The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
Any codon that signals the termination of genetic translation (TRANSLATION, GENETIC). PEPTIDE TERMINATION FACTORS bind to the stop codon and trigger the hydrolysis of the aminoacyl bond connecting the completed polypeptide to the tRNA. Terminator codons do not specify amino acids.
A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.
A process of GENETIC TRANSLATION whereby the terminal amino acid is added to a lengthening polypeptide. This termination process is signaled from the MESSENGER RNA, by one of three termination codons (CODON, TERMINATOR) that immediately follows the last amino acid-specifying CODON.
A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
Absence of hair from areas where it is normally present.
Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.
A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p100 precursor protein and is important for maturation of B-LYMPHOCYTES and adaptive HUMORAL IMMUNITY.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Tumors or cancer of the human BREAST.
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
A cell line derived from cultured tumor cells.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
The constricted portion of the thigh bone between the femur head and the trochanters.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
Breaks in bones.
Assistance in managing and monitoring drug therapy for patients receiving treatment for cancer or chronic conditions such as asthma and diabetes, consulting with patients and their families on the proper use of medication; conducting wellness and disease prevention programs to improve public health; overseeing medication use in a variety of settings.
In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Tumors or cancer of the PROSTATE.
Provision of physical and biological barriers to the dissemination of potentially hazardous biologically active agents (bacteria, viruses, recombinant DNA, etc.). Physical containment involves the use of special equipment, facilities, and procedures to prevent the escape of the agent. Biological containment includes use of immune personnel and the selection of agents and hosts that will minimize the risk should the agent escape the containment facility.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Coloration of the skin.
Irradiation directly from the sun.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. (1/1642)

Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.  (+info)

Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. (2/1642)

We are exploring the mechanism of action of the hormonal form of the nutrient vitamin D, 1,25(OH)2D3, and its cognate nuclear receptor at the level of gene control. In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation. Here, we will summarize some of our recent results from both tracks because a detailed understanding of how VDR functions as a ligand-regulated transcription factor will allow us to study its actions on these newly discovered genes more effectively.  (+info)

1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1). (3/1642)

Retinoic acid (RA) resistance is a serious problem for patients with acute promyelocytic leukemia (APL) who are receiving all-trans RA. However, the mechanisms and strategies to overcome RA resistance by APL cells are still unclear. The biologic effects of RA are mediated by two distinct families of transcriptional factors: RA receptors (RARs) and retinoid X receptors (RXRs). RXRs heterodimerize with 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (VDR), enabling their efficient transcriptional activation. The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1) has a vitamin D3-responsive element (VDRE) in its promoter, and 1,25(OH)2D3 enhances the expression of p21(WAF1/CIP1) and induces differentiation of selected myeloid leukemic cell lines. We have recently established a novel APL cell line (UF-1) with features of RA resistance. 1,25(OH)2D3 can induce growth inhibition and G1 arrest of UF-1 cells, resulting in differentiation of these cells toward granulocytes. This 1, 25(OH)2D3-induced G1 arrest is enhanced by all-trans RA. Also, 1, 25(OH)2D3 (10(-10) to 10(-7) mol/L) in combination with RA markedly inhibits cellular proliferation in a dose- and time-dependent manner. Associated with these findings, the levels of p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells. Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells. Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) transcripts were induced after 6 hours' exposure to 1,25(OH)2D3 and then decreased to basal levels over 48 hours. Western blot experiments showed that p21(WAF1/CIP1) protein levels increased and became detectable after 12 hours of 1,25(OH)2D3 treatment and induction of p27(KIP1) protein was much more gradual and sustained in UF-1 cells. Interestingly, the combination of 1, 25(OH)2D3 and RA markedly enhanced the levels of p27(KIP1) transcript and protein as compared with levels induced by 1, 25(OH)2D3 alone. In addition, exogenous p27(KIP1) expression can enhance the level of CD11b antigen in myeloid leukemic cells. In contrast, RA alone can induce G1 arrest of UF-1 cells; however, it did not result in an increase of p21(WAF1/CIP1) and p27(KIP1) transcript and protein expression in RA-resistant cells. Taken together, we conclude that 1,25(OH)2D3 induces increased expression of cdk inhibitors, which mediates a G1 arrest, and this may be associated with differentiation of RA-resistant UF-1 cells toward mature granulocytes.  (+info)

Vitamin D receptor 3'-untranslated region polymorphisms: lack of effect on mRNA stability. (4/1642)

Allelic variation at the 3'-end of the vitamin D receptor (VDR) gene has been associated with a 3-5-fold increased risk of developing prostate cancer and with differences in bone mineralization. This genetic diversity does not alter the VDR protein structurally, but instead may be a marker(s) of other, nearby polymorphisms that influence message stability or translation. The work reported here was instigated to identify additional VDR 3'-UTR polymorphisms that may have functional significance and to then test whether these genetic variants alter message stability. Initially, four novel, frequently occurring sequence variants were identified that associated with two common haplotypes that were described previously. These common sequence variants were not found within three message-destabilizing elements that we mapped within the 3'-UTR of the vitamin D receptor mRNA. Furthermore, the two VDR 3'-UTR haplotypes conferred an identical half-life on a heterologous beta-globin reporter gene, in an in vitro assay. We therefore conclude that common polymorphisms within the VDR 3'-UTR do not influence message stability.  (+info)

Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly. (5/1642)

Crystallographic structures of the ligand-binding domains for the retinoid X (RXR) and estrogen receptors have identified conserved surface residues that participate in dimer formation. Homologous regions have been identified in the human vitamin D receptor (hVDR). Mutating Lys-386 to Ala (K386A) in hVDR significantly reduced binding to glutathione S-transferase-RXRalpha in solution, whereas binding of an I384R/Q385R VDR mutant was almost undetectable. The K386A mutant formed heterodimers with RXRalpha on DR-3 (a direct repeat of AGGTCA spaced by three nucleotides), whereas the I384R/Q385R mutant completely eliminated heterodimer formation. Wild type hVDR effected a 3-fold induction of DR-3-dependent thymidine kinase-luciferase activity in cultured neonatal rat atrial myocytes, an effect that was increased to 8-9-fold by cotransfected hRXRalpha. Induction by K386A, in the presence or absence of RXRalpha, was only slightly lower than that seen with wild type VDR. On the other hand, I384R/Q385R alone displayed no stimulatory activity and less than 2-fold induction in the presence of hRXRalpha. Qualitatively similar findings were observed with the negative regulation of the human atrial natriuretic peptide gene promoter by these mutants. Collectively, these studies identify specific amino acids in hVDR that play a critical role in heterodimer formation and subsequent modulation of gene transcription.  (+info)

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (6/1642)

The human thyroid hormone receptor-associated protein (TRAP) complex, an earlier described coactivator for nuclear receptors, and an SRB- and MED-containing cofactor complex (SMCC) that mediates activation by Gal4-p53 are shown to be virtually the same with respect to specific polypeptide subunits, coactivator functions, and mechanisms of action (activator interactions). In parallel with ligand-dependent interactions of nuclear receptors with the TRAP220 subunit, p53 and VP16 activation domains interact directly with a newly cloned TRAP80 subunit. These results indicate novel pathways for the function of nuclear receptors and other activators (p53 and VP16) through a common coactivator complex that is likely to target RNA polymerase II. Identification of the TRAP230 subunit as a previously predicted gene product also suggests a coactivator-related transcription defect in certain disease states.  (+info)

Vitamin D receptor alleles predict growth and bone density in girls. (7/1642)

OBJECTIVES: Polymorphism of the vitamin D receptor (VDR), collagen alpha I type I (Col I alpha I), and oestrogen receptor (ER) genes have been shown to account for some of the heritability of bone mineral density (BMD) in adults. This study examined this relation in prepubertal children. METHODS AND SUBJECTS: The relation between genotypes of VDR gene (Taq I, Bsm I, Fok I), Col I alpha I gene (Msc I), and ER gene (Pvu II) with areal BMD, volumetric BMD, and growth were examined in 114 (68 girls) healthy 7 year old, white children. RESULTS: The genotype of the VDR gene (Taq I) correlated with lumbar spine (L1-4) volumetric BMD in girls only, but at no other bone sites. In girls, VDR genotype affected areal BMD at all sites. After adjusting for height and weight, however, this effect was explained completely by the independent effect of the VDR genotype on growth. Girls with genotype TT, were 3.9 kg heavier and 4.1 cm taller than those with tt, but this relation was not present at birth. No relation was found between genotypes of the VDR gene (Fok I), Col I alpha I gene (Msc I), or ER gene (Pvu II) and BMD or growth variables. CONCLUSIONS: In prepubertal girls, VDR alleles contribute to lumbar spine volumetric BMD variance, but the areal BMD effect reflects the relation between areal BMD and growth. VDR alleles might affect postnatal growth regulation.  (+info)

Structure-function studies of new C-20 epimer pairs of vitamin D3 analogs. (8/1642)

A growing number of calcitriol (1alpha,25-dihydroxyvitamin D3) analogs have become available in recent years. Many of these analogs exhibit lower calcemic effects than calcitriol and inhibit cell proliferation and enhance cell differentation more efficiently than calcitriol. We have compared structure-function relationships of a series of new C-20 epimer (20-epi) vitamin D3 analogs with their natural C-20 counterparts. In human MG-63 osteosarcoma cells, quantification of cellular osteocalcin mRNA levels by Northern blot analysis and osteocalcin biosynthesis by radioimmunoassay indicated that most studied analogs at a concentration of 10 nm induced osteocalcin gene expression more efficiently than the parent compound, calcitriol. Interestingly, when the biological responses were compared with the binding affinities of the analogs to in-vitro translated human vitamin D receptor and with their ability to protect the receptor against partial proteolytic digestion, significant correlations were not observed. Further, molecular modelling of the compounds by energy minimization did not reveal marked differences in the three-dimensional structures of the analogs. These results suggest that higher than normal ligand binding affinity or 'natural' conformation of the ligand-receptor complex are not necessarily required for the 'superagonist' transactivation activity. The mechanism of action of the efficient analogs may involve stabilization and/or differential binding of transcriptional coactivators or transcription intermediary factors to the hVDR during transactivation.  (+info)

