Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A tumor necrosis factor receptor subtype that is expressed primarily in IMMUNE SYSTEM cells. It has specificity for membrane-bound form of TUMOR NECROSIS FACTORS and mediates intracellular-signaling through TNF RECEPTOR ASSOCIATED FACTORS.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Established cell cultures that have the potential to propagate indefinitely.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A subclass of tumor necrosis family receptors that lack cell signaling domains. They bind to specific TNF RECEPTOR LIGANDS and are believed to play a modulating role in the TNF signaling pathway. Some of the decoy receptors are products of distinct genes, while others are products of ALTERNATIVE SPLICING of the MRNA for the active receptor.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Proteins prepared by recombinant DNA technology.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
A cell line derived from cultured tumor cells.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Antibodies produced by a single clone of cells.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Elements of limited time intervals, contributing to particular results or situations.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 2 to inhibit APOPTOSIS.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Intracellular signaling peptides and proteins that bind directly or indirectly to the cytoplasmic portion of TUMOR NECROSIS FACTOR RECEPTORS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Glycoproteins found on the membrane or surface of cells.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
A tumor necrosis factor receptor subtype with specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15. It is found in tissues containing LYMPHOCYTES and may play a role in regulating lymphocyte homeostasis and APOPTOSIS. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES.
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Substances that reduce or suppress INFLAMMATION.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Transport proteins that carry specific substances in the blood or across cell membranes.
A secreted tumor necrosis factor receptor family member that has specificity FAS LIGAND and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. It plays a modulating role in tumor necrosis factor signaling pathway.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
An encapsulated lymphatic organ through which venous blood filters.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The rate dynamics in chemical or physical systems.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A malignant epithelial tumor with a glandular organization.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Adherence of cells to surfaces or to other cells.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signaling and activation of MITOGEN-ACTIVATED PROTEIN KINASES.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
Transplantation between animals of different species.
Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Tumors or cancer of the COLON.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Tumors or cancer of the LIVER.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Soluble mediators of the immune response that are neither antibodies nor complement. They are produced largely, but not exclusively, by monocytes and macrophages.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
An anti-inflammatory 9-fluoro-glucocorticoid.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A signal transducing tumor necrosis factor receptor associated factor that mediates signaling from CD27 ANTIGENS; CD40 ANTIGENS; and the LYMPHOTOXIN BETA RECEPTOR. It is involved in regulation of NF-KAPPA B signaling.
A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A human cell line established from a diffuse histiocytic lymphoma (HISTIOCYTIC LYMPHOMA, DIFFUSE) and displaying many monocytic characteristics. It serves as an in vitro model for MONOCYTE and MACROPHAGE differentiation.

Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. (1/4693)

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell malignancy. A key step in HTLV-I-induced leukemigenesis is induction of abnormal T-cell growth and survival. Unlike antigen-stimulated T cells, which cease proliferation after a finite number of cell division, HTLV-I-infected T cells proliferate indefinitely (immortalized), thus facilitating occurrence of secondary genetic changes leading to malignant transformation. To explore the molecular basis of HTLV-I-induced abnormal T-cell survival, we compared the gene expression profiles of normal and HTLV-I-immortalized T cells using 'gene array'. These studies revealed a strikingly altered expression pattern of a large number of genes along with HTLV-I-mediated T-cell immortalization. Interestingly, many of these deregulated genes are involved in the control of programmed cell death or apoptosis. These findings indicate that disruption of the cellular apoptosis-regulatory network may play a role in the HTLV-I-mediated oncogenesis.  (+info)

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (2/4693)

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

Maternal second trimester serum tumor necrosis factor-alpha-soluble receptor p55 (sTNFp55) and subsequent risk of preeclampsia. (3/4693)

Preeclampsia is characterized by diffuse vascular endothelial dysfunction. Tumor necrosis factor-alpha (TNF-alpha), which plays a key role in the cytokine network responsible for immunoregulation, is also known to contribute to endothelial dysfunction and other metabolic disturbances noted in preeclampsia. Results from cross-sectional studies and one longitudinal study indicate that TNF-alpha (or its soluble receptor, sTNFp55) is increased in the peripheral circulation and amniotic fluid of women with preeclampsia as compared with normotensive women. Between December 1993 and August 1994, prediagnostic sTNFp55 concentrations (a marker of excessive TNF-alpha release) were measured in 35 women with preeclampsia and 222 normotensive women to determine whether elevations precede the clinical manifestation of the disorder. Logistic regression procedures were used to calculate maximum likelihood estimates of odds ratios and 95% confidence intervals. Mean second trimester (15-22 weeks' gestation) serum sTNFp55 concentrations, measured by enzyme-linked immunosorbent assay, were 14.4% higher in preeclamptic women than in normotensive controls (716.6 pg/ml (standard deviation 193.6) vs. 626.4 pg/ml (standard deviation 158.0); p = 0.003). The relative risk of preeclampsia increased across successively higher quintiles of sTNFp55 (odds ratios were 1.0, 1.3, 2.1, and 3.7, with the lowest quintile used as the referent; p for trend = 0.007). After adjustment for maternal age, adiposity, and parity, the relative risk between extreme quintiles was 3.3 (95% confidence interval 0.8-13.4). These findings indicate that the level of TNF-alpha in maternal circulation is increased prior to the clinical manifestation of the disorder, and they are consistent with the hypothesized role of cytokines in mediating endothelial dysfunction and the pathogenesis of preeclampsia. Further work is needed to identify modifiable risk factors for the excessive synthesis and release of TNF-alpha in pregnancy, and to assess whether lowering of TNF-alpha concentrations in pregnancy alters the incidence and severity of preeclampsia.  (+info)

Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. (4/4693)

Receptor activator of NF-kappaB (RANK) is a recently cloned member of the tumor necrosis factor receptor (TNFR) superfamily, and its function has been implicated in osteoclast differentiation and dendritic cell survival. Many of the TNFR family receptors recruit various members of the TNF receptor-associated factor (TRAF) family for transduction of their signals to NF-kappaB and c-Jun N-terminal kinase. In this study, the involvement of TRAF family members and the activation of the JNK pathway in signal transduction by RANK were investigated. TRAF1, 2, 3, 5, and 6 were found to bind RANK in vitro. Association of RANK with each of these TRAF proteins was also detected in vivo. Expression of RANK in cultured cells also induced the activation of JNK, which was blocked by a dominant-negative form of JNK. Furthermore, by employing various C-terminal deletion mutants of RANK, the regions responsible for TRAF interaction and JNK activation were identified. TRAF5 was determined to bind to the C-terminal 11 amino acids and the other TRAF members to a region N-terminal to the TRAF5 binding site. The domain responsible for JNK activation was localized to the same region where TRAF1, 2, 3, and 6 bound, which suggests that these TRAF molecules might mediate the RANK-induced JNK activation.  (+info)

Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration. (5/4693)

Hepatic cytochromes P-450 (CYP) are well characterized drug and xenobiotic metabolizing enzymes that are extensively regulated by genetic and environmental factors. Inflammatory mediators, including interleukins (ILs), interferons (IFNs), and tumor necrosis factor-alpha (TNF-alpha), have been shown to down-regulate several CYP isoforms; however, elucidation of the inflammatory mediators that are responsible for specific CYP down-regulation is difficult. The purpose of this experiment was to evaluate the role endogenous TNF-alpha plays in the regulation of liver CYP expression after endotoxin administration. Mice deficient in the p55 and p75 TNF receptors and wild-type mice were given Gram-negative bacterial lipopolysaccharide (LPS) and killed 24 h after administration. CYP analysis indicates that LPS decreases CYP1A, CYP2B, CYP3A, and CYP4A independently of TNF-alpha. CYP2D9 and CYP2E1 activities show differential responses to LPS between wild-type and TNF p55/p75 receptor knockout mice, indicating the down-regulation of CYP2D9 and CYP2E1 is differentially modulated by TNF-alpha expression. Furthermore, TNF-alpha appears to affect the constitutive expression of CYP2D9 and CYP2E1. To date, this is the first evidence suggesting that a proinflammatory cytokine is involved in the constitutive regulation of drug-metabolizing enzymes.  (+info)

A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. (6/4693)

We have shown previously (J. A. Houghton et al., Proc. Natl. Acad. Sci. USA, 94: 8144-8149, 1997) that thymineless death in thymidylate synthase-deficient (TS-) colon carcinoma cells is mediated via Fas/FasL interactions after deoxythymidine (dThd) deprivation, and that Fas-dependent sensitivity of human colon carcinoma cell lines may be dependent upon the level of Fas expressed. The objective of this study was to elucidate whether a Fas-dependent component exists in 5-fluorouracil (FUra)/leucovorin (LV)-induced cytotoxicity of colon carcinoma cells, and whether this may be potentiated by IFN-gamma-induced elevation in Fas expression, using the HT29 cell line as a model. The cytotoxic activity of FUra/LV was inhibited by dThd in HT29 cells and also, in part, by NOK-1+NOK-2 MoAbs that prevent Fas/FasL interactions. FUra/LV-induced cytotoxicity was significantly potentiated by IFN-gamma, reversed by exposure to NOK-1+NOK-2 antibodies, and correlated with a 4-fold induction of Fas expression in the presence of IFN-gamma and significant elevation in expression of FasL. Using five additional human colon carcinoma cell lines, FUra/LV-induced cytotoxicity was dThd-dependent in GC3/c1, VRC5/c1, and Caco2 but not in HCT8 or HCT116 cells. Like HT29 cells, this cytotoxicity was potentiated by IFN-gamma in GC3/c1 and VRC5/c1 but not in Caco2, which fails to express Fas, nor in HCT8 and HCT116, in which no dThd-dependent FUra-induced cytotoxicity was demonstrated. Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur.  (+info)

Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (7/4693)

Among members of the tumor necrosis factor receptor (TNFR) superfamily, 4-1BB, CD27, and glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) share a striking homology in the cytoplasmic domain. Here we report the identification of a new member, activation-inducible TNFR family member (AITR), which belongs to this subfamily, and its ligand. The receptor is expressed in lymph node and peripheral blood leukocytes, and its expression is up-regulated in human peripheral mononuclear cells mainly after stimulation with anti-CD3/CD28 monoclonal antibodies or phorbol 12-myristate 13-acetate/ionomycin. AITR associates with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRAF3, and induces nuclear factor (NF)-kappaB activation via TRAF2. The ligand for AITR (AITRL) was found to be an undescribed member of the TNF family, which is expressed in endothelial cells. Thus, AITR and AITRL seem to be important for interactions between activated T lymphocytes and endothelial cells.  (+info)

In vitro inhibition of binding of tumor necrosis factor (TNF)-alpha by monoclonal antibody to TNF receptor on glioma cell and monocyte. (8/4693)

The use of monoclonal antibodies to the tumor necrosis factor (TNF) receptors, the TNF-p55 receptor (TNF-p55R) and the TNF-p75 receptor (TNF-p75R), was evaluated to reduce the effects of TNF caused by binding to TNF-p75R. Competitive binding of anti-TNF-p55R (mAbp55R) and anti-TNF-p75R monoclonal antibodies (mAbp75R) with iodine-125-labeled TNF-alpha to GL-9 glioma cells and U937 histiocytic lymphoma cells was evaluated. The effects of mAbp55R and mAbp75R on the growth suppression by TNF-alpha of GL-9 cells and TNF-alpha production in U937 cells were also examined. mAbp75R bound to U937 cells competitively with TNF-alpha and suppressed TNF-alpha production by U937, but had no effect on the growth inhibition of GL-9 human glioma cell by TNF-alpha in vitro. These findings suggest that co-administration of TNF-p75R antagonist with TNF-alpha may decrease the toxicity of TNF-alpha administration resulting in a better therapeutic result.  (+info)

