An intermediate in the biosynthesis of cerebrosides. It is formed by reaction of sphingosine with UDP-galactose and then itself reacts with fatty acid-Coenzyme A to form the cerebroside.
An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
A subfamily of lysophospholipid receptors with specificity for LYSOSPHINGOLIPIDS such as sphingosine-1-phosphate and sphingosine phosphorylcholine.

Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. (1/583)

Murine CD4 and CD8 T cells express predominantly types 1 and 4 sphingosine 1-phosphate (S1P) G protein-coupled receptors (designated S1P1 and S1P4 or previously endothelial differentiation gene-encoded 1 and 6) for S1P, which has a normal plasma concentration of 0.1-1 microM. S1P now is shown to enhance chemotaxis of CD4 T cells to CCL-21 and CCL-5 by up to 2.5-fold at 10 nM to 0.1 microM, whereas 0.3-3 microM S1P inhibits this chemotaxis by up to 70%. Chemotaxis of S1P(1), but not S1P(4), transfectants to CXCL1 and CXCL4 was similarly affected by S1P. Activation of CD4 T cells, which decreases S1P receptor expression, suppressed effects of S1P on chemotaxis. Pretreatment of labeled CD4 T cells with S1P before reintroduction into mice inhibited by a maximum of 75% their migration into chemokine-challenged s.c. air pouches. The S1P-S1P(1) receptor axis thus controls recruitment of naive T cells by maintaining their response threshold to diverse lymphotactic factors.  (+info)

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. (2/583)

We investigated mechanisms for inhibition of B16 melanoma cell migration and invasion by sphingosine-1-phosphate (S1P), which is the ligand for the Edg family G protein-coupled receptors and also implicated as an intracellular second messenger. S1P, dihydro-S1P, and sphingosylphosphorylcholine inhibited B16 cell migration and invasion with the relative potencies expected as S1P2 receptor agonists. The S1P2-selective antagonist JTE013 completely abolished the responses to these agonists. In addition, JTE013 abrogated the inhibition by sphingosine, which is the S1P precursor but not an agonist for S1P receptors, indicating that the sphingosine effects were mediated via S1P2 stimulation, most likely by S1P that was converted from sphingosine. S1P induced inhibition and activation, respectively, of Rac and RhoA in B16 cells, which were abrogated by JTE013. Adenovirus-mediated expression of N17Rac mimicked S1P inhibition of migration, whereas C3 toxin pretreatment, but not Rho kinase inhibitors, reversed the S1P inhibition. Overexpression of S1P2 sensitized, and that of either S1P1 or S1P3 desensitized, B16 cells to S1P inhibition of Rac and migration. In JTE013-pretreated, S1P3-overexpressing B16 cells, S1P stimulated cellular RhoA but failed to inhibit either Rac or migration, indicating that RhoA stimulation itself is not sufficient for inhibition of migration. These results provide compelling evidence that endogenously expressed S1P2 negatively regulates cell motility and invasion through ligand-dependent reciprocal regulation of cellular Rac and RhoA activities. In the presence of JTE013, S1P instead stimulated Rac and migration in B16 cells that overexpress either S1P1 or S1P3, unveiling counteractions between S1P2 and S1P1 or S1P3 chemotactic receptor.  (+info)

Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. (3/583)

Lifetime exposure to estrogens is a major risk factor in breast cancer, but the mechanism for this action is not fully defined. To better determine this mechanism, the activation domain of estrogen receptor (ER) alpha was used in yeast two-hybrid screenings. These screenings resulted in the identification of a novel antiproliferative protein, estrogen down-regulated gene 1 (EDG1), of which the mRNA and protein were shown to be down-regulated directly by estrogens. Our studies additionally suggested an important role for EDG1 in ER alpha-mediated breast cancer development. Analysis of 43 invasive breast cancer samples and 40 adjacent normal breast samples demonstrated EDG1 protein levels to be significantly higher in normal breast epithelial tissue as compared with breast epithelial tumor tissue. EDG1 expression levels were also correlated with the proliferation activity and ER alpha status of the tumors to examine the prognostic value of EDG1 in invasive breast tumors. EDG1 expression was more disassociated from proliferative activity as compared with ER alpha expression in tumor cells. A growth regulatory function for EDG1 is additionally indicated by studies wherein overexpression of EDG1 protein in breast cells resulted in decreased cell proliferation and decreased anchorage-independent growth. Conversely, inhibiting EDG1 expression in breast cells resulted in increased breast cell growth. Thus, we have identified a novel growth inhibitor that is down-regulated by estrogens and colocalizes with ER alpha in breast tissue. These studies support a role for EDG1 in breast cancer.  (+info)

Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. (4/583)

The endothelial cell-expressed sphingosine 1-phosphate receptors Edg-1/S1P1 and Edg-3/S1P3 have been implicated in various physiological events such as the regulation of angiogenesis. Since there is an excess of a ligand constitutively in blood, these receptors may have some mechanism(s) avoiding overstimulation. In this study, we found that the N-terminal ectodomains of Edg-1/S1P1 and Edg-3/S1P3 were truncated in overexpressing cells. The truncated form of Edg-1/S1P1 expressed on the cell surface had undergone complex-type oligosaccharide modification at the Golgi. A deletion mutant lacking the N-terminal processing domain of Edg-1/S1P1 accumulated in the endoplasmic reticulum, and was not expressed on the cell surface. When a basic amino acid residue was introduced at the cleavage site of Edg-1/S1P1, the molecular weight of the glycosylated protein was greater in the mutant compared to the wild type, due to the bound oligosaccharide. These results demonstrated that the structure of the N-terminal ectodomain of Edg-1/S1P1 affects both its transport to the cell surface and the N-glycosylation process. Ectodomain shedding of many membrane proteins has been implicated in various diseases. Therefore, N-terminal processing of Edg-1/S1P1 and Edg-3/S1P3 might play roles in endothelial cell functions.  (+info)

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. (5/583)

The novel immunomodulator FTY720 is effective in experimental models of transplantation and autoimmunity, and is currently undergoing Phase III clinical trials for prevention of kidney graft rejection. In contrast to conventional immunosuppressants, FTY720 does not impair T- and B-cell activation, proliferation and effector function, but interferes with cell traffic between lymphoid organs and blood. The molecular basis for the mode of action of the drug has only recently been established. FTY720, after phosphorylation, acts as a high-affinity agonist at the G protein-coupled sphingosine 1-phosphate receptor-1 (S1P(1)) on thymocytes and lymphocytes, thereby inducing aberrant internalization of the receptor. This renders the cells unresponsive to the serum lipid sphingosine 1-phosphate (S1P), depriving them from an obligatory signal to egress from lymphoid organs. As a consequence, lymphocytes are unable to recirculate to peripheral inflammatory tissues and graft sites but remain functional in the lymphoid compartment. In addition to the effects on lymphocyte recirculation, the drug acts on endothelial cells and preserves vascular integrity by enhancing adherens junction assembly and endothelial barrier function. The available data establish S1P(1) as a key target for FTY720, and further point to therapeutically relevant effects of the drug on lymphocytes and vascular endothelium.  (+info)

Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate. (6/583)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that affects a variety of cellular processes through both its actions as a second messenger and via activation of a family of G protein-coupled receptors (S1P(1-5)). The study of S1P receptor pharmacology, particularly S1P(4), has been hindered by the lack of high-affinity radioligands with good specific activity. The studies presented herein characterize [(3)H]DH-S1P as a stable, high-affinity radioligand for S1P(4) pharmacology. Using a transfected Ba/F3 cell line selected for high hS1P(4) surface expression, we compared the consequences of different cellular backgrounds and commercial sources of sphingophospholipids on S1P(4) characterization. The development and subsequent use of the assay described has enabled us to extensively and definitively characterize the pharmacology of the human S1P(4) receptor.  (+info)

The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. (7/583)