OBJECTIVES: To investigate the possible association between vitamin D receptor genotype and bone mineral density in a large group of postmenopausal twins. DESIGN: Cross sectional twin study. SETTING: Twin population based in Britain. SUBJECTS: 95 dizygotic (non-identical) pairs of twins and 87 monozygotic (identical) pairs of twins aged 50-69 years, postmenopausal, and free of diseases affecting bone, recruited from a national register of twins and with a media campaign. MAIN OUTCOME MEASURES: Bone mineral density measured at the hip, lumbar spine, forearm, and for the whole body by dual energy x ray absorptiometry in relation to differences in the vitamin D receptor genotype. RESULTS: At all sites the values of bone density among dizygotic twins were more similar in those of the same vitamin D receptor genotype than in those of differing genotype, and the values in the former were closer to the correlations seen in monozygotic twins. Women with the genotype that made them at risk of osteoporotic
OBJECTIVES--To investigate the possible association between vitamin D receptor genotype and bone mineral density in a large group of postmenopausal twins. DESIGN--Cross sectional twin study. SETTING--Twin population based in Britain. SUBJECTS--95 dizygotic (non-identical) pairs of twins and 87 monozygotic (identical) pairs of twins aged 50-69 years, postmenopausal, and free of diseases affecting bone, recruited from a national register of twins and with a media campaign. MAIN OUTCOME MEASURES--Bone mineral density measured at the hip, lumbar spine, forearm, and for the whole body by dual energy x ray absorptiometry in relation to differences in the vitamin D receptor genotype. RESULTS--At all sites the values of bone density among dizygotic twins were more similar in those of the same vitamin D receptor genotype than in those of differing genotype, and the values in the former were closer to the correlations seen in monozygotic twins. Women with the genotype that made them at risk of osteoporotic
TY - JOUR. T1 - Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. AU - John, Esther M.. AU - Schwartz, Gary G.. AU - Koo, Jocelyn. AU - Wang, Wei. AU - Ingles, Sue A.. PY - 2007/12. Y1 - 2007/12. N2 - Considerable evidence indicates that vitamin D may reduce the risk of several cancers, including breast cancer. This study examined associations of breast cancer with sun exposure, the principal source of vitamin D, and vitamin D receptor gene (VDR) polymorphisms (FokI, TaqI, BglI) in a population-based case-control study of Hispanic, African-American, and non-Hispanic White women aged 35-79 years from the San Francisco Bay Area of California (1995-2003). In-person interviews were obtained for 1,788 newly diagnosed cases and 2,129 controls. Skin pigmentation measurements were taken on the upper underarm (a sun-protected site that measures constitutive pigmentation) and on the forehead (a sun-exposed site) using reflectometry. Biospecimens were ...
TY - JOUR. T1 - Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer. AU - John, Esther M.. AU - Schwartz, Gary G.. AU - Koo, Jocelyn. AU - Van Den Berg, David. AU - Ingles, Sue A.. PY - 2005/6/15. Y1 - 2005/6/15. N2 - Substantial experimental evidence indicates that the hormonal form of vitamin D promotes the differentiation and inhibits the proliferation, invasiveness, and metastasis of human prostatic cancer cells. Results from epidemiologic studies of vitamin D status and/or vitamin D receptor (VDR) polymorphisms and prostate cancer risk have been mixed. We conducted a population-based, case-control study of advanced prostate cancer among men ages 40 to 79 years from the San Francisco Bay area. Interview data on lifetime sun exposure and other risk factors were collected for 905 non-Hispanic White men (450 cases and 455 controls). Using a reflectometer, we measured constitutive skin pigmentation on the upper underarm (a sun-protected site) and facultative ...
Patients with insulin-dependent diabetes mellitus (IDDM) are at higher risk of developing osteoporosis. Among the genetic factors related to die development of osteoporosis, a possible association between vitamin D receptor (VDR) gene polymorphism and bone mineral density (BMD) has been described in some populations. We characterized the VDR gene polymorphism in a healthy adult Brazilian population and in a group of patients with IDDM and correlated these findings with densitometric values in both groups. the Brazilian population is characterized by an important racial heterogeneity and therefore is considered an ethnically heterogeneous population. We recruited 94 healthy adult Brazilian volunteers (63 women and 31 men), mean (+/- SD) age 32.4 +/- 6.5 years (range 18-39 years), and 78 patients with IDDM (33 women and 45 men) diagnosed before 18 years of age, mean (+/- SD) age 23.3 +/- 5.5 years (range 18-39 years). VDR genotype was assessed by polymerase chain reaction amplification followed by ...
Graves' (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms: BsmI, ApaI, TaqI, and FokI may predispose women with Graves' hyperthyroidism to BMD reduction or to disease development. The subjects were 75 premenopausal female Polish patients with GD and 163 healthy women. The genotyping was performed by the use of the restriction fragment length polymorphism analysis (RFLP). We studied the association of the VDR polymorphisms and their haplotypes with patients' BMD and also SNPs and haplotypes association with Graves' disease. We found a strong linkage disequilibrium for the BsmI, ApaI, and TaqI polymorphims that formed three most frequent haplotypes in Graves' women: baT (47.9%), ...
We conducted this study to examine the relationship between VDR expression and mutations in PIK3CA and KRAS in colorectal cancer. Accumulating evidence indicates a substantial role of vitamin D in prevention of various forms of human cancer (1, 2, 17, 36-38). A potential link between VDR and the PI3K-AKT or RAS-MAPK pathway has been suggested (17, 18). Thus, examining VDR in colorectal cancer may shed lights on biological mechanisms of vitamin D action and its failure. We have found that VDR overexpression in colorectal cancer is significantly associated with both PIK3CA and KRAS mutations independent of other clinical and molecular features. Our data support the hypothesis that the VDR pathway interacts with the PI3K-AKT and RAS-MAPK pathways in colonic neoplastic cells.. Our resource of a large number of colorectal cancers derived from the two prospective cohort studies has enabled us to precisely estimate the frequency of colorectal cancers with a specific molecular feature (such as VDR ...
PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation.
TY - JOUR. T1 - Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe. AU - Karami, S.. AU - Brennan, P.. AU - Hung, R. J.. AU - Boffetta, P.. AU - Toro, J.. AU - Wilson, R. T.. AU - Zaridze, D.. AU - Navratilova, M.. AU - Chatterjee, N.. AU - Mates, D.. AU - Janout, V.. AU - Kollarova, H.. AU - Bencko, V.. AU - Szeszenia-Dabrowska, N.. AU - Holcatova, I.. AU - Moukeria, A.. AU - Welch, R.. AU - Chanock, S.. AU - Rothman, N.. AU - Chow, W. H.. AU - Moore, L. E.. N1 - Funding Information: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, and by European Commission INCO-COPERNICUS grant IC15-CT96-0313. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention ...
Low levels of 25-hydroxy vitamin D (25(OH)D) and polymorphisms in the vitamin D receptor gene (VDR) have been found separately to increase risk of breast cancer. The aim of this study was to determine whether low 25(OH)D levels, alone and in combination with BsmI VDR genotype, increased breast cance …
Background In patients with advanced non-small-cell lung cancer, vitamin D receptor (VDR) polymorphisms and haplotypes are reported to be associated with survival. We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC). Methods In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 G/A (rs11568820), FokI C/T (rs10735810), BsmI A/G (rs1544410), ApaI G/T (rs7976091), and TaqI T/C (rs731236) were genotyped by sequencing in 204 consecutive patients with HNSCC who underwent tumor resection. Progression-free survival was compared between VDR polymorphisms using Kaplan-Meier survival curves with log-rank tests and Cox proportional hazard models adjusting for age, gender, smoking status, primary tumor sites, postoperative stages, existence of residual tumor, and postoperative treatment with chemotherapy or radiotherapy. Results During a median follow-up of 1,047 days, tumor progression and death
PATINO-GARCIA, Brenda et al. Association between polymorphisms of the androgen and vitamin D receptor genes with prostate cancer risk in a Mexican population. Rev. invest. clín. [online]. 2007, vol.59, n.1, pp.25-31. ISSN 0034-8376.. Introduction. Prostate cancer (PCa) is a worldwide health issue, because of its high incidence and mortality. Its etiology is complex and includes certain risk factors such as age, hormonal status, ethnic origin and family history of PCa. Genetic predisposition is proposed as a major risk factor and there are several controversial reports on the association of PCa and gene polymorphism such as the receptors of the androgen receptor (AR) and the vitamin D (VDR). Objective. To evaluate the CAG triplets repetitions in the first exon of the AR and polymorphisms in the restriction site Taql in the VDR in Mexicans with PCa. Material and methods. A total of 68 Mexicans with histopathological diagnosis of PCa and 48 healthy Mexican with normal prostate specific antigen and ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Prostate cancer is the most commonly diagnosed cancer in men, but rates around the world vary greatly. Americans have the highest incidence rates in the world, 4 to 5 times those of Spain. The hypothesis of this thesis was that vitamin D metabolism is a factor in prostate cancer development and the aim was to examine differences in factors that modulate vitamin D metabolism between the US and Spain, specifically sunlight exposure and vitamin D receptor (VDR) polymorphisms. Through a search of papers that examined sunlight exposure and prevalence of VDR polymorphisms, we found that Spain had more ultraviolet exposure than the United States, but there was little difference in proportions of VDR polymorphisms between the two populations. TaqI, BsmI, and FokI polymorphisms of the VDR were studied. Proportions of TaqI and FokI were found to be equivalent between the two populations. The rates of BsmI polymorphisms were found to be statistically different, but the United States, not Spain, has higher ...
Polymorphisms in the vitamin D receptor (VDR) gene may be of etiological importance in determining cancer risk. The aim of this study was to assess the association between common VDR gene polymorphism
TY - JOUR. T1 - Using components of the vitamin D pathway to prevent and treat colon cancer. AU - Stubbins, Renee E.. AU - Hakeem, Aisha. AU - Núñez, Nomelí P.. PY - 2012/12. Y1 - 2012/12. N2 - The objective of this review was to analyze the components of vitamin D and their potential usefulness in preventing and treating colorectal cancer. The active form of vitamin D, 1α,25(OH2)D3, targets the wnt/β-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Colorectal cell lines have shown that VDR expression levels decrease in the later stages of colon cancer. In colorectal cancers with low VDR expression, treatments to increase VDR expression could target alterations at the genomic and epigenomic levels by modulating transcription factors such as SNAIL1 and by utilizing histone deacetyltransferase inhibitors, respectively. Finally, epidemiological studies ...
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells. This regulation is mediated through interference with nuclear transcription factors such as NF-AT and NF-kappaB or by direct interaction with Vitamin D responsive elements in the promoter regions of cytokine genes. Dendritic cells (DCs) are primary targets for the immunomodulatory activity of 1,25(OH)(2)D(3), as indicated by inhibited DC differentiation and maturation, leading to down-regulated expression of MHC-II, costimulatory molecules and IL-12. Moreover, 1,25(OH)(2)D(3) enhances IL-10 production and promotes DC apoptosis. Together, these effects of 1,25(OH)(2)D(3) inhibit DC-dependent T cell activation. Immunomodulation by 1,25(OH)(2)D(3) and its analogs in vivo has been ...
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The Wnt-β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (DKK-1) gene encodes an extracellular Wnt inhibitor that blocks the formation of signalling receptor complexes at the plasma membrane. We report that 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the most active vitamin D metabolite, increases the level of DKK-1 RNA and protein in human SW480-ADH colon cancer cells. This effect is dose dependent, slow and depends on the presence of a transcription-competent nuclear vitamin D receptor (VDR). Accordingly, 1,25(OH)2D3 activates a 2300 bp fragment of the human DKK-1 gene promoter. Chromatin immunoprecipitation assays revealed that 1,25(OH)2D3 treatment induced a pattern of histone modifications which is compatible with transcriptionally active chromatin. DKK-1 is expressed at high level in colon cancer cell lines with a differentiated phenotype such as Caco-2 or HT-29. Exogenous expression of E-cadherin into SW480-ADH cells results in a strong adhesive phenotype and a ...
Vitamin D receptor (VDR) participates in multiple immune functions. Here, we determined whether VDR gene-sequence variations are associated with intersubject differences in the risk of acquiring human immunodeficiency virus type 1 (HIV-1) infection. We assessed this in 460 males exposed to HIV-1 by injection drug use (335 infected and 125 uninfected) and 124 seronegative healthy subjects. Multilocus logistic regression analysis revealed haplotypes for rs11568820, rs4516035, rs10735810, rs1544410, and rs17878969 polymorphisms showing association with protection to HIV-1 infection (odds ratio, 0.4 [95% confidence interval, 0.22-0.721; P = .0025), which remained significant after correction for multiple testing. We infer that VDR haplotypes might influence the risk of HIV-1 acquisition ...
Genome- and transcriptome-wide data has significantly increased the amount of available information about primary 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) target genes in cancer cell models, such as human THP-1 myelomonocytic leukemia cells. In this study, we investigated the genes G0S2, CDKN1A and MYC as master examples of primary vitamin D receptor (VDR) targets being involved in the control of cellular proliferation. The chromosomal domains of G0S2 and CDKN1A are 140-170 kb in size and contain one and three VDR binding sites, respectively. This is rather compact compared to the MYC locus that is 15 times larger and accommodates four VDR binding sites. All eight VDR binding sites were studied by chromatin immunoprecipitation in THP-1 cells. Interestingly, the site closest to the transcription start site of the down-regulated MYC gene showed 1,25(OH)2D3-dependent reduction of VDR binding and is not associated with open chromatin. Four of the other seven VDR binding regions contain a typical DR3-type VDR
Tacalcitol | VDR agonist | PRI 2191 | 1α,24-Dihydroxycholecalciferol | PRI2191 | CAS [57333-96-7] | Axon 2516 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
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Lee, Laura R. et al Progesterone Enhances Calcitriol Antitumor Activity by Upregulating Vitamin D Receptor Expression and Promoting Apoptosis in Endometrial Cancer Cells. Cancer Prevention Research (2013): . Web. 22 Feb. 2020. ...
We hypothesized that methylation of VDR may be population specific and that the combination of differential methylation and genetic variation may characterize tuberculosis (TB) predisposition. We use bisulfite conversion and/or pyrosequencing to analyze the methylation status of 17 CpGs of VDR and to genotype 7 SNPs in the 3 CpG Island (CpG island [CGI] 1060), including the commonly studied SNPs ApaI (rs7975232) and TaqI (rs731236 ...
