigenin, quercetin, and proanthocyanidins, which contain many polyphenolic compounds. (naturalnews.com)
  • Previously, we described the flavone luteolin and especially the flavonol quercetin as being potent antioxidants that inhibit myelin phagocytosis by macrophages ( 7 ). (rupress.org)
  • 2015;2015:474032 - 'Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). (qualitycounts.com)
  • Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1β expression. (nih.gov)
  • PA stimulation induced inflammation accompanied by the loss of NO production in endothelial cells, but these alterations were reversed by treatment with quercetin, luteolin and EGCG. (nih.gov)
  • In conclusion, quercetin, luteolin and EGCG inhibited ER stress-associated TXNIP and NLRP3 inflammasome activation, and thereby protected endothelial cells from inflammatory and apoptotic damage. (nih.gov)
  • Celery's narrow green stalks are great sources of phytonutrients such as phenolic acids, luteolin, and quercetin. (jonbarron.org)
  • 5. The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase. (nih.gov)
  • The researchers first studied the effect of luteolin on microglia. (clinicalnews.org)
  • In nude mice with xenografted SKOV3.ip1-induced tumors, luteolin significantly inhibited HER2 expression and tumor growth in a dose-dependent manner, and rapamycin further enhanced the effect of luteolin with a concomitant p21 inhibition. (aacrjournals.org)
  • These finding demonstrated the anticataractogenic effect of luteolin by virtue of its antioxidant property, which has been reported in this paper for the first time. (nih.gov)
  • This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization. (arvojournals.org)
  • The effect of luteolin on tertiary-butylhydroperoxide (t-BH)-induced ROS production was measured with 2′7′-dichlorofluorescein diacetate. (arvojournals.org)
  • The effect of luteolin on t-BH-induced and hypoxia-induced VEGF transcription and expression were evaluated by RT-PCR and Western blot, respectively. (arvojournals.org)
  • Taken together, these results suggest that luteolin exerts antitumor activity by caspase activation and ERK/Akt inhibition. (nih.gov)
  • Furthermore, studies on animals suggest that luteolin could enhance the potency of chemotherapy drugs that act on cancer cells while reducing the toxic effects of these drugs on the body. (medicalnewstoday.com)
  • although this does not in any way suggest that luteolin does not offer any health benefits. (naturalpedia.com)
  • Our results suggest that luteolin could be a potent anti-angiogenic agent for retinal neovascularization, which is related to anti-oxidative activity to block ROS production and to subsequently suppress VEGF expression and the pro-angiogenic effect of VEGF. (arvojournals.org)
  • Scientists call these two compounds apigenin and luteolin . (medicalnewstoday.com)
  • Research shows that apigenin and luteolin reduce inflammation and may help treat a range of inflammatory diseases. (medicalnewstoday.com)
  • Apigenin and luteolin were tested in a three-dimensional (3-D) assay consisting of MDA-MB231 breast cancer spheroids and immortalized lymph endothelial cell (LEC) monolayers. (frontiersin.org)
  • Apigenin and luteolin prevented MMP1-induced FAK activation, but not constitutive FAK phosphorylation. (frontiersin.org)
  • Two in particular, apigenin and luteolin, have been shown in several investigations to provide some protection from one of the most-deadly forms of this disease, pancreatic cancer. (jonbarron.org)
  • Luteolin, a flavonoid found in high concentrations in celery and green pepper, has been shown to reduce production of proinflammatory mediators in LPS-stimulated macrophages, fibroblasts, and intestinal epithelial cells. (greenmedinfo.com)
  • As further studies are planned to better understand the impact of luteolin on colon cancer progression, most adults will want to ensure a regular intake by consuming plenty of vegetables including celery hearts, hot peppers, parsley or spinach or supplement with a full-spectrum multi-vitamin containing the flavonoid. (blogspot.com)
  • Another nice perk of adding celery to your diet is that there is some evidence that luteolin can help combat neurological diseases. (lifehack.org)
  • If you're not a fan of celery, you can get the same luteolin benefits by eating carrots instead. (lifehack.org)
  • Luteolin is the pigment that gives foods such as celery and parsley their lovely, green color. (naturalpedia.com)
  • Eating about two sticks of celery per day can help reduce the amount of bad cholesterol in your body. (davidwolfe.com)
  • One glass of celery juice per day helps reduce the swelling and pain associated with these conditions. (davidwolfe.com)