Accumulation of inflammatory mononuclear phagocytes in Alzheimer's senile plaques, a hallmark of the innate immune response to beta-amyloid fibrils, can initiate and propagate neurodegeneration characteristic of Alzheimer's disease. Phagocytes migrate toward amyloid beta-protein involving formyl peptide receptor like-1-dependent signaling. Using human peripheral blood monocytes in Boyden chamber micropore filter assays, we show that the amyloid beta-protein- and amyloid beta-precursor protein-induced migration was abrogated by dimethylsphingosine, a sphingosine kinase inhibitor. Amyloid beta-protein stimulated in monocytes the gene expression for sphingosine-1-phosphate receptors 2 and 5, but not 1, 3, and 4. FTY720 that acts as a sphingosine-1-phosphate receptor agonist after endogenous phosphorylation by sphingosine kinase, as well as various neuropeptides that are known to be monocyte chemoattractants, dose-dependently inhibited amyloid beta-protein-induced migration. These data demonstrate that the migratory effects of beta-amyloid in human monocytes involve spingosine-1-phosphate signaling. Whereas endogenous neuropeptides may arrest and activate monocytes at sites of high beta-amyloid concentrations, interference with the amyloid beta-protein-dependent sphingosine-1-phosphate pathway in monocytes by FTY720, a novel immunomodulatory drug, suggests that FTY720 may be efficacious in beta-amyloid-related inflammatory diseases.  (+info)

Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells. (8/583)

To analyze the involvement in allergic reactions of platelets and sphingosine 1-phosphate (Sph-1-P), a lysophospholipid mediator released from activated platelets, the effects of Sph-1-P and a supernatant prepared from activated platelets on mast cell line RBL-2H3 were examined. Sph-1-P strongly inhibited the migration of both non-stimulated and fibronectin-stimulated RBL-2H3 cells, which was reversed by JTE-013, a specific antagonist of G protein-coupled Sph-1-P receptor S1P(2); S1P(2) was confirmed to be expressed in these cells. A similar anti-motility effect of Sph-1-P was observed in a phagokinetic assay. Consistent with these results, treatment of RBL-2H3 cells with Sph-1-P resulted in a rounded cell morphology, which was blocked by JTE-013. Under the present conditions, Sph-1-P failed to induce intracellular Ca(2+) mobilization or histamine degranulation, responses postulated to be elicited by intracellular Sph-1-P. Importantly, the Sph-1-P effect, i.e., the regulation of RBL-2H3 cell motility, was mimicked by the supernatant (both with and without boiling) prepared from activated platelets, and this effect of the supernatant was also blocked by JTE-013. Our results suggest that the motility of mast cells can be regulated by Sph-1-P and also platelets (which release Sph-1-P), via cell surface receptor S1P(2) (not through intracellular Sph-1-P actions, postulated previously in the same cells).  (+info)

I'm sorry for any confusion, but "psychosine" is not a commonly used term in medicine or psychology. It is a lipid molecule that has been researched in the context of certain neurological conditions, particularly Krabbe disease, which is a rare and fatal genetic disorder affecting the nervous system.

In Krabbe disease, psychosine accumulates in the body due to a deficiency of an enzyme called galactocerebrosidase. This buildup of psychosine is thought to contribute to the damage and destruction of nerve cells, leading to the symptoms of the disease. However, it's important to note that this is still an area of ongoing research, and there is no medical definition for "psychosine" in a general sense.

Sphingosine is not a medical term per se, but rather a biological compound with importance in the field of medicine. It is a type of sphingolipid, a class of lipids that are crucial components of cell membranes. Sphingosine itself is a secondary alcohol with an amino group and two long-chain hydrocarbons.

Medically, sphingosine is significant due to its role as a precursor in the synthesis of other sphingolipids, such as ceramides, sphingomyelins, and gangliosides, which are involved in various cellular processes like signal transduction, cell growth, differentiation, and apoptosis (programmed cell death).

Moreover, sphingosine-1-phosphate (S1P), a derivative of sphingosine, is an important bioactive lipid mediator that regulates various physiological functions, including immune response, vascular maturation, and neuronal development. Dysregulation of S1P signaling has been implicated in several diseases, such as cancer, inflammation, and cardiovascular disorders.

In summary, sphingosine is a crucial biological compound with medical relevance due to its role as a precursor for various sphingolipids involved in cellular processes and as a precursor for the bioactive lipid mediator S1P.