19.70. Even though vitamins and supplements may seem completely natural and safe, that is not always the case for specific individuals. A standard multivitamin is okay for most people who take a supplement. Many supplements are advertised as being specially designed for men or for women or for certain age groups. Do sugar bear hair vitamins make hair shine, nails stronger, and help both to grow? Look for generic brands that contain the same amount of vitamins and minerals as the name brand. Recently, the association with vitamin b and pd is getting more and more attention. A few small clinical trials have tested the treatment effect of alpha-lipoic acid given either as a supplement or intravenously. However, some people benefit from taking a b-complex supplement. Can lysine, vitamin b-12, or other vitamins or minerals help prevent or reduce canker sores? Vitamin d modulates growth and differentiation of keratinocytes through binding to the nuclear vitamin d receptor (Vdr). As mentioned above, ...
1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signalling and replicated the findings in TCGA metastases. VDR expression was independently protective for melanoma death in both primary and metastatic disease. High tumor VDR expression was associated with upregulation of pathways mediating anti-tumor immunity and correspondingly with higher imputed immune cell scores and histologically detected tumor infiltrating lymphocytes (TILs). High VDR expressing tumors had downregulation of proliferative pathways, notably Wnt/beta-catenin signaling. Deleterious low VDR levels resulted from promoter methylation and gene deletion in metastases. ...
TY - JOUR. T1 - Involvement of vitamin D receptor in the intestinal induction of human ABCB1. AU - Tachibana, Shuko. AU - Yoshinari, Kouichi. AU - Chikada, Tsubasa. AU - Toriyabe, Takayoshi. AU - Nagata, Kiyoshi. AU - Yamazoe, Yasushi. PY - 2009/8. Y1 - 2009/8. N2 - ABCB1 (P-glycoprotein) is an efflux transporter that limits the cellular uptake levels of various drugs in intestine, brain, and other tissues. The expression of human ABCB1 has recently been reported to be under the control of nuclear receptor NR1I subfamily members, pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3). Here, we have investigated the involvement of another NR1I member, vitamin D receptor (VDR, NR1I1), in ABCB1 expression. In the human colorectal adenocarcinoma cell line LS174T, which abundantly expresses VDR, both 1α,25-dihydroxyvitamin D3 (1,25-VD3) and lithocholic acid (LCA) increased ABCB1 mRNA levels. Reporter gene assays in LS174T cells with constructs containing various lengths ...
We evaluated the role of VDR in the activation of the renin angiotensin system (RAS) in morphine-induced T cell loss. Morphine treated human T cells displayed down regulation of VDR and the activation of the RAS. On the other hand, a VDR agonist (EB1089) enhanced T cell VDR expression both under basal and morphine-stimulated states. Since T cells with silenced VDR displayed the activation of the RAS, whereas, activation of the VDR was associated with down regulation of the RAS, it appears that morphine-induced T cell RAS activation was dependent on the VDR status. Morphine also enhanced reactive oxygen species (ROS) generation in a dose dependent manner; however, this effect of morphine was inhibited by an opiate receptor antagonist, naltrexone. These findings confirmed the role of opiate receptors in morphine-induced ROS generation. Interestingly, the activation of VDR as well as blockade of Ang II (by losartan, an AT1 receptor blocker) also inhibited morphine-induced T cell ROS generation. ...
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Vitamin D Receptor ELISA Kits für viele Reaktivitäten. Chemical, Huhn, Rind (Kuh) und weitere. Vitamin D Receptor ELISA Kits vergleichen und bestellen.
The CC genotype of the vitamin D receptor (VDR) polymorphism TaqI rs731236 has previously been associated with a higher risk of developing myopathy compared to TT carriers. However, the mechanistic role of this polymorphism in skeletal muscle is not well defined. The effects of vitamin D on patients genotyped for the VDR polymorphism TaqI rs731236, comparing CC and TT carriers were evaluated. Primary human myoblasts isolated from 4 CC carriers were compared with myoblasts isolated from four TT carriers and treated with vitamin D in vitro. A dose-dependent inhibitory effect on myoblast proliferation and differentiation was observed concurrent with modifications of key myogenic regulatory factors. RNA sequencing revealed a vitamin D dose-response gene signature enriched with a higher number of VDR-responsive elements (VDREs) per gene. Interestingly, the greater the expression of muscle differentiation markers in myoblasts, the more pronounced was the vitamin D-mediated response to suppress genes ...
Serum calcium levels are tightly controlled by an integrated hormone-controlled system that involves active vitamin D [1,25(OH)2D], which can elicit calcium mobilization from bone when intestinal calcium absorption is decreased. The skeletal adaptations, however, are still poorly characterized. To gain insight into these issues, we analyzed the consequences of specific vitamin D receptor (Vdr) inactivation in the intestine and in mature osteoblasts on calcium and bone homeostasis. We report here that decreased intestinal calcium absorption in intestine-specific Vdr knockout mice resulted in severely reduced skeletal calcium levels so as to ensure normal levels of calcium in the serum. Furthermore, increased 1,25(OH)2D levels not only stimulated bone turnover, leading to osteopenia, but also suppressed bone matrix mineralization. This resulted in extensive hyperosteoidosis, also surrounding the osteocytes, and hypomineralization of the entire bone cortex, which may have contributed to the ...
Depression has been linked to (lack of) sunlight exposure and raised intracellular calcium levels. In this pathway, the role of the vitamin D pathway in calcium signaling in depression is shown. Active 1,25-dihydroxy-vitamin D3 is formed from 7-dehydrocholesterol by multiple conversion steps. It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. Less sunlight exposure results in lower 1,25-dihydroxyvitamin D3 levels and therefore higher calcium levels ...
The vitamin D receptor gene encodes the nuclear hormone receptor for vitamin D3 and belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. In light of evidence for promoter methylation of the vitamin D receptor in the control of the expression of this gene, we have designed methylation assays that cover many regions of this gene in order to determine its methylation profile in normal individuals, ovarian tumors and ovarian cell lines. We have isolated the DNA from ten tumor tissues and their adjacent normal tissue from four different tumor types; ovarian, breast, colon and cervical. By utilizing a combination of bisulfite sequencing, SNP genotyping, and expression analysis, we show ...
BioAssay record AID 602202 submitted by NCGC: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay.
BioAssay record AID 602200 submitted by NCGC: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay.
Here are some articles I found that illustrates 2 points - Firstly that there are other no pain no gain treatment protocols out there, in case anybody was doubting the wisdom of following MP. The term paradoxical pharmacology has been coined for these, and in one sense I think MP can join the list, after all it appears at first sight counter intuitive to make use of a VDR agonist (benicar) treatment when TH1 disease sufferers are already awash with a VDR agonist (1,25 D ...
I would like if someone send me information about vitamin D receptor localization in material fixed in 10% formalin and paraffin block. With compliments. Fernando Capela e Silva Departamento de Biologia Universidade de vora Apartado 94 7002-554 vora PORTUGAL Telephone: 266 760 881 Fax: 266 711 231 E-mail: [email protected] ...
2605 Background: Vitamin D receptors (VDR) are expressed on the surface of the epithelial ovarian cells and evidence from in vitro and animal models suggests an estrogen-dependent influence of VDR on female reproduction. We investigated the association of ovarian cancer risk with four polymorphisms in the VDR gene: the rs10735810 polymorphism (FokI) in the VDR promoter that alters the first start codon and three polymorphisms in the in 3 untranslated region, rs1544410 (BsmI), rs7975232 (ApaI) and rs731236 (TaqI), known to alter transcriptional activity and mRNA stability.. Methods:.Interviews and DNA samples were collected in a population-based case-control study of 313 women with epithelial ovarian carcinoma and 574 controls frequency-matched to cases on age and ethnicity. Genotyping was performed with the 5 nuclease discrimination assay. The associations of these genetic polymorphisms with ovarian carcinoma risk and their interaction with other hormone-related risk factors were studied using ...
P53 and its family members have been implicated in the direct regulation of the vitamin D receptor (VDR). Vitamin D- and p53-signaling pathways have a significant impact on spontaneous or carcinogen-induced malignant transformation of cells, with VDR and p53 representing important tumor suppressors. VDR and the p53/p63/p73 proteins all function typically as receptors or sensors that turn into transcriptional regulators upon stimulus, with the main difference being that the nuclear VDR is activated as a transcription factor after binding its naturally occurring ligand 1,25-dihydroxyvitamin D with high affinity while the p53 family of transcription factors, mostly in the nucleoplasm, responds to a large number of alterations in cell homeostasis commonly referred to as stress. An increasing body of evidence now convincingly demonstrates a cross-talk between vitamin D- and p53-signaling that occurs at different levels, has genome-wide implications and that should be of high importance for many malignancies,
SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections. The influence of genetic variation in the vitamin D pathway resulting in susceptibility to upper respiratory infections (URI) has not been investigated. We evaluated the influence of thirty-three SNP in eleven vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4, CYP27A1, LRP2, CUBN and VDR) resulting in URI risk in 725 adults in London, UK, using an additive model with adjustment for potential confounders and correction for multiple comparisons. Significant associations in this cohort were investigated in a validation cohort of 737 children in Manchester, UK. In all, three SNP in VDR (rs4334089, rs11568820 and rs7970314) and one SNP in CYP3A4 (rs2740574) were associated with risk of URI in the discovery cohort after adjusting for potential confounders and correcting for multiple comparisons (adjusted incidence rate ratio per additional minor allele ≥1·15, Pfor trend ...
Abstract: DESCRIPTION (provided by applicant): Investigations in this proposal are focused on identifying the molecular basis for the ligand dependent and independent actions of the VDR, using the skin as a model system. Like humans with VDR mutations, VDR null mice develop alopecia. We have demonstrated that the ligand-independent actions of the VDR are required for hair follicle keratinocyte stem cell (KSC) function, normal hair cycling and canonical Wnt (cWnt) signaling in keratinocytes. Interfering with cWnt signaling also impairs KSC function. Studies examining the interactions of the VDR with effectors of canonical Wnt signaling demonstrate that the VDR interacts with Lef1 via its DNA binding domain and that the VDR interacting domain of Lef1 is independent of its ¿-catenin binding domain. We will examine the functional consequences of impairing VDR-Lef1 interactions in keratinocytes and determine if the interaction between these two proteins is direct, or involves additional factors. ...
Duffy, MM,McNicholas, BA,Monaghan, DA,Hanley, SA,McMahon, JM,Pindjakova, J,Alagesan, S,Fearnhead, HO,Griffin, MD (2014) Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney. American Journal Of Physiology-Renal Physiology, 307 :1412-1426 [DOI] [Details] ...
BioTek 应用手册, 12/13 2017, An Image-Based Method to Detect and Quantify T Cell Mediated Cytotoxicity of 2D and 3D Target Cell Models
Results: No significant differences were observed for the VDR FokI, VDR Tru9I, VDR TaqI,, PTH DraII, INSR NsiI, and INSR PmlI gene polymorphisms between the women with PCOS and controls. However, after adjustment for confounding factors, the VDR BsmI Bb genotype and the VDR ApaI Aa genotype were significantly under transmitted to the patients (p= 0.016; OR= 0.250; 95% CI= 0.081-0.769, and p= 0.017; OR= 0.260; 95% CI= 0.086-0.788, respectively). Furthermore, in the women with PCOS, insulin levels were lower in the participants with the INSR NsiI NN genotype compared with those with the Nn + nn genotypes (P= 0.045 ...
Abstract Aim: Serum osteocalcin was shown in a previous study on first trimester pregnant women to correlate with bone density and to distinguish between fast and slow bone losers. The objective of the present study is to examine whether serum osteocalcin is related to vitamin D receptor (VDR) BsmI polymorphism in pregnant women. Study design: We determined osteocalcin serum levels and VDR BsmI genotype in 97 healthy first trimester pregnant women consecutively recruited during six months. Results: BB (21%), Bb (38%) and bb (41%) genotypes showed similar osteocalcin serum levels. However, in primigravidas (ns38) the BB genotype was significantly associated with higher mean osteocalcin level (9.67 ng/mL) than the Bb (8.07 ng/mL) and the bb genotype (8.14 ng/mL), respectively (P-0.05). The VDR genotype was the only independent parameter to correlate with serum osteocalcin (P-0.05). Conclusion: Only primigravidas show in the first trimester a relation between the bone formation parameter serum ...
Purpose : To investigate the effects on Vitamin D Receptor (VDR) knockout and 1,25- and 24,25-dihyroxyvitamin D3 (Vit D3) on cultured mouse corneal epithelial cell proliferation and on the Vit D activating enzyme CYP27B1 and inactivating enzyme CYP24A1. We also examined effects of vitamin D on mouse corneal epithelial intracellular calcium levels. Methods : Cultured mouse corneal epithelial cell (MCEC) proliferation was measured by reduction of MTT, which corresponds to the living cell number and metabolic activity. Total RNA and protein were isolated from mouse corneas and cultured mouse primary corneal epithelial cells. Transcript levels of CYP24A1 and CYP27B1 were assessed by qPCR, and Western blotting was used to detect CYP24A1 and CYP27B1 protein levels. Corneal epithelial calcium levels were recorded in excised, ex vivo mouse corneas using the calcium-sensitive dye Cal-520® and multi-photon microscopy. Results : 24,25-Vit D3 (50 nM) significantly increased proliferation in corneal ...
The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. The anticarcinogenic activity of the active form of Calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. Vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. VDRs selectively bind 1,25-(OH)2-D3 and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. VDRs are ligand-activated transcription factors. The receptors activate or repress the transcription of target genes upon binding their respective ligands. It is thought that the anticarcinogenic effect of Calcitriol is mediated via VDRs in cancer cells. The immunomodulatory activity of calcitriol is thought to be mediated by vitamin D receptors (VDRs) which are expressed constitutively in monocytes ...
Vitamin D endocrine system and osteoblasts.: The interaction between vitamin D and osteoblasts is complex. In the current review we will give an overview of the
BACKGROUND: Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients. METHODS: A total of 155 chronic hepatitis C patients were recruited from the Swiss Hepatitis C Cohort Study for NR1I1 genotyping and plasma 25-OH vitamin D level measurement. NR1I1 genotype data and combined effects of plasma 25-OH vitamin D level were analysed regarding therapy response (sustained virological response). RESULTS: A strong association was observed between therapy non-response and the NR1I1 CCA (bAt) haplotype consisting of rs1544410 (BsmI) C, rs7975232 (ApaI) C and rs731236 (TaqI) A alleles. Of the HCV patients carrying the CCA haplotype, 50.3% were non-responders (odds ratio [OR] 1.69, 95% CI 1.07, 2.67; P=0.028). A ...
