A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, and containing the type species PARVOVIRUS B19, HUMAN.
Virus infections caused by the PARVOVIRIDAE.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MINUTE VIRUS OF MICE.
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with rubella.
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Ingestion of a greater than optimal quantity of food.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Area in the hypothalamus bounded medially by the mammillothalamic tract and the anterior column of the FORNIX (BRAIN). The medial edge of the INTERNAL CAPSULE and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE.
A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
RNA which does not code for protein but has some enzymatic, structural or regulatory function. Although ribosomal RNA (RNA, RIBOSOMAL) and transfer RNA (RNA, TRANSFER) are also untranslated RNAs they are not included in this scope.
A class of untranslated RNA molecules that are typically greater than 200 nucleotides in length and do not code for proteins. Members of this class have been found to play roles in transcriptional regulation, post-transcriptional processing, CHROMATIN REMODELING, and in the epigenetic control of chromatin.
The collection, preparation, and distribution of news and related commentary and feature materials through such media as pamphlets, newsletters, newspapers, magazines, radio, motion pictures, television, and books. While originally applied to the reportage of current events in printed form, specifically newspapers, with the advent of radio and television the use of the term has broadened to include all printed and electronic communication dealing with current affairs.
A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.
The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)

Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. (1/7876)

The crystal structure of the extracellular domain of CD94, a component of the CD94/NKG2 NK cell receptor, has been determined to 2.6 A resolution, revealing a unique variation of the C-type lectin fold. In this variation, the second alpha helix, corresponding to residues 102-112, is replaced by a loop, the putative carbohydrate-binding site is significantly altered, and the Ca2+-binding site appears nonfunctional. This structure may serve as a prototype for other NK cell receptors such as Ly-49, NKR-P1, and CD69. The CD94 dimer observed in the crystal has an extensive hydrophobic interface that stabilizes the loop conformation of residues 102-112. The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94.  (+info)

Non-serum-dependent chemotactic factors produced by Candida albicans stimulate chemotaxis by binding to the formyl peptide receptor on neutrophils and to an unknown receptor on macrophages. (2/7876)

Serum-free culture filtrates of six Candida species and Saccharomyces cerevisiae were found to contain chemoattractants for human polymorphonuclear leukocytes (PMNs) and a mouse macrophage-like cell line, J774. The chemotactic factors differed for the PMN and J774 cells, however, in terms of heat stability, kinetics of liberation by the yeast cells, and divalent cation requirements for production. The chemoattractant in Candida albicans culture filtrates appeared to act through the formyl peptide receptor (FPR) of PMNs, since it was found to induce chemotaxis of Chinese hamster ovary (CHO) cells that were expressing the human FPR but did not induce chemotaxis of wild-type CHO cells. The C. albicans culture filtrates also induced migration of PMNs across confluent monolayers of a human gastrointestinal epithelial cell line, T84; migration occurred in the basolateral-to-apical direction but not the reverse direction, unless the epithelial tight junctions were disrupted. J774 cells did not migrate toward the formylated peptide (fMet-Leu-Phe; fMLF), and chemotaxis toward the C. albicans culture filtrate was not inhibited by an FPR antagonist (t-butoxycarbonyl-Met-Leu-Phe), suggesting that a different receptor mediated J774 cell chemotaxis. In conclusion, we have identified a receptor by which a non-serum-dependent chemotactic factor (NSCF) produced by C. albicans induced chemotaxis of PMNs. Additionally, we have shown that NSCF was active across epithelial monolayers. These findings suggest that NSCFs produced by C. albicans and other yeast species may influence host-pathogen interactions at the gastrointestinal tract mucosal surface by inducing phagocytic-cell infiltration.  (+info)

Yops of Yersinia enterocolitica inhibit receptor-dependent superoxide anion production by human granulocytes. (3/7876)

The virulence plasmid-borne genes encoding Yersinia adhesin A (YadA) and several Yersinia secreted proteins (Yops) are involved in the inhibition of phagocytosis and killing of Yersinia enterocolitica by human granulocytes. One of these Yops, YopH, dephosphorylates multiple tyrosine-phosphorylated proteins in eukaryotic cells and is involved in the inhibition of phagocytosis of Y. enterocolitica by human granulocytes. We investigated whether antibody- and complement-opsonized plasmid-bearing (pYV+) Y. enterocolitica inhibits O2- production by human granulocytes in response to various stimuli and whether YopH is involved. Granulocytes were preincubated with mutant strains unable to express YadA or to secrete Yops or YopH. O2- production by granulocytes during stimulation was assessed by measuring the reduction of ferricytochrome c. PYV+ Y. enterocolitica inhibited O2- production by granulocytes incubated with opsonized Y. enterocolitica or N-formyl-Met-Leu-Phe (f-MLP). This inhibitory effect mediated by pYV did not affect receptor-independent O2- production by granulocytes in response to phorbol myristate acetate, indicating that NADPH activity remained unaffected after activation of protein kinase C. The inhibition of f-MLP-induced O2- production by granulocytes depends on the secretion of Yops and not on the expression of YadA. Insertional inactivation of the yopH gene abrogated the inhibition of phagocytosis of antibody- and complement-opsonized Y. enterocolitica by human granulocytes but not of the f-MLP-induced O2- production by granulocytes or tyrosine phosphorylation of granulocyte proteins. These findings suggest that the specific targets for YopH are not present in f-MLP receptor-linked signal transduction and that other Yop-mediated mechanisms are involved.  (+info)

gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. (4/7876)

We define by molecular, pharmacologic, and physiologic approaches the proximal mechanism by which the immunoglobulin superfamily member gp49B1 inhibits mast cell activation mediated by the high affinity Fc receptor for IgE (FcepsilonRI). In rat basophilic leukemia-2H3 cells expressing transfected mouse gp49B1, mutation of tyrosine to phenylalanine in either of the two immunoreceptor tyrosine-based inhibitory motifs of the gp49B1 cytoplasmic domain partially suppressed gp49B1-mediated inhibition of exocytosis, whereas mutation of both abolished inhibitory capacity. Sodium pervanadate elicited tyrosine phosphorylation of native gp49B1 and association of the tyrosine phosphatases src homology 2 domain-containing phosphatase-1 (SHP-1) and SHP-2 in mouse bone marrow-derived mast cells (mBMMCs). SHP-1 associated transiently with gp49B1 within 1 min after coligation of gp49B1 with cross-linked FcepsilonRI in mBMMCs. SHP-1-deficient mBMMCs exhibited a partial loss of gp49B1-mediated inhibition of FcepsilonRI-induced exocytosis at concentrations of IgE providing optimal exocytosis, revealing a central, but not exclusive, SHP-1 requirement in the counter-regulatory pathway. Coligation of gp49B1 with cross-linked FcepsilonRI on mBMMCs inhibited early release of calcium from intracellular stores and subsequent influx of extracellular calcium, consistent with SHP-1 participation. Because exocytosis is complete within 2 min in mBMMCs, our studies establish a role for SHP-1 in the initial counter-regulatory cellular responses whereby gp49B1 immunoreceptor tyrosine-based inhibition motifs rapidly transmit inhibition of FcepsilonRI-mediated exocytosis.  (+info)

Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. (5/7876)

Rat Sertoli cells phagocytose apoptotic spermatogenic cells, which consist mostly of spermatocytes, in primary culture by recognizing phosphatidylserine (PS) exposed on the surface of degenerating spermatogenic cells. We compared the mode of phagocytosis using spermatogenic cells at different stages of spermatogenesis. Spermatogenic cells were separated into several groups based on their ploidy, with purities of 60-90%. When the fractionated spermatogenic cell populations were subjected to a phagocytosis assay, cells with ploidies of 1n, 2n, and 4n were almost equally phagocytosed by Sertoli cells. All the cell populations exposed PS on the cell surface, and phagocytosis of all cell populations was similarly inhibited by the addition of PS-containing liposomes. Class B scavenger receptor type I (SR-BI), a candidate for the PS receptor, was detected in Sertoli cells. Overexpression of the rat SR-BI cDNA increased the PS-mediated phagocytic activity of Sertoli cell-derived cell lines. Moreover, phagocytosis of spermatogenic cells by Sertoli cells was inhibited in the presence of an anti-SR-BI antibody. Finally, the addition of high density lipoprotein, a ligand specific for SR-BI, decreased both phagocytosis of spermatogenic cells and incorporation of PS-containing liposomes by Sertoli cells. In conclusion, SR-BI functions at least partly as a PS receptor, enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.  (+info)

An Lrp-like protein of the hyperthermophilic archaeon Sulfolobus solfataricus which binds to its own promoter. (6/7876)

Regulation of gene expression in the domain Archaea, and specifically hyperthermophiles, has been poorly investigated so far. Biochemical experiments and genome sequencing have shown that, despite the prokaryotic cell and genome organization, basal transcriptional elements of members of the domain Archaea (i.e., TATA box-like sequences, RNA polymerase, and transcription factors TBP, TFIIB, and TFIIS) are of the eukaryotic type. However, open reading frames potentially coding for bacterium-type transcription regulation factors have been recognized in different archaeal strains. This finding raises the question of how bacterial and eukaryotic elements interact in regulating gene expression in Archaea. We have identified a gene coding for a bacterium-type transcription factor in the hyperthermophilic archaeon Sulfolobus solfataricus. The protein, named Lrs14, contains a potential helix-turn-helix motif and is related to the Lrp-AsnC family of regulators of gene expression in the class Bacteria. We show that Lrs14, expressed in Escherichia coli, is a highly thermostable DNA-binding protein. Bandshift and DNase I footprint analyses show that Lrs14 specifically binds to multiple sequences in its own promoter and that the region of binding overlaps the TATA box, suggesting that, like the E. coli Lrp, Lrs14 is autoregulated. We also show that the lrs14 transcript is accumulated in the late growth stages of S. solfataricus.  (+info)

Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. (7/7876)

The tumor suppressor RB regulates diverse cellular processes such as G1/S transition, cell differentiation, and cell survival. Indeed, Rb-knockout mice exhibit phenotypes including ectopic mitosis, defective differentiation, and extensive apoptosis in the neurons. Using differential display, a novel gene, Rig-1, was isolated based on its elevated expression in the hindbrain and spinal cord of Rb-knockout embryos. The longest open reading frame of Rig-1 encoded a polypeptide that consists of a putative extracellular segment with five immunoglobulin-like domains and three fibronectin III-like domains, a putative transmembrane domain, and a distinct intracellular segment. The Rig-1 sequence was 40% identical to the recently identified roundabout protein. Consistent with the predicted transmembrane nature of the protein, Rig-1 protein was present in the membranous fraction. Antisera raised against the putative extracellular and intracellular segments of Rig-1 reacted with an approximately 210-kDa protein in mouse embryonic CNS. Rig-1 mRNA was transiently expressed in the embryonic hindbrain and spinal cord. Elevated levels of Rig-1 mRNA and protein were found in Rb-/- embryos. Ectopic expression of a transmembrane form of Rig-1, but not the secreted form, promoted neuronal cell entrance to S phase and repressed the expression of a marker of differentiated neuron, Talpha1 tubulin. Thus Rig-1, a possible distant relative of roundabout, may mediate some of the pleiotropic roles of RB in the developing neurons.  (+info)

Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. (8/7876)

The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes inhibit signal transduction. FKBP12 is a ubiquitous, highly conserved, abundant enzyme that catalyzes a rate-limiting step in protein folding: peptidyl-prolyl cis-trans isomerization. However, FKBP12 is dispensible for viability in both yeast and mice, and therefore does not play an essential role in protein folding. The functions of FKBP12 may involve interactions with a number of partner proteins, and a few proteins that interact with FKBP12 in the absence of FK506 or rapamycin have been identified, including the ryanodine receptor, aspartokinase, and the type II TGF-beta receptor; however, none of these are conserved from yeast to humans. To identify other targets and functions of FKBP12, we have screened for mutations that are synthetically lethal with an FKBP12 mutation in yeast. We find that mutations in HMO1, which encodes a high mobility group 1/2 homolog, are synthetically lethal with mutations in the yeast FPR1 gene encoding FKBP12. Deltahmo1 and Deltafpr1 mutants share two phenotypes: an increased rate of plasmid loss and slow growth. In addition, Hmo1p and FKBP12 physically interact in FKBP12 affinity chromatography experiments, and two-hybrid experiments suggest that FKBP12 regulates Hmo1p-Hmo1p or Hmo1p-DNA interactions. Because HMG1/2 proteins are conserved from yeast to humans, our findings suggest that FKBP12-HMG1/2 interactions could represent the first conserved function of FKBP12 other than mediating FK506 and rapamycin actions.  (+info)