MarketResearchReports.biz has recently announced the addition of a market study Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Pipeline Review, H2 2016 , is a comparative analysis of the global market.. Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Pipeline Review, H2 2016. Summary. Global Markets Directs, Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Pipeline Review, H2 2016, provides in depth analysis on Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted pipeline therapeutics.. The report provides comprehensive information on the Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or ...
Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I or p55 or p60 or CD120a - Market research report and industry analysis - 12355963
[65 Pages Report] Check for Discount on Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Pipeline Review, H1 2018 report by Global Markets Direct. Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or...
|p|Tumor necrosis factor receptor superfamily, member 1A is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-kB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease.|/p|
TY - JOUR. T1 - Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for eiger signaling. AU - Kanda, Hiroshi. AU - Igaki, Tatsushi. AU - Kanuka, Hirotaka. AU - Yagi, Takeshi. AU - Miura, Masayuki. PY - 2002/8/9. Y1 - 2002/8/9. N2 - We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development. The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference. In addition, Wengen and Eiger physically interacted with each other through their TNFR homology domain and TNF homology domain, respectively. These results suggest that Wengen can act as a component of a ...
Short gene description: Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen)(Etanercept) [Contains Tumor necrosis factor receptor superfamily member 1b, membrane form;Tumor necrosis factor-binding protein 2(TBPII)(TBP-2)] [Source:UniProtKB/Swiss-Prot;Acc:P20333 ...
HTF Market Intelligence released a new research report of 41 pages on title Tumor Necrosis Factor Receptor Superfamily Member 6 (Apo 1 Antigen or Apoptosis Mediating Surface Antigen FAS or FASLG Receptor or TNFRSF6 or CD95 or FAS) - Pipeline Review, H1 2017 with detailed analysis, forecast and strategies. The study covers key regions and important players such as KAHR medical Ltd, Silence Therapeutics Plc
Tnfrsf1a (untagged) - Mouse tumor necrosis factor receptor superfamily, member 1a (cDNA clone MGC:6117 IMAGE:3585060), (10ug), 10 µg.
TNF-alpha and lymphotoxin alpha (TNF-beta) are pleiotropic cytokines with regulatory functions in inflammatory reactions and T cell activation. Natural TNF inhibitors such as soluble TNF-binding proteins, i.e. TNFsR55 and TNFsR75, are shed from white blood cells and probably other cells. These naturally occurring inhibitors of TNF are shown to be 10 times less effective than the bivalent antagonist of TNF, recombinant soluble TNF receptor p55-human gamma 3 fusion protein (rsTNFR-p55h gamma 3), in controlling the release of prostaglandin E2 (PGE2) and collagenase by fibroblasts, as well as in controlling T cell proliferation. In order to block the action of rhTNF-alpha added to fibroblasts, a fivefold excess of rsTNFR-p55h gamma 3 was sufficient, but concentrations of a hundred to a thousand times higher were required to obtain a significant inhibition of T cell activation. This concentration appears to be required to block membrane-bound TNF-alpha on peripheral blood mononuclear cells
RPB499Hu01, CD120A; P55; TBP1; FPF; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; P55-R; P60; Tumor necrosis factor receptor 1; Tumor necrosis factor-binding protein 1 | Products for research use only!
TY - JOUR. T1 - Ligand-induced formation of p55 and p75 tumor necrosis factor receptor heterocomplexes on intact cells. AU - Pinckard, J. Keith. AU - Sheehan, Kathleen C F. AU - Schreiber, Robert D.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1997/4/18. Y1 - 1997/4/18. N2 - The p55 and p75 tumor necrosis factor receptors are known to mediate their effects on cells through distinct signaling pathways. Under certain circumstances, the two classes of TNF receptors cooperate with each another to produce enhanced cellular responses. The only molecular mechanism proposed thus far to explain this effect is the process of ligand passing, whereby TNF is concentrated at cell surfaces by binding to p75 and then following dissociation from this receptor class binds with high efficiency to p55. Using the in vivo model of TNF-induced TNF receptor shedding we have uncovered a novel ligand-dependent interaction of the two TNF receptors that occurs upon exposure of cells to TNF. ...
To examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. This longitudinal observational study examined participants aged ≥18 years recruited from ,20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history. Linear regression was used to estimate annual change in estimated glomerular filtration rate (eGFR) for increasing sTNFR1, and Cox proportional hazards were used to estimate the hazard ratio (HR) and 95% CI for developing a combined renal outcome (first of a ≥30% decline in eGFR with a follow-up eGFR ,60 mL/min/1.73 m2, progression to renal replacement therapy, or renal death) for increasing sTNFR1. Over a median of 3 years, participants with diabetes (n= 194) in the highest ...
RA is a multigene disorder with genetic polymorphisms influencing a wide spectrum of its clinical presentations. Disease progression, pattern of joint disease, and extra-articular manifestations are highly variable.6 Several data suggested also that RA is histopathologically heterogeneous.2,3 Histological analyses in this and in previous studies showed that most rheumatoid synovia are characterised by differences in the density of the diffuse infiltrate of mononuclear cells, and lack any further specific microanatomical organisation. Such synovia may be classified as diffuse synovitis.3 In about one third of RA synovia, categorised as follicular synovitis, the formation of lymphoid conglomerates was demonstrated.2,3 The presence of lymphoid follicles was associated with a greater degree of immunological activation, and greater potential for joint tissue destruction.2-5 All these findings support the concept of the clinical and histological heterogeneity of RA.. Mononuclear cells infiltrating the ...
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014 ...
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial
Research proven purified goat polyclonal TRAIL R3, DcR 1 or CD263 antibody. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis. Designed for immunohistochemistry, western blotting, ELISA and related apllications. IHC image in product description.
The TNFRSF11A gene encodes a member of the TNF receptor family and is therefore involved in regulation of immunen processes. Mutations cause autosomal recessive juvenile Paget disease, osteopetrosis, and dominant familial expansile osteolysis.. ...
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Vaccinia virus (VACV), the smallpox vaccine, encodes many proteins that subvert the host immune response. One of these, cytokine response modifier E (CrmE), is secreted by infected cells and protects these cells from apoptotic challenge by tumour necrosis factor alpha (TNFalpha). We have expressed recombinant CrmE from VACV strain Lister in Escherichia coli, shown that the purified protein is monomeric in solution and competent to bind TNFalpha, and solved the structure to 2.0 A resolution. This is the first structure of a virus-encoded tumour necrosis factor receptor (TNFR). CrmE shares significant sequence similarity with mammalian type 2 TNF receptors (TNFSFR1B, p75; TNFR type 2). The structure confirms that CrmE adopts the canonical TNFR fold but only one of the two ligand-binding loops of TNFRSF1A is conserved in CrmE, suggesting a mechanism for the higher affinity of poxvirus TNFRs for TNFalpha over lymphotoxin-alpha. The roles of dimerisation and pre-ligand-assembly domains (PLADs) in poxvirus
TY - JOUR. T1 - 10-Year associations between tumor necrosis factor receptors 1 and 2 and cardiovascular events in patients with stable coronary heart disease. T2 - A CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients with Ischemic Heart Disease) trial substudy. AU - Carlsson, Axel C.. AU - Ruge, Toralph. AU - Kjøller, Erik. AU - Hilden, Jørgen. AU - Kolmos, Hans Jørn. AU - Sajadieh, Ahmad. AU - Kastrup, Jens. AU - Jensen, Gorm Boje. AU - Larsson, Anders. AU - Nowak, Christoph. AU - Jakobsen, Janus Christian. AU - Winkel, Per. AU - Gluud, Christian. AU - Ärnlöv, Johan. N1 - © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.. PY - 2018/4/23. Y1 - 2018/4/23. N2 - BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease.METHODS AND RESULTS: CLARICOR (Effect of ...
Nine different IgG fusion proteins and one non-fusion protein, all containing sequences from the extracellular domain of either of two human TNF receptors, were compared for their ability to bind and inhibit human TNF-alpha or TNF-beta. The fusion proteins differed with respect to TNF receptor type (p55 or p75 TNF receptor), receptor valency (one, two or four receptor domains per molecule), the presence or absence of a CH1 domain in the IgG constant region, and the proportion of the extracellular domain included in the construct. In vitro TNF binding assays and cytotoxicity assays indicated that, of the constructs that bound TNF, the greatest difference in affinity and neutralizing capability was between monovalent and bivalent receptor constructs. Differences were also noted between tetravalent and bivalent versions of p55 fusion proteins, as well as between a p75 fusion protein comprising the complete extracellular domain and one lacking the C-terminal 53 amino acids of the extracellular domain. p55
To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, the effects of ovariectomy were explored in six-month-old transgenic mice expressing high blood levels of a soluble TNF receptor type I (sTNFR1)-FcIgG3 fusion protein, which neutralizes TNF alpha, and in their nontransgenic littermates used as controls. These transgenic mice were identical to control mice in bone mass (evaluated by bone mineral density and content) and strength. 12 weeks after ovariectomy, the decrease in bone mass and increase in osteocalcin (marker of bone turnover) found in control mice were not observed in transgenic mice, which were not different from sham-operated mice, transgenic or not. This observation suggests a critical role for TNF alpha in the pathogenesis of bone loss induced by estrogen deficiency, a common cause of morbidity in postmenopausal women. ...
TNFRSF9 - TNFRSF9 (untagged)-Human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9) available for purchase from OriGene - Your Gene Company.
TY - JOUR. T1 - Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. AU - Fang, Lei. AU - Adkins, Becky. AU - Deyev, Vadim. AU - Podack, Eckhard R.. PY - 2008/5/12. Y1 - 2008/5/12. N2 - We identify the tumor necrosis factor receptor superfamily 25 (TNFRSF25)/TNFSF15 pair as critical trigger for allergic lung inflammation, which is a cardinal feature of asthma. TNFRSF25 (TNFR25) signals are required to exert T helper cell 2 (Th2) effector function in Th2-polarized CD4 cells and co-stimulate interleukin (IL)-13 production by glycosphingolipid-activated NKT cells. In vivo, antibody blockade of TNFSF15 (TL1A), which is the ligand for TNFR25, inhibits lung inflammation and production of Th2 cytokines such as IL-13, even when administered days after airway antigen exposure. Similarly, blockade of TNFR25 by a dominant-negative (DN) transgene, DN TNFR25, confers resistance to lung inflammation in mice. Allergic lung inflammation - resistant, ...
A novel member of the tumor necrosis factor (TNF) cytokine family, designated TRANCE, was cloned during a search for apoptosis-regulatory genes using a somatic cell genetic approach in T cell hybridomas. The TRANCE gene encodes a type II membrane protein of 316 amino acids with a predicted molecular mass of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL, and TNF. TRANCE is an immediate early gene up-regulated by TCR stimulation and is controlled by calcineurin-regulated transcription factors. TRANCE is most highly expressed in thymus and lymph nodes but not in nonlymphoid tissues and is abundantly expressed in T cells but not in B cells. Cross-hybridization of the mouse cDNA to a human thymus library yielded the human homolog, which encodes a protein 83% identical to the mouse ectodomain. Human TRANCE was mapped to chromosome 13q14 while mouse TRANCE was located to the portion of mouse chromosome 14 syntenic with human chromosome 13q14. A recombinant soluble form of
Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described. GRCh38: Ensembl release 89: ENSG00000127863 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000060548 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19. Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). Isolation of novel and known genes from a human fetal cochlear ...
Clone mCD30.1 recognizes mouse CD30, a 105 kDa type I transmembrane glycoprotein, also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8). CD30 is a cell membrane protein. The cytoplasmic tail has been shown to interact with tumor necrosis factor receptor-associated factor 5 (TRAF5), TRAF1, TRAF2, and TRAF3. CD30 is expressed on the cell surface of activated T, B, and NK cells, and monocytes. The ligand for CD30 is CD153. CD153 co-stimulates peripheral blood T-cell proliferation or apoptosis, induces surface expression of activation and adhesion molecules (e.g., CD54, CD80, and CD86), and induces cytokine (e.g., interleukin 2, tumor necrosis factor, and interferon γ) secretion. Deletion of the murine CD30 gene revealed that CD30 may have a unique role in negative thymic selection following exposure to antigen. | USA
View mouse Tnfrsf13b Chr11:61126755-61149372 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
View mouse Tnfrsf18 Chr4:156026164-156028895 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...
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WORKLIST ENTRIES (1): TNFACTORR14 View alignment Tumour necrosis factor receptor 14 signature Type of fingerprint: COMPOUND with 4 elements Links: PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3 PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6 PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9 PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12 PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01966 TNFACTORR16 PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19 PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25 PRINTS; PR01973 TNFACTORR27 PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B MIM; 602746 Creation date 23-JUN-2009 1. ARMITAGE, R. Tumor necrosis factor receptor superfamily members and their ligands. CURR.OPIN.IMMUNOL. 6 407-413 (1994). 2. BANNER D., DARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C., LOETSCHER, H. AND LESSLAUER, W. Crystal structure of the ...
The TNF receptor superfamily members are all type I membrane glycoproteins with typical homology in the extracellular domain of variable numbers of cysteine-rich repeats (overall homologies, 25% to 30%). In contrast, the TNF ligand superfamily members (with the exception of LT alpha) are type II membrane glycoproteins with homology to TNF in the extracellular domain (overall homologies, 20%). TNF and LT alpha are trimeric proteins and are composed of beta-strands forming a beta-jellyroll. The homology of the beta-strand regions for the TNF ligand superfamily members suggest a similar beta-sandwich structure and possible trimeric or multimeric complex formation for most or all members. A genetic linkage, as evidence for evolutionary relatedness, is found by chromosomal cluster of TNFR p80, CD30, 4-1BB, and OX40 for 1p36; TNFR p60, TNFR-RP, and CD27 for 12p13; TNF, LT alpha, and LT beta for 6 (MHC locus); CD27L and 4-1BBL for 19p13; and FASL and OX40L for 1q25. Of the TNF ligand superfamily, TNF, ...
Objective: To investigate the possible influence of tumour necrosis factoralpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody ...
Tumor necrosis factor receptor superfamily member 14(TNFRSF14), also known as HVEM, is a protein that in humans is encoded by the TNFRSF14 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. It is mapped to 1p36.32. HVEM plays an important role in HSV pathogenesis because it enhanced the entry of several wildtype HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T cells. HVEM and BTLA which are form a bidirectional signaling pathway can regulate cell survival and inhibitory responses between interacting cells. HVEM as an important orchestrator of mucosal immunity integrates signals from innate lymphocytes to induce optimal epithelial Stat3 activation, which indicated that targeting HVEM with agonists could improve host defense.
OBJECTIVE: Circulating soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) are associated with chronic kidney disease (CKD) progression in patients with CKD or diabetes, and with higher mortality. However, data in patients with end-stage renal disease are scarce. Therefore, we analyzed serum levels of sTNFR1 and sTNFR2 and investigated their association with inflammatory markers and mortality in dialysis patients.. RESEARCH DESIGN AND METHODS: This was a longitudinal cohort study of 207 prevalent patients (median age 66 years, 56% men) undergoing hemodialysis in Stockholm, Sweden. Demographics, clinical characteristics, including comorbidities and laboratory data, were obtained at baseline, together with prospective follow-up for mortality.. RESULTS: The median sTNFR1 and sTNFR2 levels were 17,680 ng/l [95% confidence interval (CI) 17,023-18,337] and 24,450 ng/l (95% CI 23,721-25,179), respectively. During a follow-up of 31 months (interquartile range, 21-38), 77 patients died. ...
Glucocorticoid-induced TNFR family related protein (GITR, CD357 or TNFRSF18) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). Like other T cell co-stimulatory TNFR family members, GITR utilizes multiple oligomerization states to regulate the initiation of downstream signaling during T cell activation by antigen presenting cells (APCs). The formation of receptor superclusters, comprised of two or more trimeric molecules, has been defined for multiple TNFRs as a means of regulating downstream signal amplification. For co-stimulatory TNFRs, like GITR, CD137 and OX40, signaling outcomes in T cells are primarily mediated via the NFκB pathway that promotes cell survival and effector cell activities in response to suboptimal T cell receptor (TCR) stimulation. It has been hypothesized that the manipulation of the oligomeric states of co-stimulatory TNFRs using antibodies may have therapeutic utility in enhancing the activity of tumor-reactive T cells, either as single agents or ...
specificalPrinciple of the assay: mouse TNFRSF14 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from rat specific for TNFRSF14 has been precoated onto 96-well plates. Standards(CHO, Q29-V207) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for TNFRSF14 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the mouse TNFRSF14 amount of sample captured in plate. Background: Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a protein that in humans is encoded by the TNFRSF14 gene. The protein encoded ...
Clone REA499 recognizes the human and mouse CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)-induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on natural killer (NK), T, and B cell populations. In human and mice, the majority of CD4+ and CD8+ naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27+ B cells display all the functional and phenotypic characteristics of memory cells. Additional
CD40 Antibody is a Rabbit Polyclonal antibody against CD40. This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune
Somatic mutations of the tumor suppressor tumor necrosis factor receptor superfamily member 14 (HVEM, encoded by TNFRSF14), which frequently occur in follicular lymphomas (FL), disrupt the interaction between HVEM and the immune checkpoint protein B and T lymphocyte associated (BTLA), resulting in the inhibition of T-cell immune responses. To elucidate the role of HVEM in germinal center (GC) lymphomagenesis, Boice, Salloum, Mourcin, and colleagues evaluated the interaction between HVEM and BTLA in FLs. Genomic and immunohistochemical analyses of human FLs identified HVEM mutations in 28% (40 of 141) of patient samples and the mutually exclusive loss of either HVEM or BTLA expression in 73% (145 of 198) of patient samples. Depletion of B cell-specific Hvem or Btla in a genetically engineered mouse model of FL resulted in enhanced lymphomagenesis in Hvem-deficient mice and Btla-deficient mice compared to control mice. Further, the morphology and activated status of the B-cell receptor (BCR) ...