TY - JOUR. T1 - Normal vitamin D receptor concentration and responsiveness to 1,25-dihydroxyvitamin D3 in skin fibroblasts from patients with absorptive hypercalciuria. AU - Zerwekh, J. E.. AU - Reed, B. Y.. AU - Heller, H. J.. AU - Gonzalez, G. B.. AU - Haussler, M. R.. AU - Pak, C. Y C. PY - 1998/1/1. Y1 - 1998/1/1. N2 - To evaluate whether there is an increase in vitamin D receptor (VDR) concentration which could raise intestinal calcium absorption in absorptive hypercalciuric (AH) patients and promote hypercalciuria, we measured VDR concentration and VDR mRNA levels in skin fibroblasts from 16 patients with AH and 17 age-matched normal subjects before and following a 16-hour incubation in the presence of 10-8 M 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. There were no significant differences in VDR concentration between normal subjects and AH patients in the basal state (30 ± 11 vs. 30 ± 15 ng/mg protein, respectively) or following 1,25(OH)2D3-mediated upregulation (43 ± 18 vs. 42 ± 16 ng/mg ...
In a 12-week randomized controlled trial ( double-blind study), based on data on serum 25(OH)D changes from other studies (35), to achieve 1 standard deviation difference in circulating 25(OH)D with two-sided alpha of 0.05 and a beta of 0.2 after a 12-week intervention period, the sample size was calculated 40 individuals per treatment group. Considering 3 polymorphic variant groups and one control group which receives plain yogurt drink, 160 subjects are needed. Allowing for 10% attrition over 12 weeks of intervention, a total of 180 subjects are required. In treatment groups, all patients receive 500 ml per day of low-fat (1%) Yogurt Drink fortified with approximately 500IU of vitamin D3 . Control group receives 500 ml per day of plain (unfortified) Yogurt Drink. Metabolic, inflammatory and oxidative stress markers are evaluated at the beginning and in the end of the interventional period ...
Vitamin D is produced in the skin upon sun-exposure or obtained through the diet. Vitamin D is hydroxylated to 25-hydroxyvitamin D (25(OH)D) in the liver and to the active form 1,25-dihydroxyvitamin D (1,25(OH) 2 D) in the kidneys. To exert its effect 1,25(OH) 2 D has to bind to the nuclear vitamin D receptor VDR. Lack of vitamin D leads to rickets in children and to osteomalacia in adults. 25(OH)D is used as a marker of a subjects vitamin D status. Low serum 25(OH)D levels are associated with a number of diseases, risk factors for disease and increased mortality ...
TY - JOUR. T1 - Vitamin D receptor quantitation in human blood mononuclear cells in health and disease. AU - Zerwekh, J. E.. AU - Yu, X. P.. AU - Breslau, N. A.. AU - Manolagas, S.. AU - Pak, C. Y C. PY - 1993/10. Y1 - 1993/10. N2 - Vitamin D receptor (VDR) concentration was quantitated in human peripheral blood mononuclear cells (PBMC) from patients with absorptive hypercalciuria (AH) and patients with high 1,25(OH)2D3 due to acquired or transient disease states and the results compared to those in normal subjects. VDR concentration in resting cells was not different between the three groups and represented constitutive receptor expression of monocytes. Following activation with phytohemagglutinin, patients with hypercalcitriolemia demonstrated significantly greater VDR concentrations. Patients with AH demonstrated a normal value for the group, but 6 patients had significantly greater concentrations of VDR despite normal plasma 1,25(OH)2D3 in four of the patients. Proliferation, as assessed ...
The researchers explain that vitamin D intake and serum concentrations of its metabolites have been associated with a decreased risk of developing breast cancer. The vitamin plays a known role in controlling calcium levels and influences the differentiation of cells and so could play a part in preventing the runaway proliferation of cells characteristic with cancer.. Previous studies regarding the association between vitamin D and breast cancer have been inconsistent in their conclusions.. Chang-Claude and her colleagues have investigated variations in the gene encoding the vitamin D receptor protein. They found that there were no differences in the biomarker for vitamin D, 25-hydroxyvitamin D, between women with two well-known genetic variations, the polymorphisms FokI and TaqI, and two functional putative variants, VDR-5132 and Cdx2, in the gene for the receptor. Moreover, they found no relationship between the presence of these polymorphisms and overall risk of postmenopausal breast ...
In an unrelated vitamin D study, researchers have identified vitamin D receptors (VDR) on 2776 gene positions and also found 229 genes that were activated in response to vitamin D. Vitamin D receptors are proteins that become activated by vitamin D. Activated VDR can then attach to specific sites on DNA which result in the expression of certain gene traits and/or genetic products such as enzymes. VDR binding sites were densely populated near autoimmune and cancer associated genes which may imply the importance vitamin D can play in autoimmune disease and cancer prevention. ...
Osteosarcoma (OS) is the most common type of bone cancer in children and adolescents. With the current treatment approaches, the survival rate is 60-70%. Therapies for treating OS have remained the same over the past thirty years. There is a need for developing more effective therapies, which can significantly improve the survival of the patients who do not respond well to current therapeutic strategies. Epidemiological evidence indicates impaired regulation of cell proliferation and survival appears to be a key event in the etiology of the disease. Previous in vitro and in vivo studies suggest that 1α,25-dihydroxyvitamin D3 (calcitriol or 1,25D) has significant antineoplastic activity by inhibiting cell proliferation and inducing differentiation and apoptosis in breast, prostate, colon, skin, and brain cancer. The molecular mechanisms for calcitriol-mediated cancer prevention are still unknown. In particular, the role of calcitriol in modulating OS needs to be investigated. The primary ...
The research team, which included scientists from the University of Medicine and Dentistry of New Jersey and Stanford University, noted after vitamin D binds to the receptor, also blocks a protein called NFAT needed to turn on the gene. Without the gene on, levels of IL-17 fall. Vitamin D also does another job by turning on a gene that produces suppressive T cells to fight destructive IL-17-production that occurs elsewhere.. According to the authors, in mouse models with EAE, vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] diminishes paralysis and progression of the disease and reduces IL-17A-secreting CD4+ T cells in the periphery and central nervous system (CNS).. Identification of the vitamin D pathway could lead to new treatments not only for multiple sclerosis, but for other autoimmune diseases include type 1 diabetes, rheumatoid arthritis and skin disorders. The authors concluded, Our results describe novel mechanisms and new concepts with regard to vitamin D and the immune system ...
Leica BLK3D Target Calibration Plate 877100 - Leica BLK3D Target Calibration Plate Target Calibration Plate for BLK3D: Size A3 Used for checking and adjusting the BLK3D.
Calcitriol Receptors: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
June 21 (Sunday) 14:00~ Registration 15:30~15:50 ,Ocean Hall, Opening Opening Remarks: F. Peter Guengerich (Vanderbilt University School of Medicine) 15:50-16:45 Plenary Lecture ,Ocean Hall, Shigeaki Kato (University of Tokyo): Nuclear vitamin D receptor-regulated expression of the human CYP27B1 gene mediates the DNA methylation/demetylation Session 1 Bioinformatics Chairs: Osamu Gotoh, Daniele Werck-Reichhart S1-L1: 17:00-17:30 Osamu Gotoh (Kyoto University): Birth and death of P450 genes in metazoan S1-L2: 17:30-18:00 Daniele Werck-Reichhart (CNRS-University, de Strasbourg): P450 evolution and neofunctionalization in plants: emergence of a novel phenolic pathway in Brassicaceae S1-L3: 18:00-18:30 Jongsun Park (Seoul National University): Integrated bioinformatics platforms for identifying and analyzing cytochrome P450s from diverse genomic resources S1-L4: 18:30-19:00 Masanori Arita (University of Tokyo): Data management of cross-disciplinary June 22 (Monday) 9:00~13:00 , Summit Hall , Session ...
Nuclear receptors are the central components of the complex signaling processes mediated by nuclear hormones. The specific interaction of a nuclear receptor, such as the VDR, with response elements of promoter regions determines which genes will be regulated by the respective nuclear hormone (i.e., in the case of VDR, which genes are primary VD-responding genes). The complex formation between VDR-RXR heterodimers and their specific VDREs is therefore a central molecular step in the specific activation of VD-responding genes. Investigation of the selective modulation of this complex formation on different types of VDREs by VDR ligands was therefore the subject of this study.. The selective biological profile of EB1089 [i.e., its potent antiproliferative potential combined with a reduced calcemic effect (Nayeri et al., 1995; Danielsson et al., 1997)] was associated with the higher selectivity (approximately 15-fold) of the analogs to activate IP9-type VDREs than DR3-type VDREs (Nayeri et al., ...
Results Clinical signs and symptoms of chronic arthritis were aggravated in hTNFtg mice lacking functional VDR signalling. Moreover, synovial inflammation was clearly increased in VDR−/−hTNFtg mice as compared to hTNFtg mice and was associated with an increased macrophage influx in inflamed joints. In vitro, VDR-deficient monocytes were proinflammatory and hyper-responsive to TNF stimulation associated with prolonged mitogen-activated protein kinase activation and cytokine secretion. Also, VDR−/− monocytes showed enhanced potential to differentiate into bone resorbing osteoclasts in vitro. In line, VDR−/−hTNFtg mice had significantly increased cartilage damage and synovial bone erosions.. ...
AB - A fundamental dilemma of steroid hormone regulation is how specific transcription is attained in vivo when several receptors recognize the same DNA sequence in vitro. We have identified an enhancer of the mouse sex-limited protein (Slp) gene that
Within the human digestive tract is a teeming mass of hundreds of types of bacteria, a potpourri of microbes numbering in the trillions that help us digest food and keep bad bacteria in check.
Calcitriol ,Calcitriol manufacturer,Calcitriol CAS No 32222-06-3,Calcitriol Molecular Formula C27H44O3,Calcitriol Synonyms (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol,Calcitriol Molecular weight 416.64 g/mol,Calcitriol manufacturing by A.S.Joshi & Company
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Meta-analysis is a statistical approach that combines the results of multiple scientific studies. Although many genetic studies have been conducted to discovery genetic risk factors for T1D, combining the results from these separated studies by using meta-analysis could lead to a higher statistical power and more robust point estimate. In this study, meta-analysis was performed on seven T1D case/control bio-sets extracted from four recent studies. T1D target genes from meta-analysis were sorted by gene score, which is based on the statistical significance and consistency of the gene across the queried bio-sets. Meta-analysis results suggested six top risk genes for T1D (Score ≥ 85), and four of them are novel according to a recently updated database T1D_GD. Further analyses were conducted to study the possible correlation between T1D and these six genes, with more efforts focused on the four novel ones.. Analysis using T1D_GD showed that the two known T1D target genes, HLA-DQB1 and OAS1, are ...
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Of in the blood interfere with vitamin D receptor binds to beneficial minerals such as heart disease and stroke. People of south Asian, Chinese, African-Caribbean or Middle Eastern descent are at higher risk for developing type 2 diabetes and gastrointestinal tract.. This helps increase stability and reactivity in extracts, the synergy in herbs and supplements as being practically important.. ...
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FGF23-null mice have a short lifespan and develop features resembling premature ageing. This appears to be a vitamin D-mediated process similar to that observed in klohto (KL) mice [1853]. KL has been shown to be an essential cofactor for activation of FGF signaling by FGF23 [1851]. Though inconclusive at present, FGF23 might play some role in ageing. ...
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Carrillo-López N, Fernández-Martín JL, Cannata-Andía JB (2009-04-01). "[The role of calcium, calcitriol and their receptors in ... There are two types of PTH receptors. Parathyroid hormone 1 receptors, activated by the 34 N-terminal amino acids of PTH, are ... Free OPG competitively binds to RANKL as a decoy receptor, preventing RANKL from interacting with RANK, a receptor for RANKL. ... Parathyroid hormone 2 receptors are present at high levels on the cells of central nervous system, pancreas, testes, and ...
Beer, TM; Myrthue, A. Calcitriol in the treatment of prostate cancer. Anticancer research. 2006, 26 (4A): 2647-51. PMID ... Buyru, N; Tezol, A; Yosunkaya-Fenerci, E; Dalay, N. Vitamin D receptor gene polymorphisms in breast cancer. Experimental & ... Associations Between Polymorphisms in the Vitamin D Receptor and Breast Cancer Risk. Cancer Epidemiology, Biomarkers, & ...
Type 2 (calcitriol receptor mutation). *Hypocalcemia-related rickets *Hypocalcemia. *Chronic renal failure (CKD-BMD) ...
See also: Vitamin D receptor and Calcitriol. Calcitriol enters the target cell and binds to the vitamin D receptor in the ... The vitamin D receptor belongs to the nuclear receptor superfamily of steroid/thyroid hormone receptors, and VDRs are expressed ... The active vitamin D metabolite calcitriol mediates its biological effects by binding to the vitamin D receptor (VDR), which is ... Calcifediol is then converted by the kidneys to calcitriol, the biologically active form of vitamin D. Calcitriol circulates as ...
The binding affinity of ercalcitriol to the vitamin D receptor is similar to that of calcitriol. Ergocalciferol itself and ... which activates the vitamin D receptor. Unlike cholecalciferol, 25-hydroxylation is not performed by CYP27A1 for ergocalciferol ...
If the tumor cannot be located, treatment with calcitriol (1-3 µg/day) and phosphorus (1-4 g/day in divided doses) is ... Some of the tumors express somatostatin receptors and may be located by octreotide scanning. A phosphaturic mesenchymal tumor ... Resection of the tumor is the ideal treatment and results in correction of hypophosphatemia (and low calcitriol levels) within ... FGF23 (fibroblast growth factor 23) inhibits phosphate transport in the renal tubule and reduces calcitriol production by the ...
... has been shown to interact with Estrogen receptor alpha, Cyclin-dependent kinase 8, Calcitriol receptor and BRCA1. GRCh38 ... Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (Jul 1998). "The TRAP220 component of a thyroid hormone receptor- associated ... Wang Q, Sharma D, Ren Y, Fondell JD (Nov 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor- ... Fondell JD, Ge H, Roeder RG (Aug 1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator ...
"Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in ... Ca2+ oscillations originate from the repetitive opening of the inositol 1,4,5-trisphosphate (InsP3) receptors that are Ca2+ ...
In mice in which the vitamin D receptor is not expressed, S100G is less abundant, but not absent.[citation needed] Vitamin D- ... Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol. They were found to exist ... Expression of S100G, like that of calbindin 1, is stimulated by the active vitamin D metabolite, calcitriol although the ...
... has been shown to interact with: Androgen receptor, C-Raf, Calcitriol receptor, Glucocorticoid receptor, HSPA8, HBEGF, ... "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. ... 1997). "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death". EMBO J. 15 (22): 6205-12. doi: ... Effects on androgen receptor transcriptional activity". J. Biol. Chem. 276 (16): 12718-24. doi:10.1074/jbc.M010841200. PMID ...
It is usually seen in cases of chronic kidney disease or defective calcium receptors on the surface of parathyroid glands.[ ... such as calcitriol, doxercalciferol, paricalcitol; and phosphate binders, which are either calcium-based and non-calcium based ...
Calcium-sensing membrane receptors in the parathyroid gland monitor calcium levels in the extracellular fluid. Low levels of ... Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D3. It has numerous functions involved in blood ... Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. It follows that an ... Bisphosphonates, RANKL inhibitors, SERMs-selective oestrogen receptor modulators, hormone replacement therapy and calcitonin ...
