A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.
A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.
A fibroblast growth factor that is a mitogen for KERATINOCYTES. It activates FIBROBLAST GROWTH FACTOR RECEPTOR 2B and is involved in LUNG and limb development.
A fibroblast growth factor receptor that is mainly expressed in LUNG; KIDNEY; PANCREAS; and SPLEEN. It also plays an important role in SKELETAL MUSCLE development and can contribute to NEOPLASTIC CELL TRANSFORMATION.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
A fibroblast growth factor that was originally identified as a mitogen for GLIAL CELLS. It is expressed primarily in NEURONS.
A HEPARIN binding fibroblast growth factor that may play a role in LIMB BUDS development.
A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Signal molecules that are involved in the control of cell growth and differentiation.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A fibroblast growth factor that preferentially activates FIBROBLAST GROWTH FACTOR RECEPTOR 4. It was initially identified as an androgen-induced growth factor and plays a role in regulating growth of human BREAST NEOPLASMS and PROSTATIC NEOPLASMS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
A fibroblast growth factor that may play a role in regulation of HAIR FOLLICLE phenotype. Spontaneous mutation of the gene for this protein results in a strain of MICE with abnormally long hair, referred to as angora mice.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
Established cell cultures that have the potential to propagate indefinitely.
A fibroblast growth factor that is expressed primarily during development.
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A fibroblast growth factor that was initially identified based on its sequence similarity to FIBROBLAST GROWTH FACTOR 4. It is found in MYOBLASTS and plays an important role in MUSCLE DEVELOPMENT.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The most divergent of the known fibroblast growth factor receptors. It does not contain an intracellular TYROSINE KINASE domain and has been shown to interact with FIBROBLAST GROWTH FACTOR 2. Fibroblast growth factor receptor 5 is found primarily in skeletal tissue.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Proteins prepared by recombinant DNA technology.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.

Increased expression of fibroblast growth factor 8 in human breast cancer. (1/1714)

Fibroblast growth factor 8 (FGF8) is an important developmental protein which is oncogenic and able to cooperate with wnt-1 to produce mouse mammary carcinoma. The level of expression of FGF8 mRNA was measured in 68 breast cancers and 24 non-malignant breast tissues. Elevated levels of FGF8 mRNA were found in malignant compared to non-malignant breast tissues with significantly more malignant tissues expressing FGF8 (P=0.019) at significantly higher levels (P=0.031). In situ hybridization of breast cancer tissues and analysis of purified populations of normal epithelial cells and breast cancer cell lines showed that malignant epithelial cells expressed FGF8 mRNA at high levels compared to non-malignant epithelial and myoepithelial cells and fibroblasts. Although two of the receptors which FGF8 binds to (FGFR2-IIIc, FGFR3-IIIc) are not expressed in breast cancer cells, an autocrine activation loop is possible since expression of fibroblast growth factor receptor (FGFR) 4 and FGFR1 are retained in malignant epithelial cells. This is the first member of the FGF family to have increased expression in breast cancer and a potential autocrine role in its progression.  (+info)

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. (2/1714)

We have identified a novel fibroblast growth factor receptor 3 (FGFR3) missense mutation in four unrelated individuals with skeletal dysplasia that approaches the severity observed in thanatophoric dysplasia type I (TD1). However, three of the four individuals developed extensive areas of acanthosis nigricans beginning in early childhood, suffer from severe neurological impairments, and have survived past infancy without prolonged life-support measures. The FGFR3 mutation (A1949T: Lys650Met) occurs at the nucleotide adjacent to the TD type II (TD2) mutation (A1948G: Lys650Glu) and results in a different amino acid substitution at a highly conserved codon in the kinase domain activation loop. Transient transfection studies with FGFR3 mutant constructs show that the Lys650Met mutation causes a dramatic increase in constitutive receptor kinase activity, approximately three times greater than that observed with the Lys650Glu mutation. We refer to the phenotype caused by the Lys650Met mutation as "severe achondroplasia with developmental delay and acanthosis nigricans" (SADDAN) because it differs significantly from the phenotypes of other known FGFR3 mutations.  (+info)

Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (3/1714)

Recent reports indicate that a gain-of-function mutation in fibroblast growth factor receptor 3 (FGFR-3) inhibits cell growth in the cartilaginous growth plates. These results suggest that FGFR-3 may be the receptor transducing growth inhibitory signals. Using reverse transcription-PCR we examined seven papillary thyroid carcinomas to determine FGFR-3 expression. Six out of the seven papillary carcinomas expressed FGFR-3. To clarify the role of FGFR-3 in thyroid carcinoma, FGFR-3 was overexpressed in an established human papillary thyroid carcinoma cell line. High levels of FGFR-3 protein were identified in cells stably transfected with the vector containing FGFR-3 cDNA. The specific binding of 125I-FGF-2 of these cells was threefold higher than that of control cells. Growth rates of cells overexpressing FGFR-3 were similar to those of control cells. However, cells overexpressing FGFR-3 continued to grow beyond the density at which control cells stopped proliferating. These results suggest that FGFR-3 in thyroid carcinoma is not involved strongly in the cell proliferation mechanism but may contribute to the malignant extension of some of the carcinomas by modifying cell contact signaling.  (+info)

Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. (4/1714)

Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem cells emerge later in development in a temporally and spatially specific manner. By separately blocking EGF and FGF2 signaling, we also show that EGF alone and FGF2 alone can independently elicit neural stem cell proliferation and at relatively high cell densities separate cell nonautonomous effects can substantially enhance the mitogen-induced proliferation. At lower cell densities, neural stem cell proliferation is additive in the presence of EGF and FGF2 combined, revealing two different stem cell populations. However, both FGF-responsive and EGF-responsive neural stem cells retain their self-renewal and multilineage potential, regardless of growth factor conditions. These results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone.  (+info)

Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. (5/1714)

Deletions and amplifications are frequent alterations of the short arm of chromosome 8 associated with various types of cancers, including breast cancers. This indicates the likely presence of tumor suppressor genes and oncogenes. In the present study, we have used the expressed sequence tag (EST) map of 8p11-21 to assemble a set of available cDNAs representing genes from this region. DNA arrays were prepared for expression analysis and search for genes potentially involved in breast cancer. Underexpresion in tumoral breast cells (versus normal breast) was observed for 15 transcripts. Among these, the Frizzled-related gene FRP1/FRZB, was turned off in 78% of breast carcinomas, suggesting that the lack of its product may be associated with malignant transformation. Overexpression in tumoral breast cells was observed for 13 genes. The FGFR1 gene, that encodes a tyrosine kinase receptor for members of the fibroblast growth factor family, was identified as a good candidate for one amplification unit. Taken together, our results demonstrate that such a strategy can rapidly identify genes with an altered pattern of expression and provide candidate genes for malignancies.  (+info)

Mutations within or upstream of the basic helix-loop-helix domain of the TWIST gene are specific to Saethre-Chotzen syndrome. (6/1714)

Saethre-Chotzen syndrome (ACS III) is an autosomal dominant craniosynostosis syndrome recently ascribed to mutations in the TWIST gene, a basic helix-loop-helix (b-HLH) transcription factor regulating head mesenchyme cell development during cranial neural tube formation in mouse. Studying a series of 22 unrelated ACS III patients, we have found TWIST mutations in 16/22 cases. Interestingly, these mutations consistently involved the b-HLH domain of the protein. Indeed, mutant genotypes included frameshift deletions/insertions, nonsense and missense mutations, either truncating or disrupting the b-HLH motif of the protein. This observation gives additional support to the view that most ACS III cases result from loss-of-function mutations at the TWIST locus. The P250R recurrent FGFR 3 mutation was found in 2/22 cases presenting mild clinical manifestations of the disease but 4/22 cases failed to harbour TWIST or FGFR 3 mutations. Clinical re-examination of patients carrying TWIST mutations failed to reveal correlations between the mutant genotype and severity of the phenotype. Finally, since no TWIST mutations were detected in 40 cases of isolated coronal craniosynostosis, the present study suggests that TWIST mutations are specific to Saethre-Chotzen syndrome.  (+info)

The Xenopus Ets transcription factor XER81 is a target of the FGF signaling pathway. (7/1714)

We report the cloning of a cDNA encoding a Xenopus laevis Ets-type transcription factor. This new Xenopus gene belongs to the PEA3 subfamily of Ets proteins and shows the highest degree of sequence similarity to the mouse and human ER81 genes. The Xenopus ER81 gene (XER81) is transcribed in the embryo after mid blastula transition (MBT) and three transcripts of 3, 4 and 6 kb are detected throughout embryogenesis. XER81 mRNA is localized in the animal pole of the late blastula stage and higher levels of XER81 transcripts are detected in the marginal zone at the onset of gastrulation. In later embryogenesis XER81 transcripts are found in neural crest cells, eyes, otic vesicles and pronephros. The transcription of XER81 can be stimulated by bFGF and eFGF in animal and vegetal cap explants. Expression of the dominant negative FGF receptor mutant in animal caps and embryos blocks XER81 transcription, arguing that the expression of this Ets gene requires active FGF signaling. The spatial overlap of eFGF and XER81 expression domains supports the idea that XER81 transcription could be a marker for regions with active FGF signaling in the embryo.  (+info)

Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex. (8/1714)

Fibroblast growth factor (FGF) family plays key roles in development, wound healing, and angiogenesis. Understanding of the molecular nature of interactions of FGFs with their receptors (FGFRs) has been seriously limited by the absence of structural information on FGFR or FGF-FGFR complex. In this study, based on an exhaustive analysis of the primary sequences of the FGF family, we determined that the residues that constitute the primary receptor-binding site of FGF-2 are conserved throughout the FGF family, whereas those of the secondary receptor binding site of FGF-2 are not. We propose that the FGF-FGFR interaction mediated by the 'conserved' primary site interactions is likely to be similar if not identical for the entire FGF family, whereas the 'variable' secondary sites, on both FGF as well as FGFR mediates specificity of a given FGF to a given FGFR isoform. Furthermore, as the pro-inflammatory cytokine interleukin 1 (IL-1) and FGF-2 share the same structural scaffold, we find that the spatial orientation of the primary receptor-binding site of FGF-2 coincides structurally with the IL-1beta receptor-binding site when the two molecules are superimposed. The structural similarities between the IL-1 and the FGF system provided a framework to elucidate molecular principles of FGF-FGFR interactions. In the FGF-FGFR model proposed here, the two domains of a single FGFR wrap around a single FGF-2 molecule such that one domain of FGFR binds to the primary receptor-binding site of the FGF molecule, while the second domain of the same FGFR binds to the secondary receptor-binding site of the same FGF molecule. Finally, the proposed model is able to accommodate not only heparin-like glycosaminoglycan (HLGAG) interactions with FGF and FGFR but also FGF dimerization or oligomerization mediated by HLGAG.  (+info)