TY - JOUR. T1 - Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. AU - Maeda, Akito. AU - Kurosaki, Mari. AU - Ono, Masao. AU - Takai, Toshiyuki. AU - Kurosaki, Tomohiro. PY - 1998/4/20. Y1 - 1998/4/20. N2 - Paired immunoglobulin-like receptor B (PIR-B) (p91) molecule has been proposed to function as an inhibitory receptor in B cells and myeloid lineage cells. We demonstrate here that the cytoplasmic region of PIR-B is capable of inhibiting B cell activation. Mutational analysis of five cytoplasmic tyrosines indicate that tyrosine 771 in the motif VxYxxL plays the most crucial role in mediating the inhibitory signal. PIR-B-mediated inhibition was markedly reduced in the SH2-containing protein tyrosine phosphatases SHP- 1 and SHP-2 double-deficient DT40 B cells, whereas this inhibition was unaffected in the inositol polyphosphate 5-phosphatase SHIP-deficient cells. These data demonstrate that ...
NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatically, suggesting that impaired NK cell function might contribute to disease in these individuals. We found an increased frequency of NK cells with high expression of the inhibitory killer cell lectin-like receptor G1 (KLRG1) in individuals |70 y. The role of KLRG1 in ageing is not known, and the mechanism of KLRG1-induced inhibition of NK cell function is not fully understood. We report that NK cells with high KLRG1 expression spontaneously activate the metabolic sensor AMP-activated protein kinase (AMPK) and that activation of AMPK negatively regulates NK cell function. Pre-existing AMPK activity is further amplified by ligation of KLRG1 in these cells, which leads to internalization of the receptor and allows interaction with
NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatically, suggesting that impaired NK cell function might contribute to disease in these individuals. We found an increased frequency of NK cells with high expression of the inhibitory killer cell lectin-like receptor G1 (KLRG1) in individuals |70 y. The role of KLRG1 in ageing is not known, and the mechanism of KLRG1-induced inhibition of NK cell function is not fully understood. We report that NK cells with high KLRG1 expression spontaneously activate the metabolic sensor AMP-activated protein kinase (AMPK) and that activation of AMPK negatively regulates NK cell function. Pre-existing AMPK activity is further amplified by ligation of KLRG1 in these cells, which leads to internalization of the receptor and allows interaction with
Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. Cluster of differentiation ENSG00000274587, ENSG00000277816, ENSG00000204577 GRCh38: Ensembl ...
TY - JOUR. T1 - Structure of the human NK cell triggering receptor NKp46 ectodomain. AU - Ponassi, Marco. AU - Cantoni, Claudia. AU - Biassoni, Roberto. AU - Conte, Romana. AU - Spallarossa, Andrea. AU - Pesce, Alessandra. AU - Moretta, Alessandro. AU - Moretta, Lorenzo. AU - Bolognesi, Martino. AU - Bordo, Domenico. PY - 2003/9/19. Y1 - 2003/9/19. N2 - NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ...
Clone REA899 recognizes the B isoform of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIRs functions as receptors for class I MHC antigens. PIR-B down-regulates antigen-induced B cell-activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).Additional information: Clone REA899 displays negligible binding to Fc receptors. | Ireland
LILRA2 [ENSP00000251377]. Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding ...
UL18 is a human CMV (HCMV) MHC class I (MHCI) homolog that efficiently inhibits leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)+ NK cells. We found an association of LILRB1 polymorphisms in the regulatory regions and ligand-binding domains with control of HCMV in transplant patients. Naturally occurring LILRB1 variants expressed in model NK cells showed functional differences with UL18 and classical MHCI, but not with HLA-G. The altered functional recognition was recapitulated in binding assays with the binding domains of LILRB1. Each of 4 nonsynonymous substitutions in the first 2 LILRB1 immunoglobulin domains contributed to binding with UL18, classical MHCI, and HLA-G. One of the polymorphisms controlled addition of an N-linked glycan, and that mutation of the glycosylation site altered binding to all ligands tested, including enhancing binding to UL18. Together, these findings indicate that specific LILRB1 alleles that allow for superior immune evasion by HCMV are ...
LILRA4 antibody [N2C2], Internal (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4) for IHC-P, WB. Anti-LILRA4 pAb (GTX119457) is tested in Human samples. 100% Ab-Assurance.
Recombinant Human LILRB1 is produced by our Mammalian expression system and the target gene encoding Gly24-His458 is expressed with a 6His tag at the C-terminus. Bon Opus Cat.# C484 (BP161)
Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers could provide additional information likely to guide critical illness management. We evaluated the prognostic value of soluble Triggering Receptor Expressed by Myeloid cells 1 (sTREM-1), procalcitonin (PCT) and leucocyte surface expression of CD64. This was a prospective cohort study, which included 190 septic patient admitted to the ICU in two hospitals. Blood samples for biomarker measurements were obtained upon admission and thereafter. The Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA) score were calculated. The primary outcome was all-cause death in the ICU. The mortality rate reached 25.8 %. The best predictive value of the three biomarkers was obtained with baseline sTREM-1, although clinical scores outperformed this. Accuracy was greater in
Clone REA1016 recognizes the mouse killer cell lectin-like receptor G1 (KLRG1) antigen. KLRG1 is a homodimeric type II transmembrane glycoprotein of 30-38 kDa subunits. The protein is the mouse homolog of the rat mast cell function-associated antigen (MAFA) and is expressed on a subset of NK cells and T cells. Several members of the cadherin family can interact with KLRG1 leading to inhibition of NK cell and T cell effector functions. Additional information: Clone REA1016 displays negligible binding to Fc receptors. - Belgique
A roundabout is generally known as an efficient, safe, and environmentally friendly intersection. Since 2010, the Korea government has taken the lead in constructing roundabouts as part of a special project. During that time, many ideas have been put forward to improve the safety, operation, and design of such roundabouts. In terms of improvements, it is particularly important to understand roundabout gap acceptance behavior. As such, we investigated gap acceptance behaviors at four roundabouts based on field observation during both good weather and rainy conditions. Based on the observed data, roundabout critical gaps were estimated, and a logit model for gap acceptance using various roundabout variables was developed to investigate gap acceptance maneuvering at roundabouts. A total of 2,421 data events for gap acceptance were collected from the field observation. Out of these events, 64.6% of drivers (1,564 drivers) accepted the given gaps and 35.4% of drivers (857 drivers) rejected them.
PIR-A/B, APC, clone: 10-1-PIR, eBioscience™ 25μg; APC PIR-A/B, APC, clone: 10-1-PIR, eBioscience™ Primary Antibodies Pi to Pm
Day 68 is the most gene-poor of any part of Chromosome 3: only four protein-coding genes (browser view). Two are related: ROBO1 and ROBO2 (roundabout homologs 1 and 2).. Roundabout genes were discovered in fly. The roundabout proteins are on the surface of growing axons in the brain, and help them decide whether to cross between the halves of the brain.. Roundabout genes are found as far away as worm, meaning they are at least 550 million years old.. Click here to see the sequence of Day 68 with ROBO1 underlined.. ...
分泌型糖蛋白Slit及其受体Robo最初作为一类重要的神经元轴突导向因子被发现。随着对Slit-Robo信号通路作用机制研究的不断深入,该信号通路还参与血管新生、肿瘤血管发生、炎症、白细胞趋化及血管渗漏等过程。
package Organism; use strict; use warnings; use feature state; sub count { return scalar keys %{ shift-,{Cells} }; } # Input a list of [ x, y ] coords sub insert_cells { my $cells = shift-,{Cells}; for my $r (@_) { $cells-,{ pack ii, @{$r} } = undef } } # Return sorted list of cells in the Organism. # Used for verification and testing the state of the organism. sub get_live_cells { sort { $a-,[0] ,=, $b-,[0] ,, $a-,[1] ,=, $b-,[1] } map { [ unpack ii, $_ ] } keys %{ shift-,{Cells} }; } # Return the list of dead cells surrounding a cell sub get_dead_cells { my ( $cells, $x0, $y0 ) = ( shift-,{Cells}, @_ ); my ( $x1, $x2, $y1, $y2 ) = ( $x0 - 1, $x0 + 1, $y0 - 1, $y0 + 1 ); state ( $k1, $k2, $k3, $k4, $k5, $k6, $k7, $k8 ); ( ( $k1 = pack ii, $x1, $y1 ) x !( 0 + exists $cells-,{ $k1 } ), ( $k2 = pack ii, $x1, $y0 ) x !( 0 + exists $cells-,{ $k2 } ), ( $k3 = pack ii, $x1, $y2 ) x !( 0 + exists $cells-,{ $k3 } ), ( $k4 = pack ii, $x0, $y1 ) x !( 0 + exists $cells-,{ $k4 } ), ( $k5 = ...
As shown by RNA in situ hybridization in rat (supplemental Figs. 1A-C, 3A, available at www.jneurosci.org as supplemental material) as well as in mouse (data not shown) embryos, Slit2 and Slit3 are highly expressed around the eye in E13 rat and E11.5 mouse embryos (which represent developmentally equivalent stages in the two species). Because Slit1 is not detected there, we first examined Slit2;Slit3 mutant embryos (n = 4). We found that the bottom structure was unaffected in the mutant, but the top structure was dramatically reduced in size when compared with stage-matched littermates (Fig. 1 B). The ratio of the top and the bottom branching areas was reduced by twofold to 0.69 ± 0.30 in the double mutants (Fig. 1 C), and this reduction reflects a change in both branching and neurite growth, because the ratio of the number of branching points or the ratio of branch lengths is also reduced to 0.61 ± 0.36 or 0.56 ± 0.23, respectively, in the mutant from 1.16 ± 0.34 or 1.27 ± 0.22 in the wild ...
Create words, four-letters or more in length, using the Roundabout letters below. Each letter can only be used once in your word and your word must always include the center letter. Do not use proper names or plurals ...
Results. The serum sRAGE (pg/ml) level was significantly lower in patients compared to healthy controls [515 (64-1887) vs 1542 (627-3159); p , 0.0001]. In paired samples, SF had lower levels compared to corresponding plasma level [102 (51-799) vs 481 (134-1006); p , 0.0001]. The level of S100A12 (ng/ml) was higher in SF (1042; 573-1415) than serum (638; 208-779). Serum sRAGE correlated negatively with S100A12 levels (r = −0.474; p , 0.01.), ESR (r = −0.306; p , 0.01), and SJC (r = −0.237; p , 0.05), but not with TJC (r = −0.134; p = NS). The levels of sRAGE remained stable over time in patients with stable disease. ...
Eric, madwifi-lists, I have been able to avoid the AP crashing by using another version of madwifi (I tried using voyage-0.6.5 which contains madwifi in version madwifi-trunk 0.9.4+r4099 as mentioned in the link posted by Eric). It really seemed to be a problem which overloaded the CPU. I come up with this idea, because I have a small display attached via serial line to the ALIX-AP-board and the display was really dull once the error occurred, but sometimes it still reacted - S-L-O-W-L-Y. So now, the error is gone, no more crashing - at least during the last 5 hours, but since the problem usually occurred within 20 minutes, I am very confident. Using a newer version of madwifi solved it. BUT now, I see something else. I am still loading the link heavily with the scp I mentioned before. Roundabout 6 minutes after booting the two ALIX-boards, the connection becomes very laggy. I am pinging the machine, that I am doing the scp to with the very same machine, that does the scp and the ping-times go ...
At the roundabout Rond-Point Kilometre Delta take the 2nd exit Boulevard Pasteur Marc Boegner/N106 towards Alès / Sommières / Le Vigan ...
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TREM1大鼠单克隆抗体[L5-B8.2A12.3A12](ab86256)可与小鼠样本反应并经Flow Cyt实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Title: Alternative Routes for the Formation of Immunochemically Distinct Advanced Glycation End-products In Vivo. VOLUME: 1 ISSUE: 3. Author(s):Masayoshi Takeuchi and Zenji Makita. Affiliation:Department of Biochemistry, Faculty of Pharmaceutical Science, Hokuriku University, 3-Ho Kanagawa-machi, Kanazawa 920-1181, Japan. Keywords:Advanced Glycation End-products, glycation end-products (AGEs), N-carboxymethyllysine (CML), Pyrraline, Pentosidine, Crossline, Imidazolones, Arg-Lys Imidazole (ALI), Vesperlysine A, Argpyrimidine. Abstract: The advanced stage of the glycation process (also called the Maillard reaction) that leads to the formation of advanced glycation end-products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients and in the aging process. AGEs elicit a wide range of cell-mediated responses that might contribute to diabetic complications, vascular disease, renal disease, and Alzheimer disease. Recently, it has been proposed that AGE are not only ...
Advanced glycation end products (AGEs) are critically involved in atherogenesis in diabetes by binding to receptors for AGE (RAGEs) in vascular cells, thus inducing the expression of proinflammatory mediators. In animal models, interruption of the AGE-RAGE interaction reduces lesion size and plaque development. Therefore, limiting RAGE expression might be an intriguing concept to modulate vascular disease in diabetic patients. The present study investigated whether thiazolidinediones (TZDs), antidiabetic agents clinically used to treat patients with type 2 diabetes, might modulate endothelial RAGE expression. Stimulation of human endothelial cells with rosiglitazone or pioglitazone decreased basal as well as tumor necrosis factor-α-induced RAGE cell surface and total protein expression. In addition, TZDs reduced RAGE mRNA expression in endothelial cells. These effects on RAGE expression were caused by an inhibition of nuclear factor-κB (NF-κB) activation at the proximal NF-κB site of the ...
Title:The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated Diseases. VOLUME: 20 ISSUE: 6. Author(s):Tejinder Pal Khaket, Sun Chul Kang* and Tapan Kumar Mukherjee*. Affiliation:Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Haryana. Keywords:Lung, RAGE, inflammation, pulmonary diseases, anti-RAGE therapy, lung epithelial cells.. Abstract:The receptor for advanced glycation end products (RAGE) is a multi-ligand pattern recognition receptor that is highly expressed in lung epithelial cells. It helps alveolar epithelial cells to maintain their morphology and specific architecture. However, in various pathophysiological conditions, pulmonary tissues express a supraphysiological level of RAGE and its ligands including advanced glycation end products, high mobility group box 1 ...
Clinical trial for Pleural Effusion , Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion
This is the second in a series of articles designed to provide important information about key metabolic processes that are really important to understand for optimizing our quality of life - and yet almost no one in the general public has any awareness of them at all.. The first article addressed methylation: an important biochemical process in our bodies that is important for many health issues. Here is a link to the article.. This article addresses another very important metabolic process:. Advanced Glycation End Products (AGEs).. What exactly are Advanced Glycation End Products (AGEs)? Here is a great description of what AGEs are:. Advanced Glycation End Products (AGEs) are basically the nasty by-products of glucose metabolism. The typical Western Diet, coupled with a sedentary lifestyle, too much fat, and insulin resistance, leaves our bodies churning out excess glucose and unable to burn it. It stays in our blood stream too long and there it does incredible damage.. One of the most ...