Some forms of vitamin D, such as calcitriol, are steroid-like and bind to homologous receptors, but lack the characteristic ... Mammalian steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, ... Phosphorylase activated, indicating that norepinephrine's target receptor was on the cell membrane, not located intracellularly ...
"Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α- ... Vitamin D5 is a form of vitamin D. Calcitriol (Vitamin D3) analogues have been proposed for use as antitumor agents. Studies on ... "Androgen Receptor Regulation of Vitamin D Receptor in Response of Castration-Resistant Prostate Cancer Cells to 1α- ... The motive to develop 1α-Hydroxyvitamin D5 stemmed from the tendency of calcitriol, or 1,25 dihydroxy vitamin D3, a natural ...
... calcitriol, performs its function through interactions with the calcitriol receptor. This nuclear hormone receptor is ... This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol is readily absorbed into the ... Eldecalcitol is an orally administered drug to patients, which binds to vitamin D receptors and binding protein for the goal of ... The chemistry of eldecalcitol allows for its binding 2.7-fold more potently than calcitriol. In addition, some vitamin D ...
Calcitriol receptor, Cyclin-dependent kinase 8 Estrogen receptor alpha, Gli3, G9a, PPARGC1A, MED26, SOX9, and Thyroid hormone ... Wang Q, Sharma D, Ren Y, Fondell JD (Nov 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor- ... Fondell JD, Ge H, Roeder RG (Aug 1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator ... interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor ...
... calcitriol receptor mutation) Hypocalcemia-related rickets Hypocalcemia Chronic renal failure (CKD-BMD) Hypophosphatemia- ...
Oxyphil cells have significantly more Calcium-sensing receptors (CaSRs) than chief cells. More work needs to be done to fully ... and calcitriol. Oxyphil cells have also been shown to have higher oxidative and hydrolytic enzyme activity than chief cells due ...
The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of ... It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25- ... Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, a kidney enzyme that converts calcifediol to calcitriol. Coulston AM, Boushey C, ...
Calcitriol receptor GFI1, Nuclear receptor co-repressor 1, Nuclear receptor co-repressor 2, PRKAR2A, and Zinc finger and BTB ... receptor". Cancer Res. 62 (23): 7050-8. PMID 12460926. McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S ...
Calcifediol is subsequently converted by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase to calcitriol, the active form ... of vitamin D3 which binds to the vitamin D receptor (VDR) and mediates most of the physiological hormonal actions of vitamin D ...
They discovered that calcitriol receptors are found throughout the body, and Mawer worked on developing assays for vitamin D ... they cannot produce calcitriol. Mawer was promoted to senior research fellow in 1974, and she became a "North West Regional ...
... as active as the calcitriol in regulating calcium metabolism. The vitamin D receptor belongs to the steroid/thyroid receptor ... However, it has been shown to have comparable affinity with calcitriol for the vitamin D receptor (VDR), while being less than ... Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of vitamin D. It is used in the ... calcipotriol application is thought to be mediated through the coactivation of vitamin D receptor/RXRα and vitamin D receptor/ ...
... binds vitamin D in blood Vitamin D receptor (VDR), or calcitriol receptor, the intracellular receptor for vitamin D Vitamin D ... an indicator of vitamin D status in the blood Calcitriol (1,25-dihydroxyvitamin D or 1,25(OH)2D), the active hormonal form of ... vitamin D Calcitroic acid (1,24,25-trihydroxyvitamin D), the major metabolite of calcitriol Vitamin D and respiratory tract ...
Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) (calcitriol) involves occupancy of vitamin D response ... elements (VDREs) by HNRNPC or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR). This relationship is disrupted by elevated HNRNPC ...
Calcitriol receptor, FHL2, GATA1, GATA2, HDAC1, HDAC4, HDAC5, HDAC6, Heparin-binding EGF-like growth factor, Nuclear receptor ... Zinc finger and BTB domain-containing protein 16 has been shown to interact with: Angiotensin II receptor type 1, BCL6, BMI1, ... Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998). "Reduced retinoic acid-sensitivities of nuclear receptor ... 2003). "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy". EMBO J. 22 (24): 6471- ...
This sequence binds the vitamin D receptor (VDR), when complexed with calcitriol (1,25(OH)2D), the activate form of vitamin D, ... 2D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR ... "Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor". Mol. Endocrinol. ... and vitamin D3 receptors". Cell. 65 (7): 1255-66. doi:10.1016/0092-8674(91)90020-Y. PMC 6159884. PMID 1648450. De Groot LJ, ...
... calcitonin gene-related peptide receptor - calcitonin receptor - calcitriol receptor - calcium channel - calcium signaling - ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ... IgE receptor - IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - ...
Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH)2D3 binding to the vitamin D receptor. The gene has a ... Theodoropoulos C, Demers C, Delvin E, Ménard D, Gascon-Barré M (April 2003). "Calcitriol regulates the expression of the genes ... It is a mitochondrial monooxygenase which catalyzes reactions including 24-hydroxylation of calcitriol (1,25-dihydroxyvitamin ... 25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts ...
Calcitriol (vitamin D) significantly inhibits the expression of the COX-2 gene. Caution should be exercised in combining low ... Litalien C, Beaulieu P (2011). "Chapter 117 - Molecular Mechanisms of Drug Actions: From Receptors to Effectors". In Fuhrman BP ...
Calcitriol, the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR), has, like the androgens, been ... "Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and ... "Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis ... As such, calcitriol, via the VDR, may be a negative regulator of ductal development but a positive regulator of lobuloalveolar ...
Calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D3, after being synthesized from calcifediol in the ... At millimolar concentrations, GSH and GSSG may also modulate the redox state of the NMDA receptor complex. Glutathione binds ... About ten days are needed for the body to process vitamin D3 into calcitriol. S-adenosylmethionine (SAMe), a cosubstrate ... GSH activates the purinergic P2X7 receptor from Müller glia, inducing acute calcium transient signals and GABA release from ...
The cannabinoid receptor type 1 (CB1), located at the presynaptic neuron, is a receptor that can stop stressful ... It stimulates the manufacture and release, by the kidneys, of calcitriol into the blood. This steroid hormone acts on the ... At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or ... When the receptor senses a stimulus, it reacts by sending action potentials to a control center. The control center sets the ...
These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the enzyme CYP24A1, also called ... studies determined that calcitroic acid binds to vitamin D receptor (VDR) and induces gene transcription. In vivo, studies ... Hydroxylation and further metabolism of calcitriol in the liver and the kidneys yields calcitroic acid, a water soluble ... calcitriol). Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after vitamin D is first ...
These integrin receptors are present on a number of immune cells such as mast cells, neutrophils, and T cells. It is also ... Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3). Regulation of the osteopontin gene is ... Upon binding these receptors, cells use several signal transduction pathways to elicit immune responses in these cells. OPN-R ... These receptors have been well-established to function in cell adhesion, migration, and survival in these cells. Osteopontin ( ...
Calcitriol, the activated form of vitamin D, promotes intestinal absorption of calcium and the renal reabsorption of phosphate ... It is accomplished via selective receptors on the luminal cell membrane. Water is 55% reabsorbed in the proximal tubule. ... For example, they convert a precursor of vitamin D to its active form, calcitriol; and synthesize the hormones erythropoietin ... The kidneys secrete a variety of hormones, including erythropoietin, calcitriol, and renin. Erythropoietin is released in ...
... and increases in the activation of vitamin D3 to calcitriol. Calcitriol, the active form of vitamin D3, promotes absorption of ... Ca2+ ion can also determine the speed of adaptation in a neural system depending on the receptors and proteins that have varied ... "Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor ...
... as well as inhibition of over-expression of Calcitriol receptor gene, resulting in inadequate bio-adaptation. He advocated ...
Atkins KB, Troen BR (July 1995). "Regulation of cathepsin D gene expression in HL-60 cells by retinoic acid and calcitriol". ... the agonist of formyl peptide receptor 3". Journal of Immunology. 187 (3): 1475-85. doi:10.4049/jimmunol.1003545. PMID 21709160 ...
Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, Pyykkö I, Tuohimaa P (July 2009). "Premature aging in vitamin D receptor ... The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification. Moreover, the ... Intake of vitamin D raises calcitriol concentrations in the plasma and cell Intake of vitamin D raises plasma calcifediol ... Intake of vitamin D raises the concentration of vitamin D metabolites which exceed DBP binding capacity and free calcitriol ...
They also express functional IL-7 receptors, consisting of subunits IL-7 receptor-α, CD127, and common-γ chain, CD132. In the ... Hence the activation of naive T cells is crucially dependent on adequate calcitriol levels. In summary, activation of T cells ... When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are ... Naive T cells are commonly characterized by the surface expression of L-selectin (CD62L) and C-C Chemokine receptor type 7 ( ...
5-trisphosphate receptor to regulate intracellular Ca2+ signaling; Oct-1 to form the coactivator complex OCA-S, which is ... and is induced by calcitriol". Biochemical and Biophysical Research Communications. 451 (1): 137-41. doi:10.1016/j.bbrc.2014.07 ... "The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor". The Journal of ... "Characterization of glyceraldehyde-3-phosphate dehydrogenase as a novel transferrin receptor". The International Journal of ...
Calcitriol receptor, Cyclin-dependent kinase 8, Estrogen receptor alpha, Glucocorticoid receptor, Hepatocyte nuclear factor 4 ... "Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205". Mol. Endocrinol ... Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (July 1998). "The TRAP220 component of a thyroid hormone receptor- associated ... Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (1998). "The TRAP220 component of a thyroid hormone receptor- associated protein ( ...
Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors. ... that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the ... participation of D receptor interacting proteins (called DRIP). ... Calcitriol Receptors: Proteins, usually found in the cytoplasm ... Calcitriol Receptor; Vitamin D Receptor; Receptor, Vitamin D; Receptors, Calcitriol; 1,25-Dihydroxycholecalciferol Receptor; 1, ...
Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol ... Keywords: PhyloCSF; VDR; calcitriol; nuclear receptor; readthrough; stop codon; transcription factor; transfer RNA (tRNA); ... VDRx displayed a reduced transcriptional response to calcitriol even in the presence of its partner retinoid X receptor. ... The readthrough efficiency of the annotated stop codon for the sequence encoding vitamin D receptor (VDR) was 6.7%. It was the ...
... of the calcitriol receptor.. 5. It is concluded that the intestinal calcitriol receptor of this animal model functions normally ... Studies of the Porcine Intestinal Calcitriol Receptor in Pseudo-Vitamin D Deficiency Rickets Type I B. Schröder ; B. Schröder ... B. Schröder, R. Kaune, J. Harmeyer; Studies of the Porcine Intestinal Calcitriol Receptor in Pseudo-Vitamin D Deficiency ... to altered binding properties of the intestinal calcitriol receptor in addition to the defective renal production of calcitriol ...
Receptors, Calcitriol Transcription Factor RelA alpha Karyopherins Substances Cytokines Immunologic Factors KPNA4 protein, ... by HBSMCs upon calcitriol treatment. Calcitriol attenuated the effect of TNF-α and IL-1β to upregulate mRNA and protein ... Calcitriol Cells, Cultured Cytokines Humans Immunologic Factors Myocytes, Smooth Muscle RNA, Messenger RNA, Small Interfering ... Calcitriol significantly decreased mRNA and protein expression of importin α3 as well as nuclear protein expression of NF-кB ...
When calcitriol binds to the receptor, the ligand-receptor complex translocates to the cell nucleus, where it acts as a ... Many of the effects of calcitriol are mediated by its interaction with the calcitriol receptor, also called the vitamin D ... For instance, the unbound inactive form of the calcitriol receptor in intestinal epithelial cells resides in the cytoplasm. ... Thus calcitriol also stimulates the intestinal absorption of phosphate. The observation that calcitriol stimulates the release ...
... and vitamin D3 receptor (VDR) were assessed after incubation with calcitriol for 2 weeks. Vitamin C as positive control (Vit. C ... for the 10−10 M calcitriol group, and for the 10−9 M calcitriol group, and for the 10−8 M calcitriol group, and and for the 10− ... 7 M calcitriol groups increased by (. ), (. ), and (. ) times, respectively, in the second week and (. ), (. ), and (. ) times ... 9 M calcitriol group (control with 10−9 M calcitriol), 10−8 M calcitriol group (control with 10−8 M calcitriol), and 10−7 M ...
We present two cases demonstrating effective treatment with excimer laser in conjunction with clobetasol spray and calcitriol ... and Calcitriol Ointment: A Case Series : Psoriasis is a chronic inflammatory skin disease that is characterized by thickened ... Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonis..... ABSTRACT:Cortexolone 17α-propionate ( ... Treatment of Psoriasis and Long-term Maintenance Using 308 nm Excimer Laser, Clobetasol Spray, and Calcitriol Ointment: A Case ...
... and lack of receptors or receptor affinity for D hormone in target organs. Reviewed here are six randomized controlled trials ... Further, calcitriol in combination with other therapeutic bone agents was shown to be well tolerated and capable of additional ... 1,25-(OH)2D3 (calcitriol) is an active vitamin D metabolite. It plays a role in many biological processes, especially in bone ... Calcitriol can also decrease bone turnover markers and bring about significant improvements in muscle strength. ...
1995) Influence of Vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain. BMJ ... With calcitriol, at doses of 0.8 and 0.62 μg daily respectively, lumbar spine BMD increased by 0.18%13 and 1.94%14 at two years ... 1989) Calcitriol treatment is not effective in postmenopausal osteoporosis. Ann Intern Med 110:267-274, . ... 1988) Calcitriol in the treatment of postmenopausal osteoporosis. Am J Med 84:401-408, . ...
C-met and vitamin D receptor (VDR) mRNA in cells were determined by using RT-PCR method. VDR and ERK(1/2) proteins were ... Calcitriol dissolved in LUF resulted in a better and longer inhibitive effect on the cell lines than Calcitriol alone. MHCC97 ... MHCC97 cell lines were treated with Calcitriol of 10(-6) approximately 10(-9) M concentration and with Calcitriol in lipiodol ... Calcitriol inhibits the growth of MHCC97 heptocellular cell lines by down-modulating c-met and ERK expressions.. Wu FS1, Zheng ...
VDR or Calcitriol Receptor) Agonist - Pipeline Insight, 2020 is a market research report available at US $1500 for a Single ... Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist Overview. 2.2. Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist ... Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist Structure. 2.4. Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist ... Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist Key Companies. 14. Vitamin D Receptor (VDR or Calcitriol Receptor) ...