Lysosphingolipid receptors are a type of cell surface receptor that bind to lysosphingolipids, which are bioactive lipids derived from the degradation of sphingolipids. Sphingolipids are a class of lipids that play important roles in cell signaling and membrane structure.

Lysosphingolipids, such as lysosulfatide, lyso-Gb1 (lysoganglioside GM1), and lyso-PS (lysophosphatidylserine), have been implicated in various physiological and pathological processes, including cell proliferation, differentiation, inflammation, and apoptosis.

Lysosphingolipid receptors include several proteins, such as P2X7 receptor, G2A receptor, and Mas-related G protein-coupled receptor member X2 (MRGX2), that have been identified to interact with lysosphingolipids and mediate their downstream signaling.

Abnormal accumulation of lysosphingolipids has been associated with several diseases, including lysosomal storage disorders, neurodegenerative disorders, and cancer. Therefore, understanding the biology of lysosphingolipid receptors may provide insights into the development of new therapeutic strategies for these diseases.

It is now known that sphingosine-1-phosphate receptors (S1P receptors) are members of the lysophospholipid receptor family. ... Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a ... There are 5 types of Sphingosine-1-phosphate receptor. The drug fingolimod (FTY720), which agonizes the S1P receptor, prevents ... possibly through the S1P1 receptor. The S1P receptor agonist etrasimod has been shown to induce remission in patient with ...
... receptors, lysosphingolipid MeSH D12.776.543.750.100.430.500 - receptor, melanocortin, type 1 MeSH D12.776.543.750.100.430.750 ... receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb-3 MeSH D12.776.543.750.060.468 - receptor, igf type 1 MeSH ... receptor, igf type 1 MeSH D12.776.543.750.750.400.780.410 - receptor, igf type 2 MeSH D12.776.543.750.750.400.820 - receptors, ... receptor, trkb MeSH D12.776.543.750.060.499 - receptor, trkc MeSH D12.776.543.750.060.500 - receptors, eph family MeSH D12.776. ...
This is a "connection" page, showing publications Beichu Guo has written about Receptors, Lysosphingolipid. ...
Lysophospholipid Family S1P5 receptor. View product information for catalog number - C1054-1. Downloadable pdf data sheet ... Background: The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite ... S1P and the structurally related LPA signal cells through a set of G-protein-coupled receptors known as EDG receptors. S1P5 or ... 2000) Characterization of a novel phingosine 1-phosphate receptor, Edg-8. J Biol Chem 275:14281-14286. ...
Cycles of G-protein-coupled receptor kinase-2 (GRK2) mediated S1PR1 desensitization and resensitization underlie this ... Sphingosine-1-phosphate (S1P) and S1P-receptor-1 (S1PR1) promote lymphocyte egress from white to red pulp and back to ... Sphingosine-1-phosphate (S1P) and S1P-receptor-1 (S1PR1) promote lymphocyte egress from white to red pulp and back to ... Cycles of G-protein-coupled receptor kinase-2 (GRK2) mediated S1PR1 desensitization and resensitization underlie this ...
Receptors, Lysosphingolipid. dc.subject.otherChemCAS. Recombinant Fusion Proteins. dc.subject.otherChemCAS. S1PR1 protein, ... we found that LDL induced S1P receptor activation. Pretreating cells with S1P1-S1P3 receptor antagonist VPC23019 significantly ... Our data suggest that SK1- dependent S1P receptor transactivation is upstream of ERK1-2 and JNK and that all three steps are ... Using a green fluorescent protein-tagged S1P1 receptor as a biological sensor for the generation of physiologically relevant ...
Receptors, Lysosphingolipid (2004-2019). Public MeSH Note:. 2020. History Note:. 2020. DeCS ID:. 59246 ... Agents that affect the function of G-protein coupled SPHINGOSINE 1-PHOSPHATE RECEPTORS. Their binding to the receptors blocks ... Agents that affect the function of G-protein coupled SPHINGOSINE 1-PHOSPHATE RECEPTORS. Their binding to the receptors blocks ... Sphingosine 1 Phosphate Receptor Modulators Descriptor Spanish: Moduladores de los Receptores de fosfatos y esfingosina 1 ...