  • Luteolin is a common type of natural flavonoid that is abundant in the leaves of celery, green pepper and dandelion. (alliedacademies.org)
  • Luteolin is found in bell peppers, celery, rosemary and thyme. (eatingwell.com)
  • Lowers Cholesterol - Laboratory studies also indicate that butyl phthalide, a chemical in celery, may help reduce LDL (bad) cholesterol. (naturalnews.com)
  • According to researchers at the University of Chicago, celery reduces cholesterol levels by as much as 7 points with as little as 2 stalks a day. (naturalnews.com)
  • Luteolin is found in carrots, rosemary, celery and other foods. (lifeextension.com)
  • Celery also contains luteolin, a seldom-mentioned but potent antioxidant. (saveourbones.com)
  • And celery was shown in a 2010 study at King Saud University in Riyadh, Saudi Arabia to benefit the lining of the stomach and reduce the occurrence of stomach ulcers. (jonbarron.org)
  • Olive oil, peppers and celery are also high in luteolin. (cakehealth.com)
  • Luteolin is a flavonoid that exists in a glycosylated form in celery and green pepper. (koreamed.org)
  • Celery can help reduce blood pressure and inflammation. (alignlife.com)
  • Other active compounds in celery include coumarins which have been shown to protect against cancer, and the bioflavonoid known as luteolin. (alignlife.com)
  • It contains luteolin , a phytochemical that has many health benefits. (davidwolfe.com)
  • Parsley contains luteolin and vitamin C that is an effective anti-inflammatory agent of the body. (hubpages.com)
  • Luteolin was shown to trigger apoptosis (programmed cell death) by arresting the normal cell cycle that typically results in uncontrolled growth. (blogspot.com)
  • Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. (nih.gov)
  • Next we studied the underlying mechanism of luteolin action, and found its inducing apoptosis of HepG2 cell, apoptosis was monitored based on propidium iodide internalization assay using flow cytometer (FACS). (alliedacademies.org)
  • Altogether our result clearly showed the details mechanistic pathway by which luteolin is inducing apoptosis in HepG2. (alliedacademies.org)
  • Luteolin effectively inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. (aacrjournals.org)
  • To test this hypothesis, we showed that the combined use of luteolin and mTOR inhibitor rapamycin prevented low doses of luteolin from inducing p21 expression, and HER2-overexpressing cancer cells would be sensitized toward luteolin-induced apoptosis. (aacrjournals.org)
  • Luteolin and lapatinib synergistically induced the apoptosis of BT474 cells. (alliedacademies.org)
  • The present study demonstrates that synergistic use of luteolin with lapatinib inhibits the growth of breast cancer cells, possibly by inducing apoptosis via the deactivation of AKT and ERK signaling pathways. (alliedacademies.org)
  • Luteolin has been found to inhibit CRC cells proliferation, induce cells apoptosis and cell cycle perturbation ( 13 - 15 ). (spandidos-publications.com)
  • In prostate cancer cells, luteolin treatment inhibited prostate cancer cells proliferation and induced apoptosis through downregulation of miR-301 by triggering DEDD2 expression ( 25 ). (spandidos-publications.com)
  • Luteolin also inhibited the tumorigenesis and induced the apoptosis of non-small cell lung cancer cells by upregulation of miR-34a-5p by targeting MDM4 ( 26 ). (spandidos-publications.com)
  • Apoptotic assays revealed that the multi-heavy metal mixture induced HL7702 cell apoptosis in a dose-dependent manner, which was significantly inhibited by 20 µM luteolin. (spandidos-publications.com)
  • The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway. (spandidos-publications.com)
  • In conclusion, orientin and luteolin could protect human erythrocytes from oxidative damage by attenuating oxidative stress, protecting antioxidative enzyme activities, and preserving integrity of erythrocyte structure. (hindawi.com)
  • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. (greenmedinfo.com)
  • Consistent with this finding, luteolin did not inhibit LPS-induced degradation of IkappaB-alpha but inhibited JNK phosphorylation. (greenmedinfo.com)
  • Jang found that luteolin inhibited JNK phosphorylation in microglial cell culture. (clinicalnews.org)
  • Combination of lapatinib and luteolin reduced the phosphorylation level of AKT and ERK1/2 in BT474 cells. (alliedacademies.org)
  • Product Name: peanut shell extract luteolin 98% Latin Name: Arachis hypogaea L. (trader-china.com)
  • We have also measured how different concentrations of luteolin effects on cell proliferation of HepG2 over 48 h of window. (alliedacademies.org)
  • The cells were incubated with different concentrations of luteolin and/or lapatinib. (alliedacademies.org)