Type 2 Fibroblast Growth Factor Receptor: A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME.
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions. We have used Cre-mediated excision to generate mice lacking the IIIb form of fibroblast growth factor receptor 2 whilst retaining expression of the IIIc form. Fibroblast growth factor receptor 2(IIIb) null mice are viable until birth, but have severe defects of the limbs, lung and anterior pituitary gland. The development of these structures appears to initiate, but then fails with the tissues undergoing extensive apoptosis. There are also developmental abnormalities of the salivary glands, inner ear, teeth and skin, as well as minor defects in skull formation. Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis.. ...
Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 has complete details about market of Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 industry, Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors -Pipeline Insights, 2019 analysis and current trends.
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017 ...
TY - JOUR. T1 - Coexpression of truncated human cytomegalovirus gh with the ul115 gene product or the truncated human fibroblast growth factor receptor results in transport of gh to the cell surface. AU - Spaete, Richard R.. AU - Perot, Karen. AU - Scott, Patricia I.. AU - Nelson, Jay A.. AU - Stinski, Mark F.. AU - Pachl, Carol. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1993/4. Y1 - 1993/4. N2 - The gH glycoprotein of herpesviruses is located on the cell surface in viral-infected cells but is retained in the endoplasmic reticulum (ER) when expressed separately from a recombinant expression vector. These observations suggested the requirement for either a viral function or a viral-induced cellular function which facilitates surface expression of gH, gL fulfills this role in the herpes simplex virus (HSV)-infected cell (J. Virol. 66, 2240-2250, 1992). We have identified the gene product of the UL115 open reading frame (ORF) as the functional homologue of HSV gL in ...
Fibroblast growth factor receptor (FGFR) is a receptor-type protein tyrosine kinase. Currently known FGFR mainly includes 4 types, namely FGFR1, FGFR2, FGFR3 and FGFR4. It has been clinically found that FGFR overexpression and activation of tumor tissues in a variety of cancers can promote tumor angiogenesis and tumor cell division and proliferation. Therefore, fibroblast growth factor receptors are widely regarded as an important class of anti-tumor drug targets, and have attracted widespread attention from pharmacists in various countries. In previous research, a binding gap in the ATP-binding domain of the FGFR1 protein was discovered, and a novel FGFR1 inhibitor design idea was proposed for the spatial structure of the gap.. Structure Fibroblast growth factor receptors consist of extracellular ligand domains that bind to fibroblast growth factor, which is the largest member of the growth factor ligand family, including 22 members. The extracellular ligand domain consists of three ...
definition of FGFR1K, what does FGFR1K mean?, meaning of FGFR1K, Fibroblast Growth Factor Receptor 1 Kinase, FGFR1K stands for Fibroblast Growth Factor Receptor 1 Kinase
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013 ...
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Although drugable fibroblast growth factor receptor (FGFR) alterations in squamous cell carcinomas (SCC) of various entities are well known, little is known about FGFR modifications in squamous differentiated bladder cancer. Therefore, our study evaluated FGFR1-3 alterations as a putative therapeutic target in this subgroup. We analyzed 73 squamous differentiated bladder cancers (n = 10 pT2, n = 55 pT3, n = 8 pT4) for FGFR1-3 protein expression, FGFR1-3 copy number variations, FGFR3 chromosomal rearrangements (fluorescence in situ hybridization (FISH)) and FGFR3 mutations (SNapShot analysis). Only single cases displayed enhanced protein expression, most frequently FGFR3 overexpression (9.4% (6/64)). FISH showed no amplifications of FGFR1, 2 or 3. Break apart events were only slightly above the cut off in 12.1% (8/66) of cases and no FGFR3-TACC3 rearrangements could be proven by qPCR. FGFR3 mutations (p.S249C) were found in 8.5% (6/71) of tumors and were significantly associated with FGFR3 ...
TY - JOUR. T1 - Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. AU - Lee, Ting Wei. AU - Lee, Ting I.. AU - Lin, Yung Kuo. AU - Kao, Yu Hsun. AU - Chen, Yi Jen. PY - 2018/5/18. Y1 - 2018/5/18. N2 - Background: Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Multiple laboratory findings indicate that calcitriol may be a potential treatment for CVDs. In this study, we attempted to investigate whether calcitriol regulates FGFR1 expression to modulate the effects of FGF-2 signaling in cardiac myocytes and explored the potential regulatory mechanism. Methods: Western blot, polymerase chain reaction, small interfering RNA, fluorometric activity assay, and chromatin immunoprecipitation (ChIP) analyses were used to evaluate FGFR1, FGFR2, FGFR3, FGFR4, phosphorylated ...
cansSAR 3D Structure of 6C1C | FGFR1 KINASE COMPLEX WITH INHIBITOR SN37116 | 6C1C_A | Fibroblast growth factor receptor 1 - Also known as FGFR1_HUMAN, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling
Progression of prostate cancer from an androgen sensitive to androgen insensitive tumor has previously been shown to be accompanied by a change in alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in a rat model of prostate cancer. This change results in loss of the FGF-R2(IIIb) i …
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.. ...
Alternative initiations of translation of the human fibroblast growth factor 2 (FGF-2) mRNA, at three CUG start codons and one AUG start codon, result in the synthesis of four isoforms of FGF-2. This process has important consequences on the fate of FGF-2: the CUG-initiated products are nuclear and their constitutive expression is able to induce cell immortalization, whereas the AUG-initiated product, mostly cytoplasmic, can generate cell transformation. Thus, the different isoforms probably have distinct targets in the cell. We show here that translation initiation of the FGF-2 mRNA breaks the rule of the cap-dependent ribosome scanning mechanism. First, translation of the FGF-2 mRNA was shown to be cap independent in vitro. This cap-independent translation required a sequence located between nucleotides (nt) 192 and 256 from the 5 end of the 318-nt-long 5 untranslated region. Second, expression of bicistronic vectors in COS-7 cells indicated that the FGF-2 mRNA is translated through a ...
Recombinant Human Fibroblast growth factor 23 Protein. Synthesized in e. coli. Protein Tag: Untagged. Purity: Greater than 95% as determined by SDS-PAGE and HPLC. From $98
TY - JOUR. T1 - Expression pattern of fibroblast growth factor receptor 1 gene during chickeye development. AU - Ohuchi, H.. PY - 1993/1/1. Y1 - 1993/1/1. KW - FGF receptor. KW - chick embryo. KW - development. KW - eye. KW - in situ hybridization. UR - http://www.scopus.com/inward/record.url?scp=0027158708&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027158708&partnerID=8YFLogxK. M3 - Article. C2 - 8391203. AN - SCOPUS:0027158708. VL - 97. SP - 304. EP - 309. JO - Journal of Japanese Ophthalmological Society. JF - Journal of Japanese Ophthalmological Society. SN - 0029-0203. IS - 3. ER - ...
Purchase Recombinant Mouse Fibroblast growth factor receptor 2(Fgfr2). It is produced in in vitro E.coli expression system. High purity. Good price.
FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two distinct but emerging hot topics in FGF biology: its role in stromal cross-talk during cancer progression and the potential roles of FGFR signalling in the nucleus. These neglected areas are proving to be of great interest clinically and are intimately linked, at least in pancreatic cancer. The importance of the stroma in cancer is well accepted, both as a conduit/barrier for treatment and as a target in its own right. Nuclear receptors are less acknowledged as targets, largely due to ...
Protein target information for Chain A, Fibroblast growth factor receptor 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
House, Stacey; Weinheimer, Carla; Kovac, Attila; Ornitz, David, Endothelial-specific fibroblast growth factor receptor 1 and 2 deletion impairs vascular remodeling and recovery in an in vivo, closed-chest model of cardiac ischemia-reperfusion injury (2012). Conference Abstracts and Posters. Paper 17. http://digitalcommons.wustl.edu/em_conf/17. ...
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the CNS, stimulates proliferation of stem cells during prenatal and postnatal neurogenesis and participates in regulating cell-type ratios in many developing regions of the brain. Anomalies in FGFR1 signaling have been implicated in certain neuropsychiatric disorders. Fgfr1 expression has been shown, via in situ hybridization, to vary spatially and temporally throughout embryonic and postnatal development of the brain. However, in situ hybridization lacks sufficient resolution to identify which cell-types directly participate in FGF signaling. Furthermore, because antibodies raised against FGFR1 commonly cross-react with other members of the FGFR family, immunocytochemistry is not alone sufficient to accurately document Fgfr1 expression. Here, we
Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the CNS, stimulates proliferation of stem cells during prenatal and postnatal neurogenesis and participates in regulating cell-type ratios in many developing regions of the brain. Anomalies in FGFR1 signaling have been implicated in certain neuropsychiatric disorders. Fgfr1 expression has been shown, via in situ hybridization, to vary spatially and temporally throughout embryonic and postnatal development of the brain. However, in situ hybridization lacks sufficient resolution to identify which cell-types directly participate in FGF signaling. Furthermore, because antibodies raised against FGFR1 commonly cross-react with other members of the FGFR family, immunocytochemistry is not alone sufficient to accurately document Fgfr1 expression. Here, we
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth ...
Fibroblast growth factors (FGFs) can influence the growth and differentiation of cultured cells derived from neuroectoderm, ectoderm or mesenchyme. The FGFs interact with a family of at least four closely related receptor tyrosine kinases that are products of individual genes. To investigate the role of FGFs in the growth and differentiation of embryonic tissues and to determine whether the individual FGF receptor genes might have specific functions, we compared the localization of mRNA for two FGF receptor genes, FGFR1 (the flg gene product) and FGFR2 (the bek gene product), during limb formation and organogenesis in mouse embryos (E9.5-E16.5). Although the two genes were coexpressed in some tissues, the differential expression of FGFR1 and FGFR2 in most embryonic tissues was striking. FGFR1 was expressed diffusely in mesenchyme of limb buds, somites and organ rudiments. In contrast, FGFR2 was expressed predominantly in the epithelial cells of embryonic skin and of developing organs. The ...
Recombinant protein of human fibroblast growth factor receptor 4 (FGFR4), transcript variant 2, 20 ug available for purchase from OriGene - Your Gene Company.
A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy. Unlike other tyrosine kinase receptors activated by N-terminal truncation in tumors, this receptor, FGFR2-ROS, contains an altered C terminus generated from chromosomal rearrangement with a novel gene, designated FGFR activating gene 1 (FRAG1). While the removal of the C terminus slightly activates FGFR2, the presence of the FRAG1 sequence drastically stimulates the transforming activity and autophosphorylation of the receptor. FGFR2-ROS is expressed as a unusually large protein and is highly phosphorylated in NIH 3T3 transfectants. FRAG1 is ubiquitously expressed and encodes a predicted protein of 28 kDa lacking significant structural similarity to known proteins. Epitope-tagged FRAG1 protein showed a perinuclear localization by immunofluorescence staining. The highly activated state of FGFR2-ROS appears to be attributed to constitutive dimer ...
AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.
Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development. To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach. First, we generated …
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4. Protein Tyrosine Kinase (PTK) family; Fibroblast Growth Factor Receptor 4 (FGFR4); catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FGFR4 is part of the FGFR subfamily, which are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of ...
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2. Protein Tyrosine Kinase (PTK) family; Fibroblast Growth Factor Receptor 2 (FGFR2); catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FGFR2 is part of the FGFR subfamily, which are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of ...
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As a promising target, FGFR4 is attracting intensive pharmaceutical and academic attention for developing novel target therapy against cancers driven by FGFR4
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Das Netzwerk Genomische Medizin (NGM) Lungenkrebs wurde im März 2010 von der Kölner Lungenkrebsgruppe (Lung Cancer Group Cologne) gegründet, um zunächst in Nordrhein-Westfalen eine umfassende und qualitativ hochwertige molekulare Diagnostik für alle Patienten mit Lungenkrebs anzubieten und so die Implementierung personalisierter Therapie in der klinischen Routineversorgung zu fördern. Mittlerweile agiert das NGM bundesweit und strebt eine Flächendeckung in Deutschland an.. ...
Supplementary MaterialsSupplementary information. molecular identification capacity for aptamers as well as the superiority of Exos as organic vehicles, Apt-Exos can deliver molecular medications/fluorophores to focus on cancer tumor cells effectively, providing a appealing delivery system for cancers theranostics. Graphical Abstract Despite many developments in artificial delivery vehicles, their changeover from bench to bedside was hindered by low specificity still, high biotoxicity, and high immunogenicity.1 occurring vehicles Naturally, for example, exosomes (Exos), are anticipated to provide appealing alternatives for effective delivery of therapeutics/diagnostics.2 Exos are nanoscale membrane-enclosed vesicles (30C100 nm) secreted by various eukaryotic GDC0853 cells (e.g., spithelial cells and myeloid cells).3 They play critical assignments in cellCcell conversation through product packaging and transporting particular bioactive substances.4 In the modern times, pioneered with the Hardwood ...
Rep. 7, 46149; doi: 10.1038/srep46149 (2017). Publishers take note: Springer Character remains neutral in regards to to jurisdictional statements in published maps and institutional affiliations. Supplementary Material Supplementary Numbers:Just click here to see.(4.1M, pdf) Acknowledgments This research was backed from the Ministry of Science and Technology from the Republic Glycitein of China (give no. SKOV3 xenograft model without significant bodyweight loss. Collectively, our findings claim that MT-6 can be a powerful anticancer agent with tumor-suppressive activity and that may be further looked into for ovarian tumor therapy in the foreseeable future. Among malignant gynecological tumors, individuals with ovarian tumor have a higher mortality rate due to past due stage analysis1. Furthermore to debulking medical procedures, the typical treatment for ovarian tumor can be platinum-based chemotherapy in conjunction with taxane cytotoxic medicines, but most these patients relapse within 2 ...
For 21 of the 25 sequences, more information was obtainable and revealed that these were extracted from EBOV which were extensively passaged in cell lifestyle (= 19) or guinea pigs (= 1) or which were successively passaged in cell lifestyle, monkeys, and again cell lifestyle (= 1). and everything bat-derived cell lines examined was comparable. Furthermore, EBOV2014 replication in NHP however, not individual cells was reduced in accordance with EBOV1976, recommending that decreased cell admittance translated into decreased viral spread. Mutagenic evaluation of EBOV1976-GP and EBOV2014-GP uncovered an amino acidity polymorphism in the receptor-binding area, A82V, modulated admittance efficiency within a cell line-independent way and didnt take into account the decreased EBOV2014-GP-driven admittance into NHP cells. On the other hand, polymorphism T544I, situated in the inner fusion loop in the GP2 subunit, was discovered to lead to the admittance phenotype. These outcomes suggest that placement ...