TY - JOUR. T1 - Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function. AU - Fortin, Shannon P.. AU - Ennis, Matthew J.. AU - Savitch, Benjamin A.. AU - Carpentieri, David. AU - McDonough, Wendy S.. AU - Winkles, Jeffrey A.. AU - Loftus, Joseph C.. AU - Kingsley, Christopher. AU - Hostetter, Galen. AU - Tran, Nhan L.. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and significant technical advances in surgical and radiation treatment, the impact on clinical outcome for patients with malignant gliomas is disappointing. We have previously shown that tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell survival via binding to the Fn14 receptor, activation of the NF-κB pathway, and upregulation of BCL-X L gene expression. Here, we show that TWEAK treatment of ...
Levels of soluble tumour necrosis factor receptors (sTNFRs) are elevated in the circulation of patients with rheumatoid arthritis (RA). Although these receptors can act as natural inhibitors of tumour necrosis factor-α, levels of sTNFRs in RA appear to be insufficient to prevent tumour necrosis factor-α induced inflammation. The factors that regulate circulating levels of sTNFRs are unclear, but polymorphisms in the tumour necrosis factor receptor genes may play a role. We investigated the relationship between polymorphisms in the tumour necrosis factor receptor I (TNF-RI) and II (TNF-RII) genes and levels of sTNFRs in two groups of Caucasian RA patients: one with early (disease duration ≤2 years; n = 103) and one with established disease (disease duration ≥5 years; n = 151). PCR restriction fragment length polymorphism analysis was used to genotype patients for the A36G polymorphism in the TNF-RI gene and the T676G polymorphism in TNF-RII. Levels of sTNFRs were measured using ELISA. We also
Angiogenesis, the formation of new blood vessels from preexisting vasculature, is crucial for primary tumor growth and metastasis (1, 2, 3) . Tumor cells stimulate angiogenesis by producing polypeptide factors that act in a paracrine manner to promote endothelial cell proliferation, migration, and ultimately, vessel assembly and stabilization (1, 2, 3) . One of these proangiogenic polypeptides, vascular endothelial cell growth factor, is now recognized as an important regulator of both normal vessel growth and tumor neovascularization, and indeed a humanized anti-vascular endothelial growth factor monoclonal antibody has been approved for use in the treatment of metastatic colorectal cancer patients (4) . Nevertheless, it is likely that other tumor-derived angiogenic factors also function as key regulators of tumor neovascularization, and the identification and characterization of these factors, their cell surface receptors, and their intracellular signaling pathways may result in the ...
We have shown that high plasma levels of sTNFR1 during the acute phase are associated with long-term all-cause mortality and cardiovascular death in HF following AMI. Previously, Rauchhaus et al. (7) reported that sTNF-R1 emerged among all cytokine parameters as the strongest and most accurate prognostic marker in chronic HF. Recently, Valgimigli et al. (8) reported that among several inflammatory markers, sTNF-R1 remained the only independent predictor of death and HF after MI. The present study confirms and extends these findings, evaluating the prognostic significance of raised plasma sTNF-R1 in HF both in the acute phase and during follow-up. In fact, we show that non-survivors have raised plasma levels of sTNFR1 compared with survivors not only at baseline but at all time points during the observation period. Importantly, we show that sTNF-R1 has predictive power independent of other well-established risk markers such as N-BNP and hsCRP (9), possibly reflecting that we are focusing on a ...
Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations : comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia
A Tumor Necrosis Factor Family member that is released by activated Lymphocytes. Soluble lymphotoxin is specific for Tumor Necrosis Factor Receptor Type I; Tumor Necrosis Factor Receptor Type II; and Tumor Necrosis Factor Receptor Superfamily, Member 14. Lymphotoxin-alpha can form a Membrane-bound heterodimer with Lymphotoxin-beta that has specificity for the Lymphotoxin beta Receptor ...
Global Tumor Necrosis Factor Receptor Superfamily Member 1A Market Research (2015-2019) and Future Forecast (2020-2025) includes market share, market research report, market trade, market prices, market geography trend and market forecast
TY - JOUR. T1 - Cloning and characterization of cDNAs for two distinct tumor necrosis factor receptor superfamily genes from Japanese flounder Paralichthys olivaceus. AU - Park, Chan Il. AU - Kurobe, Tomofumi. AU - Hirono, Ikuo. AU - Aoki, Takashi. PY - 2003/5/1. Y1 - 2003/5/1. N2 - Tumor necrosis factor receptor (TNFR) superfamily regulates diverse biologic functions, including cell proliferation, differentiation, and survival, in addition to providing costimulatory signals for programmed cell death or apoptosis. In this study, cDNA fragments for two distinct TNFR homologues were obtained from a Japanese flounder, Paralichthys olivaceus, cDNA library. Full-length cDNAs of TNFR-1 and TNFR-2 homologues were obtained by using these cDNA fragments as probes. The cDNA for the Japanese flounder TNFR-1 homologue predicts a peptide of 395 amino acids that is 35% identical to the extracellular region of mouse TNFR-1, whereas the cDNA of the Japanese flounder TNFR-2 homologue predicts a peptide of 483 ...
OBJECTIVE: To determine whether selective blockade of tumor necrosis factor receptor I (TNFRI) affects spontaneous proinflammatory cytokine and chemokine production in ex vivo-cultured human rheumatoid arthritis synovial membrane mononuclear cells (MNCs) and to compare this response to that of TNF
Tumor Necrosis Factor Receptor I (TNFRI) is a 55 kDa pleiotropic cytokine that is considered a primary modifier of the inflammatory and immune reactions of
0018] The soluble TNFR polypeptides or fragments of the invention may be fused with a second polypeptide to form a chimeric protein. The second polypeptide may promote the spontaneous formation by the chimeric protein of a dimer, trimer or higher order muimer that is capable of binding a TNFα and/or LTα molecule and preventing it from binding to cell-bound receptors. Chimeric proteins used as antagonists include, for example, molecules derived from an antibody molecule and a TNFR. Such molecules are referred to herein as TNFR-Ig fusion proteins. A preferred TNFR-Ig fusion protein suitable for treating diseases in humans and other mammals is recombinant TNFR:Fc, a term which as used herein refers to etanercept, which is a dimer of two molecules of the extracellular portion of the p75 TNFα receptor, each molecule consisting of a 235 amino acid TNFR-derived polypeptide that is fused to a 232 amino acid Fc portion of human IgG1. Etanercept is currently sold by Immunex Corporation under the ...
0018] The soluble TNFR polypeptides or fragments of the invention may be fused with a second polypeptide to form a chimeric protein. The second polypeptide may promote the spontaneous formation by the chimeric protein of a dimer, trimer or higher order muimer that is capable of binding a TNFα and/or LTα molecule and preventing it from binding to cell-bound receptors. Chimeric proteins used as antagonists include, for example, molecules derived from an antibody molecule and a TNFR. Such molecules are referred to herein as TNFR-Ig fusion proteins. A preferred TNFR-Ig fusion protein suitable for treating diseases in humans and other mammals is recombinant TNFR:Fc, a term which as used herein refers to etanercept, which is a dimer of two molecules of the extracellular portion of the p75 TNFα receptor, each molecule consisting of a 235 amino acid TNFR-derived polypeptide that is fused to a 232 amino acid Fc portion of human IgG1. Etanercept is currently sold by Immunex Corporation under the ...
Utilizado en el tratamiento de la artritis reumatoide y la reducción de los efectos adversos del factor de necrosis tumoral (TNF). TNF es una citoquina natural que interviene en inflamatoria normal y la respuesta inmune. Los niveles elevados de TNF se encuentran en los tejidos y fluidos de los pacientes con artritis reumatoide, artritis psoriásica, la espondilitis anquilosante (AS), y psoriasis en placa. Etanercept se une específicamente al factor de necrosis tumoral (TNF) y bloquea su interacción con los receptores de la superficie celular TNF ...
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) or glucocorticoid-induced TNFR-related protein (GITR) is a protein that in humans is encoded by the TNFRSF18 gene. GITR is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. TNFRSF18 is a member of the tumor necrosis factor receptor (TNF-R) superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25+/CD4+ regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the ...
Comparison of Drug and Cell-Based Delivery: Engineered Adult Mesenchymal Stem Cells Expressing Soluble Tumor Necrosis Factor Receptor II Prevent Arthritis in Mouse and Rat Animal Models Tumor necrosis factor-α (TNFα) is a cytokine that mediates normal homeostatic mammalian processes (Schaible et al and Wajant et al) but has been linked to the systemic autoimmune disease Rheumatoid Arthritis (RA), where a TNFα induced cytokine cascade causes inflammation and joint destruction. Blocking TNFα function would therefore seem a viable means to treat RA. Etanercept, a TNF receptor (TNFR) linked to the immunoglobin Fc fragment and two monoclonal antibodies, infliximab and adalimumab are three TNFα inhibitors approved in the United States (Mazza et al), while TNFα blockers certolizumab pegol and golimumab are also utilised (Wallis and Scallon et al). However, the necessity for systemic delivery leads to certain unwanted side-effects, and so site-specific drug action is being sought after. To this end, in
Apoptosis or programmed cell destruction is a key regulator of tissue homeostasis. An imbalance between cell death and proliferation may result in tumor formation. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates the extrinsic apoptotic pathway through the engagement of the proapoptotic death receptor 4 (DR4, TNFRSF10A, TRAILR-1), a member of the tumor necrosis factor receptor superfamily. DR4 consists of two extracellular cysteine-rich, ligand-binding pseudorepeats (50s and 90s loops), one single transmembrane helix as well as the apoptosis-triggering cytoplasmic death domain. Suppression of cell death signaling due to detrimental alterations in DR4 involves a deregulated cell proliferation and predisposes to cancer (1-6).. Immunohistochemical studies have shown extensive expression of DR4 both in sporadic and hereditary colorectal neoplasms together with a higher degree of apoptosis, suggesting neoplastic colorectal cells to be prone to TRAIL-induced apoptosis (5, ...
Title:Insulin-Sensiting Effects of Tumor Necrosis Factor Alpha Inhibitors in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. VOLUME: 13 ISSUE: 3. Author(s):Christian Leporini*, Emilio Russo, Salvatore D`Angelo, Franco Arturi, Giovanni Tripepi, Rosario Peluso, Rosa Daniela Grembiale, Ignazio Olivieri, Giovambattista De Sarro and Francesco Ursini. Affiliation:Department of Health Sciences, University of Catanzaro , Department of Health Sciences, University of Catanzaro , Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Department of Health Sciences, University of Catanzaro , CNRIBIM, National Research Council-Institute of Biomedicine, Reggio Calabria, Department of Clinical Medicine and Surgery - Rheumatology Research Unit - Federico II University, Naples, Department of Health Sciences, University of Catanzaro , Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of ...
Fingerprint Dive into the research topics of The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity. Together they form a unique fingerprint. ...
Tumor necrosis factor alpha (TNF-α) is important in resistance to various microorganisms and provides signals to the target cells through two different receptors, TNF-α receptor I (TNFRI) (p55 receptor) and TNFRII (p75 receptor). To delineate the significance of the two different signaling pathways in resisting infections with extracellular bacteria, we examined the resistance of mice to Streptococcus pneumoniae (serotype 6B). TNF-α needs to be present early in infections, since one injection of wild-type mice with anti-TNF-α leads to an increased susceptibility of these mice to S. pneumoniae. TNF-α signaling through the p55 receptor (but not the p75 receptor) is crucial in resisting S. pneumoniae infections, because intraperitoneal injection of 100 CFU/mouse killed p55-deficient mice by day 2 of infection, whereas 1,000,000 CFU/mouse was needed to kill half of the control mice. p55-deficient mice do not show evidence of a deficient acute- phase response. All three types of mice (p55 ...
This study was conducted to investigate therapeutic value of a soluble tumor necrosis factor-alpha (TNF-alpha) receptor, etanercept, in a rat model of endotoxin-induced uveitis (EIU). Forty-two inbred male Lewis rats were divided into seven equal groups. 200 mug of Escherichia coli 055:1355 lipopolysaccharide, (LPS) was injected in one hind footpad of the Groups 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received subcutaneous etanercept 24 hr prior to LPS injection at a dose of 0(.)4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uvetis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized. Neutrophil leukocytes, CD8 +, CD4 +, and CD45RO + cells in the anterior uveal tissue were counted either after hematoxylin-eosin or monoclonal antibody staining. TNF-alpha. levels were also measured in the aqueous humor samples by an ELISA method. Etanercept treatment significantly improved ...
Studies of tumour necrosis factor receptor-1 in tumour necrosis factor receptor associated periodic sysndrome (TRAPS): United Kingdom
Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine that regulates cell growth, migration, and survival principally through a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14). However, its physiological roles in bone are largely unknown. We herein report various effects of TWEAK on mouse osteoblastic MC3T3-E1 cells. MC3T3-E1 cells expressed Fn14 and produced RANTES (regulated upon activation, healthy T cell expressed and secreted) upon TWEAK stimulation through PI3K-Akt, but not nuclear factor-κB (NF-κB), pathway. In addition, TWEAK inhibited bone morphogenetic protein (BMP)-2-induced expression of osteoblast differentiation markers such as alkaline phosphatase through mitogen-activated protein kinase (MAPK) Erk pathway. Furthermore, TWEAK upregulated RANKL (receptor activation of NF-κB ligand) expression through MAPK Erk pathway in MC3T3-E1 cells. All these effects of TWEAK on MC3T3-E1 cells were abolished by
PE anti-mouse CD120a (TNF R Type I/p55) Antibody - CD120a is a 55 kD Type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type I (TNFRI) or p55.
Belantamab mafodotin, also known as GSK2857916, is an investigational anti-TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)], humanized monoclonal antibody conjugated, on an average of 4 cysteinyl, to monomethyl auristatin F (MMAF), via a noncleavable maleimidocaproyl (mc) linker.
Tumor necrosis factors (TNF) alpha and beta are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. During bacterial infection of the bloodstream (sepsis), TNF-alpha induction by bacterial endotoxin is thought to be a major factor contributing to the cardiovascular collapse and critical organ failure that can develop. Despite antibiotic therapy, these consequences of sepsis continue to have a high mortality rate in humans. Here we describe a potent TNF antagonist, a TNF receptor (TNFR) immunoadhesin, constructed by gene fusion of the extracellular portion of human type 1 TNFR with the constant domains of human IgG heavy chain (TNFR-IgG). When expressed in transfected human cells, TNFR-IgG is secreted as a disulfide-bonded homodimer. Purified TNFR-IgG binds to both TNF-alpha and TNF-beta and exhibits 6- to 8-fold higher affinity for TNF-alpha than cell surface or soluble TNF receptors. In vitro, TNFR-IgG blocks completely the cytolytic ...
Sarcoidosis is a systemic granulomatous disease of unknown aetiology that most commonly affects the lungs. Although elevated levels of regulatory T cells (Tregs ) have been reported, the extent to which they play a role in sarcoidosis pathogenesis remains unclear. Tumour necrosis factor (TNF) is thought to be one of ... read more the driving forces behind granuloma formation, illustrated by the efficacy of infliximab in severe sarcoidosis. Tregs express TNF receptor 2 (TNFR2) highly. Here, we examined the influence of infliximab therapy on Tregs and (soluble) TNFR2 levels in sarcoidosis, and correlated these with response to therapy. We observed that relative frequencies of Tregs were significantly higher in patients (n = 54) compared to healthy controls (n = 26; median 6·73 versus 4·36%; P , 0·001) and decreased following therapy (4·95; P , 0·001). Baseline TNFR2 expression on Tregs was increased significantly in patients versus controls (99·4 versus 96·2%; P = 0·031), and also in ...
TY - JOUR. T1 - Systemic inflammation in COPD in relation to smoking status. AU - Serapinas, Danielius. AU - Narbekovas, Andrius. AU - Juškevicius, Jonas. AU - Sakalauskas, Raimundas. PY - 2011. Y1 - 2011. N2 - Background and aims: Smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) that has been recently defined as a systemic pulmonary inflammatory disease. However, the impact of smoking itself on systemic inflammation in COPD patients has not yet been well established. The aim of our study was to investigate the association between inflammatory markers and smoking status. Material and methods: We compared 202 current smokers, 61 ex-smokers and 57 never-smokers, all COPD patients. Assessments included medical history, spirometry, alpha-1 antitrypsin (AAT) genotyping, serum AAT, C-reactive protein (CRP), tumor necrosis factor (TNF)- &αλπηα;, and soluble tumor necrosis factor receptor (sTNFR)-1 and sTNFR-2 concentrations. Results: AAT and CRP ...
OPG (osteoprotegerin), a secreted member of the TNF (tumour necrosis factor) receptor superfamily, has a variety of biological functions which include the regulation of bone turnover. OPG is a potent inhibitor of osteoclastic bone resorption and has been investigated as a potential therapeutic for the treatment of both osteoporosis and tumour-induced bone disease. Indeed, in murine models of cancer-induced bone disease, inhibition of osteoclastic activity by OPG was also associated with a reduction in tumour burden. The discovery that OPG can bind to and inhibit the activity of TRAIL (TNF-related apoptosis-inducing ligand) triggered extensive research into the potential role of OPG in the regulation of tumour cell survival. A number of reports from studies using in vitro models have shown that OPG protects tumour cells from the effects of TRAIL, thereby possibly providing tumour cells that produce OPG with a survival advantage. However, the ability of OPG to act as a tumour cell survival factor remains
TWEAK [TNF (tumour necrosis factor)-like weak inducer of apoptosis] is a member of the TNF superfamily of cytokines. TWEAK binds with high affinity to a single TNF receptor super-family member, Fn14 (fibroblast growth factor-inducible 14). This interaction can stimulate a variety of biological responses, depending on the cell type analysed. The murine Fn14 extracellular region is only 53 amino acids in length and primarily consists of a CRD (cysteine-rich domain) containing three disulphide bonds. In the present study, we investigated whether TWEAK binding to this CRD was dependent on selected evolutionarily conserved amino acid residues by using a site-specific mutagenesis approach and several different ligand-binding assays. Our results indicate that three residues within the predicted Fn14 CRD A1 module (Asp45, Lys48 and Met50) and one residue within the predicted D2 module (Asp62) are each critical for high-affinity TWEAK binding. Mutation of the three charged polar residues Asp45, Lys48 and ...
Despite the critical role of TNF-α in the eradication of bacteria, excessively high levels of this cytokine may lead to tissue damage, organ failure, and death, a frequent scenario for septic patients (36). For this reason, TNF-α has been neutralized in many clinical trials in an attempt to prevent the undesirable effects of this cytokine (37). The different approaches considered have included the use of monoclonal antibodies to TNF-α (38) and the TNF receptor fused to the Fc portion of IgG (39). The outcomes of these trials, however, failed to show any significant beneficial effect on the evolution of septic patients, indicating not only that other mediators of inflammation are involved in sepsis but also that, clearly, certain levels of TNF-α are required for bacterial eradication (10, 40). TNF-α supports host antibacterial defenses through several mechanisms, including potentiation of the killing of bacteria by neutrophils and upregulation of vascular and adhesion molecules, which are ...