Clearance of apoptotic cells by macrophages and other phagocytic cells, called efferocytosis, is a central process in the resolution of inflammation. Although the receptor for advanced glycation end products (RAGE) has been shown to participate in a variety of acute and chronic inflammatory processes in the lungs and other organs, a role for RAGE in efferocytosis has not been reported. In the present studies, we examined the potential involvement of RAGE in efferocytosis. Macrophages from transgenic RAGE-/- mice showed a decreased ability to engulf apoptotic neutrophils and thymocytes. Pretreatment of RAGE+/+ macrophages with advanced glycation end products, which competitively bind to RAGE, or Abs against RAGE diminished phagocytosis of apoptotic cells. Overexpression of RAGE in human embryonic kidney 293 cells resulted in an increased ability to engulf apoptotic cells. Furthermore, we found that incubation with soluble RAGE enhances phagocytosis of apoptotic cells by both RAGE+/+ and RAGE-/- ...
TY - JOUR. T1 - Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis. AU - Uekita, Hironori. AU - Ishibashi, Toshiyuki. AU - Shiomi, Masashi. AU - Koyama, Hidenori. AU - Ohtsuka, Shukuko. AU - Yamamoto, Hiroshi. AU - Yamagishi, Shoichi. AU - Inoue, Hiroyoshi. AU - Itabe, Hiroyuki. AU - Sugimoto, Koichi. AU - Kamioka, Masashi. AU - Ohkawara, Hiroshi. AU - Wada, Ikuo. AU - Yasuchika, Takeishi. PY - 2019/1/1. Y1 - 2019/1/1. N2 - An advanced glycation end products (AGE)/a receptor for AGE (RAGE) axis plays a central role in the pathogenesis of diabetic vascular remodeling. This study was conducted to clarify the role of RAGE in nondiabetic atherosclerosis. We used the aortic and coronary atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbits prone to myocardial infarction (WHHLMI) at 1 to 14 months. Immunohistochemistry demonstrated the significant expression of RAGE as early as at 1 month with the stronger expression at 3 and 7 ...
TY - JOUR. T1 - Anti-RAGE and Aβ immunoglobulin levels are related to dementia level and cognitive performance. AU - Wilson, Jennifer S.. AU - Mruthinti, Shyamala. AU - Buccafusco, Jerry J.. AU - Schade, Rosann F.. AU - Mitchell, Meghan B.. AU - Harrell, Dean U.. AU - Gulati, Nidhi K.. AU - Miller, L. Stephen. PY - 2009/2/1. Y1 - 2009/2/1. N2 - Background. Blood-based immunoglobulins (IgGs) may mark the presence of amyloid plaques characterizing the progression of Alzheimers disease (AD). Previous studies suggest that anti-RAGE and anti-Aβ IgGs increase proportionately with accumulation of amyloid-beta (Aβ) peptides at receptor sites for advanced glycation end products (RAGE), within cortical areas of brain tissue. We assessed the relationship between these potential markers and an AD-type cognitive profile. We hypothesized that these specific IgG levels would be positively correlated with Clinical Dementia Rating (CDR) scores as well as index scores on the Repeatable Battery for the ...
Determine if an acute glucose load (50g) is associated with an in-vivo and in-vitro increase in the concentration of Advanced Glycation End Products (AGEPs) that, in turn, can impact vascular endothelial reactivity and induce an acute increase in blood pressure. Previous studies generated in the investigators laboratory showed that circulating soluble Receptor for Advanced Glycation End Products (sRAGE) and Tumor Necrosis Factor (TNF)-a (mediator of acute inflammation) are considered markers of the extent of maternal RAGE activation and/or systemic inflammation, respectively ...
Advanced glycation end products and diabetes pdf file Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications. Diabetic vascular complications • Hyperglycemia • Advanced glycation end-​products • Oxidative stress • Inhibitors of glycation. Diabetes mellitus is increasing at.
To the best of our knowledge, our study is the first to demonstrate an association between plasma sRAGE levels and CAD in nondiabetic males. The multivariate-adjusted ORs for CAD revealed that male subjects with sRAGE levels below 776 pg/dL had a 6.719-fold increase in CAD prevalence, independent of established vascular risk factors and lipid parameters. Notably, the independent association between sRAGE levels and CAD was confirmed when analyzing a subgroup of patients with normal levels of LDL cholesterol. This finding appears of interest, because it is estimated that up to half of all CAD cases occur in subjects with moderate to low risk as determined by evaluation of LDL and total cholesterol.3. sRAGE is a soluble receptor produced by alternative splicing of RAGE mRNA21 and is abundantly present in the circulation.22 The mechanism by which plasma sRAGE levels were decreased in CAD patients, however, remains to be clarified. Because sRAGE has been shown to successfully bind to AGEs,30 it has ...
TY - JOUR. T1 - Randomized Trial of an Inhibitor of Formation of Advanced Glycation End Products in Diabetic Nephropathy. AU - Bolton, W. Kline. AU - Cattran, Daniel C.. AU - Williams, Mark E.. AU - Adler, Sharon G.. AU - Appel, Gerald B.. AU - Cartwright, Kenneth. AU - Foiles, Peter G.. AU - Freedman, Barry I.. AU - Raskin, Philip. AU - Ratner, Robert E.. AU - Spinowitz, Bruce S.. AU - Whittier, Frederick C.. AU - Wuerth, Jean Paul. PY - 2004. Y1 - 2004. N2 - Background/Aims: Pimagedine inhibits the formation of advanced glycation end products and slows the progression of diabetic complications in experimental models. This study was undertaken to determine if pimagedine ameliorates nephropathy in type 1 (insulin-dependent) diabetes mellitus. Methods: This was a randomized, double-masked, placebo-controlled study performed in 690 patients with type 1 diabetes mellitus, nephropathy, and retinopathy. The patients received twice daily dosing with placebo, pimagedine 150 mg, or pimagedine 300 mg for ...
Glycation of proteins leads to the formation of early glycation adducts (fructosamine derivatives) and advanced glycation endproducts (AGEs). Formation of AGEs has been linked to the development of cataract, diabetic complications, uraemia, Alzheimers disease and other disorders. AGEs are a group o …
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. As a pattern-recognition receptor capable of binding a diverse range of ligands, it is typically expressed at low levels under normal physiological conditions in the majority of tissues. In contrast, the lung exhibits high basal level expression of RAGE localised primarily in alveolar type I (ATI) cells, suggesting a potentially important role for the receptor in maintaining lung homeostasis. Indeed, disruption of RAGE levels has been implicated in the pathogenesis of a variety of pulmonary disorders including cancer and fibrosis. Furthermore, its soluble isoforms, sRAGE, which act as decoy receptors, have been shown to be a useful marker of ATI cell injury. Whilst RAGE undoubtedly plays an important role in the biology of the lung, it remains unclear as to the exact nature of this contribution under both physiological and pathological conditions.
To assess regulation of cell surface expression of ICAM-1 by the interaction of AGEs with RAGE, HSVEC were incubated with AGE albumin. A dose-dependent increase in cell surface expression of ICAM-1 was noted compared with native albumin (Figure 4b, lanes 2, 3, 4, and 1, respectively). This effect was mediated at least in part by RAGE, as demonstrated by decreased AGE-mediated expression of ICAM-1 in the presence of anti-RAGE IgG but not by nonimmune IgG (Figure 4b, lanes 7 and 8, respectively). In vivo-derived uremic AGEs had similar effects; compared with native albumin, incubation of HSVECs with uremic AGEs resulted in an ≈1.7-fold increase in cell surface expression of ICAM-1 (Figure 4b, lanes 9 and 10, respectively). These effects were mediated in part by RAGE, as demonstrated by reduced expression of ICAM-1 in the presence of anti-RAGE IgG but not by nonimmune IgG (Figure 4b, lanes 11 and 12, respectively).. Because E-selectin mediates targeting of inflammatory cells, particularly ...
We have recently shown that the co-expression and interaction of the receptor for advanced glycation end products (RAGE) and its ligand S100B post myocardial infarction play a role in myocyte apoptosis. In other cell types, the S100B/RAGE interaction triggers signaling pathways including NF-kB activation and translocation, MAP kinases, and p53. To determine the signaling pathways modulated by the S100B/RAGE interaction contributing to myocyte apoptosis, rat neonatal cardiac myocyte cultures transfected with a full-length cDNA of the RAGE gene, a dominant-negative cytoplasmic deletion mutant of RAGE, or vector control were treated with nanomolar (1-1000) concentrations of recombinant bovine brain S100B for 48 hrs. 1 μM S100B induced vector alone-transfected myocyte apoptosis, as evidenced by increased terminal deoxynucleotidyltransferase-mediated UTP end labeling (TUNEL) [12.4±0.7% vs. 5.6±0.3% (untreated) of total cells p,0.05], DNA fragmentation, cytochrome C release from the mytochondria to ...
Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis. Clin Sci (Lond). 2014 Oct; 127(7):485-97 ...
BACKGROUND/AIMS:Our previous report showed that IgG levels are strongly correlated with the indocyanine green (ICG) retention rate in patients with liver cirrhosis (LC). This correlation suggests that hyperglobulinemia in LC could be explained by impairment of hepatic removal function. To estimate IgG turnover in LC, in the present paper was determined the advanced glycation end-products (AGE) on IgG as a marker of half-life.METHODOLOGY:Serum samples were obtained from patients with LC, rheumatoid arthritis (RA), and Sjögren syndrome (SjS), and from age-matched control patients. IgG was purified from serum by the protein G-based affinity method, concentrated by filtration, and used for assay of Nepsilon-(carboxymethyl) lysine (CML), a predominant AGE, by ELISA.RESULTS:CML on IgG was significantly lower in patients with LC than in control patients, whereas there was no significant difference in total serum CML levels among patients with LC, RA, and SjS, and control patients. CML levels on IgG ...
I have recently read an interesting article in Diabetes Care (1) that showed that the low serum level of the endogenous secretory receptor for advanced glycation end products (esRAGE) was independently associated with the prevalence of vertebral fractures in patients with type 2 diabetes. I totally agreed with the authors opinions that bone quality may be more important than bone density in defining the increased risk for fracture in type 2 diabetic patients and that the advanced glycation end product (AGE)-receptor for AGEs (RAGE) system could play a role in impaired bone quality in these patients. However, it seemed unlikely to me that an insufficient amount of esRAGE to counteract AGEs could intensify the binding of AGEs to RAGE and exert harmful effects on bones, thus being involved in the increased risk of vertebral fractures in their patients.. The endogenous soluble form of RAGE (sRAGE) can generate from the cleavage of cell surface full-length RAGE by sheddase or novel splice variants ...
Advanced glycation end products (AGEs) have been introduced to be involved in the pathogenesis of osteoarthritis (OA). The influence of AGEs on osteoarthritic fibroblast-like synovial cells (FLS) has been incompletely understood as yet. The present study investigates a potential influence of AGE-modified bovine serum albumin (AGE-BSA) on cell growth, and on the expression of proinflammatory and osteoclastogenic markers in cultured FLS. FLS were established from OA joints and stimulated with AGE-BSA. The mRNA expression of p27Kip1, RAGE (receptor for AGEs), nuclear factor kappa B subunit p65 (NFκB p65), tumor necrosis factor alpha (TNF-α, interleukin-6 (IL-6), receptor activator of NFκB ligand (RANKL) and osteoprotegerin was measured by real-time PCR. The respective protein expression was evaluated by western blot analysis or ELISA. NFκB activation was investigated by luciferase assay and electrophoretic mobility shift assay (EMSA). Cell cycle analysis, cell proliferation and markers of necrosis and
Advanced glycation end products (AGEs), the final products of nonenzymatic glycation and oxidation of proteins, are found in the plasma and accumulate in the tissues during aging and at an accelerated rate in diabetes. A novel integral membrane protein, termed receptor for AGE (RAGE), forms a centra …
Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J. 1999 Aug 02; 18(15):4250-60 ...
Advanced glycation end products naturally form in our bodies from the chemical reaction of sugars with proteins. How can you limit your AGE intake?
Complete information for SIRPA gene (Protein Coding), Signal Regulatory Protein Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Calcitriol Modulates Cardiac Fibroblasts through Noncanonical Pathway of Receptor for Advanced Glycation End Products and Fibroblast Growth Factor Receptor Signaling: Implicated in Cardiac Fibrosis in ...
Clone TG1 is the first monoclonal antibody detecting TIGIT in routine formalin-fixed paraffin-embedded (FFPE) tissues. TG1 has been validated for the detection of TIGIT positive T-cells with a focus on tumor infiltrating T cells (TILs). Anti-TIGIT clone TG1 allows the identification of TIGIT in the tumor microenvironment under pathological conditions.. TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is a member of the poliovirus receptor (PVR) family. TIGIT is expressed on subsets of T lymphocytes and controls an immune checkpoint. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but TIGIT is not expressed on B cells or naive CD4+ T cells. Naive CD4+ T cells may upregulate TIGIT expression upon activation. In many different cancer models, TIGIT has been shown to be upregulated on T cells. The ligands CD155 and CD112 are also highly expressed on dendritic cells and macrophages in different cancer ...
The pathological role of advanced glycation end products (AGEs) and of oxidative-carbonylic stress is well known in the context of diabetes. Moreover, there is also strong evidence that they play a ...
Dr. Medvedik and guests took a look at the recent publication where two forms of advanced glycation end products (AGEs) were successfully cleaved.
Rabbit polyclonal RAGE antibody validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human, Mouse and Rat. Referenced in 36 publications and 11 independent…
TY - JOUR. T1 - Estimation of air pollutant emissions in flower roundabouts and in conventional roundabouts. AU - Corriere, Ferdinando. AU - Guerrieri, Marco. AU - Ticali, Dario. AU - Guerrieri, Marco. AU - Messineo, Antonio. PY - 2013. Y1 - 2013. N2 - The road pollutant emissions, above all in urban context, are correlated to many infrastructuralparameters and to traffi c intensity and typology. The research work on road junction geometry,carried out in European research centres, has recently allowed to design new road intersectiontypes which are of undoubted interest, especially in terms of traffi c functionality and safety, like thefl ower roundabouts (in which right-turn manoeuvres do not confl ict with the circulating fl ow). Themain objective of this paper is to propose a model for the estimation the capacity, delay, levels ofservice and the pollutant emissions into fl ower roundabouts. A comparative analysis between conventionalroundabout and fl ower roundabout has been carried out in ...