  • Carrots have high levels of a compound called luteolin , which could reduce age-related memory deficits and inflammation in the brain, according to a study published in 2010 in the journal Nutrition. (cakehealth.com)
  • A plant compound called luteolin, largely found in carrots, reduces the inflammation of brain cells that causes aging of the brain. (ayurvediccure.com)
  • Luteolin is one of a number of natural plant-derived compounds that are known to exhibit powerful anti-inflammatory, antioxidant and anti-cancer properties. (blogspot.com)
  • Physicochemical properties and antioxidant activities of luteolin-phospholipid complex. (semanticscholar.org)
  • The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. (nih.gov)
  • Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ROS generation and lipid peroxidation in the lens. (nih.gov)
  • Astaxanthin (from Regenurex) is a powerful antioxidant and helps reduce inflammation, so natural healing can occur. (life-enthusiast.com)
  • Vitamin C is the chief water-soluble antioxidant of the body, which helps reduce the risks of various conditions, such as atherosclerosis, colon cancer, diabetes, and asthma. (hubpages.com)
  • Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion ( Taraxacum officinale ) flower extract were studied for antioxidant activity in different in vitro model systems. (springer.com)
  • The study, published today in Cancer Prevention Research, a journal of the American Association for Cancer Research, involved the use of microscopic amounts of the naturally occurring antioxidant, luteolin, that were encapsulated in a water-soluble polymer. (redorbit.com)
  • The treated group also exhibited an increase in antioxidant enzymes while liver enzymes, such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, and lipid peroxidation were reduced. (naturalnews.com)
  • Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics. (semanticscholar.org)
  • This implicates that the pro-intravasative contribution of FAK and of Ca 2+ release in LECs was independent of each other and explains the better anti-intravasative effects of luteolin in vitro . (frontiersin.org)
  • Free radical mediated oxidative stress plays a crucial role in the pathogenesis of cataract and the present study was to determine the efficacy of luteolin in preventing selenite induced oxidative stress and cataractogenesis in vitro. (nih.gov)
  • It was demonstrated that luteolin had no effects on CRC cells proliferation while inhibited cells migration and invasion both in vitro and in vivo. (spandidos-publications.com)
  • There is a wealth of evidence that prove the efficacy of luteolin in cancer growth interference . (naturalpedia.com)
  • In the present study, we examined the underlying molecular mechanism of luteolin and its effect on in vivo tumor growth of Lewis lung carcinoma (LLC) cells. (nih.gov)
  • The promising anticancer potential of luteolin can be effectively utilized in future for anticancer drug development. (alliedacademies.org)
  • Luteolin (luteolin) is a natural flavonoid found in many plants. (alibaba.com)
  • The result of a body of research published in the journal BMC Gastroenterology has found that consumption of the plant flavonoid, luteolin is able to inhibit the activity of cell signaling pathways (known as IGF and PI3K) important for the growth of colon cancer. (blogspot.com)
  • Liu et al also reported that luteolin was able to inhibit CRC cells epithelial to mesenchymal transition by suppressing CREB1 expression ( 16 ). (spandidos-publications.com)
  • By using a high concentration of luteolin in the blood, we were better able to inhibit the growth of cancer cells. (redorbit.com)
  • Similarly, luteolin significantly reduced the expression of proliferating cell nuclear antigen (PCNA) as well as increased the expression of terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) in tumor section of LLC-bearing mice as determined by immunohistochemistry. (nih.gov)
  • Results showed that giving the mice luteolin 30 minutes before exposing them to an allergen significantly reduced the levels of inflammation within their lungs and nasal passages. (medicalnewstoday.com)
  • Oral administration of luteolin also significantly reduced clinical symptoms. (rupress.org)
  • According to a presentation at FASEB in Boston, researchers led by Patrick Martin, PhD, associate professor of biology at North Carolina Agricultural and Technical State University (NCATSU) in Greensboro, showed that Rose Hip extract significantly reduced the growth and migration of cells from TNBC. (canceractive.com)
  • In addition, pretreatment with luteolin followed by gemcitabine significantly reduced expression of certain substances involved in the advancement of pancreatic cancer. (emaxhealth.com)
