Receptors n methyl d aspartate. Medical search

The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.

Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.

One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

An enzyme that catalyzes the formation of beta-aspartyl phosphate from aspartic acid and ATP. Threonine serves as an allosteric regulator of this enzyme to control the biosynthetic pathway from aspartic acid to threonine. EC 2.7.2.4.

An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.

An enzyme that catalyzes the conversion of aspartic acid to ammonia and fumaric acid in plants and some microorganisms. EC 4.3.1.1.

A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.

Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.

The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.

Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.

An aspartate aminotransferase found in MITOCHONDRIA.

The rate dynamics in chemical or physical systems.

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).

An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.

An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.

A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.

A hydrocarbon used as an industrial solvent. It has been used as an aerosal propellent, as a refrigerant and as a local anesthetic. (From Martindale, The Extra Pharmacopoeia, 31st ed, p1403)

This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

An enzyme that catalyzes the reduction of aspartic beta-semialdehyde to homoserine, which is the branch point in biosynthesis of methionine, lysine, threonine and leucine from aspartic acid. EC 1.1.1.3.

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.

A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.

Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)

An enzyme that catalyzes the conversion of L-aspartate 4-semialdehyde, orthophosphate, and NADP+ to yield L-4-aspartyl phosphate and NADPH. EC 1.2.1.11.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.

A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.

The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (From Lehninger, Principles of Biochemistry, 1982, p442)

Derivatives of OXALOACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include a 2-keto-1,4-carboxy aliphatic structure.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine. (1/6275)

In a slice preparation of rat visual cortex, we discovered that paired-pulse stimulation (PPS) elicits a form of homosynaptic long-term depression (LTD) in the superficial layers when carbachol (CCh) or norepinephrine (NE) is applied concurrently. PPS by itself, or CCh and NE in the absence of synaptic stimulation, produced no lasting change. The LTD induced by PPS in the presence of NE or CCh is of comparable magnitude with that obtained with prolonged low-frequency stimulation (LFS) but requires far fewer stimulation pulses (40 vs 900). The cholinergic facilitation of LTD was blocked by atropine and pirenzepine, suggesting involvement of M1 receptors. The noradrenergic facilitation of LTD was blocked by urapidil and was mimicked by methoxamine, suggesting involvement of alpha1 receptors. beta receptor agonists and antagonists were without effect. Induction of LTD by PPS was inhibited by NMDA receptor blockers (completely in the case of NE; partially in the case of CCh), suggesting that one action of the modulators is to control the gain of NMDA receptor-dependent homosynaptic LTD in visual cortex. We propose that this is a mechanism by which cholinergic and noradrenergic inputs to the neocortex modulate naturally occurring receptive field plasticity. (+info)

Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (2/6275)

Persistent potentiations of the chemical and electrotonic components of the eighth nerve (NVIII) EPSP recorded in vivo in the goldfish reticulospinal neuron, the Mauthner cell, can be evoked by afferent tetanization or local dendritic application of an endogenous transmitter, dopamine (3-hydroxytyramine). These modifications are attributable to the activation of distinct intracellular kinase cascades. Although dopamine-evoked potentiation (DEP) is mediated by the cAMP-dependent protein kinase (PKA), tetanization most likely activates a Ca2+-dependent protein kinase via an increased intracellular Ca2+ concentration. We present evidence that the eighth nerve tetanus that induces LTP does not act by triggering dopamine release, because it is evoked in the presence of a broad spectrum of dopamine antagonists. To test for interactions between these pathways, we applied the potentiating paradigms sequentially. When dopamine was applied first, tetanization produced additional potentiation of the mixed synaptic response, but when the sequence was reversed, DEP was occluded, indicating that the synapses potentiated by the two procedures belong to the same or overlapping populations. Experiments were conducted to determine interactions between the underlying regulatory mechanisms and the level of their convergence. Inhibiting PKA does not impede tetanus-induced LTP, and chelating postsynaptic Ca2+ with BAPTA does not block DEP, indicating that the initial steps of the induction processes are independent. Pharmacological and voltage-clamp analyses indicate that the two pathways converge on functional AMPA/kainate receptors for the chemically mediated EPSP and gap junctions for the electrotonic component or at intermediaries common to both pathways. A cellular model incorporating these interactions is proposed on the basis of differential modulation of synaptic responses via receptor-protein phosphorylation. (+info)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/6275)

Using in situ patch-clamp techniques in rat telencephalic slices, we have followed resting potential (RP) properties and the functional expression of NMDA receptors in neocortical Cajal-Retzius (CR) cells from embryonic day 18 to postnatal day 13, the time around which these cells normally disappear. We find that throughout their lives CR cells have a relatively depolarized RP (approximately -50 mV), which can be made more hyperpolarized (approximately -70 mV) by stimulation of the Na/K pump with intracellular ATP. The NMDA receptors of CR cells are subjected to intense postnatal upregulation, but their similar properties (EC50, Hill number, sensitivity to antagonists, conductance, and kinetics) throughout development suggest that their subunit composition remains relatively homogeneous. The low RP of CR cells is within a range that allows for the relief of NMDA channels from Mg2+ blockade. Our findings are consistent with the hypothesis that CR cells may degenerate and die subsequent to uncontrolled overload of intracellular Ca2+ via NMDA receptor activation by ambient glutamate. In support of this hypothesis we have obtained evidence showing the protection of CR cells via in vivo blockade of NMDA receptors with dizocilpine. (+info)

Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors. (4/6275)

Murine cortical cultures containing both neurons and glia (days in vitro 13-15) were exposed to periods of oxygen-glucose deprivation (5-30 min) too brief to induce neuronal death. Cultures "preconditioned" by sublethal oxygen-glucose deprivation exhibited 30-50% less neuronal death than controls when exposed to a 45-55 min period of oxygen-glucose deprivation 24 hr later. This preconditioning-induced neuroprotection was specific in that neuronal death induced by exposure to excitotoxins or to staurosporine was not attenuated. Neuroprotection was lost if the time between the preconditioning and severe insult were decreased to 7 hr or increased to 72 hr and was blocked if the NMDA antagonist 100 microM 3-((D)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid was applied during the preconditioning insult. This was true even if the duration of preconditioning was increased as far as possible (while still remaining sublethal). A similar preconditioning effect was also produced by sublethal exposure to high K+, glutamate, or NMDA but not to kainate or trans-1-aminocyclopentane-1, 3-dicarboxylic acid. (+info)

Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. (5/6275)

We have used confocal microscopy to monitor synaptically evoked Ca2+ transients in the dendritic spines of hippocampal pyramidal cells. Individual spines respond to single afferent stimuli (<0.1 Hz) with Ca2+ transients or failures, reflecting the probability of transmitter release at the activated synapse. Both AMPA and NMDA glutamate receptor antagonists block the synaptically evoked Ca2+ transients; the block by AMPA antagonists is relieved by low Mg2+. The Ca2+ transients are mainly due to the release of calcium from internal stores, since they are abolished by antagonists of calcium-induced calcium release (CICR); CICR antagonists, however, do not depress spine Ca2+ transients generated by backpropagating action potentials. These results have implications for synaptic plasticity, since they show that synaptic stimulation can activate NMDA receptors, evoking substantial Ca2+ release from the internal stores in spines without inducing long-term potentiation (LTP) or depression (LTD). (+info)

Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance. (6/6275)

A brief period of sublethal cerebral ischemia, followed by several days of recovery, renders the brain resistant to a subsequent lethal ischemic insult, a phenomenon termed ischemic preconditioning or tolerance. Ischemic tolerance was established in the rat two-vessel occlusion model of ischemia, induced by occlusion of both carotid arteries in combination with hypotension. Ischemic preconditioning (3 minutes) provided maximal neuroprotection when induced 2 days prior to a lethal ischemic insult of 9-minute duration. Neuroprotection persisted for at least 8 weeks. Since neurotransmission has been implicated in ischemic cell death, the effect of ischemic preconditioning on tyrosine phosphorylation of proteins and on the levels of glutamate receptor subunits in hippocampus and neocortex was studied. Regional levels of tyrosine phosphorylation of proteins in general and the N-methyl-D-aspartate receptor subunit NR2 in particular are markedly enhanced after ischemia in nonconditioned brains, in both the synaptosomal fraction and the whole-tissue homogenate of rat neocortex and hippocampus, but recover to control levels only in the preconditioned brain. Ischemic preconditioning selectively induces a decrease in the levels of the NR2A and NR2B subunits and a modest decrease in the levels of NR1 subunit proteins in the synaptosomal fraction of the neocortex but not hippocampus after the second lethal ischemia. It was concluded that ischemic preconditioning prevents a persistent change in cell signaling as evidenced by the tyrosine phosphorylation of proteins after the second lethal ischemic insult, which may abrogate the activation of detrimental cellular processes leading to cell death. (+info)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. (7/6275)