Receptors, Lysosphingolipid. _. Top Journals Top journals in which articles about this concept have been published. ... "Receptors, G-Protein-Coupled" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat Chem Biol. 2023 08; 19(8):1013-1021. ... The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through ...
Contrary to CADs, lysosphingolipid-induced cell death was independent of lysosomal Ca2+ efflux through P2X purinerigic receptor ... nicotinic and muscarinic receptor agonists, and trace amine-associated receptor-1 agonists, offer promise toward relevant ... Exposure to dopamine receptor blocking agents (DRBAs) such as antipsychotics or antiemetics is associated with a spectrum of ... OBJECTIVE: A combination of olanzapine and the opioid receptor antagonist samidorphan (OLZ/SAM) has been approved in the United ...
It is now known that sphingosine-1-phosphate receptors (S1P receptors) are members of the lysophospholipid receptor family. ... Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a ... There are 5 types of Sphingosine-1-phosphate receptor. The drug fingolimod (FTY720), which agonizes the S1P receptor, prevents ... possibly through the S1P1 receptor. The S1P receptor agonist etrasimod has been shown to induce remission in patient with ...
Lymphotoxin beta Receptor, Lysosphingolipid, Mammalian, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, NF-kappa B, ... Lymphotoxin beta Receptor, Lysosphingolipid, Mammalian, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, NF-kappa B, ... Organogenesis, Receptor Activator of Nuclear Factor-kappa B, Receptors, Signal Transduction, Team-Mueller, transgenic ... Organogenesis, Receptor Activator of Nuclear Factor-kappa B, Receptors, Signal Transduction, Team-Mueller, transgenic},. ...
Lymphotoxin beta Receptor, Lysosphingolipid, Mammalian, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, NF-kappa B, ... Lymphotoxin beta Receptor, Lysosphingolipid, Mammalian, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, NF-kappa B, ... Receptor, Receptor Activator of Nuclear Factor-kappa B, Regulation, Secondary, Signal Transduction, signaling, Team-Mueller, ... Receptors, RNA, Signal Transduction, Systemic, T-Lymphocytes, Team-Dumortier, Toll-Like Receptor 7, Young Adult ...
Receptors, Lysosphingolipid. _. Top Journals Top journals in which articles about this concept have been published. ... Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet. 2006 Feb; 38(2):245-50. ...
Receptors, Lysosphingolipid. Below are MeSH descriptors whose meaning is more specific than "Receptors, Lysophosphatidic Acid". ... "Receptors, Lysophosphatidic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Receptors, Lysophosphatidic Acid" by people in this website by ... Below are the most recent publications written about "Receptors, Lysophosphatidic Acid" by people in Profiles. ...
G Protein-coupled Receptor Signaling Pathway. *G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide ... Lysosphingolipid and LPA receptors. Drugs. Diseases. GWAS. *Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) ... Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway. *Positive Regulation Of Cytosolic Calcium Ion ...
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway. *G-protein Coupled Receptor Signaling Pathway, ... Lysosphingolipid and LPA receptors. Drugs. *Adenosine triphosphate. *Arsenic trioxide. *Inositol 1,3,4,5-Tetrakisphosphate ... Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway. * ...
S1P Receptor use Receptors, Lysosphingolipid S1P1 Receptor use Receptors, Lysosphingolipid S1P2 Receptor use Receptors, ... S1P3 Receptor use Receptors, Lysosphingolipid S1P4 Receptor use Receptors, Lysosphingolipid S1P5 Receptor use Receptors, ...
S1P Receptor use Receptors, Lysosphingolipid S1P1 Receptor use Receptors, Lysosphingolipid S1P2 Receptor use Receptors, ... S1P3 Receptor use Receptors, Lysosphingolipid S1P4 Receptor use Receptors, Lysosphingolipid S1P5 Receptor use Receptors, ...
S1P Receptor use Receptors, Lysosphingolipid S1P1 Receptor use Receptors, Lysosphingolipid S1P2 Receptor use Receptors, ... S1P3 Receptor use Receptors, Lysosphingolipid S1P4 Receptor use Receptors, Lysosphingolipid S1P5 Receptor use Receptors, ...