  • In a subsequent study of 75 otherwise healthy people with high cholesterol, artichoke leaf extract significantly reduced total cholesterol compared to placebo, but it did not affect LDL, HDL, or triglycerides levels. (westfloridahospital.com)
  • The ajwa date extract increased the anti-tumor cytokines and significantly reduced tumors in mice. (naturalnews.com)
  • One phenolic acid, rosmarinic acid, reduces inflammation by altering concentrations of inflammatory messaging molecules. (melissas.com)
  • Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. (semanticscholar.org)
  • The present study demonstrated that luteolin exerts anticancer effects against CRC cells by modulating PTN via miR‑384 expression suggested that PTN may serve as a promising candidate for therapeutic applications in CRC treatment. (spandidos-publications.com)
  • For example, luteolin inhibits the proliferation of lung adenocarcinoma A549 cells via PI3K-Akt-IkBα-Snail signaling pathway by down-regulating the expression of E-cadherin [ 13 ]. (alliedacademies.org)
  • Luteolin inhibits the proliferation of tumor cells and interferes with the ability of tumors to set up their own blood supplies. (alignlife.com)
  • First, resveratrol reduced NADPH oxidase-mediated generation of reactive oxygen species. (aspetjournals.org)
  • Therefore, eliminating excess free radicals could reduce membrane lipid peroxidation and protect erythrocytes from oxidative injury. (hindawi.com)
  • By reducing the damage caused by free radicals, as well as shielding different cells from outside damage, the compound ensures overall well-being. (naturalpedia.com)
  • Active H2 from QuintEssential reduces free radicals, supports your immune system, and boosts physical and mental energy. (life-enthusiast.com)
  • Parsley has been found to be rich in various antioxidants, such as luteolin, a flavonoid that eliminates free radicals in the body. (hubpages.com)
  • Catechins in green tea help scavenge the free radicals that are produced during detoxification and also reduces inflammation of the liver. (medindia.net)
  • The evidence suggested that free radicals generated in the vicinity of the endothelium reduced endothelial function, caused vasoconstriction and led to increases in blood pressure and an enhanced thrombotic tendency. (scirp.org)
  • Next we measured ROS generation ability and lipid peroxidation effect induced by luteolin and measured using TBARS assay. (alliedacademies.org)
  • The toxicity of luteolin was evaluated through modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in human retinal microvascular endothelial cells (HRMECs) as well as TUNEL staining in the retina of C57BL/6J mice. (arvojournals.org)
  • Anti-angiogenic activity of luteolin was evaluated by VEGF-induced migration and tube formation assay. (arvojournals.org)
  • An MTT assay demonstrated that 20 µM luteolin significantly alleviated the multi-heavy metal mixture-induced cell death and morphological changes. (spandidos-publications.com)
  • A JC-1 staining assay indicated that 20 µM luteolin inhibited the mitochondrial membrane potential-reducing effect of the multi-heavy metal mixture. (spandidos-publications.com)
  • To see if luteolin might have a similar effect in vivo, the researchers gave mice luteolin-laced drinking water for 21 days before injecting the mice with LPS. (clinicalnews.org)
  • When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working memory to what was seen in young cohorts," Dr Johnson stated. (lifeextension.com)
  • Because excessive production of proinflammatory cytokines by activated brain microglia can cause behavioral pathology and neurodegeneration, we sought to determine whether luteolin also regulates microglial cell production of a prototypic inflammatory cytokine, IL-6. (greenmedinfo.com)
  • Animal sciences professor Rodney Johnson, and graduate student Saebyeol Jang found that a plant flavonoid, luteolin, inhibited a key pathway in the inflammatory response of microglia. (clinicalnews.org)
  • Those cells that were also exposed to luteolin showed a significantly diminished inflammatory response. (clinicalnews.org)
  • Jang showed that luteolin was shutting down production of a key cytokine in the inflammatory pathway, interleukin-6 (IL-6). (clinicalnews.org)
  • 1.Luteolin has the function of anti-inflammatory, anti-microbial and anti-virus. (alibaba.com)
  • Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. (semanticscholar.org)
  • Luteolin has been reported to display a wide range of bioactive properties, such as anti-virus ( 1 , 2 ), hepatoprotective ( 3 ), anti-inflammatory ( 4 ) and anti-diabetic effects ( 5 ). (spandidos-publications.com)
  • Luteolin is a antiallergic, anticancer, anti-inflammatory plant flavonoid. (openwetware.org)
  • The neurons survived because the luteolin inhibited the production of neurotoxic inflammatory mediators. (lifeextension.com)