The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and significant (P < 0.001) increase in the extracellular synaptic response by 23%. The induction of LTP was independent from activation of N-methyl-D-aspartate (NMDA) receptors, but prevented by bath application of NG-nitro-L-arginine methyl ester (L-NAME), indicating that one or several of the different NO synthases (NOS) produced NO within the postsynaptic neuron. No LTP could be induced in knockout mice lacking the endothelial NOS (eNOS) isoform. These data suggest that eNOS is involved in an NMDA receptor-independent form of LTP in the rodent cerebral cortex. (+info)

17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. (8/6275)

Gonadal steroid hormones influence CNS functioning through a variety of different mechanisms. To test the hypothesis that estrogen modulates synaptic plasticity in the hippocampus, in vitro hippocampal slices from 2-mo-old Sprague-Dawley male rats were used to determine the effect of 17beta-estradiol on both N-methyl-D-aspartate (NMDA) receptor-mediated excitatory postsynaptic potentials (EPSPs) through intracellular recordings and long-term potentiation (LTP) through extracellular recordings. Intracellular EPSPs and extracellular field EPSPs (fEPSPs) were recorded from CA1 pyramidal cells by stimulating Schaffer collateral fibers. In intracellular experiments, slices were perfused with medium containing bicuculline (5 microM) and low Mg2+ (0.1 mM) to enhance the NMDA receptor-mediated currents and 6, 7-dinitroquinoxaline-2,3-dione (DNQX) (10 microM) to block the alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprianate (AMPA) receptor-mediated component. The effects of 17beta-estradiol on NMDA receptor-mediated activity were excitatory; concentrations >10 nM induced seizure activity, and lower concentrations (1 nM) markedly increased the amplitude of NMDA-mediated EPSPs (both the first and second responses increased during paired pulse stimulation by 180 and 197%, respectively). In extracellular experiments, slices perfused with 17beta-estradiol (100 pM) exhibited a pronounced, persisting, and significant enhancement of LTP of both the fEPSP slope (192%) and fEPSP amplitude (177%) compared with control slices (fEPSP slope = 155%; fEPSP amplitude = 156%) 30 min after high-frequency stimulation. These data demonstrate that estrogen enhances NMDA receptor-mediated currents and promotes an enhancement of LTP magnitude. (+info)

Kleckner NW, Glazewski JC, Chen CC, Moscrip TD (May 1999). "Subtype-Selective Antagonism of N-Methyl-D-aspartate Receptors by ... Harty TP, Rogawski MA (March 2000). "Felbamate Block of Recombinant N-Methyl-D-aspartate Receptors: Selectivity for the NR2B ... Opposing Effects on N-Methyl-D-aspartate and Gamma-Aminobutyric Acid A Receptors". Annals of Neurology. 35 (2): 229-34. doi: ... "Felbamate Block of the N-Methyl-D-aspartate Receptor". The Journal of Pharmacology and Experimental Therapeutics. 273 (2): 878- ...

https://en.wikipedia.org/wiki/Felbamate

Schizophrenia: N-methyl-D-aspartate Receptor Dysfunction and Cortical Connectivity. 68 (1): 61-69. doi:10.1016/j.biopsych. ...

https://en.wikipedia.org/wiki/Resting_state_fMRI

December 2012). "N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis". Annals of Neurology. 72 (6): 902-911 ... November 2016). "N-methyl-d-aspartate receptor autoimmunity affects cognitive performance in herpes simplex encephalitis". ... Herpesviral encephalitis can serve as a trigger of anti-NMDA receptor encephalitis. About 30% of HSE patients develop this ... November 2019). "An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models". The ...

https://en.wikipedia.org/wiki/Herpesviral_encephalitis

N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes. Cline HT, Debski EA, Constantine-Paton M. Proc Natl ... Using this system, she and her colleagues demonstrated the importance of NMDA receptors in development plasticity. She ...

https://en.wikipedia.org/wiki/Martha_Constantine-Paton

Several receptors directly interact with ethanol to promote a cascade of signaling. N-methyl-D-aspartate (NMDA) receptors are ... Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors. Neurochem Int. 38, 333-340. Nagy, J. (2004). The NR2B ... Another family of receptors, metabotropic glutamate receptors (mGluR), may also contribute by activating MAPK pathways and ... In chronic ethanol users, ethanol binds to GABA receptors causing the down-regulation of GABA receptors; which are now less ...

https://en.wikipedia.org/wiki/Molecular_and_epigenetic_mechanisms_of_alcoholism

Lau LF, Huganir RL (1995). "Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits". J Biol Chem. 270 ... The major excitatory neurotransmitter receptors in the central nervous system are the glutamate receptors. These receptors can ... association of growth factor with receptor dimerization of receptor and autophosphorylation of receptor tyrosine kinase (RTK) ... Receptor tyrosine kinases are type I transmembrane proteins possessing an N-terminal extracellular domain, which can bind ...

https://en.wikipedia.org/wiki/Tyrosine_phosphorylation

1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors ... "Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B". Schröder HC, Perovic S, Kavsan V, et al. (1998 ... 1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a ... 1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes ...

https://en.wikipedia.org/wiki/GRIN3B

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in ... Activation of NMDA receptors requires binding of glutamate or aspartate (aspartate does not stimulate the receptors as strongly ... The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to ... Nadler V, Mechoulam R, Sokolovsky M (September 1993). "Blockade of 45Ca2+ influx through the N-methyl-D-aspartate receptor ion ...

https://en.wikipedia.org/wiki/NMDA_receptor

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved ... "Entrez Gene: GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D". Kurschner C, Yuzaki M (Sep 1999). "Neuronal ... Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline ... "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a ...

https://en.wikipedia.org/wiki/GRIN2D

"Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors". Neuron. 21 (2): 443-53. doi:10.1016/ ... "Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors". The ... "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature. 385 (6615): 439-42. doi:10.1038/385439a0. ... "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature. 385 (6615): 439-42. doi:10.1038/385439a0. ...

https://en.wikipedia.org/wiki/Alpha-actinin-2

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved ... "Entrez Gene: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C". Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity ... Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline ... "The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression". ...

https://en.wikipedia.org/wiki/GRIN2C

"A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in ... "Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia". Molecular Psychiatry. 18 (11): 1185-92. doi ... "Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and ... In particular, the expression of mRNA for the NR1 receptor subunit, as well as the protein itself is reduced in the prefrontal ...

https://en.wikipedia.org/wiki/Mechanisms_of_schizophrenia

"Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites". Organic Letters. 19 (17): 4572-4575. doi: ... support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists". Arch Gen Psychiatry. 57 (3): 270-6. doi: ... "Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors". Anesthesiology. 86 (4): 903-17. doi:10.1097/ ... of NMDA receptors in the brain results in an activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA ...

https://en.wikipedia.org/wiki/Ketamine

This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate- ... "Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A". Schröder HC, Perovic S, Kavsan V, Ushijima H, ... Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline ... "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a ...

https://en.wikipedia.org/wiki/GRIN3A

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor ... "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1". Sengar AS, Li H, Zhang W, Leung C, Ramani AK, Saw ... Pittaluga A, Pattarini R, Severi P, Raiteri M (May 1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline ... "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". ...

https://en.wikipedia.org/wiki/GRIN1

... hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors". J. Neurosci. 33 (44): 17290-300. doi: ... "Different oxysterols have opposing actions at N-methyl-D-aspartate receptors". Neuropharmacology. 85: 232-42. doi:10.1016/j. ... GABAA receptor positive allosteric modulator SGE-516 - GABAA receptor positive allosteric modulator SGE-872 - GABAA receptor ... GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, TRPM3 ...

https://en.wikipedia.org/wiki/List_of_neurosteroids

The underlying mechanism is autoimmune with the primary target the GluN1 subunit of the N-methyl D-aspartate receptors (NMDAR) ... Sébire, Guillaume (2010-02-23). "In search of lost time from "Demonic Possession" to anti-N-methyl-D-aspartate receptor ... "Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents". Annals of Neurology. 66 (1): 11-8. doi: ... "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Annals of Neurology. 61 (1): ...

https://en.wikipedia.org/wiki/Anti-NMDA_receptor_encephalitis

"Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A". Maruyama K, Sugano S (1994). "Oligo-capping ... NMDA receptor GRCh38: Ensembl release 89: ENSG00000255529 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000032199 - ... Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene ( ... Ionotropic glutamate receptors, All stub articles, Human chromosome 4 gene stubs). ...

https://en.wikipedia.org/wiki/GRINL1A

Sun S, Wallach J, Adejare A (2014). "Syntheses and N-methyl-D-aspartate receptor antagonist pharmacology of fluorinated ... and μ-opioid receptor agonistic properties. Additionally, σ receptor agonistic, nACh receptor antagonistic, and D2 receptor ... Structure activity relationship (SAR) studies of arylcycloalkylamines as N-methyl-D-aspartate receptor antagonists. PhD. Thesis ... For instance, 4-methyl-PCP, 4'-methyl-PCP and 4''-methyl-PCP are all known compounds, with similar activity but quite different ...