1-Phosphate Receptor, Sphingosine use Receptors, Lysosphingolipid 1-Phosphatidyl-D-myo-Inositol-4,5-bisphosphate ... 1A Receptor, 5-Hydroxytryptamine use Receptor, Serotonin, 5-HT1A 1A Receptors, 5-Hydroxytryptamine use Receptor, Serotonin, 5- ... 1B Receptor, 5-Hydroxytryptamine use Receptor, Serotonin, 5-HT1B 1B Receptors, 5-Hydroxytryptamine use Receptor, Serotonin, 5- ... 1,25 Dihydroxycholecalciferol Receptors use Receptors, Calcitriol 1,25 Dihydroxycholecalciferol Receptor use Receptors, ...
... Function. G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems ...
MECHANISM OF PRODUCTION OF SUPHINGOSINE 1-PHOSPHATE AND SIGNAL TRANSDUCTION VIA ITS RECEPTOR. *. Principal Investigator. BANNO ... Involvement and abnormality of lysosphingolipid metabolic enzymes in malignant diseases. *. Principal Investigator. MURATE ... receptor kinase / Ras蛋白質ファミリー / 細胞増殖因子 / Gβγサブユニット / 細胞膜受容体 / Cβγサブユニット / ras蛋白質ファミリー / インシュリン / 活性酸素生成 / 走化性ペプチド / ... Membrane receptor / 生体膜 /
Papillae, taste receptor * Pronase E : 0.15% Carbonate-Phosphate buffer. (see reference) Spielman, A. , Mody, I. , Brand, J. , ... Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity. , PLoS Biol ... The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells During Postnatal Development. , PLoS ONE ... SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5 , J Pharmacol Exp Ther ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Receptors, Lysophospholipid Receptores de Lisofosfolipídeos Receptores Lisofosfolípidos Receptors, Lysosphingolipid Receptores ... Receptor X Retinóide alfa Receptor alpha X Retinoide Retinoid X Receptor beta Receptor X Retinóide beta Receptor beta X ... Receptor alfa de Estrogênio Receptor alpha de Estrogeno Estrogen Receptor beta Receptor beta de Estrogênio Receptor beta de ... Factor 1 Asociado a Receptor de TNF TNF Receptor-Associated Factor 2 Fator 2 Associado a Receptor de TNF Factor 2 Asociado a ...
Retinoid X Receptors Receptores X Retinoide Receptores de Lisoesfingolipídeo Receptors, Lysosphingolipid Receptores ... Retinoid X Receptor alpha Receptor alpha X Retinoide Receptor X Retinóide beta Retinoid X Receptor beta Receptor beta X ... Retinoid X Receptor gamma Receptor gamma X Retinoide Receptor alfa de Estrogênio Estrogen Receptor alpha Receptor alpha de ... Factor 1 Asociado a Receptor de TNF Fator 2 Associado a Receptor de TNF TNF Receptor-Associated Factor 2 Factor 2 Asociado a ...
  • The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (harvard.edu)
  • It is now known that sphingosine-1-phosphate receptors (S1P receptors) are members of the lysophospholipid receptor family. (wikipedia.org)
  • A subfamily of lysophospholipid receptors with specificity for LYSOPHOSPHATIDIC ACIDS. (jefferson.edu)
  • Sphingosine-1-phosphate (S1P) and S1P-receptor-1 (S1PR1) promote lymphocyte egress from white to red pulp and back to circulation. (ox.ac.uk)
  • Their binding to the receptors blocks lymphocyte migration and are often used as IMMUNOSUPPRESSANTS. (bvsalud.org)
  • Cycles of G-protein-coupled receptor kinase-2 (GRK2) mediated S1PR1 desensitization and resensitization underlie this remarkable behavior. (ox.ac.uk)
  • Originally thought as an intracellular second messenger, it was discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. (wikipedia.org)
  • S1P interaction with its receptor S1PR1 is needed for the egress of immune cells from the lymphoid organs (such as thymus and lymph nodes) into the lymphatic vessels. (wikipedia.org)
  • Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. (jefferson.edu)
  • Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. (uchicago.edu)
  • The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retractions. (multispaninc.com)
  • Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. (multispaninc.com)
  • Most of the biological effects of S1P are mediated by signaling through the cell surface receptors. (wikipedia.org)
  • This is a "connection" page, showing publications Beichu Guo has written about Receptors, Lysosphingolipid. (musc.edu)