Supplementary MaterialsSupporting Details. be used to create 3D tissue, which pays to for areas of tissues regeneration for medication advancement and regenerative medication. strong course=kwd-title Subject conditions: Assay systems, Regenerative medication, Tissue engineering Launch Organ features are preserved by vascular systems. For instance, the liver organ receives bloodstream from two huge vessels, the hepatic artery and website vein. Blood in… More →. ...
Product Name: Mouse mAb anti- human Fibroblast Growth Factor-basic (bFGF), Clone F-74Collection: AntibodySub Category: Monoclonal AntibodyImmunogen: Purified
CD334 / FGFR4 (fibroblast growth factor receptor 4), a transmembrane tyrosine kinase, which is expressed in many tissues, such as in lung, kidney, muscle, heart, pancreas, intestine and other, acts as a receptor for several fibroblast growth factors, namely FGF1, FGF2, FGF6, FGF8, and FGF19. Interaction with these growth factors initiates in cell the signaling cascades leading to the mitogenesis and cell differentiation. Presence of CD334 Gly338Arg allele correlates with prognostic parameters in various cancer studies. CD334 plays multiple roles in the organism, including those of muscle regeneration, cholesterol-to-bile acid metabolism, or glucose homeostasis ...
J:87411 Burns RC, Fairbanks TJ, Sala F, De Langhe S, Mailleux A, Thiery JP, Dickson C, Itoh N, Warburton D, Anderson KD, Bellusci S, Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev Biol. 2004 Jan 1;265(1):61-74 ...
The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression. Mol Cancer Res; 8(11); 1439-52. ©2010 AACR. ...
FGF8 - FGF8 (untagged)-Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant B available for purchase from OriGene - Your Gene Company.
Recombinant human FGFR4 (460-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. FGFR4 is a member of the fibroblast growth factor receptor family, which play a role in mitogenesis and differentiation.
J:1618 Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P, Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development. 1991 Dec;113(4):1419-34 ...
FRS3 (Fibroblast Growth Factor Receptor Substrate 3, FGFR Substrate 3, FGFR-signaling Adaptor SNT2 Suc1-associated Neurotrophic Factor Target 2, SNT-2, SNT2 ...
FGFR2 antibody (fibroblast growth factor receptor 2) for FACS, ICC/IF, IHC-P, WB. Anti-FGFR2 pAb (GTX25476) is tested in Human, Mouse samples. 100% Ab-Assurance.
FGFR2 antibody (fibroblast growth factor receptor 2) for ICC/IF, IHC-P, WB. Anti-FGFR2 pAb (GTX55622) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Looking for online definition of fibroblast growth factor receptor gene in the Medical Dictionary? fibroblast growth factor receptor gene explanation free. What is fibroblast growth factor receptor gene? Meaning of fibroblast growth factor receptor gene medical term. What does fibroblast growth factor receptor gene mean?
TY - JOUR. T1 - Fibroblast Growth Factor Receptor-3 Is Expressed in Undifferentiated Intestinal Epithelial Cells during Murine Crypt Morphogenesis. AU - Vidrich, Alda. AU - Buzan, Jenny M.. AU - Ilo, Chibuzo. AU - Bradley, Leigh. AU - Skaar, Kirstin. AU - Cohn, Steven. PY - 2004/5/1. Y1 - 2004/5/1. N2 - Prior studies have demonstrated that fibroblast growth factor receptor-3 (FGFR-3) regulates proliferation of undifferentiated intestinal epithelial cells in vitro. However, the function(s) of FGFR-3-mediated signaling during intestinal development and epithelial differentiation in vivo remain unknown. The goal of this study was to define the temporal, regional, and cell-specific patterns of FGFR-3 expression and its ligands during normal intestinal ontogeny and epithelial regeneration. Both the IIIb and IIIc isoforms of FGFR-3 mRNA, which result from differential splicing of the FGFR-3 primary transcript, were detected in mouse small intestine as early as embryonic day 16. FGFR-3 levels peaked in ...
TY - JOUR. T1 - Evaluation of the tumorigenic and angiogenic potential of human fibroblast growth factor FGF3 in nude mice. AU - Li, J. J.. AU - Friedman-Kien, A. E.. AU - Cockerell, C.. AU - Nicolaides, A.. AU - Liang, S. L.. AU - Huang, Y. Q.. PY - 1998/6/13. Y1 - 1998/6/13. N2 - Recently, the expression of fibroblast growth factor 3 (FGF3) was found in 55% of human Kaposis sarcoma (KS) tumor tissues examined, while almost no expression of FGF3 was found in normal skin. To further these studies, human FGF3 cDNA were constructed by the overlap-extension method. The proteins translated from two FGF3 cDNA, which differ only in the sequences preceding the AUG presumed to be the initiation codon, were shown to have the same molecular mass. This result suggests that translation of human FGF3, which is different from mouse FGF3, begins only at the AUG site. The human FGF cDNA was transfected into NIH3T3 cells. The NIH 3T3 cells transformed by FGF3 were then injected subcutaneously into athymic nude ...
TY - JOUR. T1 - Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. AU - Oltean, Sebastian. AU - Sorg, Brian. AU - Albrecht, Todd. AU - Bonano, Vivian. AU - Brazas, Rob. AU - Dewhirst, Mark. AU - Garcia-Blanco, Mariano. PY - 2006. Y1 - 2006. M3 - Article (Academic Journal). JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424. ER - ...
Search and download thousands of Swedish university dissertations (essays). Full text. Free. Dissertation: Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea.
negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway - Ontology Report - Rat Genome Database
TY - THES. T1 - Fibroblast growth factor receptor 1 signaling in the early development of the midbrain-hindbrain and pharyngeal region. AU - Trokovic, Ras. PY - 2005. Y1 - 2005. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. KW - aivot. KW - nielu. KW - kehitys. KW - alkionkehitys. KW - väitöskirjat. KW - embryologia. M3 - Doctoral Thesis. SN - 952-10-2296-5. T3 - Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki. PB - University of Helsinki. CY - Helsinki. ER - ...
Antibodies for proteins involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development pathways, according to their Panther/Gene Ontology Classification
Growth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair. © 2006 Elsevier B.V. All rights reserved ...
Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes. Biological effects mediated by FGF-2 include inhibition of proteoglycan production, up-regulation of matrix metalloproteinase-13 (MMP-13), and stimulation of other catabolic factors. In this study, we identified the specific receptor responsible for the catabolic functions of FGF-2, and established a pathophysiological connection between the FGF-2 receptor and OA. Primary human articular chondrocytes were cultured in monolayer (24 hours) or alginate beads (21 days), and stimulated with FGF-2 or FGF18, in the presence or absence of FGFR1 (FGF receptor 1) inhibitor. Proteoglycan accumulation and chondrocyte proliferation were assessed by dimethylmethylene blue (DMMB) assay and DNA assay, respectively. Expression of FGFRs (FGFR1 to FGFR4) was assessed by flow cytometry,
Clone REA1243 recognizes the human CD334 (FGFR4) antigen, known as Fibroblast growth factor receptor 4, which is a member of the fibroblast growth factor receptor family. This cell surface tyrosine kinase is a high affinity receptor for both acidic and basic fibroblast growth factor. The binding of CD334 with the acidic fibroblast growth factors FGF2, FGF6, and FGF8, FGF19 and GFG1 induces mitogenesis and differentiation. CD334 is expressed in adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues of human fetuses. A soluble-form splice variant of FGFR 4 was identified in human gastrointestinal epithelial cells and cancer cells.Additional information: Clone REA1243 displays negligible binding to Fc receptors. - Ireland
ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice variant affects the function of ADAM15. Here, we show that ADAM15B has enhanced catalytic activity in cell-based assays compared with ADAM15A, which lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an assay for catalytic activity. Moreover, the enhanced activity of ADAM15B compared with ADAM15A depends on Src because it is abolished by Src-kinase inhibitors and in Src(-/-) cells, but not in Src(-/-) cells rescued with Src. These findings provide insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B, and suggest that inhibitors of the ADAM15 protease activity or of the
Rapid appearance of resistance to fibroblast growth factor receptor (FGFR) inhibitors hampers targeted regimens in bladder cancer. In the present study, we evaluated whether SIP-SII, a sulphated derivative of the polysaccharide in Sepiella maindroni (spineless cuttlefish) ink used in traditional Chinese medicine, could attenuate resistance to FGFR inhibition in bladder cancer cells. In vitro assays indicated that SIP-SII reduced cell viability and migration, restricted cell cycle progression, and increased apoptosis in parallel with decreased AKT phosphorylation and downregulation of CDK4, MMP2, and Bcl-2 in RT112 and JMSU1 cells. Synergistic effects on cell viability were observed when SIP-SII was combined with the small-molecule FGFR inhibitor AZD4547. Specific Akt targeting by SIP-SII was suggested by the fact that neither Akt knockdown nor the selective PI3K inhibitor BKM120 enhanced the inhibitory effects of SIP-II, while expression of a constitutively active Akt mutant rescued SIP-SII
Recombinant Fibroblast Growth Factor 13 (FGF13) Protein. Species: Human. Source: Escherichia coli (E. coli). Order product ABIN6304346.
Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics. Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21. A single injection of R1MAb into obese diabetic mice induced acute and sustained amelioration of hyperglycemia, along with marked improvement in hyperinsulinemia, hyperlipidemia, and hepatosteatosis. R1MAb activated the mitogen-activated protein kinase pathway in adipose tissues, but not in liver, and neither FGF21 nor R1MAb improved glucose clearance in lipoatrophic mice, which suggests that adipose tissues played a central role in the observed metabolic effects. In brown adipose tissues, both FGF21 and R1MAb induced phosphorylation of CREB (cyclic adenosine 5′-monophosphate response ...
The FGFR3 receptor tyrosine kinase represents an attractive target for therapy due to its role in several human disorders, including skeletal dysplasias, multiple myeloma, and cervical and bladder carcinomas. By using molecular library screening, we identified a compound named NF449 with inhibitory activity toward FGFR3 signaling. In cultured chondrocytes and murine limb organ culture, NF449 rescued FGFR3-mediated extracellular matrix loss and growth inhibition, which represent two major cellular phenotypes of aberrant FGFR3 signaling in cartilage. Similarly, NF449 antagonized FGFR3 action in the multiple myeloma cell lines OPM2 and KMS11. In cell-free kinase assays, NF449 inhibited the kinase activity of both wild type and a disease-associated FGFR3 mutant (K650E) in a fashion that appeared non-competitive with ATP ...
Lab Rotation Projects Areas of interest; Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, (produced by osteoblasts, osteoclasts and stromal cells) regulate bone development, remodeling and disorders of bone. Project 1- Fgf2 knockout and Fgf2 transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone including osteoporosis. Project 2- Examination of the effects of cytokines and hormones including interleukin-1 (IL-1), parathyroid hormone (PTH), insulin-like growth factor-I (IGF-I), transforming growth factor beta (TGF?), prostaglandins (PGs) and glucocorticoids on FGF2 and FGFR signaling, gene transcription, mRNA stability and the activity of transfected Fgf2 promoter-luciferase reporter gene constructs.. ...
We sought to describe corneal epithelial changes after using epidermal (EGFR) or fibroblast growth factor receptor (FGFR) inhibitors as chemotherapy and to clarify incidence and prognosis. Retrospective chart review. Among 6871 patients and 17 EGFR or FGFR inhibitors, 1161 patients (16.9%) referred for ophthalmologic examination. In total, 1145 patients had disease-related or unrelated ocular complications. Among 16 patients with treatment-related ocular complications, three patients had treatment-related radiation retinopathy and one patient showed treatment-related corneal ulcer. Finally the authors identified that, in 12 patients, three EGFR inhibitors and two FGFR inhibitors caused corneal epithelial lesions. Vandetanib, Osimertinib, and ABT-414 caused vortex keratopathy in nine patients, while ASP-5878 and FPA-144 caused epithelial changes resembling corneal dysmaturation in three patients. The mean interval until symptoms appeared was 246 days with vandetanib, 196 days with osimertinib, 30 days
The mouse thymic primordium is formed around E10.5 as an epithelial bud from the third pharyngeal pouch and mesenchyme that differentiates from neural crest cells (1, 2, 3). At about E11.5, the epithelial primordium is first colonized by T cell progenitors that migrate in from blood vessels in the surrounding mesenchyme. At E12, the mesenchyme surrounds, but has not penetrated, the epithelium. Removal of the mesenchyme at this critical phase prevented the development of the epithelium in vitro (36). Subsequently, Shinohara and Honjo showed that the mesenchyme of the early E12 thymus influences MHC class II expression in the epithelium, but they did not study the effects on lymphopoiesis (37, 38). At E12, thymic explants show a limited lymphoid developmental capacity, which can be enhanced by addition of fibroblasts (39, 40).. In a recent study, E12 thymic lobes with intact mesenchyme were shown to generate all T cell populations in vitro, but lobes from which mesenchyme has been removed show ...
Soluble FGFR-1a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric.
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We examined the localization of basic fibroblast growth factor (bFGF) in the developing embryonic and newborn rat nervous system using 2 anti-bFGF antibodies. Embryonic (E13, E14, E15, E16, E17, and E18) and newborn tissues were examined. Between E16 and E17 strong bFGF immunoreactivity (IR) was det...
Aberrant signaling through Fibroblast Growth Factor Receptors (FGFR) has been reported in multiple types of human cancers. FGFR4 signaling contributes to the development and progression of subsets of cancer: in approximately 10 percent of hepatocellular carcinoma (HCC), genetic amplification of FGF19, encoding an endocrine FGF ligand that activates FGFR4-KLB receptors, has been reported. In models with this alteration, FGF19-FGFR4 signaling is oncogenic and antagonism of the FGF19-FGFR4 axis has been shown to be efficacious suggesting that selective targeting of FGFR4 may be an effective strategy for malignancies with FGFR4 activation.. We describe the preclinical characterization of INCB062079 a potent and selective inhibitor of the FGFR4 kinase. In biochemical assays INCB062079 inhibited FGFR4 with low nM potency and exhibited at least 250-fold selectivity against other FGFR kinases and greater than 800-fold selectivity against a large kinase panel. This selectivity derives from the ability of ...
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder- stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed. ...
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Deregulated FGFR expression plays an important role in driving many cancers. In this report, Zhang and colleagues identify FGFR1 gene amplification in a cohort of Chinese squamous cell carcinoma, in which effective treatment therapies are desperately needed. Utility for the novel and selective FGFR inhibitor, AZD4547, was shown through in vitro tumor cell proliferation studies, and importantly, translational significance was established by the observation of tumor stasis or regression effects in a panel of FGFR1-amplified squamous lung patient-derived tumor xenograft models, but not in nonamplified models. These data thus provide a strong rationale for the investigation of AZD4547 as a novel therapeutic option for NSCLC patients with tumors harboring FGFR1 amplification.. ...