https://en.wikipedia.org/wiki/Arylcyclohexylamine

Mathiesen O, Imbimbo BP, Hilsted KL, Fabbri L, Dahl JB (August 2006). "CHF3381, a N-methyl-D-aspartate receptor antagonist and ... August 2003). "Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride ... a putative N-methyl-D-aspartate receptor antagonist". NeuroReport. 13 (16): 2071-4. doi:10.1097/00001756-200211150-00016. PMID ... non-competitive NMDA receptor antagonist. A pilot study of indantadol for chronic cough was initiated in October 2009 and in ...

https://en.wikipedia.org/wiki/Indantadol

January 2007). "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Annals of ... anti-NMDA receptor encephalitis, and polymyositis. The following diseases manifest by means of mucocutaneous dysfunction: ...

https://en.wikipedia.org/wiki/Paraneoplastic_syndrome

"Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker". Proceedings of the National Academy of ... Unlike other cannabinoid derivatives, HU-211 does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist ... NMDA receptor antagonists, Phenols, Benzochromenes, Primary alcohols, HU cannabinoids). ...

https://en.wikipedia.org/wiki/Dexanabinol

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown ... Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a ... "Entrez Gene: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B". Yoshimura Y, Ohmura T, Komatsu Y (July 2003). " ... Adams SL, Foldes RL, Kamboj RK (January 1995). "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and ...

https://en.wikipedia.org/wiki/GRIN2B

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved ... "Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A". Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, ... Ma J, Zhang GY (September 2003). "Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its ... Foldes RL, Adams SL, Fantaske RP, Kamboj RK (August 1994). "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: ...

https://en.wikipedia.org/wiki/GRIN2A

Brandt MR, Cummons TA, Potestio L, Sukoff SJ, Rosenzweig-Lipson S (June 2005). "Effects of the N-methyl-D-aspartate receptor ... August 2004). "Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0] ... a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere". ... NMDA receptor antagonists, Phosphonic acids, Quinones, Cyclobutenes, Nitrogen heterocycles, Heterocyclic compounds with 2 rings ...

https://en.wikipedia.org/wiki/Perzinfotel

Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex ... GABAA receptor positive allosteric modulators, NMDA receptor antagonists, Aromatic acids, Chloride channel blockers, All stub ... Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent ... positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". ...

https://en.wikipedia.org/wiki/Niflumic_acid

Woo TU, Shrestha K, Lamb D, Minns MM, Benes FM (April 2008). "N-Methyl-D-Aspartate Receptor and Calbindin-Containing Neurons in ... Suchanek B, Seeburg PH, Sprengel R (January 1995). "Gene structure of the murine N-methyl D-aspartate receptor subunit NR2C". J ... NMDA receptors rely on the EPSC produced by AMPA receptors to open. NMDA receptors are permeable to Ca2+, which is an important ... Johnson JW, Ascher P (May 1990). "Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels". ...

https://en.wikipedia.org/wiki/Glutamate_receptor

Chen BS, Braud S, Badger JD, Isaac JT, Roche KW (June 2006). "Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by ... The main receptors associated with PSD-95 are NMDA receptors. The first two PDZ domains of PSD-95 bind to the C-terminus of ... Glutamate receptor interacting protein (GRIP) is a post-synaptic protein that interacts with AMPA receptors in a fashion ... When researchers noticed apparent structural homology between the C-termini of AMPA receptors and NMDA receptors, they ...

https://en.wikipedia.org/wiki/PDZ_domain

Hirbec H, Gaviria M, Vignon J (2001). "Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor". ... With the use of this drug, motor skills have significantly improved upon use, as it is the antagonist to the NMDA receptor. ... is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor antagonist. It is ... "The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum". European Journal of ...

https://en.wikipedia.org/wiki/Gacyclidine

... a positive allosteric modulator at the N-methyl-D-aspartate receptor". Molecular Pharmacology. 40 (3): 333-6. PMID 1654510. ... CB1 receptor antagonists, Glycine receptor agonists, Ketones, Neurosteroids, Pregnane X receptor agonists, Pregnanes, Sigma ... December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature ... It prevents CB1 receptor agonists like tetrahydrocannabinol, the main active constituent in cannabis, from fully activating the ...

https://en.wikipedia.org/wiki/Pregnenolone

Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor ... "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult ... 2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): ... Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene. This gene encodes a protein ...

https://en.wikipedia.org/wiki/GRIK5

... showing the increased activity of N-methyl-D-aspartate receptors. This plays a role in consciousness and learning resulting in ... Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene. GABA is the major ... Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At ... Mu W, Cheng Q, Yang J, Burt DR (2002). "Alternative splicing of the GABA(A) receptor alpha 4 subunit creates a severely ...

https://en.wikipedia.org/wiki/GABRA4

"Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current". Mol. Pharmacol. 59 (5): 960 ... phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor ...

https://en.wikipedia.org/wiki/CAMK2B

... other receptors. For example, group I mGluRs are known to increase the activity of N-methyl-D-aspartate receptors (NMDARs), a ... "Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and ... the receptor most involved in that process. Excessive amounts of N-methyl-D-aspartate (NMDA), the selective specific agonist of ... "Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity". European Journal of ...

https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor

... also examined how mild exercise affected androgen synthesis which in turn causes AHN activation of N-methyl-D-aspartate (NMDA) ... Also, androgens, but not estrogens, increase beta adrenergic receptors while decreasing alpha adrenergic receptors- which ... Zuloaga DG, Puts DA, Jordan CL, Breedlove SM (May 2008). "The role of androgen receptors in the masculinization of brain and ... Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S (October 2004). "Androgen receptor in human skeletal muscle ...

https://en.wikipedia.org/wiki/Androgen

Postpartum anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review. Internal Medicine 56: 357-362 ... Ito Y, Abe T, Tomioka R, Komori T, Araki N (2010) [Anti-NMDA receptor encephalitis during pregnancy]. Rinsho Shinkeigaku 50: ... recent form of organic childbearing psychosis to be described is encephalitis associated with antibodies to the NMDA receptor; ... steroid hormone-dependent regulation of neuronal calcium influx via extracellular matrix proteins and membrane receptors ...

https://en.wikipedia.org/wiki/Postpartum_psychosis

... a positive allosteric modulator at the N-methyl-D-aspartate receptor" (abstract). Molecular Pharmacology. 40 (3): 333-6. PMID ... The GABAA receptors are made up of subunits which form a receptor complex. Humans have 19 receptor subunits and are classified ... Neurosteroids can act as allosteric modulators of neurotransmitter receptors, such as the GABAA, NMDA, and sigma receptors. The ... "Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

... danger and is likely caused by an overactivation of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4- ... The depolarization and calcium overload experienced by overactive receptors signal the expression of cell death pathways. ... isoxazolepropionic acid (AMPA) receptors by the surplus signaling of excitatory neurotransmitters. ...

https://en.wikipedia.org/wiki/Hippocampal_memory_encoding_and_retrieval

Glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B, also known as GRINL1B, is a human gene. The protein encoded by ... Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ (2001). "Assignment of GRINL1B, a glutamate receptor-like processed gene ... Ionotropic glutamate receptors, All stub articles, Membrane protein stubs). ... this gene is a subunit of the NMDA receptor. ...

https://en.wikipedia.org/wiki/GRINL1B

N-methyl-D-aspartate receptor - N-methylaspartate - N-terminus - NADH - NADPH - NaKATPase - native state - nef gene product - ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

Schäbitz WR, Li F, Fisher M (July 2000). "The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist". Journal of ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist". Journal of ...

https://en.wikipedia.org/wiki/Aptiganel

2014). "Immunotherapy for patients with acute psychosis and serum N-Methyl d-Aspartate receptor (NMDAR) antibodies: A ... "Prevalence of anti-N-methyl-d-aspartate (NMDA) receptor antibodies in patients with schizophrenia and related psychoses: A ... Estrogen seems to have a dampening effect on dopamine receptors. Evidence suggests that it is the interaction between genes and ... Silvestri S, Negrete JC, Seeman MV, Shammi CM, Seeman P (April 2004). "Does nicotine affect D2 receptor upregulation? A case- ...

https://en.wikipedia.org/wiki/Risk_factors_of_schizophrenia

However, brain-derived neurotrophic factor (BDNF) and the N-methyl-D-aspartate receptors (NMDA) have been identified as crucial ... DNA methylation is a process by which methyl groups attach to DNA structure causing the gene to not be expressed. This is ... and various DNA Methyl-Transferases (DNMTs), and increased presence of miRNAs for transcription factors and VEGF. It is ...

https://en.wikipedia.org/wiki/Epigenetic_therapy

Kim, Jeansok J.; Decola, Joseph P.; Landeira-Fernandez, Jesus; Fanselow, Michael S. (1991). "N-methyl-D-aspartate receptor ... Synthetic ligand injection - A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively ... These systems utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic small molecules ligands ... Ferguson, Susan (2012). "Grateful DREADDs: Engineered Receptors Reveal How Neural Circuits Regulate Behavior". ...