Human epidermal growth factor receptor (HER)-2 overexpression occurs in 15-20% of all breast cancers and is associated with increased metastatic potential and poor patient survival. Abnormal HER2 activation, either through HER2 overexpression or heregulin (HRG):HER3 binding, elicits the formation of potent HER2-HER3 heterodimers and drives breast cancer cell growth and metastasis. In a previous study, we found that fibroblast growth factor-inducible 14 (Fn14), a member of the TNF receptor superfamily, was frequently overexpressed in human HER2+ breast tumors. We report here that HER2 and Fn14 are also co-expressed in mammary tumors that develop in two different transgenic mouse models of breast cancer. In consideration of these findings, we investigated whether HER2 activation in breast cancer cells could directly induce Fn14 gene expression. We found that transient or stable transfection of MCF7 cells with a HER2 expression plasmid increased Fn14 protein levels. Also, HRG1-β1 treatment of MCF7 ...
Fundamento y objetivo. Evaluar el efecto de los tratamientos anti-TNF sobre la densidad mineral ósea (DMO), los marcadores de remodelado óseo (MRO) y la ratio receptor activator for nuclear factor κB ligand (RANKL, «ligando del receptor activador del factor nuclear κB»)/osteoprotegerina (OPG) en los pacientes con enfermedades inflamatorias articulares crónicas.. Métodos. Estudio longitudinal prospectivo en condiciones de práctica clínica sobre 31 pacientes diagnosticados de artritis reumatoide, artropatía psoriásica y espondilitis anquilosante que estuvieron durante un año en tratamiento con fármacos anti-TNF alfa. Al inicio y al final del estudio se evaluaron la DMO, la OPG y la forma soluble de RANKL (sRANKL), y durante el estudio (0, 3, 6, 9 y 12 meses), la actividad de la enfermedad (SDAI, BASDAI y PCR), la capacidad funcional (HAQ, BASFI), los MRO y la vitamina D.. Resultados. La DMO no se modificó después de un año de tratamiento. Los pacientes que consumieron corticoides ...
In this open extension study, etanercept in a dosage of 25 mg twice daily subcutaneously, twice weekly showed significant clinical efficacy in patients with active AS over 2 years of continuous treatment, confirming earlier short-term (9) and long-term results (13). The clinical results were accompanied by significant improvement of active spinal lesions as assessed by STIR and T1/Gd-DTPA MRI. This finding is consistent with those of a previous study on the same patients after only 24 weeks of etanercept treatment (14).. The efficacy was consistent because all measures of activity, function, and mobility assessed in this study remained low over 2 years, with similar values as seen after 6 and 54 weeks of treatment. Taken together, the data presented here confirm the persistent antiinflammatory effect of etanercept in patients with AS.. There was no indication of a loss of efficacy over 2 years of continuous therapy. Correspondingly, there were only a few flares: 2 of 5 patients who dropped out ...
The tumor necrosis factor (TNF) superfamily includes 29 receptors in humans that interact with a variety of ligands. These receptors fall into 3 major groups, depending on their cytoplasmic domains: death domain containing, TRAF (TNF receptor associated factor)-interacting motif containing, and decoy receptors that have neither of these motifs. The death domain containing receptors initiate cell death programs such as apoptosis and necrosis. The TNF receptors with TRAF-interacting motifs bind with one of the 6 TRAF adaptor proteins to propagate signal transduction. These receptors are involved in inflammatory and immune responses. The final TNF receptor family, the decoy receptors, has no known function but is capable of binding TNF ligands. TNF receptor signaling dysfunction contributes to diseases such as chronic inflammation, Crohns disease, and rheumatoid arthritis. Analyzing the expression, regulation, and sequence of TNF signaling genes can help determine their relative importance to ...
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Fas, a member of the tumor necrosis factor receptor family, can induce apoptosis when activated by Fas ligand binding or anti-Fas antibody crosslinking. Genetic studies have shown that a defect in Fas-mediated apoptosis resulted in abnormal development and function of the immune system in mice. A point mutation in the cytoplasmic domain of Fas (a single base change from T to A at base 786), replacing isoleucine with asparagine, abolishes the signal transducing property of Fas. Mice homozygous for this mutant allele (lprcg/lprcg mice) develop lymphadenopathy and a lupus-like autoimmune disease. Little is known about the mechanism of signal transduction in Fas-mediated apoptosis. In this study, we used the two-hybrid screen in yeast to isolate a Fas-associated protein factor, FAF1, which specifically interacts with the cytoplasmic domain of wild-type Fas but not the lprcg-mutated Fas protein. This interaction occurs not only in yeast but also in mammalian cells. When transiently expressed in L ...
OPG antibody (Biotin) (tumor necrosis factor receptor superfamily, member 11b) for ELISA, WB. Anti-OPG pAb (GTX18068) is tested in Human samples. 100% Ab-Assurance.
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NGF was the first neurotrophin to be discovered, more than 50 years ago. Three other proteins have been added to the list: BDNF, NT-3 and NT-4 (NT-4/5). These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kinase (TrK) receptors are receptor tyrosine kinases (RTKs) and three receptors form this family: TrkA, TrkB, and TrkC.. ...
Amgen and Wyeth Pharmaceuticals, a division of Wyeth, market ENBREL in North America. Wyeth markets ENBREL outside of North America. Immunex Corporation, a wholly owned subsidiary of Amgen, manufactures ENBREL. Additional information about ENBREL, including full Prescribing Information, can be found on the Web site sponsored by the companies at www.enbrel.com or by calling toll free 888-4ENBREL (888-436-2735).. Amgen is a global biotechnology company that discovers, develops, manufactures and markets important human therapeutics based on advances in cellular and molecular biology.. Wyeth Pharmaceuticals, a division of Wyeth, has leading products in the areas of womens health care, cardiovascular disease, central nervous system, inflammation, hemophilia, oncology and vaccines. Wyeth is one of the worlds largest research-driven pharmaceutical and health care products companies. It is a leader in the discovery, development, manufacturing, and marketing of pharmaceuticals, vaccines, biotechnology ...
Signaling by the ubiquitously expressed tumor necrosis factor receptor 1 (TNFR1) after ligand binding plays an essential role in determining whether cells exhibit survival or death. TNFR1 forms distinct signaling complexes that initiate gene expression programs downstream of the transcriptional regulators NFκB and AP-1 and promote different functional outcomes, such as inflammation, apoptosis, and necroptosis. Here, we investigated the ways in which TNFR1 was organized at the plasma membrane at the nanoscale level to elicit different signaling outcomes. We confirmed that TNFR1 forms preassembled clusters at the plasma membrane of adherent cells in the absence of ligand. After trimeric TNFα binding, TNFR1 clusters underwent a conformational change, which promoted lateral mobility, their association with the kinase MEKK1, and activation of the JNK/p38/NFκB pathway. These phenotypes required a minimum of two TNFR1-TNFα contact sites; fewer binding sites resulted in activation of NFκB but not ...
Porcine tumor necrosis factor Alpha,TNFA ELISA Kit is for the quantitative detection of Porcine tumor necrosis factor Alpha,TNFA concentration in serum, plasma and other biological fluids.
Cloning of genomic DNA for tumor necrosis factor and efficient expression in CHO cells.: A genomic clone for human tumor necrosis factor (TNF-alpha) was isolate
Death receptor 6 (DR6, TNFRSF21) is a member of the death receptor family, which belongs to the superfamily of tumor necrosis factor receptors.
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Complete information for TNFRSF1B gene (Protein Coding), TNF Receptor Superfamily Member 1B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Mouse Monoclonal FAS antibody for Func, FACS, ELISA, WB. Published in 2 Pubmed References. Order this anti-FAS antibody. | Product number ABIN967518
Naismith, J. H.; Sprang, S. R. (1995). "Tumor necrosis factor receptor superfamily". Journal of Inflammation. 47 (1-2): 1-7. ...
"The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor- ... "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor ... Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482-91. doi: ...
"The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor ... Bai S, Zha J, Zhao H, Ross FP, Teitelbaum SL (November 2008). "Tumor necrosis factor receptor-associated factor 6 is an ... Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482-91. doi: ... Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J ...
1998). "Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development". Mech. Dev. 71 ... Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H (2003). "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new ... 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 ( ... Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482-91. doi: ...
tumor necrosis factor-activated receptor activity. Компонент клетки. • extracellular region. • integral component of plasma ... Lahey T.P., Loisel S.D., Wieland-Alter W. Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein ... TNFRSF18 (англ. tumor necrosis factor receptor superfamily, member 18) - мембранный белок, рецептор из надсемейства рецепторов ... Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR (англ.) // ...
"Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17". Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L ... This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL- ... Shu HB, Johnson H (August 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". ... Shu HB, Johnson H (August 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". ...
transmembrane signaling receptor activity. • tumor necrosis factor-activated receptor activity. • nerve growth factor binding. ... CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. ... TNFRSF8, CD30, D1S166E, Ki-1, tumor necrosis factor receptor superfamily member 8, TNF receptor superfamily member 8. ... "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ...
CS1 maint: discouraged parameter (link) Zeggini, E. (2002). "Tumour necrosis factor receptor II polymorphism and juvenile ...
"A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis". Proc ... Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) ... TNFRSF18 is a member of the tumor necrosis factor receptor (TNF-R) superfamily. This receptor has been shown to have increased ... glucocorticoid-induced tumor necrosis factor receptor) is a surface receptor molecule that has been shown to be involved in ...
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is ... "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A". Campbell S, Michaelson J, Burkly L, Putterman C ... 2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling ... 2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and ...
Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene. The protein encoded by ... "Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19". Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA ... 2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and ... Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma ...
It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. It is the sole known ligand for death receptor ... "Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15". Wang EC (Sep 2012). "On death receptor 3 and its ... This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is ...
"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS ... "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS ... "Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B". Wu Y, Bressette D, Carrell JA, Kaufman T, Feng ... TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered ...
This cleaving process is called "receptor ectodomain shedding. In humans and rabbits, tumor-necrosis factor alpha converting ... the tumour necrosis factor-alpha-converting enzyme (TACE)". The Biochemical Journal. 377 (Pt 2): 379-84. doi:10.1042/BJ20031321 ... "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells". Nature. 385 (6618): 729-33. doi:10.1038 ... "A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and ...
Similarly to etanercept, pegsunercept is a soluble tumor necrosis factor receptor. Pegsunercept is a PEGylated protein. ... "A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with ...
Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene. C1QTNF1 has ... Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting ... "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1". Innamorati G, Whang MI, Molteni R, Le Gouill C, ... "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue". FEBS Letters. 580 (16): 3953- ...
... is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co- ... May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein ... a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long ...
Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene. The protein ... Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily ... "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like". v t e. ... "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human". J Biol Chem. 281 (20): ...
... beta receptor Tumor necrosis factor-alpha#Discovery Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, ... Schlüter D, Deckert M (August 2000). "The divergent role of tumor necrosis factor receptors in infectious diseases". Microbes ... Schlüter D, Deckert M (August 2000). "The divergent role of tumor necrosis factor receptors in infectious diseases". Microbes ... Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for ...
tumor necrosis factor receptor superfamily binding. • tumor necrosis factor receptor binding. • receptor binding. • zinc ion ... Receptor/signaling modulators. Signaling peptide/protein receptor modulators. Growth factor receptor modulators. ... TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, ... TRAIL shows homology to other members of the tumor necrosis factor superfamily. It is composed of 281 amino acids and has ...
Tomsig JL, Sohma H, Creutz CE (2004). "Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by ...
... is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor ... "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor- ... "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor- ... a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family". Gene. 134 (2): 295-8. doi:10.1016/0378- ...
The Tumor Necrosis Factor Receptor can signal for both apoptosis and necroptosis. The RIPK1 protein can also signal for both ... TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which ... Toll-like receptors (TLRs) can also signal to the necrosome, leading to necroptosis. TLRs are a class of receptors that ... First, extrinsic stimulus through the TNF receptor by TNFα signals the recruitment of the TNF receptor-associated death domain ...
Evidence for immunological cross reactivity with cell surface tumor-necrosis-factor receptors. J. Biol. Chem. 265, 1531-1536. ... PMID 3889916 Engelmann, H., Novick, D. and Wallach, D. (1990): Two tumor necrosis factor binding proteins purified from human ... Tumor Necrosis Factor) family', as well as on cell-death mechanisms. Wallach's lab was of the first to demonstrate that TNF can ... Wallach was among the first to isolate TNF and its receptors. He deciphered the extrinsic cell-death pathway, as well as some ...
Tvb is a member of the tumor necrosis factor receptor (TNFR) family. The Tvc receptor is closely related to mammalian ... Tva contains sequences related to the ligand binding region of low-density lipoprotein receptors (LDLR). The Tvb receptor is ... Elleder D, Plachý J, Hejnar J, Geryk J, Svoboda J (2004). "Close linkage of genes encoding receptors for subgroups A and C of ... Viral glycoprotein-receptor interactions are required to initiate membrane fusion of the virus and cell. The surface ...
IRE-1α also recruits tumor necrosis factor receptor-associated factor 2 (TRAF2). This kinase cascade that is dependent on IRE-1 ... ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... is upregulated downstream of the bZIP transcription factor ATF4 (activating transcription factor 4) and uniquely responsive to ... These receptor proteins have been identified as: Inositol-requiring kinase 1, whose free luminal domain activates itself by ...
"A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological ... "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological ... Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers. GRCh38: Ensembl ...
"A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological ... HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. ... Stabilization by USP7 is important for the tumor suppressor function of p53. In cells, EBNA1 can sequester USP7 from p53 and ... The fact that viral proteins have evolved so as to target USP7, underscores the significance of USP7 in tumor suppression and ...
... a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and ... a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and ... also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF- ... Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (May 1999). "A newly identified member of tumor necrosis factor receptor ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... C. acnes' ability to bind and activate a class of immune system receptors known as toll-like receptors (TLRs), especially TLR2 ... Flutamide, a pure antagonist of the androgen receptor, is effective in treating acne in women.[112][120] It appears to reduce ... High levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are also associated with worsened acne.[42] Both ...
... and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine ... ReceptorEdit. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).[8] It belongs to the ... The SP receptor promoter contains regions that are sensitive to cAMP, AP-1, AP-4, CEBPB,[13] and epidermal growth factor. ... "Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout ...
"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS ... "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proc. Natl. Acad. Sci. U.S.A. 97 ( ... "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.". Proc. Natl. Acad. Sci. U.S.A. 97 ... "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". J. Exp. ...
Most important of which is the TNF (tumor necrosis factors) with 3 loci in the region. Starting from B8, immediately followed ... Later the level of anti-acetylcholine receptor antibodies in disease were found to correlate with B8::DR3.[15] Later it was ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ... 1993). "Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes". ...
"Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment ... Necrosis Coagulative necrosis. Liquefactive necrosis. Gangrenous necrosis. Caseous necrosis. Fat necrosis. Fibrinoid necrosis. ... Cells, circulating tumor cells (CTCs), or formalin-fixed paraffin-embedded (FFPE) or frozen tissue sections are fixed, then ... Fluorescent signal strength depends on many factors such as probe labeling efficiency, the type of probe, and the type of dye. ...
... activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. UNITED ... 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during ... activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5): ... 1997). "Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor". Cancer Res. 57 (19): 4177-82. PMID ...
... tumor necrosis factor (TNF) ... radiology - randomized trial - rebound - receptor (immunology) ... granulocyte macrophage-colony stimulating factor (GM-CSF) - granulocyte-colony stimulating factor (G-CSF) - granulocytopenia ... host factors - HPTN - HPV - HRSA - HTLV-I - HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - HTLV-II - ... co-receptors - coccidioidomycosis - codon - cofactors - cognitive impairment - cohort - colitis - combination therapy - ...