Our present data indicate that (a) FGF-induced Erk1/2 activation is required for Ets activation, (b) subsequent Ets binding to the FOX:ETS motif in the first intron enhancer of the Vegfr2 gene plays an important role in VEGFR2 expression, and (c) this FGF regulation of VEGFR2 expression plays a critical role in adult neovascularization and vascular integrity (Figure 6E). Early observation pointed to critical interplay and synergism of FGF and VEGF systems in angiogenic assays, with a combination of VEGF and FGF2 inducing a far stronger in vitro angiogenic response than either growth factor by itself (21). This was thought to be due to an induction of VEGFR2 expression by FGF2 while VEGF induction of FGFR expression was not seen (22). This has been attributed to the involvement of Erk and PKC signaling, but not yet been demonstrated (23). Our data demonstrate, for the first time to our knowledge, that Erk1/2 activation is critical for FGF-dependent regulation of VEGFR2 expression. Moreover, our ...
fibroblast growth factor receptor-4 FGFR4 contains rs351855 which is likely to cause a hard to treat version of breast cancer. ...
fibroblast growth factor receptor-4 FGFR4 contains rs351855 which is likely to cause a hard to treat version of breast cancer. ...
Complete information for FGFR3P4 gene (Pseudogene), Fibroblast Growth Factor Receptor 3 Pseudogene 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in a broad range of cancers and occur in ~20% of ICCs. As seen with other targeted therapies, however, acquired resistance has limited the efficacy of selective FGFR kinase inhibitors such as BGJ398. In a phase II trial of patients with advanced refractory cholangiocarcinoma harboring an FGFR gene alteration, BGJ398 displayed an overall response rate of 22%, but the durability of response was short in some patients. We report the molecular basis of acquired resistance in 4 patients with advanced FGFR2-fusion positive ICC via integrative genomic characterization of cell-free circulating tumor DNA (cfDNA), the primary tumor, and metastases. Each patient enjoyed an initial response, but all subsequently progressed within 10 months. Serial analysis of cfDNA revealed multiple point mutations in the FGFR2 kinase domain at progression (Table 1). The gatekeeper mutation, p. V564F, sterically ...
Cellular signaling via EGFR is initiated by ligand-stimulated autophosphorylation of key tyrosine residues of EGFR that have been shown to recruit a host of downstream signaling proteins leading to activation of various cellular pathways responsible for controlling growth and survival (28). Our previous study with FGFR1 (fibroblast growth factor receptor 1) have shown that the order of autophosphorylation is important in providing both temporal and spatial resolutions to receptor signaling and this order is perturbed in an oncogenic form of FGFR1 (29, 30). Therefore, the pattern and timing of phosphorylation events on EGFR may be important for proper orchestration of downstream partner recruitment and activation of relevant pathways in a defined manner for appropriate regulation of cell growth. Identifying specific phosphosignatures of global EGFR signaling may offer insights that may be useful for predicting patient response to EGFR-targeted therapy as well as combination treatments. Our ...
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In this study, we report that high FGFR1 protein expression is a prognostic biomarker in HPV-negative HNSCC. Furthermore, the frequent overexpression of FGFR1 in HNSCC provides a rationale to test FGFR inhibitors in clinical trials. Here, we demonstrated that combined EGFR/FGFR inhibitor treatment can be used to treat FGFR inhibitor-resistant HNSCC.. Our finding that 82% of HPV-positive and 75% of HPV-negative HNSCC overexpress FGFR1 is in concordance with previous reports, but it differs from a study by Freier and colleagues, which reported high FGFR1 expression in only 12% of OSCC (5, 17, 31, 32). In addition, we observed prognostic value for FGFR1 protein expression in HPV-negative HNSCC, which has not been reported by previous studies, although Hase and colleagues reported prognostic value for FGFR1 expression in oral cancer-associated fibroblast (32, 33). These contradictions might be explained by differences in anti-FGFR1 antibodies to determine protein expression or study populations. ...
Verzeichniss bekannter Schmettlinge, 1816-[1826] Verz. bek. Schmett. (1): [1-3], 4-16 (1816), (2): 17-32 (1819), (3): 33-48 (1819), (4): 49-64 (1819), (5): 65-80 (1819), (6): 81-96 (1819), (7): 97-112 (1819), (8): 113-128 (1819), (9): 129-144 (1819), (10): 145-160 (1819), (11): 161-176 (1819), (12): 177-192 (1820), (13): 193-208 (1820), (14): 209-224 (1821), (15): 225-240 (1821), (16): 241-256 (1821), (17): 257-272 (1823), (18): 273-288 (1823), (19): 289-304 (1823), (20): 305-320 (1825), (21): 321-336 (1825), (22): 337-352 (1825), (23-27): 353-431 ([1825 ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ... transforming growth factor beta receptor binding. • growth factor activity. • transforming growth factor beta binding. • type ... Receptor/signaling modulators. Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine ... type III transforming growth factor beta receptor binding. • cytokine activity. • type I transforming growth factor beta ...
Powers CJ, McLeskey SW, Wellstein A (Sep 2000). "Fibroblast growth factors, their receptors and signaling". Endocrine-Related ... "Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional ... effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems ... "Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis". Molecular ...
"Cellular signaling by fibroblast growth factor receptors". Cytokine & Growth Factor Reviews. 16 (2): 139-149. doi:10.1016/j. ... In mice, one gene known to regulate limb growth is prx1, which encodes a transcription factor. The expression patterns of prx1 ... De Luca F, Barnes KM, Uyeda JA, De-Levi S, Abad V, Palese T, Mericq V, Baron J (2001). "Regulation of growth plate ...
"The molecular biology of heparan sulfate fibroblast growth factor receptors". Annals of the New York Academy of Sciences. 638: ... Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans ... Jaakkola P, Jalkanen M (1999). Transcriptional regulation of Syndecan-1 expression by growth factors. Progress in Nucleic Acid ... January 1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Bonaldo ...
... fibroblast growth factor 6". Vainikka S, Partanen J, Bellosta P, et al. (1992). "Fibroblast growth factor receptor-4 shows ... 1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292-7. doi:10.1074/jbc.271.25. ... "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". J Biol Chem. 281 (23): 15694- ... "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor ...
"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". The Journal of Biological ... Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene. The protein encoded by this gene is a ... "Entrez Gene: Fibroblast growth factor 22". This article incorporates text from the United States National Library of Medicine, ... member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, ...
"Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand ... "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors". ... "Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal ... Clements DA, Wang JK, Dionne CA, Goldfarb M (May 1993). "Activation of fibroblast growth factor (FGF) receptors by recombinant ...
Fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) was identified in a study on myeloproliferative syndrome (EMS ... The protein encoded by the FGFR1 gene belongs to the fibroblast growth factor receptor family. FGFRs usually contain an ... FGFR1OP2, when fused with the fibroblast growth factor receptor 1 (FGFR1), is shown to cause myeloproliferative syndrome. ... Ornitz, DM; Xu (1996). "Receptor specificity of the fibroblast growth factor family". Journal of Biological Chemistry. 271 (25 ...
June 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292 ... "Role of fibroblast growth factor 8 in growth and progression of hormonal cancer". Cytokine & Growth Factor Reviews. 18 (3-4): ... Powers CJ, McLeskey SW, Wellstein A (September 2000). "Fibroblast growth factors, their receptors and signaling". Endocrine- ... May 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor ...
... through fibroblast growth factors and its respective receptors utilizes the receptor tyrosine pathway. This ... Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and ... Growth and differentiation factors (GDFs) Growth factor and clotting factors are paracrine signaling agents. The local action ... Lappi, Douglas A. (1995). "Tumor targeting through fibroblast growth factor receptors". Seminars in Cancer Biology. 6 (5): 279- ...
FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as ... "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292-7. doi:10.1074/jbc.271.25.15292. ... a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 ( ... a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 ( ...
"Outline structures for the extracellular domains of the fibroblast growth factor receptors". Nature Structural Biology. 2 (12 ... subscription required) Chothia, Cyrus (1973). The crystal structures of some molecules active at cholinergic nerve receptors. ... Canonical structures of immunoglobulins and T cell receptors (PhD thesis). University of Cambridge. "Dr Bissan Al-Lazikani Team ... "Canonical structures for the hypervariable regions of T cell alphabeta receptors". Journal of Molecular Biology. 295 (4): 979- ...
... has been shown to interact with Fibroblast growth factor receptor 3. GRCh38: Ensembl release 89: ENSG00000102678 - Ensembl ... Tsai SJ, Wu MH, Chen HM, Chuang PC, Wing LY (July 2002). "Fibroblast growth factor-9 is an endometrial stromal growth factor". ... "Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)". Sánchez L, Chaouiya C (May 2016). "Primary sex ... "Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces". Acta ...
Fibroblasts contain the receptor for this growth factor. Thus the cell "thinks" it is producing a structural protein, but it ... However, the resulting fusion protein is processed into a mature platelet-derived growth factor which is a potent growth factor ... with the platelet-derived growth factor (PDGF) gene. The fibroblast, the cell of origin of this tumor, expresses the fusion ... As with many other stromal neoplasms, DFSPs appear to express low levels of hormone receptors, which may be one factor that ...
September 2016). "Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast ... "The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 ... "Co-receptor requirements for fibroblast growth factor-19 signaling". J. Biol. Chem. 282 (40): 29069-72. doi:10.1074/jbc. ... Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating ...
Keratinocyte growth factor (KGF) resides in the family of fibroblast growth factor (FGF). The drug's target is the KGF receptor ... recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing ... is a truncated human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. KGF stimulates the growth of ... Palifermin reduces the incidence and duration of severe oral mucositis by protecting those cells and stimulating the growth of ...
... factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor ... "The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor". Nature. 373 (6515): 615-20. doi:10.1038/ ... "Identification of a cysteine-rich receptor for fibroblast growth factors". Mol. Cell. Biol. 12 (12): 5600-9. doi:10.1128/MCB. ... MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization". J. Cell Sci. 118 ( ...
"Familial craniosynostosis due to Pro250Arg mutation in the fibroblast growth factor receptor 3 gene". Ulster Med J. 70 (70): 47 ... This mutation causes the FGFR3 protein to be overly active; it interferes with normal bone growth, and allows skull bones to ... This mutation causes the FGFR3 protein to be overly active, which interferes with normal bone growth and allows the bones of ... The abnormal growth patterns continue throughout the growing years; therefore, intervention, accurate diagnosis, and a ...
New in vivo and in vitro studies have proven that the upregulation of FGFR2, a subset of the Fibroblast growth factor receptor ... "Fibroblast growth factor receptor promotes progression of cutaneous squamous cell carcinoma". Molecular Carcinogenesis. 58 (10 ... The greatest risk factor is high total exposure to ultraviolet radiation from the Sun. Other risks include prior scars, chronic ... Risk factors for squamous cell carcinoma varies with age, gender, race, geography, and genetics. The incidence of SCC increases ...
... platelet-derived growth factor receptor), RAF kinase, FLT3 (Fms-like tyrosine kinase-3) and KIT (stem cell factor receptor). ... Tumor types such as breast carcinoma show amplification of fibroblast growth factor related genes. Simultaneous inhibition of ... The other receptors in the family are VEGFR-1 and VEGFR-3. These receptors are a type of transmembrane kinase receptors and ... "Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and new inhibitors". Journal of Medicinal Chemistry. 55 (24): 10797- ...
"Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry". Molecular ... "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". The ... to the APOBEC-1 complementation factor (ACF), or directly to RNA itself. Isoform 1 is also implicated with other RBPs in the ... "The acidic domain is a unique structural feature of the splicing factor SYNCRIP". Protein Science. 25 (8): 1545-50. doi:10.1002 ...
Vajo, Zoltan; Francomano CA; Wilkin DJ (2000). "The molecular and genetic basis of fibroblast growth factor receptor 3 ... It can be associated with missense mutations in fibroblast growth factor receptor-3. It is inherited in an autosomal dominant ... "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which ... Nikkel, Sarah M.; Major, Nathalie; King, W. James (2013-12-01). "Growth and development in thanatophoric dysplasia - an update ...
She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss ... "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2". Nature Genetics. 8 (3 ... a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nature Genetics. 15 (1): 36-41. doi:10.1038/ng0197 ...
The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. ... Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene. This gene encodes a membrane protein ... Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003). "Sef inhibits fibroblast growth factor signaling by inhibiting ... The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein ...
... on chromosome 8 or the fibroblast growth factor receptor 2 (FGFR2) gene on chromosome 10. These genes code for fibroblast ... 1994). "A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome". Nat Genet. 8 (3): 269-74. doi: ... Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped ... Pfeiffer syndrome is strongly associated with mutations of the fibroblast growth factor receptor 1 (FGFR1) ...
... in multiple myeloma involves the fibroblast growth-factor receptor 3 gene". Blood. 90 (10): 4062-70. doi:10.1182/blood.V90.10. ... in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3". ...
"Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated ... Bass MD, Humphries MJ (2002). "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor ... "Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor ... Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. Syndecan-4 binds to FGF and mediates ...
August 2007). "Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain ... Several studies have shown that the fibroblast growth factor (FGF) is secreted from the midbrain-rhombomere 1 boundary. These ... Each rhombomere has its own set of receptors, and the same receptors can cause different actions. For example, one study showed ... and for neuron growth and apoptosis. The types of receptors, as well, can vary their activity to be cell-specific. Rhombomeres ...
It is linked to a mutation in the fibroblast growth factor receptor-3. More than 250,000 people in the world are diagnosed with ... The home setting for an achondroplastic child should be modified in a way that is fitting for a child with a growth mutation. ... There are specific ways to raise a child diagnosed with achondroplasia that will be beneficial to their growth and aging. ... Because achondroplastic children have different genes, their growth cycle should be expected to differ from that of a non- ...
... signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening ... 2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells ... Hu MC, Wang YP, Qiu WR (1999). "Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to ... "Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis". Journal of Biological Chemistry. ...
Fibroblast growth factor and fibroblast growth factor receptors regulate fetal bone growth and are expressed in cranial sutures ... The condition is associated with syndromes caused by mutations in fibroblast growth factor receptor genes (FGFR), including ... likely through effects on fibroblast growth factor receptor genes.[28][29][30][31][32] ... The following syndromes are associated with fibroblast growth factor receptors:. Name of syndrome Other signs and symptoms ( ...
The SP receptor promoter contains regions that are sensitive to cAMP, AP-1, AP-4, CEBPB,[13] and epidermal growth factor. ... fibroblasts, stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16 ... ReceptorEdit. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).[8] It belongs to the ... Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C (Oct 2004). "Metalloproteinases and transforming growth factor-alpha mediate ...
Indeed, Rho-dependent response is stimulated by the action of growth factors on Rac protein.[8] ... Alan Hall showed the specificity of Rho in the stimulation of focal adhesions and stress fibres formation in fibroblasts in the ... Using immunoblotting techniques, Hall showed that activation of endogenous Gaq via G protein-coupled receptors (GCPRs) could in ... The inhibition of endogenous Rac function by mutants N17rac and V12rac1 prevented growth factor-induced membrane ruffling. In ...
Gene expression profiling revealed the prevalence of specific fibroblast growth factors (FGFs) and FGF receptors in NSCLC cell ... "Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells". Molecular ... For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF family ligands in non-small- ... One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. ...
Cytokine Growth Factor Rev. 14 (2): 155-74. PMID 12651226. doi:10.1016/S1359-6101(03)00002-9. ... 17,0 17,1 17,2 17,3 Moseley TA, Haudenschild DR, Rose L, Reddi AH (2003). "Interleukin-17 family and IL-17 receptors". ... fibroblast, pluća, mijelo-monocitne ćelije, i stromalne ćelije koštane srži.[4][16][17] ... "Transforming growth factor-beta induces development of the T(H)17 lineage". Nature 441 (7090): 231-4. PMID 16648837. doi: ...
... growth factors, neurotrophic factors, anti-inflammatory drugs, antioxidants, anti-apoptotic drugs, and drugs to improve ... the AMPA receptor) that is more permeable to calcium. In ALS, there are decreased levels of excitatory amino acid transporter 2 ... can be used to convert skin fibroblasts into motor neurons.[11] It is now possible to generate iPSCs from people with ALS, ... genetic factors and environmental factors are thought to be of roughly equal importance.[13] The genetic factors are better ...
Calabretta B، Battini R، Kaczmarek L، de Riel JK، Baserga R (1986). "Molecular cloning of the cDNA for a growth factor- ... identified by an anti-prolactin receptor antiserum". J. Biol. Chem. 263 (5): 2397-401. PMID 2448309. ... positive regulation of fibroblast proliferation. • ion transmembrane transport. • توصيل الإشارة. المصادر:Amigo / QuickGO. ... "Structural and functional analysis of a growth-regulated gene, the human calcyclin". J. Biol. Chem. 262 (17): 8325-32. PMID ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for receptor ... "Vascular endothelial growth factor B, a novel growth factor for endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2567- ...
regulation of multicellular organism growth. • regulation of insulin receptor signaling pathway. • regulation of lipid ... transcription factor complex. • bicellular tight junction. • nucleoplasm. • nucleolus. • perinuclear region of cytoplasm. • ... positive regulation of fibroblast proliferation. • response to hyperoxia. • positive regulation of translation. • regulation of ... Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Clark IA (June-August 2007). "How TNF was recognized as a key mechanism of disease". Cytokine Growth Factor Rev. 18 (3-4): 335- ... fibroblasts, and neurons.[5] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ...
M344 is a benzamide that shows promising results in fibroblast cell culture and increases level of splicing factors known to ... a brain-derived neurotrophic factor that function in nerve growth and maintenance within the brain.[86][20]. *Vorinostat (SAHA) ... dopamine 2 receptor, and Penk1 - preproenkephalin).[84] For both late- and early-onset Huntington's, the H3 and H4 core ... a neurotrophic factor important for long-term memory.[66] Expression of CREB, an activity-dependent transcription factor ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults."[5] ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults. ... It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in ...
... resulting in accumulation of the ligase substrates and downregulation of fibroblast growth factor 8 (FGF8) and FGF10. This ... and its receptor, bFGF and IL-6 appear to be required for endothelial cell migration during angiogenesis. Thalidomide and its ... or the growth of new blood vessels has been reported to correspond with MM progression where vascular endothelial growth factor ... Thalidomide was discovered to inhibit tumour necrosis factor-alpha (TNF-α) in 1991. TNF-α is a cytokine produced by macrophages ...
"Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor". Science. 264 (5161): 965-8 ... Although IL-15 mRNA can be found in many cells and tissues including mast cells, cancer cells or fibroblasts, this cytokine is ... A hematopoietin receptor, the IL-15 receptor, that binds IL-15 propagates its function. Some subunits of the IL-15 receptor are ... "Cytokine & Growth Factor Reviews. 22 (2): 99-108. doi:10.1016/j.cytogfr.2011.04.001. PMC 3994286. PMID 21531164.. ...
Platelet-Derived Growth Factor Receptor), and PDGFR β. Unlike most RTK inhibitors, crenolanib is a type I mutant-specific ... In stromal fibroblasts, PDGFRα activation leads to local tissue invasion, production and secretion of VEGF, and elevated ... a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Cancers". Journal ... Type III Receptor tyrosine kinase, including FLT3, PDGFRα and PDGFRβ, have been directly implicated in the pathogenesis of ...
Growth factors. *Epidermal growth factor. *Fibroblast growth factor. *Nerve growth factor. *Platelet-derived growth factor ... transmembrane-ephrin receptor activity. • protein binding. • ephrin receptor binding. Cellular component. • anchored component ... The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been ... Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151-81. doi:10.1016/S0163-7258(97)00112-5. PMID ...
"Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor". The EMBO Journal. 10 (10): ... Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts". ... Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is ... Nakamura T (1992). "Structure and function of hepatocyte growth factor". Progress in Growth Factor Research. 3 (1): 67-85. doi: ...
"Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding ... Fibroblasts, smooth muscle cells and endothelial cells express low levels of ALOX5.[6][7] Up-regulation of ALOX5 may occur ... "Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling". The Journal of Clinical ... Montelukast, Zafirlukast, and Pranlukast are receptor antagonists for the Cysteinyl leukotriene receptor 1 which contributes to ...
"Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human ... positive regulation of fibroblast proliferation. • replicative senescence. • response to hyperoxia. • response to ... vitamin D receptor and cyclin-dependent kinase inhibitors, p21 and p27". Nephrol. Dial. Transplant. 18 Suppl 3 (90003): iii9-12 ... negative regulation of cell growth. • cell cycle arrest. • response to organonitrogen compound. • animal organ regeneration. • ...
... epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have specific roles in breast growth ... "Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial ... tumor necrosis factor β (TNF-β), transforming growth factor α (TGF-α),[67] transforming growth factor β (TGF-β),[68] heregulin, ... "Mitogenic properties of insulin-like growth factors I and II, insulin-like growth factor binding protein-3 and epidermal growth ...
AAV encoding neurotrophic factors such as fibroblast growth factor (FGF) family members and GDNF either protected ... The photon causes the retinal bound to the receptor protein to isomerise to trans-retinal. This causes the receptor to activate ... such as vascular endothelial growth factor (VEGF) and inhibitors of angiogenesis, such as pigment epithelium-derived factor ( ... Neurotrophic factors have the ability to modulate neuronal growth during development to maintain existing cells and to allow ...
... transforming growth factors alpha,[26] beta 1 and beta 2,[27][28] fibroblast growth factors,[29] epidermal growth factor,[30] ... "Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine". Am. J. Clin. Nutr. ... granulocyte-macrophage-stimulating growth factor,[31] platelet-derived growth factor,[31] vascular endothelial growth factor,[ ... 1997). "Identification and partial purification of a basic fibroblast growth factor-like growth factor derived from bovine ...
Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by ... are non-receptor tyrosine kinases essential for the activation of signaling that is mediated by cytokine receptors lacking ... The V617F mutation appears to make hematopoietic cells more sensitive to growth factors that need JAK2 for signal transduction ... However, the proliferation of fibroblasts and deposition of collagen is a secondary phenomenon, and the fibroblasts themselves ...
ಇನ್ಸುಲಿನ್‌-ಸದೃಶ ವರ್ಧನಾಂಶ (insulin-like growth factor-1)ವನ್ನೂ (IGF-1) ಯಕೃತ್ತು ಉತ್ಪಾದಿಸುತ್ತದೆ. ಇದು ಬಾಲ್ಯದಲ್ಲಿನ ಬೆಳವಣಿಗೆಯಲ್ಲಿ ... "p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver". ...
... vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). These ... inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex". ... Feb 2007). "Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and future directions ... "Vascular Endothelial Growth Factor", Madame Curie Bioscience Database, Landes Bioscience, retrieved January 25, 2012. ...
... 그 종류도 fibroblast growth factors[20],[21], transforming growth factor-β (TGF-β)[22], ... Tanihara H, Inatani M, and Honda Y. Growth factors and their receptors in the retina and pigment epithelium. Prog Retin Eye Res ... insulin-like growth factor-1 (IGF-1)[23], ciliary neurotrophic factor (CNTF)[24], pigment epithelium-derived factor (PEDF)[25] ... Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells. ...
Bersch B, Hernandez JF, Marion D, Arlaud GJ (February 1998). "Solution structure of the epidermal growth factor (EGF)-like ... Katz Y, Strunk RC (March 1989). "Synthesis and regulation of C1 inhibitor in human skin fibroblasts". Journal of Immunology. ... "Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region". ...
vascular endothelial growth factor receptor signaling pathway. • growth hormone receptor signaling pathway. • 血管発生. • ... "Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". The Journal ... transforming growth factor beta receptor signaling pathway. • cellular response to transforming growth factor beta stimulus. • ... epidermal growth factor receptor signaling pathway. • 自己リン酸化. • nuclear migration. • negative regulation of autophagy. • ...
epidermal growth factor receptor signaling pathway. • protein kinase B signaling. • Fc-gamma receptor signaling pathway ... negative regulation of fibroblast apoptotic process. • regulation of gene expression. • liver development. • adipose tissue ... vascular endothelial growth factor receptor signaling pathway. • vasculature development. • angiogenesis. • insulin receptor ... with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes (HER2 +). The three hotspot ...
insulin receptor binding. • growth factor activity. • integrin binding. • ربط بروتيني. • insulin-like growth factor receptor ... positive regulation of fibroblast proliferation. • ERK1 and ERK2 cascade. • negative regulation of extrinsic apoptotic ... insulin-like growth factor binding protein complex. • platelet alpha granule lumen. • insulin-like growth factor ternary ... insulin-like growth factor receptor signaling pathway. • negative regulation of apoptotic process. • positive regulation of ...
... see also Fibroblast growth factor receptor 4) (= CD334) FGFRL1 (see also Fibroblast growth factor receptor-like 1) FGFR6 The ... see also Fibroblast growth factor receptor 1) (= CD331) FGFR2 (see also Fibroblast growth factor receptor 2) (= CD332) FGFR3 ( ... The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast ... These receptors bind fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 members. ...
Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.. Wang J1, Yu W, Cai Y, Ren C, ... Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and ... Altered Fibroblast Growth Factor Receptor 4 Stability Promotes Prostate Cancer Progression. Neoplasia. 2008 Aug;10(8):847-856. ... Altered Fibroblast Growth Factor Receptor 4 Stability Promotes Prostate Cancer Progression. Neoplasia. 2008 Aug;10(8):847-856. ...
FGFR2 is a receptor for fibroblast growth factor. The protein encoded by this gene is a member of the fibroblast growth factor ... "Entrez Gene: FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, ... Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and ... Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is ...
... such as those mediated by the epidermal growth factor receptor and platelet-derived growth factor receptor α, were associated ... Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis Message Subject. (Your Name) has forwarded a page to ... Fibroblast growth factors (FGFs) play important roles in the control of embryonic and postnatal skeletal development by ... Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias. ...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the ... The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. ... Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. ...
Fibroblast growth factor receptor 3. Fibroblast growth factor receptor 3, FGFR-3, EC 2.7.10.1 (Heparin-binding growth factor ... Fibroblast growth factor receptor subfamily.UniRule annotation. Automatic assertion according to rulesi ... Fibroblast growth factor receptorUniRule annotation. Automatic assertion according to rulesi ... Fibroblast growth factor receptorSequence analysis. Automatic assertion according to rulesi ...
The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which ... Abbreviations: FGF, fibroblast growth factor; FGFR, FGF receptor; RCS, rat chondrosarcoma; SPR, surface plasmon resonance. ... Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Shaun K ... Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity ...
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.. Deng C1, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. ... Receptor, Fibroblast Growth Factor, Type 3. *Receptors, Fibroblast Growth Factor/genetics*. *Receptors, Fibroblast Growth ... We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene ... This growth is accompanied by expansion of proliferating and hypertrophic chondrocytes within the cartilaginous growth plate. ...
Fibroblast Growth Factor Receptor 1. Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor ... fibroblast growth factor receptor 1:. Fibroblast Growth Factor Receptor 1 - Interactions. ... Fibroblast growth factor ... Read more about Fibroblast Growth Factor Receptor 1: Function, Clinical Significance, Interactions ... is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown ...
The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer ... Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both ... Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth F R. 2005;16:159-78. ... The fibroblast growth factor receptor (FGFR) family comprises 4 members: FGFR1-4 [1]. Similar to other receptor tyrosine ...
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. ... Fibroblast growth factor receptor substrate 3Add BLAST. 491. Amino acid modifications. Feature key. Position(s). Description ... "UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3.". Avery A.W., Figueroa C., Vojtek A.B.. Cell ... sp,Q91WJ0,FRS3_MOUSE Fibroblast growth factor receptor substrate 3 OS=Mus musculus OX=10090 GN=Frs3 PE=1 SV=3 ...