https://en.wikipedia.org/wiki/Behavioral_neuroscience

Xie, H Y; Clarke, S (1994). "Protein phosphatase-2A is reversibly modified by methyl esterification at its C-terminal leucine ... identifying membrane receptors for bacterial chemotaxis. Clarke's research at UCLA has focused on roles of novel protein ... D-aspartate) O-methyltransferase". J. Biol. Chem. 269 (40): 24586-24595. doi:10.1016/S0021-9258(17)31432-1. PMID 7929130. ...

https://en.wikipedia.org/wiki/Steven_Clarke

The synaptic changes depend on a special type of glutamate receptor, the N-methyl-D-aspartate (NMDA) receptor, a cell surface ... Drugs that interfere with NMDA receptors block LTP and have major effects on some types of memory, especially spatial memory. ... The hippocampus contains high levels of glucocorticoid receptors, which make it more vulnerable to long-term stress than most ... Furthermore, many other genes were upregulated, likely often due to the removal of methyl groups from previously existing 5- ...

https://en.wikipedia.org/wiki/Hippocampus

"Chronic intermittent ethanol treatment selectively alters N-methyl-D-aspartate receptor subunit surface expression in cultured ... Ethanol inhibits the ability of glutamate to open the cation channel associated with the N-methyl-D-aspartate (NMDA) subtype of ... Alteration of NMDA receptor numbers in chronic alcoholics is likely to be responsible for some of the symptoms seen in delirium ... NMDA receptors become unresponsive, slowing areas of the brain for which they are responsible. Contributing to this effect is ...

https://en.wikipedia.org/wiki/Short-term_effects_of_alcohol_consumption

"Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor anatagonist, AP5". ... The function of NMDA receptors varies according to the subregion of the hippocampus. NMDA receptors are required in the CA3 of ... Spatial learning requires both NMDA and AMPA receptors, consolidation requires NMDA receptors, and the retrieval of spatial ... Blockade of the NMDA receptors prevents induction of long-term potentiation and impairs spatial learning. The CA3 of the ...

https://en.wikipedia.org/wiki/Spatial_memory

"Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult ... This includes 5 subunits of the glutamate receptor ionotropic AMPA glutamate receptor subunits (Glur2, Glur3, Glur4) and ... "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor ... "Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain". The Journal ...

https://en.wikipedia.org/wiki/GRIA4

"Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist ... D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain. Since NMDA receptors Dysfunction has ... Serine racemase may have evolved from L-thre-hydroxyaspartate (L-THA) eliminase and served as the precursor to aspartate ...

https://en.wikipedia.org/wiki/Serine_racemase

Likewise, SP is known to bind to N-methyl-D-aspartate (NMDA) receptors by eliciting excitation with calcium ion influx, which ... The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein ... SP binds to all three of the tachykinin receptors, but it binds most strongly to the NK1 receptor. Tachykinin NK1 receptor ... NK1 receptor, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three ...

https://en.wikipedia.org/wiki/Tachykinin_receptor_1

... a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor, on the volume of ischemic brain damage off cytotoxic ... "Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors". Proceedings of the ... an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors". Experimental Neurology. 163 (1): 239-43. doi:10.1006/ ... a potent new neuroprotectant which blocks N-methyl-D-aspartate responses". Journal of Medicinal Chemistry. 38 (16): 3138-45. ...

https://en.wikipedia.org/wiki/Traxoprodil

... and N-methyl-D-aspartate). Inhibitory effects on 5-HT, norepinephrine, and dopamine transporters are weak. Lamotrigine is a ... It antagonises these receptors with the following IC50 values: 5-HT3, IC50 = 18 μM σ receptors, IC50 = 145 μM The ... It also blocks L-, N-, and P-type calcium channels and weakly inhibits the serotonin 5-HT3 receptor. These actions are thought ... Braga MF, Aroniadou-Anderjaska V, Post RM, Li H (March 2002). "Lamotrigine reduces spontaneous and evoked GABAA receptor- ...

https://en.wikipedia.org/wiki/Lamotrigine

One way they do this is by targeting the N-methyl-D-aspartate receptor (NMDAR), which has a vital role in transmission of ...

https://en.wikipedia.org/wiki/Joseph_T._Coyle

"Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor ... In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that ... Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, ... However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, ...

https://en.wikipedia.org/wiki/Sunifiram

Tikka TM, Koistinaho JE (June 2001). "Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by ... Over-excitation of glutamate receptors, specifically NMDA receptors, allows for an increase in calcium ion (Ca2+) influx due to ... 17β-Estradiol helps regulate excitotoxicity by inhibiting NMDA receptors as well as other glutamate receptors. Ginsenoside Rd: ... protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors ...

https://en.wikipedia.org/wiki/Neuroprotection

Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-D-aspartate receptors. Download Prime PubMed App ... polyamines at N-methyl-D-aspartate receptors.. *An aspartate residue in the extracellular loop of the N-methyl-D-aspartate ... AnimalsDose-Response Relationship, DrugN-MethylaspartatePeptide FragmentsReceptors, N-Methyl-D-AspartateRecombinant Proteins ... Williams K. Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-D-aspartate receptors. Mol Pharmacol ...

https://www.unboundmedicine.com/medline/citation/8058050/Mechanisms_influencing_stimulatory_effects_of_spermine_at_recombinant_N_methyl_D_aspartate_receptors_

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Message Subject (Your Name) has forwarded a page ...

https://molpharm.aspetjournals.org/content/50/6/1541/tab-e-letters

Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors ... Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors ... Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors ... Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors ...

https://jpet.aspetjournals.org/content/294/2/458.full

... receptor antibody encephalitis is becoming an increasingly recognized cause of encephalopathy in cases previously presumed to ... BACKGROUND: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is becoming an increasingly recognized cause of ... Three Phenotypes of Anti-N-Methyl-d-Aspartate Receptor Antibody Encephalitis in Children: Prevalence of Symptoms and Prognosis ... DeSena AD, Greenberg BM, Graves D (2014) Three Phenotypes of Anti-N-Methyl-d-Aspartate Receptor Antibody Encephalitis in ...

https://icnapedia.org/education/journal-watch/three-phenotypes-of-anti-n-methyl-d-aspartate-receptor-antibody-encephalitis-in-children-prevalence-of-symptoms-and-prognosis

An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough. Rayid Abdulqwai, Rachel ... Background: N-Methyl-D-Aspartate Receptor (NMDAR) mediated central sensitisation of the cough reflex may play a role in chronic ... An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough ... An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough ...

https://erj.ersjournals.com/content/44/Suppl_58/P949

Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics.. ... Circulating autoantibodies directed against extracellular domains of the glutamatergic N-methyl-D-aspartate receptors (NMDAR-Ab ... Since NMDAR and dopamine D1 receptors (D1R) form membrane signaling complexes, we investigated whether NMDAR-Ab purified from ...

https://research.pasteur.fr/en/publication/human-autoantibodies-against-n-methyl-d-aspartate-receptor-modestly-alter-dopamine-d1-receptor-surface-dynamics/

... untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. ... The N-methyl-D-aspartate (NMDA) receptor plays a central role in such phenomena as long term potentiation and excitotoxicity. ... The 5-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. Journal ... Whereas the NR1 subunit of the NMDA receptor is ubiquitously transcribed throughout the brain, transcription of NR2 subunits is ...

https://scholars.duke.edu/display/pub673551

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis. Patients with this ... Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis. Patients with this ... Anti-N-methyl-D-aspartate receptor encephalitis: characteristics and rapid diagnostic approach in the emergency department. * ... Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis, where pathogenic ...

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02752-9

N-methyl-D-aspartate receptors (NMDAR) are ionotropic glutamate receptors which can be blocked by Mg2+ in a voltage-dependent ... Methyl aspartate receptors, Alzheimers disease, NMDAR blocker, Neuroprotection. Subjects:. Q Science , QP Physiology , QP351 ... Abu, Izuddin Fahmy (2016) Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of ... Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of neurodegenerative disorders ...

http://eprints.nottingham.ac.uk/38591/

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease characterized by an antibody-mediated ... Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor.. Le 27 Oct 2021 ... Publications , Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor. ... Here, we immunized mice against the region of NMDA receptor containing the N368/G369 amino acids, previously implicated in a ...

https://www.bb-c.fr/publication/autoimmune-encephalitis-mediated-by-b-cell-response-against-n-methyl-d-aspartate-receptor/

Paroxysmal EEG pattern in a child with N-methyl-d-aspartate receptor antibody encephalitis ... Paroxysmal EEG pattern in a child with N-methyl-d-aspartate receptor antibody encephalitis ...

https://www.ndcn.ox.ac.uk/publications/243970

N-methyl-D-aspartate (NMDA) receptor: friend or foe? Indian Journal of Experimental Biology. 1998 Oct; 36(10): 947-59. ...

https://imsear.searo.who.int/handle/123456789/60354?mode=simple

N-Methyl-D-Aspartate" by people in this website by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor ... Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]. *Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200. ... Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]. *Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400. ... Receptors, Ionotropic Glutamate [D12.776.543.550.425.500.200]. *Receptors, N-Methyl-D-Aspartate [D12.776.543.550.425.500. ...