The standard treatment for epithelial ovarian carcinoma (EOC) is surgery followed by platinum/paclitaxel-based chemotherapy, but the overall survival rate is poor. The purpose of this study was to investigate the therapeutic potential of chemotherapy combined with inhibition of B and T lymphocyte attenuator (BTLA) for clinical use to treat EOC. Initially, we evaluated the potential application of chemotherapy combined with anti-BTLA antibody in an animal model. We then analyzed the distribution and regulation of BTLA expression on immunocytes in vitro. Finally, we examined the correlation between BTLA expression levels in cancerous tissues and prognosis in 254 EOC cases. The combination of chemotherapy and anti-BTLA antibody for inhibiting BTLA significantly reduced peritoneal tumor volume and extended survival in tumor-bearing mice. In addition, BTLA could be identified mostly on B lymphocytes, especially on CD19hi B cells, rather than on T lymphocytes and natural killer cells. Under regulation of
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord ...
Mouse gp49 was formerly identified on mast and NK cells. However, in previous studies, only cells cultured in cytokines were examined. In this study, we provide the first comprehensive analysis of the distribution of gp49 on naive, hemopoietic cells. Unexpectedly, we find that resting NK cells lack expression of gp49. Instead, myeloid cells from bone marrow, spleen, and liver, expressing Mac-1 and Gr-1, constitutively express gp49A and B. By contrast, T cells as well as B cells do not express gp49.. Despite that gp49 is not found on naive NK cells, it is induced on NK cells following in vitro and in vivo stimulation. This induced expression is found in NK cell responses to MCMV infection, a notable observation because of the critical role of NK cells in controlling lethality and replication by MCMV (19, 20, 23). Although the mechanism for induction of gp49 expression was not revealed in our studies, NK cells from MCMV-infected IL-12 or IFN-γ-deficient mice were fully capable of gp49 expression. ...
Recombinant protein of human leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), transcript variant a, 20 ug available for purchase from OriGene - Your Gene Company.
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi (1). Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia. During sepsis, a progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase ...
We evaluated the heart using pre- and after-load-independent indices of LV function and found that the blockage of RAGE in diabetic mice from the age of 7 to 12 weeks prevented the development of cardiac dysfunction. dp/dt, which is a complex function influenced by pre- and after-load, was unaffected.[27] Consequently, blockage of RAGE must improve cardiac function by a direct action in the heart.. The function of the heart is dependent on the biophysical properties of the myocardium. As a result, AGE cross-linking has specific consequences for cardiac function. In accordance with this, accumulation of collagen and alterations in myocardial collagen AGEs in the diabetic heart have been demonstrated to decrease myocardial compliance.[15],[28] We found that RAGE blockage normalized LV diastolic chamber stiffness. In addition, the mRNA expression of Col1a1 was normalized in RAGE-blocked diabetic mice. These data indicate that RAGE activation mediates increased collagen AGE formation, which leads to ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14+ cells, macrophages and CD1c+ DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions.: The signaling adaptor protein KARAP/DAP12/TYROBP (killer cell activating receptor-a
Roundabouts are safer than intersections because they reduce the number of potential conflicts between road users and lower the driving speed. In the Netherlands, replacing an intersection by a roundabout is estimated to reduce the number of severe casualties by approximately 46%. The traffic flow is usually better on roundabouts than on intersections, and exhaust emission and noise decrease, certainly when compared with signalized intersections. Roundabouts, however, take up more space. ...
Interaction of RAGE with its ligands can promote tumor progression, invasion and angiogenesis. Although blocking RAGE signaling has been proposed as a potential anti-cancer strategy, functional contributions of RAGE expression in the tumor microenvironment (TME) has not been investigated in detail. Here, we evaluated the effect of genetic depletion of RAGE in TME on the growth of gliomas. In both invasive and non-invasive glioma models, animal survival was prolonged in RAGE knockout (Ager-/-) mice. However, the improvement in survival in Ager-/- mice was not due to changes in tumor growth rate but rather to a reduction in tumor-associated inflammation. Furthermore, RAGE ablation in the TME abrogated angiogenesis by downregulating the expression of pro-angiogenic factors which prevented normal vessel formation, thereby generating a leaky vasculature. These alterations were most prominent in non-invasive gliomas, where the expression of VEGF and pro-inflammatory cytokines were also lower in ...
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
Advanced glycation end-products are considered potent molecules capable of promoting neuronal cell death and participating in the development of neurodegenerative disorders such as Alzheimers disease (Bittencourt LS, et al., 2014). Advanced glycation end-products can be formed several ways. Elevated blood glucose ca
In the current study, we report a crucial role for TLT-1 in regulating leukocyte activation and modulating sepsis-induced acute inflammatory response. A 17-aa residue of its extracellular domain mediates this effect. Whereas treml-1−/− mice are particularly susceptible to infection with the development of an intense inflammatory state that translated into organ damage and rapid mortality, LR17 administration confers a strong protection.. Until recently, the role of TLT-1 has remained unclear. TLT-1 is exclusively expressed in platelets, colocalized with CD62P in α-granules of resting platelets. Upon activation, TLT-1 is quickly exposed on the membrane (24) and subsequently cleaved, leading to the release of a soluble fragment. Structural analysis of the extracellular domain of TLT-1 suggests the existence of several distinct potential ligand binding sites (27). The first TLT-1 ligand was recently identified to be fibrinogen, positioning TLT-1 as a regulator of hemostasis by facilitating ...
Receptor-Mediated Regulation of the Innate Immune System. Our laboratory studies the molecular regulation and function of multiple receptor systems involved the generation and propagation of the innate immune response with the goal of understanding how the innate immune system can be harnessed for the prevention of and/or treatment of cancer. More specifically, we have been studying the signal transduction of regulatory receptors of innate immune cells including monocytes/macrophages, natural killer (NK) cells, and most recently, platelets. Receptor systems recently or currently under study include the KIR and the TREM and TREM-Like Receptors. Recent findings have driven us to become interested in the regulation of innate cell metabolic pathways by these receptor systems and the pathways with which they interact.. The Triggering Receptors Expressed on Myeloid Cells (TREM) and TREM-Like Receptors. One of the best-characterized myeloid DAP12-coupled receptor systems are the triggering receptors ...
CLM-1 is expressed on myeloid cells in CNS inflammatory lesions. (A) CLM-1 mRNA expression in spinal cord after MOG35-55 immunization. Fold induction is calcula
OBJECTIVE Advanced glycation end products (AGEs) and their specific receptor, the receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble form of RAGE (sRAGE) has been identified in human serum. However, the role of sRAGE in cardiovascular disease is still controversial. There is no information on the association between simultaneous measurements of AGEs and sRAGE and vascular function. In this study, we evaluated the associations between serum levels of AGEs and sRAGE, ratio of AGEs to sRAGE, and vascular function. ...
We often talk about the increase in AGEs (Advanced Glycation Endproducts) in patients with diabetes. We mainly think about these AGEs in the develop
Initially, antibodies are attached to the surface of a B cell - they are then referred to as B-cell receptors (BCR). After an ... Rus H, Cudrici C, Niculescu F (2005). "The role of the complement system in innate immunity". Immunologic Research. 33 (2): 103 ... The Fc receptors are isotype-specific, which gives greater flexibility to the immune system, invoking only the appropriate ... In particular, the neonatal Fc receptor (FcRn) binds to the Fc region of IgG antibodies to transport it across the placenta, ...
... and HIV co-receptor activity. HIV-1 most commonly uses the chemokine receptors CCR5 and/or CXCR4 as co-receptors to enter ... Immunologic Research. 27 (2-3): 261-76. doi:10.1385/IR:27:2-3:261. PMID 12857973. S2CID 32006625. Esté JA (Sep 2003). "Virus ... It is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group. CCR5's cognate ligands ... Cutler CW, Jotwani R (2006). "Oral mucosal expression of HIV-1 receptors, co-receptors, and alpha-defensins: tableau of ...
"Chemokine Receptors: CXCR4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Immunologic Research. 27 (2-3): 261-76. doi:10.1385/IR:27:2-3:261. PMID 12857973. S2CID 32006625. Esté JA (September 2003). " ... The protein is a CXC chemokine receptor. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 ... Saini V, Marchese A, Majetschak M (May 2010). "CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin ...
Samter's Immunologic Diseases, 6th ed. Vol. 1, p. 281-298, Philadelphia: Lippincott Williams & Wilkins, ISBN 0-7817-2120-2 ... Phagocytes expressing CR1, CR3, and Fcγ receptors effect a transfer of the immune complexes to their surface. Then erythrocytes ... Because primate erythrocytes express complement receptor 1 (CR1) on their surface and having binding specificity to C4b, C3b, ... "The role of complement and its receptor in the elimination of immune complexes". The New England Journal of Medicine. 315 (8): ...
"Inappropriate sinus tachycardia may be related to an immunologic disorder involving cardiac β andrenergic receptors". Heart ... Nattel, Stanley (October 2006). "Inappropriate sinus tachycardia and beta-receptor autoantibodies: A mechanistic breakthrough ...
Gout S, Morin C, Houle F, Huot J (September 2006). "Death receptor-3, a new E-Selectin counter-receptor that confers migration ... Jennette, J. Charles; Falk, Ronald J. (2008). "Immunologic Mechanisms of Vasculitis". Seldin and Giebisch's the Kidney. pp. ... "E-selectin receptors on human leukocytes". Blood. 112 (9): 3744-52. doi:10.1182/blood-2008-04-149641. PMC 2572800. PMID ... The appropriate set of endothelial receptors is sometimes not expressed constitutively and the cancer cells have to trigger ...
... the epitope can be recognized by immunologic structures like T-cell receptors (TCRs). The molecular region which binds to the ... Antigen presentation: MHC molecules bind to both T cell receptor and CD4/CD8 co-receptors on T lymphocytes, and the antigen ... in addition to T-cell receptors (TCR)s. When a CTL's CD8 receptor docks to a MHC class I molecule, if the CTL's TCR fits the ... since different lymphocytes express different T-Cell Receptor (TCR) co-receptors. MHC class II molecules in humans have five to ...
"Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor". Ann. N. Y. ... Alpha-7 nicotinic receptor Nicotinic acetylcholine receptor Acetylcholine receptor ENSG00000175344, ENSG00000282088 GRCh38: ... "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor ... Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 ...
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of Biological Chemistry. ... Immunologic Research. 28 (3): 193-199. doi:10.1385/ir:28:3:193. PMID 14713714. Iacono, Kathryn T.; Brown, Amy L.; Greene, Mark ... Differences in the Activation of Three Classes of Non-Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor ... I.; Saouaf, Sandra J. (December 2007). "CD147 Immunoglobulin Superfamily Receptor Function and Role in Pathology". Experimental ...
1997). "The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge". Brain Res ... 2003). "Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor ... This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated ... "P2Y Receptors: P2Y14". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
Immunologic adjuvant Sadelain, MW; Qin, HY; Lauzon, J; Singh, B (1990), "Prevention of type I diabetes in NOD mice by adjuvant ... Pancreatic islets express high levels of IL-22 receptor and IL-22 has been shown to induce islet beta cell regeneration. ...
Sulfites may cause reactions by both immunologic and non-immunologic mechanisms. Anaphylaxis is diagnosed on the basis of a ... Antigen-bound IgE then activates FcεRI receptors on mast cells and basophils. This leads to the release of inflammatory ... from certain types of white blood cells triggered by either immunologic or non-immunologic mechanisms. Diagnosis is based on ... typically due to an immunologic reaction but sometimes non-immunologic mechanism. Interleukin (IL)-4 and IL-13 are cytokines ...
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single ... Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. „Proc Natl Acad Sci U S A". 103 (18), ... Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. „Immunity". 3 (4), s ... Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. „ ...
Djeluje uglavnom kao antigenski receptor na B stanicama koje nisu bile izložene antigenom.[16] Pokazalo se je da aktiviraju ... "Immunologic Research 36 (1-3): 27-32. 10.1385/IR:36:1:27. ... and Fc regions and the role of N-glycosylation on Fcα receptor ... Svaka Fc regija određenog izotipa antitijela može se vezati za svoj specifični Fc receptor (osim za IgD, koji je u suštini BCR ... dok se njegova Fc regija veže na Fc receptor ε. Interakcija alergen-IgE-FcRε posreduje alergijski prijenos signala kako bi se ...
NK cells recognize the HLA-E+peptide complex using the heterodimeric receptor CD94/NKG2A/B/C. When CD94/NKG2A or CD94/NKG2B is ... Immunologic Research. 29 (1-3): 81-92. doi:10.1385/IR:29:1-3:081. PMID 15181272. S2CID 29282633.. ... receptors and function". European Journal of Immunology. 32 (5): 1205-11. doi:10.1002/1521-4141(200205)32:5. 3.0.CO;2-Y. PMID ... "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795-9. Bibcode:1998Natur.391..795B. doi: ...
The immunologic function of GM3 in inhibiting proliferation has resulted in its usage in the study of cancer biology and cancer ... GM3 also functions as an inhibitor; it inhibits cell growth, the function of growth factor receptors, and generation of ...