... causing tumor recurrence. For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF ... apoptosis has been shown to enhance apoptosis caused by chemotherapeutic drugs through autocrine-secreted tumor necrosis factor ... and FGF receptors in NSCLC cell lines, and found that FGF2, FGF9 and their receptors encompass a growth factor autocrine loop ... One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. ...
"Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an ... Interleukin 8 receptor, beta. Reference[uredi - уреди , uredi izvor]. *↑ Wolff B, Burns AR, Middleton J, Rot A (November 1998 ... 2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 ... 2000). "Permissive factors for HIV-1 infection of macrophages". J. Leukoc. Biol. 68 (3): 303-10. PMID 10985244. CS1 održavanje ...
There is evidence that emphasizes the role of autophagy both as a tumor suppressor as well as a factor in tumor cell survival. ... including endocytosis and endocytic degradation of activated growth factor receptors. In support of the possibility that ... Necrosis and chronic inflammation also has been shown to be limited through autophagy which helps protect against the formation ... Tumor cell survival[edit]. Alternatively, autophagy has also been shown to play a huge role in tumor cell survival. In ...
tumor necrosis factor receptor binding. • cytokine activity. • identical protein binding. Cellular component. • membrane. • ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF).[14] Both factors were ...
Neurons of PD patients show hypomethylation of tumor necrosis factor (TNF) alpha encoding sequence, overexpression of which ... dopamine 2 receptor, and Penk1 - preproenkephalin).[84] For both late- and early-onset Huntington's, the H3 and H4 core ... a neurotrophic factor important for long-term memory.[66] Expression of CREB, an activity-dependent transcription factor ... Several genetic factors have been identified as contributing to AD, including mutations to the amyloid precursor protein (APP) ...
... such as interferon or tumor necrosis factor) produced from influenza-infected cells.[24][97] In contrast to the rhinovirus that ... In contrast, the highly lethal H5N1 strain binds to receptors that are mostly found deep in the lungs.[94] This difference in ... Increased travel due to the Northern Hemisphere winter holiday season may also play a role.[163] Another factor is that cold ... Kark JD, Lebiush M, Rannon L (October 1982). "Cigarette smoking as a risk factor for epidemic a(h1n1) influenza in young men". ...
Thalidomide was discovered to inhibit tumour necrosis factor-alpha (TNF-α) in 1991. TNF-α is a cytokine produced by macrophages ... and its receptor, bFGF and IL-6 appear to be required for endothelial cell migration during angiogenesis. Thalidomide and its ... a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor". Journal of Medicinal Chemistry. 52 (6): ... "Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity". Journal of ...
"Tumor necrosis factor-alpha is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits". Department of ... "The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced ... "Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic ... Tumor juga ditemukan di permukaan non-valvular, seperti di bilik kiri. Ukuran tumor bervariasi dari 2 mm hingga 70 mm.[46] ...
"Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of ... "Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and ... increased levels of P-selectin mRNA and protein are induced by inflammatory mediators such as tumor necrosis factor-a (TNF-a), ... Its activity in tumor metastasis has been probed by the addition of heparin that functions to blocks tumor metastasis. In ...
... a monoclonal antibody to tumor necrosis factor α: Findings in open-label and randomized placebo-controlled trials". Arthritis ... "Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective ... Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF)[1] are autoantibodies that bind to contents of the cell ... The La antigen is a 48kDa transcription termination factor of RNA polymerase III, which associates with the Ro-RNP complex.[15] ...
In vitro data also suggest that activated protein C may exert an anti-inflammatory effect by inhibiting tumor necrosis factor ... ADP receptor/P2Y12 inhibitors. *Thienopyridines *Clopidogrel. *Prasugrel. *Ticlopidine. *Nucleotide/nucleoside analogs * ... Factor Xa inhibitors. (with some II inhibition). Heparin group/. glycosaminoglycans/. (bind antithrombin). *Low molecular ... In vitro data suggest that activated protein C exerts an antithrombotic effect by inhibiting factors Va and VIIIa, and that it ...
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture). See also. Receptor/signaling modulators. ... Tumor necrosis factor. *Wnt protein. see also extracellular ligand disorders. *v. *t ... transmembrane-ephrin receptor activity. • protein binding. • ephrin receptor binding. Cellular component. • anchored component ... The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been ...
Tumor necrosis factor alpha. Receptor. *Tumor necrosis factor receptor 1. *Tumor necrosis factor receptor 2 ... The release of small amounts of cyt c leads to an interaction with the IP3 receptor (IP3R) on the endoplasmic reticulum (ER), ... Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor-1 (Apaf-1).[5] ... Kroemer G, Dallaporta B, Resche-Rigon M (1998). "The mitochondrial death/life regulator in apoptosis and necrosis". Annual ...
AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such as tumor necrosis factor ( ... Steward, Oswald (2001). "Selective targeting of newly-synthesized Arc mRNA to active synapses requires NMDA receptor activation ... Messages that are being actively translated are bound by ribosomes, the eukaryotic initiation factors eIF-4E and eIF-4G, and ... AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos.[29] ...
In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) secreted by tumor cells or by an ... pancreatic tumors (leading to adipose nodular necrosis of subcutaneous tissues, flushes (prostaglandin secretions), and even ... January 2007). "Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma". Ann. Neurol. ... In this paradigm, tumor cells express tissue-restricted antigens (e.g., neuronal proteins), triggering an anti-tumor immune ...
... transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha ... tumor necrosis factor α (TNF-α), tumor necrosis factor β (TNF-β), transforming growth factor α (TGF-α),[67] transforming growth ... "Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial ... factor β (TGF-β),[68] heregulin,[69] Wnt,[40] RANKL,[40] and leukemia inhibitory factor (LIF).[40] These factors regulate ...
... tumor necrosis factor,[22] chemokines,[23] and others. Colostrum also contains a number of growth factors, such as insulin-like ... "Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine". Am. J. Clin. Nutr. ... Rudloff HE, Schmalstieg FC, Mushtaha AA, Palkowetz KH, Liu SK, Goldman AS (January 1992). "Tumor necrosis factor-alpha in human ... transforming growth factors alpha,[26] beta 1 and beta 2,[27][28] fibroblast growth factors,[29] epidermal growth factor,[30] ...
Tumor hypoxia, the situation where tumor cells have been deprived of oxygen ... 2, but below normal the activity of neurons innervating these receptors increases dramatically, so much so to override the ... Chronic alveolar hypoxia is the main factor leading to development of cor pulmonale-right ventricular hypertrophy with or ... Fink effect, or diffusion hypoxia, a factor that influences the partial pressure of oxygen within the pulmonary alveolus ...
"Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature 316 (6028): 552-4. Bibcode:1985Natur. ... O TNFα pode unirse a dous receptores, o TNFR1 (receptor de TNF tipo 1; CD120a; p55/60) e o TNFR2 (receptor de TNF de tipo 2; ... Old LJ (1985). "Tumor necrosis factor (TNF)". Science 230 (4726): 630-2. Bibcode:1985Sci...230..630O. PMID 2413547. doi:10.1126 ... Tumor Necrosis Factor-alpha Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA. ...
Cytokines such as tumor necrosis factor, interleukin 1, and interleukin 6 may activate procoagulation factors in the cells ... the toll-like receptors, the C-type lectin receptors, the NOD-like receptors, and the RIG-I-like receptors. Invariably, the ... Microbial factors[edit]. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune ... Consequentially, transcription factors such as nuclear factor-kappa B and activator protein-1, will up-regulate the expression ...
Correlation with its inhibitory effect on tumor necrosis factor-alpha production". J. Biol. Chem. 272 (25): 15920-7. PMID ... que poden activar excesivamente as células T ao unirse ao receptor de células T. Como YpM pode activar grandes cantidades de ... "Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection". Infect. Immun. 66 ... Estruturalmente, é diferente a calquera outro superantíxeno, mais é moi similar ao factor de necrose tumoral e a proteínas de ...
The inflammatory mediators are: Interleukin 1 beta, Interleukin 6, Tumor necrosis factor alpha (TNF alpha), MMP1, MMP2, MMP9, ... endothelin receptor A and cyclin dependent kinase inhibitor. Mutations in interleukin 6 may be protective.[citation needed]. ... Risk factors[edit]. Intracranial aneurysms may result from diseases acquired during life, or from genetic conditions. Lifestyle ... The most significant factors in determining outcome are the Hunt and Hess grade, and age. Generally patients with Hunt and Hess ...
Tumor necrosis factor receptor-associated periodic syndrome (commonly known as TRAPS) is a condition characterized by recurrent ... Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated ... medlineplus.gov/genetics/condition/tumor-necrosis-factor-receptor-associated-periodic-syndrome/ Tumor necrosis factor receptor- ... Tumor necrosis factor receptor-associated periodic syndrome (commonly known as TRAPS) is a condition characterized by recurrent ...
Tumor necrosis factor receptor 27, N-terminal (IPR034060). Short name: TNFRSF27_N ... Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.. ... TNFRSF27 (also known as ectodysplasin-A2 receptor (EDA2R), X-linked ectodermal dysplasia receptor (XEDAR), EDAA2R, EDA-A2R) is ... TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand- ...
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. A Ashkenazi, S A Marsters, D J Capon, S M ... Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. A Ashkenazi, S A Marsters, D J Capon, S M ... Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. A Ashkenazi, S A Marsters, D J Capon, S M ... Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin Message Subject (Your Name) has sent you a ...
Cytokines and Growth Factors > Tumor Necrosis Factor (TNF) Superfamily > TNF Receptors ... Anti-Tumor Necrosis Factor Soluble Receptor Type II antibody produced in goat IgG fraction of antiserum, lyophilized powder * ... Anti-Tumor Necrosis Factor Soluble Receptor I antibody produced in goat affinity isolated antibody, lyophilized powder * ... Anti-Tumor Necrosis Factor Soluble Receptor II antibody produced in goat affinity isolated antibody, lyophilized powder * ...
Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ... tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B ... is a membrane receptor that binds tumor necrosis factor-alpha (TNFα). The protein encoded by this gene is a member of the tumor ... a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and ...
Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ... a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". ...
... on WN Network delivers the latest Videos and Editable pages for News & Events, including ... Tumor necrosis factor receptor 2. Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor ... Tumor necrosis factor receptor 1. Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor ... Tumor necrosis factor alpha. Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell ...
Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo.. Speiser DE1, Sebzda E, ... Receptors, Tumor Necrosis Factor/physiology*. *Receptors, Tumor Necrosis Factor, Type I. *T-Lymphocytes, Cytotoxic/immunology* ... marked expansion and prolonged persistence of functional activated cytotoxic T cells in mice lacking the tumor necrosis factor ... TNF) receptor p55. In the absence of this receptor, peripheral lymphocyte apoptosis was significantly reduced in vivo. The ...
... ... "Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy," BioMed ...
H2 2019SummaryTumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX T ... ... Tumor Necrosis Factor Receptor Superfamily Member 4 - Pipeline Review, ... Tumor Necrosis Factor Receptor Superfamily Member 4 - Pipeline Review, H2 2019. Summary. Tumor Necrosis Factor Receptor ... Tumor Necrosis Factor Receptor Superfamily Member 4 or OX40 is a member of the TNF-receptor superfamily. This receptor has been ...
IPR020445 Tumour necrosis factor receptor 4. IPR034022 Tumour necrosis factor receptor 4, N-terminal ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
IPR020413 Tumour necrosis factor receptor 9. IPR034020 Tumour necrosis factor receptor 9, N-terminal ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
Abstract 707: Tumor Necrosis Factor-alpha p75 Receptor, Sattelite-Cell Activation and Neovascularization. David A Goukassian, ... Abstract 707: Tumor Necrosis Factor-alpha p75 Receptor, Sattelite-Cell Activation and Neovascularization ... Abstract 707: Tumor Necrosis Factor-alpha p75 Receptor, Sattelite-Cell Activation and Neovascularization ... Abstract 707: Tumor Necrosis Factor-alpha p75 Receptor, Sattelite-Cell Activation and Neovascularization ...
Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A ... in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis ... Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling ... Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus ...
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. Aizawa, ... Signal transduction in anaplastic large cell lymphoma cells (ALCL) mediated by the tumor necrosis factor receptor CD30. ... CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated ... CD30 is a member of the tumor necrosis factor receptor (TNFR) superfamily expressed on activated T and B lymphocytes and ...
receptors, tumour necrosis factor cell surface receptors that bind tumour necrosis factor and trigger changes which influence ... The two recognised tumour necrosis factor receptors are designated alpha and beta receptors. Both receptors bind both alpha and ... beta tumour necrosis factors with high affinity, and both are members of the nerve growth factor receptor family. ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Receptors_tumour_necrosis_factor&oldid=66029" ...
Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved ... Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the ... Tumor necrosis factor receptor superfamily member 21Add BLAST. 614. Amino acid modifications. Feature key. Position(s). ... sp,O75509,TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 OS=Homo sapiens OX=9606 GN=TNFRSF21 PE=1 SV=1 ...
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) ... Tumor necrosis factor receptor superfamily member 6Add BLAST. 316. Amino acid modifications. Feature key. Position(s). ... sp,O77736,TNR6_PIG Tumor necrosis factor receptor superfamily member 6 OS=Sus scrofa OX=9823 GN=FAS PE=2 SV=1 ... Tumor necrosis factor receptor superfamily member 6. CERAT. 331. UniRef50_Q9BDN4. Tumor necrosis factor receptor superfamily ...
... chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin ... Tumor necrosis factor-α treatment significantly enhanced (P , .05) the mRNA levels of chemerin in human visceral adipocytes, ... levels in obesity and the effect of weight loss and to analyze the effect of the stimulation with tumor necrosis factor-α in ... Our aim was to determine the effect of chemerin and its receptor, chemokine-like receptor-1, in obesity-associated low-grade ...
tumor necrosis factor;. TCR,. T cell receptor;. NFAT,. nuclear factor of activated T cells;. CAT,. chloramphenicol ... A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression. ... A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression ... A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression ...
Therapeutic Strategy in NASH With a Unique Tumor Necrosis Factor Receptor 1 (TNF-R1) Antibody Drug Candidate Transaction ... tumor necrosis factor receptor 1 (TNF-R1). Combining this novel therapeutic strategy with Prometheras unique liver cell-based ... With the TNF-alpha pathway and its Receptor 1 (R1) being implicated in the progression of many inflammatory diseases, including ...
Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs ... K. Pfeffer, "Biological functions of tumor necrosis factor cytokines and their receptors," Cytokine and Growth Factor Reviews, ... Induction of Tumor Necrosis Factor (TNF) Release from Subtypes of T Cells by Agonists of Proteinase Activated Receptors. ... P. S. Thomas, "Tumour necrosis factor-α: the role of this multifunctional cytokine in asthma," Immunology and Cell Biology, vol ...
Abstract 305: Tumor Necrosis Factor-α p75 Receptor, Satellite-Cell Survival, Activation and Muscle Regeneration. David A ... Abstract 305: Tumor Necrosis Factor-α p75 Receptor, Satellite-Cell Survival, Activation and Muscle Regeneration ... Abstract 305: Tumor Necrosis Factor-α p75 Receptor, Satellite-Cell Survival, Activation and Muscle Regeneration ... Abstract 305: Tumor Necrosis Factor-α p75 Receptor, Satellite-Cell Survival, Activation and Muscle Regeneration ...
Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin ... Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin ... Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin ... Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin ...
... tumor necrosis factor alpha, TNFα. These receptors have a central role in human pregnancy. Although each receptor induces ... The soluble forms of these receptors can bind to TNFα, neutralizing its effects. In normal human pregnancy, TNFα receptors are ... Advances in anti-TNFα therapy may have potential use in the management of complicated pregnancies.Keywords: TNFα receptors, ... Changes in TNFα and its receptors are associated with adverse pregnancy outcomes, including miscarriage, preterm labor and ...
Tumor necrosis factor receptor 1 (TNFR1) is a membrane receptor able to bind TNF-alpha or TNF-beta. TNFR1 can suppress ... Silencing of tumor necrosis factor receptor 1 by siRNA in EC109 cells affects cell proliferation and apoptosis.. [Ma Changhui, ...
Interferon-γ receptor-mediated but not tumor necrosis factor receptor type 1-or type 2-mediated signaling is crucial for the ... Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic ... Antiviral activity of tumor necrosis factor (TNF) is mediated via p55 and p75 TNF receptors. J Exp Med. 1997;186:1591-6. [ ... Tumor necrosis factor α receptors: role in the physiopathology of protozoan parasite infections. Int J Parasitol. 2001;31:763-9 ...
"Regulation and Dysregulation of Tumor Necrosis Factor Receptor-1." CYTOKINE & GROWTH FACTOR REVIEWS 25.3 (2014): 285-300. Print ... "Regulation and Dysregulation of Tumor Necrosis Factor Receptor-1." Cytokine & Growth Factor Reviews 25 (3): 285-300. ... Regulation and dysregulation of tumor necrosis factor receptor-1. CYTOKINE & GROWTH FACTOR REVIEWS, 25(3), 285-300. ... Regulation and dysregulation of tumor necrosis factor receptor-1. Leen Puimège (UGent) , Claude Libert (UGent) and Filip Van ...
... implication of the p80 tumor necrosis factor receptor.. ... implication of the p80 tumor necrosis factor receptor.. L S Liu ... Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis ... Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis ... Tumor necrosis factor (TNF)-alpha is postulated to play a major role in the pathogenesis of obesity-linked insulin resistance, ...
Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 ... a higher molecular mass complex at least in part because of the recruitment of tumor necrosis factor receptor-associated factor ... TNF Receptor-Associated Factor 2 / metabolism* * TNF Receptor-Associated Factor 6 / metabolism* ...
  • TNFRSF27 (also known as ectodysplasin-A2 receptor (EDA2R), X-linked ectodermal dysplasia receptor (XEDAR), EDAA2R, EDA-A2R) is a member of the TNFR superfamily that is recognised by ectodysplasin-A2 (EDA-A2), which is generated by alternative splicing of the EDA receptor (EDAR) ligand EDA-A1 [ PMID: 11039935 ]. (ebi.ac.uk)
  • Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. (nih.gov)
  • See the reference protein sequence for tumor necrosis factor receptor superfamily member 11B precursor (NP_002537.3). (nih.gov)
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. (nih.gov)
  • The tumor necrosis factor receptor superfamily (TNFRSF) is a group of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine -rich domain. (wn.com)