View mouse Fgfrl1 Chr5:108694229-108706950 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
... fibroblast growth factor receptor 4), Authors: Alberto Peláez-García, Rodrigo Barderas, J Ignacio Casal. Published in: Atlas ... growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor ... growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor ... fibroblast growth factor-activated receptor activity fibroblast growth factor-activated receptor activity fibroblast growth ...
607d) Cadherin 11 Modulate Fibroblast Growth Via Cooperation with Platelet Derived Growth Factor Receptor Beta. *Conference: ... that in cooperation with platelet derived growth factor receptor (PDGFRβ), CDH11 regulate cell growth via the PDGFRβ-AKT axis ... Interestingly, CDH11 engagement upregulated the expression of platelet derived growth factor receptor beta (PDGFRβ), as ... with PDGFRβ and suggest a novel mechanism that involves the physical interaction of CDH11 with a growth factor receptor and ...
Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers, making them attractive drug ... Jang JH, Shin KH, Park JG . Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes ... Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor ... Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical ...
... members of the tyrosine-kinase receptor family, play a crucial role in signal transduction and development. Recently, unique ... Fibroblast-growth-factor receptors (FGFRs), members of the tyrosine-kinase receptor family, play a crucial role in signal ... Fibroblast-growth-factor Receptor Mutations in Human Skeletal Disorders Trends Genet. 1995 Aug;11(8):308-13. doi: 10.1016/s0168 ... of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in ...
Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16, 139-149 (2005).. ... Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor ... Roles of fibroblast growth factor receptors in carcinogenesis. Mol. Cancer Res. 8, 1439-1452 (2010).. ... Fibroblast growth factors and their receptors in cancer. Biochem. J. 437, 199-213 (2011).. ...
... basic fibroblast growth factor receptor 1.. Introduction. Fibroblast Growth Factors (FGFs) comprise a family of at least ... Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated ... A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the ... generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein ...
Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 ... Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 ... Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 ... Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 ...
Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells.. [Koichi ... Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial ...
... Heldin, Carl-Henrik; Ek, Bo and Rönnstrand, ... Characterization of the fibroblast receptor for platelet-derived growth factor}, url = {http://dx.doi.org/10.1016/0309-1651(83) ...
Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor Brief description of study. - This is the first ... Fibroblast Growth Factor Receptor) Inhibitor ...
Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in ... Apert syndrome, associated with fibroblast growth factor receptor (FGFR) 2 mutations, is characterized by premature fusion of ... Preosteoblastic calvaria cells isolated from Apert infants and fetuses showed normal cell growth in basal conditions or in ...
... and the resulting integrin-FGF-fibroblast growth factor receptor (FGFR) ternary complex formation is essential for FGF1-induced ... while R50E still binds to the FGF receptor and heparin. In addition, R50E suppressed tumorigenesis in vivo, while wild-type (WT ... Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. ... Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting ...
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early ... Developmental expression of two murine fibroblast growth factor receptors, flg and bek ... Developmental expression of two murine fibroblast growth factor receptors, flg and bek ... Developmental expression of two murine fibroblast growth factor receptors, flg and bek ...
Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by ... Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by ... Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1 ... Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1 ...
Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development ... Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the ... Fibroblast-growth-factor-receptor-2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb ... Targeted disruption of fibroblast growth-factor (FGF) receptor-2 suggests a role for FGF signaling in pregastrulation mammalian ...
Homologues of Phosphorylated Fibroblast growth factor receptor 2b short [plasma membrane] (Rattus norvegicus) * phospho- ... Homologues of Phosphorylated Fibroblast growth factor receptor 2b short [plasma membrane] (Rattus norvegicus) * phospho- ... Homologues of Phosphorylated Fibroblast growth factor receptor 2b short [plasma membrane] (Rattus norvegicus) * phospho- ... Homologues of Phosphorylated Fibroblast growth factor receptor 2b short [plasma membrane] (Rattus norvegicus) * phospho- ...
Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs. Author(s): Gregory J. Chen, Reza Forough ... Keywords: Fibroblast growth factors (FGFs), fibroblast growth factor receptors (FGFRs), angiogenesis, antiangiogenesis, ... Keywords:Fibroblast growth factors (FGFs), fibroblast growth factor receptors (FGFRs), angiogenesis, antiangiogenesis, ... Gregory J. Chen and Reza Forough, " Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs", Recent ...
FGFR2 Fibroblast Growth Factor Receptor 2 ELISA Kit - Gentaur.com - Product info ... FGFR2 Fibroblast Growth Factor Receptor 2 ELISA Kit. FGFR2 Fibroblast Growth Factor Receptor 2 ELISA Kit is available 7 times ... GBS-D4137 , FGFR2 (Fibroblast Growth Factor Receptor 2), Human, ELISA Kit size: 1 Kit , 793.07 USD Catalog number GBS-D4137 ... Gene targetFGFR2 Fibroblast Growth Factor Receptor Alternative to gene target v-kit Hardy-Zuckerman 4 feline sarcoma viral ...
  • Fibroblast growth factor receptors (FGFR) play key roles in tumor growth via activated signaling pathways in GC. (hindawi.com)
  • Binding of fibroblast growth factors (FGFs) with high-affinity to FGFR results in kinase activation of downstream signaling pathways. (hindawi.com)
  • The FGFR family consists of 5 receptors, named FGFR1 to FGFR5. (hindawi.com)
  • Binding of FGFs to FGFRs induces receptor dimerization, conformational changes within the FGFR structure, and phosphorylation of tyrosines in the intracellular part of the receptor, including the kinase domain and the C-terminus [ 17 ]. (hindawi.com)
  • Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous. (nih.gov)
  • We show that the FGFR-4 Arg(388) polymorphism, which is present in most prostate cancer patients, results in increased receptor stability and sustained receptor activation. (nih.gov)
  • Our findings indicate that increased receptor stability and sustained FGFR-4 signaling occur in most human prostate cancers due to either the presence of a common genetic polymorphism or the expression of a protein that stabilizes FGFR-4. (nih.gov)
  • Thus, FGFR-4 signaling and receptor turnover are important potential therapeutic targets in prostate cancer. (nih.gov)
  • 293T cells were transfected with V5-tagged FGFR-4 Arg 388 or Gly 388 and cell surface receptors labeled with biotin. (nih.gov)
  • Labeled receptors were then immunoprecipitated with streptavidin-agarose and FGFR-4 detected by Western blot of the immunoprecipitates with anti-V5 antibody. (nih.gov)
  • Tagged FGFR-4 was immunoprecipitated with an anti-V5 antibody, and the phosphorylated receptor was detected by Western blot of immunoprecipitates with anti-phospho-FGF-R antibody (Tyr 641/642 ). (nih.gov)
  • FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, which in addition to FGFR1, includes FGFR2, FGFR3, FGFR4, and FGFRL1. (wikipedia.org)
  • The binding of FGF and HSPG to the extracellular ligand domain of FGFR induces receptor dimerization, activation and autophosphorylation of multiple tyrosine residues in the cytoplasmic domain of the receptor molecule. (nih.gov)
  • Additionally, interactions between FGFR signaling and other receptor tyrosine kinase networks, such as those mediated by the epidermal growth factor receptor and platelet-derived growth factor receptor α, were associated with excessive osteoblast differentiation and bone formation in the human skeletal dysplasia called craniosynostosis, which is a disorder of skull development. (sciencemag.org)
  • The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2-D3 linker bear the determinants of ligand binding and specificity. (pnas.org)
  • The biological effects of FGFs are mediated by binding to the FGF receptor (FGFR) family of receptor tyrosine kinases (FGFR1-FGFR4). (pnas.org)
  • We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene to produce severe and progressive bone dysplasia with enhanced and prolonged endochondral bone growth. (nih.gov)
  • In light of these mouse results, certain human disorders, such as achondroplasia, can be interpreted as gain-of-function mutations that activate the fundamentally negative growth control exerted by the FGFR-3 kinase. (nih.gov)
  • The fibroblast growth factor receptor (FGFR) family comprises 4 members: FGFR1-4 [ 1 ]. (nature.com)
  • In this study, we demonstrated that human astrocytomas undergo parallel changes in FGF-receptor (FGFR) expression during their progression from a benign to a malignant phenotype. (pnas.org)
  • Malignant astrocytomas also expressed an alternatively spliced form of FGFR-1 (FGFR-1 beta) containing two immunoglobulin-like disulfide loops, whereas normal human adult and fetal brains expressed a receptor form (FGFR-1 alpha) containing three immunoglobulin-like disulfide loops. (pnas.org)
  • absence of deregulated FGFR or the presence of other oncogenic drivers (human epidermal growth factor receptor 2 (HER2) or RAS) is associated with intrinsic resistance. (nature.com)
  • FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival. (springer.com)
  • In keeping with other genes implicated in neoplastic behavior, FGF/FGFR signaling is also involved in development, differentiation, growth, and survival mechanisms. (springer.com)
  • Most of the reported FGFR mutations that cause heritable human diseases are activating mutations which increase receptor signaling. (springer.com)
  • Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. (prospecbio.com)
  • Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). (prospecbio.com)
  • Fibroblast growth factors receptors (FGFR) are transmembrane protein tyrosine kinases involved in many cellular process, including growth, differentiation and angiogenesis. (springer.com)
  • FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. (clinsci.org)
  • Apert syndrome, associated with fibroblast growth factor receptor (FGFR) 2 mutations, is characterized by premature fusion of cranial sutures. (jci.org)
  • This review highlights recent findings that FGF1 directly interacts with integrin αvβ3, and the resulting integrin-FGF-fibroblast growth factor receptor (FGFR) ternary complex formation is essential for FGF1-induced cell proliferation, migration and angiogenesis. (mdpi.com)
  • The purpose of this non-interventional study is to identify participants with urothelial cancer (UC) and selected fibroblast growth factor receptor (FGFR) aberrations through molecular testing of their archival tumor tissue. (centerwatch.com)
  • The Fgfs signal through four Fgf receptor genes ( FgfR1-FgfR4 ), but alternative splicing increases FgfR diversity. (jimmunol.org)
  • Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. (aacrjournals.org)
  • We recently showed that the Apert Ser252Trp fibroblast growth factor receptor-2 (FGFR-2) mutation causes premature osteoblast differentiation and increased subperiosteal calvaria bone matrix formation. (unboundmedicine.com)
  • Immunohistochemical analysis of the Apert calvaria suture showed that the Ser252Trp FGFR-2 mutation increased type 1 collagen, osteocalcin, and osteopontin expression in preosteoblasts compared to normal, whereas cell growth was not affected. (unboundmedicine.com)
  • FGFR-2 mRNA levels were not altered in mutant cells, indicating that FGFR-2 downregulation resulted from receptor internalization rather than from changes in receptor mRNA. (unboundmedicine.com)
  • Massari F, Ciccarese C, Santoni M, Lopez-Beltran A, Scarpelli M, Montironi R, Cheng L. Targeting fibroblast growth factor receptor (FGFR) pathway in renal cell carcinoma. (umassmed.edu)
  • Herein, we describe experiments that implicate fibroblast growth factor (FGF) receptor (FGFR) transactivation in the convergence of MOR and growth factor signaling pathways in C6 cells. (aspetjournals.org)
  • In this study, we used different combinations of FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. (pubmedcentralcanada.ca)
  • Activating mutations of FGF receptor-1 (FGFR-1) and FGFR-2 cause craniosynostosis, whilst FGFR-3 is a negative regulator of chondrocyte proliferation and activating mutations cause achondroplasia. (endocrine-abstracts.org)
  • We have developed live-cell imaging methods for studying FGFR dynamics to investigate mechanisms that coordinate the interplay between receptor trafficking and signal transduction. (biologists.org)
  • Once internalized, FGFR passes through peripheral early endosomes en route to recycling and degredative compartments, through an Src- and Eps8-dependent mechanism. (biologists.org)
  • As we have characterised the Src target Eps8 as a key regulator of FGFR signalling and trafficking, and identified the early endocytic system as the site of Eps8-mediated effects, this work provides novel mechanistic insight into the reciprocal regulation of growth factor receptor signalling and trafficking. (biologists.org)
  • Among one of the actionable targets is the Fibroblast Growth Factor Receptor (FGFR) pathway, triggered by specific ligands. (preprints.org)
  • We have used the polymerase chain reaction to clone from fetal cerebellar RNA a novel member of the fibroblast growth factor receptor family, FGFR-4. (biologists.org)
  • Moreover, a TKI [(±)-1-(anti-3-hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1 H -pyrimido-[4,5- d ]pyrimidin-2-one (RO4383596)] that targets FGFRs inhibited basal FRS2 and extracellular signal-regulated kinase phosphorylation, two measures of FGFR activity, as well as proliferation and anchorage-independent growth of NSCLC cell lines that coexpress FGF2 or FGF9 and FGFRs. (aspetjournals.org)
  • FGF receptors (FGFR) as well as a number of FGF ligands, play a critical role in regulating normal mammary gland development and tissue homeostasis ( 2 ). (pubmedcentralcanada.ca)
  • Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup. (whiterose.ac.uk)
  • Although drugable fibroblast growth factor receptor (FGFR) alterations in squamous cell carcinomas (SCC) of various entities are well known, little is known about FGFR modifications in squamous differentiated bladder cancer. (whiterose.ac.uk)
  • We have examined expression of bFGF and fibroblast growth factor receptor 1 (FGFR-1) in luminal SMCs as well as endothelium at various times after injury, which allowed us to study both replicating as well as quiescent cells. (ahajournals.org)
  • These data provide evidence that in injured arteries the ligand/receptor system of bFGF and FGFR-1 may be involved in the continued proliferative response of SMCs leading to neointima formation. (ahajournals.org)
  • Also known as Fibroblast growth factor receptor (Ci-FGFR). (mybiosource.com)
  • Also known as Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (DjPTK1). (mybiosource.com)
  • A full-length representative of these four receptors consists of an extracellular region composed of three immunoglobulin-like domains which bind their proper ligands, the fibroblast growth factors (FGFs), a single hydrophobic stretch which passes through the cell's surface membrane, and a cytoplasmic tyrosine kinase domain. (wikipedia.org)
  • When bonded to FGFs, these receptors form dimers with any one of the four other FGFRs and then cross-phosphorylate key tyrosine residues on their dimer partners. (wikipedia.org)
  • it may serve as a decoy receptor by binding with and thereby diluting the action of FGFs. (wikipedia.org)
  • Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. (nih.gov)