https://researchers.childrensmercy.org/display/18014

Chartoff, E. H., Ward, R. P., & Dorsa, D. M. (1999). Role of adenosine and N-methyl-D-aspartate receptors in mediating ... Chartoff, Elena H. ; Ward, Raymond P. ; Dorsa, Daniel M. / Role of adenosine and N-methyl-D-aspartate receptors in mediating ... Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. Journal of ... Dive into the research topics of Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene ...

https://ohsu.pure.elsevier.com/en/publications/role-of-adenosine-and-n-methyl-d-aspartate-receptors-in-mediating-2

N-methyl-D-aspartate (NMDA) receptor antagonists. * St. Johns wort (Hypericum perforatum) ... The HTR3A and HTR3B regions, which encode serotonin receptors and are located at chromosome 11q23.2, are also known to be ... Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet ... All this, together with preclinical research findings, implies a role for neuronal receptor regulation, intracellular signaling ...

https://www.medscape.com/answers/286759-14663/what-is-the-incidence-of-major-depressive-disorder-clinical-depression-in-adolescents-in-the-us

glutamate receptor subunit epsilon-2. *glutamate receptor, ionotropic, N-methyl D-aspartate 2B ... NMDA receptors are glutamate-gated ion channels. When brain chemicals called glutamate and glycine attach to the receptor, a ... A shortage of this protein may reduce the number of functional NMDA receptors, which would reduce receptor activity in cells. ... Researchers are unsure how abnormal activity of NMDA receptors prevents normal growth and development of the brain or why too ...

https://medlineplus.gov/genetics/gene/grin2b/

A key recent development was the discovery of antibodies to NMDA receptors in some cases of encephalitis, characterized by ... Here we describe a unique de novo autoimmune mouse model of anti-NMDA receptor encephalitis. Active immunization of immune ... competent mice with conformationally-stabilized, native-like NMDA receptors induced a fulminant encephalitis with behavioral ...

https://scholararchive.ohsu.edu/concern/etds/vh53ww25j?locale=en

... Published November 18, 2014 , By admin ... Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent ... N-methyl D-aspartate receptor antibodies, NMDA, research ...

http://www.dxiled.com/2014/11/18/link-human-n-methyl-d-aspartate-receptor-antibodies-alter-memory-and-behaviour-in-mice/

There are now a large number of requests for N-methyl-D-aspartate receptor autoantibody (NMDAR-Ab) tests, and it is important ... OBJECTIVE: There are now a large number of requests for N-methyl-D-aspartate receptor autoantibody (NMDAR-Ab) tests, and it is ... Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes. ... IMMUNOLOGY, NEUROIMMUNOLOGY, NMDA, PARANEOPLASTIC SYNDROME, PSYCHIATRY, Adolescent, Adult, Anti-N-Methyl-D-Aspartate Receptor ...

https://www.neuroscience.ox.ac.uk/publications/485389?9dcfda34-719b-11ed-a561-061ab7f93640

A series of short chain alkanols were studied for their effects on N-methyl-D-aspartate (NMDA)-evoked release [3H] ... Receptors, N-Methyl-D-Aspartate / drug effects * Receptors, N-Methyl-D-Aspartate / metabolism* ... Alcohol-induced inhibition of N-methyl-D-aspartate-evoked release of [3H]norepinephrine from brain is related to lipophilicity ... A series of short chain alkanols were studied for their effects on N-methyl-D-aspartate (NMDA)-evoked release [3H] ...

https://pubmed.ncbi.nlm.nih.gov/1830936/?dopt=Abstract

N-methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture. / Hwang, Jee Yeon; Kim, Yang Hee; Ahn, ... N-methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture. Experimental Neurology. 1999 Sep;159(1): ... N-methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture. In: Experimental Neurology. 1999 ; Vol. ... Hwang, J. Y., Kim, Y. H., Ahn, Y. H., Wie, M. B., & Koh, J. Y. (1999). N-methyl-D-aspartate receptor blockade induces neuronal ...

https://einstein.pure.elsevier.com/en/publications/n-methyl-d-aspartate-receptor-blockade-induces-neuronal-apoptosis-2

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus ... Dive into the research topics of N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation ...

https://waseda.pure.elsevier.com/en/publications/n-methyl-d-aspartate-receptors-are-indispensable-for-the-formatio/fingerprints/

N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in ... N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study ... N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in ... N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study ...

https://www.paediatrics.ox.ac.uk/publications/1192795

Anesthetic Care for a Pediatric Patient With Anti-N-Methyl-D-Aspartate Receptor Encephalitis ... First characterized in 2007, anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder with the ... Anesthetic Care for a Pediatric Patient With Anti-N-Methyl-D-Aspartate Receptor Encephalitis. ... We describe the anesthetic management of a patient with anti-NMDA receptor encephalitis who required anesthetic care during ...

https://www.journalmc.org/index.php/JMC/article/view/3310

... anesthetics nitrous oxide and xenon are reported to have little effect on GABAA receptors but inhibit N-methyl-d-aspartate ( ... NMDA receptors were the most sensitive among glutamate receptors and were inhibited by nitrous oxide by 31%. 5-HT3 receptors ... MethodsThe glycine, GABAA, GABA receptor type C (GABAC), NMDA, &agr;-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA ... The sensitivity was different between &agr;4&bgr;2 and &agr;4&bgr;4 nACh receptors; &agr;4&bgr;2 receptors were inhibited by ...

https://www.semanticscholar.org/paper/Effects-of-Gaseous-Anesthetics-Nitrous-Oxide-and-on-Yamakura-Harris/bf70f9e510731a36c8879a61564ee8eb8b6a5f24

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https://kgcuae.com/researchcenter/stress-korean-red-ginseng-reduces-chronic-social-defeat-stress-inducedmood-disorders-via-n-methyl-d-aspartate-receptor-modulation-inmice/

Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like ... group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was ... From: N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association ...

https://mecp.springeropen.com/articles/10.1186/s43045-021-00141-5/tables/4

Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2 −/− Mice ... Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2 −/− Mice In ... Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2 −/− Mice . ... Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2 −/− Mice ...

https://koreauniv.pure.elsevier.com/en/publications/early-correction-of-n-methyl-d-aspartate-receptor-function-improv