  • We believe dietary luteolin accesses the brain and inhibits or reduces activation of microglial cells and the inflammatory cytokines they produce. (lifeextension.com)
  • Luteolin is known for its anti-inflammatory and anti-cancer effects. (redorbit.com)
  • Luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia and may be useful for mitigating neuroinflammation. (greenmedinfo.com)
  • To determine how luteolin inhibited IL-6 production in microglia, EMSAs were performed to establish the effects of luteolin on LPS-induced binding of transcription factors to the NF-kappaB and activator protein-1 (AP-1) sites on the IL-6 promoter. (greenmedinfo.com)
  • Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. (greenmedinfo.com)
  • While pretreatment of neurons with luteolin showed no benefit, exposure of microglia to this compound prevented neuron death. (lifeextension.com)
  • Carrots contain luteolin, a flavonoid believed to reduce inflammation that can lead to cognitive decline. (eatingwell.com)
  • In this study, we showed that luteolin, a naturally occurring flavonoid, is a potent stimulator of HER2 degradation. (aacrjournals.org)
  • Luteolin has actually been found to be more potent than Vitamin C in reducing DNA oxidative damage. (saveourbones.com)
  • Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. (spandidos-publications.com)
  • Luteolin (3,4,5,7-tetrahydroxyflavone) is a natural flavonoid abundant in various fruits and vegetables. (spandidos-publications.com)
  • Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). (springermedizin.de)
  • Our results suggest that nanoparticle delivery of naturally occurring dietary agents like luteolin has many advantages," says senior study author Dong Moon Shin, MD, professor of hematology and medical oncology at Emory University School of Medicine and associate director of academic development at Winship Cancer Institute. (redorbit.com)
  • In children with autism, improvement may be seen with a luteolin-containing dietary formulation. (alignlife.com)
  • Luteolin has inhibitory effects on several types of malignant tumors. (alliedacademies.org)
  • The inhibitory effects were further attributed to the suppression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression, and not reduced enzymatic activity. (springer.com)
  • In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy metals (including zinc, manganese, lead, copper, cadmium, mercury, chromium and nickel) were investigated in HL7702 hepatocyte cells. (spandidos-publications.com)
  • Researchers from Korea found that in a controlled setting, application of the flavonoid luteolin to colon cancer cells blocked the secretion of IGF-II within a time period of two hours. (blogspot.com)
  • Researchers at Tufts University Report Blueberries May Reduce Memory Loss ) was found to improve short-term memory and reverse motor function deficits. (lifehack.org)
  • In a new study published in the journal Springer Plus , University of Missouri researchers found that luteolin can decrease breast cancer risk in women taking hormone replacement therapy. (doctorshealthpress.com)
  • In the lab, luteolin was administered to human breast cancer cells and researchers used luteolin to observe the stem cell-like characteristics in the cancer cells. (doctorshealthpress.com)
  • Researchers found that luteolin also reduced stem cell-like characteristics and blood vessel formation when tested in mice with breast cancer. (doctorshealthpress.com)
  • The Greeks and Romans used it as a preservative for meats, and sage's ability to reduce spoilage via numerous terpene antioxidants is now being confirmed by researchers. (melissas.com)
  • Furthermore, mitochondrial membrane potential was reduced by luteolin as seen on fluorescence microscopy. (nih.gov)
  • Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2-overexpressing cancer cells. (aacrjournals.org)
  • The present study is to investigate the synergistic effect of lapatinib and luteolin in the inhibition of the growth and proliferation of breast cancer cells, as well as the underlying mechanisms. (alliedacademies.org)
  • miR‑384 inhibition and PTN overexpression partially reversed the inhibition of HT‑29 cells migration and invasion induced by luteolin. (spandidos-publications.com)
  • One of the questions we were interested in is whether something like luteolin, or other bioactive food components, can be used to mitigate age-associated inflammation and therefore improve cognitive function and avoid some of the cognitive deficits that occur in aging," Johnson said. (clinicalnews.org)
  • The findings indicate a possible role for luteolin or other bioactive compounds in treating neuroinflammation, Johnson said. (clinicalnews.org)