Phagocytosis has an immunologic function and role in apoptosis. Additionally, endocytosis can be observed through the ... More specifically, eukaryotic cells use endocytosis of the uptake of nutrients, down regulation of growth factor receptors' and ... nonspecific internalization of fluid droplets via pinocytosis and in receptor mediated endocytosis. The transport mechanism ...
Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV ... Immunologic Research. 28 (2): 93-107. doi:10.1385/IR:28:2:93. PMID 14610287. S2CID 37296843. Quaranta MG, Mattioli B, Giordani ... Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells. The protein encoded by this gene is expressed ... Turville SG, Cameron PU, Handley A, Lin G, Pöhlmann S, Doms RW, Cunningham AL (2002). "Diversity of receptors binding HIV on ...
Three major classes of these "cytosolic" receptors are NOD-like receptors, RIG (retinoic acid-inducible gene)-like receptors, ... Rus H, Cudrici C, Niculescu F (2005). "The role of the complement system in innate immunity". Immunologic Research. 33 (2): 103 ... Ten toll-like receptors have been described in humans. Cells in the innate immune system have pattern recognition receptors, ... Fc receptor Immune system receptors Immunostimulator Neuroimmune system Original antigenic sin - when the immune system uses ...
Chen L, Du JB, Jin HF, Zhang QY, Li WZ, Wang L, Wang YL (September 2008). "[Effect of selective alpha1 receptor agonist in the ... Immunologic Research. doi:10.1007/s12026-021-09185-5. PMC 8009458. PMID 33786700. Miglis MG, Prieto T, Shaik R, Muppidi S, Sinn ... Especially elevations of adrenergic α1 receptor is associated with symptoms severity in patients with POTS. If POTS is caused ... A high number of patients has elevated levels of autoantibodies against the adrenergic alpha 1 receptor and against the ...
... like receptors, retinoic acid inducible gene-I (RIG-I)-like receptors and C-type lectin-like receptors. They are not only at ... The first immunologic model was called the Self Non-self model and was suggested by Burnet and Frank Fenner in 1949, and ... called alarmins and they are recognized by pattern recognition receptors (PRRs) of APC cells. PRRs include Toll-like receptors ... In 1994 a new immunologic model was suggested by Polly Matzinger. She suggested that the immune system does not distinguish ...
receptor binding. • lipopolysaccharide binding. • lipopeptide binding. Cellular component. • membrane. • extracellular exosome ... The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. ... Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.[8][9][10] ... toll-like receptor signaling pathway. • macromolecule localization. • positive regulation of cytolysis. • transport. ...
Siponimod, (BAF312) is a sphingosine-1-phosphate receptor modulator for oral use for MS. A phase III trial should run from Dec ... critical review of clinical and immunologic effects". Mult. Scler. 8 (2): 142-54. doi:10.1191/1352458502ms790oa. PMID 11990872. ... "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis". Neuron. 90 (5): 948-954. doi:10.1016/j.neuron.2016.04.039. PMC 5092154 ...
determined expression patterns of functional IFN-inducible GTPase genes in Branchiostoma japonicum at various immunologic sites ... japonicum and other amphioxus species do not possess IFN and IFN receptor genes. It is possible that IRGs may have existed ...
An antigen binds the highly variable immunoreceptor products (B-cell receptor or T-cell receptor) once these have been ... The antigen cannot elicit the immune response without the help of an immunologic adjuvant. Similarly, the adjuvant component of ... For T-cell receptor (TCR) recognition, the peptide must be processed into small fragments inside the cell and presented by a ... Tumor antigens can appear on the surface of the tumor in the form of, for example, a mutated receptor, in which case they are ...
"T-Lymphocytes and Their Receptors in Immunologic Recognition, Immunology", 2. köide, 1988, Harwood Academic Publishers, ... Kabelitz D, Wesch D., Features and functions of gamma delta T lymphocytes: focus on chemokines and their receptors. ... Lily Zhang, Judith Sliker Belkowski, Tammi Briscoe, ja Thomas J. Rogers, Regulation of Mu Opioid Receptor Expression in ...
Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2. GRCh38: Ensembl ... The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. ... "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 ... to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4. ...
The disease occurs due to detectable antibodies produced against the human acetylcholine receptor. The receptor contains a ... Not only does HSV cause immunologic cross-reactivity, but the gpD peptide also competitively inhibits the binding of antibody ... Receptor editing is another mechanism for B cell tolerance. This involves the reactivation or maintenance of V(D)J ... B cells that bind with low avidity to self-MHC receptors are positively selected for maturation, those that do not die by ...
Nagpal, Sunil; Na, Songqing; Rathnachalam, Radhakrishnan (1 August 2005). "Noncalcemic Actions of Vitamin D Receptor Ligands". ... Antigen Co-stimulation Immunogenicity Immunologic adjuvant Immunomodulator Immunotherapy Deoxycholic acid, a stimulator of ... Insights from Genetic Models of Hormone and Hormone Receptor Deficiency". Endocrine Reviews. 21 (3): 292-312. doi:10.1210/edrv. ... macrophages Imiquimod and resiquimod, activate immune cells through the toll-like receptor 7 Kumar, S; Gupta P; Sharma S; Kumar ...
Statin may slow progressive MS[permanent dead link] Wang, Z (2016). "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis". ... critical review of clinical and immunologic effects". Mult. Scler. 8 (2): 142-54. doi:10.1191/1352458502ms790oa. PMID 11990872 ... Some researchers think that there could exist also an overlapping between Anti-NMDA receptor encephalitis cases and ... "Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor ...
... anti-NMDA receptor encephalitis and Devic's disease,[23] Graves' ophthalmopathy,[24] autoimmune pancreatitis,[25] Opsoclonus ... "Immunologic and Clinical Responses to Rituximab in a Child With Opsoclonus-Myoclonus Syndrome". Pediatrics. 115 (1): e115-e119 ... with enhanced binding to Fc gamma receptors, which increase ADCC (antibody-dependent cellular cytotoxicity).[55] This strategy ... to induce ADCC takes advantage of the fact that the displayed Fc glycan controls the antibody's affinity for Fc receptors.[56] ...
Within the tick midgut, the Borrelia's outer surface protein A (OspA) binds to the tick receptor for OspA, known as TROSPA. ... this is more common after infection by certain Borrelia strains in people with certain genetic and immunologic characteristics. ... which stimulates the NMDA receptor on nerve cells, which may account for the fatigue and malaise observed with Lyme ...
Later the level of anti-acetylcholine receptor antibodies in disease were found to correlate with B8::DR3.[15] Later it was ... "Immunologic features and HLA associations in chronic viral hepatitis". Gastroenterology. 108 (1): 157-64. doi:10.1016/0016- ... Keesey J, Naeim F, Lindstrom J, Zeller E, Herrmann C, Walford R (1978). "Correlation between acetylcholine receptor antibody ... and anti-acetylcholine receptor antibodies in myasthenia gravis". Tissue Antigens. 12 (5): 381-6. doi:10.1111/j.1399-0039.1978. ...
The ubiquitin receptor Rpn13 binds to Rpn2 and completes the base cub-complex. The lid covers one half of the AAA-ATPase ... "Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases". The Journal of ... The second ubiquitin receptor identified to date, Rpn10, is positioned at the periphery of the lid, near subunits Rpn8 and Rpn9 ... These receptor proteins may escort polyubiquitinated proteins to the proteasome, though the specifics of this interaction and ...
"T cell recognition of weak ligands: roles of signaling, receptor number, and affinity". Immunologic Research. 50 (1): 39-48. ... The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three dimeric signaling modules ... The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for ... TCR co-receptors[edit]. The signal from the T-cell complex is enhanced by simultaneous binding of the MHC molecules by a ...
Secreted IgE circulates in the blood and binds to an IgE-specific receptor (a kind of Fc receptor called FcεRI) on the surface ... Nester, Eugene W.; Anderson, Denise G.; Roberts Jr, C. Evans; Nester, Martha T. (2009). "Immunologic Disorders". Microbiology: ... Cross-linking of the IgE and Fc receptors occurs when more than one IgE-receptor complex interacts with the same allergenic ... 3 - FcεRI receptor. 4 - preformed mediators (histamine, proteases, chemokines, heparin). 5 - granules. 6 - mast cell. 7 - newly ...
Benito-Garcia, E; Schur, PH; Lahita, R; American College of Rheumatology Ad Hoc Committee on Immunologic Testing, Guidelines ( ... "Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective ... Dec 15, 2004). "Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests". ...
Skin immunologic testing (allergy testing) may reveal hyposensitivity. Not all patients have a positive family history of the ... WASp is important because it is known to be activated via T-cell receptor signaling pathways to induce cortical actin ...
Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic.[5] It is usually caused by allergy and occurs ... such as an angiotensin II receptor blocker (ARB)[17] which has a similar mechanism but does not affect bradykinin. However, ... "Investigation of angioedema associated with the use of angiotensin-converting enzyme inhibitors and angiotensin receptor ...
... due to the presence of immune receptors called Toll-Like Receptors (TLRs) that are expressed on the membranes of leukocytes ... Toll-like receptors[edit]. The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in ... "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune ... Takeda K, Akira S (January 2005). "Toll-like receptors in innate immunity". International Immunology. 17 (1): 1-14. doi:10.1093 ...
The ability of T cells to recognize foreign antigens is mediated by the T-cell receptor. The T-cell receptor undergoes genetic ... One of the primary functions of the thymus is to prevent autoimmunity through the process of central tolerance, immunologic ... Each T cell attacks a specific substance which it identifies with its receptor. T cells have receptors which are generated by ... This process is error-prone, and some thymocytes fail to make functional T-cell receptors, whereas other thymocytes make T-cell ...
Chimeric antigen receptors (CARs) have been developed as a promising immunotherapy for ALL. This technology uses a single chain ... This effect has been attributed to making an immunologic space within which the cells populate.[52] The process as a whole ... By engaging the CD3 T-cell with the CD19 receptor on B cells, it triggers a response to induce the release of inflammatory ... T cells purified from each person are modified by a virus that inserts genes that encode a chimaeric antigen receptor into ...
... as well as inhibit the inhibitory effect of adenosine receptors on dopamine receptors,[67] however the implications for humans ... Commonly used tests include chromatography, immunologic assay, and mass spectrometry.[129] See also[edit]. *Antipsychotics ... Kamiya T, Saitoh O, Yoshioka K, Nakata H (June 2003). "Oligomerization of adenosine A2A and dopamine D2 receptors in living ... Adrenergic stimulants, such as ephedrine, may act by directly binding and activating the receptors that norepinephrine and ...
The human microbiome may play a role in the activation of toll-like receptors in the intestines, a type of pattern recognition ... Microbiota have been found to be crucial for immunologic, hormonal and metabolic homeostasis of their host. The synonymous term ... receptor host cells use to recognize dangers and repair damage. Pathogens can influence this coexistence leading to immune ...
Protein tyrosine phosphatase receptor type O, also known as glomerular epithelial protein 1 (GLEPP1), has been shown to be ... Rather, an altered cell-mediated immunologic response with abnormal secretion of lymphokines by T cells is thought to reduce ...
Immunologic barriers[edit]. To date no xenotransplantation trials have been entirely successful due to the many obstacles ... soluble complement receptor type 1, anti-C5 antibodies, or C1 inhibitor (C1-INH). Disadvantages of this approach include the ... 4.1 Immunologic barriers *4.1.1 Hyperacute rejection *4.1.1.1 Overcoming hyperacute rejection ... Takahashi, T.; Saadi, S.; Platt, J. L. (1997). "Recent advances in the immunology of xenotransplantation". Immunologic Research ...
The precise mechanism is unclear and it could be immunologic, although not through the IgE-type antibodies that have the ... Because most naturally occurring phytoestrogens act as selective estrogen receptor modulators, or SERMs, which do not ... "Selective Estrogen Receptor Modulators and Phytoestrogens". Planta Med. 74 (13): 1656-65. doi:10.1055/s-0028-1088304. PMC ... necessarily act as direct agonists of estrogen receptors, normal consumption of foods that contain these phytoestrogens should ...
Sajjad Y, Quenby S, Nickson P, Lewis-Jones DI, Vince G., Androgen receptors are expressed in a variety of human fetal ... immunologic and safety evaluations in 12 patients, BLOOD, 1. august 2003, 102. köide, number 3, (vaadatud 16.09.2014) ... Jean M. Bidlack, Detection and Function of Opioid Receptors on Cells from the Immune System, Clin Vaccine Immunol, september ... Jean M. Bidlack, Detection and Function of Opioid Receptors on Cells from the Immune System, Clin Vaccine Immunol, september ...
Immunologic mechanisms of rejection[edit]. Rejection is an adaptive immune response via cellular immunity (mediated by killer T ... The IgG's Fc region also enables opsonization by a phagocyte, a process by which the Fc receptor on the phagocyte-such as ... When memory helper T cells' CD4 receptors bind to the MHC class II molecules which are expressed on the surfaces of the target ... In the living donor, such presentation of self antigens helped maintain self tolerance.) Thereupon, the T cell receptors (TCRs ...
In Austen KF, Frank K, Atkinson JP, Cantor H. (ed.) Samter's Immunologic Diseases (6th ed.) Vol. 1, p. 281-298, Philadelphia: ... Complement Peptide C5a, C4a, and C3a Receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... Upon immunisation with an antigen, more of these receptors are formed, and they are then shed from the cells to circulate in ... These receptors, which we now call "antibodies," were called by Ehrlich "amboceptors" to emphasise their bifunctional binding ...
Immunologic disorder: Positive anti-Smith, anti-ds DNA, antiphospholipid antibody, or false positive serological test for ... Candidate gene loci implicated with SLE include multiple alleles from the HLA region, Fc-gamma receptor, and complement ... Simplest classification tree: SLE is diagnosed if a person has an immunologic disorder (anti-DNA antibody, anti-Smith antibody ... established a list of clinical and immunologic criteria that, in any combination, point to SLE. The criteria include symptoms ...
152.0 152.1 Lipton SA (2006). "Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond". Nat Rev Drug ... Solomon B (Juni 2007). "Clinical immunologic approaches for the treatment of Alzheimer's disease". Expert Opin Investig Drugs ... and GLP-1 receptor agonists". Ann. N. Y. Acad. Sci. 1035: 290-315. doi:10.1196/annals.1332.018 . PMID 15681814 . ...