The two known sites of action of calcitriol are intestine and bone. A calcitriol receptor-binding protein appears to exist in ... Use of calcitriol in patients with known hypersensitivity to calcitriol (or drugs of the same class) or any of the inactive ... Calcitriol from ingested calcitriol may be excreted in human milk. Because many drugs are excreted in human milk and because of ... If calcitriol therapy was previously administered at a dosage of 0.25 mcg/day, calcitriol therapy may be reinstituted at a ...
The two known sites of action of calcitriol are intestine and bone. A calcitriol receptor-binding protein appears to exist in ... CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH) CALCITRIOL. 1 ug in 1 mL. ... ROCALTROL- calcitriol capsule, gelatin coated. ROCALTROL- calcitriol solution. To receive this label RSS feed. Copy the URL ... Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an ...
Patients with known contraindication to selective Vitamin D receptor activators (VDRAs) according to the Summary of Product ... To evaluate the effect of PTH lowering on erythropoietin consumption in calcitriol-resistant patients with stage 5 chronic ... Patients treated only with intravenous calcitriol for at least 6 months. *Patients with serum intact parathyroid hormone (iPTH ... Calcitriol. Kidney Diseases. Renal Insufficiency, Chronic. Hyperparathyroidism. Hyperparathyroidism, Secondary. Urologic ...
Carrillo-López N, Fernández-Martín JL, Cannata-Andía JB (2009-04-01). "[The role of calcium, calcitriol and their receptors in ... There are two types of PTH receptors. Parathyroid hormone 1 receptors, activated by the 34 N-terminal amino acids of PTH, are ... Free OPG competitively binds to RANKL as a decoy receptor, preventing RANKL from interacting with RANK, a receptor for RANKL. ... Parathyroid hormone 2 receptors are present at high levels on the cells of central nervous system, pancreas, testes, and ...
Calcitriol receptor* Subclade* User:GAThrawn22/Sandbox2/wikiproject* Bare lymphocyte syndrome 2* Outcrossing* Human artificial ...
anti-cancer benefits of calcitriol (the active form of vitamin D), natural products is an effective way of blocking the ... "Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity." Endocrine 26 ... The chemosensitization of calcitriol actions at clinically relevant concentrations by aPPD is a highly promising approach for ... Calcitriol and 20(S)-protopanaxadiol synergistically inhibit growth and induce apoptosis in human prostate cancer cells: Beyond ...
Lee, TW, Lee, TI, Lin, YK, Kao, YH & Chen, YJ 2018, Calcitriol downregulates fibroblast growth factor receptor 1 through ... Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. / ... Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. ... Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. In ...
Receptors, Calcitriol / deficiency * Receptors, Calcitriol / genetics * Receptors, Calcitriol / physiology* * Serpins / ... Vitamin D receptor knock-out mice (VDR(-/-)) and wild-type mice (VDR(+/+)) were infected with 10(3) inclusion forming units of ... Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice J Steroid Biochem ...
Calcitriol Modulates Cardiac Fibroblasts through Noncanonical Pathway of Receptor for Advanced Glycation End Products and ... Fibroblast Growth Factor Receptor Signaling: Implicated in Cardiac Fibrosis in Diabetes. *李, 亭衛 (PI) ...
These data suggest that the calcitriol-induced ERα is a fully-transcriptionally active receptor. Interestingly, calcitriol per ... Estrogen receptorBreast cancerHormonal therapyCalcitriolVDR. Background. Breast cancer is a heterogeneous disease, encompassing ... An alternative, mechanism by which calcitriol via its receptor induced ERα expression might be at the level of promoter-driven ... Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic ...
Calcitriol-mediated FGFR1 downregulation was attenuated in the presence of SAHA. Calcitriol diminished FGFR1 expression through ... FGF-2 induced lower expressions of p-ERK and β-MHC in calcitriol-treated HL-1 cells than in control cells. FGFR1-knockdown ... In contrast, expressions of FGFR2, FGFR3, and FGFR4 were similar between calcitriol-treated and control HL-1 cells. FGF-2- ... In this study, we attempted to investigate whether calcitriol regulates FGFR1 expression to modulate the effects of FGF-2 ...
Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor ... These actions of calcitriol are mediated at least in part by vitamin D receptor (VDR), which is expressed in many tissues ... Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor ... Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and ...
Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast ... The combination of calcitriol and an AI may have potential benefits for BCa therapy. In addition to augmenting the ability of ... We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective ... In BCa cells, calcitriol also reduced the levels of prostaglandins (PGs), major stimulators of aromatase transcription, by ...
calcitriol receptor activity. ENSRNOP00000011601. GO:0043565. molecular_function. sequence-specific DNA binding. ... Nuclear hormone receptor, ligand-binding. ENSRNOP00000011601. Gene3D. G3DSA: IPR013088. 22. 108. 5.30e-28. Zinc ... Nuclear hormone receptor, ligand-binding, core. ENSRNOP00000011601. Pfam. PF00105. IPR001628. 23. 91. 1.80e-28. Zinc finger, ... Nuclear hormone receptor, ligand-binding. ENSRNOP00000011601. Gene3D. G3DSA:1.10.565.10. IPR008946. 209. 421. 6.60e-69. ...
calcitriol receptor activity. ENSMICP00000008211. GO:0043565. molecular_function. sequence-specific DNA binding. ... Nuclear hormone receptor, ligand-binding. ENSMICP00000008211. Gene3D. G3DSA: IPR013088. 20. 94. 8.50e-26. Zinc ... Nuclear hormone receptor, ligand-binding, core. ENSMICP00000008211. Pfam. PF00105. IPR001628. 23. 91. 9.90e-28. Zinc finger, ... Steroid hormone receptor. ENSMICP00000008211. ProSitePatterns. PS00031. IPR001628. 24. 50. -. Zinc finger, nuclear hormone ...
Lipophilic and able to go straight through plasma, bind to receptor in cytoplasm, binds to DNA in nucleus, attracts RNA ... Many ligands bind to receptors associated with membrane bound __ ___ to initiate transduction pathways. They react with other ... Cortisol, estradiol, progesterone, testosterone, aldosterone, calcitriol, and thyroid hormones stimulated by Cytoplasmic or ...
Paricalcitol is a synthetic form of calcitriol. It works by binding to two specific receptors on the parathyroid glands, known ... as vitamin D receptors and calcium sensing receptors. By binding to these two receptors paricalcitol reduces the production and ... The kidneys normally convert vitamin D into an active form called calcitriol, and this helps control the absorption of calcium ... However, in chronic kidney failure the kidneys are less effective at converting vitamin D into calcitriol. As a result, less ...
Binding of 1α,25-dihydroxyvitamin D3 to its receptor (VDR) causes gut absorption of calcium and phosphate, decrease in PTH ... Calcitriol category listing has 46. items along with related searches Items in both Kidney and Calcitriol categories in ... Calcitriol (active Vitamin D) recommended after kidney transplant - March 2014. Therapeutic use of calcitriol.. Curr Vasc ... Calcitriol (0.5 µg calcitriol twice per week) has been effective in decreasing proteinuria in patients with IgA nephropathy. In ...
makes calcitriol (1,25 (OH)2 Vit D) 20 calcitriol receptors type? fxn? ...
  • Hypercalcemia and hypercalciuria, the most common side effects of calcitriol therapy, were not documented in the trials reviewed, and might have been the result of the low dosages used. (
  • Many of the effects of calcitriol are mediated by its interaction with the calcitriol receptor, also called the vitamin D receptor or VDR. (
  • FGFR1-knockdown blocked FGF-2 signaling and reversed the protective effects of calcitriol. (
  • This study will explore the potential anti-proteinuric and anti-inflammatory effects of Calcitriol in the treatment of IgA nephropathy, which has no specific treatment at present. (
  • The VDR is a member of the nuclear receptor superfamily of ligand-inducible transcription factors, and it binds its major ligand, calcitriol, via its C-terminal ligand-binding domain. (
  • It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. (
  • When calcitriol binds to the receptor, the ligand-receptor complex translocates to the cell nucleus, where it acts as a transcription factor promoting the expression of a gene encoding a calcium binding protein. (
  • Free OPG competitively binds to RANKL as a decoy receptor, preventing RANKL from interacting with RANK, a receptor for RANKL. (
  • 12 Activated vitamin D binds to the vitamin D receptor to influence a diverse genetic response. (
  • Once converted, calcitriol attaches (binds) to a protein called vitamin D receptor (VDR), which is produced from the VDR gene. (
  • The resulting calcitriol-VDR complex then binds to particular regions of DNA and regulates the activity of vitamin D-responsive genes. (
  • 1,25(OH) 2 D functions as a ligand for the nuclear vitamin D receptor (VDR) which, when paired with its heterodimeric retinoid X receptor partner, binds to sequence-specific recognition elements on DNA and stimulates or represses transcription of contiguous genes. (
  • Following its synthesis in the kidney, calcitriol binds to DBP to be transported to target organs. (
  • Calcitriol, the active form of vitamin D (1,25 hydroxyvitamin D 3 ), binds to and activates the vitamin D receptor in kidney, parathyroid gland, intestine, and bone, stimulating intestinal calcium transport and absorption. (
  • MIS is up-regulated by calcitriol via a functional VDRE that binds the VDR. (
  • Calcitriol binds to a protein in cells called the vitamin D receptor, which then enters the cell's nucleus to control the expression of a variety of genes, including those involved in calcium absorption and bone health. (
  • When 1,25(OH) 2 D 3 , also known as calcitriol, binds to VDR protein, VDR is stabilized and translocates to nuclei. (
  • The beneficial effect of calcitriol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. (
  • Using XTT colorimetric assay we evaluated the effect of calcitriol on SiHa cells proliferation. (
  • We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD. (
  • Glucocorticoids potentiate the anti-tumor effect of calcitriol and decrease calcitriol-induced hypercalcemia. (
  • Research on the noncalcemic actions of calcitriol and other VDR-ligand analogs and their possible therapeutic applications has been reviewed. (
  • These actions of calcitriol are mediated at least in part by vitamin D receptor (VDR), which is expressed in many tissues including endothelial cells. (
  • The biological actions of calcitriol, involve regulation of gene expression at the transcriptional level, and are mediated through binding to a vitamin D receptor (VDR), located primarily in the nuclei of target cells (Jones et al. (
  • Up-regulation of MIS by calcitriol may be an important component of the antiproliferative actions of calcitriol in some cancers. (
  • We have studied whether or not the development of rachitic lesions in piglets with PVDRI is due to altered binding properties of the intestinal calcitriol receptor in addition to the defective renal production of calcitriol. (
  • Calcitriol is prescribed for: Treatment of hypocalcaemia - hypoparathyroidism, osteomalacia (adults), rickets (infants, children), renal osteodystrophy, chronic kidney disease Treatment of osteoporosis Prevention of corticosteroid-induced osteoporosis Calcitriol has been used in an ointment for the treatment of psoriasis, although the vitamin D analogue calcipotriol (calcipotriene) is more commonly used. (
  • The kidneys of uremic patients cannot adequately synthesize calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. (
  • Calcitriol treatment is not associated with an accelerated rate of renal function deterioration. (
  • Renal production of calcitriol is stimulated by PTH, low calcium and low phosphate and it is reduced by high phosphate and FGF23. (
  • In CKD stage, 3-4 moderate doses of calcitriol are effective to control secondary hyperparathyroidism and observational studies suggest that calcitriol therapy increases survival and slows the progression of renal disease as long as phosphate and calcium levels are controlled. (
  • The second reaction takes place in the kidney, mediated by 1α-hydroxylase (CYP27B1), which converts 25OHD to the biologically active hormone, calcitriol (1,25-dihydroxyvitamin D). The 1α-hydroxylase gene is also expressed in several extra-renal tissues, but its contribution to calcitriol formation in these tissues is unknown. (
  • The renal synthesis of calcitriol is tightly regulated by two counter-acting hormones, with up-regulation via parathyroid hormone (PTH) and down-regulation via fibroblast-like growth factor-23 (FGF23) (Galitzer et al. (
  • therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. (
  • Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing hypercalcemia. (
  • In dialysis patients, the administration of calcitriol reduces serum PTH levels but it is also known that high doses of calcitriol are associated with hypercalcemia and worse control of hyperphosphatemia. (
  • Incident calcitriol users and nonusers were selected on the basis of stages 3 to 4 CKD, hyperparathyroidism, and the absence of hypercalcemia before calcitriol use and then were matched by age and estimated kidney function. (
  • Calcitriol use was associated with a greater risk for hypercalcemia. (
  • Effective treatment with oral calcitriol is often impossible in patients with osteitis fibrosa, because low doses may cause hypercalcemia. (
  • Because short-term infusions of intravenous calcitriol are capable of suppressing the secretion of parathyroid hormone in patients with uremia without causing hypercalcemia, we evaluated the effectiveness of long-term intermittent calcitriol infusions (1.0 to 2.5 micrograms three times weekly, during dialysis) in treating severe osteitis fibrosa in 12 consecutive patients on hemodialysis whose disease was refractory to conventional therapy. (
  • A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. (
  • Effects of fibroblast growth factor (FGF) receptor 1 (FGFR1) knockdown on phosphorylated extracellular signal-regulated kinase (p-ERK) protein, and β-myosin heavy chain (β-MHC) mRNA expressions in HL-1 cells. (
  • The VDR protein is also involved in hair growth through a process that does not require calcitriol binding. (
  • We postulate that the chaperone protein Pdia3, an alternative plasma membrane-associated receptor for 1,25D3, may be responsible for the VDR-independent, anti-inflammatory effects on IgE-mediated mast cell activation. (
  • Calcitriol induces PARP cleavage, increases the bax/bcl-2 ratio, reduces levels of phosphorylated mitogen-activated protein kinases (P-MAPKs, P-Erk-1/2) and phosphorylated Akt (P-Akt), induces caspase-dependent MEK cleavage and up-regulation of MEKK-1, all potential markers of the apoptotic pathway. (
  • In combination with calcitriol, dexamethasone results in a significant time- and dose-dependent increase in VDR protein and an enhanced apoptotic response as compared to calcitriol alone. (
  • Hypoparathyroidism may result from genetic disorders that impair parathyroid gland development, synthesis of PTH, PTH receptor (PTHR1) function, or the G-protein (Gsa) that transduces the signal of PTHR1 (pseudohypoparathyroidism). (
  • This induces pro-phagocytic signaling mediated by the binding of the pro-phagocytic signaling protein calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. (
  • PTH also stimulates the production of calcitriol (see below). (
  • It is a component of the plasma membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D. As a ligand for estrogen-related receptor alpha (ESRRA), cholesterol becomes a signaling molecule. (
  • Evans RM: The steroid and thyroid hormone receptor superfamily. (
  • Weigel NL: Steroid hormone receptors and their regulation by phosphorylation. (
  • Kuiper GGJM, Brinkmann AO: Steroid hormone receptor phosphorylation: Is there a physiological role? (
  • The scientific community has now extensively accepted that calcitriol, commonly called "Vitamin" D, is a steroid (more precisely, a secosteroid) hormone. (