  • Tumor necrosis factor receptor 2 ( TNFR2 ), also known as tumor necrosis factor receptor superfamily member 1B ( TNFRSF1B ) and CD120b , is a membrane receptor that binds tumor necrosis factor-alpha (TNFα). (wn.com)
  • The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A . (wn.com)
  • Tumor necrosis factor receptor 1 ( TNFR1 ), also known as tumor necrosis factor receptor superfamily member 1A ( TNFRSF1A ) and CD120a , is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα). (wn.com)
  • implicate a type-2 transmembrane protein, 4-1BBL (also called CD137L)--a member of the tumor necrosis factor (TNF) superfamily--in such sustained cytokine production by macrophages. (sciencemag.org)
  • Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Tumor Necrosis Factor Receptor Superfamily Member 4 or OX40 is a member of the TNF-receptor superfamily. (reportlinker.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) pipeline Target constitutes close to 26 molecules. (reportlinker.com)
  • The latest report Tumor Necrosis Factor Receptor Superfamily Member 4 - Pipeline Review, H2 2019, outlays comprehensive information on the Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportlinker.com)
  • It also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics development with respective active and dormant or discontinued projects. (reportlinker.com)
  • Tumor necrosis factor receptor superfamily (TNFRSF) members were initially identified as immunological mediators, and are still commonly perceived as immunological molecules. (degruyter.com)
  • As a ligand, TNF-α binds to two members of TNF-receptor superfamily: TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2). (bmj.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I or p55 or p60 or CD120a or TNFRSF1A) pipeline Target constitutes close to 13 molecules. (reportlinker.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I or p55 or p60 or CD120a or TNFRSF1A) - Tumor necrosis factor receptor 1 (TNFR1) is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFalpha). (reportlinker.com)
  • Furthermore, this report also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 1A (Tumor Necrosis Factor Receptor 1 or Tumor Necrosis Factor Receptor Type I or p55 or p60 or CD120a or TNFRSF1A) targeted therapeutics development with respective active and dormant or discontinued projects. (reportlinker.com)
  • Subsequent identification of the mouse BCMA gene and further motif analysis led to the prediction that BCMA is a member of the TNF receptor superfamily ( 10 ). (rupress.org)
  • Objective- Mouse aorta smooth muscle cells (SMC) express tumor necrosis factor receptor superfamily member 1A (TNFR-1) and lymphotoxin β-receptor (LTβR). (ahajournals.org)
  • Tumor Necrosis Factor Receptor Superfamily Member 9 (4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) - Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137 is a member of the tumor necrosis factor (TNF) receptor family. (researchandmarkets.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 9 (4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) pipeline Target constitutes close to 28 molecules. (researchandmarkets.com)
  • It also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 9 (4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 6 (Apo 1 Antigen or Apoptosis Mediating Surface Antigen FAS or FASLG Receptor or TNFRSF6 or CD95 or FAS) pipeline Target constitutes close to 5 molecules. (researchandmarkets.com)
  • It also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 6 (Apo 1 Antigen or Apoptosis Mediating Surface Antigen FAS or FASLG Receptor or TNFRSF6 or CD95 or FAS) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 18 market is segmented by Type, and by Application. (reportsnreports.com)
  • Players, stakeholders, and other participants in the global Tumor Necrosis Factor Receptor Superfamily Member 18 market will be able to gain the upper hand as they use the report as a powerful resource. (reportsnreports.com)
  • The Tumor Necrosis Factor Receptor Superfamily Member 18 market is analysed and market size information is provided by regions (countries). (reportsnreports.com)
  • The key regions covered in the Tumor Necrosis Factor Receptor Superfamily Member 18 market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. (reportsnreports.com)
  • Tumor Necrosis Factor Receptor Superfamily Member 18 market competitive landscape provides details and data information by players. (reportsnreports.com)
  • Details included are company description, major business, company total revenue and the sales, revenue generated in Tumor Necrosis Factor Receptor Superfamily Member 18 business, the date to enter into the Tumor Necrosis Factor Receptor Superfamily Member 18 market, Tumor Necrosis Factor Receptor Superfamily Member 18 product introduction, recent developments, etc. (reportsnreports.com)
  • Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types. (semanticscholar.org)
  • article{Huggins2004SheddingOM, title={Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types. (semanticscholar.org)
  • OBJECTIVE To investigate the effect of mutations in tumor necrosis factor receptor superfamily 1A (TNFRSF1A) on the ability of the receptors to be cleaved from the cell surface upon stimulation. (semanticscholar.org)
  • Symptoms related to tumor necrosis factor receptor 1-associated periodic syndrome, multiple sclerosis, and severe rheumatoid arthritis in patients carrying the TNF receptor superfamily 1A D12E/p.Asp41Glu mutation. (semanticscholar.org)
  • MBS288817 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • The tumor necrosis factor (TNF) superfamily of cytokines activate signaling pathways for cell survival, death, and differentiation. (sinobiological.com)
  • Members of the tumor necrosis factor superfamily act through ligand-mediated trimerization, causing recruitment of several intracellular adaptors to activate multiple signal transduction pathways. (sinobiological.com)
  • 2004) C1q and tumor necrosis factor superfamily: modularity and versatility. (sinobiological.com)
  • 2009) Immunoregulation by tumor necrosis factor superfamily member LIGHT. (sinobiological.com)
  • This gene provides instructions for making a protein called tumor necrosis factor receptor 1 (TNFR1). (medlineplus.gov)
  • Animal disease models had revealed the antithetic effects of the two TNF receptors (TNFR) in the central nervous system, whereby TNFR1 has been associated with inflammatory degeneration and TNFR2 with neuroprotection. (nih.gov)
  • However, little is known about the role of TNF receptors (TNFR1/p55 and TNFR2/p75) in angiogenic signaling and muscle regeneration. (ahajournals.org)
  • 7-9 TNF- α exerts its main effects by binding to two high-affinity cell surface receptors, TNFR1 (p55) and TNFR2 (p75). (scielo.br)
  • TNF initiates cellular inflammatory responses through engagement with two cell surface receptors: TNF receptor 1 (TNFR1) and TNFR2. (sciencemag.org)
  • S. aureus protein A plays a key role in regulating inflammation through its ability to bind and signal through the TNF-α receptor 1 (TNFR1). (asm.org)
  • TNF-α-induced signaling is modulated by the availability of its cognate receptor, TNF receptor 1 (TNFR1), at the cell surface. (asm.org)
  • TNFR1 is cleaved from the cell surface by ADAM17 ( 15 - 17 ), a mechanism that decreases the amount of receptor available to respond to the ligand and terminates TNF-α signaling, thus modulating inflammation ( 18 , 19 ). (asm.org)
  • Using immunostaining, we demonstrated that TNFα receptors TNFR1 and TNFR2 are expressed on native human tracheal smooth muscle. (aspetjournals.org)
  • These data suggest that TNFR1, through a TNF receptor-associated factor 2-NF-κB signaling pathway, mediates TNFα-induced expression of ICAM-1 on ASM cells by involving a thapsigargin-sensitive signaling pathway. (aspetjournals.org)
  • Etanercept and neutralizing antibodies to tumor necrosis factor receptor 1 (TNFR1) were used to block TNF signaling. (biomedcentral.com)
  • Both TNFR1 neutralizing antibodies and the soluble TNF receptor Etanercept blocked TNF-induced PKCδ proteolytic activation. (biomedcentral.com)
  • Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. (mybiosource.com)
  • The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. (rupress.org)
  • TNFR1 regulates BACE1 promoter activity via the nuclear factor-κB pathway, and the deletion of TNFR1 in APP23 transgenic mice prevents learning and memory deficits. (rupress.org)
  • This assay has high sensitivity and excellent specificity for detection of Tumor Necrosis Factor Receptor 1 (TNFR1). (uscnk.com)
  • No significant cross-reactivity or interference between Tumor Necrosis Factor Receptor 1 (TNFR1) and analogues was observed. (uscnk.com)
  • Matrices listed below were spiked with certain level of recombinant Tumor Necrosis Factor Receptor 1 (TNFR1) and the recovery rates were calculated by comparing the measured value to the expected amount of Tumor Necrosis Factor Receptor 1 (TNFR1) in samples. (uscnk.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Tumor Necrosis Factor Receptor 1 (TNFR1) were tested 20 times on one plate, respectively. (uscnk.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Tumor Necrosis Factor Receptor 1 (TNFR1) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
  • The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Tumor Necrosis Factor Receptor 1 (TNFR1) and their serial dilutions. (uscnk.com)
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Tumor Necrosis Factor Receptor 1 (TNFR1). (uscnk.com)
  • Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Tumor Necrosis Factor Receptor 1 (TNFR1). (uscnk.com)
  • After TMB substrate solution is added, only those wells that contain Tumor Necrosis Factor Receptor 1 (TNFR1), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (uscnk.com)
  • Tumor necrosis factor ( TNF , tumor necrosis factor alpha , TNFα , cachexin , or cachectin ) is a cell signaling protein ( cytokine ) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction . (wn.com)
  • The 4-1BBL acts as a ligand for the receptor 4-1BB in T cells, but 4-1BB appeared not to be required for the promotion of cytokine production by 4-1BBL because macrophages lacking 4-1BB produced normal amounts of TNF after stimulation with LPS. (sciencemag.org)
  • OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. (reportlinker.com)
  • This compound did not bind detectably to the related cytokine receptors TNFRc2 or CD40, and did not display any cytotoxicity at concentrations as high as 100 microM. (rcsb.org)
  • Cytokine Growth Factor Rev. 13 (4-5): 315-21. (wikipedia.org)
  • TNFα receptors, TNF-R1 and TNF-R2, mediate the biological activities of the multifunctional cytokine, tumor necrosis factor alpha, TNFα. (edu.mt)
  • Tumor necrosis factor alpha (TNF-alpha), a cytokine, is widely known to activate nuclear factor-kappa B (NF-kappaB) transcription in beta cells. (nih.gov)
  • This study aimed to investigate the serum levels of the cytokine TNF- α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. (scielo.br)
  • Cytokine & Growth Factor Reviews 25 (3): 285-300. (ugent.be)
  • Tumor necrosis factor (TNF), a proinflammatory cytokine secreted mostly by immune cells, plays an important role in the pathophysiology of sepsis. (sciencemag.org)
  • Our aim was to investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on plaque stability involving matrix metalloproteinases (MMPs) and examine the effect of inflammatory cytokine TNF-α in symptomatic (S) compared to asymptomatic (AS) patients with carotid stenosis. (ahajournals.org)
  • For neuroinflammation and the increase in cytokine levels (either by glia or neurons) to influence neurons and consequently affect the development of CNS disorders, the location of these cytokines receptors on neuronal populations may be the key. (omicsonline.org)
  • Tumor necrosis factor alpha (TNF) is a key cytokine in the defense against many intracellular pathogens, including Rickettsia conorii, the causative agent of Mediterranean spotted fever (MSF). (asm.org)
  • Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed elevated levels of tumor necrosis factor (TNF) receptor-1 which were associated with poor clinical outcome. (haematologica.org)
  • The critical role of tumor necrosis factor alpha (TNF-α) in the initial host defense against systemic staphylococcal infection has been demonstrated in experimental models and may partially explain the lack of significant benefits observed in clinical trials attempting to neutralize this cytokine in septic patients. (asm.org)
  • TR6 was found to inhibit the interaction of TL1A, a T-cell costimulatory cytokine, with its receptor DR3 ( 18 ). (asm.org)
  • This study characterizes the receptor involved as well as critical downstream signaling events mediating cytokine-induced NF-κB activation and ICAM-1 expression. (aspetjournals.org)
  • Tumour necrosis factor-α (TNF-α) is a pleiotropic pro-inflammatory cytokine, which is rapidly upregulated in the brain after injury. (biomedcentral.com)
  • Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures. (ox.ac.uk)
  • OBJECTIVE: To determine whether selective blockade of tumor necrosis factor receptor I (TNFRI) affects spontaneous proinflammatory cytokine and chemokine production in ex vivo-cultured human rheumatoid arthritis synovial membrane mononuclear cells (MNCs) and to compare this response to that of TNF ligand blockade using etanercept. (ox.ac.uk)
  • The first two members of the family to be identified were: Tumor Necrosis Factor Alpha (TNF Alpha) and Tumor necrosis factor-beta (TNF-β), also known as Lymphotoxin-alpha, a cytokine that is inhibited by interleukin 10. (sinobiological.com)
  • Cytokine Growth Factor Rev. 14(3-4):193-209. (sinobiological.com)
  • Four members of the tumor necrosis factor (TNF) ligand family, TNF-alpha, LT-alpha, LT-beta, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LT beta R), and herpes virus entry mediator (HVEM) to control a wide range of innate and adaptive immune response functions. (nih.gov)
  • Fas/Apo1 (CD95), a receptor of the TNF receptor family activated by a distinct ligand, induces death in cells through mechanisms shared with CD120a. (nih.gov)
  • 21 Thus, it is possible that the variety of responses to MIP-1α is a reflection of both the receptor ligand interaction and the intracellular signaling cascades elicited as a consequence of ligand binding. (bloodjournal.org)
  • These eight compounds did not increase Fas surface levels and also sensitized PPC-1 cells to apoptosis induced by TNF-family member TNF-related apoptosis-inducing ligand, consistent with a post-receptor mechanism. (aacrjournals.org)
  • In part, these immune cells use death receptor ligands such as tumor necrosis factor α (TNFα), FAS-L, and TNF-related apoptosis-inducing ligand (TRAIL) to stimulate specific TNF-family death receptors on tumor target cells, resulting in activation of caspase-family proteases and triggering apoptosis ( 1 - 4 ). (aacrjournals.org)
  • Since TR6 lacks a transmembrane domain, it can function as an inhibitor by competing with the signal-transducing receptor for the ligand. (asm.org)
  • BACKGROUND: The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor, DR5, mediates proapoptotic signals and is implicated in the pathogenesis of many neoplasms including nonsmall-cell lung cancer (NSCLC). (garvan.org.au)
  • The various receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) are located on chromosome 8p21.2 , a region frequently deleted in ovarian cancer. (aacrjournals.org)
  • A considerable amount of effort has been put into the mutational analysis of receptors for apoptosis-inducing proteins, including those for tumor necrosis factor (TNF)-related apotosis inducing ligand (TRAIL), but definite mutations are rare. (aacrjournals.org)
  • Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. (neuromics.com)
  • Bidirectional signalling has been demonstrated for the CD137 receptor/ ligand system. (biovendor.com)
  • TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists are attractive anti-tumor agents because of their capability to induce apoptosis in cancer cells by activating death receptors (DR) 4 and 5 with little toxicity against normal cells. (biomedcentral.com)
  • Previously, we reported that basal B subtype TNBC cell lines were effectively killed by glutathione-S-transferase (GST)-tagged tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), while cell lines representative of the other subtypes of breast cancer remained comparatively resistant [ 9 ]. (biomedcentral.com)
  • Insights into the efficacy of golimumab plus methotrexate in patients with active rheumatoid arthritis who discontinued prior anti-tumour necrosis factor therapy: post-hoc analyses from the GO-AFTER study. (umassmed.edu)
  • Signaling within the cell initiates a pathway that turns on a protein called nuclear factor kappa B that triggers inflammation and leads to the production of immune system proteins called cytokines. (medlineplus.gov)
  • Tumor necrosis factors (TNF) alpha and beta are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. (pnas.org)
  • Macrophages of the innate immune system have Toll-like receptors (TLRs) that recognize bacterial components such as lipopolysaccharide (LPS) and initiate signaling cascades that lead to the production of inflammatory cytokines. (sciencemag.org)
  • Our results suggest that inhibitory cytokines produced by the bone marrow microenvironment are likely to be involved in the regulation of MIP-1 receptor expression on hematopoietic cells. (bloodjournal.org)
  • MIP-1α receptor expression on the cell surface of CD34 + cells was found to be associated with cell cycling and can be upregulated by the inhibitory cytokines tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). (bloodjournal.org)
  • Increasing evidence indicates that factors such as oxidative stress, plasma homocysteine increase and glutathione depletion, elevated pro-inflammatory cytokines and advanced glycation end products can play a role in Alzheimer's disease (AD) pathogenesis. (unboundmedicine.com)
  • Cytokines, such as tumor necrosis factor (TNF)-α, interleukin-1, interleukin-2, interleukin-6, and interleukin-10, have been shown to be involved in different cardiac diseases and in the complex syndrome of heart failure ( 11 ). (aacrjournals.org)
  • The direct pathogenic effects of TNFα are amplified by its ability to induce other proinflammatory cytokines, such as interleukin 1, granulocyte macrophage colony stimulating factor, platelet derived growth factor, prostaglandin E 2 , and matrix metalloproteinases, involved in the degradation of synovial tissue. (bmj.com)
  • There are three cytokines, interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha (TNFα), which have emerged to have a major role in the CNS and in different CNS disorders. (omicsonline.org)
  • but recent work from our laboratory has shown the receptors for these cytokines may also be an important factor in neuroinflammation mediated CNS disorders, because these receptors are solely localized to neurons and are modified when their ligands levels are elevated. (omicsonline.org)
  • Research has shown cytokines play an important role in mediating the effects of LPS, with specific interest in interleukin (IL)-1, IL-6 and tumor necrosis factor alpha (TNFα). (omicsonline.org)
  • IL-17 also reportedly induces hematopoietic cytokines such as GM-CSF, leukemia inhibitory factor, and IL-6 7 . (pubmedcentralcanada.ca)
  • Like TNF and IL-1, which elicit similar cellular responses, IL-17 also activates the transcription factors nuclear factor (NF)-κB and activator protein (AP)-1, important mediators of gene regulatory activities exhibited by proinflammatory cytokines 6 12 13 14 . (pubmedcentralcanada.ca)
  • Among the proinflammatory cytokines induced, tumor necrosis factor alpha (TNF-α) has been shown to be crucial for the eradication of bacteria in several experimental models ( 10 , 11 ). (asm.org)
  • Tumor necrosis factors (TNF family) refer to a group of cytokines which are mainly secreted by macrophages and can induce cell death of certain tumor cell lines. (sinobiological.com)
  • This protein is an osteoblast-secreted decoy receptor that fun. (nih.gov)
  • Modulation of TREM-1 in TNF-α-treated pSMCs by the administration of TREM-1 decoy receptor rTREM-1/Fc, monoclonal antibodies, or siRNA to TREM-1 attenuated the expression of MMPs and Col I (α1) and Col III (α1) in both S and AS groups. (ahajournals.org)
  • Tumor necrosis factor (TNF) receptor 6/decoy receptor 3 (TR6/DcR3) is an antiapoptosis soluble receptor of the TNF family produced by tumor cells. (asm.org)
  • Tumor necrosis factor (TNF) receptor 6 (TR6), also called decoy receptor 3 (DcR3) or M68, is a member of the TNF receptor family that is produced as a secreted protein ( 3 , 25 , 35 ). (asm.org)