Coakley, E., Petropoulos, C. J. and Whitcomb, J. M. (2005) Assessing chemokine co-receptor usage in HIV. Curr Opin Infect Dis. ... 1999) Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the ...
These cells have receptors that are similar to B cell receptors, and each cell recognizes only a few class II-peptide ... HLA antibodies are typically not naturally occurring, and with few exceptions are formed as a result of an immunologic ... Thus, serotyping became a way of crudely identifying HLA receptors and receptor isoforms. Over the years, serotyping antibodies ... The genes of the class II combine to form heterodimeric (αβ) protein receptors that are typically expressed on the surface of ...
Djeluje uglavnom kao antigenski receptor na B stanicama koje nisu bile izložene antigenom.[16] Pokazalo se je da aktiviraju ... "Immunologic Research 36 (1-3): 27-32. 10.1385/IR:36:1:27. https://www.ncbi.nlm.nih.gov/pubmed/17337763 ... Svaka Fc regija određenog izotipa antitijela može se vezati za svoj specifični Fc receptor (osim za IgD, koji je u suštini BCR ... dok se njegova Fc regija veže na Fc receptor ε. Interakcija alergen-IgE-FcRε posreduje alergijski prijenos signala kako bi se ...
Immunologic tests. *Tuberculosis. *Dermatologic procedures. Hidden categories: *Webarchive template wayback links. *All ...
Clapham PR, McKnight A. (2001). "HIV-1 receptors and cell tropism". 》Br Med Bull.》 58 (4): 43-59. PMID 11714623. doi:10.1093/ ... 1994). "Long-term HIV-1 infection without immunologic progression". 》AIDS》 8 (8): 1123-8. PMID 7986410. doi:10.1097/00002030- ...
Immunologic" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Immunologic" was a major or minor topic of ... "Receptors, Immunologic" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Receptors, Immunologic" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Receptors, Immunologic". ...
Although these receptors were first identified in the immune system, many have important functions elsewhere. ... Immunologic Receptors: Cell surface molecules on cells of the immune system that specifically bind surface molecules or ... Immunologic Receptors (Immunologic Receptor). Subscribe to New Research on Immunologic Receptors Cell surface molecules on ... Immunologic Receptor; Receptors, Immunologic; Immunological Receptors; Receptor, Immunologic; Receptors, Immunological. ...
Estrogen Receptor-Mediated, Nitric Oxide-Dependent Modulation of the Immunologic Barrier Function of the Endothelium. ... Estrogen Receptor-Mediated, Nitric Oxide-Dependent Modulation of the Immunologic Barrier Function of the Endothelium ... Estrogen Receptor-Mediated, Nitric Oxide-Dependent Modulation of the Immunologic Barrier Function of the Endothelium ... Estrogen Receptor-Mediated, Nitric Oxide-Dependent Modulation of the Immunologic Barrier Function of the Endothelium ...
1 receptor and its ligands (PD-L1, PD-L2) suppress the activity of T-lymphocyte … ... Immunologic Checkpoints in Cancer Therapy: Focus on the Programmed death-1 (PD-1) Receptor Pathway Pharmgenomics Pers Med. 2014 ... 1 receptor and its ligands (PD-L1, PD-L2) suppress the activity of T-lymphocytes. Advances in the understanding of immunology ...
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single ... Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single ... "Immunologic Self-tolerance Maintained By Activated T Cells Expressing IL-2 Receptor Alpha-chains (CD25). Breakdown of a Single ... Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single ...
Cell Surface Receptors and Recognition Factors. * Some Specific Aspects of Cell-Surface Recognition by Sipunculid Coelomocytes ...
Another problem that can arise with T cell receptor transfer is the generation of chimeric T cell receptors. Chimeric receptors ... A solution to this problem is the use of "hybrid T cell receptors" [54]. These T cell receptors contain murine constant regions ... inducible receptor-like protein 4-1BB). CD137 is expressed on CD4 and CD8 positive T cells upon activation and induces further ... 6. T-Cell Receptor Transfer. Another way of inducing tumor-specific immune responses is the direct transfer of tumor- ...
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide ... Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide ... Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed in ... Immunologic targeting of tumor-specific gene mutations may allow precise eradication of neoplastic cells without toxicity. ...
... due to the presence of immune receptors called Toll-Like Receptors (TLRs) that are expressed on the membranes of leukocytes ... Toll-like receptors[edit]. The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in ... "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune ... Takeda K, Akira S (January 2005). "Toll-like receptors in innate immunity". International Immunology. 17 (1): 1-14. doi:10.1093 ...
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3 ... Immunologic cell analysis.. For counting total splenocytes and splenic T-cells, splenic T-cells were magnetically separated ... Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 2008; 32( Suppl. 7): S8- S12. ... Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) 2006; 14( Suppl. 5): 208S- 212S. ...
Dissociation characteristics of endothelin receptor agonists and antagonists in cloned human type-B endothelin receptor. ... Immunologic procedures. For production of monoclonal antibodies (mAb), BALB/c mice were immunized with either HEK293 cells ... An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo . Proc ... Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma. Int J Dev Biol 2005;49:173 ...
Competitively blocks histamine from binding to H1 receptors. As a result of CNS penetration, diphenhydramine frequently causes ... Immunologic effectors. Class Summary. These agents are purified preparations of gamma globulin. Immunologic effectors are ... These agents decrease or prevent allergic symptoms caused by histamine receptors from mast cells. ... First-generation antihistamine that binds to H1 receptors in the CNS and the body. ...
TLR4 is a receptor for lipopolysaccharides of Gram-negative bacteria; and TLR9 is a receptor for bacterial DNA.32,33 Once the ... TLR-Toll-like receptor • Hib-Haemophilus influenzae type b • DTaP-diphtheria-tetanus-acellular pertussis • HPV-human papilloma ... Regulation of receptor-dependent activation of the innate immune response. J Infect Dis.2003;187 (suppl 2):S351- S355. ... Booster Vaccinations: Can Immunologic Memory Outpace Disease Pathogenesis? Message Subject (Your Name) has sent you a message ...
... contributing to the maintenance of immunologic self-tolerance. Their depletion or functional alteration leads to the ... Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses Annu Rev ... CD4+ regulatory T cells contribute to the maintenance of immunologic self-tolerance and negative control of various immune ... contributing to the maintenance of immunologic self-tolerance. Their depletion or functional alteration leads to the ...
Studies from Wonkwang University Have Provided New Information about Immunologic Receptors. Posted by: lncRNA Administrator in ... Genetics Iksan Immunologic Receptors Integrins Membrane Proteins South Korea 2014-02-03 lncRNA Administrator ...
Bone, Immunologic, and Virologic Effects of a Antiretroviral Regimen. The safety and scientific validity of this study is the ... A Phase 2b, Double-Blind, Placebo-Controlled, Exploratory Randomized Trial to Determine the Bone, Immunologic, Virologic, and ...
"T cell recognition of weak ligands: roles of signaling, receptor number, and affinity". Immunologic Research. 50 (1): 39-48. ... The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three dimeric signaling modules ... The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for ... TCR co-receptors[edit]. The signal from the T-cell complex is enhanced by simultaneous binding of the MHC molecules by a ...
CAR-T, or chimeric antigen receptor T-cells, a new form of cancer immunotherapy is advancing rapidly in the treatment of ... Immunologic cytotoxicity; Natural killer cell replacementsNACID 103CASI PharmaceuticalsIAntibody-dependent cell cytotoxicity; ... directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory ... Programmed cell death-1 receptor antagonists; T lymphocyte stimulantsIntravenousP BCMA 101Poseida TherapeuticsIIImmunologic ...
Receptors, Immunologic/metabolism*. Substance. *Receptors, Immunologic. LinkOut - more resources. Full Text Sources. *Elsevier ... In fact, recognition molecules of the innate immune system, such as toll-like receptors, might not only be implicated in host ...
Receptors, Immunologic. Grant support. *P01 AI106697/AI/NIAID NIH HHS/United States ... ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data.. Rosenfeld AM1 ...
... aka Pathogen Recognition Receptors, are cellular proteins expressed to identify Pathogen-Associated Molecular Patterns (PAMPs) ... Pattern Recognition Receptors "Pathogen Recognition Receptors (PRRs)" Pathogen Recognition Receptor (PRR). In our bodys Innate ... "Toll-Like Receptors (TLRs)" Toll Like Receptors (TLRs). In our bodys innate immune system, Toll-Like Receptors (TLRs) are a ... TLR7 gene encoding the toll-like receptor 7 *TLR8 gene (CD288 gene) encoding the toll-like receptor 8 (TLR8 receptor) *TLR9 ...
Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta ... Which immunologic mechanisms are involved in the etiology of ankylosing spondylitis (AS)?. Updated: Sep 03, 2019 ... Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 2008 Apr. 58(4):1020-5. [Medline] ... encoded search term (Which immunologic mechanisms are involved in the etiology of ankylosing spondylitis (AS)?) and Which ...
Degranulacija 1 - antigen; 2 - IgE; 3 - FcεRI receptor; 4 - medijatori (histamin, proteaze, hemokini, heparin); 5 - granule; 6 ... el); gren af biomedicin (da) Immunologico (it); Immunologique, Immunobiologie (fr); Inmunologia (eu); Immunològica, ... B7 family ligands and CD28 family receptors.JPG 664 × 609; 55 KB. ...
Immunologic receptors‎ (2 K, 40 D). *. ► Immunologic techniques‎ (3 K, 146 D) ... IgE FcεRI Receptor Signal Cascade.jpg 2.075 × 1.599; 1,29 MB. ... B7 family ligands and CD28 family receptors.JPG 664 × 609; 55 ... Degranulacija 1 - antigen; 2 - IgE; 3 - FcεRI receptor; 4 - medijatori (histamin, proteaze, hemokini, heparin); 5 - granule; 6 ... el); gren af biomedicin (da) Immunologico (it); Immunologique, Immunobiologie (fr); Inmunologia (eu); Immunològica, ...
Immunologic aspects of schistosomiasis. Annu Rev Med 1992; 43:209-218.. *CrossRef, ... Schistosoma TOR (trispanning orphan receptor), a novel, antigenic surface receptor of the blood-dwelling, Schistosoma parasite ... High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 1994; 367:183-186.. *CrossRef, ... Complement C2 receptor inhibitor trispanning and the beta-chain of C4 share a binding site for complement C2. J Immunol 2002; ...
Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves Disease and Graves Orbitopathy (IGF1RAbsGO). The ... Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves Disease and Graves Orbitopathy. ... Relationship between serum IGF-1R-Abs and anti-TSH receptor autoantibodies [ Time Frame: Baseline ]. The relationship between ... serum IGF-1R-Abs (both levels and prevalence) and anti-thyrotropic hormone-receptor serum autoantibodies ...
Immunologic Factors. Physiological Effects of Drugs. Antirheumatic Agents. Antineoplastic Agents, Alkylating. Alkylating Agents ... Biological: Epidermal growth factor receptor(EGFRv)III Chimeric antigen receptor (CAR) transduced PBL Drug: Aldesleukin Drug: ... Biological: Epidermal growth factor receptor(EGFRv)III Chimeric antigen receptor (CAR) transduced PBL Day 0: Cells will be ... Biological: Epidermal growth factor receptor(EGFRv)III Chimeric antigen receptor (CAR) transduced PBL Day 0: Cells will be ...
Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic ... and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic ... A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative ... Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of ...
receptor answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, ... immunologic receptor. A receptor on the surface of white blood cells that identifies the type of cell and links with monokines ... CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. The virus uses these receptors to gain entry into T ... accessory receptor. Any of the proteins on the surface of T lymphocytes that enhance the response of the T-cell receptor to ...
Z. Ma, E. Zhang, D. Yang, and M. Lu, "Contribution of Toll-like receptors to the control of hepatitis B virus infection by ... The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection. Ruilin Yang,1 Yao Xu,1 Zhifeng Dai,1 Xuhong Lin, ... Toll-like receptors (TLRs) are important protein molecules involved in innate immunity. Acting as a bridge connecting ... TLRs are the main pattern recognition receptors in the natural immune system and play a crucial role in the immune response [12 ...
  • The Laboratory of Clinical Immunology and Microbiology (LCIM) conducts clinical and basic science, and epidemiologic research into human immunologic, inflammatory, and infectious diseases. (nih.gov)
  • Therefore, an overview of novel immunological agents and combined therapeutic approaches is presented in this review, covering allogenic and autologous vaccine strategies, dendritic cell vaccination, strategies for adoptive immunotherapy and T cell receptor gene transfer, treatment with cytokines and monoclonal antibodies against the CTLA-4 antigen. (hindawi.com)
  • Second, antibodies were raised to the receptor, conjugated with monomethyl auristatin E, and tested for efficacy against melanoma tumor models generated from cell lines. (aacrjournals.org)
  • Immunologic effectors are derived from large pools of human plasma and comprise 4 subclasses of antibodies, approximating the distribution of human serum. (medscape.com)
  • Persistence of vaccine-induced antibodies usually goes well beyond the time when they should have decayed to undetectable levels because of ongoing "natural" boosting or other immunologic mechanisms. (aappublications.org)
  • They include tumor-associated antigen (TAA)-specific monoclonal antibodies (mAbs), T cell checkpoint blockade, and TAA-specific chimeric antigen receptors (CARs) T cell-based immunotherapy. (frontiersin.org)
  • Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. (wikipedia.org)
  • Antiphospholipid Antibodies Inhibit Trophoblast Toll-like Receptor and Inflammasome Negative Regulators. (annals.org)
  • Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor. (abcam.com)
  • 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. (abcam.com)
  • Preparation of monoclonal antibodies to the avian progesterone receptor. (abcam.com)
  • Anderson CL, Guyre PM, Whitin JC, Ryan DH, Looney RJ, Fanger MW: Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. (springer.com)
  • Guyre PM, Graziano RF, Vance BA, Morganelli PM, Fanger MW: Monoclonal antibodies that bind to distinct epitopes on FcγRI are able to trigger receptor function. (springer.com)
  • By using antibodies to LRP1 or receptor‐associated protein (RAP), an antagonist blocking LRP1 ligand binding, we found that CRT on target cells could interact in trans with LRP1 on a phagocyte and stimulate phagocytosis. (diva-portal.org)
  • An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens. (wikipedia.org)