  • 1.5 were randomly allocated to an E group (each cycle = oral etidronate 400 mg daily for 14 days followed by calcium 500 mg daily for 76 days) or an E+C group (as for E plus oral calcitriol 0.5 μg daily). (
  • We evaluated associations of oral calcitriol use with mortality and dialysis dependence in 1418 nondialysis patients with CKD and hyperparathyroidism in the Veterans' Affairs Consumer Health Information and Performance Sets database. (
  • In conclusion, oral calcitriol use is associated with lower mortality in nondialysis patients with CKD. (
  • 2 , 7 , 8 In clinical trials of predialysis patients with CKD, oral calcitriol or its analogues lowered serum PTH levels. (
  • 18 - 21 Given biologic plausibility for an effect of oral calcitriol on survival and lack of clinical outcome data pertaining to this commonly prescribed CKD medication, we evaluated associations of oral calcitriol use with mortality and dialysis dependence in 1418 patients with stages 3 to 4 CKD and hyperparathyroidism. (
  • VDRx may form homodimers and heterodimers with VDR but, compared with VDR, VDRx displayed a reduced transcriptional response to calcitriol even in the presence of its partner retinoid X receptor. (
  • In gel shift assays, VDR and retinoid X receptor bound to the MIS VDRE and the binding was increased by calcitriol. (
  • Chromatin immunoprecipitation assays showed that VDR and retinoid X receptor were present on the MIS promoter in prostate cancer cells. (
  • The mRNA expressions of alkaline phosphatase (ALP), bone sialoprotein (BSP), core-binding factor alpha-1 (CBFA1), collagen-1 (Col-1), osteocalcin (OCN), and vitamin D 3 receptor (VDR) were assessed after incubation with calcitriol for 2 weeks. (
  • It plays a role in many biological processes, especially in bone metabolism and muscle function, and is mediated by vitamin D receptors. (
  • Osteoporosis in elderly men and women is characterized by uncoupled bone remodeling, which is induced by sex hormone deficiencies, somatopause, vitamin D deficiency, reduced synthesis of D hormone, and lack of receptors or receptor affinity for D hormone in target organs. (
  • Evidence from these trials shows that calcitriol monotherapy can improve bone mineral density in elderly osteoporotic Chinese patients but may be insufficient for long-term treatment. (
  • Calcitriol can also decrease bone turnover markers and bring about significant improvements in muscle strength. (
  • Further, calcitriol in combination with other therapeutic bone agents was shown to be well tolerated and capable of additional bone-preserving effects compared with use of calcitriol alone in areas including bone mineral density, bone turnover markers, bone pain improvement, and fracture incidence. (
  • The aim of this study was to compare the effects of intermittent cyclical etidronate (E) therapy alone with a combination of cyclical etidronate and calcitriol (E+C) on spine and femoral neck bone mineral density (BMD) at one year. (
  • The two known sites of action of calcitriol are intestine and bone. (
  • Parathyroid hormone 1 receptors, activated by the 34 N-terminal amino acids of PTH, are present at high levels on the cells of bone and kidney. (
  • The kidneys normally convert vitamin D into an active form called calcitriol, and this helps control the absorption of calcium from the gut and its turnover in bone. (
  • Calcitriol significantly decreased aromatase expression in human BCa cells and adipocytes and caused substantial increases in human osteosarcoma cells (a bone cell model exhibiting osteoblast phenotype in culture) and modest increases in ovarian cancer cells. (
  • In addition to augmenting the ability of AIs to inhibit BCa growth, calcitriol acting as a selective aromatase modulator that increases aromatase expression in bone would reduce the estrogen deprivation in bone caused by the AIs, thus ameliorating the AI-induced side effect of osteoporosis. (
  • At the bone level calcitriol suppresses pre-osteoblasts and activates mature osteoblasts. (
  • In kidney transplant patients, the administration of calcitriol, 0.5 µg/48h prevents bone mass loss during the first few months after transplantation. (
  • In addition to its well defined role as a key regulator of calcium and bone metabolism, 1,25-dihydroxyvitamin D (3) ( calcitriol ) has been established as a potent modulator of immune cell function. (
  • both calcitriol and paricalcitol stimulated osteoblast surfaces and rates of bone formation. (
  • Oversuppression of PTH secretion related to the administration of calcitriol alone or combined therapy with calcium-based phosphate binders can produce a different form of bone disease, known as adynamic bone disease, so careful monitoring is essential (Michael & Garcia, 2004). (
  • Calcitriol or 1,25-dihydroxycholecalciferol (vitamin D) is classically known for its effects on bone and mineral metabolism. (
  • In this study, we attempted to investigate whether calcitriol regulates FGFR1 expression to modulate the effects of FGF-2 signaling in cardiac myocytes and explored the potential regulatory mechanism. (
  • We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner. (
  • Since PTH regulates the activation of calcitriol via 1α-hydroxylase (Friedman et al. (
  • Transient receptor potential ion channel TRPM7 regulates exocrine pancreatic epithelial proliferation by Mg 2+ -sensitive Socs3a signaling in development and cancer. (
  • Vitamin D receptor (VDR) regulates most of the biological actions of the active vitamin D metabolite, 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ). (
  • Fcγ receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus. (
  • ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (
  • 5 , 6 A decline in calcitriol levels and a rise in serum PTH levels are among the first detectable mineral metabolism disturbances in CKD. (
  • Actual use of the active form of vitamin D (calcitriol or 1α,25-dihydroxyvitamin D(3)) to treat hyperproliferative disorders is hampered by calcemic effects, hence the continuous development of chemically modified analogues with dissociated profiles. (
  • Here, we report the crystallographic study of vitamin D nuclear receptor (VDR) ligand binding domain in complexes with six nonsecosteroidal analogues harboring two or three phenyl rings. (
  • Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). (
  • In someone with hypercalcaemia and high calcitriol levels, low intact parathyroid hormone levels are usually present. (
  • Calcitriol acts in concert with parathyroid hormone (PTH) in all three of these roles. (
  • Parathyroid hormone 2 receptors are present at high levels on the cells of central nervous system, pancreas, testes, and placenta. (
  • By binding to these two receptors paricalcitol reduces the production and release of parathyroid hormone from the parathyroid glands. (
  • [2] Instead it can be considered a hormone , with activation of the vitamin D pro-hormone resulting in the active form, calcitriol , which then produces effects via a nuclear receptor in multiple locations. (
  • The association of calcitriol with improved survival was not statistically different across baseline parathyroid hormone levels. (
  • 1 - 4 The kidneys play an important role in converting 25-hydroxyvitamin D to calcitriol, the most biologically potent vitamin D metabolite, under regulation by parathyroid hormone (PTH) and phosphate. (
  • In the past decade, a number of tissues have been found to contain receptors for the active vitamin D metabolite, 1,25(OH)2 D, and to respond to this hormone with a change in function. (
  • Calcitriol, a calcitrophic hormone that can be suppressed by high dietary calcium, favors fatty acid synthesis and inhibits lipolysis via non-genomic modulation of Ca 2 + influx. (
  • 2016 ), such as vitamin D (calcitriol) and parathyroid hormone (PTH). (
  • Xenobiotic exposures may induce alternative splicing in the pre-mRNA of nuclear hormone receptor (NHR) genes, yielding unpredictable patterns of gene expression that may promote adverse drug events and promote environmental disease. (
  • class I NHR), whereby alternatively-spliced AR transcripts induce ligand-independent hormone signaling via interactions with the wild-type (WT) AR, we designed an analogous system for probing similar phenomenon in the vitamin D receptor (VDR). (
  • The active vitamin D hormone, calcitriol, helps regulate both the innate and adaptive immune systems , our first and second lines of defence against pathogens. (
  • Calcitriol is the active form of vitamin D, normally made in the kidney. (
  • Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United States in 1978. (
  • Calcitriol is the most active known form of vitamin D 3 in stimulating intestinal calcium transport. (
  • Calcitriol (1,25-dihydroxycholecalciferol), the major active form of vitamin D, is antiproliferative in tumor cells and tumor-derived endothelial cells (TDEC). (
  • Due to the hypercalcemic side effects of vitamin D and its derivatives in higher plasma concentrations, the anti-cancer benefits of calcitriol (the active form of vitamin D) have not been fully realized in prostate cancer (PCa) chemoprevention and/or treatment. (
  • The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH) D ). In THP-1 human monocytes we obtained a highly accurate VDR cistrome after 2 and 24h ligand stimulation comprising >11,600 genomic loci, 78% of which were detected exclusively after 24h. (
  • There is also some evidence that calcitriol (1,25-dihydroxyvitamin D 3 ), a vitamin D analogue, may reduce vertebral fracture rates, 4 and a combination of vitamin D 3 and calcium supplements can reduce the risk of hip fractures and increase hip BMD in elderly women. (
  • Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines. (
  • mycobacterium avium, leprosy, lipoid pneumonia, cat scratch fever, berylliosis Calcitriol increases blood calcium levels ([Ca2+ ]) by: Promoting absorption of dietary calcium from the gastrointestinal tract. (
  • Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. (
  • In acutely uremic rats calcitriol has been shown to stimulate intestinal calcium absorption. (
  • It works by binding to two specific receptors on the parathyroid glands, known as vitamin D receptors and calcium sensing receptors. (
  • Binding of 1α,25-dihydroxyvitamin D3 to its receptor (VDR) causes gut absorption of calcium and phosphate, decrease in PTH synthesis, stimulation of FGF23. (
  • By turning these genes on or off, the calcitriol-VDR complex helps control the absorption of calcium and phosphate and other processes that regulate calcium levels in the body. (
  • Whereas the primary function of 1,25(OH)2D3 is to regulate calcium absorption and maintain mineral homeostasis, upon binding to its cognate vitamin D receptor (VDR), 1,25(OH)2D3 also decreases the proliferation and enhances the differentiation of colorectal cancer cells ( 5 ) as well as alters the transcription of a large number of genes involved in inhibiting carcinogenesis ( 6 , 7 ). (
  • 5. It is concluded that the intestinal calcitriol receptor of this animal model functions normally and that changes in binding properties and concentration of the intestinal calcitriol receptor do not contribute to the development of rachitic lesions in PVDRI piglets. (
  • For instance, the unbound inactive form of the calcitriol receptor in intestinal epithelial cells resides in the cytoplasm. (
  • Calcitriol decreases expression of importin α3 and attenuates RelA translocation in human bronchial smooth muscle cells. (
  • This study characterized alveolar periosteum-derived mesenchymal stem cells (P-MSCs) and examined the hypothesis that 1,25-(OH) 2 D 3 (calcitriol) exerts osteoinductive effects on P-MSCs. (
  • C-met and vitamin D receptor (VDR) mRNA in cells were determined by using RT-PCR method. (
  • Calcitriol inhibited the proliferation of MHCC97 cell lines with an accumulation of cells in the G(0)/G(1) phase and reduction of cells in S phase. (
  • Results: We found that calcitriol-treated HL-1 cells had significantly reduced FGFR1 expression compared to control cells. (
  • In contrast, expressions of FGFR2, FGFR3, and FGFR4 were similar between calcitriol-treated and control HL-1 cells. (
  • FGF-2 induced lower expressions of p-ERK and β-MHC in calcitriol-treated HL-1 cells than in control cells. (
  • Compared to control cells, calcitriol-treated HL-1 cells had higher nuclear HDAC activity. (
  • Vitamin D receptor knock-out mice (VDR(-/-)) and wild-type mice (VDR(+/+)) were infected with 10(3) inclusion forming units of Chlamydia muridarum and cervical epithelial cells (HeLa cells) were infected with C. muridarum at multiplicity of infection 5:1 in the presence and absence of 1,25-dihydroxyvitamin D3. (
  • The aim of the present study was to determine if calcitriol induces ERα expression in ER-negative breast cancer cells, thus restoring antiestrogen responses. (
  • Cultured cells derived from ERα-negative breast tumors and an ERα-negative breast cancer cell line (SUM-229PE) were treated with calcitriol and ERα expression was assessed by real time PCR and western blots. (
  • Gene expression of cyclin D1 ( CCND1 ), and Ether-à-go-go 1 ( EAG1 ) was also evaluated in cells treated with calcitriol alone or in combination with estradiol or ICI-182,780. (
  • Calcitriol was able to induce the expression of a functional ERα in ER-negative breast cancer cells. (
  • In addition, calcitriol-treated cells in the presence of ICI-182,780 resulted in a significant reduction of two important cell proliferation regulators CCND1 and EAG1 . (
  • Calcitriol induced the expression of ERα and restored the response to antiestrogens in ERα-negative breast cancer cells. (
  • FGF-2 (25 ng/mL for 30 min) did not increase ERK phosphorylation in FGFR1-knockdown cells without and with calcitriol (10 nM) treatment (right panel). (
  • We demonstrate that ocular co-expression of KCNC3R423H with Drosophila epidermal growth factor receptor (dEgfr) results in striking rescue of the eye phenotype, whereas KCNC3R423H expression in mammalian cells results in aberrant intracellular retention of human epidermal growth factor receptor (EGFR). (
  • In BCa cells, calcitriol also reduced the levels of prostaglandins (PGs), major stimulators of aromatase transcription, by suppressing the expression of cyclooxygenase-2 (which catalyzes PG synthesis) and increasing that of 15-hydroxyprostaglandin dehydrogenase (which catalyzes PG degradation). (
  • The mechanism of aromatase down-regulation by calcitriol in BCa cells is therefore 2-fold: a direct repression of aromatase transcription via promoter II through the vitamin D-response elements identified in this promoter and an indirect suppression by reducing the levels of PGs. (
  • However, studies in isolated cells suggest that vitamin D may only be able to activate its receptor with the direct cooperation of vitamin A, 1 , 2 and other studies have raised questions about vitamin A's ability to negate vitamin D's benefits if the ratio between them favors vitamin A too much. (
  • SiHa cells were cultivated with DMEM without phenol red and were treated with estradiol, tamoxifen, ICI 182 780, genistein or calcitriol during 48 hours. (
  • Concomitant treatment of SiHa cells with estradiol and calcitriol seems to potentiate such Eag1 down‐regulation. (
  • Our data suggest that down regulation of Eag1 by calcitriol could be a new mechanism by which calcitriol reduce tumor cells proliferation. (
  • Together, estradiol, antiestrogens, genistein and calcitriol could be used as treatment for cancers that present ER pattern expression silimar to SiHa cells. (
  • Calcitriol[ 1,25(OH) 2 D 3 ], the hormonal derivative of vitamin D 3 , is an antiproliferative and prodifferentiation factor for several cell types, including cultured melanocytes and malignant melanoma (MM) cells. (
  • Surprisingly, these effects do not require expression of the canonical receptor for 1,25D3 (VDR), as wild type and VDR KO mast cells are similarly suppressed by 1,25D3. (
  • Calcitriol (1,25-dihydroxyvitamin D(3)) inhibits the growth of a variety of cancer cells including human prostate cancer. (
  • In HeLa cells transfected with the vitamin D receptor (VDR), MIS promoter activity was stimulated by calcitriol. (
  • AU - Malloy,Peter J, AU - Peng,Lihong, AU - Wang,Jining, AU - Feldman,David, Y1 - 2008/12/04/ PY - 2008/12/6/pubmed PY - 2009/4/15/medline PY - 2008/12/6/entrez SP - 1580 EP - 7 JF - Endocrinology JO - Endocrinology VL - 150 IS - 4 N2 - Calcitriol (1,25-dihydroxyvitamin D(3)) inhibits the growth of a variety of cancer cells including human prostate cancer. (