  • Luteolin is a bioactive flavonoid, isolated and characterized from the leaves of Vitex negundo. (nih.gov)
  • In previous studies Dr. Beatrice Bachmeier demonstrated that curcumin significantly reduces the incidence of metastases to the lungs in breast cancer patients. (canceractive.com)
  • Mice studies have shown that luteolin was particularly efficient in reducing tumor growth in ovarian cancer cells. (naturalpedia.com)
  • DHT also reduced the generation of proinflammatory cytokines majorly in tumor necrosis factor (TNF)-α and minor in interleukin (IL)-1β and IL-6. (biomedcentral.com)
  • It's packed with vitamins and minerals that help reduce inflammation, promote joint health and even help protect against cancer. (davidwolfe.com)
  • Celery's alkalizing properties can help reduce inflammation, gout, and the threat of cancer. (alignlife.com)
  • The purpose of the study was to determine if luteolin could also reduce inflammation in the brain, said animal sciences professor and principal investigator Rodney Johnson. (clinicalnews.org)
  • The study leader, Professor Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. (blogspot.com)
  • The current study is to investigate whether orientin and luteolin can protect erythrocytes from oxidative injury and whether there are some differences between these two compounds with different chemical structure (Figure 1 ). (hindawi.com)
  • Again, a study has shown that increasing your intake of luteolin can reduce brain inflammation. (lifehack.org)
  • In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. (alliedacademies.org)
  • A 2017 study investigated whether luteolin could reduce inflammation and lower allergic responses in mice with these conditions. (medicalnewstoday.com)
  • A 2013 study investigated whether luteolin could reduce inflammation and protect against neurodegeneration in rodents with diabetic encephalopathy (DE). (medicalnewstoday.com)
  • In the study, rats that the investigators continuously treated with luteolin had reduced brain cell damage and improved learning and memory. (medicalnewstoday.com)
  • One Japanese study showed that luteolin can reduce the number and severity of the Japanese encephalitis virus. (naturalpedia.com)
  • In a 2010 The Journal of Nutrition study, mice that ate a diet that included luteolin had better spatial memory (e.g., how quickly they found a platform in a water maze) and less inflammation than mice that didn't get any luteolin. (eatingwell.com)
  • A study published in the Proceeding of the National Academy of Science U.S.A found that another powerful phytonutrient called luteolin prevents activation of a pathway that allows inflammation in the brain to get switched on. (naturalnews.com)
  • A study found that epigallocatechin gallate (EGCG) in green tea reduced the impact of acetaminophen's toxic impact on the liver. (medindia.net)
  • In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. (spandidos-publications.com)
  • A double study found that the oral intake of whole blueberry powder could reduce the growth and metastasis of TNBC. (canceractive.com)
  • The study is the first to indicate that luteolin increases cognitive function by acting on the microglial cells. (lifeextension.com)
  • In the study, mice whose daily diet was supplemented with 20 milligrams of luteolin had reduced inflammation in their brains. (cakehealth.com)
  • Another study found sage reduced the concentration of microbes responsible for gingivitis in the mouth making it beneficial for people who suffer from periodontal disease. (melissas.com)
  • Pretreatment of primary murine microlgia and BV-2 microglial cells with luteolin inhibited LPS-stimulated IL-6 production at both the mRNA and protein levels. (greenmedinfo.com)
  • Using electromobility shift assays, which measure the binding of transcription factors to DNA promoters, Jang eventually determined that luteolin inhibited IL-6 production by preventing activator protein-1 (AP-1) from binding the IL-6 promoter. (clinicalnews.org)
  • Combination of luteolin and lapatinib inhibited the expression of ERBB1 and ERBB2 mRNA and protein in BT474 cells. (alliedacademies.org)
  • In addition, 20 µM luteolin had a significant inhibitory effect on multi-heavy metal mixture-induced cleavage of caspase-9, caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein. (spandidos-publications.com)
  • Similar suppression for both inducible enzymes was also found with the presence of dandelion flower extract, specifically, the ethyl acetate fraction of dandelion flower extract which contained 10% luteolin and luteolin-7-O-glucoside. (springer.com)
  • Luteolin was found to upregulate miR‑384 and downregulate PTN expressions both in CRC cells and tissues. (spandidos-publications.com)