Stimulatory effects of spermine at heteromeric N-methyl-D-aspartate (NMDA) receptors expressed from cloned subunits were studied by voltage-clamp recording in Xenopus oocytes. (unboundmedicine.com)
At NR1A/NR2B receptors, in the presence of a saturating concentration of glycine, the magnitude of spermine stimulation was dependent on the concentration of NMDA or glutamate. (unboundmedicine.com)
Spermine induced a small (1.2-1.5-fold) decrease in the affinity of NR1A/NR2B receptors for NMDA and glutamate. (unboundmedicine.com)
Spermine did not alter the affinity of NR1A/NR2A receptors for NMDA. (unboundmedicine.com)
Endogenous polyamines could act as a bidirectional gain control at some native NMDA receptors containing the NR1A and NR2B subunits, by dampening the response to low concentrations of glutamate and enhancing the response to high concentrations of glutamate. (unboundmedicine.com)
Alternatively, polyamines could enhance the decay of NMDA receptor-mediated responses by increasing the rate of dissociation of glutamate from the receptor. (unboundmedicine.com)
A1 - Williams,K, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 161 EP - 8 JF - Molecular pharmacology JO - Mol Pharmacol VL - 46 IS - 1 N2 - Stimulatory effects of spermine at heteromeric N-methyl-D-aspartate (NMDA) receptors expressed from cloned subunits were studied by voltage-clamp recording in Xenopus oocytes. (unboundmedicine.com)
BACKGROUND: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is becoming an increasingly recognized cause of encephalopathy in cases previously presumed to be viral encephalitis. (icnapedia.org)
To find comparable articles reflecting this classification, we then performed a MEDLINE search of all articles involving the subject heading "anti-NMDA receptor encephalitis" or just the keyword phrase "NMDA encephalitis," and we found 162 articles to review. (icnapedia.org)
We note that the poorest responders, even to aggressive immunotherapies, are the patients with catatonia-persistent type anti-NMDA receptor antibody encephalitis, which has, as its hallmark, prolonged periods of severe encephalopathy. (icnapedia.org)
Patients with predominantly psychiatric symptoms, which we call the psychiatric-predominant anti-NMDA receptor antibody encephalitis, have had excellent responses to plasma exchange or other immunotherapies and appear to have the least residual deficits at follow-up. (icnapedia.org)
In our case series, we discuss representative examples of these clinical subtypes and their associated outcomes, and we suggest that tracking these subtypes in future cases of anti-NMDA receptor antibody encephalitis might lead to better understanding and better risk stratification with regard to immunotherapy decisions. (icnapedia.org)
The N-methyl-D-aspartate (NMDA) receptor plays a central role in such phenomena as long term potentiation and excitotoxicity. (duke.edu)
This importance in defining both function and viability suggests that neurons must carefully control their expression of NMDA receptors. (duke.edu)
Whereas the NR1 subunit of the NMDA receptor is ubiquitously transcribed throughout the brain, transcription of NR2 subunits is spatially and temporally controlled. (duke.edu)
Since heteromeric assembly of both subunits is required for efficient functional expression, post-transcriptional modification of either subunit would affect NMDA receptor activity. (duke.edu)
Taken together, these findings suggest a mechanism for modulation of NMDA receptor activity through the control of translational efficiency of a single subunit. (duke.edu)
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis, where pathogenic autoantibodies are directed against the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor. (biomedcentral.com)
NMDA receptors are found in the hippocampus of the human brain, where they are involved in learning and memory [ 1 ]. (biomedcentral.com)
Here, we immunized mice against the region of NMDA receptor containing the N368/G369 amino acids, previously implicated in a pathogenic response. (bb-c.fr)
IMSEAR at SEARO: N-methyl-D-aspartate (NMDA) receptor: friend or foe? (who.int)
NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. (childrensmercy.org)
Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). (childrensmercy.org)
We hypothesize that both striatal gene induction and catalepsy elicited by haloperidol arise from the combined effect of excitatory adenosinergic and glutamatergic inputs acting at adenosine A(2A) and N-methyl-D-aspartate (NMDA) receptors, respectively. (elsevier.com)
In agreement with other reports, the noncompetitive NMDA receptor antagonist MK-801 also reduced gene expression and catalepsy in response to haloperidol. (elsevier.com)
The competitive NMDA receptor antagonist LY235959 decreased haloperidol-induced catalepsy. (elsevier.com)
We show here that blocking both A(2A) and NMDA receptors simultaneously in conjunction with haloperidol resulted in a combined effect on gene expression and behavior that was greater than that for block of either receptor alone. (elsevier.com)
These results indicate that the haloperidol-induced increases in c-fos and NT gene expression in the dorsolateral striatum and catalepsy are driven largely by adenosine and glutamatergic inputs acting at A(2A) and NMDA receptors. (elsevier.com)
The GluN2B protein is one component (subunit) of a subset of specialized protein structures called NMDA receptors. (medlineplus.gov)
There are several types of NMDA receptors, made up of different combinations of proteins. (medlineplus.gov)
NMDA receptors are glutamate-gated ion channels. (medlineplus.gov)
NMDA receptors are involved in normal brain development, changes in the brain in response to experience (synaptic plasticity), learning, and memory. (medlineplus.gov)
A shortage of this protein may reduce the number of functional NMDA receptors, which would reduce receptor activity in cells. (medlineplus.gov)
some mutations reduce NMDA receptor signaling while others increase it. (medlineplus.gov)
Researchers are unsure how abnormal activity of NMDA receptors prevents normal growth and development of the brain or why too much or too little activity lead to similar neurological problems in people with GRIN2B -related neurodevelopmental disorder. (medlineplus.gov)
Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties. (medlineplus.gov)
A key recent development was the discovery of antibodies to NMDA receptors in some cases of encephalitis, characterized by cognitive changes, memory loss, seizures, and sometimes long-term morbidity or mortality. (ohsu.edu)
Here we describe a unique de novo autoimmune mouse model of anti-NMDA receptor encephalitis. (ohsu.edu)
Active immunization of immune competent mice with conformationally-stabilized, native-like NMDA receptors induced a fulminant encephalitis with behavioral and pathologic characteristics similar to those observed in the human disorder. (ohsu.edu)
Conantokin G, exclusive to piscivore cones, subdues prey by antagonizing the NMDA receptor, causing a sleeplike state. (medscape.com)
A series of short chain alkanols were studied for their effects on N-methyl-D-aspartate (NMDA)-evoked release [3H]norepinephrine (NE) from slices of cortex of the rat. (nih.gov)
The alkanols did not significantly depress the release of [3H]NE stimulated by 25 mM KCl, in the presence of 300 microM 2-amino-5-phosphonopentanoic acid (AP-5), suggesting that the alkanols have a selective effect at the NMDA receptor, as opposed to altering the release of neurotransmitter at the nerve terminal. (nih.gov)
It is concluded that the inhibitory effect of ethanol and related short chain alkanols on NMDA-stimulated release of [3H]NE involves an interaction with a lipophilic target, at or near the NMDA receptor-ionophore complex. (nih.gov)
Whereas excessive activation of the NMDA receptor may contribute to ischemic neuronal injury, physiologic activation may promote neuronal survival under certain conditions. (elsevier.com)
First characterized in 2007, anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder with the production of antibodies against the NMDA-type glutamate receptor. (journalmc.org)
We describe the anesthetic management of a patient with anti-NMDA receptor encephalitis who required anesthetic care during radiological imaging. (journalmc.org)
aminobutyric acid receptor type A (GABAA), the gaseous anesthetics nitrous oxide and xenon are reported to have little effect on GABAA receptors but inhibit N-methyl-d-aspartate (NMDA) receptors. (semanticscholar.org)
The discriminative stimulus effects of sub-anesthetic concentrations of isoflurane vapor appear to be mediated by both positive allosteric modulation of GABAA receptors as well as antagonism of NMDA receptors. (semanticscholar.org)
Previous studies revealed that antibodies reactive with NMDA (N-methyl-D-aspartate) receptor NR2 (anti-NR2) are elevated in cerebrospinal fluid (CSF) of patients with diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), which is usually more recalcitrant than neurologic syndromes of NPSLE (focal NPSLE). (altmetric.com)
Consistent with a prior report indicating that N -methyl- d -aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that d -2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 m m ethanol on staining. (jneurosci.org)
It is believed that certain opioids and their metabolites agonize the N -methyl-D-aspartate (NMDA) receptor. (uspharmacist.com)
Activation of the NMDA receptor causes an influx of calcium that greatly enhances the excitability of the neuron. (uspharmacist.com)
When the NMDA receptor and corresponding neurons are more active, they can more readily transmit painful impulses initiated by circulating substance P or other noxious stimuli. (uspharmacist.com)
Supporting this theory of pronociception modulated by NMDA receptor activation are studies showing relief of OIH after administration of NMDA receptor antagonists. (uspharmacist.com)
These antagonists noncompetitively bind to the phencyclidine site on the NMDA channel and block the influx of calcium that would occur when the receptor binds glutamate or another agonist. (uspharmacist.com)
10 Animal and human studies have demonstrated that subjects with OIH who were administered ketamine, an NMDA receptor antagonist, scored better during controlled pain-stimulus testing. (uspharmacist.com)
5 Other NMDA receptor antagonists, such as dextromethorphan, have demonstrated some evidence of relieving hyperalgesic states through inhibition at the NMDA receptor. (uspharmacist.com)
The human GCOM1 complex gene interacts with the NMDA receptor and internexin-alpha. (nih.gov)
Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist 11 . (nature.com)
One theory is that Alzheimer's disease may be caused, in part, by overactivation of N-methyl-D-aspartate (NMDA) receptors by the brain transmitter glutamate, which may add to the destruction of nerve cells. (worstpills.org)
Memantine is thought to work by blocking the NMDA receptors from binding to glutamate, thereby preventing cell death. (worstpills.org)
Herpesviral encephalitis can serve as a trigger of anti-NMDA receptor encephalitis . (wikipedia.org)
NMDA receptors (NMDARs) mediate ischemic brain damage, in part through interactions of the PDZ ligand of NR2 subunits with the PDZ domain proteins PSD-95 and neuronal nitric oxide synthase located within the NMDAR signaling complex. (hw.ac.uk)
1. Magnesium inhibits the NMDA receptors. (naturalnews.com)
NMDA receptors, which is short for N-methyl-D-aspartate, are crucial to the central nervous system. (naturalnews.com)
Magnesium helps manage these NMDA receptors , thus resulting in a better flow of thoughts and ideas. (naturalnews.com)
Furthermore, we discuss novel pharmacologic approaches, including the N-methyl-d-aspartate (NMDA) receptor ketamine and neuropeptide Y (NPY), as exciting new prospects for not only the treatment of PTSD but as new targets to enhance resilience. (cdc.gov)
The most commonly studied neuroprotective agents for acute stroke block the N -methyl-D-aspartate (NMDA) receptor. (medscape.com)
[ 6 ] A trial of another NMDA receptor antagonist, aptiganel HCl (Cerestat), was terminated because of concerns regarding benefit-to-risk ratios. (medscape.com)
5. The role of N-methyl-D-aspartate (NMDA) receptors in generating paroxysmal events was evaluated by application of 20 μM 2-amino- 5-phosphonovaleric acid, a specific blocker of this glutamate receptor type. (haifa.ac.il)
Blockage of NMDA receptors cut short the paroxysmal field potentials but did not prevent their generation. (haifa.ac.il)
Although activation of NMDA receptors does apparently contribute to the abnormal responsiveness, they are not essential for its existence in this kindling model. (haifa.ac.il)
Los receptores NMDA tienen un sitio de unión alostérico para la glicina que debe estar ocupado para que el canal se abra de manera eficiente y un sitio dentro del propio canal al cual se unen los iones magnesio en una forma que depende del voltaje. (bvsalud.org)
55 years on we're still finding out how it works, but one mode of action is as an NMDA receptor antagonist. (blogspot.com)
NMDA is N-Methyl-D-aspartate and a wholly artificial analogue of glutamate which is a natural neurotransmitter . (blogspot.com)
Esketamine and its parent compound ketamine work via the NMDA (N-methyl-D-aspartate) receptor in nerve cells. (psychedelicreview.com)
Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats. (cocites.com)
Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. (riajournal.com)
Here, we review the data that leptin influences hippocampal synaptic plasticity via enhancing NMDA (N-methyl-D-aspartate) receptor function. (ucc.ie)
We also provide evidence that rapid trafficking of NMDA receptors to the plasma membrane may underlie the effects of leptin on excitatory synaptic strength. (ucc.ie)
This treatment combination works by inhibiting N-Methyl-D-aspartate (NMDA) receptors, which increases the intracellular levels of glutamate, an excitatory neurotransmitter found throughout the central nervous system (CNS). (headinghealth.com)
In this review we look back at the progress made toward understanding the physiological and pathological role of NMDA receptor channels in mechanobiology of the nervous system and consider these findings in like of their potential functional implications for memory formation. (edu.au)
5,6 Encephalitis associated with anti- N -methyl- d Antibodies to the -aspartate (NMDA) receptor can lead to a neuropsychiatric presentation that often includes catatonic withdrawal and is associated with viral illnesses. (setup-mcafee.com)
7 The link between encephalitis associated with anti-NMDA receptor antibodies and SARS-CoV-2 has not yet been established, but a potential link has been suggested. (setup-mcafee.com)
To determine the immune mechanisms by which stress promotes the development of HSE, we examined the role of the glucocorticoid receptor (GR) and the N-methyl-d-aspartate (NMDA) receptor in the development of HSE. (umn.edu)
Our findings demonstrate that blockade of either the GR or the NMDA receptor enhances survival following HSV-1 infection in stressed mice to levels similar to non-stressed mice. (umn.edu)
Subsequent studies determined the effect of GR and NMDA receptor blockade on immune function by specifically examining both microglia and CD8 + T cell activation. (umn.edu)
Stress inhibited the expression of MHC class I by microglia and other brain-derived antigen presenting cells (CD45 hi ) independent of either the glucocorticoid receptor or the NMDA receptor, suggesting that stress-induced suppression of MHC class I expression in the brain does not affect survival during HSE. (umn.edu)
Blockade of the NMDA receptor, however, diminished HSV-1-induced increases in class I expression by CD45 hi cells, suggesting that blockade of the NMDA receptor may limit CNS inflammation. (umn.edu)
These findings indicate that stress-induced hypocellularity is mediated by the GR while NMDA receptor activation is responsible for enhancing CNS inflammation. (umn.edu)
The combined effects of GR-mediated hypocellularity of the SCLN and NMDA receptor-mediated CNS inflammation during stress promote the development of HSE. (umn.edu)
This NO 'tone' was sensitive to NOS substrate manipulation (200 μM l-arginine, 2 mM N G -nitro-l-arginine methyl ester) and Mg 2+ modulation of N-methyl-D-aspartate (NMDA) receptor conductance. (princeton.edu)
A drug called "memantine" which blocks the main GLU-excitotoxicity site in neurons - the NMDA GLU receptor (more on this later) - has been used clinically in Germany with significant success in treating Alzheimer's disease since 1991. (antiaging-nutrition.com)
12). Memantine's NMDA GLU-receptor blocking action has also shown promise in Parkinson's disease, diabetic neuropathic pain, glaucoma, HIV dementia, alcohol dementia, and vascular (stroke or arteriosclerosis - caused dementia (12). (antiaging-nutrition.com)
Experimental NMDA - GLU receptor blockers such as MK-801 (dizocilpine) have also demonstrated the ability to reduce or eliminate brain damage from acute conditions such as stroke, ischaemia/hypoxia/anoxia, severe hypoglycaemia, spinal cord injury and head trauma (1-3). (antiaging-nutrition.com)