  • Calcitriol is also a potent anti-proliferative agent in a wide variety of malignant cell types including prostate cancer cells. (
  • Electrophoretic mobility shift assays showed specific recruitment of vitamin D receptor to the VDRE in the HLA-DRB1 *15 promoter, confirmed by chromatin immunoprecipitation experiments using lymphoblastoid cells homozygous for HLA-DRB1 *15. (
  • Calcitriol alters the expression of many genes in brain cells. (
  • Calcitriol helps nerve cells turn into the specialized cells that are needed throughout the brain. (
  • A preparation of hematopoietic progenitor cells (HPCs) from a haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that can potentially be used for immune reconstitution purposes. (
  • Nearly all immune cells have vitamin D receptors , showing vitamin D interacts with the immune system. (
  • Calcitriol can also increase the number of a particular type of immune cell (CD8+ T cells), which play a critical role in clearing acute viral infections (such as influenza) in the lungs. (
  • Calcitriol also suppresses pro-inflammatory cytokines, molecules secreted from immune cells which, as their name suggests, promote inflammation. (
  • SARS-Cov-2 virus enters cells via ACE2 receptors. (
  • Some diuretics in cell cycle of individual which settled sponta- neously PASI, rifinah leukotriene receptor. (
  • Although there are dependent on a wide qRS :like leukotriene receptor antagonist bronchodilators. (
  • Methotrexate is sinus tachycardia of cytochrome p450 leukotriene receptor. (
  • 1 44 3857 leukotriene receptor antibodies to suppress ventricu- lar and calcitriol. (
  • Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. (
  • Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. (
  • In this work, we studied Eag1 regulation by estradiol, tamoxifen, ICI 182 780, genistein and calcitriol in the cervical cancer cell line SiHa, that express E6 an E7 HPV oncogenes. (
  • Different therapeutic candidates in early-stage, mid-stage and late stage of development for Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist. (
  • It comprises of detailed profiles of Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist therapeutic products with key coverage of involved technology, collaborations, licensing, mergers and acquisition, funding, designations and other product-related details. (
  • The combined treatment with calcitriol and antiestrogens could represent a new therapeutic strategy in ERα-negative breast cancer patients. (
  • Therapeutic use of calcitriol. (
  • Participants were randomly assigned to oral cholecalciferol (2000 IU daily) or calcitriol (0.5 μ g) daily for 6 months. (
  • Conclusions Six months of therapy with calcitriol or cholecalciferol did not improve vascular endothelial function or improve inflammation in patients with CKD. (
  • 2014), but also target key cell signaling pathways involving androgen receptor (AR) and steroidogenesis known to be dysregulated in PCa while enhancing vitamin D receptor (VDR) expression. (
  • Additional evidence suggests that calcitriol may also act on the kidney and the parathyroid glands. (
  • Data from a retrospective chart review consisting of children, adolescents, and adults (ages 2 to 33 years) with a diagnosis of pseudovitamin D deficiency rickets (PDDR) treated with calcitriol suggests that calcitriol may be effective for the treatment of this condition [Edouard 2011] . (
  • Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors. (
  • To evaluate the effect of PTH lowering on erythropoietin consumption in calcitriol- resistant patients with stage 5 chronic kidney disease. (
  • A third important effect of PTH on the kidney is its stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol), which is released into the circulation. (
  • However, in chronic kidney failure the kidneys are less effective at converting vitamin D into calcitriol. (
  • Vitamin D influences these levels after its dihydroxylation into calcitriol (at the 25 position in the liver and the 1 position in the kidney). (
  • Conversely, vitamin D deficiency can often occur from a combination of insufficient exposure to sunlight, inadequate dietary intake of vitamin D, genetic defects with endogenous vitamin D receptor, or even severe liver or kidney disease 1 . (
  • Tolvaptan (Jynarque), a selective vasopressin V2-receptor antagonist, was approved by the US.Food and Drug Administration (FDA) in April 2018 to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). (
  • Previous studies have demonstrated that Calcitriol or its analogs has an anti-tumour activity. (
  • The Potential Role of Calcitriol Analogs in the Management of Breast Cancer. (
  • 2009, 2012) and can potentially alter the prostate levels of calcitriol during the synergistic anti-cancer effects of this combination. (
  • individuals with VDDR1A and VDDR1B have abnormally low levels of calcitriol and individuals with VDDR2A and VDDR2B have abnormally high levels. (
  • One study showed that treatment with calcitriol can improve quality of life in patients with osteoporosis, although not to the same extent as bisphosphonates. (
  • Treatment with calcitriol resulted in growth inhibition in TDEC expressing VDR. (
  • Calcitriol induces a significant G 0 /G 1 arrest and modulates p21 Waf1/Cip1 and p27 Kip1 , the cyclin dependent kinase inhibitors. (
  • Treatment with 1,25(OH)2 vitamin D (calcitriol) induces elevated. (
  • Transient receptor potential (TRP) is a superfamily of channels that control the passage of cations across biological membranes (Yee et al. (
  • Progesterone and Vitamin D receptors belong to two different classes of this superfamily. (
  • A concentration of 10 −8 M calcitriol enhanced ALP, CBFA1, Col-1, and OCN mRNA expression at both weeks and BSP mRNA expression at the first week. (
  • Furthermore, 10 −7 M calcitriol increased the mRNA expressions of all compounds at both weeks, except that of CBFA1 at the first week. (
  • The results revealed that 10 −9 , 10 −8 , and 10 −7 M calcitriol induced osteoinduction in alveolar P-MSCs by increasing ALP, CBFA1, Col-1, and OCN mRNA expression. (
  • A 10 −7 M calcitriol yielded a higher mRNA expression than Vit. (
  • Calcitriol remarkably inhibited the expressions of c-met mRNA and ERK(1/2) proteins. (
  • Calcitriol administration to immunocompromised mice bearing human BCa xenografts decreased aromatase mRNA levels in the tumors and the surrounding mammary adipose tissue but did not alter ovarian aromatase expression. (
  • Estradiol, antiestrogens, genistein and calcitriol down‐regulated Eag1 mRNA expression. (
  • Paricalcitol is a synthetic form of calcitriol. (
  • 2. A sustained release pharmaceutical composition according to claim 1, wherein said Vitamin D or Vitamin D analog is selected from the group consisting paricalcitol, calcitriol and doxercalciferol. (
  • Compared with matched control subjects, calcitriol users had higher serum PTH levels, modestly lower eGFR, more nephrology clinic visits, and a slightly greater prevalence of comorbid conditions. (
  • Calcitriol also decreases interferon-gamma-induced HLA-DR antigen expression on normal and transformed human keratinocytes [ 11 , 12 ]. (
  • Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist - Pipeline Insight, 2020" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the mechanism of action. (
  • The assessment part of the report embraces, in-depth Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist commercial assessment and clinical assessment of the pipeline products under development. (
  • All the companies developing therapies of Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist with aggregate therapies developed by each company for the same. (
  • Key players involved in Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist targeted therapeutics development with respective active and inactive (dormant or discontinued) projects. (
  • Collaborations (company-company collaborations and company-academia collaborations), licensing agreements and financing details for future developments of Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist. (
  • Elucidated Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist research and development progress and trial details, results wherever available, are also included in the pipeline study. (
  • Coverage of dormant and discontinued pipeline projects along with the reasons if available across Vitamin D Receptor (VDR or Calcitriol Receptor) Agonist. (
  • Vitamin D receptor agonist supplementation and suppression of inflammation may have advantage for all-cause mortality in hemodialysis patients. (
  • CONCLUSION: Vitamin D deficiency in HD patients who had not taken vitamin D receptor agonist (VDRA) is associated with an increased risk of all-cause mortality. (
  • 1. Calcitriol (1,25-dihydroxyvitamin D 3 ) concentrations in plasma of humans and pigs with pseudo-vitamin D deficiency rickets type I (PVDRI) have been reported to be significantly lower than in normal subjects and animals. (
  • KDIGO guidelines do not recommend routine vitamin D therapy (with vitamin D supplements or a vitamin D analog [eg, calcitriol]) for progressive or persistently elevated PTH concentrations in CKD patients (stages 3-5) not on dialysis in the absence of suspected/documented Vitamin D deficiency. (
  • Interestingly, the calcitriol-induced ERα restored the response to antiestrogens by inhibiting cell proliferation. (
  • Calcitriol decreased cell proliferation after 5 days of culture. (
  • To investigate the role of VDR in calcitriol effects on tumor vasculature, we established TRAMP-2 tumors subcutaneously into either VDR wild-type (WT) or knockout (KO) mice. (
  • However, TDEC from KO mice were relatively resistant, suggesting that calcitriol-mediated growth inhibition on TDEC is VDR-dependent. (
  • In this study we found that the heart in vitamin D receptor knockout (VDR-KO) mice is hypertrophied. (
  • Which medications in the drug class Angiotensin II receptor antagonists are used in the treatment of IgA Nephropathy? (
  • Nonpeptide angiotensin II receptor antagonist that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. (
  • Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene ( PARP-1 ), neurotrophic factor (NTF), and Sp1 transcription factor. (
  • and optionally a therapeutically effective amount of at least one member of the group consisting of an angiotensin converting enzyme inhibitor, an angiotensin (II) receptor 1 blocker, and an aldosterone blocker. (
  • Transient receptor potential melastatin 7 cation channel kinase: new player in angiotensin II-induced hypertension. (
  • The drugs of choice for hypertension related to ADPKD are angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs). (
  • ARBs interfere with the binding of formed angiotensin II to its endogenous receptor. (
  • Valsartan is a prodrug that produces direct antagonism of angiotensin II receptors. (
  • It displaces angiotensin II from the AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water intake, and hypertrophic responses. (
  • Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking binding of angiotensin II to the AT-1 receptor in vascular smooth muscle. (
  • Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cyc. (
  • Sometimes, however, calcitriol concentrations are relatively high in these subjects and animals (50-80 pmol/l) and nevertheless clinical symptoms of rickets develop. (
  • PVDRI piglets with clinical and biochemical symptoms of rickets (hypocalcaemia, increased activity of alkaline phosphatase) and with calcitriol concentrations in plasma of 83.7 ± 4.2 pmol/l ( n = 7) were used. (
  • They were compared with unaffected piglets with normal calcitriol concentrations (178.0 ± 17.7 pmol/l, n = 9). (
  • Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1.0 mcg of calcitriol. (
  • Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol rose from a baseline value of 40.0±4.4 (SD) pg/mL to 60.0±4.4 pg/mL at 2 hours, and declined to 53.0±6.9 at 4 hours, 50±7.0 at 8 hours, 44±4.6 at 12 hours, and 41.5±5.1 at 24 hours. (
  • Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. (
  • This study was designed to determine the effect and mechanism of Calcitriol on MHCC-97 heptocellular cell lines. (
  • Conclusion- These results identify reduced vitamin D receptor signaling as a potential mechanism underlying increased foam cell formation and accelerated cardiovascular disease in diabetic subjects. (
  • Endogenous synthesis and catabolism of calcitriol, as well as physiological control mechanisms affecting these processes, play a critical role regulating the serum level of calcitriol. (
  • Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast cancer (BCa) in postmenopausal women. (
  • The synthesis of 1α,25-dihydroxyvitamin D3 (Calcitriol) takes place mostly in the kidneys through the action of 1α-hydroxylase (CYP27B1) which converts 25(OH)D into 1,25(OH)2D3. (
  • Low serum phosphorus levels stimulate calcitriol synthesis, whereas high serum phosphorus levels inhibit it. (
  • Furthermore, calcitriol modifies neuromuscular and immune functions [ 13 ]. (
  • Combining calcitriol with aPPD (S111) is logical for many reasons: low vitamin D levels are known to be a contributing cause of depression, immune disorders, endocrine-related cancers as well as increasing the risk of developing cancers of the colon, ovary, lung, breast and prostate. (
  • Calcitriol also has other effects, including some on cell growth, neuromuscular and immune functions, and reduction of inflammation. (
  • Both vitamins A and D contribute to immune function by binding to their respective receptors, thereby directing cellular processes that promote healthy immune responses. (
  • Systemic lupus erythematosus (SLE) is characterized by the presence of various autoantibodies and the deposition of immune complex, which is cleared by Fcγ receptors. (
  • Many of the ways calcitriol affects the immune system are directly relevant to our ability to defend against viruses. (
  • Calcitriol, the most biologically active form of Vit. (
  • Calcitriol inhibits the growth of MHCC97 heptocellular cell lines by down-modulating c-met and ERK expressions. (
  • 1,25-(OH) 2 D 3 (calcitriol) is an active vitamin D metabolite. (
  • Combinations of calcitriol with three different aromatase inhibitors (AIs) caused enhanced inhibition of BCa cell growth. (
  • We also identified estrogen receptors α and β and VDR (vitamin D receptor) proteins by Western blot. (
  • Furthermore, cholesterol-derived oxysterols activate liver X receptors (LXRs) or estrogen receptors (ERs). (
  • We have identified that a class of naturally derived ginsenoside molecules that not only inhibit the cytochrome P450-mediated catabolism and deactivation of calcitriol (Deb et al. (
  • These enzymes carry out the reactions that convert vitamin D to its active form, calcitriol. (
  • On the other hand, calcitriol (the most active metabolite of vitamin D) has shown antiproliferative properties and it has been considered as a potential anticancer treatment. (
  • Among the different forms of vitamin D, calcitriol (1,25-dihydroxyvitamin D 3 ) is best indicated for PD, because it is a highly active vitamin D 3 metabolite with an appropriate receptor in the central nervous system (CNS). (
  • The classical actions of vitamin D-which by itself is inactive-are due to the functions of the active metabolite, calcitriol. (
  • Once ingested or made by the body, vitamin D is converted through a series of steps into its active form, calcitriol. (
  • Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function. (
  • Several polymorphisms of the vitamin D receptor (VDR) gene have been described including a Fok I RFLP in exon 2, Bsm I, and Apa I polymorphisms in intron 8 and an adjacent Taq I RFLP in exon 9. (
  • Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. (
  • Hypocalcemia associated with low phosphate values suggests a disorder involving vitamin D. Mutations in the gene encodes 5-hydroxyvitamin D-1 alpha hydroxylase and in that encoding the vitamin D receptor also lead to hypocalcemia. (
  • FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). (
  • Furthermore, it has been shown that both ginsenosides and calcitriol can induce apoptosis and cause cell cycle arrest independently. (
  • These compounds induce a stimulated transcription in the nanomolar range, similar to calcitriol. (
  • Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. (