  • Any of the proteins on the surface of T lymphocytes that enhance the response of the T-cell receptor to foreign antigens and stimulate signals from the receptor to the cytoplasm. (tabers.com)
  • Receptors, primarily on white blood cells, that bind with epitopes on foreign antigens, stimulating an immune response. (tabers.com)
  • Administration of anti-CTLA-4 Ab exacerbated autoimmune responses in a murine model of multiple sclerosis or insulin-dependent diabetes mellitus (IDDM [5-7]), enhanced tumor immunity ( 8 ), or prevented the induction of immunologic tolerance to concurrently administered non-self-antigens ( 9 ). (rupress.org)
  • The CR2-CD19-CD81 complex is often called the B cell co-receptor complex, because CR2 binds to opsonized antigens through attached C3d (or iC3b or C3dg) when the B-cell receptor binds antigen. (wikipedia.org)
  • For example, in an experimental treatment for chronic lymphocytic leukemia , researchers designed a virus to induce the expression on patient T cells of antibody receptors that identified and attached to antigens on malignant B cells and that activated the T cells, prompting them to destroy the B cells. (britannica.com)
  • Plasma levels of SARS-CoV-2 antigens were also measured, along with immunologic markers. (news-medical.net)
  • Although not invertebrates, the existence of an adaptive immune system in lampreys and hagfish based on variable molecules other than immunoglobulins indicates that a common function - that is, the production of diversified and clonally expressed receptors of antigens - may be achieved by means other than those in use in the immune system of jawed vertebrates. (biologists.org)
  • However, immune checkpoints such as cytotoxic T-lymphocyte-associated antigen (CTLA)-4 and programmed cell death (PD)-1 receptor and its ligands (PD-L1, PD-L2) suppress the activity of T-lymphocytes. (nih.gov)
  • The T-cell receptor , or TCR , is a molecule found on the surface of T cells , or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. (wikipedia.org)
  • CD4 receptors on T4 lymphocytes are the sites to which HIV binds, producing infection. (tabers.com)
  • Fc receptors are found on a number of cells in the immune system including phagocytes like macrophages and monocytes, granulocytes like neutrophils and eosinophils, and lymphocytes of the innate immune system (natural killer cells) or adaptive immune system (e.g. (wikipedia.org)
  • By expressing in appropriate time and location, these pathways have different regulatory functions through independent receptors or on different subsets of lymphocytes. (biomedsearch.com)
  • The results showed that PMBL exerts a therapeutic and preventing effect in acute and recurrent infections of the upper respiratory tract and that this effect correlated with the activation and enhancement of both IgM memory B lymphocytes (CD24+/CD27+ cells) and IL2 receptor-expressing lymphocytes (CD25+ cells) involved either in humoral or cellular immunity. (biomedsearch.com)
  • Immunologically, atypical lymphocytes stain positively for CD3 and CD8, with clonal rearrangement of the T-cell receptor gene documented. (medscape.com)
  • Acute manipulations of insulin in vivo regulate the display of insulin receptors induced on activated T lymphocytes after presentation of alloantigen. (diabetesjournals.org)
  • It is concluded that those immunologic activities of lymphocytes that can be modulated by insulin are affected by regulation of insulin-receptor display on activated lymphocytes. (diabetesjournals.org)
  • Immunologic responses were monitored by tetramer staining of circulating CD8 + lymphocytes and delayed-type hypersensitivity tests. (aacrjournals.org)
  • Lamprey lymphocytes possess variable lymphocyte receptors (VLRs) containing multiple leucine-rich repeats (LRRs). (biologists.org)
  • Naturally occurring CD4+ regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic self-tolerance. (nih.gov)
  • Based on recent advances in our understanding of the cellular and molecular basis of this T cell-mediated immune regulation, this review discusses how naturally arising CD25+CD4+ regulatory T cells contribute to the maintenance of immunologic self-tolerance and negative control of various immune responses, and how they can be exploited to prevent and treat autoimmune disease, allergy, cancer, and chronic infection, or establish donor-specific transplantation tolerance. (nih.gov)
  • Naturally arising CD4 + regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. (jci.org)
  • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. (duke.edu)
  • Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed in normal tissues but widely expressed in glioblastoma multiforme (GBM) and other neoplasms.A phase II, multicenter trial was undertaken to assess the immunogenicity of an EGFRvIII-targeted peptide vaccine and to estimate the progression-free survival (PFS) and overall survival (OS) of vaccinated patients with newly diagnosed EGFRvIII-expressing GBM with minimal residual disease. (duke.edu)
  • In this protocol, we are modifying the patient's white blood cells with a retrovirus that has the gene for epidermal growth factor receptor (EGFR) vIII incorporated in the retrovirus. (clinicaltrials.gov)
  • Epidermal growth factor receptor (EGFR). (clinicaltrials.gov)
  • Patients with advanced non-small cell lung cancer (NSCLC) harboring mutations of the epidermal growth factor receptor ( EGFR ) gene respond well to the EGFR tyrosine kinase inhibitor (TKI) gefitinib. (springer.com)
  • epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors (TKIs) have been a new paradigm of lung cancer treatment. (springer.com)
  • In our body's Innate Immune System Endocytic PRRs recognize carbohydrates and include mannose receptors of macrophages, glucan receptors present on all phagocytes and scavenger receptors that recognize charged ligands, are found on all phagocytes and mediate removal of apoptotic cells. (wellnessadvocate.com)
  • The virus uses these receptors to gain entry into T cells, macrophages, and other CD4 + cells. (tabers.com)
  • A receptor on phagocytes (neutrophils, monocytes, and macrophages) that binds Fc fragments of immunoglobulins G and E. (tabers.com)
  • The classes of FcR's are also distinguished by the cells that express them (macrophages, granulocytes, natural killer cells, T and B cells) and the signalling properties of each receptor. (wikipedia.org)
  • An example of the latter mechanism is that mediated by the cell surface glycoprotein CD47, which by binding to the inhibitory receptor Signal Regulatory Protein alpha (SIRPα) on macrophages, is known to inhibit phagocytosis of viable host cells. (diva-portal.org)
  • Fas ligand (FasL) is a membrane protein capable of inducing apoptosis in cells bearing its receptor, Fas, primarily cells of the immune system. (ahajournals.org)
  • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). (unboundmedicine.com)
  • Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules. (unboundmedicine.com)
  • Immunologic targeting of tumor-specific gene mutations may allow precise eradication of neoplastic cells without toxicity. (duke.edu)
  • Accordingly, we have targeted the endothelin B receptor (EDNBR) on the basis of its overexpression on human melanoma cells. (aacrjournals.org)
  • The receptors for endothelins were cloned shortly thereafter ( 4, 5 ) and their expression in various cell types, including melanocytes and melanoma cells, pointed to functions independent of their role in endothelium. (aacrjournals.org)
  • It is now well recognized that the endothelin B receptor (EDNBR) is critical for the faithful derivation of melanocytic cells emanating from the neural crest during embryonic development ( 6, 7 ). (aacrjournals.org)
  • These agents decrease or prevent allergic symptoms caused by histamine receptors from mast cells. (medscape.com)
  • T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate receptor, formed by variable gamma (γ) and delta (δ) chains, referred as γδ T cells. (wikipedia.org)
  • In our body's Innate Immune System cells, Pathogen Recognition Receptors (PRRs) (aka Pattern Recognition Receptors) are proteins expressed to identify Pathogen-Associated Molecular Patterns (PAMPs) , which are associated with microbial pathogens or cellular stress, as well as DAMPs, (damage-associated molecular patterns). (wellnessadvocate.com)
  • In our body's Innate Immune System cells, Pattern Recognition Receptors (PRRs) (aka pathogen recognition receptors) functionally may be divided into endocytic PRRS or signaling PRRS . (wellnessadvocate.com)
  • In our body's Innate Immune System cells, Signaling PRRs are a functional family of Pathogen Recognition Receptors (PRRs) (aka Pattern Recognition Receptors) that include membrane-bound Toll-Like Receptors (TLRs) and cytoplasmic NOD-Like Receptors (NLRs) . (wellnessadvocate.com)
  • In our body's Innate Immune System cells, Endocytic PRRs are a functional family of Pathogen Recognition Receptors (PRRs) (aka Pattern Recognition Receptors) that promote the attachment, engulfment and destruction of microorganisms by phagocytes, without relaying an intracellular signal. (wellnessadvocate.com)
  • For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. (frontiersin.org)
  • In 1989, Gross and colleagues introduced the concept of engineering T cells with chimeric receptors capable of overcoming the major histocompatibility complex restriction, laying the groundwork to generate a powerful tool for targeted cancer immunotherapy ( 1 ). (frontiersin.org)
  • The chimeric antigen receptors (CARs) are molecules capable of redirecting cytotoxic T cells (CTLs) against a tumor-associated antigen (TAA) expressed on the surface of malignant cells. (frontiersin.org)
  • Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection. (wikipedia.org)
  • Leptin receptor-deficient ( db/db ) mice display marked increase in the number and suppressive function of Treg cells. (ahajournals.org)
  • 11-13 However, whether defective leptin/leptin receptor signaling in Treg cells may affect their suppressive response and alter the development of immunoinflammatory diseases is still unknown. (ahajournals.org)
  • When the CD25 + CD4 + T cells are stimulated via the T cell receptor in vitro, they potently suppress antigen-specific and polyclonal activation and proliferation of other T cells, including CTLA-4-deficient T cells, and blockade of CTLA-4 abrogates the suppression. (rupress.org)
  • There is accumulating evidence that, in addition to clonal deletion or anergy, T cell-mediated dominant control of self-reactive T cells represents one mechanism for maintaining immunologic self-tolerance ( 11 ). (rupress.org)
  • Baars PA, Ribeiro Do Couto LM, Leusen JH, Hooibrink B, Kuijpers TW, Lens SM, van Lier RA (2001) Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8 + CD45RA + CD27 − human T cells. (springermedizin.de)
  • After completing their maturation, the immigrated DC prime hapten-specific naive T cells in an IL-12-dependent manner ( 5 ), giving rise to allergen-specific CD8 + T cells which express skin-specific homing receptors ( 6 ). (rupress.org)
  • Research includes studies of cytokines and chemokines in HIV replication, the latent reservoir of HIV-infected cells in AIDS and its implications for antiretroviral therapy, and immunologic approaches to the treatment of HIV infection. (nih.gov)
  • B cells express CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation Complement receptor 2 interacts with CD19, and, on mature B cells, forms a complex with CD81 (TAPA-1). (wikipedia.org)
  • 1976) found complete overlapping of EBV receptors and C3 receptors on human B cells. (wikipedia.org)
  • The majority, if not all, of such naturally occurring CD4 + T R cells constitutively express CD25 (IL-2 receptor α chain) in the physiologic state. (jci.org)
  • HIV infection leads to a complex immunologic disorder combining a progressive decrease in CD4 T cells and a chronic activation of T and B cells, associated with increased serum concentrations of β2 microglobulin and other immune activation markers. (biomedcentral.com)
  • In these processes, specific binding among cells mediated by recognition of carbohydrates by protein receptors, lectins, is crucial. (europa.eu)
  • PKCa and PKCd activation regulates transcriptional activity and degradation of progesterone receptor in human astrocytoma cells. (abcam.com)
  • Progesterone receptor concentration differences in the chick oviduct cells and apparent down-regulation by ligand. (abcam.com)
  • Through interaction with antibody, IgG Fc receptors provide an interface between specific humoral immunity and FcγR-bearing host cells. (springer.com)
  • Perussia B, Dayton ET, Lazarus R, Fanning V, Trinchieri G: Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. (springer.com)
  • Looney RJ, Abraham GN, Anderson CL: Human monocytes and U937 cells bear two distinct Fc receptors for IgG. (springer.com)
  • A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of 'missing-self' recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. (elifesciences.org)
  • Phagocytosis of apoptotic cells is mediated by many phagocytic receptors, soluble bridging molecules, and pro-phagocytic ligands on the surface of apoptotic cells. (diva-portal.org)
  • The endoplasmatic protein calreticulin (CRT), in conjunction with Low density lipoprotein Receptorrelated Protein 1 (LRP1) on the phagocyte, can act as a receptor for collectin family members and mediate uptake of apoptotic cells. (diva-portal.org)
  • In other cases a chemotherapeutic agent attached to an antibody destroys cancer cells by interacting with receptors on their surfaces that trigger apoptosis. (britannica.com)
  • A phase I/II trial was conducted to evaluate clinical and immunologic responses after intralymphatic and intranodal injections of mature dendritic cells. (aacrjournals.org)
  • The cells were matured overnight with Ribomunyl, a toll-like receptor ligand, and IFN-γ, which ensured the production of high levels of interleukin-12p70. (aacrjournals.org)
  • Injections into the lymphatic system of mature peptide-loaded dendritic cells with potential TH1 polarization capacities did not result in marked clinical results, despite immunologic responses in some patients. (aacrjournals.org)
  • Although activation of natural killer (NK) cytotoxicity is generally inhibited by target major histocompatibility complex (MHC) class I expression, subtle features of NK allorecognition suggest that NK cells possess receptors that are activated by target MHC I. The mouse Ly-49D receptor has been shown to activate NK cytotoxicity, although recognition of MHC class I has not been demonstrated previously. (nih.gov)
  • These experiments show that the activating receptor Ly-49D specifically interacts with the MHC I antigen, H-2Dd, demonstrating the existence of alloactivating receptors on murine NK cells. (nih.gov)
  • The immune system discriminates between self and non-self, maintaining immunologic self-tolerance (i.e., unresponsiveness to self-constituents). (jci.org)
  • Fanger MW, Shen L, Graziano RF, Guyre PM: Cytotoxicity mediated by human Fc receptors for IgG. (springer.com)
  • In the absence of further reduction of insulin-receptor membrane display, neither the mixed-lymphocyte culture nor lymphocyte-mediated cytotoxicity reaction was affected. (diabetesjournals.org)
  • CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. (cancerindex.org)