DeSena AD, Greenberg BM, Graves D (2014) Three Phenotypes of Anti-N-Methyl-d-Aspartate Receptor Antibody Encephalitis in Children: Prevalence of Symptoms and Prognosis. (icnapedia.org)
Since NMDAR and dopamine D1 receptors (D1R) form membrane signaling complexes, we investigated whether NMDAR-Ab purified from patients with NMDAR-encephalitis or schizophrenia impaired D1R surface dynamics. (pasteur.fr)
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis. (biomedcentral.com)
Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor. (bb-c.fr)
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease characterized by an antibody-mediated autoimmune response against NMDAR. (bb-c.fr)
Anti- N -methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. (dxiled.com)

Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization. (nih.gov)
Low function of the N-methyl-D-Aspartate receptor (NMDAR) subtype glutamate receptor in the brain plays an important role in the pathophysiology of schizophrenia. (syneurxtrials.com)
In mammals, D-serine binds to an ion channel found in neurons called the N-methyl-D-aspartate type glutamate receptor (NMDAR) to regulate the transmission of messages in the brain. (lab-worldwide.com)

Patients' antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons a selective and reversible internalization of cell-surface receptors. (dxiled.com)
Many structures and processes are involved in the development of a seizure, including neurons, ion channels, receptors, glia, and inhibitory and excitatory synapses. (medscape.com)
Previous studies have shown that autoantibodies targeting cell surface proteins, such as the anti- N -methyl- d -aspartate receptor (anti-NMDAR), can directly disrupt the normal function of affected neurons ( 4 , 5 ). (snmjournals.org)
Excitotoxins are biochemical substances (usually amino acids, amino acid analogs, or amino acid derivatives) that can react with specialized neuronal receptors - GLU receptors - in the brain or spinal cord in such a way as to cause injury or death to a wide variety of neurons (1-3, 8-10). (antiaging-nutrition.com)

Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes. (ox.ac.uk)

N-methyl-D-aspartate receptors (NMDAR) are ionotropic glutamate receptors which can be blocked by Mg2+ in a voltage-dependent manner and are highly permeable to Ca2+, hence they represent a medically relevant target for neurodegenerative disorders caused by excitotoxicity. (nottingham.ac.uk)
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. (childrensmercy.org)
An increase in post-synaptic Ca2+ conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. (edu.au)

This effect was not related to the size of the macroscopic currents, the quantity or ratio of injected receptor subunit RNAs, or a voltage-dependent block by spermine. (unboundmedicine.com)
The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. (duke.edu)
GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. (nih.gov)
Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotorsubunit NR2C promotor. (mpg.de)

Acute blockade of dopamine D 2 receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. (elsevier.com)
Many of these agents modulate neuronal receptors to reduce release of excitatory neurotransmitters, which contribute to early neuronal injury. (medscape.com)
La dependencia positiva del voltaje de la conductancia del canal y la elevada permeabilidad del canal conductor a los iones calcio (así como a los cationes monovalentes) son importantes en la excitotoxicidad y en la plasticidad neuronal. (bvsalud.org)
We name neuronal receptors after the drug which was first shown to affect them. (blogspot.com)

Ischemia leads to excessive activation of excitatory amino acid receptors, accumulation of intracellular calcium, and release of other toxic products that cause cellular injury. (medscape.com)

Chartoff, EH, Ward, RP & Dorsa, DM 1999, ' Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy ', Journal of Pharmacology and Experimental Therapeutics , vol. 291, no. 2, pp. 531-537. (elsevier.com)

Glutamate is the primary endogenous agonist of the NDMA receptor. (uspharmacist.com)
Acupuncture also suppresses N -methyl-d-aspartate receptors (NMDAR) by inducing endogenous opioids in the intrarostral anterior cingulate cortex of the brain, which contributes to the inhibition of the affective dimension of pain [ 2 ]. (biomedcentral.com)
These receptors are essential in human beings physiologically, taking part in the rules of all of our physiological activities such as for example neurotransmission, enzyme launch, inflammation or chemotaxis, aswell as our feeling of vision, taste and smell, by sensing endogenous or environmental stimuli through binding suitable ligands and AZD-3965 IC50 transducing related sign into cells typically through combined heterotrimeric G proteins. (mdm2-inhibitors.com)

When enough receptors are simultaneously activated by NTs, the neuron will either "fire" an electric current all over its surface membrane, if the transmitter/receptors are excitatory, or else the neuron will be inhibited from electrically discharging, if the NT/receptors are inhibitory. (antiaging-nutrition.com)

A "motor cabal" causes paralysis by blocking neuromuscular transmission through inhibition of presynaptic voltage-gated calcium channels, postsynaptic nicotinic acetylcholine receptors, acetylcholine release, or skeletal muscle voltage-gated sodium channels. (medscape.com)

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. (aspetjournals.org)
Results suggest that inhibition of the (&agr;7)5 nACh receptor by N2O and Xe may play a role in their anesthetic effects. (semanticscholar.org)

Both halothane and isoflurane enhanced 5-HT3 receptor function in a concentration-dependent manner, which is consistent with previous studies and suggests the inhibitory mechanism of sevoflURane might be different from those of N2O and Xe. (semanticscholar.org)
It binds specifically to GABA A receptors to enhance their inhibitory effects. (medscape.com)