  • Fibroblast growth factors (FGFs) play important roles in the control of embryonic and postnatal skeletal development by activating signaling through FGF receptors (FGFRs). (sciencemag.org)
  • Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. (nih.gov)
  • FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. (nih.gov)
  • Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. (nih.gov)
  • Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. (nih.gov)
  • Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. (rcsb.org)
  • The mammalian fibroblast growth factors (FGFs) (FGF1-FGF23) constitute a large family of structurally related ligands that are involved in a multitude of biological processes from embryogenesis to adult homeostasis ( 1 ). (pnas.org)
  • FGFs have been shown to require heparan sulfate or soluble heparin to bind with high affinity to FGFRs and to induce receptor dimerization and activation ( 5 - 7 ). (pnas.org)
  • Elevated expression of fibroblast growth factors (FGFs) in astrocytomas has implicated the FGF family of mitogens in the initiation and progression of astrocyte-derived tumors. (pnas.org)
  • The fibroblast growth factors (FGFs) act via four receptor tyrosine kinases (FGF receptors (FGFRs)) to elicit diverse physiological responses. (nature.com)
  • Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. (springer.com)
  • Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. (prospecbio.com)
  • Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. (mdpi.com)
  • Because we had some preliminary evidence that fibroblast growth factor receptors (FGFRs) were expressed in the early pancreas, we investigated the effect of fibroblast growth factors (FGFs) during embryonic pancreatic development. (diabetesjournals.org)
  • Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). (eurekaselect.com)
  • The focus of the present review is to survey what is known about the role of the currently identified FGFs and their four high affinity tyrosine kinase receptors in diseases and the angiogenesis-targeted drugs currently in clinical trials. (eurekaselect.com)
  • From this reservoir, FGFs may act directly on target cells by binding to specific receptor tyrosine kinases and this binding induces receptor dimerization and activation, ultimately resulting in the activation of various signal transduction cascades ( 2, 3 ). (aacrjournals.org)
  • Some FGFs are potent angiogenic factors, and most of them play important roles in embryonic development and wound healing ( 4, 5 ). (aacrjournals.org)
  • FGFs secreted by tumors act, on the one hand, in an autocrine manner promoting tumor growth, and, on the other hand, in a paracrine manner on endothelial cells, thereby promoting tumor angiogenesis ( 7 ). (aacrjournals.org)
  • In pancreatic cancer, high levels of several FGFs ( 1, 2 , 5 , 7 ) and most of the FGFRs have been observed, suggesting the presence of autocrine activation of receptors and of downstream signaling pathways ( 13 ). (aacrjournals.org)
  • Fibroblast growth factor receptor 4 (FGFR4), a tyrosine kinase receptor for FGFs, is involved in diverse cellular processes, including the regulation of cell proliferation, differentiation, migration, metabolism, and bile acid biosynthesis. (selleckchem.com)
  • Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. (pubmedcentralcanada.ca)
  • which suggests functional redundancy among different FGFs and possibly FGF receptors. (pubmedcentralcanada.ca)
  • To this end, gene expression profiling revealed frequent coexpression of specific fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in NSCLC cell lines. (aspetjournals.org)
  • FGFs stimulate diverse responses in development and tissue maintenance by binding to and activating a family of four receptor tyrosine kinases designated FGFR1 to FGFR4. (aspetjournals.org)
  • Fibroblast growth factor receptors (FGFRs) are one of the RTK families that belong to the immunoglobulin (Ig) superfamily [ 13 ]. (hindawi.com)
  • Alternative splicing of Ig-III occurs in FGFRs 1-3, creating IIIb and IIIc variants of the receptors with diverse ligand-binding specificities that are expressed in a tissue-specific manner [ 14 - 16 ]. (hindawi.com)
  • The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. (nature.com)
  • 2001), and iii) the detection of N-linked glycosylation on an overexpressed extracellular domain of human FGFR4 suggested that the function of this receptor might also be regulated by glycosylation, similar to what occurs with other FGFRs (Tuominen et al. (atlasgeneticsoncology.org)
  • Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers, making them attractive drug targets. (nature.com)
  • Fibroblast growth factor receptors (FGFRs) control crucial signalling pathways, which are responsible for numerous cellular functions, including proliferation and migration ( 6 ). (spandidos-publications.com)
  • Among FGF receptors (FGFR1 to 4) only FGFR1 was detected on isolated mouse osteoclasts, whereas all FGFRs were identified on mouse osteoblasts. (biomedsearch.com)
  • The interactions of FGF receptors (FGFRs) with eighteen signaling FGF ligands regulates cell proliferation, differentiation, shape, and movement ( Ornitz and Itoh, 2015 ). (biologists.org)
  • Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. (biologists.org)
  • BUFFALO, NY - Proteins called fibroblast growth factor receptors (FGFRs) have been implicated in the development of pancreatic cancer, which remains difficult to treat. (roswellpark.org)
  • Thus, FGF2, FGF9 and their respective high-affinity FGFRs comprise a growth factor autocrine loop that is active in a subset of gefitinib-insensitive NSCLC cell lines. (aspetjournals.org)
  • Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. (wikipedia.org)
  • FGFR2 is a receptor for fibroblast growth factor. (wikipedia.org)
  • There are four other members of the FGFR1 gene family: FGFR2, FGFR3, FGFR4, and Fibroblast growth factor receptor-like 1 (FGFRL1). (wikipedia.org)
  • The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. (nih.gov)
  • Structural and biochemical studies have shown that autophosphorylation of fibroblast growth factor receptor 1 (FGFR1) ( 7 , 8 ) and FGFR2 ( 9 ) are mediated by a sequential and precisely ordered intermolecular reaction that can be divided into three phases. (pnas.org)
  • Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial cells and stromal cells for maintenance of homeostasis in normal prostate tissue. (sigmaaldrich.com)
  • Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10 -deficient mice also exhibit impaired thymic growth. (jimmunol.org)
  • Gene targeting studies on FgfR2, which encompass both receptor isoforms, have given varying results with peri-implantation lethality at E4.5-E5.5 ( 23 ) to early embryonic lethality of embryos showing no limb buds and a defective placenta ( 24 , 25 ). (jimmunol.org)
  • Conclusions: The allosteric FGFR2 inhibitor RPT835 significantly impacts on growth of FGFR2-expressing TNBC. (aacrjournals.org)
  • FGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. (creativebiomart.net)
  • FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. (creativebiomart.net)
  • The interaction of the synthetic pentasaccharide AGA*IAM (GlcNS,6S-GlcA-GlcNS,3S,6S-IdoA2S-GlcNS,6S-Me) with the extracellular Ig2 domain of the fibroblast growth factor receptor (FGFR2) has been studied by NMR and computational methods. (csic.es)
  • Reverse transcription-PCR experiments and immunoblotting revealed that sensitive cell lines dominantly expressed COOH terminus-truncated fibroblast growth factor receptor 2 (FGFR2) splicing variants that were constitutively phosphorylated and spontaneously dimerized. (aacrjournals.org)
  • The K-sam gene was first identified as an amplified gene in human gastric cancer cell line KATO-III ( 6 , 7 ), and its product was later found to be identical to the bacteria-expressed kinase, or keratinocyte growth factor receptor (KGFR), and FGF receptor 2 (FGFR2). (aacrjournals.org)
  • Specific silencing of FGF2 reduced anchorage-independent growth of two independent NSCLC cell lines that secrete FGF2 and coexpress FGFR1 IIIc and/or FGFR2 IIIc. (aspetjournals.org)
  • By contrast, RO4383596 influenced neither signal transduction nor growth of NSCLC cell lines lacking FGF2, FGF9, FGFR1, or FGFR2 expression. (aspetjournals.org)
  • Stork T, Sheehan A, Tasdemir-Yilmaz OE, Freeman MR. Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes. (umassmed.edu)
  • The fibroblast growth factor (FGF) signaling pathway is a recognized target of cancer therapy. (aacrjournals.org)
  • The fibroblast growth factor (FGF) signaling pathway is essential for organogenesis, tissue homeostasis, repair, and injury-induced angiogenesis. (biologists.org)
  • Here, we examine the strategy of arming oncolytic HSV with a dominant-negative FGF receptor (dnFGFR) that targets the FGF signaling pathway. (aacrjournals.org)
  • Both SB-431542 and A-83-01 are effective in inhibiting the signaling pathway of TGFβ in rabbit subconjunctival fibroblasts. (arvojournals.org)
  • Activating mutations of fibroblast growth factor receptor-3 ( FGFR3 ) have been described in approximately 75% of low-grade papillary bladder tumors. (aacrjournals.org)
  • Little is known about fibroblast growth factor receptor 3 (FGFR3) immunoreactivity and the clinical significance it may possess with regard to BC. (spandidos-publications.com)
  • Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. (biologists.org)
  • In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small cell lung cancer (NSCLC) specimens. (biologists.org)
  • To develop new customized therapies for cancers that are dependent on FGFR3 activation, we have used this mouse model to evaluate a human monoclonal antibody (D11) with specificity for the extracellular ligand-binding domain of FGFR3, that recognizes both human and mouse forms of the receptor. (biologists.org)
  • Here, we show that D11 effectively inhibits signaling through FGFR3 in vitro , inhibits the growth of FGFR3-dependent FGF9-induced lung adenocarcinoma in mice, and reduces tumor-associated morbidity. (biologists.org)
  • The FGFR3 receptor tyrosine kinase represents an attractive target for therapy due to its role in several human disorders, including skeletal dysplasias, multiple myeloma, and cervical and bladder carcinomas. (muni.cz)
  • In cultured chondrocytes and murine limb organ culture, NF449 rescued FGFR3-mediated extracellular matrix loss and growth inhibition, which represent two major cellular phenotypes of aberrant FGFR3 signaling in cartilage. (muni.cz)
  • Similar to other receptor tyrosine kinases (RTKs), FGFR1-4 proteins are single-pass transmembrane receptors with extracellular ligand-binding domains and an intracellular tyrosine kinase domain. (nature.com)
  • A key regulator of the FGFR4 pathway is its co-receptor klotho-beta (KLB), a 130 kDa transmembrane protein that exhibits a more restricted expression profile in adipose, liver and pancreas tissues. (atlasgeneticsoncology.org)
  • 2010). This SNP changes Gly388Arg in the predicted FGFR4 transmembrane domain, resulting in enhanced stability of the activated receptor (Ingvarsen et al. (atlasgeneticsoncology.org)
  • Binding of fibroblast growth factors produces receptor dimerization, autophosphorilation and signal transduction. (atlasgeneticsoncology.org)
  • gene encoded protein is a member of the tyrosine kinase receptor superfamily with high affinity for peptides in signal transduction for mitogenesis, cellular differentiation, and embryogenesis. (thefreedictionary.com)
  • This work provides the first detailed mechanistic analysis of growth factor receptor clustering at the cell surface through signal transduction and endocytic trafficking. (biologists.org)
  • Ligand-mediated activation of receptor tyrosine kinases (RTKs) initiates a signal transduction cascade that leads to a broad spectrum of cellular responses including differentiation, proliferation, survival and migration. (biologists.org)
  • Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed, and monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2) have become standard therapy for HER2-positive GC. (hindawi.com)
  • Aberrant or oncogenic activation of receptor tyrosine kinase (RTK) is involved in carcinogenesis or tumor progression. (hindawi.com)
  • Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. (wikipedia.org)
  • Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. (wikipedia.org)
  • FGFR1-4 are cell surface membrane receptors that possess tyrosine kinase activity. (wikipedia.org)
  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. (rcsb.org)
  • Tyrosine autophosphorylation of receptor tyrosine kinases plays a critical role in regulation of kinase activity and in recruitment and activation of intracellular signaling pathways. (pnas.org)
  • In other words, the molecular mechanism underlying how one kinase (the enzyme) within the dimerized receptor specifically and sequentially catalyzes phosphorylation of tyrosine(s) of the other kinase (the substrate) is not yet resolved. (pnas.org)
  • However, increasing evidence from across the receptor tyrosine kinase field is now strong enough to make the study of nuclear growth factor receptors a major area of interest. (clinsci.org)
  • In many tissues in which soluble factors are implicated in development, these factors act on their target cells through tyrosine kinase receptors. (diabetesjournals.org)
  • These receptors frequently possess tyrosine kinase activity. (umassmed.edu)
  • Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. (umassmed.edu)
  • Mitogenic signaling of G protein-coupled receptors (GPCRs) can proceed via sequential epidermal growth factor receptor (EGFR) transactivation and extracellular signal-regulated kinase (ERK) phosphorylation. (aspetjournals.org)
  • Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase. (biomedsearch.com)
  • Armed oncolytic HSV expressing cytokines (e.g., granulocyte macrophage colony-stimulating factor, interleukin-12, and interleukin-18), prodrug-activating enzymes (e.g., thymidine kinase and cytosine deaminase), and other therapeutic transgene products have been shown to enhance the antitumoral effect ( 10 - 14 ). (aacrjournals.org)
  • AZD2171 directly inhibited the growth of two gastric cancer cell lines (KATO-III and OCUM2M), with an IC 50 of 0.15 and 0.37 μmol/L, respectively, more potently than the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib. (aacrjournals.org)
  • Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. (eurekaselect.com)
  • Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase inhibitors (TKIs) such as gefitinib exhibit limited activity in this cancer. (aspetjournals.org)
  • the EGFR is an attractive candidate for a receptor tyrosine kinase mediating autocrine growth in NSCLC. (aspetjournals.org)
  • The report provides comprehensive information on the Fibroblast Growth Factor Receptor 1 (Basic Fibroblast Growth Factor Receptor 1 or Fms Like Tyrosine Kinase 2 or Proto Oncogene c Fgr or CD331 or FLT2 or FGFR1 or EC 2.7.10.1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (marketresearch.com)
  • Additionally, the report provides an overview of key players involved in Fibroblast Growth Factor Receptor 1 (Basic Fibroblast Growth Factor Receptor 1 or Fms Like Tyrosine Kinase 2 or Proto Oncogene c Fgr or CD331 or FLT2 or FGFR1 or EC 2.7.10.1) targeted therapeutics development and features dormant and discontinued projects. (marketresearch.com)
  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. (mybiosource.com)
  • Also known as Fibroblast growth factor receptor homolog 1 (DmHD-38) (Protein heartless) (Tyrosine kinase 1) (dTk1). (mybiosource.com)
  • Also known as Fibroblast growth factor receptor homolog 2 (Protein breathless) (Tyrosine kinase 2) (dTk2) (Tyrosine kinase receptor HD-311) (dFGF-R1). (mybiosource.com)
  • This is also manifested by increased biological signaling, increased tyrosine phosphorylation, and in vitro kinase activity associated with dimeric receptors. (aacrjournals.org)
  • To evaluate the efficacy of activin receptor-like kinase (ALK) inhibitors in blocking the transforming growth factor-β (TGF-β) pathway in cultured rabbit subconjunctival fibroblasts. (arvojournals.org)
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. (wikipedia.org)
  • The development of the thymus has been shown to require the expression of a number of genes, including members of the Hox and Pax gene transcription factor families. (jimmunol.org)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. (gentaur.com)