  • Of the two best understood pathways of apoptosis, the extrinsic and intrinsic (mitochondrial) pathways, the former is induced by the ligation of death receptors, a subset of the TNF receptor (TNFR) superfamily. (bireme.br)
  • Programmed Cell Death (Apoptosis) and the Immunologic Derangements of Critical Illness. (indigo.ca)
  • The immunologic abnormalities resolved when the polyradiculoneuritis and lipoid nephrosis remitted. (annals.org)
  • Pulmonary function and immunologic abnormalities in miliary tuberculosis. (semanticscholar.org)
  • Du X. et al "Three novel mammalian toll-like receptors: gene structure, expression, and evolution" Eur Cytokine Netw. (wellnessadvocate.com)
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. (cancerindex.org)
  • Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein receptor (LDLR) gene. (tudelft.nl)
  • Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein-Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein that in humans is encoded by the CR2 gene. (wikipedia.org)
  • primate complement receptor 1, which recapitulates many of the structural domains and presumed functions of Cr2-derived CR1 in subprimates, is encoded by a distinct CR1 gene (apparently derived from the gene Crry of subprimates). (wikipedia.org)
  • Methods and Results- In this study, we report that leptin-deficiency ( ob/ob ) in low-density lipoprotein receptor knockout ( ldlr −/− ) mice induces an unexpected 2.2- to 6-fold reduction in atherosclerotic lesion development, compared with ldlr −/− mice having similar total cholesterol levels. (ahajournals.org)
  • The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. (tabers.com)
  • DK-PGD(2) (10 microg x ml(-1)) -induced airway eosinophilia was inhibited when animals were treated with the CRTH2 receptor antagonist ramatroban . (curehunter.com)
  • Mast cell degranulation was also blocked by preincubation with antiserum against CRH and was partially inhibited by a CRH type-1 receptor selective antagonist. (aspetjournals.org)
  • Sensory neuropeptides did not appear to influence this effect, but a nonpeptide neurotensin receptor antagonist blocked stress-induced cardiac mast cell degranulation. (aspetjournals.org)
  • All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (marked) microbes. (wikipedia.org)
  • It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family. (wikipedia.org)
  • With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily. (wikipedia.org)
  • Two types of FcεR are known: the high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like domains). (wikipedia.org)
  • We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. (cdc.gov)
  • Girard MT, Hjaltadottir S, Fejes-Toth AN, Guyre PM: Glucocorticoids enhance the gamma-interferon augmentation of human monocyte immunoglobulin G Fc receptor expression. (springer.com)
  • Hibbs ML, Bonadonna L, Scott BM, McKenzie IFC: Molecular cloning of a human immunoglobulin G Fc receptor. (springer.com)
  • The T-cell receptor complex with TCR-α and TCR-β chains, CD3 and ζ-chain accessory molecules. (wikipedia.org)
  • When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, that is, a series of biochemical events mediated by associated enzymes, co-receptors, specialized adaptor molecules, and activated or released transcription factors. (wikipedia.org)
  • In fact, recognition molecules of the innate immune system, such as toll-like receptors, might not only be implicated in host defense but also in the pathogenesis of the disease. (nih.gov)
  • In our body's innate immune system , Toll-Like Receptors (TLRs) recognize structurally conserved molecules derived from microbes, soon after these microbes have entered the body proper, which activate immune cell responses. (wellnessadvocate.com)
  • More than 100 receptor molecules have been identified. (tabers.com)
  • This property allows FcγRI to bind a sole IgG molecule (or monomer), but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. (wikipedia.org)
  • In addition to presenting peptides that activate antigen-specific CTL, MHC-I molecules also serve as ligands for NK cell inhibitory receptors. (elifesciences.org)
  • When conjugated with monomethyl auristatin E, the antibody-drug conjugate (ADC) showed remarkable efficacy against human melanoma cell lines and xenograft tumor models that was commensurate with levels of receptor expression. (aacrjournals.org)
  • This receptor is particularly attractive as a target for antibody-drug conjugate (ADC) therapy because of its minimal expression on normal tissue, its cell-surface localization, and rapid endocytosis. (aacrjournals.org)
  • There are several different types of Fc receptors (abbreviated FcR), which are classified based on the type of antibody that they recognize. (wikipedia.org)
  • For example, those that bind the most common class of antibody, IgG, are called Fc-gamma receptors (FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR). (wikipedia.org)
  • Another FcR is expressed on multiple cell types and is similar in structure to MHC class I. This receptor also binds IgG and is involved in preservation of this antibody. (wikipedia.org)
  • Another receptor can also bind IgA, although it has higher affinity for another antibody called IgM. (wikipedia.org)
  • As expected, anti- Ly-49D monoclonal antibody 12A8 specifically stimulated redirected lysis of the Fc receptor- bearing rat target YB2/0 by RNK.mLy-49D transfectants. (nih.gov)
  • We have constructed a retroviral vector that contains a chimeric antigen receptor (CAR) that recognizes the EGFRvIII tumor antigen, which can be used to mediate genetic transfer of this CAR with high efficiency without the need to perform any selection. (clinicaltrials.gov)
  • Nelms B, Dalomba NF, Lencer W. A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. (childrenshospital.org)
  • One such strategy is the selective upregulation of surface expression of HLA-E in humans and Qa-1 in mice, the non-classical MHC-I proteins that serve as ligands for the NK cell inhibitory receptor CD94/NKG2A. (elifesciences.org)
  • This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. (cancerindex.org)
  • Integral in the regulation and initiation of death receptor-mediated activation of programmed cell death is the aspartate-specific cysteine protease (caspase)-8. (bireme.br)
  • Soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. (semanticscholar.org)
  • Collectively, these findings reveal an innovative NK evasion strategy wherein RHVP encodes a modified Qa-1 mimic refractory to MHC-I sabotage and capable of specifically engaging inhibitory receptors to circumvent NK activation. (elifesciences.org)
  • Many aspects of receptor activation and signaling can be investigated using genetically encoded luminescent fusion proteins. (bioportfolio.com)
  • Their main goal is to better understand basic mechanisms that regulate the pathology of food allergies and are studying general issues of the molecular biology of immune recognition receptors and IgE-mediated activation of the immune system. (childrenshospital.org)
  • We thus designed in 1992 a pilot study to evaluate the clinical, immunologic and virologic effects of PDN. (biomedcentral.com)
  • CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. (tabers.com)
  • Using NanoLuc and bioluminescence resonance energy transfer we demonstrate fluorescent ligand binding at genome-edited chemokine receptors. (bioportfolio.com)
  • Przełom nastąpił w 1995 roku, kiedy opublikowana została praca Shimona Sakaguchi i współpracowników wskazująca, że za efekt supresorowy odpowiadają limfocyty T CD4 + wykazujące wysoką ekspresję białka CD25 , stanowiącego receptor dla IL-2 [19] . (wikipedia.org)
  • Unkeless JC, Scigliano E, Freedman VH: Structure and function of human and murine receptors for IgG. (springer.com)
  • In our body's innate immune system , Toll-Like Receptors (TLRs) are a class of germline-encoded type 1 transmembrane receptor proteins that play a key role, as a single, membrane-spanning, non-catalytic signaling pathogen recognition receptor (PRR) . (wellnessadvocate.com)
  • Because exposure to contact allergens always takes place in the presence of microbial skin flora, we investigated the potential role of Toll-like receptors (TLRs) in the induction of CHS. (rupress.org)
  • Elevated interleukin-2 receptor level in patients with active pulmonary tuberculosis and the changes following anti-tuberculosis chemotherapy. (semanticscholar.org)
  • A case of tuberculous peritonitis in a hemodialysis patient with high serum soluble interleukin-2 receptor and CA-125 levels. (semanticscholar.org)
  • It is, therefore, of utmost importance to appropriately screen all patients for latent TB infection prior to initiating any immunologic therapy. (nih.gov)
  • Delaying immunologic therapy until latent TB infection prophylaxis is completed is preferable. (nih.gov)
  • This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection. (hindawi.com)
  • First-generation antihistamine that binds to H1 receptors in the CNS and the body. (medscape.com)
  • Laboratory of Immunogenetics (LIG) research focuses on the cellular and molecular mechanisms underlying the signaling functions of immune cell receptors. (nih.gov)
  • This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant immunologic self-tolerance. (rupress.org)
  • ABBR: CCR Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. (tabers.com)
  • One such candidate, the endothelin B receptor (EDNBR), was first analyzed for a functional contribution to tumor growth by conditional induction of shRNA. (aacrjournals.org)
  • Conditional knockdown of the receptor in tumor xenograft models resulted in only a modest impact on tumor growth. (aacrjournals.org)
  • Tumor Necrosis Factor Receptors in Systemic Inflammation. (indigo.ca)
  • Expression of functional interleukin 2 receptors by peripheral blood monocytes from patients with active pulmonary tuberculosis. (semanticscholar.org)
  • Lep ob/ob mice) or the leptin receptor (LepR) (e.g. (diabetesjournals.org)
  • Here we report the identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of T reg and T H 17 cell differentiation in mice. (nature.com)
  • It has previously been reported that mice lacking the VLDL receptor (VLDLR-/-) exhibit normal plasma lipid levels and a modest decrease in adipose tissue mass. (tudelft.nl)
  • The effects of receptor antagonists on the AHH induction activity of 2,3,7,8-TCDD in C57BW6 and DBA/2 mice: 1,3,6,8-Tetrachlorodibenzofuran. (cdc.gov)
  • Methods and Results- LDL-receptor-deficient mice were fed a high-cholesterol diet for 8 weeks to build up aortic sinus atherosclerotic lesions and then were fed a normal diet with or without 5% EPA for 4 weeks. (ahajournals.org)
  • Low-density lipoprotein receptor knockout (LDLR −/− ) mice were kept in a specific pathogen-free animal facility at Kobe University Institute. (ahajournals.org)
  • Conclusions- These results identify a critical role for leptin/leptin receptor pathway in the modulation of the regulatory immune response in atherosclerosis, and suggest that alteration in regulatory immunity may predispose obese individuals to atherosclerosis. (ahajournals.org)
  • 105, 521-532) in which apoE prevents the inhibitory action of the low density lipoprotein receptor (LDLr) by binding to it. (tudelft.nl)
  • Ectodomain Shedding of Receptor Activator of NF-KB Ligand. (springer.com)
  • We demonstrate here that calreticulin acts as a second general recognition ligand by binding and activating LDL-receptor-related protein (LRP) on the engulfing cell. (diva-portal.org)
  • This study supports the hypothesis that insulin-directed immunologic activity is regulated at the site of receptor display rather than at the locus of regulation of the ligand itself. (diabetesjournals.org)
  • To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK.mLy-49D). (nih.gov)
  • CUS may be produced by nonimmunologic (irritant) or immunologic (allergic) mechanisms. (renalandurologynews.com)
  • As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. (wikipedia.org)
  • Elevated serum levels of soluble interleukin-2 receptors in lung cancer and the effect of surgery. (semanticscholar.org)
  • Serum concentration of soluble interleukin 2 receptors in asthma. (semanticscholar.org)
  • Which immunologic mechanisms are involved in the etiology of ankylosing spondylitis (AS)? (medscape.com)
  • Protein contact dermatitis (PCD) represents a subset of immunologic mechanisms, in which repeated exposure to the urticariant causes the urticarial lesions to transform into dermatitis (eczema). (renalandurologynews.com)
  • This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity. (rupress.org)
  • Ligation of these death receptors can also induce necroptosis. (bireme.br)
  • Immunologic Regulation Of Bone Development. (springer.com)
  • This study explored the immunobiological consequences of regulation of insulin-receptor display by acute manipulations of insulin achieved during the hyperinsulinemic-euglycemic clamp in healthy normal individuals and obese subjects. (diabetesjournals.org)
  • Therefore, receptor regulation is not effete but carries significant immunologic consequence. (diabetesjournals.org)
  • Interaction with estrogen receptors as treatment of arthritis and osteoporosis. (springer.com)
  • Hyperinsulinemia achieved by the clamp in seven obese subjects did not alter the synthesis of insulin receptors on cell membrane after presentation of alloantigen. (diabetesjournals.org)
  • NK cell activity against viral-infected targets is balanced by integrated signals from inhibitory and activating receptors. (elifesciences.org)
  • A site in autonomic nerve pathways responsive to the adrenergic agents norepinephrine and epinephrine In general, alpha-1 receptors produce excitatory responses, and alpha-2 receptors produce inhibitory responses. (tabers.com)
  • In general, beta-1 receptors produce excitatory responses, and beta-2 receptors produce inhibitory responses. (tabers.com)
  • Like other type I cytokine receptors ( 11 ), LepRb (which is required for physiologic leptin action) contains no intrinsic enzymatic activity, but associates with and activates the Janus kinase 2 (Jak2) tyrosine kinase to mediate leptin signaling. (diabetesjournals.org)
  • Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. (cancerindex.org)
  • protein -coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling. (bioportfolio.com)
  • Pancreatic carcinomas express high levels of urokinase-type plasminogen activator (uPA) and its receptor (uPAR), both of which mediate cell migration and invasion. (aacrjournals.org)
  • The urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) system has also been shown to mediate cell migration and invasion. (aacrjournals.org)
  • In vitro, estradiol is shown to regulate FasL expression at the transcriptional level via an estrogen receptor-mediated, NO-dependent mechanism. (ahajournals.org)
  • Conclusions Estradiol transcriptionally regulates endothelial FasL expression by a mechanism involving at least one of the estrogen receptors. (ahajournals.org)
  • Petroni KC, Shen L, Guyre PM: Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-γ and glucocorticoids. (springer.com)
  • Recent changes in anaphylaxis definitions require a review of the immunologic and nonimmunologic biochemical pathways of anaphylaxis. (intechopen.com)
  • Recently, research suggested that this receptor plays a role in the homeostasis of IgG serum levels. (wikipedia.org)
  • Receptors, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)