  • Because of TR6 overexpression in a substantial number of tumors ( 23 , 28 ), it has been postulated that the decoy receptor promotes the survival of tumor cells by helping them to escape FasL-dependent cell death ( 3 , 25 ). (asm.org)
  • Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands. (mybiosource.com)
  • TRAPS is due to a gene defect in a protein called tumor necrosis factor receptor, which leads to an increase of the patient's normal inflammatory response. (rheumatology.org)
  • In addition, most TNF receptors require specific adaptor protein such as TRADD , TRAF , RIP and FADD for downstream signalling. (wn.com)
  • This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2 , which possess E3 ubiquitin ligase activity. (wn.com)
  • This protein is one of the major receptors for the tumor necrosis factor-alpha . (wn.com)
  • Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. (wn.com)
  • To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, the effects of ovariectomy were explored in six-month-old transgenic mice expressing high blood levels of a soluble TNF receptor type I (sTNFR1)-FcIgG3 fusion protein, which neutralizes TNF alpha, and in their nontransgenic littermates used as controls. (jci.org)
  • Neuronal damage was decreased with i.c.v. injection of TNFalpha antibody and in TNFp55R-/-p75R-/- mice that showed higher constitutive mRNA levels for interleukin (IL-1alpha), macrophage inflammatory protein 1-alpha (MIP-1alpha), TNFalpha, transforming growth factor beta1, Fas, and TNFRSF6-assoicated via death domain (FADD). (sigmaaldrich.com)
  • Chemokines elicit their effects on primitive hematopoietic cells via G-protein-coupled receptors, several of which have recently been cloned. (bloodjournal.org)
  • Biochemical studies of cardiac tissues showed cytochrome c release and the increase in proapoptotic protein levels, suggesting that lack of TNF-α receptor I and II exacerbates Adriamycin-induced cardiac injury. (aacrjournals.org)
  • The G protein-coupled serotonin 5-hydroxytryptamine (5-HT) 2A receptor is primarily recognized for its role in brain neurotransmission, where it mediates a wide variety of functions, including certain aspects of cognition. (aspetjournals.org)
  • TNF induces the trimerization of its type I receptor (the major signaling receptor relative to the type II receptor), which initiates a signaling cascade engaging the adapter TRADD (TNF receptor-associated death domain protein), the serine/threonine kinase RIP (receptor-interacting protein), and TNF receptor-associated factor (TRAF)2 27 28 29 . (pubmedcentralcanada.ca)
  • IL-1 induces the heterocomplex formation of two different receptor chains, the type I receptor (IL-1R1) and the receptor accessory protein (IL-1RAcp) 30 31 32 . (pubmedcentralcanada.ca)
  • Among the many factors that determine the pathogenicity of S. aureus , protein A, a surface protein, acts as an exceptionally complex virulence factor, contributing to the success of S. aureus as a pathogen by interfering with immune clearance and also by inducing inflammation. (asm.org)
  • Monocytes and myeloid-derived dendritic cells (MDC) released the protein exclusively following stimulation of Toll-like receptor 2 (TLR2) and TLR4 by gram-positive and gram-negative bacterial antigens. (asm.org)
  • In the present study, we extended this previous observation by comparing the effect of Tg and other calcium-mobilizing G-protein-coupled receptor (GPCR) agonists on the expression of different pro-inflammatory genes in response to tumor necrosis factor (TNF)-alpha in ASM cells. (le.ac.uk)
  • Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein. (neuromics.com)
  • The increased interleukin-10 production was analyzed in terms of intracellular signaling in peripheral blood mononuclear cells from patients with trauma: our results suggest the involvement of p38 mitogen-activated protein kinase, Sp-1 transcription factor, heterotrimeric Gi protein, and phosphatidylinositol-3′-kinase. (pasteur.fr)
  • Approximately 60-70% of breast cancers are estrogen receptor (ER) or progesterone receptor (PR) positive, and 15-30% of cases have gene amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) protein [ 2 ]. (biomedcentral.com)
  • OBJECTIVE: Mice lacking the tumor necrosis factor-alpha receptor 2 (TNFR2) gene fed a high-fat diet gain less weight and display reduced leptin and insulin levels. (diabetesjournals.org)
  • In this study, we show that PS50G modulate the frequency and phenotype of regulatory T cells (Treg) in the lung, specifically increasing the proportion of tumor necrosis factor 2 (TNFR2) expressing Treg. (edu.au)
  • TNF-receptors are modular proteins. (ebi.ac.uk)
  • However, the molecules that initiate these signaling events, including the death domain- and TNF receptor associated factor (TRAF) domain-containing adapter proteins and the signaling enzymes associated with them, are largely unique to the TNF/nerve growth factor receptor family. (nih.gov)
  • This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. (reportlinker.com)
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Intracellular signaling peptides and proteins that bind directly or indirectly to the cytoplasmic portion of TUMOR NECROSIS FACTOR RECEPTORS. (harvard.edu)
  • This graph shows the total number of publications written about "Tumor Necrosis Factor Receptor-Associated Peptides and Proteins" by people in Harvard Catalyst Profiles by year, and whether "Tumor Necrosis Factor Receptor-Associated Peptides and Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Tumor Necrosis Factor Receptor-Associated Peptides and Proteins" by people in Profiles. (harvard.edu)
  • Calcium ion regulatory proteins playing major roles in these processes include L-type voltage-dependent calcium channels (L-type VDCCs) and calcium-sensing receptors (CaRs). (nih.gov)
  • Stimuli that activate the intrinsic pathway include DNA-damaging anticancer drugs, γ-irradiation, hypoxia, and growth factor deprivation, causing mitochondria to release cytochrome c and other apoptogenic proteins into the cytosol, resulting in caspase activation ( 8 ). (aacrjournals.org)
  • Exogenous proteins, such as the soluble tumor necrosis factor receptor 1 (sTNFR1), have been shown previously to be targeted to secretory lysosomes [1]. (lu.se)
  • The localization and amount of TNF-α, TNF-α receptor 1 and 2 proteins were analysed by immunohistochemistry and western blot after 24 and 48 h of organ culture and at 48 h following SAH or MCAO. (biomedcentral.com)
  • While recruitment of TRAF family proteins can lead to the activation of transcription factors such as, NF-kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses. (sinobiological.com)
  • Tumour necrosis factor α (TNFα) is supposed to have a pivotal role in the pathogenesis of rheumatoid arthritis (RA). (bmj.com)
  • The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to tumour necrosis factor (TNF) antagonist therapy. (bmj.com)
  • Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. (jrheum.org)
  • OBJECTIVE: To investigate whether polymorphisms in the tumor necrosis factor receptor I (TNFRSF1A) and receptor II (TNFRSF1B) genes are associated with the anemia observed in rheumatoid arthritis (RA). (jrheum.org)
  • Tumor necrosis factor (TNF) promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and refractory asthma. (sinobiological.com)
  • In vitro binding assays revealed that TRAF5 associates with the cytoplasmic tail of CD40, but not with the cytoplasmic tail of tumor receptor factor receptor type 2, which associates with TRAF2. (pnas.org)
  • Microscopical examination revealed a characteristic staining of the cytoplasmic cell membrane for all three receptor subtypes. (bloodjournal.org)
  • Furthermore, we demonstrate that CD34 + cells express the three MIP-1α-binding chemokine receptors CCR-1, CCR-4, and CCR-5 on their cytoplasmic cell membranes. (bloodjournal.org)
  • TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. (neuromics.com)
  • Among the cancer patients, the incidence of increase in the concentrations of soluble TNF receptors (about 70%) greatly exceeded that of the serum carcinoembryonic antigen (about 26%), a commonly used cancer marker. (aacrjournals.org)
  • We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. (rupress.org)
  • Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). (sumobrain.com)
  • Here, we show that although death is mediated by TNF-α and its receptor (TNF-RII), surprisingly neither the antigen dose dependence of TNF-α production nor that of TNF-RII expression can account for the dose dependence of apoptosis. (ovid.com)
  • Purified TNFR-IgG binds to both TNF-alpha and TNF-beta and exhibits 6- to 8-fold higher affinity for TNF-alpha than cell surface or soluble TNF receptors. (pnas.org)
  • Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. (uniprot.org)
  • The transaction complements Promethera's pipeline with an innovative antibody-based drug candidate that specifically binds to the tumor necrosis factor receptor 1 (TNF-R1). (businesswire.com)
  • The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. (rupress.org)
  • TRAIL binds to two cell-death-inducing (DR4 and DR5) and two decoy (DcR1, and DcR2) receptors. (biomedcentral.com)
  • Molecular cloning and expression of a receptor for human tumor necrosis factor" (PDF). (wikipedia.org)
  • Two major pathways for apoptosis have been identified, involving either mitochondria ( intrinsic ) or tumor necrosis factor (TNF)-family death receptors ( extrinsic ) as initiators of caspase protease activation and cell death. (aacrjournals.org)
  • A limitation of such therapies, however, is acquired or intrinsic resistance to TNF-family death ligands and death receptors, which commonly occurs in advanced malignancies ( 6 ). (aacrjournals.org)
  • Therefore, small molecules that restore sensitivity of tumor cells to TNF-family death receptors could be useful therapeutic adjuncts to new biological agents such as recombinant TRAIL and tumor vaccines. (aacrjournals.org)
  • TNF-family death receptors trigger apoptosis through a mechanism involving recruitment of certain caspase-family proteases to their cytosolic domains (e.g., caspases 8 and 10 in humans), resulting in formation of a death-inducing signaling complex. (aacrjournals.org)
  • The functional TRAIL receptors death receptors 4 ( DR4, TRAIL-R1 ) and 5 ( DR5, TRAIL-R2/TRICK2/KILLER ), and decoy receptors 1 ( DcR1, TRAIL-R3/TRID ) and 2 ( DcR2, TRAIL-R4/ TRUNDD) with thus far little known physiologic function are all located on chromosome 8p21.2 according to the University of California Santa Cruz Human Genome Project Working Draft June 2002 ( http://genome.cse.ucsc.edu ). (aacrjournals.org)
  • Aronica et al 20 showed that treatment of Mo7e cells with MIP-1α inhibits upregulation of Raf-1 kinase activity in response to granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem-cell factor (SCF). (bloodjournal.org)
  • Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor. (diabetesjournals.org)
  • XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. (ebi.ac.uk)
  • With the TNF-alpha pathway and its Receptor 1 (R1) being implicated in the progression of many inflammatory diseases, including chronic liver diseases leading to fibrosis, a therapeutic antibody approach is a valuable strategy in its own right as well as in combination with Promethera's cell-based medicines such as the HepaStem technology. (businesswire.com)
  • Toxoplasma GRA15 Activates the NF-?B Pathway through Interactions with TNF Receptor-Associated Factors. (harvard.edu)
  • Characterization of the effects of the eight compounds on a panel of 10 solid tumor cell lines revealed two structurally distinct compounds that frequently sensitize to extrinsic pathway agonists. (aacrjournals.org)
  • Altogether, these findings show the feasibility of identifying compounds that selectively enhance apoptosis via the extrinsic pathway, thus providing research tools for uncovering resistance mechanisms and a starting point for novel therapeutics aimed at restoring sensitivity of tumor cells to immune effector mechanisms. (aacrjournals.org)
  • These results suggested that TNF-α receptors play a critical role in cardioprotection by suppression of the mitochondrial-mediated associated cell death pathway. (aacrjournals.org)
  • Our results showed that TNF-α signaling via its receptor I and II pathway may suppress both the extrinsic and intrinsic apoptosis pathways leading to the protection of mitochondria against Adriamycin-induced cardiac injury. (aacrjournals.org)
  • Because the soluble form of TNFRp55 neutralizes TNF in cytotoxic assays, and is functionally active as a TNF antagonist (12), alteration of the TNFRp55 signaling pathway might be a key factor in the pathogenesis of scleroderma. (docme.ru)
  • The present study shows that cerebral ischemia and organ culture induce expression of TNF-α and its receptors in the walls of cerebral arteries and that upregulation is transcriptionally regulated via the MEK/ERK pathway. (biomedcentral.com)
  • Therefore, we investigated a number of ovarian cancer cell lines for expression of players in the TRAIL pathway and could show that the lack of expression of DR4 correlated with resistance to TRAIL, whereas the expression of other receptors did not ( 7 ). (aacrjournals.org)
  • Detailed evaluation of this and related molecules revealed that compounds in this class are "photochemically enhanced" inhibitors, in that they bind reversibly to the TNFRc1 with weak affinity (ca. 40-100 microM) and then covalently modify the receptor via a photochemical reaction. (rcsb.org)
  • cell surface receptors that bind tumour necrosis factor and trigger changes which influence the behaviour of cells . (biology-online.org)
  • Both receptors bind both alpha and beta tumour necrosis factors with high affinity , and both are members of the nerve growth factor receptor family . (biology-online.org)
  • The soluble forms of these receptors can bind to TNFα, neutralizing its effects. (edu.mt)
  • 14-17 MIP-1α has been shown to bind to at least three of these receptors, designated chemokine receptors CCR-1, CCR-4, and CCR-5. (bloodjournal.org)
  • references ( 2 )( 3 )( 4 )( 5 )) is expressed in monocytes, macrophages, and dendritic cells ( 2 )( 3 )( 5 ) and has been shown to bind to B cells and increase the proliferation of B cells in combination with an anti-B cell receptor antibody in vitro ( 2 )( 5 ). (rupress.org)
  • OBJECTIVE To test synovial fluid (SF) for the presence of soluble fragments originating from distinct tumor necrosis factor receptors (TNF-sR55 and TNF-sR75) which bind to TNF and inhibit its biologic activity. (semanticscholar.org)
  • No previous works have studied levels of soluble tumour necrosis factor-α receptor (sTNFR)-1 in patients with OSA. (ersjournals.com)
  • Here we describe a potent TNF antagonist, a TNF receptor (TNFR) immunoadhesin, constructed by gene fusion of the extracellular portion of human type 1 TNFR with the constant domains of human IgG heavy chain (TNFR-IgG). (pnas.org)
  • Our study suggests that, signaling through p75 receptor is required for collateral vessel development in ischemia-induced neovascularization as well as plays a critical role in muscle regeneration and suggest a potential gene target, which could be used to improve the repair of ischemic tissue in adults. (ahajournals.org)
  • Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients. (diabetesjournals.org)
  • 4 2 Comparative gene expression profiling of CLL cells isolated from peripheral blood (PB), bone marrow (BM) and lymph nodes (LN) further identified enhanced B-cell receptor (BCR)-mediated signaling and nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) activity in the lymphoid microenvironment compared to blood. (haematologica.org)
  • TRAF5 has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus and is most homologous to TRAF3, also known as CRAF1, CD40bp, or LAP-1, a previously identified CD40-associated factor. (pnas.org)
  • In contrast to TRAF3, overexpression of TRAF5 activates transcription factor nuclear factor kappa B. Furthermore, amino-terminally truncated forms of TRAF5 suppress the CD40-mediated induction of CD23 expression, as is the case with TRAF3. (pnas.org)
  • Upon receptor engagement, TRAF2 is recruited to CD40 and translocates to lipid rafts in a RING finger-dependent process, which enables the activation of downstream signaling cascades including c-Jun NH 2 -terminal kinase (JNK) and nuclear factor (NF)-κB. (rupress.org)
  • Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. (ebi.ac.uk)
  • 14-18 MIP-1α binding to these receptors is associated with transient elevations of intracellular calcium levels [Ca 2+ ] i , which has been used as an indicator of receptor activation. (bloodjournal.org)
  • Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces soluble tumor necrosis factor receptor production through tumor necrosis factor alpha-converting enzyme activation. (umassmed.edu)
  • We have now discovered that activation of 5-HT 2A receptors in primary aortic smooth muscle cells provides a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-α-mediated inflammation. (aspetjournals.org)
  • Our results indicate that activation of 5-HT 2A receptors represents a novel, and extraordinarily potent, potential therapeutic avenue for the treatment of disorders involving TNF-α-mediated inflammation. (aspetjournals.org)
  • Here we report the requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in IL-17-induced NF-κB and JNK activation. (pubmedcentralcanada.ca)
  • sTNFR1-tm-Y was targeted directly from the Golgi to secretory lysosomes, followed by generation of membrane-free sTNFR1, whose secretion could be triggered by a Ca2+ ionophore or inummoglobulin E receptor activation. (lu.se)
  • Interestingly, TNF-alpha-induced interferon regulatory factor (IRF)-1 activation was significantly inhibited by all calcium-mobilizing agents, BK, Thr and Tg. (le.ac.uk)
  • Our results thus suggest that TNF-α delays human eosinophil apoptosis via TNF-receptor 1 and the resulting changes in longevity depend on yin-yang balance between activation of NF-κB and AP-1. (uta.fi)
  • Co-stimulation through CD137 enhances T lymphocyte activation and may enable rejection of tumors in vivo. (biovendor.com)
  • Although each receptor induces distinct intracellular signals, they also have co-operative and overlapping effects. (edu.mt)
  • TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. (biomedcentral.com)
  • Despite the recognized role of tumor necrosis factor (TNF) in inflammation and neuronal degeneration, anti-TNF therapeutics failed to treat neurodegenerative diseases. (nih.gov)
  • TNF receptors are primarily involved in apoptosis and inflammation , but they can also take part in other signal transduction pathways, such as proliferation , survival, and differentiation . (wn.com)
  • This receptor can activate the transcription factor NF-κB , mediate apoptosis , and function as a regulator of inflammation . (wn.com)
  • The binding of tumor necrosis factor alpha (TNF-alpha) to the type-1 TNF receptor (TNFRc1) plays an important role in inflammation. (rcsb.org)
  • Proteolytic cleavage of the tumor necrosis factor (TNF) receptor (TNFR) from the cell surface contributes to anti-inflammatory responses and may be beneficial in reducing the excessive inflammation associated with multiple organ failure and mortality during sepsis. (sciencemag.org)
  • In multivariable Cox regression models adjusted for inflammation, lifestyle and established cardiovascular risk factors, one standard deviation (SD) higher sTNFR1 was associated with a hazard ratio (HR) for mortality of 1.37, 95% confidence interval (CI) 1.17-1.60, in PIVUS and HR 1.22, 95% CI 1.10-1.37 in ULSAM. (diva-portal.org)
  • This receptor activates NF-kappaB, mediate apoptosis and function as a regulator of inflammation. (reportlinker.com)
  • Tumor necrosis factor (TNF) affects the growth, differentiation, and function of a multitude of cell types that are mediators of inflammation and cellular immune responses. (docme.ru)
  • This inhibition was proportional to the content of soluble TNF receptors and could be fully abolished by the addition to the sera of specific antibodies against the receptors. (aacrjournals.org)
  • The expression of the MIP-1 receptor subtypes on LP CD34 + cells was studied by indirect immunofluorescence using specific antibodies for the detection of CCR-1, CCR-4, and CCR-5. (bloodjournal.org)
  • Attempts to exploit these immune effector molecules as anticancer agents have resulted in early-stage clinical trials using a recombinant soluble fragment of TRAIL and agonistic monoclonal antibodies targeting TRAIL receptors (reviewed in ref. 5 ). (aacrjournals.org)
  • Presence of functional oxytocin receptors in cultured human myoblasts," The Journal of Clinical Endocrinology & Metabolism , vol. 87, no. 3, pp. 1415-1418, 2002. (hindawi.com)