Circulating autoantibodies directed against extracellular domains of the glutamatergic N-methyl-D-aspartate receptors (NMDAR-Ab) elicit psychotic symptoms in humans and behavioral deficits in animal models. (pasteur.fr)

The study will investigate the efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used for burst suppression that target the gamma-aminobutyric acid adrenergic receptors. (clinicaltrials.gov)
Ketamine, an intravenous anesthetic agent which is a non-competitive antagonist of N-methyl-D-aspartate receptors can block the flow of Ca and Na and by combining with phencyclidine binding sites inside the ion channel of N-methyl-D-aspartate receptors, reduce the epileptiform burst discharges and after potential. (clinicaltrials.gov)
First, the induction and expression of the rhythms were not blocked by the N-methyl-d-aspartate receptor antagonist d-2-amino-5-phosphonovaleric acid, indicating that a long-term potentiation effect between pyramidal cells was not involved. (escholarship.org)
Technically, the anesthetic ketamine is not a hallucinogen because it is an antagonist of the serotonin 5-HT 2A receptor. (psychedelicreview.com)

The intensity of the paroxysmal response was greatly enhanced by application of γ- aminobutyric acid-A (GABAa) receptor blockers to the bath. (haifa.ac.il)

Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics. (pasteur.fr)

Muscarinic acetylcholine receptors, vital components of the parasympathetic nervous system, were discovered by injecting muscarine which is produced by certain mushrooms . (blogspot.com)

When brain chemicals called glutamate and glycine attach to the receptor, a channel opens, allowing positively charged particles (cations) to flow through. (medlineplus.gov)
This paper is about a very different glycine receptor, the homomeric alpha2 receptor. (ucl.ac.uk)
In this paper we find, for both glycine and nicotinic receptors, that opening and shutting of the channel is very much the same for partial and full agonists. (ucl.ac.uk)
Andrew J.R. Plested, Paul J Groot-Kormelink, David Colquhoun, and Lucia G Sivilotti (2007) Single channel study of the spasmodic mutation {alpha}1A52S in recombinant rat glycine receptors. (ucl.ac.uk)
A study of the spasmodic mutation in the glycine receptor. (ucl.ac.uk)
When interpreted in terms of the 'flip' mechanism , the results suggest that the impairment of the receptor function results largely from a large reduction in the affinity of glycine for the flipped conformation, i.e. a shut conformation of the receptor that can be adopted once the ligand is bound, but precedes the opening of the channel. (ucl.ac.uk)

Methadone is a synthetic opioid and full agonist at the μ-opioid receptor and induces other opioid receptors. (statpearls.com)

These potent peptides, which fold into small, highly structured frameworks, largely target ion channels, either voltage- or ligand-gated receptors and transporters in excitable cells. (medscape.com)
Predicated on series homology, ligand framework or receptor function, GPCRs are categorized into several hundred subfamilies. (mdm2-inhibitors.com)

N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. (ox.ac.uk)
Shank2 −/− mice, known to display N-methyl-D-aspartate receptor (NMDAR) hypofunction and autistic-like behaviors at postweaning stages after postnatal day 21 (P21), show the opposite synaptic phenotype-NMDAR hyperfunction-at an earlier preweaning stage (∼P14). (elsevier.com)

Therefore, targeting the N-methyl-D-aspartate receptors with ketamine may provide a novel approach to control refractory seizures. (clinicaltrials.gov)
Moreover, by blocking glutamate mediated N-methyl-D-aspartate receptor induced neurotoxicity, ketamine may render neuroprotection. (clinicaltrials.gov)

Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. (cocites.com)

Opioid receptors for example: we don't make opium or its derivatives in our brains but we do have receptors that are responsive to these alien chemicals. (blogspot.com)
The μ-opioid receptors, located in the CNS (e.g., brainstem, locus coeruleus, periaqueductal gray matter) and parts of the gastrointestinal tract, act to modulate various neurochemical activities involved in analgesia, euphoria, and sedation. (statpearls.com)

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. (cdc.gov)

An entire subset of antibody-positive patients, anti- N -methyl- d -aspartate receptor (5 patients), had normal MRI results and abnormal 18 F-FDG PET/CT findings whereas the other subsets demonstrated a greater heterogeneity. (snmjournals.org)

2. Magnesium binds with GABA receptors. (naturalnews.com)
Magnesium binds with gamma-aminobutyric acid (GABA) receptors. (naturalnews.com)

Remigijus Lape, Paraskevi Krashia, David Colquhoun and Lucia G. Sivilotti (2009)) Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors. (ucl.ac.uk)

In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. (ucc.ie)

Introduction G-protein combined receptors (GPCRs), known as seven-transmembrane (7TM) site receptors also, although diverse functionally, constitute the biggest integral membrane proteins family members in the human being genome [1]C[3]. (mdm2-inhibitors.com)

AMPA receptors, when assayed in heterologous expression systems, showed a sensitivity to inhalational anesthetics that was minimal when glutamate was applied rapidly at high concentrations, which concludes that AMPA receptors are unlikely to play a major role in the production of the anesthetic state by inhalational agents. (semanticscholar.org)

This is attributed to decrease in activity of gamma-aminobutyric acid receptors along with reciprocal up regulation of N-Methyl-D-aspartate receptors. (clinicaltrials.gov)

Glutamate activation of N-methyl-D-aspartate receptors promotes calcium influx and excitotoxicity. (clinicaltrials.gov)

The GABA receptors are the neurotransmitters responsible for calming nerve activity. (naturalnews.com)

These activate insulin receptors in prey, mimicking the effects of insulin and causing prey "insulin shock" with disorientation. (medscape.com)
For the present study, a terpenoid constituent from G. biloba , bilobalide, was screened for protective effects on the ischaemic heart and the involvement of the PAFR [PAF (platelet-activating factor) receptor] and the enzyme that degrades PAF, PAF-AH (PAF acetylhydrolase) during hypoxia. (portlandpress.com)
Our results indicate that PAF and its receptor may be involved in the cellular response of cardiomyocytes to hypoxia and that bilobalide may interact with this receptor to exert its cardioprotective effects. (portlandpress.com)

Anatomy1

Organisms1

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes7

Information Science2

Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine. (1/6275)

Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (2/6275)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/6275)

Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors. (4/6275)

Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. (5/6275)

Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance. (6/6275)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. (7/6275)

17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. (8/6275)

Complement C5a

Aspartate Aminotransferases

Aspartate Carbamoyltransferase

Aspartic Acid

Aspartate Kinase

Alanine Transaminase

Aspartate Ammonia-Lyase

NG-Nitroarginine Methyl Ester

Receptors, Amino Acid

Methyl Parathion

Glutamates

Aspartate Aminotransferase, Mitochondrial

Kinetics

Phosphonoacetic Acid

Escherichia coli

Carbamyl Phosphate

Methyl Methanesulfonate

Dihydroorotase

Glutamic Acid

Molecular Sequence Data

Amino Acids

Amino Acid Sequence

Cytidine Triphosphate

Methyl Chloride

Pyridoxal Phosphate

Liver

Homoserine Dehydrogenase

Glutamine

Aminooxyacetic Acid

Binding Sites

Transaminases

Magnetic Resonance Spectroscopy

Succinates

Methylation

Aspartate-Semialdehyde Dehydrogenase

Models, Molecular

Mutagenesis, Site-Directed

Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)

Alanine

Pyridoxamine

Protein Conformation

Ketoglutaric Acids

Oxaloacetates

Malates

Structure-Activity Relationship

Catalysis

Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine. (1/6275)

Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (2/6275)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/6275)

Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors. (4/6275)

Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. (5/6275)

Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance. (6/6275)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. (7/6275)

17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. (8/6275)

Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices

Expressions of N-methyl-D-aspartate receptors NR2A and NR2B su...

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. - Université de...

Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase

Pharmacology of ACEA-1416: A potent systemically active NMDA receptor glycine site antagonist<...

Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs

Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors: With an appendix: Diffusion of transported...

Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit. | Molecular...

Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-D-aspartate receptor...

Glutamate (NMDA) Receptors | Targeting FAK in human cancer

Nazarbayev University Repository

N-methyl-d-aspartate receptor antagonists enhance the head-twitch response, a 5-hydroxytryptamine(2) receptor-mediated...

Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal...

Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS | Journal...

HKU Scholars Hub: Small Interfering RNA Specific for N-Methyl-D-Aspartate Receptor 2B Offers Neuroprotection to Dopamine...

Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and...

Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation. -...

Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation. - Wellcome...

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in...

Plus it

Anti-GluN2B/NR2B Glutamate Receptor Antibody

QNZ46 | CAS#1237744-13-6 | NMDA receptor antagonist | MedKoo

Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3-Kinase Cascades to Up-regulate the N-Methyl-D-aspartate Receptor 1...

Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids - Full Text View - ClinicalTrials.gov

Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids - Full Text View - ClinicalTrials.gov

Abstract TMP30: Activation of Neuronal NMDA Receptors After Ischemia as Signal to Trigger Neuronal Il-4 Production Role in...