  • To investigate the frequency and the prognostic impact of fibroblast growth factor receptor 1 (FGFR1) gene amplification in 526 curatively resected esophageal squamous cell carcinoma (ESCC). (unboundmedicine.com)
  • Gene arrays identified multiple direct targets of FGF10, including main transcription factors. (frontiersin.org)
  • Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME. (curehunter.com)
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Fibroblast growth factor receptor 4 is a protein encoded by the FGFR4 gene. (marketresearch.com)
  • In 1995, A.O.M. Wilkie published a paper showing evidence that acrocephalosyndactyly is caused by a defect on the fibroblast growth factor receptor 2 gene, on chromosome 10. (intelligentdental.com)
  • This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. (wikipedia.org)
  • This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization. (nih.gov)
  • An integrin-binding defective FGF1 mutant (Arg-50 to Glu, R50E) is defective in ternary complex formation and in inducing cell proliferation, migration and angiogenesis, while R50E still binds to the FGF receptor and heparin. (mdpi.com)
  • Collin-Osdoby P, Rothe L, Bekker S, Anderson F, Huang Y, Osdoby P. Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro. (umassmed.edu)
  • It successfully suppressed the growth, angiogenesis, and metastasis of two tumor cell lines in vitro and in vivo , and it potently inhibited cancer cell proliferation but not normal cell proliferation. (aacrjournals.org)
  • FGF signaling seems to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state ( 6 ). (aacrjournals.org)
  • In vivo , bG47Δ-dnFGFR was more efficacious than its nonexpressing parent bG47Δ-empty at inhibiting tumor growth and angiogenesis in both human U87 glioma and mouse 37-3-18-4 MPNST tumors in nude mice. (aacrjournals.org)
  • These data are consistent with potent inhibition of VEGF signaling, angiogenesis, neovascular survival, and tumor growth. (aacrjournals.org)
  • Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome. (jci.org)
  • Our previous studies showed significant activities of the dual VEGFR-2 and epidermal growth factor receptor inhibitor ZD6474 against poorly differentiated gastric cancer ( 11 ) and non-small-cell lung cancer with epidermal growth factor receptor mutations ( 12 , 13 ), both in vitro and in vivo . (aacrjournals.org)
  • Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I -- d'Avis et al. (aacrjournals.org)
  • Thanatophoric dysplasia type I (TDI) is a neonatal lethal skeletal dysplasia caused by several mutations in the extracellular domain of fibroblast growth factor receptor 3. (aacrjournals.org)
  • These results suggest that TDI is caused by Cys-mediated intermolecular disulfide bonding, leading to constitutive receptor activation as a result of these mutations. (aacrjournals.org)
  • Mutations causing TDI are discussed with respect to activating mutations in other receptors that are implicated in human disease. (aacrjournals.org)
  • Here we report our recent discovery, that in cooperation with platelet derived growth factor receptor (PDGFRβ), CDH11 regulate cell growth via the PDGFRβ-AKT axis. (aiche.org)
  • Interestingly, CDH11 engagement upregulated the expression of platelet derived growth factor receptor beta (PDGFRβ), as evidenced by shCDH11 knockdown in human fibroblasts and cdh11 -/- mouse cells. (aiche.org)
  • However, several agents targeting epidermal growth factor receptor (EGFR) provided no additional benefits in clinical trials [ 6 - 8 ]. (hindawi.com)
  • Although the μ-opioid receptor (MOR) mediates stimulation of ERK via EGFR transactivation in human embryonic kidney 293 cells, the mechanism of acute MOR signaling to ERK has not been characterized in rat C6 glioma cells that seem to contain little EGFR. (aspetjournals.org)
  • We propose that autocrine growth signaling pathways distinct from EGFR are active in NSCLC cells. (aspetjournals.org)
  • These newly phosphorylated sites bind cytosolic docking proteins such as FRS2, PRKCG and GRB2 which proceed to activate cell signaling pathways that lead to cellular differentiation, growth, proliferation, prolonged survival, migration, and other functions. (wikipedia.org)
  • The exact pathways and elements activated depend on the cell type being stimulated plus other factors such as the stimulated cells microenvironment and previous as well as concurrent history of stimulation Activation of the gamma isoforms of phospholipase C (PLCγ) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating pathways. (wikipedia.org)
  • Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias. (sciencemag.org)
  • It was demonstrated in vitro that both FGF1 and FGF2 induce the expression of NGFI-A mRNA, a useful indicator of functional growth factor-signaling pathways. (diabetesjournals.org)
  • Thus, a novel transactivation mechanism entailing secreted endogenous FGF may link the GPCR and growth factor pathways involved in MOR activation of ERK in C6 cells. (aspetjournals.org)
  • Endocytic trafficking controls the duration and intensity of signalling, and growth factor receptor signalling can lead to modifications of trafficking pathways. (biologists.org)
  • Although mAChR and FGFR1 activate common signaling pathways, playing similar roles in the regulation of central nervous system (CNS) plasticity and trophism, this analysis revealed that at the present there are no data reporting an involvement of cholinergic receptors in the FGFR1 transactivation. (eurekaselect.com)
  • The development of therapeutics targeting key signaling pathways important in human breast cancer, notably estrogen receptor (ER) and heregulin, has accounted for the recent decrease in mortality of several breast cancer subtypes ( 1 ). (pubmedcentralcanada.ca)
  • An inhibitor of vascular endothelial growth factor receptor 2 or MET has also produced promising results in patients with GC. (hindawi.com)
  • AZD2171 is an oral, highly potent, and selective vascular endothelial growth factor signaling inhibitor that inhibits all vascular endothelial growth factor receptor tyrosine kinases. (aacrjournals.org)
  • Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. (umassmed.edu)
  • The authors tried to determine whether human corneal endothelial cells in primary culture synthesize messenger RNA (mRNA) coding for epidermal growth factor (EGF), EGF receptor, basic fibroblast growth factor (FGFb), transforming growth factor beta-1 (TGFb1), and interleukin-1 alpha (IL-1 alpha). (arvojournals.org)
  • Using in situ hybridization on en face preparations, we were able to detect mRNA in luminal cells that was not observed by analysis of artery cross sections. (ahajournals.org)
  • The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. (wikipedia.org)
  • On a molecular level these signals mediate cell division, growth and differentiation. (wikipedia.org)
  • Description Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)
  • Inhibition of Fibroblast Growth Factor Receptor 3 Induces Differentiation and Apoptosis in t(4;14) Myeloma. (mayo.edu)
  • Fibroblast growth factors (FGF) and their signaling receptors have been found to be associated with multiple biological activities, including proliferation, differentiation, motility, and transforming activities ( 3 - 5 ). (aacrjournals.org)
  • The first electrochemical immunosensor for the determination of fibroblast growth factor receptor 4 (FGFR4) biomarker is reported in this work. (sigmaaldrich.com)
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) pipeline Target constitutes close to 26 molecules. (marketresearch.com)
  • It also reviews key players involved in Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics development with respective active and dormant or discontinued projects. (marketresearch.com)
  • Taken together, our results demonstrate a novel role of CDH11 in regulating fibroblast growth through synergistic interaction with PDGFRβ and suggest a novel mechanism that involves the physical interaction of CDH11 with a growth factor receptor and modulates its sensitivity to the ligands. (aiche.org)
  • The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. (mcw.edu)
  • Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (pnas.org)
  • Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. (biologists.org)
  • Shin M, Watanuki K, Yasugi S. Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. (umassmed.edu)
  • Our data demonstrate that fibroblast growth factor (FGF) receptors I and II are present in the developing gonad and are consistent with expression of these receptors by PGCs. (ovid.com)
  • cDNA cloning and developmental expression of fibroblast growth factor receptors from Xenopus laevis. (asm.org)
  • The effects of dnFGFR expression on cell growth and migration in vitro and tumor formation in vivo were determined. (aacrjournals.org)
  • cDNAs encoding a full-length receptor were isolated and RNA expression examined in adult and fetal tissues by RNA blot analysis. (biologists.org)
  • Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. (ahajournals.org)
  • The expression of connective tissue growth factor (CTGF), a TGF-β downstream mediator, was evaluated by Western blotting. (arvojournals.org)
  • Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2/ERBB2), was the first RTK-targeting agent approved for the indication of unresectable or metastatic GC worldwide [ 5 ]. (hindawi.com)
  • Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor- (VEGF-) A, which activates VEGF receptor- (VEGFR-) 1 and VEGFR-2, provided significant benefits in terms of progression-free survival (PFS), but not overall survival (OS) [ 9 ]. (hindawi.com)
  • This article describes the phage display identification of a novel fully human fibroblast growth factor receptor 1 (FGFR1c) targeting monoclonal antibody called R1c mAb. (moleculardevices.com)
  • Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. (nih.gov)
  • Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. (sigmaaldrich.com)
  • Do you have any of these conditions: Urothelial Cancer or Fibroblast Growth Factor Receptors? (centerwatch.com)
  • Electrochemical sensor for rapid determination of fibroblast growth factor receptor 4 in raw cancer cell lysates. (sigmaaldrich.com)
  • We have shown inhibitory activity of R3Mab on tumor growth and corresponding cell signaling in three different orthotopic xenografts of bladder cancer. (aacrjournals.org)
  • Generali, D. Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer. (preprints.org)
  • Autocrine growth factor production by cancer cells provides self-sufficiency in growth signals, one of the six hallmarks of cancer ( Hanahan and Weinberg, 2000 ). (aspetjournals.org)
  • 2007 ) in glioblastoma cell lines provides strong evidence for the coactivation of multiple receptor tyrosine kinases in cancer cells and the requirement for simultaneous blockade to achieve significant growth inhibition. (aspetjournals.org)
  • One such target, which has been implicated in the etiology of breast cancer, is the fibroblast growth factor (FGF) receptor. (pubmedcentralcanada.ca)
  • The tumor growth curve shows a nearly exponential increase in median tumor volume up to day 31 in the vehicle group and a high rate of slow growing tumors up to day 40 in the study group. (aacrjournals.org)
  • Oral administration of AZD2171 (1.5 or 6 mg/kg/d) significantly and dose-dependently inhibited tumor growth in mice bearing KATO-III and OCUM2M tumor xenografts. (aacrjournals.org)
  • Subconjunctival fibroblasts derived from New Zealand white rabbits were incubated with or without 2 ng/mL of TGF-β2 and treated with various concentrations of selected ALK inhibitors, SB-431542 and A-83-01, for 48 and 72 hours. (arvojournals.org)
  • Of particular importance is alternative splicing in the third immunoglobulin-like domain of FGFR1-3, which generates IIIb and IIIc variants of these receptors that are characterized by different ligand-binding specificities ( Ornitz and Itoh, 2001 ). (pubmedcentralcanada.ca)
  • However, we propose that the targets of armed oncolytic viruses should be expanded to include tumor stromal cells and vasculature to maximize the therapeutic effect, using fibroblast growth factor (FGF) as an example. (aacrjournals.org)
  • Further, they reveal protein translation initiation factors as potential therapeutic targets for human breast cancers with alterations in FGF signaling. (pubmedcentralcanada.ca)
  • Subsequently, these stem cells proliferate, rearrange their Ag receptor genes, and then differentiate into functionally mature T cells. (jimmunol.org)
  • This is associated with enhanced proliferation and anchorage-independent growth in vitro. (nih.gov)
  • Moreover, PGCs can bind radiolabeled bFGF in vitro, demonstrating that the factor can act directly on these cells. (ovid.com)
  • Growth factor receptors transmit biological signals for the stimulation of cell growth in vitro and in vivo and their autocrine stimulation may be involved in tumorigenesis. (diva-portal.org)
  • Specifically, engagement of CDH11 promotes fibroblast proliferation, while CDH11 deficiency decrease the proliferation rate significantly. (aiche.org)
  • Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (gentaur.com)
  • Release of endogenous basic fibroblast growth factor (bFGF) has been shown to initiate smooth muscle cell (SMC) proliferation following balloon catheter denudation in rat arteries. (ahajournals.org)
  • A new paper in Development investigates the roles of Fgf signalling and Tbx transcription factors in zebrafish muscle development. (biologists.org)
  • Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family. (umassmed.edu)
  • An alternative splicing event in FGFR1-3 involving the exon encoding the C-terminal region of D3 results in two otherwise identical receptors (b and c isoforms), possessing different ligand-binding specificities ( 8 - 10 ). (pnas.org)
  • A fibroblast growth factor receptor that is found in two isoforms. (curehunter.com)
  • One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. (curehunter.com)
  • A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. (curehunter.com)
  • The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. (rcsb.org)
  • The experiments presented in this report provide the molecular basis underlying the control of transphosphorylation of FGF receptors and other receptor tyrosine kinases. (pnas.org)
  • Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. (umassmed.edu)
  • We have employed embryoid bodies derived from murine embryonal stem cells to study effects on vascular development induced by fibroblast growth factor (FGF)-2 and FGF receptor-1, in comparison to the established angiogenic factor vascular endothelial growth factor (VEGF)-A and its receptor VEGF receptor-2. (diva-portal.org)
  • Childhood hypothyroidism causes delayed ossification and growth retardation, whereas thyrotoxicosis accelerates bone development, induces premature growth plate and skull suture closure and causes short stature and craniosynostosis. (endocrine-abstracts.org)
  • AZD2171 is a potent, ATP-competitive small molecule that inhibits all vascular endothelial growth factor receptors [VEGFR-1, VEGFR-2 (also known as KDR), and VEGFR-3]. (aacrjournals.org)
  • Nuclear receptors are less acknowledged as targets, largely due to historical scepticism as to their existence or importance. (clinsci.org)
  • We and others have previously identified basic fibroblast growth factor (bFGF) as a powerful mitogen in this system. (ovid.com)
  • Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells. (arvojournals.org)
  • The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. (biologists.org)
  • An intermediary role of FGFR1 transactivation was suggested by MOR- but not κ-opioid receptor (KOR)-induced FGFR1 tyrosine phosphorylation. (aspetjournals.org)
  • While mitotic PGCs of either sex are shown to bind radiolabeled bFGF, oogonia that are undergoing meiotic arrest exhibit reduced bFGF binding, indicating potential developmental regulation of an FGF receptor. (ovid.com)
  • Ligand-induced tyrosine autophosphorylation plays an important role in the control of activation and cell signaling by receptor tyrosine kinases ( 1 - 6 ). (pnas.org)
  • Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues. (sciencemag.org)
  • Exactly how the activation of the FGF receptors affects cell behaviour and leads to cell movement is not understood. (royalsocietypublishing.org)
  • In all cases, the presence of the mutant Cys residue allows the receptor to dimerize abnormally, resulting in ligand-independent activation. (aacrjournals.org)