  • Zhou et al found that luteolin upregulated miR-34 expression in gastric cancer cells and upregulation of miR-34 enhanced the susceptibility of cells to luteolin ( 6 ). (spandidos-publications.com)
  • Assessment of spatial memory found increased learning and recall in older mice supplemented with luteolin compared to aged controls. (lifeextension.com)
  • In addition, we and other groups have found with animal studies that consuming a bean-based diet reduces colon cancer in azoxymethane (AOM)-induced rats and mice ( 4 - 6 ). (aacrjournals.org)
  • In fact, a research team has found that luteolin prevents activation of a pathway that allows inflammation in the brain to get switched on. (alignlife.com)
  • Luteolin suppresses the growth of colorectal cancer by regulating Wnt/β-catenin/GSK-3β signaling pathway and activating Nrf2 signaling pathway [ 14 ], and enhances the effect of tamoxifen on breast cancer by inhibiting the expression of cyclin E2 [ 15 ]. (alliedacademies.org)
  • To determine whether luteolin might have similar effects in vivo, mice were provided drinking water supplemented with luteolin for 21 days and then they were injected i.p. with LPS. (greenmedinfo.com)
  • The effects of luteolin exposure were dramatic, resulting in as much as a 90 percent drop in IL-6 production in the LPS-treated cells. (clinicalnews.org)
  • Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. (semanticscholar.org)
  • However, scientists still need to do further studies to confirm whether luteolin has similar anti-allergy effects in humans. (medicalnewstoday.com)
  • Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. (sigmaaldrich.com)
  • This has been proven time and again in several animal studies - prompting scientists to believe that luteolin can have massive anti-amnesic effects against amyloid toxicity. (naturalpedia.com)
  • Also used to strengthen your immune system as well as build energy, maintain a strong heart, reduce effects of environmental and other toxins (even chemotherapy). (life-enthusiast.com)
  • Pthalides also reduce stress hormones, one of whose effects is to cause blood vessels to constrict. (naturalnews.com)
  • Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). (nii.ac.jp)
  • First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. (spandidos-publications.com)
  • Recently, the antitumor effects of luteolin have been extensively investigated in breast and gastric cancer ( 6 ), melanoma ( 7 ), esophageal carcinoma ( 8 ), glioblastoma ( 9 ), hepatocellular carcinoma ( 10 ), placental choriocarcinoma ( 11 ) and lung adenocarcinoma ( 12 ). (spandidos-publications.com)
  • Several studies have reported the involvement of miRNAs in the effects induced by luteolin. (spandidos-publications.com)
  • Since Parsley herbal tea is not a convincing herbal drink during breastfeeding, it would be ideal to find options to reduce its effects. (pjmommy.com)
  • Dates can also reduce the risks of cancer, diabetes, and heart disease , without the toxic drug side effects. (naturalnews.com)
  • Although those studies recommended that the extracts should be taken with food to reduce the gastrointestinal side effects, the instructions on the label of the herbal tea specifically states that it should be taken on an empty stomach. (progressivehealth.com)
  • LUT pretreatment reduced miR-208b-3p expression in myocardial tissue, as compared to the I/R group. (sigmaaldrich.com)
  • Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. (semanticscholar.org)
  • Lapatinib, luteolin or the combination of both inhibited the proliferation of BT474 cells in a dose-dependent manner. (alliedacademies.org)
  • According to a 2016 review , luteolin can halt the growth of some types of cancer cells in rodents. (medicalnewstoday.com)
  • The role of luteolin in colorectal cancer (CRC) has also been investigated. (spandidos-publications.com)
  • 7 ) has shown that consuming a diet high in dry beans reduced the risk of developing advanced colorectal adenoma recurrence among participants in the Polyp Prevention Trial. (aacrjournals.org)
  • The applications are wide and include:Infections, insect bites, parasites, poisons Antiseptic for bee, wasp, hornet stings, snake bites, poison ivy or oak Insect repellent Neutralize toxicity Rashes and blemishes and wrinkles Balance gut health by supporting probiotic microbes Minimize fatigue Oral use for hygiene, reduce infection and decay Personal use for. (life-enthusiast.com)
  • Reduced toxicity results in fewer illnesses and body aches & pains. (life-enthusiast.com)
  • Further investigation revealed that luteolin is causing extensive DNA degradation in HepG2 cells. (alliedacademies.org)
  • Betaine, betalains, betacyanin, and betanin are the phytochemical compounds present in beets that help reduce liver inflammation. (medindia.net)