  • This graph shows the total number of publications written about "Receptors, G-Protein-Coupled" by people in Harvard Catalyst Profiles by year, and whether "Receptors, G-Protein-Coupled" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (harvard.edu)
  • S1P5 or EDG8 is a 400-amino acid 7 transmembrane protein that shares 42-49% amino acid identity with the human S1P receptors EDG1, EDG3, and EDG5. (multispaninc.com)
  • Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)
  • Inhibition of S1P receptors was shown to be critical for immunomodulation. (wikipedia.org)
  • Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. (cnrs.fr)
  • The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and maturation by activating G protein-coupled sphingosine 1-phosphate receptors. (nih.gov)
  • Agents that affect the function of G-protein coupled SPHINGOSINE 1- PHOSPHATE RECEPTORS. (bvsalud.org)
  • It is now known that sphingosine-1-phosphate receptors (S1P receptors) are members of the lysophospholipid receptor family. (wikipedia.org)
  • Furthermore, the mRNA levels of another S1P degrading enzyme, S1P phosphatase 1, S1P transporters, spinster homolog 2, adenosine triphosphate-binding cassette subfamily C member 1, and S1P receptors, S1P2 and S1P3 were also increased, but the S1P levels were not increased in the colon cancer tissues. (medscape.com)
  • CONCLUSION: In human colon cancer tissues, mRNA levels of S1P-generating and S1P-degrading enzymes, transporters from inside to outside the cells, and S1P receptors, S1P2 and S1P3 were elevated, suggesting active S1P metabolism and movement. (medscape.com)
  • Although all three S1P receptor isoforms were expressed in AVN tissues, S1P1 receptor isoform expression level was higher than S1P2 and S1P3. (ox.ac.uk)
  • Mechanistically, your LPA-induced rise in Biosynthetic bacterial 6-phytase ALDH-positive cellular material was dependent on intracellular calcium ion (Ca2+), and also the rise in Ca2+ had been suppressed by a selective chemical of short-term receptor prospective cation funnel subfamily H associate Several (TRPC3). (pi3k-receptor.com)
  • However, the extracellular domain of the S1P 1 receptor adopts a novel fold incorporating helical elements from the N-terminus (red ribbon), as well as ECL1 (gold ribbon), that occlude access to the ligand binding pocket. (nih.gov)
  • Originally thought as an intracellular second messenger, it was discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. (wikipedia.org)
  • Here, we show that the sphingosine 1-phosphate receptor (S1PR) modulator fingolimod (FTY720) ameliorated chronic progressive experimental autoimmune encephalomyelitis in nonobese diabetic mice, an experimental model that resembles several aspects of SPMS, including neurodegeneration and disease progression driven by the innate immune response in the CNS. (nih.gov)
  • Fingolimod/Gilenya (FTY720), an oral medication for relapsing-remitting multiple sclerosis, targets S1P₁ receptors on immune and neural cells to suppress neuroinflammation. (nih.gov)
  • The sphingosine-1-phosphate (S1P) receptor modulator, fingolimod (FTY720), has been used for the treatment of patients with relapsing forms of multiple sclerosis, but atrioventricular (AV) conduction block have been reported in some patients after the first dose. (ox.ac.uk)
  • All of us found out that lysophosphatidic acidity (LPA) receptor Several has been very depicted in ALDH-positive TNBC cellular material. (pi3k-receptor.com)
  • Extracellular access to the binding pocket is occluded by the amino terminus and extracellular loops of the receptor. (nih.gov)
  • Sphingosine 1-phosphate receptor 1 (S1P₁), an abundantly-expressed G protein-coupled receptor which regulates key vascular and immune responses, is a therapeutic target in autoimmune diseases. (nih.gov)
  • This process depends on a channel-shaped protein called the ryanodine receptor, or RYR1 for short. (elifesciences.org)
  • S1P interaction with its receptor S1PR1 is needed for the egress of immune cells from the lymphoid organs (such as thymus and lymph nodes) into the lymphatic vessels. (wikipedia.org)