  • TNF-α soluble receptors have also been linked to disorders in glucose metabolism 9 , and sTNFR-1 is probably an important regulator of sleep-wake cycles 10 . (ersjournals.com)
  • We aimed to explore and validate the association between sTNFR1 and mortality, and to explore the influence of other established risk factors for mortality, including other inflammatory markers. (diva-portal.org)
  • Soluble tumor necrosis factor receptors in human inflammatory synovial fluids. (semanticscholar.org)
  • Tumor necrosis factor receptor-associated factor (TRAF)2 is a critical adaptor molecule for tumor necrosis factor (TNF) receptors in inflammatory and immune signaling. (rupress.org)
  • Tumoral necrosis factor α plays a central role in both the inflammatory response and that of the immune system. (sinobiological.com)
  • The serum concentration of the soluble TNF receptor p55 (TNFRp55) correlates with the severity of the disease (11-13). (docme.ru)
  • Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome . (wn.com)
  • Signaling through its widely distributed cell surface receptor, interleukin (IL)-17 enhances the transcription of genes encoding proinflammatory molecules. (pubmedcentralcanada.ca)
  • Players in the various apoptotic pathways are well-known oncogenes but also intriguing candidates for tumor suppressor genes. (aacrjournals.org)
  • We wanted to further explore our observation for its true physiologic relevance on a more mechanistic level, and test whether the lack of expression of DR4 in ovarian cancer cell lines is a genetic or epigenetic phenomenon, because a variety of tumor suppressor genes have been shown to be silenced in human cancers ( 10 ). (aacrjournals.org)
  • 18 19 The signal transduction pathways further downstream of the receptors have only been partially elucidated. (bloodjournal.org)
  • Tumor necrosis factor (TNF)-alpha is postulated to play a major role in the pathogenesis of obesity-linked insulin resistance, probably resulting from an interaction with insulin signaling pathways. (diabetesjournals.org)
  • Diverse mechanisms can create roadblocks to apoptosis within the extrinsic or intrinsic pathways, occurring commonly in many cancers during tumor progression and thus creating impediments to successful treatment. (aacrjournals.org)
  • In vitro studies using co-cultures of CLL and non-malignant accessory cells mirrored this dependency, and identified several CLL-relevant factors and pathways. (haematologica.org)
  • Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. (ebi.ac.uk)
  • The main biological actions of TNF-α are initiated by binding to two distinct receptors, TNFR-I (p55) and TNFR-II (p75). (aacrjournals.org)
  • The mutations we studied are associated with clinically distinct forms of TNF receptor-associated periodic syndrome (TRAPS). (semanticscholar.org)
  • Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. (jimmunol.org)
  • Stimulation of TNF receptor-1 with TNF-α enhanced nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) activity and viability of chronic lymphocytic leukemia cells, which was inhibited by wogonin. (haematologica.org)
  • We previously reported a potential mechanism for this deletion: tumor necrosis factor (TNF)-α-mediated apoptosis resulting from stimulation with supraoptimal peptide-major histocompatibility complex. (ovid.com)
  • TRAF1 − / − dendritic cells show attenuated responses to secondary stimulation by TRAF2-dependent factors and increased stimulus-dependent TRAF2 degradation. (rupress.org)
  • The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 ( TRAF2 ), which mediates anti-apoptotic signals. (wn.com)
  • Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. (wn.com)
  • The origin of the serum soluble TNF receptors in cancer patients and the physiological implications of their effect on TNF function remain to be elucidated. (aacrjournals.org)
  • b) The decrease in the serum TNF-alpha and increase in the serum soluble TNF receptors, particularly sTNF-RII showed a positive correlation with the neurological recovery in GBB patients following treatment. (pptaglobal.org)
  • Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy," Cell , vol. 117, no. 3, pp. 399-412, 2004. (hindawi.com)
  • Vasopressin and insulin-like growth factors synergistically induce myogenesis in serum-free medium," Cell Growth & Differentiation , vol. 9, no. 2, pp. 155-163, 1998. (hindawi.com)
  • Soluble forms of the two molecular species of the cell surface receptors for tumor necrosis factor (TNF) have been detected in normal urine. (aacrjournals.org)
  • Several lines of evidence are provided to show that progesterone regulates luteal cell survival: 1) CL and LECs express progesterone receptor mRNA, 2) physiological levels of the steroid abolished TNFα-induced PCD of LECs, and 3) progesterone-producing cells are protected from PCD. (bioone.org)
  • 8 S ince the soluble forms of TNF receptors can compete with the cell-associated TNF-receptors for TNF, it was suggested that they may function as inhibitors of TNF activity. (scielo.br)
  • however, excessive TNF signaling through its receptor TNFR leads to cell death and tissue damage, such as occurs during sepsis. (sciencemag.org)
  • The receptor for advanced glycation end products (RAGE) is a cell surface receptor that has been implicated in neurodegeneration, and a soluble isoform of RAGE (sRAGE) has the ability to prevent the adverse effects of RAGE signaling by acting as a decoy. (unboundmedicine.com)
  • TNF and IL-1 signal through different cell surface receptors and utilize different sets of receptor-proximal signaling molecules. (pubmedcentralcanada.ca)
  • The levels of two soluble TNF receptors (sTNFR-p55 and sTNFR-p75), the extracellular domains of the two cell surface receptors for TNF, were elevated in the acute-stage plasma samples from 20 patients with serologically confirmed MSF. (asm.org)
  • Here, we compare the expression levels of TRAIL and its receptors in normal oral mucosa (NOM), oral premalignancies (OPM), and primary and metastatic oral squamous cell carcinomas (OSCC) in order to characterize the changes in their expression patterns during OSCC initiation and progression. (biomedcentral.com)
  • DNA microarray, immunoblotting and immunohistochemical analyses were used to examine the expression levels of TRAIL and its receptors in oral epithelial cell lines and in archival tissues of NOM, OPM, primary and metastatic OSCC. (biomedcentral.com)
  • TNF-α acts by binding to its receptors, TNF-R1 (p55) and TNF-R2 (p75), on the cell surface. (biomedcentral.com)
  • Defects in programmed cell death (apoptosis) mechanisms play an important role in tumor pathogenesis by enabling neoplastic cells to escape from cell autonomous or immunologic growth control mechanisms ( 1 ). (aacrjournals.org)
  • Tumor necrosis factor α (TNF) has recently emerged as the primary neuroinflammatory mediator that can elicit dopaminergic cell death in PD. (biomedcentral.com)
  • Selective tumour necrosis factor receptor-1 inhibition in acute lung injury: a new hope or a false dawn? (bmj.com)
  • Transplantation of WT BM mononuclear cells (MNC) into gamma-irradiated p75KO mice one month prior to HL surgery prevented limb loss and preserved limb muscle mass, suggesting that ischemia-induced neovascularization is mediated, at least in part, via p75 TNF receptor expressed in BM derived cells. (ahajournals.org)
  • It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. (curehunter.com)
  • Both dentate granule cells and CA pyramidal cells express TNF receptors (TNFR) at low levels in a punctate pattern. (sigmaaldrich.com)
  • To investigate whether the action of MIP-1 may be regulated at the cellular receptor level, we studied the expression and modulation of MIP-1 receptors on CD34 + cells isolated from normal bone marrow (NBM), umbilical cord blood (CB), and leukapheresis products (LP). Expression of MIP-1 receptors on CD34 + cells was analyzed by two-color flow cytometry using a biotinylated MIP-1 molecule. (bloodjournal.org)
  • Culture of LP CD34 + cells for 24 to 36 hours in the presence of tumor necrosis factor- (TNF-) and interferon-γ (IFN-γ) resulted in a significant increase in MIP-1 receptor expression. (bloodjournal.org)
  • As the action of MIP-1α may be regulated at the cellular receptor level, we studied the expression and modulation of MIP-1α receptors in hematopoietic CD34 + cells. (bloodjournal.org)
  • We show that CD34 + cells, from normal bone marrow, umbilical cord blood, and leukapheresis products, exhibit comparable receptor levels as determined by flow cytometric analysis of biotinylated MIP-1α binding to CD34 + cells. (bloodjournal.org)
  • Because tumor resistance to TNF-family death receptor ligands is a common problem, helping malignant cells evade host immune defenses, we sought to identify compounds that selectively sensitize resistant tumor cells to death receptor ligands. (aacrjournals.org)
  • Furthermore, the levels of IL-17 receptor (IL-17R) on the TRAF6-deficient EFs were comparable to those on the wild-type control cells. (pubmedcentralcanada.ca)
  • Sorting soluble tumor necrosis factor (TNF) receptor for storage and regulated secretion in hematopoietic cells. (lu.se)
  • Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. (haematologica.org)
  • We detected a microenvironment-induced expression of TNF receptor-1 in chronic lymphocytic leukemia cells in vitro , and an aberrantly high expression of this receptor in the proliferation centers of patients' lymph nodes. (haematologica.org)
  • The treatment of full-blown leukemia resulted in the loss of the TNF receptor-1 on chronic lymphocytic leukemia cells and their mobilization to blood. (haematologica.org)
  • Tumor necrosis factor-α (TNFα) stimulates the expression of intercellular adhesion molecule-1 (ICAM-1) by activating the transcription factor nuclear factor-κB (NF-κB) in human airway smooth muscle (ASM) cells. (aspetjournals.org)
  • In addition to the central neuroinhibitory action of midazolam, it also interferes the synthesis of nitric oxide and tumor necrosis factor-α (TNF-α) generated by activated microglial cells, blood monocytes, and mast cells, 7-9 suggesting an inhibitory action on proinflammatory mediators. (asahq.org)
  • Apoptotic rates of tumor cells and tumor-infiltrating lymphocytes (TIL) in OSCC specimens were determined by cleaved caspase 3 immunohistochemistry. (biomedcentral.com)
  • There was no significant association between TRAIL-R expression and OSSC histology grade, nodal status or apoptosis rates of tumor cells and TIL. (biomedcentral.com)
  • Lack of expression of TRAIL receptor 1 (death receptor 4, DR4) correlates with resistance to TRAIL-induced apoptosis in ovarian cancer cells. (aacrjournals.org)
  • When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. (neuromics.com)
  • Targeted inhibition of proinflammatory molecules such as tumour necrosis factor (TNF)-α would seem a logical and fruitful line of investigation for disease-modifying intervention in ARDS. (bmj.com)
  • Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy," BioMed Research International , vol. 2014, Article ID 235426, 14 pages, 2014. (hindawi.com)
  • Skeletal muscle regeneration in mice is stimulated by local overexpression of V1a-vasopressin receptor," Molecular Endocrinology , vol. 25, no. 9, pp. 1661-1673, 2011. (hindawi.com)
  • Overexpression of a dominant negative TNF receptor-associated factor 2 construct, lacking the NH 2 -terminal RING finger, completely abrogated both TNFα- and htr-9-mediated increases in NF-κB reporter activity. (aspetjournals.org)
  • 10 The extracellular portions of these receptors may constitute soluble forms (sTNFR1 and sTNFR2) and can be measured in the circulation. (scielo.br)
  • Tumor necrosis factor-α (TNF-α) and soluble TNF receptors (sTNFR1 and sTNFR2) have been implicated in infectious diseases. (ajtmh.org)
  • We investigated dynamic changes among TNF-α, membrane TNF receptors (mTNFR1 and mTNFR2), and sTNFR1 and sTNFR2 levels for patients with dengue hemorrhagic fever (DHF) and those not infected during a DEN-2 outbreak in southern Taiwan in 2002-2003. (ajtmh.org)
  • However, prospective data concerning the relation between circulating soluble tumor necrosis factor receptor-1 (sTNFR1) and mortality in humans are lacking. (diva-portal.org)
  • Circulating soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) are associated with chronic kidney disease (CKD) progression in patients with CKD or diabetes, and with higher mortality. (diva-portal.org)
  • TNFp55R (55 kDa type-1 TNFR) and TNFp75R (75 kDa type-2 TNFR) immunoreactivity in AC3(+) neurons displayed a pattern suggestive of receptor internalization and a temporal sequence of expression of TNFp55R followed by TNFp75R associated with the progression of apoptosis. (sigmaaldrich.com)
  • Differential expressions of TRAIL receptors in OSCC do not appear to play a crucial role in their apoptotic rate or metastatic progression. (biomedcentral.com)
  • Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome. (semanticscholar.org)
  • Although it has been well documented that IL-17 activates the transcription factor nuclear factor (NF)-κB and c-Jun NH 2 -terminal kinase (JNK), the upstream signaling events are largely unknown. (pubmedcentralcanada.ca)
  • Receptor shedding is thought to be protective by reducing cellular responses to TNF and by binding to and sequestering extracellular TNF. (sciencemag.org)
  • Later in the course of the response, TGF␤ is primarily associated with extracellular matrix production and up-regulation of platelet-derived growth factor (PDGF) receptors in the scleroderma fibroblast (1). (docme.ru)
  • Among smokers, high DR5 and tumor stage were independent predictors of reduced disease-free survival in multivariate analysis, however, DR5 was not an independent prognostic marker among the entire cohort of NSCLC. (garvan.org.au)
  • In the MFP model, weekly treatment with 0.1 or 0.3 mg/kg MEDI3039 for 5 weeks inhibited tumor growth by 99.05% or 100% (median), respectively, compared with the control group, and extended animal survival ( p = 0.08 or p = 0.0032 at 0.1 or 0.3 mg/kg, respectively). (biomedcentral.com)
  • Unlike the molecularly targeted treatment strategies available for hormone receptor expressing or HER2 amplified subsets of breast cancer, effective targeted therapies for TNBC that improve survival have yet to be developed, and cytotoxic chemotherapy remains the main therapy for TNBC [ 4 ]. (biomedcentral.com)
  • During bacterial infection of the bloodstream (sepsis), TNF-alpha induction by bacterial endotoxin is thought to be a major factor contributing to the cardiovascular collapse and critical organ failure that can develop. (pnas.org)
  • Cardiomyopathy is a major dose-limiting factor for applications of Adriamycin, a potent chemotherapeutic agent. (aacrjournals.org)
  • The inhibitory action of TNF-alpha was dose-dependent, already detectable at 10 pmol/l, and was correlated to inhibition of tyrosine phosphorylation of IRS-1 with an unaltered autophosphorylation of the insulin receptor beta-subunit. (diabetesjournals.org)
  • Complement receptor-mediated uptake and tumor necrosis factor-alpha-mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages. (jimmunol.org)
  • Using enzyme-linked immunosorbent assays for these soluble receptors, we determined their levels in the sera of 40 healthy subjects and 59 patients with solid tumors. (aacrjournals.org)
  • Adriamycin (common name doxorubicin) is a prototype of anthracycline antibiotics that has been widely used as a chemotherapeutic agent since the late 1960s for hematologic and solid tumors. (aacrjournals.org)
  • The protective role of TNF receptor I and II was directly confirmed in isolated primary cardiomyocytes. (aacrjournals.org)
  • Is the Subject Area "Transcription factors" applicable to this article? (plos.org)
  • Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. (ajtmh.org)
  • To determine the role of tumor necrosis factor receptor p55 (TNFRp55)-mediated signaling in the pathogenesis of scleroderma. (docme.ru)
  • Between days 7 and 10 post-HL surgery 100% of old p75KOs experienced auto-amputation of the operated limbs, whereas none of the age-matched WT mice exhibited HL necrosis. (ahajournals.org)
  • We observed mild to moderate necrosis of the distal ischemic HL in 100% of young p75KO mice beginning at day 7-14, but not evidence of HL necrosis in the young WT mice. (ahajournals.org)
  • Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. (jci.org)
  • We used mice in which both TNF receptor I and II have been selectively inactivated (DKO) with wild-type mice as controls. (aacrjournals.org)
  • To investigate whether TNF-α has a beneficial effect on Adriamycin-induced cardiac injury and elucidate its possible mechanisms, we conducted a series of studies using TNF receptor-deficient mice. (aacrjournals.org)
  • These mice display autoimmune-like manifestations including high levels of rheumatoid factors, circulating immune complexes, anti-DNA autoantibodies, and Ig deposition in the kidney ( 6 ). (rupress.org)
  • Expression of proapoptotic TRAIL-receptors DR4 and DR5 in OSCC seemed to depend, at least in part, on whether or not these receptors were expressed in their parental oral epithelia. (biomedcentral.com)
  • Multivariate analysis showed that a decrease in levels of mTNFR1 expression was the only factor significantly different between patients with DHF and those with dengue fever. (ajtmh.org)
  • However, there is significant expression of this receptor in peripheral tissues, where its importance is largely unknown. (aspetjournals.org)
  • Increased expression of DR5 correlated with poorly differentiated tumors and was inversely correlated with bronchioloalveolar carcinomas. (garvan.org.au)
  • Expression levels of DR4, DR5 and DcR1 receptors were not significantly altered in OPM, primary OSCC and metastatic OSCC compared to patient-matched normal oral mucosa. (biomedcentral.com)
  • High DR5 expression in primary OSCC correlated significantly with larger tumor size. (biomedcentral.com)
  • The aim of this study was first to investigate if there is altered expression of TNF-α and TNF-α receptors in cerebral artery walls following global or focal ischemia, and after organ culture. (biomedcentral.com)
  • The Raf and NF-κB inhibitors significantly reduced organ culture induced TNF-α expression while they had minor effects on the TNF-α receptors. (biomedcentral.com)
  • The expression of toll-like receptor (TLR) 2 was not reduced on patients' monocytes as compared with healthy control subjects, whereas that of TLR4 was reduced. (pasteur.fr)
  • With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha . (wn.com)
  • This structure clearly revealed that one of the aromatic rings of the inhibitor was covalently linked to the receptor through the main-chain nitrogen of Ala-62, a residue that has already been implicated in the binding of TNF-alpha to the TNFRc1. (rcsb.org)
  • The two recognised tumour necrosis factor receptors are designated alpha and beta receptors. (biology-online.org)
  • A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (curehunter.com)
  • The presence of a MO alpha-adrenergic receptor was established by demonstrating binding of the alpha 2-adrenergic antagonist 3H-yohimbine to membranes prepared from MO. (jimmunol.org)
  • Localized tumor necrosis factor-alpha (TNFalpha) elevation has diverse effects in brain injury often attributed to signaling via TNFp55 or TNFp75 receptors. (sigmaaldrich.com)
  • Interaction of TNF-alpha with insulin signaling was determined by quantification of insulin receptor substrate (IRS)-1-associated PI 3-kinase activity. (diabetesjournals.org)
  • Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients. (ajtmh.org)
  • Experimental evidence support soluble receptors for tumor necrosis factor alpha as important mediators of the underlying pathology leading to cardiovascular disease and cancer. (diva-portal.org)
  • Serum levels of sRAGE and TNF-alpha receptor II were not significantly different in AD or MCI patients compared to controls. (unboundmedicine.com)
  • eg, methotrexate) and biologicals (eg, tumour necrosis factor (TNF) alpha inhibitors). (bmj.com)
  • Circulating tumour necrosis factor alpha and soluble tumour necrosis factor receptors in patients with different patterns of rheumatoid synovitis. (semanticscholar.org)
  • Serum tumour necrosis factor-alpha and soluble tumour necrosis factor receptors levels in patients with Guillain-Barre syndrome. (pptaglobal.org)
  • [email protected] OBJECTIVES: To estimate the serum concentrations of Tumour Necrosis Factor alpha (TNF-alpha) and soluble TNF receptors (s TNF-RI and TNF-RII) in patients with Guillain-Barre syndrome (GBS), before and after treatment. (pptaglobal.org)